Construction and validation of “WCH‐nomogram” for predicting the prognosis after resection of colorectal liver metastases
ConclusionsThe WCH-nomogram demonstrates superior prognostic stratification compared to prior scoring systems, effectively identifying CRLM patients who may benefit the most from neoadjuvant chemotherapy. (Source: Cancer Medicine)
Source: Cancer Medicine - May 3, 2024 Category: Cancer & Oncology Authors: Chuang Jiang,
Weixing Liu,
Zechuan Jin,
Ling Lan,
Lin Xu,
Ao Du,
Song Peng,
Yong Zeng,
Haichuan Wang,
Mingheng Liao,
Jin Zhou Tags: RESEARCH ARTICLE Source Type: research
Missingness mechanisms and generalizability of patient reported outcome measures in colorectal cancer survivors – assessing the reasonableness of the “missing completely at random” assumption
This study aims ... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - May 3, 2024 Category: Research Authors: Johanne Dam Lyhne, Allan ‘Ben’ Smith, Lars Henrik Jensen, Torben Frøstrup Hansen, Lisbeth Frostholm and Signe Timm Tags: Research Source Type: research
Fertility drugs and cancer: a guideline
Methodological limitations in studying the association between the use of fertility drugs and cancer include the inherent increased risk of cancer in women who never conceive, the increased risk of cancer because of factors (endometriosis and unopposed estrogen) associated with infertility, the low incidence of most of these cancers, and that the diagnosis of cancer is typically several years after fertility drug use. On the basis of available data, there does not appear to be an association between fertility drugs and breast, colon, or cervical cancer. (Source: Fertility and Sterility)
Source: Fertility and Sterility - May 3, 2024 Category: Reproduction Medicine Authors: Practice Committee of the American Society for Reproductive Medicine Tags: ASRM pages Source Type: research
Adherence to follow-up and resource use after abnormal FIT-screening: Evaluation of the Danish colorectal cancer screening program
Conclusions High adherence to baseline colonoscopy after positive FIT-screening is followed by lower adherence throughout the adenoma surveillance program. Better adherence to the guidelines could potentially improve the effectiveness and efficiency of the screening program. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - May 3, 2024 Category: Gastroenterology Authors: J ørgensen, Susanne Fogh Larsen, Pernille Thordal Erichsen, Rune Andersen, Berit Rebolj, Matejka Njor, Sisse Tags: Original article Source Type: research
Long-term survival after hepatic resection for colorectal liver metastases: a single-center study in Iran
Surgical resection of colorectal cancer liver metastasis (CRLM) has been associated with improved survival in these patients. The purpose of this study was to investigate the usefulness of liver metastasectomy... (Source: BMC Surgery)
Source: BMC Surgery - May 3, 2024 Category: Surgery Authors: Seyed Morteza Pourfaraji, Mehdi Nazari Moghadam, Ali Mohammad Moradi, Fatemeh Ojaghi Shirmard, Narjes Mohammadzadeh and Ali Jafarian Tags: Research Source Type: research
Molecules, Vol. 29, Pages 2119: Verification of In Vitro Anticancer Activity and Bioactive Compounds in Cordyceps Militaris-Infused Sweet Potato Shochu Spirits
This study aims to verify in vitro anticancer activity and bioactive compounds in shochu spirits infused with Cordyceps militaris, a Chinese medicine. The results revealed that a bioactive fraction was eluted from the spirit extract with 40% ethanol. The infusion time impacted the inhibitory effect of the spirit extract on the proliferation of colon cancer-derived cell line HCT-116 cells, and a 21-day infusion showed the strongest inhibitory effect. Furthermore, the spirit extract was separated into four fractions, A-D, by high-performance liquid chromatography (HPLC), and Fractions B, C, and D, but not A, exerted the effe...
Source: Molecules - May 3, 2024 Category: Chemistry Authors: Kozue Sakao Cho Sho Takeshi Miyata Kensaku Takara Rio Oda De-Xing Hou Tags: Article Source Type: research
Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
This study aimed to evaluate the significance of homocysteine (HCY) levels in predicting recurrence-free survival (RFS) and overall survival (OS) in colorectal cancer (CRC) patients. This retrospective study involved 1272 CRC patients. The risk of mortality increased with increasing HCY levels in CRC patients. The optimal HCY cutoff value in CRC patients was 15.2 μmol/L. The RFS (45.8% vs. 60.5%, p < 0.001) and OS (48.2% vs. 63.2%, p < 0.001) of patients with high HCY levels were significantly lower than those of patients with low HCY levels. Patients with high HCY levels were older, male, had large tumours, high ca...
