The effect of proton pump inhibitors on survival outcomes in advanced hepatocellular carcinoma treated with sorafenib.
CONCLUSION: In a large high-quality dataset, PPI use was not observed to compromise the survival outcomes of advanced HCC patients initiated on sorafenib. PMID: 32449002 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Ruanglertboon W, Sorich MJ, Logan JM, Rowland A, Hopkins AM Tags: J Cancer Res Clin Oncol Source Type: research

Epidemiology of Brain Metastases.
Abstract Brain metastasis continues to be a devastating complication of systemic malignancy, affecting approximately 20% of all patients suffering from cancer. Despite being a major source of morbidity and mortality for this patient population, a nationwide, systematic mechanism for reporting of brain metastases does not exist. Better understanding the epidemiology of brain metastases will help identify individuals who are at greatest risk of developing them and guide clinicians in selecting patients who are most likely to benefit from brain metastasis surveillance and prophylaxis. PMID: 32921345 [PubMed - in...
Source: Clinical Genitourinary Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Sacks P, Rahman M Tags: Neurosurg Clin N Am Source Type: research

Pathological Features of Brain Metastases.
Abstract Metastases are the most common intracranial tumors in adults. Lung cancer, melanoma, renal cell carcinoma, and breast cancer are the most common primary tumors that metastasize to the brain. Improved detection of small metastases by MRI, and improved systemic therapy for primary tumors, resulted in increased incidence of brain metastasis. Advances in neuroanesthesia and neurosurgery have significantly improved the safety of surgical resection of brain metastases. Surgical approach and active management have become applicable for many patients. Subsequently, brain metastases diagnosis no longer equals pall...
Source: Clinical Genitourinary Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Tadros S, Ray-Chaudhury A Tags: Neurosurg Clin N Am Source Type: research

Personalizing vulvar cancer workflow in COVID-19 era: a proposal from Vul.Can MDT.
CONCLUSION: We suggest that our proposals are applicable in this setting of patients, considering anyway current international recommendations and guidelines. PMID: 32656663 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 12, 2020 Category: Cancer & Oncology Authors: Garganese G, Tagliaferri L, Fragomeni SM, Lancellotta V, Colloca G, Corrado G, Gentileschi S, Macchia G, Tamburrini E, Gambacorta MA, Fagotti A, Scambia G, Gemelli Vul.Can MDT Tags: J Cancer Res Clin Oncol Source Type: research

Unique Techniques or  Approaches in Microvascular and Microlymphatic Surgery.
Unique Techniques or Approaches in Microvascular and Microlymphatic Surgery. Clin Plast Surg. 2020 Oct;47(4):649-661 Authors: Tang JB, Landín L, Cavadas PC, Thione A, Chen J, Pons G, Masià J Abstract Several methods can be used for identifying tissues for transfer in donor-site-depleted patients. A fillet flap can be temporarily stored in other parts of the body and transferred back to the site of tissue defect, including covering the amputated stump of the lower extremity. Human arm transplant is rare and has some unique concerns for the surgery and postsurgical treatment. Cosmetic...
Source: Clinical Genitourinary Cancer - September 9, 2020 Category: Cancer & Oncology Authors: Tang JB, Landín L, Cavadas PC, Thione A, Chen J, Pons G, Masià J Tags: Clin Plast Surg Source Type: research

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population.
Conclusions: Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation. PMID: 32765800 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Białkowska K, Marciniak W, Muszyńska M, Baszuk P, Gupta S, Jaworska-Bieniek K, Sukiennicki G, Durda K, Gromowski T, Lener M, Prajzendanc K, Łukomska A, Cybulski C, Huzarski T, Gronwald J, Dębniak T, Lubiński J, Jakubowska A Tags: Hered Cancer Clin Pract Source Type: research

CLDN6-mediates SB431542 action through MMPs to regulate the invasion, migration, and EMT of breast cancer cells.
Abstract Our previous research confirmed the repression of SMADs signaling pathway inhibits the invasion, migration, and EMT in breast cancer MCF-7 and SKBR-3 cell lines by DNMT1 up-regulating CLDN6, but the mechanism is unclear. Western blot was performed to detect the expression of SMAD2, SMAD3, P-SMAD2, and P-SMAD3. Then RT-PCR was carried out to examine the expression of tight junctions and cell adhesion molecule E-cadherin. According to the gene sequence of Claudin6, shRNA was linked with the green fluorescent protein-expressing eukaryotic expression vector pGC silencer TMΜ6/Neo/GFP, and it was transfected...
Source: Clinical Genitourinary Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Li X, Li H, Liu C, Leng X, Liu T, Zhang X, Bai Q, Wang L Tags: Int J Clin Exp Pathol Source Type: research

