Cancers, Vol. 15, Pages 4824: Automated Cellular-Level Dual Global Fusion of Whole-Slide Imaging for Lung Adenocarcinoma Prognosis
In this study, we present a fully automated cellular-level dual global fusion pipeline for survival prediction. Specifically, the proposed method first describes the composition of different cell populations on WSI. Then, it generates dimension-reduced WSI-embedded maps, allowing for efficient investigation of the tumor microenvironment. In addition, we introduce a novel dual global fusion network to incorporate global and inter-patch features of cell distribution, which enables the sufficient fusion of different types and locations of cells. We further validate the proposed pipeline using The Cancer Genome Atlas lung aden...
Source: Cancers - October 1, 2023 Category: Cancer & Oncology Authors: Songhui Diao Pingjun Chen Eman Showkatian Rukhmini Bandyopadhyay Frank R. Rojas Bo Zhu Lingzhi Hong Muhammad Aminu Maliazurina B. Saad Morteza Salehjahromi Amgad Muneer Sheeba J. Sujit Carmen Behrens Don L. Gibbons John V. Heymach Neda Kalhor Ignacio I. W Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4825: Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment
Alessandra Rosati
Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies. (Source: Cancers)
Source: Cancers - October 1, 2023 Category: Cancer & Oncology Authors: Anna Lisa Cammarota Antonia Falco Anna Basile Carlo Molino Massimiliano Chetta Gianni D ’Angelo Liberato Marzullo Margot De Marco Maria Caterina Turco Alessandra Rosati Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4826: Evaluating Stacked Methylation Markers for Blood-Based Multicancer Detection
. Altman
Laura Elnitski
The ability to detect several types of cancer using a non-invasive, blood-based test holds the potential to revolutionize oncology screening. We mined tumor methylation array data from the Cancer Genome Atlas (TCGA) covering 14 cancer types and identified two novel, broadly-occurring methylation markers at TLX1 and GALR1. To evaluate their performance as a generalized blood-based screening approach, along with our previously reported methylation biomarker, ZNF154, we rigorously assessed each marker individually or combined. Utilizing TCGA methylation data and applying logistic regression model...
Source: Cancers - October 1, 2023 Category: Cancer & Oncology Authors: Karen Funderburk Sara R. Bang-Christensen Brendan F. Miller Hua Tan Gennady Margolin Hanna M. Petrykowska Catherine Baugher S. Katie Farney Sara A. Grimm Nader Jameel David O. Holland Naomi S. Altman Laura Elnitski Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4827: Deep Learning for Automatic Diagnosis and Morphologic Characterization of Malignant Biliary Strictures Using Digital Cholangioscopy: A Multicentric Study
Guilherme Macedo
Digital single-operator cholangioscopy (D-SOC) has enhanced the ability to diagnose indeterminate biliary strictures (BSs). Pilot studies using artificial intelligence (AI) models in D-SOC demonstrated promising results. Our group aimed to develop a convolutional neural network (CNN) for the identification and morphological characterization of malignant BSs in D-SOC. A total of 84,994 images from 129 D-SOC exams in two centers (Portugal and Spain) were used for developing the CNN. Each image was categorized as either a normal/benign finding or as malignant lesion (the latter dependent on histopathol...