Source: Anal Sci - May 2, 2024 Category: Chemistry Authors: Hailun Xie Lishuang Wei Qiwen Wang Shuangyi Tang Jialiang Gan Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
C-C Chemokine 21-Expressing T-cell Zone Fibroblastic Reticular Cells, Abundant in Lymph Nodes, Are Absent in Cancer Lymphoid Stroma
Acta Histochem Cytochem. 2024 Apr 25;57(2):67-74. doi: 10.1267/ahc.23-00066. Epub 2024 Apr 4.ABSTRACTCancer tissue generally possesses an immunosuppressive microenvironment. However, some cancers are associated with lymphoid stroma (i.e., a widely developed tertiary lymphoid structure). The T-cell zone (paracortex) of secondary lymphoid organs, particularly lymph nodes, is characterized by an abundance of T-cell zone fibroblastic reticular cells (TCZ-FRCs) that express C-C motif chemokine ligand 21 (CCL21) and smooth muscle actin (SMA). We analyzed the presence of TCZ-FRCs in 30 cases of carcinomas with lymphoid stroma of ...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Haruo Ohtani Kazuhiko Matsuo Kosuke Kitahata Eiichi Sato Takashi Nakayama Source Type: research
Evaluating complete response prediction rates in locally advanced rectal cancer with different radiomics segmentation approaches
CONCLUSION: Although the highest AUC result is obtained from the tumor segmentation, the highest accuracy and sensitivity are detected with tumor+mesorectum segmentation and these findings align with previous studies, suggesting that the mesorectum contains valuable insights for CR. The lowest result is obtained with CTV segmentation. More studies with mesorectum and pelvic nodal regions included in segmentation are needed.PMID:38694706 | PMC:PMC11061551 | DOI:10.3389/pore.2024.1611744 (Source: Pathology Oncology Research)
Source: Pathology Oncology Research - May 2, 2024 Category: Pathology Authors: Gizem Kaval Merve Gulbiz Dagoglu Kartal Sena Azamat Eda Cingoz Gokhan Ertas Sule Karaman Basak Kurtuldu Metin Keskin Neslihan Berker Senem Karabulut Ethem Nezih Oral Nergiz Dagoglu Sakin Source Type: research
Prostaglandin E2 in the Tumor Microenvironment, a Convoluted Affair Mediated by EP Receptors 2 and 4
Pharmacol Rev. 2024 May 2;76(3):388-413. doi: 10.1124/pharmrev.123.000901.ABSTRACTThe involvement of the prostaglandin E2 (PGE2) system in cancer progression has long been recognized. PGE2 functions as an autocrine and paracrine signaling molecule with pleiotropic effects in the human body. High levels of intratumoral PGE2 and overexpression of the key metabolic enzymes of PGE2 have been observed and suggested to contribute to tumor progression. This has been claimed for different types of solid tumors, including, but not limited to, lung, breast, and colon cancer. PGE2 has direct effects on tumor cells and angiogenesis th...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Ana Santiso Akos Heinemann Julia Kargl Source Type: research
Clinico-pathological evaluation of tumor budding in the oncological progression of colorectal cancer
CONCLUSION: These results suggest that TB expression may be a useful risk factor as a prognostic factor for the detection of lymph node metastasis, local recurrence, and distant metastasis in CRC.PMID:38697893 | DOI:10.1016/j.medcli.2024.02.017 (Source: Medicina Clinica)
Source: Medicina Clinica - May 2, 2024 Category: General Medicine Authors: Pietro Giovanni Giordano Ana Gabriela D íaz Zelaya Yari Yuritzi Aguilera Molina Nestor Orlando Taboada Mostajo Yelene Ajete Ramos Ricardo Ortega Garc ía Esteban Peralta de Michelis Juan Carlos Meneu D íaz Source Type: research
Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment
CONCLUSION: In this cohort of oligometastatic CRC, detection of ctDNA pre- or post-procedure was associated with inferior outcomes even after accounting for prognostic clinicopathologic variables. This suggests ctDNA may enhance current risk stratification methods helping evaluate novel treatments and surveillance strategies toward improving patient outcomes.PMID:38695832 | DOI:10.1158/1078-0432.CCR-23-3660 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 2, 2024 Category: Cancer & Oncology Authors: Aparna R Parikh Bryant H Chee Jill Tsai Thereasa A Rich Kristin S Price Sonia A Patel Li Zhang Faaiz Ibrahim Mikaela Esquivel Emily E Van Seventer Joy X Jarnagin Victoria M Raymond Carlos U Corvera Kenzo Hirose Eric K Nakakura Ryan B Corcoran Katherine Va Source Type: research
A Randomized Trial of Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting
CONCLUSION: Both choice of testing and FIT alone increased response and may align with patient preferences.PMID:38697235 | DOI:10.1016/j.cgh.2024.04.003 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 2, 2024 Category: Cancer & Oncology Authors: Shivan J Mehta Sanjay Palat Caitlin McDonald Catherine Reitz Evelyn Okorie Keyirah Williams Jinming Tao Pamela A Shaw Karen Glanz David A Asch Source Type: research
Clinico-pathological evaluation of tumor budding in the oncological progression of colorectal cancer
CONCLUSION: These results suggest that TB expression may be a useful risk factor as a prognostic factor for the detection of lymph node metastasis, local recurrence, and distant metastasis in CRC.PMID:38697893 | DOI:10.1016/j.medcli.2024.02.017 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 2, 2024 Category: Cancer & Oncology Authors: Pietro Giovanni Giordano Ana Gabriela D íaz Zelaya Yari Yuritzi Aguilera Molina Nestor Orlando Taboada Mostajo Yelene Ajete Ramos Ricardo Ortega Garc ía Esteban Peralta de Michelis Juan Carlos Meneu D íaz Source Type: research