Retroperitoneal metastasis synchronous with brain and mediastinal lymph nodes metastasis from breast invasive ductal carcinoma as the first site of distant metastasis: a case report and review of literature.
We reported a case of a 52 year old Chinese patient who was diagnosed with retroperitoneal metastasis from breast invasive ductal carcinoma as the first site of distant metastasis synchronous with brain and mediastinal lymph nodes metastasis 4 years after modified radical mastectomy. Second-line chemotherapy of docetaxel and capecitabine was recommended. The response evaluation every two to three months was good. Unfortunately, the metastasis in the brain advanced. The patient was transferred to a radiotherapy department to receive radiotherapy and died 10 months later. We also review the related literature. PMID: 327...
Source: Clinical Genitourinary Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Chen ML, Ma ZS, Cao FL, Yan XQ, Zhang LM, Wang XB, Xie BJ Tags: Int J Clin Exp Pathol Source Type: research

Clinical and molecular characteristics of secondary breast metastases from primary lung cancer: a study of 22 Chinese cases.
CONCLUSION: A lung cancer patient with a breast tumor should suggest the possibility of metastasis. It is extremely difficult to distinguish secondary breast cancer from primary simply through medical observation and pathologic testing. Additional immunohistochemical examinations are necessary to avoid delays in diagnosis and treatment. PMID: 32782718 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 13, 2020 Category: Cancer & Oncology Authors: Zhu Y, Liu WW, Wu Q, Yao JH, Zhou ZG, Yang Y Tags: Int J Clin Exp Pathol Source Type: research

Corrigendum to: Venous thromboembolism in cancer patients: report of baseline data from the multicentre, prospective Cancer-VTE Registry.
PMID: 32778867 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2020 Category: Cancer & Oncology Authors: Ohashi Y, Ikeda M, Kunitoh H, Sasako M, Okusaka T, Mukai H, Fujiwara K, Nakamura M, Oba MS, Kimura T, Ibusuki K, Sakon M Tags: Jpn J Clin Oncol Source Type: research

Hypofractionated Versus Conventional Fractionated Radiotherapy After Breast-Conserving Surgery in the Modern Treatment Era: A Multicenter, Randomized Controlled Trial From China.
CONCLUSION: CFRT and HFRT with a tumor-bed boost may have similar low LR and toxicity. PMID: 32780661 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2020 Category: Cancer & Oncology Authors: Wang SL, Fang H, Hu C, Song YW, Wang WH, Jin J, Liu YP, Ren H, Liu J, Li GF, Du XH, Tang Y, Jing H, Ma YC, Huang Z, Chen B, Tang Y, Li N, Lu NN, Qi SN, Yang Y, Sun GY, Liu XF, Li YX Tags: J Clin Oncol Source Type: research

Neoplasia in Turner syndrome: a retrospective cohort study in a tertiary referral centre in Belgium.
CONCLUSION: The overall malignancy risk was not increased, but a different pattern of occurrence is apparent, with an increased risk of CNS and skin tumours and a decreased breast cancer risk. Gonadoblastoma/dysgerminoma was not reported. There is a need for centralised multidisciplinary care and prospective research to unravel and predict the neoplasia risk. PMID: 32780684 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2020 Category: Cancer & Oncology Authors: Dejonckheere C, Moyson C, de Zegher F, Antonio L, Van Buggenhout G, Decallonne B Tags: Acta Clin Belg Source Type: research

The IL1 β-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs).
CONCLUSIONS: Our data shed new light on the role of hypoxia in the activation of the IL-1β/IL1R1 signaling, which in turn triggers aggressive features in both TNBC cells and CAFs. Hence, our findings provide novel evidence regarding the mechanisms through which the hypoxic tumor microenvironment may contribute to breast cancer progression and suggest further targets useful in more comprehensive therapeutic strategies. PMID: 32778144 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Lappano R, Talia M, Cirillo F, Rigiracciolo DC, Scordamaglia D, Guzzi R, Miglietta AM, De Francesco EM, Belfiore A, Sims AH, Maggiolini M Tags: J Exp Clin Cancer Res Source Type: research

