Interleukin-6 May Reliably Identify Patients with High-Grade Serous Ovarian Cancer
A new tool, in combination with those already existing, could distinguish between patients with malignant and benign ovarian masses, as well as those with a benign ovarian mass and normal ovaries. (Source: CancerNetwork)
Source: CancerNetwork - February 21, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Woman recovering from cancer becomes first in the world to give birth after freezing immature eggs
Doctors took immature eggs from the French woman's ovaries before artificially maturing them in the lab and freezing them. Years later, the eggs were thawed and fertilised, and the woman had a baby. (Source: the Mail online | Health)
Source: the Mail online | Health - February 19, 2020 Category: Consumer Health News Source Type: news

Statins 'block an enzyme thought to trigger ovarian cancer' 
Women who naturally exhibit lower levels of an enzyme blocked by statins have an estimated 40 per cent lower risk of ovarian cancer, a study by Bristol University found. (Source: the Mail online | Health)
Source: the Mail online | Health - February 18, 2020 Category: Consumer Health News Source Type: news

Could statins lower the risk of ovarian cancer?
In the UK, ovarian cancer is the sixth most common cancer in females*. A new study has found evidence to suggest that statins could lower the risk of women developing ovarian cancer. The research led by the University of Bristol, and funded by Cancer Research UK, is published today [18 February] in JAMA. (Source: University of Bristol news)
Source: University of Bristol news - February 18, 2020 Category: Universities & Medical Training Tags: Health, Research, International; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Bristol Population Health Science Institute; Press Release Source Type: news

Mother could give birth to her own GRANDCHILD
Jasmine Bowley, 21, from Norwich, had her ovaries and Fallopian tubes removed when she developed pelvic Ewing's sarcoma aged seven - which also affected her womb. (Source: the Mail online | Health)
Source: the Mail online | Health - February 18, 2020 Category: Consumer Health News Source Type: news

Functional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective, targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC. Using multiplexed inhibitor beads and mass spectrometry, we mapped the kinome landscape of HGSOC tumors from patients and patient-derived xenograft models. The data revealed a prevalent signature consisting of established HGSOC driver kinases, as well as several kinases previously unexplored in HGSOC. Loss-of-function analysi...
Source: Signal Transduction Knowledge Environment - February 18, 2020 Category: Science Authors: Kurimchak, A. M., Herrera-Montavez, C., Brown, J., Johnson, K. J., Sodi, V., Srivastava, N., Kumar, V., Deihimi, S., OBrien, S., Peri, S., Mantia-Smaldone, G. M., Jain, A., Winters, R. M., Cai, K. Q., Chernoff, J., Connolly, D. C., Duncan, J. S. Tags: STKE Research Articles Source Type: news

Test measures immune response to improve ovarian cancer diagnosis
(RMIT University) About 300,000 new cases of ovarian cancer are diagnosed globally each year, with about 60% of women dying within five years after diagnosis. A clinical trial has shown testing for a specific immune biomarker could improve diagnosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

Susan Band Horwitz Wins Prestigious Cancer Research Award for Anti-Tumor Drug Discovery
February 14, 2020—(BRONX, NY)—Susan Band Horwtiz, Ph.D., distinguished professor of molecular pharmacology and the Rose C. Falkenstein Chair in Cancer Research at Albert Einstein College of Medicine, has been awarded the National Foundation for Cancer Research’s (NFCR) 2020 Szent-Györgyi Prize for Progress in Cancer Research. The honor recognizes her pioneering research establishing the mechanism of action of anti-tumor drugs, including Taxol, that are used to treat ovarian, breast, and lung cancers. (Source: Einstein News)
Source: Einstein News - February 14, 2020 Category: Universities & Medical Training Source Type: news

Nigeria: Premature Ovarian Insufficiency (I)
[This Day] We always imagine that women within their reproductive age should be able to get pregnant on their own. It is really devastating for young beautiful women to be told by their physician that they cannot achieve pregnancy naturally. (Source: AllAfrica News: Pregnancy and Childbirth)
Source: AllAfrica News: Pregnancy and Childbirth - February 14, 2020 Category: OBGYN Source Type: news

