Cancers, Vol. 16, Pages 1692: The Association between Blood Test Trends and Undiagnosed Cancer: A Systematic Review and Critical Appraisal

Cancers, Vol. 16, Pages 1692: The Association between Blood Test Trends and Undiagnosed Cancer: A Systematic Review and Critical Appraisal Cancers doi: 10.3390/cancers16091692 Authors: Pradeep S. Virdee Kiana K. Collins Claire Friedemann Smith Xin Yang Sufen Zhu Sophie E. Roberts Nia Roberts Jason L. Oke Clare Bankhead Rafael Perera FD Richard Hobbs Brian D. Nicholson Clinical guidelines include monitoring blood test abnormalities to identify patients at increased risk of undiagnosed cancer. Noting blood test changes over time may improve cancer risk stratification by considering a patient’s individual baseline and important changes within the normal range. We aimed to review the published literature to understand the association between blood test trends and undiagnosed cancer. MEDLINE and EMBASE were searched until 15 May 2023 for studies assessing the association between blood test trends and undiagnosed cancer. We used descriptive summaries and narratively synthesised studies. We included 29 articles. Common blood tests were haemoglobin (24%, n = 7), C-reactive protein (17%, n = 5), and fasting blood glucose (17%, n = 5), and common cancers were pancreatic (29%, n = 8) and colorectal (17%, n = 5). Of the 30 blood tests studied, an increasing trend in eight (27%) was associated with eight cancer types, and a decreasing trend in 17 (57%) with 10 cancer types. No association was reported between trends in 11 (37%) tests and breast,...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Systematic Review Source Type: research