Real-world impact of anti-HER2 therapy-related cardiotoxicity in patients with advanced HER2-positive breast cancer.
CONCLUSION: Therapy-related cardiotoxicity is an uncommon complication of anti-HER2 therapy in the real world setting. Cardiac toxicity resolved in the majority of affected patients, and further anti-HER2 therapy was administered without recurrence of cardiac issues. Our data suggests anti-HER2 therapy can be safely given in routine care, even in patients with risk factors for toxicity. PMID: 32779390 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Conduit C, de Boer RH, Lok S, Gibbs P, Malik L, Loh Z, Yeo B, Greenberg S, Devitt B, Lombard J, Nottage M, Collins I, Torres J, Nolan M, Nott L Tags: Asia Pac J Clin Oncol Source Type: research

Identifying ultrasound features of positive expression of Ki67 and P53 in breast cancer using radiomics.
CONCLUSIONS: Our study revealed that breast cancer ultrasonic findings were closely related to expression of molecular indicators, suggesting that ultrasound can be used to provide useful information to clinicians. PMID: 32779399 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Cui H, Zhang D, Peng F, Kong H, Guo Q, Wu T, Wen X, Zhang L, Tian J Tags: Asia Pac J Clin Oncol Source Type: research

Development and validation of a metabolic gene signature for predicting overall survival in patients with colon cancer.
This study aimed to identify a metabolic gene signature to categorize colon cancer patients into high- and low-risk groups and predict prognosis. Samples from the Gene Expression Omnibus database were used as the training cohort, while samples from The Cancer Genome Atlas database were used as the validation cohort. A metabolic gene signature was established to investigate a robust risk stratification for colon cancer. Subsequently, a prognostic nomogram was established combining the metabolism-related risk score and clinicopathological characteristics of patients. A total of 351 differentially expressed metabolism-related...
Source: Clinical Genitourinary Cancer - August 8, 2020 Category: Cancer & Oncology Authors: Ren J, Feng J, Song W, Wang C, Ge Y, Fu T Tags: Clin Exp Med Source Type: research

Prevalence and associated factors of perceived cancer-related stigma in Japanese cancer survivors.
This study aimed to examine the prevalence and associated factors of perceived cancer-related stigma among Japanese cancer survivors. In this web-based survey involving 628 Japanese cancer survivors, perceived cancer-related stigma, quality of life (Quality of Life-Cancer Survivors Instrument), psychological distress (K6) and perceived social support (multidimensional scale of perceived social support) were evaluated. Perceived cancer-related stigma was endorsed by 61.2% of the participants. Perceived cancer-related stigma was significantly associated with quality of life (R = 0.35-0.37), psychological distress (...
Source: Clinical Genitourinary Cancer - August 8, 2020 Category: Cancer & Oncology Authors: Fujisawa D, Umezawa S, Fujimori M, Miyashita M Tags: Jpn J Clin Oncol Source Type: research

Development of the Breast Cancer Related Lymphedema Self-Care Scale.
uml;r S Abstract The purpose of study was to develop the Breast Cancer Related Lymphedema Self-Care Scale to evaluate the self-care practices of women with breast cancer-related lymphedema (BRCL); and to examine the psycholinguistic and psychometric characteristics of this scale. The item pool of the scale was created based on the literature in this descriptive study. Content validity, explanatory and confirmatory factor analyses used in evaluation of the validity; and item analyzes, the Cronbach's Alpha and Split Half analyzes were made for reliability in the study. The content validity index was found to be abov...
Source: Clinical Genitourinary Cancer - August 6, 2020 Category: Cancer & Oncology Authors: Deveci Z, Karayurt Ö, Bilik O, Eyigör S Tags: Clin Nurs Res Source Type: research

Discrimination of ascitic fluid infection in malignant ascites by polymorphonuclear neutrophil ratio and count: Investigating the validity of count ≥250/mm3 as the one-size-fits-all criterion.
CONCLUSIONS: Both polymorphonuclear neutrophil ratio and count had good discriminative abilities for culture results in MA. Polymorphonuclear neutrophil ratio was somewhat better despite lacking statistical significance compared to polymorphonuclear neutrophil count, with 70% as best cutoff. PMID: 32762145 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 6, 2020 Category: Cancer & Oncology Authors: Moon H, Kim HJ, Woo SM, Park IH, Sim SH Tags: Asia Pac J Clin Oncol Source Type: research