Autophagy genes act as tumor suppressors in ovarian cancer
(Medical University of South Carolina) Researchers at the Medical University of South Carolina and University of California at San Diego report in PLOS Genetics that the loss of BECN1 promoted early ovarian cancer formation and genomic instability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Ovarian cancer hope after discovery of six types of cell that trigger the 'silent killer' 
By detecting the abnormal cells in the fallopian tube lining, ovarian cancer could be diagnosed earlier. Currently just over a third of English patients live for five years after diagnosis of the 'silent killer'. (Source: the Mail online | Health)
Source: the Mail online | Health - February 10, 2020 Category: Consumer Health News Source Type: news

Scientists closer to finding the cell of origin for ovarian cancer
(University of Oxford) Researchers have used a new technique to identify six previously unknown cell types in human Fallopian tubes, paving the way for faster identification and treatment of ovarian cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

UCLA research could be step toward lab-grown eggs and sperm to treat infertility
A new study on how and when the precursors to eggs and sperm are formed during development could help pave the way for generating egg and sperm cells in the lab to treat infertility.The study, published in the journal Cell Reports, describes the way in which human stem cells evolve into germ cells, the precursors for egg and sperm cells.“Right now, if your body doesn’t make germ cells then there’s no option for having a child that’s biologically related to you,” said Amander Clark, the study’s lead author, a member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem...
Source: UCLA Newsroom: Health Sciences - February 6, 2020 Category: Universities & Medical Training Source Type: news

After Cancer Took His Mother, James Allison Taught Our Immune Systems How to Fight It
There once was a boy in Alice, Texas, who saw things a little differently from everybody else. Influenced by his father, a “country” doctor, he was drawn to science instead of football and conducted biology experiments in his parents’ garage. When he was 10, someone gave him a harmonica, but he never took a lesson or learned to read music, so he wandered the woods mimicking what he’d heard on the radio. A year after that, his mother died following a long struggle with lymphoma. What he still remembers decades later are her last, bedridden days when he spent hours holding her hand, and the burns sing...
Source: TIME: Health - February 6, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Research Source Type: news

Image of the Day: Old Ovaries
Oxidative stress associated with aging damages ovarian cells in both humans and nonhuman primates. (Source: The Scientist)
Source: The Scientist - February 6, 2020 Category: Science Tags: Image of the Day Source Type: news

FDA Moves Closer to Standardized Testing for Asbestos in Talc
The U.S. Food and Drug Administration moved closer on Tuesday to formulating standardized testing of talc-based products for the presence of toxic asbestos fibers. Experts from eight different federal agencies explained earlier recommendations at a day-long hearing. The session also featured input from 25 members of the public, which included industry representatives, consumer advocates and testing experts. “Standards are needed,” said Dr. Paul Howard, FDA Office of Regulatory Science, during his presentation. “They just don’t exist at this time.” Dr. Linda Katz, director of the FDA Office of ...
Source: Asbestos and Mesothelioma News - February 5, 2020 Category: Environmental Health Authors: Matt Mauney Source Type: news

Ovarian cancer symptoms: This sign when you go to the toilet may signal the deadly disease
OVARIAN cancer symptoms can be difficult to recognise in the early stages, but all like all cancers, recognising symptoms when they appear is important to ensure a better chance of survival. One way to spot ovarian cancer is to notice a certain change in your bowel habits. (Source: Daily Express - Health)
Source: Daily Express - Health - February 5, 2020 Category: Consumer Health News Source Type: news

There is hope for a new test to diagnose early-stage lung cancer | Letters
Pauline ArmoryandMaxine Arnott write about a recently completed trial that has the potential to detect lung cancer with a blood testandProf Martin Marshallsays it wrong to blame GPs for failing to spot symptomsYou rightly report that one of the key reasons lung cancer is the biggest cause of cancer deaths in the UK is that up to 56% of lung cancers are only discovered in A&E where patients present with late-stage symptoms, by which point they often have only months to live (Report, 31 January).Every year in the UK around 40,000 people are diagnosed with lung cancer and 35,000 people die – it kills more women, for...
Source: Guardian Unlimited Science - February 4, 2020 Category: Science Authors: Letters Tags: Lung cancer NHS Cancer research Health Society Medical research Science Source Type: news

Dianne Oxberry died 10 days after she was told she had cancer... now her husband shares her story
Dianne Oxberry died aged 51, just ten days after being diagnosed with an aggressive form of ovarian cancer. The pain and shock is still visible in the eyes of her grieving husband, Ian Hindle. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news

