City of Hope's Triplex vaccine reduces rate of CMV complications in transplant recipients
(City of Hope) Patients who underwent a stem cell transplant and received the Triplex vaccine to prevent a type of herpes virus -- cytomegalovirus (CMV) -- from duplicating out of control were 50% less likely to develop health complications related to the virus than patients who did not take Triplex, according to a City of Hope-led study published today in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 10, 2020 Category: Infectious Diseases Source Type: news

Triplex reduces cytomegalovirus complications by half and induces immunity in stem cell transplant
(American College of Physicians) The novel Triplex vaccine reduced rates of cytomegalovirus (CMV) complications in patients undergoing allogeneic hematopoietic stem cell transplant (HCT) by half and induced immunity to the virus. No vaccine-associated safety concerns were identified. Findings from a phase 2 randomized clinical trial are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 10, 2020 Category: Infectious Diseases Source Type: news

Patient with unusually severe infection reveals a rare type of immune deficiency
(Rockefeller University) A rare genetic change may explain why some people die from cytomegalovirus, a stealth pathogen that is often asymptomatic. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 29, 2020 Category: Infectious Diseases Source Type: news

Cytomegalovirus seropositivity and suicidal behavior: a mini-review - Paolini M, Lester D, Hawkins M, Hawkins-Villarreal A, Erbuto D, Fiorillo A, Pompili M.
Background and objectives: In recent years, a growing body of research has focused on identifying possible biological markers for suicidal behavior, including infective and immunological markers. In this paper, our aim was to review available eviden... (Source: SafetyLit)
Source: SafetyLit - December 19, 2019 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Dangerous bone marrow, organ transplant complication explained
(Oregon Health& Science University) Scientists have discovered the molecular mechanism behind how the common cytomegalovirus can wreak havoc on bone marrow and organ transplant patients, according to a paper published in the journal Cell& Host Microbe. The finding could help researchers develop better drugs to prevent related transplant complications. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 19, 2019 Category: International Medicine & Public Health Source Type: news

Congenital viral infections in England over five decades: a population-based observational study
Study (data from 1968 to 2016) reports that compared with earlier years of the study, rates in 2016 were higher for congenital cytomegalovirus (CMV), herpes simplex virus, and varicella zoster virus, but lower for rubella. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 20, 2019 Category: Consumer Health News Source Type: news

Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
This alert, based on a European review, advises that if patients on nivolumab present with diarrhoea or colitis, investigate possible causes, including infections; perform a stool infection work-up and screen for CMV. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 25, 2019 Category: Consumer Health News Source Type: news

OHSU receives grant from Gates Foundation to develop universal flu vaccine
Oregon Health& Science University received a grant from the Gates Foundation to develop the Holy Grail of vaccines: a universal flu vaccine. OHSU is one of about six institutions that are splitting up to $12 million through the Grand Challenge for Universal Influenza Vaccine Development. The basis for OHSU’s effort will be its cytomegalovirus platform, which it is already using to develop vaccines against HIV and tuberculosis. The i nfluenza virus would be inserted into the CMV vector to stimulate… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 29, 2019 Category: Pharmaceuticals Authors: Elizabeth Hayes Source Type: news

OHSU receives grant from Gates Foundation to develop universal flu vaccine
Oregon Health& Science University received a grant from the Gates Foundation to develop the Holy Grail of vaccines: a universal flu vaccine. OHSU is one of about six institutions that are splitting up to $12 million through the Grand Challenge for Universal Influenza Vaccine Development. The basis for OHSU’s effort will be its cytomegalovirus platform, which it is already using to develop vaccines against HIV and tuberculosis. The i nfluenza virus would be inserted into the CMV vector to stimulate… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - August 29, 2019 Category: Biotechnology Authors: Elizabeth Hayes Source Type: news

HIV vaccine nears clinical trial following new findings
A promising vaccine that clears an HIV-like virus from monkeys is closer to human testing after a new, weakened version of the vaccine has been shown to provide similar protection as its original version. A pair of papers published July 17 in Science Translational Medicine describe how the vaccine - which uses a form of the common herpes virus cytomegalovirus, or CMV - was live-attenuated, or weakened so CMV couldn't spread as easily. (Source: World Pharma News)
Source: World Pharma News - July 24, 2019 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