Regulatory CDH4 genetic variants associate with risk to develop capecitabine-induced hand-foot syndrome.
-Moreno M, Benítez J, González-Neira A Abstract Capecitabine-Induced Hand-Foot Syndrome (CiHFS) is a common dermatological adverse reaction affecting around 30% of capecitabine-treated cancer patients, and the main cause of dose reductions and chemotherapy delays. To identify novel genetic factors associated with CiHFS in cancer patients, we carried out an extreme-phenotype genome-wide association study (GWAS) in 166 breast and colorectal capecitabine-treated cancer patients with replication in a second cohort of 85 patients. We discovered and replicated a cluster of four highly correlated SNPs assoc...
Source: Clinical Genitourinary Cancer - August 5, 2020 Category: Cancer & Oncology Authors: Ruiz-Pinto S, Pita G, Martín M, Nunez-Torres R, Cuadrado A, Shahbazi MN, Caronia D, Kojic A, Moreno LT, de JC, la Torre-Montero, Lozano M, López-Fernández LA, Ribelles N, García-Saenz JA, Alba E, Milne RL, Losada A, Pérez-Moreno M, Benítez J, Gonzá Tags: Clin Pharmacol Ther Source Type: research

Association of HLA-G 3'UTR 14-bp Ins/Del polymorphism with breast cancer among South Indian women.
CONCLUSION: The findings of the present study suggest that the HLA-G 14-bp Ins/Del polymorphism could influence breast cancer pathogenesis among South Indian women. PMID: 31796638 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 1, 2020 Category: Cancer & Oncology Authors: Kadiam S, Ramasamy T, Ramakrishnan R, Mariakuttikan J Tags: J Clin Pathol Source Type: research

Surgical outcomes of second primary lung cancer after the extrapulmonary malignancy.
CONCLUSIONS: Second primary lung cancers following extrapulmonary malignancies were not uncommon. Surgical resection is considered for early stage secondary primary lung cancer after meticulous work up and result in fair outcome. PMID: 32632580 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Ko KH, Huang HK, Chen YI, Chang H, Tsai WC, Huang TW Tags: J Cancer Res Clin Oncol Source Type: research

Impact of the extent of axillary surgery in patients with N2-3 disease in the de-escalation era: a propensity score-matched study.
CONCLUSION: Additional level-III dissection has a limited impact on survival but still valuable in an accurate stage. The reduction of surgeries in axillary should be treated with discretion in breast cancer patients with a heavy axillary burden. PMID: 32632654 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Kong Y, Yang A, Xie X, Zhang J, Xu H, Li M, Lyu N, Wei W Tags: Clin Transl Oncol Source Type: research

Dosimetric benefits of gantry-static couch-motion (GsCM) technique for breast boost radiation therapy: Reduced dose to organs-at-risk and improved dosimetric indices.
Abstract To evaluate the clinical feasibility and dosimetric benefits of a novel gantry-static couch-motion (GsCM) technique for external beam photon boost treatment of lumpectomy cavity in patients with early-stage breast cancer in comparison to three-dimensional conformal radiotherapy (3D-CRT), wedge pair in supine position (WPS), and wedge pair in decubitus position (WPD) techniques. A retrospective review was conducted on breast patients (right breast, n = 10 and left breast, n = 10) who received 10 Gy boost after 50 Gy to whole breast. The treatment plans were generated using an ...
Source: Clinical Genitourinary Cancer - July 5, 2020 Category: Cancer & Oncology Authors: Gill GS, Jakubovic RY, Baker J, Button T, Chang J Tags: J Appl Clin Med Phys Source Type: research

A multidisciplinary consensus on the morphological and functional responses to immunotherapy treatment.
In this report, a group of experts of the Spanish Society of Medical Oncology (SEOM), the Spanish Society of Medical Radiology (SERAM), and Spanish Society of Nuclear Medicine and Molecular Imaging (SEMNIM) provide an up-to-date review and a consensus guide on these issues. PMID: 32623581 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 4, 2020 Category: Cancer & Oncology Authors: Leon-Mateos L, Garcia-Velloso MJ, García-Figueiras R, Rodriguez-Moreno JF, Vercher-Conejero JL, Sánchez M, Perez Gracia JL, Simo-Perdigo M, Gorospe L Tags: Clin Transl Oncol Source Type: research

