Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management
World J Gastroenterol. 2024 Apr 7;30(13):1780-1790. doi: 10.3748/wjg.v30.i13.1780.ABSTRACTColorectal cancer (CRC) has remained the second and the third leading cause of cancer-related death worldwide and in the United States, respectively. Although significant improvement in overall survival has been achieved, death in adult populations under the age of 55 appears to have increased in the past decades. Although new classes of therapeutic strategies such as immunotherapy have emerged, their application is very limited in CRC so far. Microtubule (MT) inhibitors such as taxanes, are not generally successful in CRC. There may ...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Katsuhiro Kita Allen Burdowski Source Type: research
Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
World J Gastroenterol. 2024 Apr 7;30(13):1815-1835. doi: 10.3748/wjg.v30.i13.1815.ABSTRACTColorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable. Over the past decade, cancer treatment has significantly improved with the introduction of cancer immunotherapies, specifically immune checkpoint inhibitors. Therapies aimed at blocking imm...
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Source Type: research
Engaging with Rural Communities for Colorectal Cancer Screening Outreach Using Modified Boot Camp Translation
CONCLUSIONS: Using a modified version of BCT delivered in a virtual format, we were able to successfully capture community input to adapt a CRC outreach program for use in rural settings. Program materials will be tested during a pragmatic trial to address rural CRC screening disparities.PMID:38661826 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Jennifer Coury Gloria D Coronado Emily Myers Mary Patzel Jamie Thompson Courtney Whidden-Rivera Melinda M Davis Source Type: research
Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
World J Gastroenterol. 2024 Apr 7;30(13):1815-1835. doi: 10.3748/wjg.v30.i13.1815.ABSTRACTColorectal cancer (CRC) is a complex disease with diverse etiologies and clinical outcomes. Despite considerable progress in development of CRC therapeutics, challenges remain regarding the diagnosis and management of advanced stage metastatic CRC (mCRC). In particular, the five-year survival rate is very low since mCRC is currently rarely curable. Over the past decade, cancer treatment has significantly improved with the introduction of cancer immunotherapies, specifically immune checkpoint inhibitors. Therapies aimed at blocking imm...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Samantha Sharma Naresh Singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda Julia Lily Dong Xinna Zhang Mateusz Opyrchal Source Type: research
Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management
World J Gastroenterol. 2024 Apr 7;30(13):1780-1790. doi: 10.3748/wjg.v30.i13.1780.ABSTRACTColorectal cancer (CRC) has remained the second and the third leading cause of cancer-related death worldwide and in the United States, respectively. Although significant improvement in overall survival has been achieved, death in adult populations under the age of 55 appears to have increased in the past decades. Although new classes of therapeutic strategies such as immunotherapy have emerged, their application is very limited in CRC so far. Microtubule (MT) inhibitors such as taxanes, are not generally successful in CRC. There may ...
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Katsuhiro Kita Allen Burdowski Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - April 25, 2024 Category: Gastroenterology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Association between Atherosclerosis and High-Risk Colorectal Adenomas based on Cardio-Ankle Vascular Index and Ankle-Brachial Index
CONCLUSIONS: In this study, a significant correlation between positive CAVI and high-risk adenomas was observed. Therefore, CAVI may be a significant predictor for high-risk colorectal adenoma.PMID:38659250 | DOI:10.4166/kjg.2024.003 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Jung Ho Lee Hyunseok Cho Sang Hoon Lee Sung Joon Lee Chang Don Kang Dae Hee Choi Jin Myung Park Seung-Joo Nam Tae Suk Kim Ji Hyun Kim Sung Chul Park Source Type: research
Recent clinical trials and optical control as a potential strategy to develop microtubule-targeting drugs in colorectal cancer management
World J Gastroenterol. 2024 Apr 7;30(13):1780-1790. doi: 10.3748/wjg.v30.i13.1780.ABSTRACTColorectal cancer (CRC) has remained the second and the third leading cause of cancer-related death worldwide and in the United States, respectively. Although significant improvement in overall survival has been achieved, death in adult populations under the age of 55 appears to have increased in the past decades. Although new classes of therapeutic strategies such as immunotherapy have emerged, their application is very limited in CRC so far. Microtubule (MT) inhibitors such as taxanes, are not generally successful in CRC. There may ...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Katsuhiro Kita Allen Burdowski Source Type: research
