Sequencing considerations in the third-line treatment of metastatic colorectal cancer
Am J Manag Care. 2024 May;30(2 Suppl):S31-S35. doi: 10.37765/ajmc.2024.89546.ABSTRACTNumerous advances in the standard of care for metastatic colorectal cancer (mCRC), including the approval of several new treatments indicated for treatment in the third line or later (3L+), have been made, yet data and appropriate guidance on the optimal sequencing and treatment strategies for these lines of therapy are lacking. Four treatments-regorafenib, trifluridine/tipiracil alone or with bevacizumab, and fruquintinib-are FDA-approved and recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for the trea...
Source: The American Journal of Managed Care - May 3, 2024 Category: Health Management Authors: Afsaneh Barzi Tanios Bekaii-Saab Source Type: research
Radiosensitizing effects of heparinized magnetic iron oxide nanoparticles in colon cancer
Biomed Pharmacother. 2024 May 2;175:116668. doi: 10.1016/j.biopha.2024.116668. Online ahead of print.ABSTRACTThe combination of radiation treatment and chemotherapy is currently the standard for management of cancer patients. However, safe doses do not often provide effective therapy, then pre-treated patients are forced to repeat treatment with often already increased tumor resistance to drugs and irradiation. One of the solutions we suggest is to improve primary course of radiation treatment via enhancing radiosensitivity of tumors by magnetic-guided iron oxide nanoparticles (magnetite). We obtained spherical heparinized...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 3, 2024 Category: Drugs & Pharmacology Authors: Maria V Shestovskaya Anna L Luss Olga A Bezborodova Pavel P Kulikov Daria A Antufrieva Ekaterina A Plotnikova Valentin V Makarov Vladimir S Yudin Andrey A Pankratov Anton A Keskinov Source Type: research
Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)
Acta Oncol. 2024 May 2;63:248-258. doi: 10.2340/1651-226X.2024.24023.ABSTRACTBACKGROUND AND PURPOSE: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative fluoropyrimidine (FP). In light of the European Medicines Agency approval of S-1 in metastatic colorectal cancer (mCRC), this analysis provides more detailed safety and efficacy information, and data regarding metastasectomy and/or local ablative therapy (LAT), on the mCRC patients from the original study.MATERIALS AND METHODS: This re...
Source: Acta Oncologica - May 3, 2024 Category: Cancer & Oncology Authors: Sampsa Kinos Helga Hagman P äivi Halonen Leena-Maija Soveri Mary O'Reilly Per Pfeiffer Jan-Erik Fr ödin Halfdan Sorbye Eetu Heerv ä Gabor Liposits Raija Kallio Annika Ålgars Raija Ristam äki Tapio Salminen Maarit B ärlund Carl-Henrik Shah Ray McDerm Source Type: research
Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network
CONCLUSIONS: A highly accurate CNN matched the performance of colorectal surgeons in identifying a noncomplete response to TNT. However, the model demonstrated suboptimal accuracy when analyzing images of local regrowth.PMID:38700799 | DOI:10.1245/s10434-024-15311-y (Source: Ann Oncol)
Source: Ann Oncol - May 3, 2024 Category: Cancer & Oncology Authors: Hannah Williams Hannah M Thompson Christina Lee Aneesh Rangnekar Jorge T Gomez Maria Widmar Iris H Wei Emmanouil P Pappou Garrett M Nash Martin R Weiser Philip B Paty J Joshua Smith Harini Veeraraghavan Julio Garcia-Aguilar Source Type: research
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Clinical Application of Self-Expanding Metal Stents in the Treatment of Obstructive Colorectal Cancer
CONCLUSION: These findings suggest that stent placement is safe and effective, but there is a risk of complications that should be considered. It can serve as a transitional treatment or relieve symptoms in advanced cancer and improve quality of life.PMID:38702171 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 3, 2024 Category: Complementary Medicine Authors: Kuangjing Wang Haitao Wang Yingzhou Shen Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Curcumin and its anti-colorectal cancer potential: From mechanisms of action to autophagy
Phytother Res. 2024 May 3. doi: 10.1002/ptr.8220. Online ahead of print.ABSTRACTColorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, a...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Aranka Brockmueller Vicen ç Ruiz de Porras Mehdi Shakibaei Source Type: research
Yogurt Prevents Colorectal Tumorigenesis in Apc < sup > Min/+ < /sup > Mice
CONCLUSION: Yogurt protects against intestinal polyposis in ApcMin/+ mice, and d-Lac may partially account for the chemopreventive effects above.PMID:38700077 | DOI:10.1002/mnfr.202300737 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiaojing Li Jin Qian Qinglong Liu Min Guo Hao Zhang Haitao Li Wei Chen Source Type: research
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
CONCLUSION: TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.PMID:38699653 | PMC:PMC11063473 | DOI:10.2147/CMAR.S447549 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ahmet Bozdag Tuncay Kuloglu Gokhan Artas Suleyman Aydin Source Type: research
Exploring microRNA patterns as biomarkers of FOLFOX chemotherapy-induced peripheral neuropathy in patients with colorectal cancer
This study aimed to evaluate circulating miRNA, cortisol and catecholamine as potential biomarkers that can predict FOLFOX-CIPN symptoms. High-throughput microRNA (miRNA) sequencing was performed on the RNA circulating in the plasma of eight patients with CRC who underwent FOLFOX chemotherapy. miRNA expression profiles were evaluated according to two groups: those who underwent ≤3 cycles and those who underwent ≥6 cycles of FOLFOX chemotherapy. The identified miRNAs were validated in 27 patients with CRC who underwent FOLFOX chemotherapy using quantitative reverse transcription polymerase chain reaction. Target genes w...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Yeongdon Ju Dong Hoon Baek Go-Eun Choi Aelee Jang Source Type: research
Macromolecules with predominant β-pleated sheet proteins in extracellular vesicles released from Raphanus sativus L. var. caudatus Alef microgreens induce DNA damage-mediated apoptosis in HCT116 colon cancer cells
Int J Biol Macromol. 2024 May 1:132001. doi: 10.1016/j.ijbiomac.2024.132001. Online ahead of print.ABSTRACTPlant-derived bioactive macromolecules (i.e., proteins, lipids, and nucleic acids) were prepared as extracellular vesicles (EVs). Plant-derived EVs are gaining pharmaceutical research interest because of their bioactive components and delivery properties. The spherical nanosized EVs derived from Raphanus sativus L. var. caudatus Alef microgreens previously showed antiproliferative activity in HCT116 colon cancer cells from macromolecular compositions (predominantly proteins). To understand the mechanism of action, the...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Karnchanok Kaimuangpak Reny Rosalina Kanjana Thumanu Natthida Weerapreeyakul Source Type: research
Structural and functional characteristics of pectins from three cultivars of apple (Malus pumila Mill.) pomaces
This study aimed to investigate the chemical composition, structural properties, and biological properties of pectin polysaccharides (AP-FS, AP-QG, and AP-HG) isolated from different varieties of apple pomace. Based on the methylation and nuclear magnetic resonance analyses, the structure of AP-FS was determined to be composed of an α-1,4-linked homogalacturonan backbone that exhibited high levels of O-6 methylation. All pectins exhibit potent inhibitory activity against human colon cancer and human liver cancer cells, along with immunostimulatory effects. Among them, AP-FS exhibited the highest activity level. Finally, w...
Source: International Journal of Biological Macromolecules - May 3, 2024 Category: Biochemistry Authors: Huan Guo Hang Li Wenyi Ran Wenyue Yu Yue Xiao Renyou Gan Hong Gao Source Type: research