Evaluation of Pectoral Nerve Block in Modified Radical Mastectomy: Comparison of Three Concentrations of Ropivacaine.
Abstract Background: Pectoral nerve block type I (PECS I Block) and type II (PECS II Block) with ropivacaine are relatively new analgesic methods for breast-cancer surgery. We evaluated the safety and efficacy of different concentrations of ropivacaine given in the same volume for the PECS II Block in patients undergoing modified radical mastectomy (MRM). Patients and Methods: One hundred and twenty women undergoing elective MRM who met inclusion criteria were divided randomly into four groups of 30: control group without PECS II Block and R0.2%, R0.3%, and R0.4% groups, who received general anesthesia plus t...
Source: Clinical Genitourinary Cancer - July 3, 2020 Category: Cancer & Oncology Authors: Deng W, Fu D, He L Tags: Clin Interv Aging Source Type: research

Technical Validity of a Customized Assay of Sensitivity to Endocrine Therapy Using Sections from Fixed Breast Cancer Tissue.
CONCLUSIONS: Measurement of the novel SET2,3 assay was technically valid from fixed tumor sections of biopsy or resection samples using simple, inexpensive, hybridization methods, without the need for RNA purification. PMID: 32613237 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lau R, Du L, Chen E, Fu C, Gould R, Marczyk M, Sinn BV, Layman R, Bedrosian I, Valero V, Symmans WF Tags: Clin Chem Source Type: research

A dosimetry study of post-mastectomy radiation therapy with AeroForm tissue expander.
CONCLUSIONS: The AeroForm creates significant dose uncertainties in the chest wall-metal interface. The AcurosXB dose calculation algorithm is recommended for more accurate calculations. If possible, post-mastectomy radiation therapy should be delivered after the permanent implant is in place. PMID: 32614518 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Lim SB, Kuo LC, Li G, Kuo HC, McCormick B, Cahlon O, Powell S, Hong LX Tags: J Appl Clin Med Phys Source Type: research

Dietary Moderation and Deaths From Breast Cancer.
PMID: 32614701 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Chlebowski RT, Aragaki AK, Prentice RL Tags: J Clin Oncol Source Type: research

Differential Benefit of Adjuvant Docetaxel-Based Chemotherapy in Patients With Early Breast Cancer According to Baseline Body Mass Index.
Abstract PURPOSE: Lipophilic drugs, such as taxanes, have a high affinity for adipose tissue and a resulting higher volume of distribution. Here, we reanalyzed clinical trial data to investigate whether the efficacy of docetaxel-based chemotherapy differs from non-docetaxel-based chemotherapy in patients with breast cancer according to their baseline body mass index (BMI). PATIENTS AND METHODS: We retrospectively analyzed data from all of the patients in the adjuvant BIG 2-98 trial (ClinicalTrials.gov identifier: NCT00174655; N = 2,887) comparing non-docetaxel- to docetaxel-containing chemotherapy. BMI (kg/m2...
Source: Clinical Genitourinary Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Desmedt C, Fornili M, Clatot F, Demicheli R, De Bortoli D, Di Leo A, Viale G, de Azambuja E, Crown J, Francis PA, Sotiriou C, Piccart M, Biganzoli E Tags: J Clin Oncol Source Type: research

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.
CONCLUSION: These findings establish CTCF loss as a major mediator in directing localized DNA hypermethylation events in a tissue-specific fashion and further support its role as a driver of the cancer phenotype. PMID: 32503656 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2020 Category: Cancer & Oncology Authors: Damaschke NA, Gawdzik J, Avilla M, Yang B, Svaren J, Roopra A, Luo JH, Yu YP, Keles S, Jarrard DF Tags: Clin Epigenetics Source Type: research

Personalised medicine and the decision to withhold chemotherapy in early breast cancer with intermediate risk of recurrence - a systematic review and meta-analysis.
CONCLUSION: Regarding the use of gene expression assays in breast cancer, evidence on patient effects, informing patient-level chemotherapy decision making, is available. However, evidence for prioritisation at the overall health care level, i.e. use of, versus no use of, such assays, is largely lacking. PMID: 32504183 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2020 Category: Cancer & Oncology Authors: Wallerstedt SM, Nilsson Ek A, Olofsson Bagge R, Kovács A, Strandell A, Linderholm B Tags: Eur J Clin Pharmacol Source Type: research