Source: Cancers - October 1, 2023 Category: Cancer & Oncology Authors: Miguel Mascarenhas Saraiva Tiago Ribeiro Mariano Gonz ález Bel én Agudo Castillo Jo ão P. S. Ferreira Filipe Vilas Boas Jo ão Afonso Francisco Mendes Miguel Martins Pedro Cardoso Pedro Pereira Guilherme Macedo Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4814: The Landscape of Adoptive Cellular Therapies in Ovarian Cancer
Wong
Ovarian cancers are typically poorly immunogenic and have demonstrated disappointing responses to immune checkpoint inhibitor (ICI) therapy. Adoptive cellular therapy (ACT) offers an alternative method of harnessing the immune system that has shown promise, especially with the success of chimeric antigen receptor T-cell (CAR-T) therapy in haematologic malignancies. So far, ACT has led to modest results in the treatment of solid organ malignancies. This review explores the possibility of ACT as an effective alternative or additional treatment to current standards of care in ovarian cancer. We will highlight the po...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Lucy Davis Rowan E Miller Yien Ning Sophia Wong Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4816: TP53 Mutation in Acute Myeloid Leukemia: An Old Foe Revisited
Conclusions: Developing an effective treatment strategy for TP53-mutated AML through innovative and multidisciplinary research is an urgent task. Directly targeting mutated TP53 holds promise as an approach to combating TP53-mutated AML, and recent developments in immunologic agents for AML offer hope in this field. (Source: Cancers)
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Dong-Yeop Shin Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4817: Radiation Therapy for Gestational Trophoblastic Neoplasia: Forward-Looking Lessons Learnt
i
Giorgia Mangili
Gestational trophoblastic neoplasia (GTN) includes several rare malignant diseases occurring after pregnancy: invasive moles, choriocarcinoma, placental site trophoblastic tumours, and epithelioid trophoblastic tumours. Multidisciplinary protocols including multi-agent chemotherapy, surgery, and occasionally radiotherapy achieve good outcomes for some high-risk metastatic patients. In this narrative review of the published studies on the topic, we have tried to identify the role of radiotherapy. The available studies are mainly small, old, and retrospective, with incomplete data regarding radiothera...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Amelia Barcellini Andrei Fodor Alexandra Charalampopoulou Chiara Cassani Laura Deborah Locati Raffaella Cioffi Alice Bergamini Sandro Pignata Ester Orlandi Giorgia Mangili Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4819: Unraveling the Role of Molecular Profiling in Predicting Treatment Response in Stage III Colorectal Cancer Patients: Insights from the IDEA International Study
Conclusions: Molecular characterization of tumor cells can enhance our understanding of the disease course. Mutations may serve as promising prognostic biomarkers, offering improved treatment options. Confirming these findings will require larger patient cohorts and international collaborations to establish correlations between molecular profiling, clinicopathological and epidemiological characteristics and clinical outcomes. (Source: Cancers)
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Ippokratis Messaritakis Eleni Psaroudaki Konstantinos Vogiatzoglou Maria Sfakianaki Pantelis Topalis Ioannis Iliopoulos Dimitrios Mavroudis John Tsiaoussis Nikolaos Gouvas Maria Tzardi John Souglakos Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4821: Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett & rsquo;s Esophagus
Cancers, Vol. 15, Pages 4821: Differential Expression of NEK Kinase Family Members in Esophageal Adenocarcinoma and Barrett’s Esophagus
Cancers doi: 10.3390/cancers15194821
Authors:
Lei Chen
Farah Ballout
Heng Lu
Tianling Hu
Shoumin Zhu
Zheng Chen
Dunfa Peng
The incidence of esophageal adenocarcinoma (EAC) has risen rapidly during the past four decades, making it the most common type of esophageal cancer in the USA and Western countries. The NEK (Never in mitosis A (NIMA) related kinase) gene family is a group of serine/threonine kinases with 11 members. Aberrant expression of NEKs has been re...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Lei Chen Farah Ballout Heng Lu Tianling Hu Shoumin Zhu Zheng Chen Dunfa Peng Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4818: Taxifolin Inhibits the Growth of Non-Small-Cell Lung Cancer via Downregulating Genes Displaying Novel and Robust Associations with Immune Evasion Factors
il Kapoor
Damu Tang
