High-Grade Serous Ovarian Cancer during Pregnancy: From Diagnosis to Treatment
CONCLUSIONS: There have not been long-term follow-ups of patients' oncologic and obstetric outcomes. As patients should be comprehensively informed, more detailed case reports or series with longer follow-up periods are needed.PMID:38668047 | DOI:10.3390/curroncol31040144 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Gregor Vivod Sebastjan Merlo Nina Kovacevic Source Type: research
Multivariate data analysis of process parameters affecting the growth and productivity of stable Chinese hamster ovary cell pools expressing SARS ‐CoV‐2 spike protein as vaccine antigen in early process development
In this study, we analyze early process development data of recombinant trimeric spike protein Cumate-inducible manufacturing platform utilizing CHO stable pool as a preferred production host across three different stirred-tank bioreactor scales (0.75, 1, and 10 L). The impact of cell passage number as an indicator of cell age, methionine sulfoximine (MSX) concentration as a selection pressure, and cell seeding density was investigated using stable pools expressing three variants of concern. Multivariate data analysis with principal component analysis an d batch-wise unfolding technique was applied to evaluate the effec...
Source: Biotechnology Progress - April 26, 2024 Category: Biotechnology Authors: Sebastian ‐Juan Reyes,
Lucas Lemire,
Raul‐Santiago Molina,
Marjolaine Roy,
Helene L'Ecuyer‐Coelho,
Yuliya Martynova,
Brian Cass,
Robert Voyer,
Yves Durocher,
Olivier Henry,
Phuong Lan Pham Tags: RESEARCH ARTICLE Source Type: research
Genes, Vol. 15, Pages 554: Exploring the Role of the MUTYH Gene in Breast, Ovarian and Endometrial Cancer
Conclusions: our results fail to demonstrate that germinal monoallelic MUTYH variants increase cancer risk through a LOH (loss of heterozygosity) mechanism in the somatic tissue; however, the absence or partial loss of the MUTYH protein in many tumors suggests its dysregulation regardless of MUTYH genetic status. (Source: Genes)
Source: Genes - April 26, 2024 Category: Genetics & Stem Cells Authors: Carla Lintas Benedetta Canalis Alessia Azzar à Giovanna Sabarese Giuseppe Perrone Fiorella Gurrieri Tags: Article Source Type: research
Intraoperative findings of duplicated Inferior Vena Cava during laparoscopic para-aortic lymphadenectomy
A 57-year-old patient with a diagnosis of ovarian clear cell carcinoma after bilateral adnexectomy underwent surgical staging at our gynecologic oncologic center. During laparoscopic para-aortic lymphadenectomy, we identified and exposed the double infrarenal vena cava (Edwards ’ Classification [1]), with the left inferior vena cava terminating in the left renal vein (Figure 1). No paracaval or interaortocaval lymph nodes were found on the left side. Surgery was performed without intraoperative or postoperative complications. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - April 26, 2024 Category: OBGYN Authors: Stefano Uccella, Andrea Caraffini, Pier Carlo Zorzato, Simone Garzon Tags: Images in Gynecologic Surgery Source Type: research
Cancers, Vol. 16, Pages 1682: BRCA1/2 Testing Landscape in Ovarian Cancer: A Nationwide, Real-World Data Study
da H. de Bock
Analyzing BRCA1/2 tumor pathogenic variants (TPVs) in epithelial tubal/ovarian cancers (EOCs) has become an essential part of the diagnostic workflow in many centers to guide treatment options and genetic cascade testing. However, there is no standardization of testing procedures, including techniques, gene assays, or sequencers used, and data on the execution of tumor tests remains scarce. Therefore, we evaluated characteristics of BRCA1/2 tumor testing in advanced-stage EOC with real-world national data. Pathology reports of patients diagnosed with EOC in 2019 in the Netherlands were obtained from the D...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Lieke Lanjouw Joost Bart Marian J. E. Mourits Stefan M. Willems Annemieke H. van der Hout Arja ter Elst Geertruida H. de Bock Tags: Article Source Type: research
Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats
This study aims to compare the oral and local treatments of metformin or its nanoparticles (NPs11) for ameliorating PCOS in rats. Rats were divided into 4 groups: the control group with no drug treatment; the PCOS group, where subcutaneous testosterone was given (10 mg/kg/day) for 28 days; the MET group, where metformin was administered orally or locally; and the NP group, where metformin NPs11 were also administered orally or locally. Oral administrations were for 21 days, while local injection was performed once surgically. After 7 weeks, all rats were sacrificed; blood glucose and serum hormonal levels and lipid profile...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Sadeq Al-Thamarani Shadeed Gad Islam Omar Abdel Fattah Sami H Hammadi Taha M Hammady Source Type: research
A rare case of mullerianosis of the liver and lung mimicking metastatic biliary cystadenocarcinoma
We report a mullerianosis involving the liver and lung in a 41-year-old female that mimicked metastatic biliary cystadenocarcinoma. It is the first case reported in literature where there is simultaneous involvement of the liver and lung by mullerianosis. The diagnosis was made with the help of histopathology and immunohistochemistry in the resected specimens.PMID:38660757 | DOI:10.1177/14782715241247244 (Source: Journal of the Royal College of Physicians of Edinburgh)
Source: Journal of the Royal College of Physicians of Edinburgh - April 25, 2024 Category: General Medicine Authors: Charles Panackel Joe Francis Mathew Nita John Mathew Jacob Source Type: research
Factors defining developmental competence of bovine oocytes collected for in vitro embryo production
Biol Reprod. 2024 Apr 25:ioae065. doi: 10.1093/biolre/ioae065. Online ahead of print.ABSTRACTDespite the currently relatively low effectiveness of producing bovine embryos in vitro, there is a growing interest in applying this laboratory method in the field of reproduction. Many aspects of the procedure need to be improved. One of the main problems is the inferior developmental competence of in vitro matured oocytes that are collected using the ovum pick-up (OPU) method. The mechanisms of oocyte capacitation and maturation, as well as the in vivo conditions in which they grow and mature, should be carefully analyzed. A del...