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
CONCLUSIONS: Taking all the interaction results together, the transporter cocktail is considered to be validated as a sensitive and specific tool for evaluating transporter-mediated drug-drug interactions in drug development. CLINICAL TRIAL REGISTRATION: EudraCT number 2017-001549-29. PMID: 32504272 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2020 Category: Cancer & Oncology Authors: Wiebe ST, Giessmann T, Hohl K, Schmidt-Gerets S, Hauel E, Jambrecina A, Bader K, Ishiguro N, Taub ME, Sharma A, Ebner T, Mikus G, Fromm MF, Müller F, Stopfer P Tags: Clin Pharmacokinet Source Type: research

Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer.
Conclusions: Our report is the first study to examine the distant metastatic breast cancer proteome using FFPE tissues. The depth of our dataset allowed us to discover a novel biomarker candidate and a proteomic characteristics of distant metastatic breast cancer. Distinct molecular features of various breast cancer subtypes were also established. Our proteomic data constitute a valuable resource for research on distant metastatic breast cancer. PMID: 32489334 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2020 Category: Cancer & Oncology Authors: Shin D, Park J, Han D, Moon JH, Ryu HS, Kim Y Tags: Clin Proteomics Source Type: research

Interaction between extracellular cancer matrix and stromal breast cells.
DISCUSSION: Our results clearly demonstrate that the tECM is able to shift the gene expression pattern of murine mammary epithelial cells towards that of carcinoma, indicating a role in breast cancer initiation. These data underlines that the acellular component of the tumor (ECM) can lead to a transformation of mammary gland tissue cells. These data show for the first time that the interaction of normal breast tissue cells with tumor ECM leads to an exchange of information and a consecutive overexpression of tumor-specific genes. PMID: 31796667 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 3, 2020 Category: Cancer & Oncology Authors: Gehmert S, Lehoczky G, Loibl M, Jung F, Prantl L, Gehmert S Tags: Clin Hemorheol Microcirc Source Type: research

Stereotactic Ablative Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers: Long-Term Results of the SABR-COMET Phase II Randomized Trial.
Abstract PURPOSE: The oligometastatic paradigm hypothesizes that patients with a limited number of metastases may achieve long-term disease control, or even cure, if all sites of disease can be ablated. However, long-term randomized data that test this paradigm are lacking. METHODS: We enrolled patients with a controlled primary malignancy and 1-5 metastatic lesions, with all metastases amenable to stereotactic ablative radiotherapy (SABR). We stratified by the number of metastases (1-3 v 4-5) and randomized in a 1:2 ratio between palliative standard-of-care (SOC) treatments (arm 1) and SOC plus SABR (arm 2)....
Source: Clinical Genitourinary Cancer - June 2, 2020 Category: Cancer & Oncology Authors: Palma DA, Olson R, Harrow S, Gaede S, Louie AV, Haasbeek C, Mulroy L, Lock M, Rodrigues GB, Yaremko BP, Schellenberg D, Ahmad B, Senthi S, Swaminath A, Kopek N, Liu M, Moore K, Currie S, Schlijper R, Bauman GS, Laba J, Qu XM, Warner A, Senan S Tags: J Clin Oncol Source Type: research

Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
Abstract Phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme of serine synthesis, is frequently overexpressed in human cancer. PHGDH overexpression activates serine synthesis to promote cancer progression. Currently, PHGDH regulation in normal cells and cancer is not well understood. Parkin, an E3 ubiquitin ligase involved in Parkinson's disease, is a tumor suppressor. Parkin expression is frequently downregulated in many types of cancer, and its tumor-suppressive mechanism is poorly defined. Here, we show that PHGDH is a substrate for Parkin-mediated ubiquitination and degradation. Parkin inter...
Source: Clinical Genitourinary Cancer - June 1, 2020 Category: Cancer & Oncology Authors: Liu J, Zhang C, Wu H, Sun XX, Li Y, Huang S, Yue X, Lu SE, Shen Z, Su X, White E, Haffty BG, Hu W, Feng Z Tags: J Clin Invest Source Type: research

Prior Treatment Time Affects Survival Outcomes in Metastatic Breast Cancer.
CONCLUSION: OS after a specific treatment is dependent on when a drug is given in the disease context, highlighting the potential for an overall OS benefit to be observed on the basis of treatment timing. Prior time on treatment should be considered as a stratifying factor in randomized trials and a confounding factor when examining survival in observational data. PMID: 32479187 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 1, 2020 Category: Cancer & Oncology Authors: Rocque GB, Gilbert A, Williams CP, Kenzik KM, Nakhmani A, Kandhare PG, Bhatia S, Burkard ME, Azuero A Tags: JCO Clin Cancer Inform Source Type: research

