Protective Association Between Calcium Channel Blocker Use and Breast Cancer Recurrence in Postsurgical Women: A Population-Based Case-Control Study in Taiwan.
This study uncovered a protective association between previous CCB use and breast cancer recurrence. PMID: 32020656 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Shih JH, Kao LT, Chung CH, Liao GS, Fann LY, Chien WC, Li IH Tags: J Clin Pharmacol Source Type: research

Multifocal breast cancers are more prevalent in BRCA2 versus BRCA1 mutation carriers.
This study investigates the prevalence of multifocality/multicentricity in a cohort of BRCA1/2 mutation carriers with breast cancer from Northern Ireland via cross-sectional analysis. Data from 211 women with BRCA1/2 mutations (BRCA1-91, BRCA2-120) and breast cancer were collected including age, tumour focality, size, type, grade and receptor profile. The prevalence of multifocality/multicentricity within this group was 25% but, within subgroups, prevalence amongst BRCA2 carriers was more than double that of BRCA1 carriers (p = 0.001). Women affected by MF/MC tumours had proportionately higher oestrogen receptor ...
Source: Clinical Genitourinary Cancer - February 5, 2020 Category: Cancer & Oncology Authors: McCrorie AD, Ashfield S, Begley A, Mcilmunn C, Morrison PJ, Boyd C, Eccles B, Greville-Heygate S, Copson ER, Cutress RI, Eccles DM, Savage KI, McIntosh SA Tags: J Pathol Clin Res Source Type: research

Clinical Cancer Advances 2020: Annual Report on Progress Against Cancer From the American Society of Clinical Oncology.
In this report, we explore how treatment successes have led to less invasive approaches for advanced melanoma, reduced the need for surgery in renal cell carcinoma, and increased the number of patients with pancreatic cancer who can undergo surgery.Many research advances are made possible by federal funding. With the number of new US cancer cases set to rise by roughly a third over the next decade, continued investment in research at the national level is crucial to continuing critical progress in the prevention, screening, diagnosis, and treatment of cancer.While clinical research has translated to longer survival and bet...
Source: Clinical Genitourinary Cancer - February 4, 2020 Category: Cancer & Oncology Authors: Markham MJ, Wachter K, Agarwal N, Bertagnolli MM, Chang SM, Dale W, Diefenbach CSM, Rodriguez-Galindo C, George DJ, Gilligan TD, Harvey RD, Johnson ML, Kimple RJ, Knoll MA, LoConte N, Maki RG, Meisel JL, Meyerhardt JA, Pennell NA, Rocque GB, Sabel MS, Sch Tags: J Clin Oncol Source Type: research

Prognostic significance of cathepsin V (CTSV/CTSL2) in breast ductal carcinoma in situ.
In this study, we aimed to evaluate the prognostic significance of CTSV in DCIS. METHODS: CTSV protein expression was immunohistochemically assessed in a well-characterised and annotated cohort of DCIS comprising pure DCIS (n=776) and DCIS coexisting with IBC (n=239). CTSV expression was analysed in tumour cells and surrounding stroma, including its association with clinicopathological parameters and outcome. RESULTS: In pure DCIS, high CTSV expression was observed in 29% of epithelial tumour cells and 20% of surrounding stroma. High expression in both components was associated with features of poor prognosis inc...
Source: Clinical Genitourinary Cancer - February 1, 2020 Category: Cancer & Oncology Authors: Toss M, Miligy I, Gorringe K, Mittal K, Aneja R, Ellis I, Green A, Rakha E Tags: J Clin Pathol Source Type: research

Cancer Survivorship Program: Implementation for Individuals With Recurrent Breast Cancer.
Abstract BACKGROUND: Patients are living longer with recurrent breast cancer, but survivorship programs for these individuals are lacking. OBJECTIVES: The aims were to implement a survivorship program for individuals with recurrent breast cancer, increase their quality of life (QOL), and evaluate patient satisfaction with the program. METHODS: Survivors were referred for a one-hour coaching intervention tailored to their needs based on results of the Functional Assessment of Cancer Therapy-Breast (FACT-B) survey. Satisfaction was assessed immediately and two weeks postintervention. A paired t test was us...
Source: Clinical Genitourinary Cancer - January 22, 2020 Category: Cancer & Oncology Authors: Burbage D, Duffy N, Johnson EJ, Schneider SM Tags: Clin J Oncol Nurs Source Type: research

