Cancers, Vol. 16, Pages 1197: Harnessing ctDNA in Advanced Melanoma: A Promising Tool for Informed Clinical Decisions
s Urbonas
Cutaneous melanoma, an aggressive malignancy, has undergone significant transformation in clinical management with the introduction of immune checkpoint inhibitors (ICIs) and targeted therapies. Current monitoring methods, such as imaging scans, present limitations, prompting exploration of alternative biomarkers. This review comprehensively explores the role of circulating tumor DNA (ctDNA) in advanced melanoma, covering technical aspects, detection methods, and its prognostic and predictive value. Recent findings underscore ctDNA’s potential applications and implications in clinical practice. ...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Rugile Pikturniene Alvydas Cesas Sonata Jarmalaite Arturas Razbadauskas Vincas Urbonas Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1186: Natural Killer Cell Dysfunction in Premenopausal BRCA1 Mutation Carriers: A Potential Mechanism for Ovarian Carcinogenesis
Conclusions: Phase-specific differential NK cell activity in BRCA1 mutation carriers, either systemically or locally, may favor site-specific pre-invasive carcinogenesis. These cumulative effects across a reproductive lifecycle in high-risk carriers can have a detrimental effect further supporting epidemiological evidence for ovulation inhibition. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Shaun Haran Kantaraja Chindera May Sabry Nafisa Wilkinson Rupali Arora Agnieszka Zubiak Thomas E. Bartlett Iona Evans Allison Jones Daniel Reisel Chiara Herzog Twana Alkasalias Mark Newman Jaeyeon Kim Angelique Fl öter Rådestad Kristina Gemzell-Danielss Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1185: EMT Dynamics in Lymph Node Metastasis of Oral Squamous Cell Carcinoma
Conclusion: Our findings demonstrate that EMT marker expression correlates with lymph node metastasis in OSCC. Developing therapies targeting regulators such as N-cadherin may prevent metastasis and improve outcomes. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Yasmine Ghantous Shiraz Mozalbat Aysar Nashef Murad Abdol-Elraziq Shiran Sudri Shareef Araidy Hagar Tadmor Imad Abu El-naaj Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1187: Exercise Suppresses Head and Neck Squamous Cell Carcinoma Growth via Oncostatin M
hihata
Akihide Tanimoto
Major advances have been made in cancer treatment, but the prognosis for elderly cancer patients with sarcopenia and frailty remains poor. Myokines, which are thought to exert preventive effects against sarcopenia, have been reported to be associated with the prognosis of various cancers, but their effect on head and neck squamous cell carcinoma (HNSCC) is unknown. The aim of this study was to clarify the influence of exercise on the control of HNSCC and to examine the underlying mechanism involved. Mice were injected with HSC-3-M3 cells, a human cell line of highly metastatic and poorly diffe...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Takuya Yoshimura Yuka Hirano Taiji Hamada Seiya Yokoyama Hajime Suzuki Hirotaka Takayama Hirono Migita Takayuki Ishida Yasunori Nakamura Masahiro Ohsawa Akihiro Asakawa Kiyohide Ishihata Akihide Tanimoto Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1188: Investigating the Efficacy of EGFR-TKIs and Anti-VEGFR Combination in Advanced Non-Small Cell Lung Cancer: A Meta-Analysis
Conclusions: Our meta-analysis indicated EGFR-TKIs with anti-VEGFR in combination not only improved overall PFS but also showed similar results to a first line and first-generation agent compared to EGFR-TKI alone. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Prashant Sakharkar Sonali Kurup Subrata Deb Kaitlin Assaad Dayna Gesinski Erysa J. Gayle Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1189: Early Onset of Lung Cancer in Small Areas as a Signature of Point Pollution Sources
This study identified and measured the harmful effect of pollution in small areas by considering the early onset of LC as a signature of pollution. This novel method requires a Bayesian standard curve calculated from the median age at LC onset and the corresponding median age of reference populations. Similar medians gathered from the area/s under investigation permits a probabilistic comparison with the standard curve. Statistically significant divergences can be interpreted as early or late LC onset. The method is exemplified in the Trieste municipality (northeast Italy) using data from the Friuli Venezia Giulia Cancer R...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Ettore Bidoli Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1190: Responses to Medical Treatment in 192 Patients with Pancreatic Neuroendocrine Neoplasms Referred to the Copenhagen Neuroendocrine Tumour Centre in 2000 & ndash;2020
Conclusion: (1) Overall survival was, as expected, highly dependent on grade; (2) median PFS for SSA was around 2.5 years without difference between tumors with Ki-67 above or below 10%; (3) STZ/5FU as first-line treatment exhibited a superior mPFS of 20 months compared to what has historically been reported for targeted treatments; (4) PRRT in G2 pNEN achieved an mPFS similar to first-line chemotherapy; and (5) limited treatment efficacy was observed in high-grade tumors when treated with carboplatin and etoposide or temozolomide. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Sofie Skovlund Petersen Stine M øller Cecilie Slott Jesper Krogh Carsten Paln æs Hansen Andreas Kjaer Pernille Holmager Peter Oturai Rajendra Singh Garbyal Seppo W. Langer Ulrich Knigge Mikkel Andreassen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1191: Cancer Screening: Present Recommendations, the Development of Multi-Cancer Early Development Tests, and the Prospect of Universal Cancer Screening
escu
