Cancers, Vol. 16, Pages 1386: Evaluating Leukocyte Telomere Length and Myeloid-Derived Suppressor Cells as Biomarkers for Prostate Cancer
Conclusions: Our research has established a correlation between LTL and MDSC in patients undergoing biopsy for prostate cancer. Notably, we observed that individuals with localized prostate cancer tend to have shorter LTL and a higher percentage of M-MDSC prior to their diagnosis. These findings suggest that LTL and M-MDSC could potentially serve as adjunctive biomarkers for the early diagnosis of prostate cancer. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Haruhiko Wakita Yan Lu Xiaoxu Li Takuro Kobayashi Tsuyoshi Hachiya Hisamitsu Ide Shigeo Horie Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1387: Oncogenic STAT Transcription Factors as Targets for Cancer Therapy: Innovative Strategies and Clinical Translation
A. Frank
Despite advances in our understanding of molecular aspects of oncogenesis, cancer remains a leading cause of death. The malignant behavior of a cancer cell is driven by the inappropriate activation of transcription factors. In particular, signal transducers and activators of transcription (STATs), which regulate many critical cellular processes such as proliferation, apoptosis, and differentiation, are frequently activated inappropriately in a wide spectrum of human cancers. Multiple signaling pathways converge on the STATs, highlighting their importance in the development and progression of oncogenic disease...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Weiyuan Wang Melanie Cristina Lopez McDonald Rajashree Hariprasad Tiara Hamilton David A. Frank Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1373: Long-Term Oral Tamoxifen Administration Decreases Brain-Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats
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Mary Ellen Kelly
Tamoxifen, a selective estrogen receptor modulator (SERM), is commonly used as an adjuvant drug therapy for estrogen-receptor-positive breast cancers. Though effective at reducing the rate of cancer recurrence, patients often report unwanted cognitive and affective side effects. Despite this, the impacts of chronic tamoxifen exposure on the brain are poorly understood, and rodent models of tamoxifen exposure do not replicate the chronic oral administration seen in patients. We, therefore, used long-term ad lib consumption of medicated food pellets to model chronic tamoxifen exposure in a clinica...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Laura E. Been Amanda R. Halliday Sarah M. Blossom Elena M. Bien Anya G. Bernhard Grayson E. Roth Karina I. Domenech Rosario Karlie B. Pollock Petra E. Abramenko Leily M. Behbehani Gabriel J. Pascal Mary Ellen Kelly Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1374: MGMT Methylation and Differential Survival Impact by Sex in Glioblastoma
Conclusions: In this study, females had higher mean and individual CpG site methylation and received a greater PFS and OS benefit by MGMT methylation that was not seen in males despite equal degrees of CpG methylation. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Addison E. Barnett Ahmad Ozair Anas S. Bamashmos Hong Li David S. Bosler Gabrielle Yeaney Assad Ali David M. Peereboom Justin D. Lathia Manmeet S. Ahluwalia Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1375: Aggressive Angiomyxoma of the Lower Female Genital Tract: A Review of the MITO Rare Tumors Group
Gennaro Cormio
Aggressive angiomyxoma (AAM) is a rare, locally aggressive, myxoid mesenchymal neoplasm primarily found in the pelvic and perineal regions of young adult females. It is a slow growing and locally infiltrating tumor. Preoperative diagnosis is difficult due to the rarity of these tumors and absence of characteristic signs and symptoms. The primary management is tumor excision. Incomplete excision is common because of the infiltrating nature of the neoplasm and absence of a definite capsule. Other non- surgical modalities have been employed, such as radiotherapy, embolization, GnRH analogues or other anti-...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Miriam Dellino Francescapaola Magazzino Lavinia Domenici Stefania Cicogna Salvatora Tindara Miano Sandro Pignata Giorgia Mangili Gennaro Cormio Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1376: Posterior and Para-Aortic (D2plus) Lymphadenectomy after Neoadjuvant/Conversion Therapy for Locally Advanced/Oligometastatic Gastric Cancer
azzei
Franco Roviello