Liquid Biopsy: A Tool for the Diagnostic and Prognostic Evaluation of Cancers.
This article provides an overview of liquid biopsy, its uses in cancer management, and its implications for nursing practice. PMID: 31961840 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 22, 2020 Category: Cancer & Oncology Authors: Stanciu J, Tariman JD Tags: Clin J Oncol Nurs Source Type: research

Considerations for the Telephone Disclosure of Genetic Test Results to Patients With Cancer.
Abstract I would like to thank Cantril, Moore, and Yan (2019) for their informative article on patient preferences for the disclosure of a breast cancer diagnosis in the December issue of the Clinical Journal of Oncology Nursing. The findings of Cantril et al.'s (2019) study suggest that patients prefer in-person disclosure. Additional patient priorities included knowing the results of tests quickly, having those results disclosed by an expert with a sensitive touch, and having a clear understanding of the next steps in the treatment plan. PMID: 31961845 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 22, 2020 Category: Cancer & Oncology Authors: Mahon SM Tags: Clin J Oncol Nurs Source Type: research

Male patient with metastatic stage IV breast cancer achieves complete remission on second line Abemaciclib, Fulvestrant and Leuprolide: A case report.
Abstract Male breast cancer occurs rarely, comprising
Source: Clinical Genitourinary Cancer - January 15, 2020 Category: Cancer & Oncology Authors: Hansra D, Jackson S, Sequeira J, Vazirani R, Alvarez R Tags: Mol Clin Oncol Source Type: research

Lenvatinib vs. palliative therapy for stage IVC anaplastic thyroid cancer.
Abstract Anaplastic thyroid cancer (ATC) is an orphan disease with extremely poor prognosis. In particular, unresectable stage IVC ATC is extremely difficult to treat and is associated with a survival of only a few months, even when treated with irradiation and/or chemotherapy. In 2015, lenvatinib was approved for the treatment of ATC in Japan. The aim of the present study was to evaluate the efficacy of lenvatinib for stage IVC ATC. A total of 32 patients with pathologically confirmed stage IVC ATC who were treated at the Kanagawa Cancer Center between 2011 and 2018 were included in the present study, of whom 16 ...
Source: Clinical Genitourinary Cancer - January 15, 2020 Category: Cancer & Oncology Authors: Iwasaki H, Toda S, Suganuma N, Murayama D, Nakayama H, Masudo K Tags: Mol Clin Oncol Source Type: research

Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update.
Abstract PURPOSE: To update key recommendations of the American Society of Clinical Oncology/College of American Pathologists estrogen (ER) and progesterone receptor (PgR) testing in breast cancer guideline. METHODS: A multidisciplinary international Expert Panel was convened to update the clinical practice guideline recommendations informed by a systematic review of the medical literature. RECOMMENDATIONS: The Expert Panel continues to recommend ER testing of invasive breast cancers by validated immunohistochemistry as the standard for predicting which patients may benefit from endocrine therapy, and no...
Source: Clinical Genitourinary Cancer - January 13, 2020 Category: Cancer & Oncology Authors: Allison KH, Hammond MEH, Dowsett M, McKernin SE, Carey LA, Fitzgibbons PL, Hayes DF, Lakhani SR, Chavez-MacGregor M, Perlmutter J, Perou CM, Regan MM, Rimm DL, Symmans WF, Torlakovic EE, Varella L, Viale G, Weisberg TF, McShane LM, Wolff AC Tags: J Clin Oncol Source Type: research

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts.
CONCLUSIONS: C3a-C3aR signaling in CAFs facilitates the metastasis of breast cancer. Targeting C3aR signaling is a potential anti-metastasis strategy for breast cancer therapy. PMID: 31931851 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 13, 2020 Category: Cancer & Oncology Authors: Shu C, Zha H, Long H, Wang X, Yang F, Gao J, Hu C, Zhou L, Guo B, Zhu B Tags: J Exp Clin Cancer Res Source Type: research

Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes.
CONCLUSION: HDACi suppress the epithelial-mesenchymal transition (EMT) and compromise the DNA integrity of cancer cells. These data encourage further testing of HDACi against tumor cells. PMID: 31932908 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 13, 2020 Category: Cancer & Oncology Authors: Kiweler N, Wünsch D, Wirth M, Mahendrarajah N, Schneider G, Stauber RH, Brenner W, Butter F, Krämer OH Tags: J Cancer Res Clin Oncol Source Type: research

Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma.
CONCLUSION: Uterine ML-AC represents a distinct subtype of invasive endometrial AC, associated with KRAS-mutations and characteristic immunohistochemical findings. Clinically, ML-AC may show an aggressive behavior with a high rate of recurrent disease and a substantial risk for distant metastatic disease, especially to the lungs. PMID: 31927619 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 11, 2020 Category: Cancer & Oncology Authors: Horn LC, Höhn AK, Krücken I, Stiller M, Obeck U, Brambs CE Tags: J Cancer Res Clin Oncol Source Type: research

Prognosis of BRCA1/2-negative breast cancer patients with HBOC risk factors compared with sporadic breast cancer patients without HBOC risk factors.
Abstract OBJECTIVE: Demands for genetic counseling with BRCA1/2 examination have markedly increased. Accordingly, the incidence of uninformative results on BRCA1/2 mutation status has also increased. Because most patients examined for BRCA1/2 mutation have a high risk of hereditary breast and/or ovarian cancer, many patients suffer psychological distress even when the BRCA1/2 result is negative. We compared oncological outcomes between BRCA1/2-negative breast cancer with high risk of hereditary breast and/or ovarian cancer and sporadic breast cancer without risk of hereditary breast and/or ovarian cancer. MET...
Source: Clinical Genitourinary Cancer - January 11, 2020 Category: Cancer & Oncology Authors: Ryu JM, Nam SJ, Kim SW, Lee JE, Chae BJ, Lee SK, Yu J Tags: Jpn J Clin Oncol Source Type: research

Cascading After Peridiagnostic Cancer Genetic Testing: An Alternative to Population-Based Screening.
CONCLUSION: Peridiagnostic and cascade cancer genetic testing offers an alternative strategy to achieve population-wide identification of cancer susceptibility mutations. PMID: 31922925 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 10, 2020 Category: Cancer & Oncology Authors: Offit K, Tkachuk KA, Stadler ZK, Walsh MF, Diaz-Zabala H, Levin JD, Steinsnyder Z, Ravichandran V, Sharaf RN, Frey MK, Lipkin SM, Robson ME, Hamilton JG, Vijai J, Mukherjee S Tags: J Clin Oncol Source Type: research

Comparison of the Efficacy and Safety of Pregabalin and Duloxetine in Taxane-Induced Sensory Neuropathy: A Randomized Controlled Trial.
This study aimed to compare the efficacy and safety of pregabalin (150 mg daily) and duloxetine (60 mg daily) for managing TIPN in breast cancer patients. METHODS: This randomized, double-blind, Phase II clinical trial was carried out at a chemotherapy center affiliated to Mazandaran University of Medical Sciences. Patients with breast cancer who received paclitaxel or docetaxel and had a grade 1 or more neuropathy (based on the National Cancer Institute Common Terminology Criteria for Adverse Events version (NCI-CTCAE v4.03), and who had score 4 or higher neuropathic pain severity [based on the visual analo...
Source: Clinical Genitourinary Cancer - January 10, 2020 Category: Cancer & Oncology Authors: Salehifar E, Janbabaei G, Hendouei N, Alipour A, Tabrizi N, Avan R Tags: Clin Drug Investig Source Type: research

Cancer statistics, 2020.
Abstract Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on population-based cancer occurrence. Incidence data (through 2016) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2017) were collected by the National Center for Health Statistics. In 2020, 1,806,590 new cancer cases and 606,520 cancer deaths are projected to occur in the United States....
Source: Clinical Genitourinary Cancer - January 8, 2020 Category: Cancer & Oncology Authors: Siegel RL, Miller KD, Jemal A Tags: CA Cancer J Clin Source Type: research

Metformin-repressed miR-381-YAP-snail axis activity disrupts NSCLC growth and metastasis.
CONCLUSIONS: Metformin-induced repression of miR-381-YAP-Snail axis activity disrupts NSCLC growth and metastasis. Thus, we believe that the miR-381-YAP-Snail signal axis may be a suitable diagnostic marker and a potential therapeutic target for lung cancer. PMID: 31906986 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 6, 2020 Category: Cancer & Oncology Authors: Jin D, Guo J, Wu Y, Chen W, Du J, Yang L, Wang X, Gong K, Dai J, Miao S, Li X, Su G Tags: J Exp Clin Cancer Res Source Type: research