MRI Tool Identifies Risk of Malignancy in Adnexal Masses
The O-RADS MRI tool could potentially reduce unnecessary or over-extensive surgery in patients with various types of ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - February 4, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Manufacturing Effects on Material Properties
Conclusion Being a part of the 30% - 40% of companies with materials-related recalls can be a detriment to your business. Consider incorporating materials science into your development capabilities and reach out to experts to understand what manufacturing variation could cause material property changes. Assess materials in your risk analysis and especially test for potential variation factors having a direct or confounding effect on your product’s performance. Editor's Note: Stacie Depner will be moderating "Tech Talk Panel: Criteria for Choosing the Right Material for Your Device," ...
Source: MDDI - February 3, 2020 Category: Medical Devices Authors: Stacie Depner Tags: Materials Source Type: news

Janssen to Highlight Depth of Solid Tumor Portfolio at ASCO GU
RARITAN, N.J., February 3, 2020 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today multiple data presentations from a robust solid tumor portfolio that will be featured at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium, taking place February 13-15 in San Francisco. Company-sponsored data presentations will include clinical results for ERLEADA® (apalutamide) and niraparib in prostate cancer; and BALVERSA™ (erdafitinib) in bladder cancer. “We are committed to improving outcomes in patients with prostate and bladder cancer where high unmet...
Source: Johnson and Johnson - February 3, 2020 Category: Pharmaceuticals Tags: Innovation Source Type: news

MRI scoring system improves ovarian cancer detection
Researchers from France and the U.K. have developed an MRI-based, five-point...Read more on AuntMinnie.comRelated Reading: MRI faster, cheaper than ultrasound for appendicitis Optical imaging finds small tumors New imaging method could boost ovarian cancer detection Ultrasound helps predict ovarian cancer risk Cinematic rendering enhances ovarian cancer evaluation (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 3, 2020 Category: Radiology Source Type: news

Study: How to safely remove ovary in girls for best results in fertility preservation
(Ann& Robert H. Lurie Children's Hospital of Chicago) Using an experimental piglet model, researchers defined the safest laparoscopic technique for removing the ovary in young girls that also results in the best quality ovarian tissue for fertility preservation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 3, 2020 Category: International Medicine & Public Health Source Type: news

The menopause isn ’t so scary that young women need to sign up for costly surgery | Catherine Bennett
The benefits of tissue harvesting to delay a supposed middle age hell are doubtfulAgainst a background of tasteful pastel – which signals from the off that we are in the land of discretionary spending on faulty female anatomy – theProFaM website makes its unique bid for women ’s money. Ovarian tissue storage! And not only for fertility-related reasons. Who’d want a menopause? “Will you be ready?” the website challenges. “You never know what the future holds, so freeze the biological clock and prepare for the future.”For many women, alas, the offer will be empty. The ProFaM cl...
Source: Guardian Unlimited Science - February 2, 2020 Category: Science Authors: Catherine Bennett Tags: Menopause Health Medical research Society Fertility problems Women Life and style Science UK news Source Type: news

Russian woman, 30, has enormous cysts filled with HAIR removed from her ovaries
Dr Tatania Shavrak at the Kolomna Perinatal Centre, near Moscow, said some of the hairs were five inches in length, with the cysts - one in each ovary - weighing almost four ounces (113g). (Source: the Mail online | Health)
Source: the Mail online | Health - January 31, 2020 Category: Consumer Health News Source Type: news

PFS Not Established as a Surrogate End Point for OS in Treatment of Ovarian Cancer
This large meta-analysis was found to support the GCIG Fifth Ovarian Cancer Consensus statement that OS is the preferred primary end point. (Source: CancerNetwork)
Source: CancerNetwork - January 31, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

MRI tool can diagnose difficult cases of ovarian cancer
(Imperial College London) Researchers have developed a new MRI tool that can identify cases of ovarian cancer which are difficult to diagnose using standard methods. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 30, 2020 Category: International Medicine & Public Health Source Type: news

The first roadmap for ovarian aging
(Salk Institute) Infertility likely stems from age-related decline of the ovaries, but the molecular mechanisms that lead to this decline have been unclear. Now, scientists from the US and China have discovered, in unprecedented detail, how ovaries age in non-human primates. The findings reveal several genes that could be used as biomarkers and point to therapeutic targets for diagnosing and treating female infertility and age-associated ovarian diseases, such as ovarian cancer, in humans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 30, 2020 Category: International Medicine & Public Health Source Type: news