HIV vaccine nears clinical trial following new findings
(Oregon Health& Science University) A promising vaccine that clears an HIV-like virus from monkeys is closer to human testing after a new, weakened version of the vaccine has been shown to provide similar protection as its original version. The vaccine -- which uses a form of the common herpes virus cytomegalovirus, or CMV -- was live-attenuated, or weakened so CMV couldn't spread as easily. Having an attenuated version of the vaccine is key to being potentially able to use it in humans. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 17, 2019 Category: Infectious Diseases Source Type: news

Simple Blood Draw Detects Dangerous Pathogens
Liquid biopsy has attracted a surge of companies that are trying to change the way cancer is detected and monitored. But the benefits of this new type of technology can - and should - seep into other disease categories. Redwood City, CA-based Karius, for example, is leveraging liquid biopsy technology to give doctors an upper hand on difficult-to-diagnose infectious diseases. New findings show the potential clinical utility of its the Karius Test to detect pathogens causing serious infections using a simple blood draw. This includes pathogens that are otherwise difficult to culture or identify witho...
Source: MDDI - June 26, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: IVD Source Type: news

What Infectious Diseases are Important to Consider in Transplantation Patients?
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - June 24, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Cytomegalovirus Linked to Faster Progression of Cystic Fibrosis
Faster progression to end - stage lung disease observed among patients with CMV IgG positivity (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - April 11, 2019 Category: Respiratory Medicine Tags: Infections, Pulmonology, Journal, Source Type: news

Cytomegalovirus Linked to Faster Progression of Cystic Fibrosis
THURSDAY, April 11, 2019 -- For patients with cystic fibrosis (CF), cytomegalovirus (CMV) is associated with faster disease progression, according to a research letter published online April 7 in the European Respiratory Journal. Michael D. Parkins,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 11, 2019 Category: Pharmaceuticals Source Type: news

New research unit approved
(University of W ü rzburg) A new international research group aims to develop new approaches to prevent and treat cytomegalovirus infection. Lars D ö lken, a virology expert from W ü rzburg, is the research unit's spokesman. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 10, 2019 Category: Infectious Diseases Source Type: news

Common virus is 'less prone to mutation' giving hope for vaccine development
(University College London) One of the commonest causes of congenital disability, the Human Cytomegalovirus (HCMV), is less prone to mutation than previously thought, a finding which could help develop a successful vaccine, UCL researchers have found. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - February 25, 2019 Category: Infectious Diseases Source Type: news

What Is the Most Common Type of Cardiomyopathy?
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - February 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Outfitting T cell receptors to combat a widespread and sometimes deadly virus
(American Society for Biochemistry and Molecular Biology) Researchers have engineered 'antibody-like' T cell receptors that can specifically stick to cells infected with cytomegalovirus, or CMV, a virus that causes lifelong infection in more than half of all adults by age 40. These receptors represent a new potential treatment option, could aid the development of CMV vaccines and might also be used to target brain tumors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 22, 2019 Category: International Medicine & Public Health Source Type: news

New vaccine offers fresh take on malaria fight
(Oregon Health& Science University) Early research on a new approach to protecting against malaria is offering promising, potentially long-lasting results against the persistent parasite that sickens hundreds of millions people each year. The approach uses a cytomegalovirus-based platform that's already being used in vaccines being developed to battle HIV and tuberculosis. This new vaccine reduced the malaria-causing parasite's release from the liver and into the blood of infected rhesus macaques by 75 to 80 percent, reports a paper published in the journal PLOS ONE. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - January 23, 2019 Category: Biology Source Type: news

Effect of cytomegalovirus reactivation on the time course of systemic host response biomarkers in previously immunocompetent critically ill patients with sepsis: a matched cohort study
The authors of this journal article state thatcytomegalovirus (CMV) reactivation in previously immunocompetent critically ill patients is associated with increased mortality, which has been hypothesized to result from virus-induced immunomodulation. They studied the effects of CMV reactivation on the temporal course of host response biomarkers in patients with sepsis. CMV reactivation was not independently associated with changes in the temporal trends of host response biomarkers in comparison with non-reactivating patients. They therefore conclude that these markers should not be used as surrogate clinical endpoints for i...
Source: Current Awareness Service for Health (CASH) - January 17, 2019 Category: Consumer Health News Source Type: news