Long non-coding RNAE330013P06 promotes progression of breast cancer with type 2 diabetes.
CONCLUSION: Upregulation of LncRNAE330013P06 driven by type 2 diabetes is one of the factors which promoted progression of breast cancer. PMID: 31907990 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 6, 2020 Category: Cancer & Oncology Authors: Chen R, Shi P, Zhang Y, Wu H, Li X, Yang W, Luo F, JinmingXue, Yao L, Yang J, Wang W, Zhang B, Li P, Miao Y, Wang Q, Tian F Tags: J Clin Lab Anal Source Type: research

Postmenopausal dense breasts maintain premenopausal levels of GH and insulin-like growth factor binding proteins in vivo.
Abstract CONTEXT: Dense breast tissue is associated with 4-6 times higher risk of breast cancer by poorly understood mechanisms. No preventive therapy for this high-risk group is available. After menopause breast density decreases due to involution of the mammary gland. In dense breast tissue this process is haltered by undetermined biological actions. Growth hormone (GH) and insulin-like binding proteins (IGFBPs) play major roles in normal mammary gland development but their roles in maintaining breast density are unknown. OBJECTIVE: To reveal in vivo levels of GH, IGFBPs, and other pro-tumorigenic proteins ...
Source: Clinical Genitourinary Cancer - January 4, 2020 Category: Cancer & Oncology Authors: Dabrosin N, Dabrosin C Tags: J Clin Endocrinol Metab Source Type: research

Elevated HDAC activity and altered histone phospho-acetylation confer acquired radio-resistant phenotype to breast cancer cells.
CONCLUSION: The study revealed that an imbalance of HAT and HDAC activities led to the loss of site-specific histone acetylation and chromatin compaction as breast cancer cells acquired radio-resistance. Due to variation in the tumor HDAC activity among patients, our report suggests performing a prior assessment of the tumor epigenome to maximize the benefit of HDAC inhibitor-based radio-sensitization. PMID: 31900196 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 3, 2020 Category: Cancer & Oncology Authors: Sharda A, Rashid M, Shah SG, Sharma AK, Singh SR, Gera P, Chilkapati MK, Gupta S Tags: Clin Epigenetics Source Type: research

MicroRNA-769-5p suppresses cell growth and migration via targeting NUSAP1 in bladder cancer.
CONCLUSION: This study demonstrates that miR-769-5p functions as a tumor suppressor in bladder cancer via targeting NUSAP1. PMID: 31901150 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 3, 2020 Category: Cancer & Oncology Authors: Chen Y, Zhang W, Kadier A, Zhang H, Yao X Tags: J Clin Lab Anal Source Type: research

Frailty and diabetes status in older patients with cancer: impact on mortality in the ANCRAGE cohort.
Abstract BACKGROUND: Frailty, diabetes and cancer are associated with aging, but the relationship between these conditions is not well defined. AIMS: We studied older patients with cancer from the prospective single-center cohort ANCRAGE (ANalyses of CanceR in AGEd) aiming to determine the impact of type 2 diabetes (T2D) and its vascular complications (VC) on frailty and adverse outcomes (mortality, unplanned readmission) during follow-up. METHODS: Analysis of cohort patients ≥ 75 years, included between 2009 and 2017, who underwent a comprehensive geriatric assessment (CGA). Variab...
Source: Clinical Genitourinary Cancer - January 2, 2020 Category: Cancer & Oncology Authors: Liuu E, Saulnier PJ, Gand E, Ragot S, Valero S, Jamet A, Hadjadj S, Paccalin M Tags: Aging Clin Exp Res Source Type: research

Diagnostic value of seven biomarkers for breast cancer: an overview with evidence mapping and indirect comparisons of diagnostic test accuracy.
In conclusion, miRNA had better diagnostic accuracy than the other six biomarkers. But due to the low quality of included SRs, the results need to be interpreted with caution. Further study should investigate the diagnostic accuracy of different biomarkers in direct comparisons and focus on the value of combined biomarkers. PMID: 31894424 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 1, 2020 Category: Cancer & Oncology Authors: Gao Y, Liu M, Shi S, Sun Y, Li M, Zhang M, Sheng Z, Zhang J, Tian J, Cancer Biomarker Assessment Working Group Tags: Clin Exp Med Source Type: research

