Cancers, Vol. 14, Pages 567: Impact of Progressive Site-Directed Therapy in Oligometastatic Castration-Resistant Prostate Cancer on Subsequent Treatment Response
ra Yasuhisa Fujii The purpose of this study was to evaluate the impact of progressive site-directed therapy (PSDT) for oligometastatic castration-resistant prostate cancer (OM-CRPC) on the efficacy of subsequent androgen receptor axis-targeted (ARAT) drugs, and to demonstrate the possibility of prolonging overall survival (OS). We performed a retrospective analysis of 15 OM-CRPC patients who underwent PSDT and subsequently received first-line ARAT drugs (PSDT group) and 13 OM-CRPC patients who were treated with first-line ARAT drugs without PSDT (non-PSDT group). PSDT was performed with the intention of treating all ...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Soichiro Yoshida Taro Takahara Yuki Arita Kazuma Toda Koichiro Kimura Hajime Tanaka Minato Yokoyama Yoh Matsuoka Ryoichi Yoshimura Yasuhisa Fujii Tags: Article Source Type: research

Cancers, Vol. 14, Pages 572: AKT1 Is Required for a Complete Palbociclib-Induced Senescence Phenotype in BRAF-V600E-Driven Human Melanoma
ip W. Hinds Cellular senescence is a carefully regulated process of proliferative arrest accompanied by functional and morphologic changes. Senescence allows damaged cells to avoid neoplastic proliferation; however, the induction of the senescence-associated secretory phenotype (SASP) can promote tumor growth. The complexity of senescence may limit the efficacy of anti-neoplastic agents, such as CDK4/6 inhibitors (Cdk4/6i), that induce a senescence-like state in tumor cells. The AKT kinase family, which contains three isoforms that play both unique and redundant roles in cancer progression, is commonly hyperactive in m...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Abraham L. Bayer Jodie Pietruska Jaymes Farrell Siobhan McRee Pilar Alcaide Philip W. Hinds Tags: Article Source Type: research

Cancers, Vol. 14, Pages 573: High Dose Thoracic Re-Irradiation and Chemo-Immunotherapy for Centrally Recurrent NSCLC
Conclusion: The evidence regarding curative re-irradiation for centrally recurrent NSCLC is primarily based on scarce retrospective data, which are characterized by a high degree of heterogeneity. The OS in this clinically challenging situation is expected to be around 1.5 years after re-treatment. Patients with a good performance score, younger age, small tumors, and a longer interval to recurrence potentially benefit most from re-irradiation. In this context, prospective trials are warranted to achieve substantial advances in the field. (Source: Cancers)
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Brane Grambozov Markus Stana Bernhard Kaiser Josef Karner Sabine Gerum Elvis Ruznic Barbara Zellinger Raphaela Moosbrugger Michael Studnicka Gerd Fastner Felix Sedlmayer Franz Zehentmayr Tags: Review Source Type: research

Cancers, Vol. 14, Pages 574: Oral Contraceptive Use and Breast Cancer Risk According to Molecular Subtypes Status: A Systematic Review and Meta-Analysis of Case-Control Studies
bert Rejdak We conducted a systematic review and meta-analysis to investigate the effect of oral contraceptives (OCs) on risk of breast cancer (BrCa) by status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). We searched the MEDLINE (PubMed), Embase and the Cochrane Library database and bibliographies of pertinent articles published up to 2020. Therein, we identified nineteen eligible case-control studies which provided data by breast cancer subtypes: ER-positive (ER+), ER-negative (ER−), HER2-positive (HER2+) and Triplet-negative (TN). Summary ri...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Agnieszka Bara ńska Joanna Dolar-Szczasny Wies ław Kanadys Wiktoria Kinik Dorota Ceglarska Urszula Religioni Robert Rejdak Tags: Systematic Review Source Type: research

Cancers, Vol. 14, Pages 562: Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer
In conclusion, our data suggests that breast tumor metabolism is regulated by the host’s physiological status, such as obesity and diabetes. (Source: Cancers)
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Caner Yelek Lionel Mignion Adrien Paquot Caroline Bouzin Cyril Corbet Giulio G. Muccioli Patrice D. Cani B énédicte F. Jordan Tags: Article Source Type: research

