Gene Therapy Leaves a Vicious Cycle

Gene Therapy Leaves a Vicious Cycle Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States The human genetic code encrypted in thousands of genes holds the secret for synthesis of proteins that drive all biological processes necessary for normal life and death. Though the genetic ciphering remains unchanged through generations, some genes get disrupted, deleted and or mutated, manifesting diseases, and or disorders. Current treatment options—chemotherapy, protein therapy, radiotherapy, and surgery available for no more than 500 diseases—neither cure nor prevent genetic errors but often cause many side effects. However, gene therapy, colloquially called “living drug,” provides a one-time treatment option by rewriting or fixing errors in the natural genetic ciphering. Since gene therapy is predominantly a viral vector-based medicine, it has met with a fair bit of ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Authors: Rombauts A, Abelenda-Alonso G, Cuervo G, Gudiol C, Carratalà J Abstract INTRODUCTION: Despite adequate antibiotic coverage, community-acquired pneumonia (CAP) remains a leading cause of hospitalization and mortality worldwide. It induces both a local pulmonary and a systemic inflammatory response, particularly significant in severe cases. The intensity of the dysregulated host response varies from patient to patient and has a negative impact on survival and other outcomes. AREAS COVERED: This comprehensive review summarizes the pathophysiological aspects of the inflammatory response in CAP, brie...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part BAuthor(s): Yanhua Liu, Yang Li, Shanshan Dong, Lu Han, Ruixin Guo, Yourong Fu, Shenghu Zhang, Jianqiu Chen
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part AAuthor(s): Zhongyi Zhang, Wen-Xiong Wang, Nengjian Zheng, Yansheng Cao, Hongwei Xiao, Renguo Zhu, Hui Guan, Huayun Xiao
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Publication date: Available online 30 September 2020Source: Journal of Hazardous MaterialsAuthor(s): Anthony Beauvois, Delphine Vantelon, Jacques Jestin, Martine Bouhnik-Le Coz, Charlotte Catrouillet, Valérie Briois, Thomas Bizien, Mélanie Davranche
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
We describe the most highly recommended generic and disease-specific PRO tools in SCD and discuss the challenges of incorporating them in clinical practice. EXPERT OPINION: PRO measures are essential to incorporate into SCD clinical trials either as primary or secondary outcomes. The use of PRO measures in SCD facilitates a patient-centered approach, which is likely to lead to improved outcomes. Significant challenges remain in adapting PRO tools to routine clinical use and in developing countries. PMID: 33034214 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Musio F Abstract INTRODUCTION: Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multi-organ system processes. As a result of multiple randomized controlled trials (RCTs), meta-analyses, and societal recommendations overly restrictive paradigms and under-administration of erythropoiesis stimulating agents (ESAs) have likely been followed by clinicians among all specialties. AREAS COVERED: A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the e...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Publication date: Available online 9 October 2020Source: Mutation Research/Reviews in Mutation ResearchAuthor(s): Klaudia Kulczynska-Figurny, James J. Bieker, Miroslawa Siatecka
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research
Publication date: January 2021Source: Safety Science, Volume 133Author(s): Helen Lingard, Tracy Cooke, Greg Zelic, James Harley
Source: Safety Science - Category: Occupational Health Source Type: research
More News: Acute Leukemia | Acute Lymphoblastic Leukemia | Adenoidectomy | Adenoids | Adenoviruses | Allergy & Immunology | Anemia | Australia Health | Autoimmune Disease | Avastin | Back Pain | Biotechnology | Bird Flu | Blindness | Bone Marrow Transplant | Brain | Brain Cancers | Brain Tumor | Brazil Health | Bronchitis | Calcium | Canada Health | Cancer | Cancer & Oncology | Cancer Vaccines | Carcinoma | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Centers for Disease Control and Prevention (CDC) | Chemistry | Chemotherapy | Child Development | Children | Chile Health | China Health | Clinical Trials | Cold Sores | Colon Cancer | Colorectal Cancer | Common Cold | Conjunctivitis | Cystic Fibrosis | Cytomegalovirus | Databases & Libraries | Depression | Diabetes | Diabetes Type 1 | Ebola | Ebola Vaccine | Enbrel | Encephalitis | Endocrinology | Epithelial Cancer | European Medicines Agency (EMA) | Eye Cancers | Fish | Food and Drug Administration (FDA) | Funding | Gastroschisis Repair | Gene Therapy | Genetics | Genital Herpes | Glioma | Grants | Haemophilia | Head and Neck Cancer | Heart | Heart Transplant | Hematology | Hemophilia | Hepatocellular Carcinoma | Herceptin | Herpes | HNSCC | Hodgkin's Disease | Hormones | Humira | Immunotherapy | Infectious Diseases | Japan Health | Kidney Stones | Kidney Transplant | Kidney Transplantation | Leukemia | Leukodystrophies | Liver | Liver Cancer | Liver Transplant | Lucentis | Lymphoma | Marketing | MCATs | Measles | Measles Vaccine | Medical Ethics | Melanoma | Microbiology | Motor Neurone Disease | Muscular Dystrophy | Nanotechnology | Neurology | Neuroscience | Neurosurgery | Non-Hodgkin's Lymphoma | Opthalmology | Oral Cancer | Ovarian Cancer | Ovaries | Pain | Pain Management | Pancreas | Pancreatic Cancer | Parvovirus | Philippines Health | Physiology | Pneomococcal Vaccine | Pneumonia | Primary CNS Lymphoma | Prostate Cancer | Ranibizumab Injection | Rare Diseases | Reflex Sympathetic Dystrophy | Remicade | Research | Retinoblastoma | Rituxan | Russia Health | Sarcomas | Science | Skin Cancer | Sodium | Sore Throat | South Korea Health | Spinal Muscular Atrophy | Squamous Cell Carcinoma | Stem Cell Therapy | Stem Cells | Study | Suicide | Switzerland Health | Toxicology | Transplant Surgery | Transplants | University of Pennsylvania | Urology & Nephrology | USA Health | Vaccines | Varicella-Zoster Virus Vaccine | Veterinary Vaccinations | Vitamin A | von Willebrand Disease | Zinc