MED12, TERT and RARA in fibroepithelial tumours of the breast.
Abstract Fibroepithelial tumours are biphasic neoplasms of the breast comprising the common benign fibroadenomas and the less common phyllodes tumours (PTs), which have recurrent potential. PTs are classified into benign, borderline or malignant, based on five histopathological criteria, with malignant PTs having the highest metastatic capability. Accurate diagnosis can be challenging due to the subjective assessment of histopathological parameters. Fibroadenomas bear morphological similarities to benign PTs, while borderline and malignant PTs can sometimes be difficult to distinguish from other spindle cell tumou...
Source: Clinical Genitourinary Cancer - December 25, 2019 Category: Cancer & Oncology Authors: Chang HY, Koh VCY, Md Nasir ND, Ng CCY, Guan P, Thike AA, Teh BT, Tan PH Tags: J Clin Pathol Source Type: research

E-Coaching: the DianaWeb study to prevent breast cancer recurrences.
CONCLUSIONS: The high number of participants' interaction within the web page, confirmed the high usability of the web page and the great interest of patients. Prevention of breast cancer recurrences with low cost technologies, easily available to everybody, is a priority for both public health and public finances. PMID: 31850486 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 19, 2019 Category: Cancer & Oncology Authors: Gianfredi V, Nucci D, Balzarini M, Acito M, Moretti M, Villarini A, Villarini M Tags: Clin Ter Source Type: research

Quantitative assessment of radiodermatitis through a non-invasive objective procedure in patients with breast cancer.
Abstract Assessment of skin condition is necessary for providing advice regarding skin self-care to patients with breast cancer who have undergone radiation therapy. Acute and chronic phases of radiodermatitis were analyzed in patients using objective assessment tools in the present study. A total of 18 women who received radiation therapy for breast cancer were enrolled in the present study and their skin surface temperature (SST), hydration level of the skin surface (HL), melanin intensity (MI) and erythema intensity (EI) were measured prior to radiation therapy and six months thereafter. Furthermore, skin condi...
Source: Clinical Genitourinary Cancer - December 11, 2019 Category: Cancer & Oncology Authors: Kitajima M, Mikami K, Noto Y, Itaki C, Fukushi Y, Hirota Y, Mariya Y, Tsushima M, Kattou K, Osanai T Tags: Mol Clin Oncol Source Type: research

Precision Medicine and Targeted Therapies in Breast Cancer.
This article describes the foundation and future of targeted therapy and precision medicine in breast cancer. PMID: 31757313 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 25, 2019 Category: Cancer & Oncology Authors: Greenwalt I, Zaza N, Das S, Li BD Tags: Surg Oncol Clin N Am Source Type: research

Tumor-infiltrating lymphocytes and CD8+ T cells predict survival of triple-negative breast cancer.
Abstract PURPOSE: Tumor inflammatory response was evaluated as a prognostic feature in triple-negative breast cancer (TNBC) and compared with the clinical prognosticators of breast cancer and selected biomarkers of cancer cell proliferation. METHODS: TNBC patients (n = 179) with complete clinical data and up to 18-year follow-up were obtained from Auria biobank, Turku University Hospital, Turku, Finland. Tumor-infiltrating lymphocytes (TILs) and several subtypes of inflammatory cells detected with immunohistochemistry were evaluated in different tumor compartments in full tissue sections and tis...
Source: Clinical Genitourinary Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Vihervuori H, Autere TA, Repo H, Kurki S, Kallio L, Lintunen MM, Talvinen K, Kronqvist P Tags: J Cancer Res Clin Oncol Source Type: research

Variability of predictive markers (hormone receptors, Her2, Ki67) and intrinsic subtypes of breast cancer in four consecutive years 2015-2018.
CONCLUSIONS: Predictive markers displayed a yearly similar distribution in breast cancer cases independently of grading or of intrinsic subtypes. These results point to a qualitative high performance of predictive marker assessment in breast cancer, corresponding to expected on average positivity rate per marker and per year. It is recommended to monitor positivity rate of ER, PR, Ki67 and Her2 yearly or periodically to comply with quality assurance requirements. PMID: 31628534 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Stevanovic L, Choschzick M, Moskovszky L, Varga Z Tags: J Cancer Res Clin Oncol Source Type: research