The prognostic factors of recurrence and survival in female patients with lung adenocarcinoma and breast cancer.
Abstract BACKGROUND: The aim of this study was to verify the predictors of recurrence and survival in lung adenocarcinoma patients with experiences of breast cancer therapies. METHODS: We retrospectively reviewed consecutive patients who were treated at our hospital for lung adenocarcinoma from 2004/01 to 2014/03. The patients were divided into groups of those with lung adenocarcinoma alone and those with lung and breast cancer. Kaplan-Meier plots and log-rank tests were used to estimate outcomes. RESULTS: 54 patients with lung adenocarcinoma and breast cancer were compared with 457 patients with single ...
Source: Clinical Genitourinary Cancer - April 18, 2020 Category: Cancer & Oncology Authors: Chen YY, Huang YJ, Huang HK, Chang H, Lee SC, Shieh YS, Huang TW Tags: J Cancer Res Clin Oncol Source Type: research

Low RAB6C expression is a predictor of tamoxifen benefit in estrogen receptor-positive/progesterone receptor-negative breast cancer.
Stål O Abstract Over the last few decades, improved and more individualized treatment has contributed to the increased survival rate of patients with breast cancer. However, certain patients may receive excessive treatment resulting in undesired side effects. In a previous study, it was demonstrated that systemically untreated patients with estrogen receptor (ER)-positive/progesterone receptor (PR)-negative tumors with high Ras-related protein Rab-6C (RAB6C) expression levels (RAB6C+) had prolonged distant recurrence-free survival compared with that of patients exhibiting low RAB6C (RAB6C-)-expressing tumors...
Source: Clinical Genitourinary Cancer - April 8, 2020 Category: Cancer & Oncology Authors: Fohlin H, Bekkhus T, Sandström J, Fornander T, Nordenskjöld B, Carstensen J, Stål O Tags: Mol Clin Oncol Source Type: research

Palbociclib added to ongoing endocrine therapy for hormone receptor-positive HER2-negative metastatic breast cancer: A case report series.
Abstract Palbociclib is a potent cyclin-dependent kinase (CDK)4/6 inhibitor that disrupts cell cycle progression and has been recently approved in combination with an aromatase inhibitor or fulvestrant as first- and second-line treatment in hormone receptor (HR)+, human epidermal growth factor receptor (HER)2- metastatic breast cancer. There is evidence that palbociclib may reverse endocrine therapy resistance and that it may also be added to ongoing endocrine therapy beyond progression to obtain clinical benefit. The aim of the present study was to explore this possibility in 5 patients who received palbociclib +...
Source: Clinical Genitourinary Cancer - April 8, 2020 Category: Cancer & Oncology Authors: Schettini F, Santo I, Rea CG, Viggiani M, Buono G, Angelis C, Cardalesi C, Lauria R, Giuliano M, Forestieri V, Thomas G, Maione P, Limite G, Accurso A, Malorni L, Placido S, Arpino G Tags: Mol Clin Oncol Source Type: research

International Guidelines on Radiation Therapy for Breast Cancer During the COVID-19 Pandemic.
PMID: 32241520 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 4, 2020 Category: Cancer & Oncology Authors: Coles CE, Aristei C, Bliss J, Boersma L, Brunt AM, Chatterjee S, Hanna G, Jagsi R, Kaidar Person O, Kirby A, Mjaaland I, Meattini I, Luis AM, Marta GN, Offersen B, Poortmans P, Rivera S Tags: Clin Oncol (R Coll Radiol) Source Type: research

Specialist nurse initiated interventions in breast cancer care: A systematic review of randomized controlled trials.
CONCLUSION: Even though specialist nursing interventions can contribute to health outcomes of women with breast cancer, there is limited number of studies reported from developing countries. This warrants the need for specialist nurse interventions in breast cancer care from developing countries. Relevance to clinical practice Offering a specialist nurse service helps the patients to meet their informational and educational needs, supportive care and coordination of care. Specialist breast nurse services can be integrated into hospital setting to improve patient care and treatment adherence. PMID: 32243012 [PubMed - a...
Source: Clinical Genitourinary Cancer - April 3, 2020 Category: Cancer & Oncology Authors: Hussain Rawther SC, Pai MS, J Fernandes D, Mathew S, Chakrabarty J, Devi ES Tags: J Clin Nurs Source Type: research

