Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1
Res Sq [Preprint]. 2024 Mar 5:rs.3.rs-4009459. doi: 10.21203/rs.3.rs-4009459/v1.ABSTRACTCisplatin and oxaliplatin cause the secretion of high mobility group box 1 (HMGB1) from cancer cells, which is necessary for initiation of immunogenic cell death (ICD). Calreticulin (CRT) translocation from the endoplasmic reticulum to the plasma membrane is also required; oxaliplatin induces this translocation but cisplatin does not. We have discovered that oxaliplatin causes the secretion of both HMGB1 and HMGB2 from the nucleus into the extracellular milieu. We previously showed that cisplatin mediated secretion of HMGB1 is controlle...
Source: Cell Research - March 18, 2024 Category: Cytology Authors: Ian Blair Jingqi Fan Kevin Gillespie Clementina Mesaros Source Type: research

Molecular engineering of a spheroid-penetrating phage nanovector for photodynamic treatment of colon cancer cells
Cell Mol Life Sci. 2024 Mar 17;81(1):144. doi: 10.1007/s00018-024-05174-7.ABSTRACTPhotodynamic therapy (PDT) represents an emerging strategy to treat various malignancies, including colorectal cancer (CC), the third most common cancer type. This work presents an engineered M13 phage retargeted towards CC cells through pentavalent display of a disulfide-constrained peptide nonamer. The M13CC nanovector was conjugated with the photosensitizer Rose Bengal (RB), and the photodynamic anticancer effects of the resulting M13CC-RB bioconjugate were investigated on CC cells. We show that upon irradiation M13CC-RB is able to impair ...
Source: Cellular and Molecular Life Sciences : CMLS - March 18, 2024 Category: Cytology Authors: Eleonora Turrini Luca Ulfo Paolo Emidio Costantini Roberto Saporetti Matteo Di Giosia Michela Nigro Annapaola Petrosino Lucia Pappagallo Alena Kaltenbrunner Andrea Cantelli Valentina Pellicioni Elena Catanzaro Carmela Fimognari Matteo Calvaresi Alberto Da Source Type: research

Targeted inhibition of colorectal cancer proliferation: The  dual-modulatory role of 2,4-DTBP on anti-apoptotic Bcl-2 and Survivin proteins
In this study, we employed both in silico and in vitro methodologies to underpin this interaction at the molecular level. Molecular docking demonstrated a substantial binding affinity of 2,4-DTBP towards Bcl-2 (ΔG = -9.8 kcal/mol) and Survivin (ΔG = -5.6 kcal/mol), suggesting a potential inhibitory effect. Further, molecular dynamic simulations complemented by MM-GBSA calculations confirmed the significant binding of 2,4-DTBP with Bcl-2 (dGbind = -54.85 ± 6.79 kcal/mol) and Survivin (dGbind = -32.36 ± 1.29 kcal/mol). In vitro assays using HCT116 colorectal cancer cells revealed that 2,4-DTBP inhibited proliferation and...
Source: J Cell Mol Med - March 18, 2024 Category: Molecular Biology Authors: Partha Saha Mangala Hegde Kanak Chakraborty Achinta Singha Nobendu Mukerjee Deepshikha Ghosh Ajaikumar B Kunnumakkara Mohd Shahnawaz Khan Md Irshad Ahmad Arabinda Ghosh Ajoy Kumer Samir Kumar Sil Source Type: research

Targeted inhibition of colorectal cancer proliferation: The  dual-modulatory role of 2,4-DTBP on anti-apoptotic Bcl-2 and Survivin proteins
In this study, we employed both in silico and in vitro methodologies to underpin this interaction at the molecular level. Molecular docking demonstrated a substantial binding affinity of 2,4-DTBP towards Bcl-2 (ΔG = -9.8 kcal/mol) and Survivin (ΔG = -5.6 kcal/mol), suggesting a potential inhibitory effect. Further, molecular dynamic simulations complemented by MM-GBSA calculations confirmed the significant binding of 2,4-DTBP with Bcl-2 (dGbind = -54.85 ± 6.79 kcal/mol) and Survivin (dGbind = -32.36 ± 1.29 kcal/mol). In vitro assays using HCT116 colorectal cancer cells revealed that 2,4-DTBP inhibited proliferation and...
Source: Molecular Medicine - March 18, 2024 Category: Molecular Biology Authors: Partha Saha Mangala Hegde Kanak Chakraborty Achinta Singha Nobendu Mukerjee Deepshikha Ghosh Ajaikumar B Kunnumakkara Mohd Shahnawaz Khan Md Irshad Ahmad Arabinda Ghosh Ajoy Kumer Samir Kumar Sil Source Type: research