Oncogenic potential of nucleoporins in non-hematological cancers: recent update beyond chromosome translocation and gene fusion.
CONCLUSION: Although classically, majority of studies have shown oncogenic roles of nucleoporins as genetic fusion partners in several types of leukemia, emerging evidence suggests that nucleoporins also modulate many cellular signaling pathways that are associated with several major non-hematological malignancies, such as carcinomas of skin, breast, lung, prostate and colon. Hence, nucleoporins are emerging as novel therapeutic targets in human tumors. PMID: 31654122 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 23, 2019 Category: Cancer & Oncology Authors: Roy A, Narayan G Tags: J Cancer Res Clin Oncol Source Type: research

Cardiac death after breast radiotherapy and the QUANTEC cardiac guidelines.
Abstract Background: Breast/chest wall irradiation (RT) increases risk of cardiovascular death. International Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) guidelines state for partial heart irradiation a "V25Gy
Source: Clinical Genitourinary Cancer - September 6, 2019 Category: Cancer & Oncology Authors: Beaton L, Bergman A, Nichol A, Aparicio M, Wong G, Gondara L, Speers C, Weir L, Davis M, Tyldesley S Tags: Clin Transl Radiat Oncol Source Type: research

Neutral diagnosis: An innovative concept for medical device clinical trials.
Abstract Study design and statistical analysis are crucial in pivotal clinical trials to evaluate the effectiveness and safety of new medical devices under investigation. In recent years, innovative intraoperative in vivo breast tumor diagnostic devices have been proposed to improve the accuracy and surgical outcomes of breast tumor patients undergoing resection. Although such technologies are promising, investigators need to obtain statistical evidence for the effectiveness and safety of these devices by conducting valid clinical trials. However, the study design and statistical analysis for these clinical trials...
Source: Clinical Genitourinary Cancer - September 6, 2019 Category: Cancer & Oncology Authors: Zhang B, Ye S, Shankara SB, Zhang H, Zheng Q Tags: Contemp Clin Trials Commun Source Type: research

Effectiveness of early rehabilitation on range of motion, muscle strength and arm function after breast cancer surgery: a systematic review of randomized controlled trials.
CONCLUSION: Both ROM and strengthening exercises associated with ROM exercises improved shoulder flexion, abduction and external rotation ROM after BCS. Shoulder abduction and external rotation showed less recovery, irrespective of the intervention applied. PMID: 31480855 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Ribeiro IL, Moreira RFC, Ferrari AV, Alburquerque-Sendín F, Camargo PR, Salvini TF Tags: Clin Rehabil Source Type: research

Fluorescence lifetime-based tumor contrast enhancement using an EGFR antibody labeled near infrared fluorophore.
CONCLUSIONS: Our data suggest that FLT can significantly enhance tumor contrast using fluorescently labeled antibodies, thereby accelerating the efficient clinical application of these probes for margin assessment in image guided surgery and for highly specific detection of tumor receptors in-vivo. PMID: 31481509 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Pal R, Kang H, Choi HS, Kumar ATN Tags: Clin Cancer Res Source Type: research

Breast metastasis from rectal cancer with BRAF V600E mutation: a case report with a review of the literature.
We report the case of a 67-year-old woman with a metastatic breast tumor derived from a BRAF V600E mutant rectal carcinoma that was diagnosed and resected curatively 1 year previously. Computed tomography showed a left breast mass and multiple lung nodules suspected to be indicative of recurrent rectal cancer. The ultrasonography examination demonstrated a 10 × 10-mm hypoechoic solid lesion in the left breast with an elevation in the serum carcinoembryonic antigen level and serum carbohydrate antigen 19-9 level. Core needle biopsy was performed, and histopathologic examination showed Cytokeratin 20...
Source: Clinical Genitourinary Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Hasegawa H, Nagata Y, Sakakibara Y, Miyake M, Mori K, Masuda N, Mano M, Nakazuru S, Ishida H, Mita E Tags: Clin J Gastroenterol Source Type: research

