Intramural Papers of the Month
<img width="100" src="https://factor.niehs.nih.gov/sites/niehs-factor/files/styles/large/public/thumb825983.jpg?itok=otjNGPEU" /><br /><p>National Toxicology Program (NTP) researchers and collaborators evaluated the usefulness of quantitative high-throughput approaches to assess the genotoxicity, or the ability to cause DNA damage, of compounds in the Tox21 library of 10,000 compounds. To do this, they assessed p53 activity in human colon cancer cells (HCT-116). p53 is a transcription factor that is activated in response to cellular stress, particularly DNA damage.</p> (read mor...
Source: Environmental Factor - NIEHS Newsletter - February 3, 2023 Category: Environmental Health Source Type: news

Epigenetics holds key to link between obesity and colorectal cancer
<img width="100" src="https://factor.niehs.nih.gov/sites/niehs-factor/files/styles/large/public/2018/2/feature/feature-2-obesity/thumb838460.jpg?itok=GAfvRoHS" /><br /><p>In a new study, cells in the guts of obese mice showed epigenetic changes that may promote colorectal cancer.</p> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - February 3, 2023 Category: Environmental Health Source Type: news

Oncologist takes on early-onset colorectal cancer
<img width="100" src="https://factor.niehs.nih.gov/sites/niehs-factor/files/styles/large/public/2018/4/science-highlights/colorectal/thumb843817.jpg?itok=DiR5PeV3" /><br /><p>Oncologist Thomas Weber discussed the rise of early-onset colorectal cancer and suggested environmental factors may play a role.</p> (read more) (Source: Environmental Factor - NIEHS Newsletter)
Source: Environmental Factor - NIEHS Newsletter - February 3, 2023 Category: Environmental Health Source Type: news

Monitoring ctDNA After Colorectal Cancer Surgery Monitoring ctDNA After Colorectal Cancer Surgery
Cell-free DNA concentration is significantly increased in the first 2 weeks after surgery but these higher levels do not seem to interfere with monitoring of circulating tumor DNA for prognostic purposes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 2, 2023 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

[Ad hoc announcement pursuant to Art. 53 LR] Roche reports good results for 2022 despite decline in demand for COVID-19 products
Basel, 2 February 2023Group sales grow by 2%1 at constant exchange rates (CER) and 1% in Swiss francs, despite lower COVID-19-related sales in both divisionsPharmaceuticals Division salesincrease by 2%; continued strong growth of newer medicines more than compensating for the impact of biosimilars and lower sales of Actemra/RoActemra (severe COVID-19)Diagnostics Division salesgrow by 3%; ongoing strong momentum in base business (+7%) more than compensating for the continuing decline in the demand for COVID-19 tests in the second half of the yearHighlightsin the fourth quarter of 2022 (incl. January 2023):US approvals ofLun...
Source: Roche Media News - February 2, 2023 Category: Pharmaceuticals Source Type: news

[Ad hoc announcement pursuant to Art. 53 LR] Roche reports good results for 2022 despite decline in demand for COVID-19 products
Group sales grow by 2%1 at constant exchange rates (CER) and 1% in Swiss francs, despite lower COVID-19-related sales in both divisionsPharmaceuticals Division salesincrease by 2%; continued strong growth of newer medicines more than compensating for the impact of biosimilars and lower sales of Actemra/RoActemra (severe COVID-19)Diagnostics Division salesgrow by 3%; ongoing strong momentum in base business (+7%) more than compensating for the continuing decline in the demand for COVID-19 tests in the second half of the yearHighlightsin the fourth quarter of 2022 (incl. January 2023):US approvals ofLunsumio (follicular lymp...
Source: Roche Investor Update - February 2, 2023 Category: Pharmaceuticals Source Type: news

Neoadjuvant Oxaliplatin-Fluoropyrimidine Chemo Improves Colon Cancer Outcomes
WEDNESDAY, Feb. 1, 2023 -- Six weeks of preoperative oxaliplatin-fluoropyrimidine chemotherapy is safe and effective for operable colon cancer, without increasing perioperative morbidity, according to a study published online Jan. 19 in the Journal... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 1, 2023 Category: Pharmaceuticals Source Type: news

New Treatment Recommendations for Early-Onset CRC New Treatment Recommendations for Early-Onset CRC
An international group of physicians has issued a list of 31 treatment recommendations for patients diagnosed with early-onset colorectal cancer (before 50 years of age).MDedge News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 31, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Negative Fecal Tests Tied to Low Risk for Advanced Colorectal Cancer
TUESDAY, Jan. 31, 2023 -- There was a low risk for advanced neoplasia after multiple rounds of negative fecal immunochemical tests (FIT) in people undergoing surveillance colonoscopy, according to a study published online Jan. 4 in Clinical... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 31, 2023 Category: Pharmaceuticals Source Type: news

Deep Learning Model Aids Differentiation of Colon Cancer, Acute Diverticulitis
FRIDAY, Jan. 27, 2023 -- A three-dimensional (3-D) convolutional neural network (CNN) can be used as an artificial intelligence (AI) support system for differentiating colon carcinoma (CC) and acute diverticulitis (AD) on computed tomography (CT)... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 27, 2023 Category: Pharmaceuticals Source Type: news

Enkyboys' Randy Gonzalez told fans chemo was " not working " before his death
Randy Gonzalez, one half of the popular duo in the Enkyboys TikTok account, told fans his chemotherapy wasn't working just weeks before he died. Gonzalez passed away on Wednesday at age 35, a little more than a year after being diagnosed with colon cancer. The Enkyboys duo of Randy and his son…#randygonzalez #enkyboys #tiktok #gonzalez #brice #vivienacevedofonse #christopherperez #blackpanther #chadwickboseman #colorectal (Source: Reuters: Health)
Source: Reuters: Health - January 26, 2023 Category: Consumer Health News Source Type: news

Has The Obesity Epidemic Gotten Out Of Hand In America?
Obesity is linked to a number of health ailments, including diabetes, heart disease, stroke, and a number of cancers such as breast and colorectal. If that wasn ’t enough, the annual medical cost of obesity was nearly 173 billion dollars in 2019 alone. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - January 25, 2023 Category: Pharmaceuticals Authors: Omer Awan, Contributor Tags: Healthcare /healthcare Innovation /innovation Source Type: news

pks+ Escherichia Coli and Development of Colorectal Cancer pks+ Escherichia Coli and Development of Colorectal Cancer
This large meta-analysis aimed to determine whether individuals carrying pks+ E. coli have a greater risk of developing colorectal cancer.Laboratory Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 25, 2023 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news

Neoadjuvant Chemo Reduces Disease Recurrence in Operable Colon Cancer
(MedPage Today) -- Six weeks of neoadjuvant chemotherapy for patients with operable colon cancer is safe and results in downstaging, increased complete resection rates, and better disease control at 2 years, according to results from the randomized... (Source: MedPage Today Surgery)
Source: MedPage Today Surgery - January 24, 2023 Category: Surgery Source Type: news

Record waits for endoscopy as referrals soar
The waiting list for endoscopies has broken the record set during the height of the covid pandemic, as referrals for suspected colorectal cancer surged, HSJ analysis shows. (Source: HSJ)
Source: HSJ - January 24, 2023 Category: UK Health Source Type: news