Cancer-specific dose and fractionation schedules in stereotactic body radiotherapy for oligometastatic disease: An interim analysis of the EORTC-ESTRO E2-RADIatE OligoCare study
Stereotactic body radiotherapy (SBRT) has become a standard-of-care in the multidisciplinary management of patients with oligometastatic disease (OMD) [1]. Today, definitive local treatment of distant metastases is recommended in several National Comprehensive Cancer Network (NCCN) guidelines, for example, for colorectal cancer (CRC), non-small cell lung cancer (NSCLC), renal cell cancer, sarcoma, and selected pediatric malignancies [2 –4]. Consequently, the use of SBRT in patients with OMD has markedly increased and is commonplace in many radiation oncology centers around the world nowadays. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - March 18, 2024 Category: Radiology Authors: Sebastian M. Christ, Filippo Alongi, Umberto Ricardi, Marta Scorsetti, Lorenzo Livi, Panagiotis Balermpas, Yolande Lievens, P ètra Braam, Barbara Alicja Jereczek-Fossa, Karin Stellamans, Ivica Ratosa, Joachim Widder, Heike Peulen, Piet Dirix, Samuel Bral Tags: Original Article Source Type: research

Interleukin-12: Structure, Function, and Its Impact in Colorectal Cancer
Journal of Interferon&Cytokine Research, Ahead of Print. (Source: Journal of Interferon)
Source: Journal of Interferon - March 18, 2024 Category: Research Authors: Ziwei Zhu Qian Peng Xingmei Duan Jie Li Source Type: research

Social Determinants of Health and the Link to Colorectal Cancer Outcomes
Opinion   statementColorectal cancer (CRC) remains the second most deadly cancer in the United States, behind only lung cancer. Despite improvements in incidence due to screening and mortality in part due to better treatments, there are some groups that have not seen these promising changes. American Indian/Alaska Native and non-Hispanic Black individuals, certain geographic regions, and lower socioeconomic groups have all been shown to have worse CRC outcomes. A significant body of evidence has linked these disparities in outcomes to social determinants of health (SDH). SDH are defined by the WHO as “the non-medical fa...
Source: Current Treatment Options in Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research

Prophylactic defunctioning stomas improve clinical outcomes of anastomotic leak following rectal cancer resections: An analysis of the US Rectal Cancer Consortium
ConclusionLack of DLI and preoperative weight loss was associated with anastomotic leak. Fecal diversion may improve the timely initiation of adjuvant oncologic therapy. The long-term outcomes following routine diverting stomas warrant further study. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - March 18, 2024 Category: Gastroenterology Source Type: research

TGF β signalling pathway impacts brain metastases profiles in locally advanced colorectal cancer
ConclusionOur results suggest the TGF β pathway as a crucial player in the development of brain metastases in primary CRC. In some types of colorectal cancer, downregulation of the TGFβ pathway might hinder primary colorectal cancer to metastasize to the nervous system. While the paradoxical functioning of the TGFβ pathway is still n ot fully understood, these shed light on yet another clinical implication of this complex pathway. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 18, 2024 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 16, Pages 1192: Comprehensive 3DCRT Hypofractionated Radiotherapy Schedule for Localized Prostate Adenocarcinoma in the Era of IMRT: Dosimetric and Endoscopic Analysis
Conclusions: A thorough delineation of the rectal wall and its subsegments, together with the dosimetric analysis of these structures, may reduce late rectal toxicity. Dosimetric parameters such as V52.17Gy and V56.52Gy were identified to have a significant impact on rectal mucosal injury; additional dose endpoint validation and its relation to late GI toxicity is needed. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Andromachi Kougioumtzopoulou Nick Syrigos Anna Zygogianni Ioannis Georgakopoulos Kalliopi Platoni George Patatoukas Kimon Tzannis Aristotelis Bamias Nikolaos Kelekis Vasileios Kouloulias Tags: Article Source Type: research