Use of Endocrine Therapy for Breast Cancer Risk Reduction: ASCO Clinical Practice Guideline Update.
Abstract PURPOSE: To update the ASCO guideline on pharmacologic interventions for breast cancer risk reduction and provide guidance on clinical issues that arise when deciding to use endocrine therapy for breast cancer risk reduction. METHODS: An Expert Panel conducted targeted systematic literature reviews to identify new studies. RESULTS: A randomized clinical trial that evaluated the use of anastrozole for reduction of estrogen receptor-positive breast cancers in postmenopausal women at increased risk of developing breast cancer provided the predominant basis for the update. UPDATED RECOMMENDATIO...
Source: Clinical Genitourinary Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Visvanathan K, Fabian CJ, Bantug E, Brewster AM, Davidson NE, DeCensi A, Floyd JD, Garber JE, Hofstatter EW, Khan SA, Katapodi MC, Pruthi S, Raab R, Runowicz CD, Somerfield MR Tags: J Clin Oncol Source Type: research

Practical application of non-contact alternating current electric field mixing for reagent-saving in situ hybridisation of HER2.
CONCLUSIONS: These results suggest reagent-saving HER2 ISH could be used as a clinical tool for accurate and stable HER2 assessment, even when reagent concentrations vary. PMID: 31129615 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 1, 2019 Category: Cancer & Oncology Authors: Kurihara N, Imai K, Nanjo H, Nakamura R, Wakamatsu Y, Akagami K, Terata K, Wakita A, Sato Y, Motoyama S, Akagami Y, Minamiya Y Tags: J Clin Pathol Source Type: research

The vulvar immunohistochemical panel (VIP) project: molecular profiles of vulvar Paget's disease.
CONCLUSIONS: This study reveals the expression of PDL-1 and ER and confirms the expression of HER2/AR in VPD; new bases are provided to design multicenter clinical trials on personalized target therapies. PMID: 31297606 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 30, 2019 Category: Cancer & Oncology Authors: Garganese G, Inzani F, Mantovani G, Santoro A, Valente M, Babini G, Petruzzellis G, Fragomeni SM, Gentileschi S, Bove S, Franchi M, Angelico G, Fagotti A, Scambia G, Zannoni GF Tags: J Cancer Res Clin Oncol Source Type: research

Identification of Prognostic Candidate Genes in Breast Cancer by Integrated Bioinformatic Analysis.
Abstract Breast cancer is one of the most common malignancies. However, the molecular mechanisms underlying its pathogenesis remain to be elucidated. The present study aimed to identify the potential prognostic marker genes associated with the progression of breast cancer. Weighted gene coexpression network analysis was used to construct free-scale gene coexpression networks, evaluate the associations between the gene sets and clinical features, and identify candidate biomarkers. The gene expression profiles of GSE48213 were selected from the Gene Expression Omnibus database. RNA-seq data and clinical information ...
Source: Clinical Genitourinary Cancer - August 2, 2019 Category: Cancer & Oncology Authors: Wang CCN, Li CY, Cai JH, Sheu PC, Tsai JJP, Wu MY, Li CJ, Hou MF Tags: J Clin Med Source Type: research

When Should we Irradiate the Primary in Metastatic Lung Cancer?
Abstract Metastatic lung cancer encompasses a heterogenous group of patients in terms of burdens of disease, ranging from patients with extensive metastases to those with a limited number of metastatic lesions (oligometastatic disease). Histopathological heterogeneity also exists within two broad categories, non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC), portraying different patterns and evolution of disease. Local consolidative therapy to the primary tumour and metastatic sites, including surgery and/or radical dose radiotherapy, is increasingly being used to improve survival outcomes, part...
Source: Clinical Genitourinary Cancer - August 2, 2019 Category: Cancer & Oncology Authors: Shiarli AM, McDonald F, Gomez DR Tags: Clin Oncol (R Coll Radiol) Source Type: research

Co-expression network analysis identified candidate biomarkers in association with progression and prognosis of breast cancer.
CONCLUSIONS: AGO2, CDC20, CDCA5, MCM10, MYBL2, and TTK were identified as candidate biomarkers for further basic and clinical research on breast cancer based on co-expression analysis. PMID: 31280346 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 6, 2019 Category: Cancer & Oncology Authors: Zhou Q, Ren J, Hou J, Wang G, Ju L, Xiao Y, Gong Y Tags: J Cancer Res Clin Oncol Source Type: research