Obesity Medicine Association announces key updates to its 2020 Adult Obesity Algorithm
(Obesity Medicine Association) The Obesity Medicine Association (OMA) today announced the immediate availability of the 2020 OMA Obesity Algorithm ® , with new information for clinicians including obesity myths, polycystic ovary syndrome, obesity and psychiatric disease, ketogenic diet, as well as many other updates. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 30, 2020 Category: International Medicine & Public Health Source Type: news

Medicare to Cover Gene Tests in Inherited Breast, Ovarian Cancer Medicare to Cover Gene Tests in Inherited Breast, Ovarian Cancer
CMS has set national payment policy on advanced genetic tests for germline ovarian and breast cancers while providing flexibility for their use in other diseases.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 29, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Health-Related Quality of Life Lower for Women With PCOS
TUESDAY, Jan. 28, 2020 -- Women with polycystic ovary syndrome (PCOS) report low health-related quality of life (HRQoL) beyond the reproductive years, according to a study published online Jan. 23 in the Journal of Clinical Endocrinology&... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 28, 2020 Category: Pharmaceuticals Source Type: news

Novel molecules display potent and selective action against ovarian tumor cells
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Compounds based on palladium, a metal belonging to the same group as platinum, have been developed by researchers from Brazil, the UK and Italy. In vitro tests show action against tumor cells that are resistant to treatment currently used. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2020 Category: Cancer & Oncology Source Type: news

Study examines genetic testing in diverse young breast cancer patients over a decade
(Florida Atlantic University) Researchers examined racial and ethnic differences in genetic testing frequency and results among diverse breast cancer patients diagnosed at age 50 or younger from January 2007 to December 2017. They found that among 1,503 diverse young breast cancer patients, less than half (46.2 percent) completed hereditary breast and ovarian cancer genetic testing. However, the percentage of women who completed genetic testing increased over time from 15.3 percent in 2007 to a peak of 72.8 percent in 2015. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 28, 2020 Category: Cancer & Oncology Source Type: news

ONCOS-102 Shows Promise in Combination Mesothelioma Treatment
ONCOS-102, a promising immunotherapy vaccine, is moving closer to becoming a part of future first-line treatment for mesothelioma. Early clinical trial results announced this week show safety and efficacy when the vaccine is used in combination with standard-of-care chemotherapy for patients with inoperable pleural mesothelioma. Targovax, a Scandinavian pharmaceutical company developing the drug, is moving forward with another study combining ONCOS-102 with a checkpoint inhibitor drug such as Keytruda (pembrolizumab) or Opdivo (nivolumab), along with chemotherapy. “We have seen enough data at this point to be going ...
Source: Asbestos and Mesothelioma News - January 27, 2020 Category: Environmental Health Authors: Matt Mauney Source Type: news

Mother, 42, with polycystic ovary syndrome told she may not have children goes on to have TEN kids
Emma Gale, 42, from Whitstable, Kent, was diagnosed with polycistic ovary syndrome aged 18, before being told she may never be able to have children. (Source: the Mail online | Health)
Source: the Mail online | Health - January 24, 2020 Category: Consumer Health News Source Type: news

Microbiome may play role in PCOS
According to a study published in theJournal of Clinical Endocrinology& Metabolism, gut microbiomes with an unhealthy bacteria profile may be associated with polycystic ovary syndrome and obesity adolescents.Science Daily (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 24, 2020 Category: Endocrinology Source Type: news

Obese women with polycystic ovary syndrome have more harmful gut bacteria
Colorado researchers looked at the guts of 58 obese teenage girls with PCOS. They found these girls had high levels of bacteria linked to too much testosterone - a cause of PCOS. (Source: the Mail online | Health)
Source: the Mail online | Health - January 23, 2020 Category: Consumer Health News Source Type: news

Oral hormone-blocking drug may help with heavy menstrual bleeding
(Thomas Jefferson University) In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 23, 2020 Category: International Medicine & Public Health Source Type: news

Differential effects of the menstrual cycle on reactive and proactive aggression in borderline personality disorder - Peters JR, Owens SA, Schmalenberger KM, Eisenlohr-Moul TA.
Borderline personality disorder (BPD) is characterized by rapidly shifting symptoms, including intense anger and aggressive behavior. Understanding how fluctuations in ovarian hormones across the menstrual cycle may contribute to symptom instability is key... (Source: SafetyLit)
Source: SafetyLit - January 22, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