Source: Reproductive Biology - April 25, 2024 Category: Reproduction Medicine Authors: Aleksandra Teresa Pytel Krystyna Żyżyńska-Galeńska Zdzis ław Gajewski Krzysztof Papis Source Type: research
Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish †
Biol Reprod. 2024 Apr 24:ioae040. doi: 10.1093/biolre/ioae040. Online ahead of print.ABSTRACTIn oviparous animals, egg yolk is largely derived from vitellogenin, which is taken up from the maternal circulation by the growing oocytes via the vitellogenin receptor. Recently, a novel member of the lipoprotein receptor superfamily termed low-density lipoprotein receptor-related protein 13 was identified and proposed as a candidate of vitellogenin receptor in oviparous animals. However, the roles of low-density lipoprotein receptor-related protein 13 in vitellogenesis are still poorly defined. Here, we investigated the expressi...
Source: Reproductive Biology - April 25, 2024 Category: Reproduction Medicine Authors: Zhiquan Liu Nan Zhang Chuangxin Wang Lina Shi Yixuan Hu Yamei Wang Jianzhen Li Source Type: research
Evaluation of serum CA125, HE4 and CA724 and the risk of ovarian malignancy algorithm score in the diagnosis of high-grade serous ovarian cancer
CONCLUSION: The new algorithm using CA125 and BRCA1/2 helped to distinguish between patients with HGSOC and patients with non-HGSOC.PMID:38663180 | DOI:10.1016/j.ejogrb.2024.04.022 (Source: Reproductive Biology)
Source: Reproductive Biology - April 25, 2024 Category: Reproduction Medicine Authors: Deyu Hu Jun Qian Fenghua Yin Bing Wei Jiayu Wang Huijuan Zhang Haiou Yang Source Type: research
Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish †
Biol Reprod. 2024 Apr 24:ioae040. doi: 10.1093/biolre/ioae040. Online ahead of print.ABSTRACTIn oviparous animals, egg yolk is largely derived from vitellogenin, which is taken up from the maternal circulation by the growing oocytes via the vitellogenin receptor. Recently, a novel member of the lipoprotein receptor superfamily termed low-density lipoprotein receptor-related protein 13 was identified and proposed as a candidate of vitellogenin receptor in oviparous animals. However, the roles of low-density lipoprotein receptor-related protein 13 in vitellogenesis are still poorly defined. Here, we investigated the expressi...
Source: Biology of Reproduction - April 25, 2024 Category: Reproduction Medicine Authors: Zhiquan Liu Nan Zhang Chuangxin Wang Lina Shi Yixuan Hu Yamei Wang Jianzhen Li Source Type: research
Factors defining developmental competence of bovine oocytes collected for in vitro embryo production
Biol Reprod. 2024 Apr 25:ioae065. doi: 10.1093/biolre/ioae065. Online ahead of print.ABSTRACTDespite the currently relatively low effectiveness of producing bovine embryos in vitro, there is a growing interest in applying this laboratory method in the field of reproduction. Many aspects of the procedure need to be improved. One of the main problems is the inferior developmental competence of in vitro matured oocytes that are collected using the ovum pick-up (OPU) method. The mechanisms of oocyte capacitation and maturation, as well as the in vivo conditions in which they grow and mature, should be carefully analyzed. A del...
Source: Biology of Reproduction - April 25, 2024 Category: Reproduction Medicine Authors: Aleksandra Teresa Pytel Krystyna Żyżyńska-Galeńska Zdzis ław Gajewski Krzysztof Papis Source Type: research
Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation
AbstractInterleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such as gastric, colorectal, ovarian and breast cancer. Our group demonstrated that the IL-33/ST2 pathway enhances the development of squamous cell carcinoma (SCC). Conversely, other researchers have reported that IL-33 inhibits tumour progression. In addition, the crosstalk between IL-33, cancer cells and immune cells in SCC remains unknown. The aim of this study was to investigate the effect of IL-33 on the biology of head and neck SCC lines and to evaluate the impact of ...
Source: Cancer Immunology, Immunotherapy - April 25, 2024 Category: Cancer & Oncology Source Type: research
GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer
Oncogene, Published online: 25 April 2024; doi:10.1038/s41388-024-03040-1GSK3β and UCHL3 govern RIPK4 homeostasis via deubiquitination to enhance tumor metastasis in ovarian cancer (Source: Oncogene)
Source: Oncogene - April 25, 2024 Category: Cancer & Oncology Authors: Wulin Shan Wenju Peng Yao Chen Yumeng Wang Qiongli Yu Yuan Tian Yingyu Dou Jinqi Tu Xu Huang Xiaoyu Li Zengying Wang Qi Zhu Jiming Chen Bairong Xia Source Type: research
Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
AbstractExtrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since its discovery, in recent years, it has been found to have a close relationship with cancer, which has attracted widespread attention from researchers. Thus far, under the persistent research of researchers from all over the world, eccDNA has been found to play an important role in a variety of tumors, including breast cancer, lung cancer, ovarian cancer, etc. Herein, we review the sources of eccDNA, classifications, and the mechanisms responsible for their biogenesis....
Source: Clinical and Experimental Medicine - April 25, 2024 Category: Research Source Type: research