Erector spinae plane block and thoracic paravertebral block for breast surgery compared to IV-morphine: A randomized controlled trial.
l;koğlu UH Abstract STUDY OBJECTIVE: Erector spinae plane (ESP) block is a novel regional anesthesia technique and gaining importance for postoperative pain management. Since it was first described, the clinicians wonder if this new simple technique can replace paravertebral block (PVB). We aimed to compare the postoperative analgesic effect of ESP block and PVB with a control group in breast surgeries. DESIGN: Randomized controlled trial. SETTING: Operating room. PATIENTS: Seventy-five ASA I-II patients aged 25-65, who were scheduled to go under elective unilateral breast surgery for breast cancer...
Source: Clinical Genitourinary Cancer - July 4, 2019 Category: Cancer & Oncology Authors: Gürkan Y, Aksu C, Kuş A, Yörükoğlu UH Tags: J Clin Anesth Source Type: research

Role of Mast Cells in Shaping the Tumor Microenvironment.
Abstract Early mast cell (MC) infiltration has been reported in a wide range of human and animal tumors particularly malignant melanoma and breast and colorectal cancer. The consequences of their presence in the tumor microenvironment (TME) or at their margins still remain unclear as it is associated with a good or poor prognosis based on the type and anatomical site of the tumor. Within the tumor, MC interactions occur with infiltrated immune cells, tumor cells, and extracellular matrix (ECM) through direct cell-to-cell interactions or release of a broad range of mediators capable of remodeling the TME. MCs activ...
Source: Clinical Genitourinary Cancer - June 29, 2019 Category: Cancer & Oncology Authors: Komi DEA, Redegeld FA Tags: Clin Rev Allergy Immunol Source Type: research

Breast cancer and cytomegalovirus.
CONCLUSIONS: Overall, the results of published studies of cytomegalovirus and breast cancer suggest cytomegalovirus is a causal factor for at least some types of breast cancer. If the evidence for a link between cytomegalovirus and breast cancer continues to strengthen, further research could lead to: targeted screening; therapy using antiviral drugs; and, perhaps, primary prevention of a significant proportion of breast cancer. Vaccination against viruses has already been shown to be effective in preventing cervix and liver cancer; cytomegalovirus vaccines are already under development. PMID: 31256361 [PubMed - as su...
Source: Clinical Genitourinary Cancer - June 29, 2019 Category: Cancer & Oncology Authors: Richardson AK, Walker LC, Cox B, Rollag H, Robinson BA, Morrin H, Pearson JF, Potter JD, Paterson M, Surcel HM, Pukkala E, Currie MJ Tags: Clin Transl Oncol Source Type: research

Paraneoplastic neuromyelitis optica spectrum disorder associated with breast cancer.
Abstract Neuromyelitis optica spectrum disorder (NMOSD) is a group of inflammatory disease involving the central nervous system. Although most commonly an idiopathic autoimmune condition, NMOSD may also occur as a paraneoplastic syndrome in rare instances. Herein, we report a rare case of a 60-year-old woman with paraneoplastic NMOSD associated with breast cancer. Our findings increase the recognition that NMOSD may present as a paraneoplastic neurological syndrome associated with breast cancer. Our case also raises awareness of an important complication of neurological complications of breast cancer. Early diagno...
Source: Clinical Genitourinary Cancer - June 28, 2019 Category: Cancer & Oncology Authors: Yuan J, Jia Z, Qin W, Hu W Tags: Clin Interv Aging Source Type: research

Should All Patients With a Diagnosis of Breast Cancer Undergo Expanded Panel Testing?
PMID: 31246525 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 27, 2019 Category: Cancer & Oncology Authors: Copur MS, Jonglertham P, Zusag T Tags: J Clin Oncol Source Type: research

Caveat Emptor: The Perils of Panel Testing in Hereditary Breast Cancer.
PMID: 31246528 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 27, 2019 Category: Cancer & Oncology Authors: Taylor A, Tischkowitz M Tags: J Clin Oncol Source Type: research

The Time for Mainstreaming Germline Testing for Patients With Breast Cancer Is Now.
PMID: 31246531 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 27, 2019 Category: Cancer & Oncology Authors: Rajagopal PS, Catenacci DVT, Olopade OI Tags: J Clin Oncol Source Type: research

Efflux Transport of Nicotine, Cotinine and Trans-3'-hydroxycotinine glucuronides by Human Hepatic Transporters.
This article is protected by copyright. All rights reserved. PMID: 31237077 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 24, 2019 Category: Cancer & Oncology Authors: Järvinen E, Sjöstedt N, Koenderink JB, Kidron H, Finel M Tags: Basic Clin Pharmacol Toxicol Source Type: research