Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transformation
CONCLUSION: This study elucidates the potential molecular mechanisms underlying the occurrence of LM from various angles through single-cell multi-omics analysis in CRC. It also constructs a network illustrating the role of senescent or exhausted immune cells in regulating EMT.PMID:38683136 | DOI:10.18632/aging.205778 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Sen Lin Lanyue Ma Jiaxin Mo Ruiqi Zhao Jinghao Li Mengjiao Yu Mei Jiang Lisheng Peng Source Type: research
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis
CONCLUSIONS: Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.PMID:38680088 | DOI:10.1017/S0033291724000850 (Source: Psychological Medicine)
Source: Psychological Medicine - April 29, 2024 Category: Psychiatry Authors: Kuan-Yu Pan Lonneke van Tuijl Maartje Basten Judith J M Rijnhart Alexander de Graeff Joost Dekker Mirjam I Geerlings Adriaan Hoogendoorn Adelita V Ranchor Roel Vermeulen L ützen Portengen Adri C Voogd Jessica Abell Philip Awadalla Aartjan T F Beekman Ott Source Type: research
NestedBD: Bayesian inference of phylogenetic trees from single-cell copy number profiles under a birth-death model
Algorithms Mol Biol. 2024 Apr 29;19(1):18. doi: 10.1186/s13015-024-00264-4.ABSTRACTCopy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via "bulk sequencing," the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inf...
Source: Algorithms for Molecular Biology : AMB - April 29, 2024 Category: Molecular Biology Authors: Yushu Liu Mohammadamin Edrisi Zhi Yan Huw A Ogilvie Luay Nakhleh Source Type: research
NestedBD: Bayesian inference of phylogenetic trees from single-cell copy number profiles under a birth-death model
Algorithms Mol Biol. 2024 Apr 29;19(1):18. doi: 10.1186/s13015-024-00264-4.ABSTRACTCopy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via "bulk sequencing," the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inf...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Yushu Liu Mohammadamin Edrisi Zhi Yan Huw A Ogilvie Luay Nakhleh Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
CBX3 antagonizes IFN γ/STAT1/PD-L1 axis to modulate colon inflammation and CRC chemosensitivity
EMBO Mol Med. 2024 Apr 29. doi: 10.1038/s44321-024-00066-6. Online ahead of print.ABSTRACTAs an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis and colorectal cancer (CRC). Here, we demonstrated that the epigenetic regulator, CBX3 (also known as HP1γ) antagonizes IFNγ signaling in the colon epithelium by transcriptionally repressing two critical IFNγ-responsive genes: STAT1 and CD274 (encoding Programmed death-ligand 1, PD-L1). Accordingly, CBX3 deletion resulted in chronic mouse colon inflammation, accompanied by u...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Yao Xiang Jorge Mata-Garrido Yuanji Fu Christophe Desterke Eric Batsch é Ahmed Hama ï Christine Sedlik Youssouf Sereme David Skurnik Abdelali Jalil Rachel Onifarasoaniaina Eric Frapy Jean-Christophe Beche Razack Alao Eliane Piaggio Laurence Arbibe Yunhu Source Type: research
Comparative evaluation of hesperetin-loaded graphene oxide nanosheets (Hsp-GO) as a drug delivery system for colon cancer: synthesis and anticancer efficiency assessment
CONCLUSIONS: These study highlight the potential of Hsp-GO as a promising anti-cancer nano-drug for colon cancer therapy.PMID:38683228 | DOI:10.1007/s11033-024-09504-7 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - April 29, 2024 Category: Molecular Biology Authors: Arezou Sabbagh Hadi Mehdi Haghi Abolfazl Barzegar Mohammad Ali Hosseinpour Feizi Source Type: research
Retraction: MiR-34b inhibits the proliferation and promotes apoptosis in colon cancer cells by targeting Wnt/ β-catenin signaling pathway
Biosci Rep. 2024 May 29;44(5):BSR-2019-1799_RET. doi: 10.1042/BSR-2019-1799_RET.NO ABSTRACTPMID:38682477 | DOI:10.1042/BSR-2019-1799_RET (Source: Bioscience Reports)
Source: Bioscience Reports - April 29, 2024 Category: Biomedical Science Source Type: research
Preclinical evaluation of AGTR1-Targeting molecular probe for colorectal cancer imaging in orthotopic and liver metastasis mouse models
Eur J Med Chem. 2024 Apr 27;271:116452. doi: 10.1016/j.ejmech.2024.116452. Online ahead of print.ABSTRACTDespite advancements in colorectal cancer (CRC) treatment, the prognosis remains unfavorable for patients with distant liver metastasis. Fluorescence molecular imaging with specific probes is increasingly used to guide CRC surgical resection in real-time and treatment planning. Here, we demonstrate the targeted imaging capacity of an MPA-PEG4-N3-Ang II probe labeled with near-infrared (NIR) fluorescent dye targeting the angiotensin II (Ang II) type 1 receptor (AGTR1) that is significantly upregulated in CRC. MPA-PEG4-N3...