FDA Panel Recommends Standardized Talc Testing for Asbestos
A team of experts from eight different federal agencies has presented the U.S. Food and Drug Administration with preliminary recommendations to standardize the testing of talc for the presence of asbestos and other potentially harmful mineral products. The recommendations, some of which reject long-held talc industry positions, are designed to end the discrepancies in analysis of whether talc products are contaminated with cancer-causing substances. Preliminary recommendations will be part of the FDA’s public meeting on Feb. 4 to discuss and obtain scientific information on testing for asbestos in talc-based products...
Source: Asbestos and Mesothelioma News - January 21, 2020 Category: Environmental Health Authors: Matt Mauney Source Type: news

Activation of Apelin Signaling Decreases VEGF Inhibitor Efficacy in Ovarian Cancer Treatment
A recent study suggested the activation of apelin/APJ signaling decreased efficacy in VEGF treatment, while bevacizumab decreased disease-free survival rates with increased expression of apelin in patients of ovarian cancer. (Source: CancerNetwork)
Source: CancerNetwork - January 21, 2020 Category: Cancer & Oncology Authors: Matthew Fowler Source Type: news

Polycystic Ovary Syndrome Hikes Bipolar Disorder Risk Polycystic Ovary Syndrome Hikes Bipolar Disorder Risk
The risk of developing bipolar disorder was increased in women with PCOS, possibly because of shared inflammatory pathways, a study has found; metformin may have a protective effect.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - January 20, 2020 Category: Psychiatry Tags: Ob/Gyn & Women ' s Health News Source Type: news

Medical News Today: Adnexal mass: What to know
Adnexal masses are lumps that form in the adnexa of the uterus, which includes the uterus, ovaries, and fallopian tubes. Keep reading to learn more. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 18, 2020 Category: Consumer Health News Tags: Women's Health / Gynecology Source Type: news

New Data On Talcum Powder/Ovarian Cancer Connection
The issue of talc-based powder putting women at increased risk for ovarian cancer was also a focus of many of the suits, although direct evidence of talcum powder acting as a potential cause of ovarian cancer had not been determined. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - January 16, 2020 Category: Pharmaceuticals Authors: Nina Shapiro, Contributor Source Type: news

Risk of eating and sleeping disorders higher for women with PCOS
According to a study published inClinical Endocrinology, the likelihood of developing sleeping and eating disorders may be higher for women with polycystic ovary syndrome.Healio (Source: Society for Endocrinology)
Source: Society for Endocrinology - January 15, 2020 Category: Endocrinology Source Type: news

Lynparza regulatory submission granted Priority Review in the US for 1st-line maintenance treatment with bevacizumab in advanced ovarian cancer
AstraZeneca and MSD Inc., Kenilworth, N.J., US (MSD: known as Merck & Co., Inc. inside the US and Canada) announced that a supplemental New Drug Application for Lynparza (olaparib) in combination with bevacizumab has been accepted and granted Priority Review in the US for the maintenance treatment of patients with advanced ovarian cancer who are in complete or partial response to 1st-line platinum-based chemotherapy with bevacizumab. (Source: World Pharma News)
Source: World Pharma News - January 15, 2020 Category: Pharmaceuticals Tags: Featured AstraZeneca Business and Industry Source Type: news

Green light for cancer treatment for BRCA mutations
Approved for platinum-sensitive ovarian cancer Related items fromOnMedica Experts disappointed at NICE decision on ovarian cancer drug Put case for adding leukaemia drug to Cancer Drugs Fund, NICE tells company Debate goes on over valproate in pregnancy HPV programme linked to dramatic fall in cervical disease Quarter million people taking benzodiazepines for more than a year (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 15, 2020 Category: UK Health Source Type: news

FDA Grants Priority Review to Olaparib, Bevacizumab Combination for Ovarian Cancer
The priority review was based on results from the phase III PAOLA-1 trial comparing the addition of olaparib to bevacizumab vs the standard-of-care alone. (Source: CancerNetwork)
Source: CancerNetwork - January 13, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news

Protein associated with ovarian cancer exacerbates neurodegeneration in Alzheimer's
(Houston Methodist) Houston Methodist scientists identified a protein found in ovarian cancer that may contribute to declining brain function and Alzheimer's disease, by combining computational methods and lab research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 12, 2020 Category: Cancer & Oncology Source Type: news