Super-extended (D2plus) lymphadenectomy after chemotherapy has been reported in only a few studies. This retrospective study evaluates survival outcomes in a Western cohort of locally advanced or oligometastatic gastric cancer patients who underwent D2plus lymphadenectomy after neoadjuvant chemotherapy. A total of 97 patients treated between 2010 and 2022 were included. Of these, 62 had clinical stage II/III disease, and 35 had stage IV disease. Most patients (65%) received preoperative DOC/FLOT chemotherapy. The mean number of lymph nodes harvested was 39. Pathological positive nodes in the pos...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Daniele Marrelli Stefania Angela Piccioni Ludovico Carbone Roberto Petrioli Maurizio Costantini Valeria Malagnino Giulio Bagnacci Gabriele Rizzoli Natale Calomino Riccardo Piagnerelli Maria Antonietta Mazzei Franco Roviello Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1377: The Role of Circulating Tumor Cells as a Liquid Biopsy for Cancer: Advances, Biology, Technical Challenges, and Clinical Relevance
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Cancer remains a leading cause of mortality worldwide, with metastasis significantly contributing to its lethality. The metastatic spread of tumor cells, primarily through the bloodstream, underscores the importance of circulating tumor cells (CTCs) in oncological research. As a critical component of liquid biopsies, CTCs offer a non-invasive and dynamic window into tumor biology, providing invaluable insights into cancer dissemination, disease progression, and response to treatment. This review article delves into the recent advancements in CTC research, highlighting their emerging role as a biomarker in various can...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Tyler A. Allen Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1378: Chemotherapy Plus Atezolizumab Pre- and Post-Resection in Localized Esophageal or Gastroesophageal Junction Adenocarcinomas: A Phase I/II Single-Arm Study
arry Lyons
Norelle Reilly
James C. Yao
Jaffer A. Ajani
Mariela Blum Murphy
Efforts to improve the prognosis for patients with locally advanced esophageal or gastroesophageal junction (GEJ) adenocarcinoma have focused on neoadjuvant approaches to increase the pathological complete response (pathCR) rate, improve surgical resection, and prolong event-free and overall survival (OS). Building on the recent evidence that PD-1 inhibition plus chemotherapy improves the OS of patients with metastatic GEJ adenocarcinoma, we evaluated whether the application of this strategy in the neoadjuvant setting would improve the p...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Matheus Sewastjanow-Silva Lianchun Xiao Graciela N. Gonzalez Xuemei Wang Wayne Hofstetter Stephen Swisher Reza Mehran Boris Sepesi Manoop S. Bhutani Brian Weston Emmanuel Coronel Rebecca E. Waters Jane E. Rogers Jackie Smith Larry Lyons Norelle Reilly Jam Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1379: Advancing GCT Management: A Review of miR-371a-3p and Other miRNAs in Comparison to Traditional Serum Tumor Markers
Aditya Bagrodia
MicroRNAs, short non-protein coding RNAs, are overexpressed in GCTs. Circulating levels of germ cell tumor (GCT)-associated miRNAs, such as miR-371a-3p, can be utilized as efficient and cost-effective alternatives in diagnosing and managing patients presenting with GCTs. This quality of miRNAs has demonstrated favorable performance characteristics as a reliable blood-based biomarker with high diagnostic accuracy compared to current serum tumor markers (STMs), including α-fetoprotein (AFP), beta human chorionic gonadotropin (β-hCG), and lactate dehydrogenase (LDH). The conven...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Crystal L. Seales Dhruv Puri Nuphat Yodkhunnatham Kshitij Pandit Kit Yuen Sarah Murray Jane Smitham John T. Lafin Aditya Bagrodia Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1381: Role of the Atypical MAPK ERK3 in Cancer Growth and Progression
Long
Extracellular signal-regulated kinase 3 (ERK3) is an atypical mitogen-activated protein kinase (MAPK) whose structural and regulatory features are distinct from those of conventional MAPKs, such as ERK1/2. Since its identification in 1991, the regulation, substrates and functions of ERK3 have remained largely unknown. However, recent years have witnessed a wealth of new findings about ERK3 signaling. Several important biological functions for ERK3 have been revealed, including its role in neuronal morphogenesis, inflammation, metabolism, endothelial cell tube formation and epithelial architecture. In addition, ER...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Lobna Elkhadragy Amanda Myers Weiwen Long Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1380: Outpatient Palliative Care Program: Impact on Home Death Rate in Brazil