Scientists learn how common virus reactivates after transplantation
(Fred Hutchinson Cancer Research Center) A new study in Science challenges long-held theories of why a common virus -- cytomegalovirus, or CMV -- can reactivate and become a life-threatening infection in people with a compromised immune system, including blood cancer patients undergoing bone marrow transplantation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 17, 2019 Category: Cancer & Oncology Source Type: news

Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation
Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical mouse models of cytomegalovirus reactivation after transplantation and found that humoral immunity is essential for preventing viral recrudescence. Preexisting antiviral antibodies decreased after transplant in the presence of graft-versus-host disease and were not replaced, owing to poor reconstitution of donor B cells and elimination of recipient plasma cells. Viral reactivation was prevented by the transfer of immune serum, without a need to identify and target s...
Source: ScienceNOW - January 17, 2019 Category: Science Authors: Martins, J. P., Andoniou, C. E., Fleming, P., Kuns, R. D., Schuster, I. S., Voigt, V., Daly, S., Varelias, A., Tey, S.-K., Degli-Esposti, M. A., Hill, G. R. Tags: Immunology, Medicine, Diseases reports Source Type: news

What are Some of the Causes of SGA?
Discussion Intrauterine growth retardation or fetal growth retardation is due to a pathological process that causes decelerated fetal growth velocity. Small-for-gestational age (SGA) is an infant with growth parameters below the normal range for gestational age. More commonly, SGA is defined as a birth weight
Source: PediatricEducation.org - December 10, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

FDA OKs First Diagnostic Aid for Congenital Cytomegalovirus FDA OKs First Diagnostic Aid for Congenital Cytomegalovirus
The Alethia CMV Assay Test System detects the DNA of CMV in the saliva of newborns and should only be used in conjunction with the results of other diagnostic tests and clinical information.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 3, 2018 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Alert Source Type: news

FDA authorizes first test to aid in detecting a type of herpes virus in newborns called cytomegalovirus
(Source: Food and Drug Administration)
Source: Food and Drug Administration - November 30, 2018 Category: American Health Source Type: news

Infant HIV Infection Ups Risk for Congenital CMV Infection
THURSDAY, Oct. 25, 2018 -- HIV-exposed infants have high rates of congenital cytomegalovirus (cCMV) infection, and in utero HIV infection seems to be a major risk factor for cCMV, according to a study published in the October issue of The Pediatric... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 25, 2018 Category: Pharmaceuticals Source Type: news

HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection
FINDINGSInfants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection.The researchers found that 23 percent of the infants who became infected with HIV during the mother ’s pregnancy also were infected with CMV; 18 percent who were infected with HIV either during pregnancy or birth acquired congenital CMV; and 4.9 percent who were exposed to HIV but remained uninfected with that virus also acquired congenital CMV.Overall, HIV-infected infants were four times as likely to have a...
Source: UCLA Newsroom: Health Sciences - October 15, 2018 Category: Universities & Medical Training Source Type: news

HIV-positive infants are at high risk for acquiring congenital cytomegalovirus infection
(University of California - Los Angeles Health Sciences) Infants born to HIV-positive mothers had high rates of congenital cytomegalovirus, or CMV. Infants who also were infected before birth by the virus that causes AIDS were especially prone to CMV infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 15, 2018 Category: Infectious Diseases Source Type: news

Pregnant mothers warned not to eat a child ’s leftovers
Scientists at St George's University of London have cautioned pregnant mothers that cytomegalovirus can be transmitted through children's saliva and infect unborn babies. (Source: the Mail online | Health)
Source: the Mail online | Health - September 11, 2018 Category: Consumer Health News Source Type: news

Scientists find a new way to attack herpesviruses
(Gladstone Institutes) A team of scientists led by Leor S. Weinberger, PhD, the William and Ute Bowes Distinguished Professor and director of the Gladstone-UCSF Center for Cell Circuitry, uncovered the mechanism that allows cytomegalovirus to replicate. Their study, published in the scientific journal PNAS, could open new therapeutic avenues to treat several herpesviruses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 28, 2018 Category: International Medicine & Public Health Source Type: news