Cancer continues to pose a considerable challenge to global health. In the search for innovative strategies to combat this complex enemy, the concept of universal cancer screening has emerged as a promising avenue for early detection and prevention. In contrast to targeted approaches that focus on specific populations or high-risk individuals, universal screening seeks to cast a wide net to detect incipient malignancies in different demographic groups. This paradigm shift in cancer care underscores the importance of comprehensive screening programs that go beyond conventional boundaries. As our understanding of th...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Lauren ția Nicoleta Galeș Mihai-Andrei P ăun Rodica Maricela Anghel Oana Gabriela Trif ănescu Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1192: Comprehensive 3DCRT Hypofractionated Radiotherapy Schedule for Localized Prostate Adenocarcinoma in the Era of IMRT: Dosimetric and Endoscopic Analysis
Conclusions: A thorough delineation of the rectal wall and its subsegments, together with the dosimetric analysis of these structures, may reduce late rectal toxicity. Dosimetric parameters such as V52.17Gy and V56.52Gy were identified to have a significant impact on rectal mucosal injury; additional dose endpoint validation and its relation to late GI toxicity is needed. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Andromachi Kougioumtzopoulou Nick Syrigos Anna Zygogianni Ioannis Georgakopoulos Kalliopi Platoni George Patatoukas Kimon Tzannis Aristotelis Bamias Nikolaos Kelekis Vasileios Kouloulias Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1193: The Added Value of Transcatheter CT Hepatic Angiography (CTHA) Image Guidance in Percutaneous Thermal Liver Ablation: An Experts & rsquo; Opinion Pictorial Essay
Cancers, Vol. 16, Pages 1193: The Added Value of Transcatheter CT Hepatic Angiography (CTHA) Image Guidance in Percutaneous Thermal Liver Ablation: An Experts’ Opinion Pictorial Essay
Cancers doi: 10.3390/cancers16061193
Authors:
Puijk
Dijkstra
van der Lei
Schulz
Vos
Timmer
Geboers
Scheffer
de Vries
Smits
Bruijnen
Deschamps
de Baère
Odisio
Meijerink
With the rapidly evolving field of image-guided tumor ablation, there is an increasing demand and need for tools to optimize treatment success. Known factors affecting the success of (non-)thermal liver ablation proc...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Puijk Dijkstra van der Lei Schulz Vos Timmer Geboers Scheffer de Vries Smits Bruijnen Deschamps de Ba ère Odisio Meijerink Tags: Opinion Source Type: research
Cancers, Vol. 16, Pages 1194: Cachexia-Affected Survival Based on Inflammatory Parameters Compared to Complex Conventional Nutritional Assessments in Patients with Pancreatic Cancer and Other Gastrointestinal Tumors & mdash;The CONKO 020 Investigation
Conclusion: Specifically for PDAC patients, high inflammatory index and albumin serum levels potentially represent a sufficient early surrogate marker to detect patients at high risk of impaired OS better than complex conventional methods. These findings could help to identify patients who may benefit from early therapeutic interventions. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Johanna W. Meyer-Knees Janina Falkenthal Dominik Geisel Christopher C. M. Neumann Georg Hilfenhaus Lars U. Stephan Wenzel Sch öning Thomas Malinka Johann Pratschke Sebastian Stintzing Uwe Pelzer Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1195: CD44 in Bladder Cancer
scu
The glycoprotein CD44, with its many isoforms and variations in carbohydrate patterning, participates in a diverse set of cellular functions. This fact leads to the protein playing a role in many normal and pathologic cellular processes including a role in cancer progression and metastasis. These same facts make CD44 a strong therapeutic target in many cancer types, including bladder cancer. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Jason Duex Dan Theodorescu Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1196: Efficacy of NSCLC Rechallenge with Immune Checkpoint Inhibitors Following Disease Progression or Relapse
s Kotteas
Immune checkpoint inhibitors (ICIs) are at the forefront of advanced non-small-cell lung cancer (NSCLC) treatment. Still, only 27–46% of patients respond to initial therapy with ICIs, and of those, up to 65% develop resistance within four years. After disease progression (PD), treatment options are limited, with 10% Objective Response Rate (ORR) to second or third-line chemotherapy. In this context, ICI rechallenge is an appealing option for NSCLC. Most data on the efficacy of ICI rechallenge are based on retrospective real-world studies of small, heavily pretreated, and heterogeneous patient gr...
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Maria Effrosyni Livanou Vasiliki Nikolaidou Vasileios Skouras Oraianthi Fiste Elias Kotteas Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1181: Correction: Huang et al. Systemic Anticoagulation and Inpatient Outcomes of Pancreatic Cancer: Real-World Evidence from U.S. Nationwide Inpatient Sample. Cancers 2023, 15, 1985
eng
Li-Sung Hsu
In the original publication [...] (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Yen-Min Huang Hsuan-Jen Shih Yi-Chan Chen Tsan-Yu Hsieh Che-Wei Ou Po-Hsu Su Shih-Ming Chen Yun-Cong Zheng Li-Sung Hsu Tags: Correction Source Type: research
Cancers, Vol. 16, Pages 1182: Systemic Chemotherapy in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery: Systematic Review and Meta-Analysis
Conclusions. Systemic chemotherapy administration in patients undergoing radical surgery for colorectal peritoneal metastases is associated with increased survival only in the adjuvant/post-operative setting. Considering the limitations of the included studies, further trials are needed to answer this unresolved question. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Marco Tonello Carola Cenzi Elisa Pizzolato Riccardo Fiscon Paola Del Bianco Pierluigi Pilati Antonio Sommariva Tags: Systematic Review Source Type: research