Detection of Circulating Tumor Cells in Cerebrospinal Fluid of Patients with Suspected Breast Cancer Leptomeningeal Metastases: A Prospective Study
CONCLUSIONS: The clinical sensitivity of CTC detection in CSF with the CellSearch® system for LM diagnosis is higher than that of CSF cytology. CTC detection in patients with negative cytology, however, must be further investigated. The finding of HER2+ CTCs in patients with HER2- BC suggests that the HER2 status of LM should be evaluated to increase the treatment opportunities for these patients.PMID:35953885 | DOI:10.1093/clinchem/hvac127 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Am élie Darlix Laure Cayrefourcq St éphane Pouderoux Nicolas Menjot de Champfleur Alexis Bievelez William Jacot Cristina Leaha Simon Thezenas Catherine Alix-Panabi ères Source Type: research

Adenoid Cystic Carcinoma of the Breast May Be Exempt from Adjuvant Chemotherapy
J Clin Med. 2022 Jul 31;11(15):4477. doi: 10.3390/jcm11154477.ABSTRACTConsistent standards regarding whether postoperative adjuvant chemotherapy is required in the treatment of adenoid cystic carcinoma of the breast (ACCB) are currently lacking. Using clinical data from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2015), and the National Cancer Center of China (2004-2020), we retrospectively analyzed patients with ACCB who received radical treatment. A total of 661 patients were eligible. The median age at diagnosis was 61 years; 99.5% of patients were initially diagnosed with stage I and II breast...
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Lixi Li Di Zhang Fei Ma Source Type: research

Effect of Serum Lipid Profile on the Risk of Breast Cancer: Systematic Review and Meta-Analysis of 1,628,871 Women
J Clin Med. 2022 Aug 2;11(15):4503. doi: 10.3390/jcm11154503.ABSTRACTDyslipidemia has been linked to breast cancer incidence. The aim of the present meta-analysis was to further investigate the relationship between the serum lipid profile and breast cancer risk. Databases such as PubMed, EMBASE, and Web of Sciences were searched up to the end of January 2021 using certain MeSH and non-MeSH keywords and combinations to extract related published articles. Twenty-six prospective studies involving 1,628,871 women, of whom 36,590 were diagnosed with breast cancer during the follow-up period met the inclusion criteria. A negativ...
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Mehran Nouri Mohammad Ali Mohsenpour Niki Katsiki Saeed Ghobadi Alireza Jafari Shiva Faghih Maciej Banach Mohsen Mazidi Source Type: research

"Tear-Drop Appearance" Wrap: A Novel Implant Coverage Method for Creating Natural Contour in Prepectoral Prosthetic-Based Breast Reconstruction
J Clin Med. 2022 Aug 5;11(15):4592. doi: 10.3390/jcm11154592.ABSTRACTVarious implant wrapping methods with acellular dermal matrix (ADM) have been introduced, but most focus on random trimming and suturing aimed to maximize implant coverage. Here we present our clinical experience using a "tear-drop appearance" wrapping method to achieve natural contours through upper pole volume replacement. We retrospectively reviewed the data of 56 consecutive cases of prepectoral prosthetic-based breast reconstruction (PPBR) using this wrapping method following nipple-sparing mastectomy between March 2020 and June 2021. The "tear-drop ...
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Hong-Il Kim Byeong-Seok Kim Jin-Hyung Park Hyung-Suk Yi Hyo-Young Kim Jin-Hyuk Choi Sung-Ui Jung Yoon-Soo Kim Source Type: research

Dual BRCA1 and BRCA2 pathogenic variants in an adolescent with syndromic intellectual disability
We present a 15-year-old female patient with syndromic intellectual disability whose exome reanalysis identified secondary findings of pathogenic BRCA1 and BRCA2 variants, both inherited paternally. We discuss the significant challenges posed by this finding in genetic counseling and cancer risk management of an adolescent with nonverbal intellectual disability, as well as the impact on their family. This rare case highlights the potential increased diagnostic yield of whole exome sequencing reanalysis and the consequences of secondary medically actionable results in a pediatric patient.PMID:35957765 | PMC:PMC9360338 | DOI...
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Arash Algouneh Michelle Caudle Tugce Balci Andrea Andrade Debbie Penava Maha Saleh Source Type: research

Pilot Study of Combination Gemogenovatucel-T (Vigil) and Durvalumab in Women With Relapsed BRCA-wt Triple-Negative Breast or Ovarian Cancer
CONCLUSIONS: Vigil plus durvalumab was well tolerated and showed promising clinical activity in advanced BRCA-wt TNBC and stage III-IV recurrent/refractory OC patients.PMID:35957960 | PMC:PMC9358582 | DOI:10.1177/11795549221110501 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Minal Barve Phylicia Aaron Luisa Manning Ernest Bognar Gladice Wallraven Staci Horvath Laura Stanbery John Nemunaitis Source Type: research

RUBY: Natural Language Processing of French Electronic Medical Records for Breast Cancer Research
CONCLUSION: These results show that the automatic approach has the potential to effectively extract clinical knowledge from an extensive set of electronic medical records, reducing the manual effort required and saving a significant amount of time. A deeper semantic analysis and further understanding of the context in the text, as well as training on a larger and more recent set of reports, including those containing highly variable entities and the use of ontologies, could further improve the results.PMID:35960900 | DOI:10.1200/CCI.21.00199 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 12, 2022 Category: Cancer & Oncology Authors: Renaud Schiappa Sara Contu Dorian Culie Brice Thamphya Yann Chateau Jocelyn Gal Caroline Bailleux Juliette Haudebourg Jean-Marc Ferrero Emmanuel Barranger Emmanuel Chamorey Source Type: research