UC Davis researchers find quiet viruses alter body's response to vaccines, pathogens
(University of California - Davis Health System) UC Davis researchers have shown that low levels of cytomegalovirus (CMV) have a significant impact on microbe and immune cell populations and how the immune system responds to the influenza vaccine. The study was published in the Journal of Virology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 3, 2018 Category: International Medicine & Public Health Source Type: news

Diseases Passed from Mom to Newborn Can Threaten Baby
Doctors say the transfer of an infection from a pregnant mother to a newborn can pose a serious threat to the baby, including deafness and a malformed brain. Three congenital infections — syphilis, cytomegalovirus (CMV), and HIV — are especially problematic in Texas, reports the July issue of Texas Medicine magazine. (Source: TMA News Room)
Source: TMA News Room - July 16, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Scientists 'completely surprised' by immunity-boosting virus
Cytomegalovirus — a common, asymptomatic virus — may actually boost the immune system's response to infection, much to specialists' surprise. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 4, 2018 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

This virus actually may boost -- not weaken -- our immune system
(University of Arizona Health Sciences) Lifelong cytomegalovirus infection may be beneficial, boosting the immune system in old age, when we need it most, according to a new study in the Proceedings of the National Academy of Sciences. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 2, 2018 Category: International Medicine & Public Health Source Type: news

Dormant cytomegalovirus resides in eyes of healthy mice long after infection
(PLOS) Infection with cytomegalovirus triggers long-lasting eye inflammation and establishes a dormant pool of the virus in the eyes of mice with healthy immune systems, according to new research presented in PLOS Pathogens by Valentina Voigt of the Lions Eye Institute in Western Australia and colleagues. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 31, 2018 Category: Infectious Diseases Source Type: news

Cytomegalovirus Infection in an Immunocompetent Patient Cytomegalovirus Infection in an Immunocompetent Patient
CMV infection is normally symptomatic only in immunocompromised patients; however, this case demonstrates the potential for serious infection in otherwise healthy, immunocompetent patients.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 27, 2018 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

$8.9 million collaborative grant to understand how dangerous virus 'hides' to attack another day
(University of Arizona Health Sciences) Dr. Felicia Goodrum and several of the nation's most prominent human cytomegalovirus researchers have been awarded a five-year, $8.9 million collaborative grant to investigate how the virus lies dormant until it activates and poses life-threatening disease risk. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 23, 2018 Category: International Medicine & Public Health Source Type: news

Astellas and Vical Announce Top-Line Results for Phase 3 Trial of Cytomegalovirus Vaccine ASP0113 in Hematopoietic Stem Cell Transplant Recipients
TOKYO and SAN DIEGO, Jan. 22, 2018 -- (Healthcare Sales & Marketing Network) -- Astellas Pharma Inc. (TSE: 4503, President and CEO: Yoshihiko Hatanaka, "Astellas") and Vical Incorporated (NASDAQ: VICL) announced today that ASP0113, an investigat... Biopharmaceuticals Astellas Pharma, Vical , cytomegalovirus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - January 22, 2018 Category: Pharmaceuticals Source Type: news

No Adverse Neurologic Hit From Postnatal CMV Infection in Preemies No Adverse Neurologic Hit From Postnatal CMV Infection in Preemies
Premature babies of mothers with cytomegalovirus who pick up the infection from breast milk are unlikely to develop neurological problems in early childhood as a result, according to a Dutch study.Reuters Health Information (Source: Medscape Pediatrics Headlines)
Source: Medscape Pediatrics Headlines - January 16, 2018 Category: Pediatrics Tags: Pediatrics News Source Type: news

A common virus may help inform treatment planning for stem cell transplant patients
(Virginia Commonwealth University) a team of scientists from VCU Massey Cancer Center have shown a genetic relationship between the reactivation of the human cytomegalovirus and the onset of graft-versus-host disease (GVHD), a potentially deadly condition in which the immune system attacks healthy tissue following a bone marrow or stem cell transplant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 7, 2017 Category: Cancer & Oncology Source Type: news

Letermovir (Prevymis) Okayed for Stem Cell Transplant Infection Letermovir (Prevymis) Okayed for Stem Cell Transplant Infection
The drug prevents cytomegalovirus infections and disease in adults previously exposed to the common virus who have received an allogeneic hematopoietic stem cell transplant.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 9, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA Approves Prevymis (letermovir) for Prevention of Cytomegalovirus (CMV) Infection and Disease in Adult Allogeneic Stem Cell Transplant Patients
KENILWORTH, N.J.--(BUSINESS WIRE) November 9, 2017 --Merck& Co., Inc. (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Prevymis (letermovir) once-daily... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - November 9, 2017 Category: Drugs & Pharmacology Source Type: news