Using an LL2 cell-based syngeneic mouse LC model, taxifolin suppressed allografts along with the appearance of 578 differentially expressed genes (DEGs). These DEGs were associated with enhancement of processes related to the extracellular matrix and lymphocyte chemotaxis as well as the reduction in pathways relevant to cell proliferation. From these DEGs, we formulated 12-gene (TxflSig) and 7-gene (TxflSig1) panels; both predicted response to ICB (immune checkpoint blockade) therapy more effectively in non-small-cell lung cancer (NSCLC) than numerous well-established ICB biomarkers, including PD-...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Xiaozeng Lin Ying Dong Yan Gu Fengxiang Wei Jingyi Peng Yingying Su Yanjun Wang Chengzhi Yang Sandra Vega Neira Anil Kapoor Damu Tang Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4820: The Risk of Colorectal Polyps after Weight Loss Therapy Versus Obesity: A Propensity-Matched Nationwide Cohort Study
Conclusions: Obesity is associated with an increased risk of colorectal polyps, an effect that is ameliorated after bariatric surgery. These data are relevant for studies investigating colorectal carcinogenesis mechanisms. (Source: Cancers)
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Hisham Hussan Eric McLaughlin Chienwei Chiang Joseph G. Marsano David Lieberman Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4822: PACS-Integrated Tools for Peritumoral Edema Volumetrics Provide Additional Information to RANO-BM-Based Assessment of Lung Cancer Brain Metastases after Stereotactic Radiotherapy: A Pilot Study
In this study, we aimed to compare volumetric changes of edema to RANO-BM-based measurements of contrast-enhancing lesion size. Patients with NSCLC METS ≥10 mm on post-contrast T1-weighted image and treated with SRT had measurements for up to seven follow-up scans using a PACS-integrated tool segmenting the peritumoral FLAIR hyperintense volume. Two-dimensional contrast-enhancing and volumetric edema changes were compared by creating treatment response curves. Fifty NSCLC METS were included in the study. The initial median peritumoral edema volume post-SRT relative to pre-SRT baseline was 37% (IQR 8&ndas...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Manpreet Kaur Gabriel Cassinelli Petersen Leon Jekel Marc von Reppert Sunitha Varghese Irene Dixe de Oliveira Santo Arman Avesta Sanjay Aneja Antonio Omuro Veronica Chiang Mariam Aboian Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4823: Real-World Effectiveness, Safety, and Health-Related Quality of Life in Patients Receiving Adjuvant Nivolumab for Melanoma in Belgium and Luxembourg: Results of PRESERV MEL
Conclusions: These results confirm the real-world effectiveness and safety of nivolumab as an adjuvant treatment for patients with completely resected stage III or stage IV melanoma. Cancer-specific, disease-specific, and generic HRQoL were maintained during and after treatment. The percentage of patients reporting emotional and cognitive impairment increased after treatment cessation, emphasizing the need for further investigation and tailored supportive care in these patients. (Source: Cancers)
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Anne Rogiers Laurence Willemot Laura McDonald Hilde Van Campenhout Guy Berchem Celine Jacobs Nathalie Blockx Andr ée Rorive Bart Neyns Tags: Article Source Type: research
Cancers, Vol. 15, Pages 4810: The Role of Non-Coding RNAs in Myelodysplastic Neoplasms
chael
Myelodysplastic syndromes or neoplasms (MDS) are a heterogeneous group of myeloid clonal disorders characterized by peripheral blood cytopenias, blood and marrow cell dysplasia, and increased risk of evolution to acute myeloid leukemia (AML). Non-coding RNAs, especially microRNAs and long non-coding RNAs, serve as regulators of normal and malignant hematopoiesis and have been implicated in carcinogenesis. This review presents a comprehensive summary of the biology and role of non-coding RNAs, including the less studied circRNA, siRNA, piRNA, and snoRNA as potential prognostic and/or predictive biomarkers or thera...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Vasileios Georgoulis Epameinondas Koumpis Eleftheria Hatzimichael Tags: Review Source Type: research
Cancers, Vol. 15, Pages 4812: Exploring Possible Diagnostic Precancerous Biomarkers for Oral Submucous Fibrosis: A Narrative Review
Chia-Yu Wu
I-Ta Lee
Oral submucous fibrosis (OSF) stands as a progressive oral ailment, designated as a potentially malignant disorder. OSF has gained widespread recognition as a significant precursor to malignant transformation. In the pursuit of dependable, straightforward, and non-invasive diagnostic measures for the early detection of oral malignant progression, research has delved into potential diagnostic biomarkers of OSF. This comprehensive review delves into current investigations that explore the correlation between various biomarkers and OSF. The molecular biomarkers of OSF are categorized based on cytolog...
Source: Cancers - September 30, 2023 Category: Cancer & Oncology Authors: Jie-Ru You Ya-Ting Chen Chia-Yu Hsieh Sin-Yu Chen Tzu-Yao Lin Jing-Syuan Shih Guan-Ting Chen Sheng-Wei Feng Tzu-Yu Peng Chia-Yu Wu I-Ta Lee Tags: Review Source Type: research