Exploring the impact of MiR-92a-3p on FOLFOX chemoresistance biomarker genes in colon cancer cell lines
Conclusion: We found that miR-92a-3p does not upregulate the expression of proteins of DNA-repair pathways and other genes involved in FOLFOX chemotherapy resistance.PMID:38659583 | PMC:PMC11039864 | DOI:10.3389/fphar.2024.1376638 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Paula I Escalante Luis A Qui ñones H éctor R Contreras Source Type: research
Gra-CRC-miRTar: The pre-trained nucleotide-to-graph neural networks to identify potential miRNA targets in colorectal cancer
bioRxiv [Preprint]. 2024 Apr 20:2024.04.15.589599. doi: 10.1101/2024.04.15.589599.ABSTRACTColorectal cancer (CRC) is the third most diagnosed cancer and the second deadliest cancer worldwide representing a major public health problem. In recent years, increasing evidence has shown that microRNA (miRNA) can control the expression of targeted human messenger RNA (mRNA) by reducing their abundance or translation, acting as oncogenes or tumor suppressors in various cancers, including CRC. Due to the significant up-regulation of oncogenic miRNAs in CRC, elucidating the underlying mechanism and identifying dysregulated miRNA tar...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Rui Yin Hongru Zhao Lu Li Qiang Yang Min Zeng Carl Yang Jiang Bian Mingyi Xie Source Type: research
Community Health workers United to Reduce Colorectal cancer and cardiovascular disease among people at Higher risk (CHURCH): study protocol for a randomized controlled trial
Discussion: Church-placed CHWs are trusted influential connectors between communities and health systems. Studies have shown that these CHWs can successfully implement health prevention protocols in churches, including those related to cancer control, making them potentially important community mediators of CRC screening uptake and CRC/CVD risk reduction. Trial registration: NCT05174286.PMID:38659874 | PMC:PMC11042434 | DOI:10.21203/rs.3.rs-3797889/v1 (Source: Cancer Control)
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Olajide Williams Tina Ting Lisa Matthews Gladys Block Torin Block Jeanne Teresi Joseph Eimicke Jian Kong Stephanie Silver Joseph Ravenell Janhavi Mallaiah Soujanya Jammalamadaka Laura Maudene Nelson Wahida Karmally Sidney Hankerson Source Type: research
Exploring the multifaceted bioactivities of < em > Lavandula pinnata L. < /em > essential oil: promising pharmacological activities
This study investigates the biological activities of Lavandula pinnata essential oil (LPEO), an endemic lavender species from the Canary Islands, traditionally used in treating various ailments. Methods: LPEO was extracted by hydrodistillation and analyzed using GC-MS. Antioxidant activity was assessed by DPPH radical scavenging and total antioxidant capacity assays. Antimicrobial activity was evaluated by disc diffusion, MIC, MBC, and MFC determination against bacterial (Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa) and fungal (Candida glabrata, Rhodotorula glutinis, Aspergillus nige...
Source: Cancer Control - April 25, 2024 Category: Cancer & Oncology Authors: Mounir Haddou Amine Elbouzidi Mohamed Taibi Abdellah Baraich El Hassania Loukili Reda Bellaouchi Ennouaamane Saalaoui Abdeslam Asehraou Ahmad Mohammad Salamatullah Mohammed Bourhia Hiba-Allah Nafidi Mohamed Addi Bouchra El Guerrouj Khalid Chaabane Source Type: research
α‐Hederin induces paraptosis by targeting GPCRs to activate Ca2+/MAPK signaling pathway in colorectal cancer
ConclusionsCollectively, our findings proved α-hed as a promising candidate for inducing non-apoptotic cell death, paraptosis. It may overcome the resistance of apoptotic-based chemo-resistance in CRC. (Source: Cancer Medicine)
Source: Cancer Medicine - April 25, 2024 Category: Cancer & Oncology Authors: Xiwu Rao,
Ziwen Li,
Qinchang Zhang,
Yueyang Lai,
Jianrong Liu,
Liu Li,
Haibo Cheng,
Weixing Shen,
Dongdong Sun Tags: RESEARCH ARTICLE Source Type: research
First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial
British Journal of Cancer, Published online: 25 April 2024; doi:10.1038/s41416-024-02696-6First-line oxaliplatin-based chemotherapy and nivolumab for metastatic microsatellite-stable colorectal cancer—the randomised METIMMOX trial (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Anne Hansen Ree J ūratė Šaltytė Benth Hanne M. Hamre Christian Kersten Eva Hofsli Marianne G. Guren Halfdan Sorbye Christin Johansen Anne Neg ård Tonje Bj ørnetrø Hilde L. Nilsen Jens P. Berg Kjersti Flatmark Sebastian Meltzer Source Type: research
CircCOL1A1 promotes proliferation, migration, and invasion of colorectal cancer (CRC) cells and glutamine metabolism through GLS1 up-regulation by sponging miR-214-3p
ConclusionThese findings suggest that circCOL1A1 functions as an oncogenic molecule to promote CRC progression via miR-214-3p/GLS1 axis, hinting on the potential of circCOL1A1 as a therapeutic target for CRC. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