Effects of Health Belief Model based nursing interventions offered at home visits on lymphedema prevention in women with breast cancer: A randomized controlled trial.
CONCLUSION: The HBM based nursing interventions regularly offered at home visits can create positive changes in behaviour of lymphedema prevention and prevent lymphedema in women receiving radiotherapy after breast surgery. Considering costs of treatment for lymphedema, these interventions can be considered as cost-effective. RELEVANCE TO CLINICAL PRACTICE: Nursing interventions directed towards behaviour of preventing lymphedema and follow-ups in the long-term should be supported by home visits and reminders through phone calls. Nurses should perform HBM based interventions regularly at home visits to prevent lymphed...
Source: Clinical Genitourinary Cancer - April 3, 2020 Category: Cancer & Oncology Authors: Cal A, Bahar Z, Gorken I Tags: J Clin Nurs Source Type: research

Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline.
Abstract PURPOSE: To develop recommendations for management of patients with breast cancer (BC) with germline mutations in BC susceptibility genes. METHODS: The American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology convened an Expert Panel to develop recommendations based on a systematic review of the literature and a formal consensus process. RESULTS: Fifty-eight articles met eligibility criteria and formed the evidentiary basis for the local therapy recommendations; six randomized controlled trials of systemic therapy met eligibility criteria. ...
Source: Clinical Genitourinary Cancer - April 3, 2020 Category: Cancer & Oncology Authors: Tung NM, Boughey JC, Pierce LJ, Robson ME, Bedrosian I, Dietz JR, Dragun A, Gelpi JB, Hofstatter EW, Isaacs CJ, Jatoi I, Kennedy E, Litton JK, Mayr NA, Qamar RD, Trombetta MG, Harvey BE, Somerfield MR, Zakalik D Tags: J Clin Oncol Source Type: research

New Study Links Hair Chemicals to Breast Cancer.
PMID: 32239756 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 2, 2020 Category: Cancer & Oncology Authors: Fillon M Tags: CA Cancer J Clin Source Type: research

Volume de-escalation in radiation therapy: state of the art and new perspectives.
CONCLUSION: Further clinical trials are necessary to improve the identification of suitable patient cohorts and the extent of possible volume de-escalation that does not compromise tumor control. PMID: 32072318 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 1, 2020 Category: Cancer & Oncology Authors: Meduri B, Gregucci F, D'Angelo E, Alitto AR, Ciurlia E, Desideri I, Marino L, Borghetti P, Fiore M, Fiorentino A, AIRO Giovani -Italian Association of Radiation Oncology-Young Members Tags: J Cancer Res Clin Oncol Source Type: research

Expression of hypoxia-induced proteins in ductal carcinoma in situ and invasive cancer of the male breast.
CONCLUSIONS: In conclusion, male DCIS frequently shows activated hypoxia response, comparable to male IC. This indicates that the activated hypoxia response previously seen in male IC is not a late bystander but likely a genuine carcinogenetic event. PMID: 31653758 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 1, 2020 Category: Cancer & Oncology Authors: Vermeulen MA, van Deurzen CH, Schroder CP, Martens JW, van Diest PJ Tags: J Clin Pathol Source Type: research

Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review.
CONCLUSION: IHC was effective to detect loss of BRCA1 protein expression in EOC; however, data on BRCA2 expression were heterogeneous and difficult to interpret. PMID: 31719105 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 1, 2020 Category: Cancer & Oncology Authors: Teixeira LA, Candido Dos Reis FJ Tags: J Clin Pathol Source Type: research

Infantile macrocephaly and multiple subcutaneous lipomas diagnosed with PTEN hamartoma tumor syndrome: A case report.
Abstract A heterozygous loss-of-function mutation of the PTEN gene, one of the tumor suppressor genes, causes a wide variety of disorders, ranging from macrocephaly/autism syndrome to PTEN hamartoma tumor syndrome, including Cowden disease that causes thyroid and breast cancer mainly in the adolescence and young adult generation. An 8-month-old male infant with simple macrocephaly developed a café-au-lait spot and two subcutaneous tumors at the age of 1 year. One of the tumors developed rapidly was resected at the age of 1 year and 9 months and identified as benign lipoma. From the age of 2 years, the patie...
Source: Clinical Genitourinary Cancer - March 21, 2020 Category: Cancer & Oncology Authors: Yotsumoto Y, Harada A, Tsugawa J, Ikura Y, Utsunomiya H, Miyatake S, Matsumoto N, Kanemura Y, Hashimoto-Tamaoki T Tags: Mol Clin Oncol Source Type: research