This study sought to determine the impact of an outpatient palliative care (OPC) program on the location of death among patients in Brazil. This was a retrospective study including patients with cancer who died between January 2022 and December 2022 in 32 private cancer centers in Brazil. Data were collected from medical records, encompassing demographics, cancer characteristics, and participation in the OPC program. The study involved 1980 patients, of which 32.3% were in the OPC program. OPC patients were predominantly younger (average age at death of 66.8 vs. 68.0 years old, p = 0.039) and composed of women (59.4% vs. 5...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Sarah Ananda Gomes Danielle Nunes Moura Silva Flavia Sorice Alexandra Arantes Rafaela Peixoto Renata Ferrari Matheus Martins Alexandre J ácome Cristiane Bergerot Andreia Cristina de Melo Bruno Ferrari Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1382: Increased Pituitary Fluorine-18-Fluorodeoxyglucose Uptake in Patients with Differentiated Thyroid Cancer in Hypothyroidism versus under Recombinant Human Thyroid-Stimulating Hormone Stimulation
Conclusions: The present findings support the hypothesis that pituitary hypermetabolism on 18F-FDG PET/CT in patients with DTC undergoing THW is a common physiological response to hypothyroidism. Awareness of this physiological hypermetabolism is important to avoid potential pitfalls in image interpretation. (Source: Cancers)
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Xinyi Shi Ilaria Giordani Marie Nicod Lalonde Gerasimos P. Sykiotis Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1383: Clinical and Therapeutic Intervention of Hypereosinophilia in the Era of Molecular Diagnosis
g Zhang
Hypereosinophilia (HE) presents with an elevated peripheral eosinophilic count of >1.5 × 109/L and is composed of a broad spectrum of secondary non-hematologic disorders and a minority of primary hematologic processes with heterogenous clinical presentations, ranging from mild symptoms to potentially lethal outcome secondary to end-organ damage. Following the introduction of advanced molecular diagnostics (genomic studies, RNA sequencing, and targeted gene mutation profile, etc.) in the last 1–2 decades, there have been deep insights into the etiology and molecular mechani...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Lynh Nguyen Aditi Saha Andrew Kuykendall Ling Zhang Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1384: Lonidamine Induced Selective Acidification and De-Energization of Prostate Cancer Xenografts: Enhanced Tumor Response to Radiation Therapy
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Kavindra Nath
Prostate cancer is a multi-focal disease that can be treated using surgery, radiation, androgen deprivation, and chemotherapy, depending on its presentation. Standard dose-escalated radiation therapy (RT) in the range of 70–80 Gray (GY) is a standard treatment option for prostate cancer. It could be used at different phases of the disease (e.g., as the only primary treatment when the cancer is confined to the prostate gland, combined with other therapies, or as an adjuvant treatment after surgery). Unfortunately, RT for prostate cancer is associated with gastro-intestinal and genitourina...
Source: Cancers - March 31, 2024 Category: Cancer & Oncology Authors: Stepan Orlovskiy Pradeep Kumar Gupta Jeffrey Roman Fernando Arias-Mendoza David S. Nelson Cameron J. Koch Vivek Narayan Mary E. Putt Kavindra Nath Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1368: FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden
In conclusion, agonism of FXR by primary bile acid memetic OCA yields potent anti-tumor effects potentially through inhibition of proliferation and migration and reduced cell viability. These findings suggest that FXR is a tumor suppressor gene with a high potential for use in personalized therapeutic strategies for individuals with BC. (Source: Cancers)
Source: Cancers - March 30, 2024 Category: Cancer & Oncology Authors: Sydney C. Joseph Samson Eugin Simon Margaret S. Bohm Minjeong Kim Madeline E. Pye Boston W. Simmons Dillon G. Graves Stacey M. Thomas-Gooch Ubaid A. Tanveer Jeremiah R. Holt Suriyan Ponnusamy Laura M. Sipe D. Neil Hayes Katherine L. Cook Ramesh Narayanan Tags: Article Source Type: research