Cancers, Vol. 14, Pages 564: High-Definition Ultrasound Characterization of Squamous Carcinoma of the Tongue: A Descriptive Observational Study
ta Lucchese High-definition ultrasonography is a diagnostic tool that uses sound echoes to produce images of tissues and organs. In the head and neck region, ultrasounds have been used to diagnose different types of lesions. The intraoral approach was shown to be a real-time, non-invasive way to characterize oral lesions. The tongue is the most often examined region because of its accessibility. This observational study aimed to describe the qualitative characteristics of tongue squamous cell carcinoma images obtained with high-definition intraoral ultrasound by comparing them with the corresponding histopathological s...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Dario Di Di Stasio Marco Montella Antonio Romano Giuseppe Colella Rosario Serpico Alberta Lucchese Tags: Article Source Type: research

Cancers, Vol. 14, Pages 565: Characteristics and Outcome of Elderly Patients ( & gt;55 years) with Acute Lymphoblastic Leukemia
Cancers, Vol. 14, Pages 565: Characteristics and Outcome of Elderly Patients (>55 years) with Acute Lymphoblastic Leukemia Cancers doi: 10.3390/cancers14030565 Authors: Daniela V. Wenge Klaus Wethmar Corinna A. Klar Hedwig Kolve Tim Sauer Linus Angenendt Georg Evers Simon Call Andrea Kerkhoff Cyrus Khandanpour Torsten Kessler Rolf Mesters Christoph Schliemann Jan-Henrik Mikesch Christian Reicherts Monika Brüggemann Wolfgang E. Berdel Georg Lenz Matthias Stelljes Prognosis of elderly ALL patients remains dismal. Here, we retrospectively analyzed the course of 93 patients &...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Daniela V. Wenge Klaus Wethmar Corinna A. Klar Hedwig Kolve Tim Sauer Linus Angenendt Georg Evers Simon Call Andrea Kerkhoff Cyrus Khandanpour Torsten Kessler Rolf Mesters Christoph Schliemann Jan-Henrik Mikesch Christian Reicherts Monika Br üggemann Wol Tags: Article Source Type: research

Cancers, Vol. 14, Pages 566: Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts
In conclusion, exosome-capturing Ab-conjugated siRNAs with branched Arg linkers can be effectively delivered into MM cells via uptake of exosomes by parental cells. This technology has the potential to lead to a breakthrough in drug delivery systems for hematologic cancers. (Source: Cancers)
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Emi Soma Asako Yamayoshi Yuki Toda Yuji Mishima Shigekuni Hosogi Eishi Ashihara Tags: Article Source Type: research

Cancers, Vol. 14, Pages 568: Genetic Landscape of Multistep Hepatocarcinogenesis
sawa Seno Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. Although several targeted therapy agents are available for advanced HCC, their antitumor efficacy remains limited. As the complex genetic landscape of HCC would compromise the antitumor efficacy of targeted therapy, a deeper understanding of the genetic landscape of hepatocarcinogenesis is necessary. Recent comprehensive genetic analyses have revealed the driver genes of HCC, which accumulate during the multistage process of hepatocarcinogenesis, facilitating HCC genetic heterogeneity. In addition, as early genetic changes ...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Takeda Takai Eso Takahashi Marusawa Seno Tags: Review Source Type: research

Cancers, Vol. 14, Pages 569: Adrenal Mass Characterization in the Era of Quantitative Imaging: State of the Art
oyer Anthony Dohan Detection and characterization of adrenal lesions have evolved during the past two decades. Although the role of imaging in adrenal lesions associated with hormonal secretion is usually straightforward, characterization of non-functioning adrenal lesions may be challenging to confidently identify those that need to be resected. Although many adrenal lesions can be readily diagnosed when they display typical imaging features, the diagnosis may be challenging for atypical lesions. Computed tomography (CT) remains the cornerstone of adrenal imaging, but other morphological or functional modalities can...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Maxime Barat Anne-S égolène Cottereau S ébastien Gaujoux Florence Tenenbaum Mathilde Sibony J érôme Bertherat Rossella Lib é Martin Gaillard Anne Jouinot Guillaume Assi é Christine Hoeffel Philippe Soyer Anthony Dohan Tags: Review Source Type: research