Source: European Journal of Medicinal Chemistry - April 29, 2024 Category: Chemistry Authors: Kuncheng Zhou Gang Li Rongbin Pan Sulin Xin Weijie Wen Huiyi Wang Chao Luo Ray P S Han Yueqing Gu Yuanbiao Tu Source Type: research
OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
CONCLUSION: We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway, and that this effect is mediated by the RIPK1-p62/SQSTM1 complex, in CRC cells. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.PMID:38681991 | PMC:PMC11045482 | DOI:10.3748/wjg.v30.i15.2155 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Source Type: research
< em > Fusobacterium nucleatum < /em > -induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer
CONCLUSION: F. nucleatum can promote cancer progression through its inhibitory effect on butyric acid, via the AMPK signaling pathway.PMID:38681125 | PMC:PMC11045493 | DOI:10.3748/wjg.v30.i14.2018 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou Xiang Li Source Type: research
Topic highlight on texture and color enhancement imaging in gastrointestinal diseases
In conclusion, TXI can improve gastrointestinal lesion detection and qualitative diagnosis. Therefore, further studies on the efficacy of TXI in clinical practice are required.PMID:38681121 | PMC:PMC11045492 | DOI:10.3748/wjg.v30.i14.1934 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 29, 2024 Category: Gastroenterology Authors: Osamu Toyoshima Toshihiro Nishizawa Keisuke Hata Source Type: research
Investigating the therapeutic potential of < em > Bifidobacterium breve < /em > and < em > Lactobacillus rhamnosus < /em > postbiotics through apoptosis induction in colorectal HT-29 cancer cells
CONCLUSION: Our research suggests that postbiotic metabolites may be effective biological products for the prevention and treatment of cancer.PMID:38682058 | PMC:PMC11055435 | DOI:10.18502/ijm.v16i1.14873 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nafiseh Erfanian Hossein Safarpour Tahmineh Tavakoli Mohammad Ali Mahdiabadi Saeed Nasseri Mohammad Hassan Namaei Source Type: research
Synergistic effects of < em > Bacillus coagulans < /em > and < em > Newcastle disease virus < /em > on human colorectal adenocarcinoma cell proliferation
CONCLUSION: It appears that utilizing oncolytic viruses (OV) and bacteria in conjunction with chemotherapy drugs could potentially aid in reducing the growth of colorectal cancer cells. However, further research is necessary, including animal studies, to confirm the efficacy of this treatment method.PMID:38682055 | PMC:PMC11055439 | DOI:10.18502/ijm.v16i1.14878 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hadi Esmaeili Gouvarchinghaleh Cyrus Jalili Maryam Zamir Nasta Fatemeh Mokhles Elmira Afrasiab Farhad Babaei Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