Cancers, Vol. 16, Pages 1182: Systemic Chemotherapy in Colorectal Peritoneal Metastases Treated with Cytoreductive Surgery: Systematic Review and Meta-Analysis
Conclusions. Systemic chemotherapy administration in patients undergoing radical surgery for colorectal peritoneal metastases is associated with increased survival only in the adjuvant/post-operative setting. Considering the limitations of the included studies, further trials are needed to answer this unresolved question. (Source: Cancers)
Source: Cancers - March 18, 2024 Category: Cancer & Oncology Authors: Marco Tonello Carola Cenzi Elisa Pizzolato Riccardo Fiscon Paola Del Bianco Pierluigi Pilati Antonio Sommariva Tags: Systematic Review Source Type: research

Association between the gut microbiota, inflammatory factors, and colorectal cancer: evidence from Mendelian randomization analysis
ConclusionUsing MR analysis, this study revealed the causal relationships between the gut microbiota, IFs, and CRC. The negative correlation between the Lachnospiraceae species in the gut and CRC risk, as well as the causal relationship between IL-10 and CRC, provide important clues for the potential roles of gut microbiota regulation and inflammatory factor control in the prevention and treatment of CRC. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 18, 2024 Category: Microbiology Source Type: research

Magnetic natural lipid nanoparticles for oral treatment of colorectal cancer through potentiated antitumor immunity and microbiota metabolite regulation
Biomaterials. 2024 Mar 11;307:122530. doi: 10.1016/j.biomaterials.2024.122530. Online ahead of print.ABSTRACTThe therapeutic efficacy of oral nanotherapeutics against colorectal cancer (CRC) is restricted by inadequate drug accumulation, immunosuppressive microenvironment, and intestinal microbiota imbalance. To overcome these challenges, we elaborately constructed 6-gingerol (Gin)-loaded magnetic mesoporous silicon nanoparticles and functionalized their surface with mulberry leaf-extracted lipids (MLLs) and Pluronic F127 (P127). In vitro experiments revealed that P127 functionalization and alternating magnetic fields (AMF...
Source: Biomaterials - March 17, 2024 Category: Materials Science Authors: Baoyi Li Menghang Zu Aodi Jiang Yingui Cao Jiaxue Wu Mohammad-Ali Shahbazi Xiaoxiao Shi Rui L Reis Subhas C Kundu Bo Xiao Source Type: research

Selective activation of IFN γ-ipilimumab enhances the therapeutic effect and safety of ipilimumab
CONCLUSION: IFNγ-ipilimumab improved the effectiveness of ipilimumab while reducing its side effects. It is likely that future immunotherapies would rely on such antibodies to activate local cancer cells or immune cells, thereby increasing the therapeutic effectiveness of cancer treatments and ensuring their safety.PMID:38493818 | DOI:10.1016/j.ijbiomac.2024.130945 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 17, 2024 Category: Biochemistry Authors: Yi-Jung Huang Kai-Wen Ho Tian-Lu Cheng Yen-Tseng Wang Shi-Wei Chao Bo-Cheng Huang Yu-Shu Chao Chia-Yu Lin Yun-Han Hsu Fang-Ming Chen Chih-Hung Chuang Source Type: research

Decreased interleukin ‐17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice
ConclusionReduced IL-17RA expression also suppressed cellular proliferation, migration, and invasion, and the expression of EMT genes. Knockdown of IL-17RA inhibited tumor growth and vascularity and decreased the population of Tregs and MDSCs in mouse tumors. Overall, IL-17RA expression was identified to be independently associated with the prognosis of patients with CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - March 17, 2024 Category: Cancer & Oncology Authors: Jeng ‐Kai Jiang, Chi‐Hung Lin, Ting‐An Chang, Liang‐Chuan Lo, Chien‐Ping Lin, Ruey‐Hwa Lu, Chih‐Yung Yang Tags: RESEARCH ARTICLE Source Type: research