Cancers, Vol. 16, Pages 1696: Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions
abbro
Despite a better understanding of the mechanisms causing cancer cachexia (CC) and development of promising pharmacologic and supportive care interventions, CC persists as an underdiagnosed and undertreated condition. CC contributes to fatigue, poor quality of life, functional impairment, increases treatment related toxicity, and reduces survival. The core elements of CC such as weight loss and poor appetite should be identified early. Currently, addressing contributing conditions (hypothyroidism, hypogonadism, and adrenal insufficiency), managing nutrition impact symptoms leading to decreased oral intake (nausea,...
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Sudeep Pandey Lauren Bradley Egidio Del Fabbro Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1697: A Review of the Paradigmatic Role of Adipose Tissue in Renal Cancer: Fat Measurement and Tumor Behavior Features
Conclusions: Methodological variations and limitations, such as retrospective designs and sample size constraints, pose challenges to standardization and generalizability. Further research is needed to understand these associations better and establish standardized approaches for adiposity assessment in RCC patients, which could inform clinical practice and therapeutic decision-making. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Eliodoro Faiella Elva Vergantino Federica Vaccarino Amalia Bruno Gloria Perillo Rosario Francesco Grasso Bruno Beomonte Zobel Domiziana Santucci Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1698: Identifying the Trends of Urinary microRNAs within Extracellular Vesicles for Esophageal Cancer
Conclusions: The current study identified the urinary microRNAs which were significantly expressed in ESCC patients. Validation study is warranted to evaluate whether these microRNAs could reflect tumor burden during multidisciplinary treatment for ESCC. (Source: Cancers)
Source: Cancers - April 27, 2024 Category: Cancer & Oncology Authors: Kazuhiko Hisaoka Satoru Matsuda Kodai Minoura Hiroki Yamaguchi Yuki Ichikawa Mika Mizunuma Ryota Kobayashi Yosuke Morimoto Masashi Takeuchi Kazumasa Fukuda Rieko Nakamura Shutaro Hori Taigi Yamazaki Takehiko Sambe Hirofumi Kawakubo Yuko Kitagawa Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1690: Current and Future Therapeutic Targets for Directed Molecular Therapies in Cholangiocarcinoma
andulski
We conducted a comprehensive review of the current literature of published data, clinical trials (MEDLINE; ncbi.pubmed.com), congress contributions (asco.org; esmo.org), and active recruiting clinical trains (clinicaltrial.gov) on targeted therapies in cholangiocarcinoma. Palliative treatment regimens were analyzed as well as preoperative and perioperative treatment options. We summarized the current knowledge for each mutation and molecular pathway that is or has been under clinical evaluation and discussed the results on the background of current treatment guidelines. We established and recommended targeted ...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Philipp Heumann Andreas Albert Karsten G ülow Denis T ümen Martina M üller Arne Kandulski Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1691: Update in the Treatment of Pleural Tumors: Robotic Surgery Combined with Hyperthermic Intrathoracic Chemotherapy
Conclusion: With the limitation of the small number of patients, robotic surgery in combination with HITHOC seems to be safe in patients with pleural relapses of thymoma and early-stage MPM. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Romano Zirafa Ceccarelli Elia Davini Melfi Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1692: The Association between Blood Test Trends and Undiagnosed Cancer: A Systematic Review and Critical Appraisal
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Brian D. Nicholson
Clinical guidelines include monitoring blood test abnormalities to identify patients at increased risk of undiagnosed cancer. Noting blood test changes over time may improve cancer risk stratification by considering a patient’s individual baseline and important changes within the normal range. We aimed to review the published literature to understand the association between blood test trends and undiagnosed cancer. MEDLINE and EMBASE were searched until 15 May 2023 for studies assessing the association between blood test trends and undiagnosed cancer. We used descriptive summaries ...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Pradeep S. Virdee Kiana K. Collins Claire Friedemann Smith Xin Yang Sufen Zhu Sophie E. Roberts Nia Roberts Jason L. Oke Clare Bankhead Rafael Perera FD Richard Hobbs Brian D. Nicholson Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1693: Genomic Characterization of Partial Tandem Duplication Involving the KMT2A Gene in Adult Acute Myeloid Leukemia
Conclusions: KMT2A-PTDs are complex gene rearrangements that cannot be fully ascertained using a single genomic platform. MLPA, NGS panels, and OGM are complementary technologies applied in standard-of-care testing for AML patients. MLPA and NGS panels are designed for targeted copy number analysis; however, our results showed that integration of concurrent genomic alterations is needed for accurate KMT2A-PTD identification. Unbalanced chromosomal rearrangements overlapping with KMT2A can interfere with the diagnostic sensitivity and specificity of copy-number-based KMT2A-PTD detection methodologies. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Andrew Seto Gregory Downs Olivia King Shabnam Salehi-Rad Ana Baptista Kayu Chin Sylvie Grenier Bevoline Nwachukwu Anne Tierens Mark D. Minden Adam C. Smith Jos é-Mario Capo-Chichi Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1694: Proton Therapy in Non-Rhabdomyosarcoma Soft Tissue Sarcomas of Children and Adolescents
asanova
Ferrari