Expression of KIF2A, NDC80, CDK1, and CCNB1 in breast cancer patients: Their interaction and linkage with tumor features and prognosis
CONCLUSION: KIF2A correlates with NDC80, CDK1, CCNB1, and may link with advanced tumor stages and poor prognosis in breast cancer patients.PMID:35949045 | DOI:10.1002/jcla.24647 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Cong Wang Xianxin Xie Weijie Li Daqing Jiang Source Type: research

Invasive ductal carcinoma of breast with neuroendocrine differentiation: A case report
Clin Case Rep. 2022 Aug 5;10(8):e6171. doi: 10.1002/ccr3.6171. eCollection 2022 Aug.ABSTRACTPrimary invasive breast carcinoma with neuroendocrine differentiation is an uncommon presentation. We hereby report a case diagnosed as invasive ductal carcinoma with neuroendocrine differentiation in a 52-year-old female patient who presented with a painless right breast lump.PMID:35949409 | PMC:PMC9354097 | DOI:10.1002/ccr3.6171 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Vinayak Aryal Moushami Singh Karun Neupane Adwait Marhatta Kapendra S Amatya Hari P Dhakal Source Type: research

Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells
CONCLUSION: Our findings point to nAChRs as responsible for the decrease in the chemotherapeutic effect of paclitaxel in triple negative tumors. Thus, nAChRs should be considered as targets in smoking patients.PMID:35949430 | PMC:PMC9244968 | DOI:10.5306/wjco.v13.i6.505 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Alejandro Espa ñol Yamila Sanchez Agustina Salem Jaqueline Obregon Maria Elena Sales Source Type: research

Significance of serum carcinoembryonic antigen in metastatic breast cancer patients: A prospective study
CONCLUSION: Elevated post-treatment serum CEA levels are associated with disease progression and poor response to therapy. Persistently elevated post-treatment serum CEA levels are significantly associated with bone metastases. Elevated serum CEA and hormonal status are significant predictors of treatment response.PMID:35949431 | PMC:PMC9244974 | DOI:10.5306/wjco.v13.i6.529 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Thattungal Manoharan Anoop Rona Joseph P Saikumar Soman Steffi Chacko Mintu Mathew Source Type: research

Concordance between Ki-67 index in invasive breast cancer and molecular signatures: EndoPredict and MammaPrint
In conclusion, there was a concordance between Ki-67 and MammaPrint risk stratification of HR+ EIBC and no concordance with the EndoPredict molecular signature, but a positive association with the given percentage of recurrence and the median Ki-67 index as the cutoff at our center. Cost-effectiveness analyses of these tests in developing countries are required; until then, the use of Ki-67 appears reasonable to aid clinical decisions, together with the other established clinicopathological variables.PMID:35949891 | PMC:PMC9353786 | DOI:10.3892/mco.2022.2565 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Jes ús Eduardo Amezcua-Gálvez Carlos A Lopez-Garcia Cynthia Villarreal-Garza Victor Lopez-Rivera Mauricio Canavati-Marcos Sandra Santuario-Facio Antonio Dono Paloma Del C Monroig-Bosque Roc ío Ortiz-López Andrea Leal-Lopez Gabriela Sof ía Gómez-Mac Source Type: research

Long-term survival of a < em > BRCA2 < /em > mutation carrier following second ovarian cancer relapse using PARPi therapy: A case report
Mol Clin Oncol. 2022 Jul 21;17(3):137. doi: 10.3892/mco.2022.2570. eCollection 2022 Sep.ABSTRACTBRCA1/2 mutation carriers have lifelong increased risks of developing breast and ovarian cancer. Due to the lack of efficient ovarian cancer screening, patients mainly present when the tumors are at an advanced stage, and the long-term survival is poor. The application of poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) has been used in personalized cancer treatment. Specific strategies to improve the outcome of patients are available and mainly include targeting of BRCA1 or BRCA2 mutations. The aim of the present study was...
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Kathrin Bredow Britta Bl ümcke Stephanie Schneider Michael P üsken Rita Schmutzler Kerstin Rhiem Source Type: research

Smart Start: Rituximab, Lenalidomide, and Ibrutinib in Patients With Newly Diagnosed Large B-Cell Lymphoma
CONCLUSION: Smart Start is the first study, to our knowledge, to treat newly diagnosed DLBCL with a targeted therapy combination before chemotherapy. RLI produced a high ORR, and RLI with chemotherapy resulted in durable responses. This establishes the potential for developing biologically driven and noncytotoxic first-line therapies for DLBCL.PMID:35952327 | DOI:10.1200/JCO.22.00597 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Jason Westin R Eric Davis Lei Feng Fredrick Hagemeister Raphael Steiner Hun Ju Lee Luis Fayad Loretta Nastoupil Sairah Ahmed Alma Rodriguez Michelle Fanale Felipe Samaniego Swaminathan P Iyer Ranjit Nair Yasuhiro Oki Nathan Fowler Michael Wang Man Chun Jo Source Type: research

Combination Treatment of Vinorelbine With Oral Cyclophosphamide or Capecitabine or Both Might Overcome Cross-resistance Against Eribulin in Advanced Breast Cancer
Clin Breast Cancer. 2022 Jul 25:S1526-8209(22)00173-2. doi: 10.1016/j.clbc.2022.07.011. Online ahead of print.NO ABSTRACTPMID:35953413 | DOI:10.1016/j.clbc.2022.07.011 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 11, 2022 Category: Cancer & Oncology Authors: Kadri Altundag Source Type: research