Study: therapists lack knowledge to prevent transmission of CMV
(Midwestern University) Results from a new health-risk knowledge survey indicate that physical and occupational therapists are at increased risk of contracting cytomegalovirus (CMV), a leading cause of prenatal infection and lifelong disabilities, but that they lack sufficient knowledge to prevent its transmission. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 4, 2017 Category: Infectious Diseases Source Type: news

Immune system cells protect against CMV-induced hearing loss in mice
(PLOS) Immune system cells known as natural killer cells play an important protective role against hearing loss in mice infected with cytomegalovirus (CMV), according to a new study published in PLOS Pathogens. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 28, 2017 Category: International Medicine & Public Health Source Type: news

What Causes Microcephaly?
Patient Presentation A 5-month-old male came to clinic for his health supervision visit and followup from his neonatal intensive care stay. He was born prematurely at 28 weeks gestation and his stay was complicated by a right sided Grade III intraventricular hemorrhage, a left-sided Grade IV intraventricular hemorrhage, neonatal seizures, respiratory distress and bronchopulmonary dysplasia, retinopathy of prematurity, acute kidney injury that had resolved, possible necrotizing enterocolitis incidents x 2, and herpes simplex encephalitis. He was on home oxygen, a nasogastric feeding tube because of aspiration risk and mult...
Source: PediatricEducation.org - September 25, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Treating a little-known virus, CMV, to combat hearing loss in children
(University of Utah Health) A National Institutes of Health-supported nationwide clinical trial will test a novel approach to combat hearing loss in children infected by a relatively unknown virus, cytomegalovirus (CMV). The University of Utah Health-led study will determine whether antiviral therapy can halt progressive hearing loss in children with a confirmed CMV infection. CMV is the leading non-genetic cause of hearing loss, contributing from 6 to 30 percent of childhood cases. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - September 14, 2017 Category: Infectious Diseases Source Type: news

Team led by UCLA, UCSF receives $8 million to study virus that often strikes after kidney transplants
UCLA, UC San Francisco and City of Hope have received a five-year, $8 million grant from the National Institute of Allergy and Infectious Diseases to study how a common virus called cytomegalovirus may provoke the immune system to reject transplanted kidneys.The 14-member interdisciplinary team is co-led by Elaine Reed, who holds the Daljit S. and Elaine Sarkaria Endowed Chair in Diagnostic Medicine at UCLA and is director of the UCLA Immunogenetics Center.  “Nearly 70 percent of people around the world carry antibodies to the cytomegalovirus infection, yet healthy people rarely display symptoms,” said Ree...
Source: UCLA Newsroom: Health Sciences - August 24, 2017 Category: Universities & Medical Training Source Type: news

NIAID herpesvirus study in mice leads to discovery of potential broad-spectrum antiviral
(NIH/National Institute of Allergy and Infectious Diseases) NIAID scientists studying herpes simplex virus infection have unexpectedly found that inhibiting a cellular enzyme complex, EZH2/1, suppresses viral infection. The researchers then demonstrated that EZH2/1 inhibitors also enhanced the cellular antiviral response in cultured cells and mice. They then showed that EZH2/1 inhibitors suppressed HSV infection, spread, and reactivation in mice and, in cell culture, suppressed human cytomegalovirus, adenovirus, and Zika virus infections. They suggest that EZH2/1 inhibitors have considerable potential as broad-spectrum ant...
Source: EurekAlert! - Medicine and Health - August 15, 2017 Category: International Medicine & Public Health Source Type: news

Issues with maternal screening for congenital cytomegalovirus infection
(Kobe University) Human cytomegalovirus (CMV) is a common virus found worldwide. When CMV infects fetuses, it can cause serious complications such as hearing difficulties and mental retardation in affected infants. A group of researchers have evaluated for the first time the efficacy of maternal universal screening using CMV IgG avidity tests for congenital CMV infection, and they have also identified issues with the current maternal CMV screening methods. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 24, 2017 Category: Infectious Diseases Source Type: news