This paper provides insights into the use of Proton Beam Therapy (PBT) in pediatric patients with non-rhabdomyosarcoma soft tissue sarcomas (NRSTS). NRSTS are a heterogeneous group of rare and aggressive mesenchymal extraskeletal tumors, presenting complex and challenging clinical management scenarios. The overall survival rate for patients with NRSTS is around 70%, but the outcome is strictly related to the presence of various variables, such as the histological subtype, grade of malignancy and tumor stage at diagnosis. Multimodal therapy is typically considered the preferred treatment for high-grad...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Vennarini Colombo Mirandola Orlandi Pecori Chiaravalli Massimino Casanova Ferrari Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1695: Synergistic Action of Benzyl Isothiocyanate and Sorafenib in a Nanoparticle Delivery System for Enhanced Triple-Negative Breast Cancer Treatment
ing Bao
Triple-negative breast cancer (TNBC) presents a therapeutic challenge due to its complex pathology and limited treatment options. Addressing this challenge, our study focuses on the effectiveness of combination therapy, which has recently become a critical strategy in cancer treatment, improving therapeutic outcomes and combating drug resistance and metastasis. We explored a novel combination therapy employing Benzyl isothiocyanate (BITC) and Sorafenib (SOR) and their nanoformulation, aiming to enhance therapeutic outcomes against TNBC. Through a series of in vitro assays, we assessed the cytotoxic effects of B...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Qi Wang Nan Cheng Wei Wang Yongping Bao Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1672: Joint-Sparing Resection around the Knee for Osteosarcoma: Long-Term Outcomes of Biologic Reconstruction with Vascularized Fibula Graft Combined with Massive Allograft
Conclusions: VFG represents an effective reconstructive option after joint-sparing intercalary resection around the knee for osteosarcoma. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Roberto Scanferla Federico Scolari Francesco Muratori Angela Tamburini Luca Delcroix Guido Scoccianti Giovanni Beltrami Marco Innocenti Domenico Andrea Campanacci Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1673: COVID-19 and Cancer Detection in Russia
In this study, we analyzed the impact of the expected reduction in screening intensity on morbidity and mortality from certain malignancies. Cumulative data from the Russian National Cancer Registry available from 2000 to 2022 were analyzed. It was noted that there has been no noticeable effect of the COVID-19 lockdowns on mortality rates from breast, prostate, renal, or thyroid cancers. At the same time, the detectable incidence decreased markedly in 2020 at the time of the lockdowns and then returned to pre-pandemic levels in 2022. At the moment, there is no sufficient reason to believe that skipping screening tests in 2...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Andrey Sudarikov Tags: Communication Source Type: research
Cancers, Vol. 16, Pages 1674: Deciphering the Role of BCAR3 in Cancer Progression: Gene Regulation, Signal Transduction, and Therapeutic Implications
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This review comprehensively explores the gene BCAR3, detailing its regulation at the gene, mRNA, and protein structure levels, and delineating its multifunctional roles in cellular signaling within cancer contexts. The discussion covers BCAR3’s involvement in integrin signaling and its impact on cancer cell migration, its capability to induce anti-estrogen resistance, and its significant functions in cell cycle regulation. Further highlighted is BCAR3’s modulation of immune responses within the tumor microenvironment, a novel area of interest that holds potential for innovative cancer ther...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Dong Oh Moon Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1675: Intestinal Microbiome Associated with Efficacy of Atezolizumab and Bevacizumab Therapy for Hepatocellular Carcinoma
In this study, we analyzed fecal samples collected before treatment to investigate the relationship between the intestinal microbiome and the efficacy of atezolizumab and bevacizumab. A total of 37 patients with advanced HCC who were treated with atezolizumab and bevacizumab were enrolled. Fecal samples were collected from the patients, and they were divided into responder (n = 28) and non-responder (n = 9) groups. We compared the intestinal microbiota of the two groups and analyzed the intestinal bacteria associated with prognosis using QIIME2. The alpha and beta diversities were not significantly different between both g...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Yosuke Inukai Kenta Yamamoto Takashi Honda Shinya Yokoyama Takanori Ito Norihiro Imai Yoji Ishizu Masanao Nakamura Masatoshi Ishigami Hiroki Kawashima Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1678: Proteins Involved in Focal Cell Adhesion and Podosome Formation Are Differentially Expressed during Colorectal Tumorigenesis in AOM-Treated Rats
sak
Colorectal tumorigenesis involves the development of aberrant crypt foci (ACF) or preneoplastic lesions, representing the earliest morphological lesion visible in colon cancer. The purpose of this study was to determine changes in protein expression in carcinogen-induced ACF as they mature and transform into adenomas. Protein expression profiles of azoxymethane (AOM)-induced F344 rat colon ACF and adenomas were compared at four time points, 4 (control), 8, 16, and 24 weeks post AOM administration (n = 9/group), with time points correlating with induction and transformation events. At each time point, micro-dissecte...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Ian X. Swain Adam M. Kresak Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1677: Internet Access and Use by Patients with Gynecologic Malignancies: A Cross-Sectional Study
In conclusion, the predominant majority of gynecologic cancer patients can be reached by modern internet-based E-Health technologies. (Source: Cancers)
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Frederik Bach David Engelhardt Christoph A. Mallmann Sina Tamir Lars Schr öder Christian M. Domr öse Michael R. Mallmann Tags: Article Source Type: research