Cancers, Vol. 14, Pages 570: Review of Regional Therapies for Gastric Cancer with Peritoneal Metastases
Lee Gastric cancer carries a poor prognosis and is a leading cause of cancer-related mortality worldwide. Patients with gastric cancer who develop peritoneal metastases have an even more dismal prognosis, with median survival time measured in months. Since studies have demonstrated that systemic chemotherapy has poor penetration into the peritoneum, multimodal treatment with intraperitoneal chemotherapy has been proposed for the treatment of peritoneal metastases and has become the foundation for newer therapeutic techniques and clinical trials. These include heated intraperitoneal chemotherapy (HIPEC) with cytoreducti...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Beatrice J. Sun Byrne Lee Tags: Review Source Type: research

Cancers, Vol. 14, Pages 563: Implications of Stemness Features in 1059 Hepatocellular Carcinoma Patients from Five Cohorts: Prognosis, Treatment Response, and Identification of Potential Compounds
In this study, five HCC cohorts with 1059 patients were collected to calculate transcriptional stemness indexes (mRNAsi) by the one-class logistic regression machine learning algorithm. In the TCGA-LIHC cohort, we found mRNAsi was an independent prognostic factor, and 626 mRNAsi-related genes were identified by Spearman correlation analysis. The HCC stemness risk model (HSRM) was trained in the TCGA-LIHC cohort and significantly discriminated overall survival in four independent cohorts. HSRM was also significantly associated with transarterial chemoembolization treatment response and rapid tumor growth in HCC patients. Co...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Haoming Mai Haisheng Xie Mengqi Luo Jia Hou Jiaxuan Chen Jinlin Hou De-Ke Jiang Tags: Article Source Type: research

Cancers, Vol. 14, Pages 571: Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers
e Therapy with T cells equipped with chimeric antigen receptors (CARs) shows strong efficacy against leukaemia and lymphoma, but not yet against solid cancers. This has been attributed to insufficient T cell persistence, tumour heterogeneity and an immunosuppressive tumour microenvironment. The present article provides an overview of key strategies that are currently investigated to overcome these hurdles. Basic aspects of CAR design are revisited, relevant for tuning the stimulatory signal to the requirements of solid tumours. Novel approaches for enhancing T cell persistence are highlighted, based on epigenetic or po...
Source: Cancers - January 23, 2022 Category: Cancer & Oncology Authors: Jon Amund Kyte Tags: Review Source Type: research

Cancers, Vol. 14, Pages 550: Recent Advanced in the Treatment of Advanced SCC Tumors
bec Squamous cell carcinoma (SCC) is the second most frequent form of skin cancer after basal cell carcinoma. While most SCC can be treated by surgery or radiotherapy, some progress into an advanced form and are no longer suitable for these treatments. Guidelines and staging systems have help to define these advanced SCC (aSCC), for which prognosis was very poor until recently. Platin-based chemotherapy was traditionally used, but few prospective trials and no treatment regimen was recommended. Furthermore, toxicity in elderly patients limited its use. The development of immunotherapy has improved the prognosis of thes...
Source: Cancers - January 22, 2022 Category: Cancer & Oncology Authors: Nicole Basset-Seguin Eve Maubec Tags: Commentary Source Type: research

Cancers, Vol. 14, Pages 551: Kras Gene Analysis Using Liquid-Based Cytology Specimens Predicts Therapeutic Responses and Prognosis in Patients with Pancreatic Cancer
Conclusions: The analysis of the Kras gene status could be used to predict therapeutic responses to GA and prognosis in unresectable PDAC patients. (Source: Cancers)
Source: Cancers - January 22, 2022 Category: Cancer & Oncology Authors: Masahiro Itonaga Reiko Ashida Shin-Ichi Murata Yasunobu Yamashita Keiichi Hatamaru Takashi Tamura Yuki Kawaji Yuudai Kayama Tomoya Emori Manabu Kawai Hiroki Yamaue Ibu Matsuzaki Hirokazu Nagai Yuichi Kinoshita Ke Wan Toshio Shimokawa Masayuki Kitano Tags: Article Source Type: research