Haplotype Analysis of Vitamin D Receptor (VDR) Gene in Breast Cancer Patients
CONCLUSIONS: All these data support the hypothesis that it is crucial to evaluate VDR gene polymorphism by haplotype analysis in order to understand how changes in VDR sequence influence the function of the VDR gene and how this variability affects the risk of breast cancer.PMID:34107637 | DOI:10.7754/Clin.Lab.2020.200931 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 10, 2021 Category: Cancer & Oncology Authors: Emel Ergul Turgay Simsek Nihal Uren Tugcan Korak Hayal U Simsek Naci Cine N Zafer Canturk N Zafer Utkan Source Type: research

Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer
Clin Cancer Res. 2021 Jun 9:clincanres.0343.2021. doi: 10.1158/1078-0432.CCR-21-0343. Online ahead of print.ABSTRACTPURPOSE: PD-(L)1-targeted therapies have shown modest survival benefit in triple-negative breast cancer (TNBC). PD-L1+ microenvironments in TNBC are not well-characterized and may inform combinatorial immune therapies. Herein, we characterized clinicopathologic features, RNA-based immune signatures and spatially-defined protein-based immune microenvironments (TIME) in early-stage PD-L1+ and PD-L1- TNBC.EXPERIMENTAL DESIGN: From a large cohort of chemotherapy-naïve TNBC, clinicopathologic features, deconv...
Source: Clinical Genitourinary Cancer - June 10, 2021 Category: Cancer & Oncology Authors: Jodi M Carter Mei-Yin C Polley Roberto A Leon-Ferre Jason Sinnwell Kevin J Thompson Xue Wang Yaohua Ma David Zahrieh Jennifer M Kachergus Malvika Solanki Judy C Boughey Minetta C Liu James N Ingle Krishna R Kalari Fergus J Couch E Aubrey Thompson Matthew Source Type: research

A Neoadjuvant Chemotherapy Trial for Early Breast Cancer is Impacted by COVID-19: Addressing Vaccination and Cancer Trials Through Education, Equity, and Outcomes
Clin Cancer Res. 2021 Jun 9:clincanres.1133.2021. doi: 10.1158/1078-0432.CCR-21-1133. Online ahead of print.ABSTRACTWhile COVID-19 vaccine distribution has addressed vulnerabilities related to age and co-morbidities, there is a need to ensure vaccination of cancer patients receiving experimental and routine treatment, where interruption of treatment by infection is likely to result in inferior outcomes. Among cancer patients, those undergoing neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (Adj chemo) for early breast cancer (EBC) are at particularly high risk for inferior outcomes, in part because optimal timing o...
Source: Clinical Genitourinary Cancer - June 10, 2021 Category: Cancer & Oncology Authors: David A Potter Alexandra Thomas Hope S Rugo Source Type: research

Effect of Upadacitinib on the Pharmacokinetics of Rosuvastatin or Atorvastatin in Healthy Subjects
Clin Pharmacol Drug Dev. 2021 Jun 9. doi: 10.1002/cpdd.957. Online ahead of print.ABSTRACTThis phase 1, 2-part, 2-period, open-label, drug-drug interaction study evaluated the potential for pharmacokinetic interactions between upadacitinib and rosuvastatin, an organic anion transporting polypeptide (OATP) 1B1 and breast cancer resistance protein substrate, or atorvastatin, a cytochrome P450 3A, OATP1B1, and OATP1B3 substrate, in 36 healthy volunteers. During period 1, a single dose of rosuvastatin (5 mg; part 1) or atorvastatin (10 mg; part 2) was administered on day 1, followed by a washout period of 5 days. During period...
Source: Clinical Genitourinary Cancer - June 10, 2021 Category: Cancer & Oncology Authors: Mohamed-Eslam F Mohamed Sheryl Coppola Tian Feng Heidi S Camp Elaine Kim Ahmed A Othman Source Type: research

Rates of Ipsilateral Local-regional Recurrence in High-risk Patients Undergoing Immediate Post-mastectomy Reconstruction (AFT-01)
Clin Breast Cancer. 2021 Mar 27:S1526-8209(21)00064-1. doi: 10.1016/j.clbc.2021.03.009. Online ahead of print.ABSTRACTBACKGROUND: Some surgeons remain hesitant to perform immediate breast reconstruction (IBR) in patients with higher risk cancers owing to concerns about cancer recurrence and/or detection. Our objective was to determine the rate of ipsilateral local-regional recurrence for stage II/III patients who underwent IBR.METHODS: The National Cancer Database special study mechanism was used to create a stratified sample of women diagnosed with stage II/III breast cancer from 1217 facilities. Demographic, tumor, and r...
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Christina M Dudley Alyssa A Wiener Trista J Stankowski-Drengler Jessica R Schumacher Amanda B Francescatti Samuel O Poore Caprice C Greenberg Heather B Neuman Source Type: research

Unusual presentation of metastatic radiogenic breast angiosarcoma
Jpn J Clin Oncol. 2021 Jun 9:hyab088. doi: 10.1093/jjco/hyab088. Online ahead of print.NO ABSTRACTPMID:34105728 | DOI:10.1093/jjco/hyab088 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Fabio Carboni Renato Covello Carlo Cota Mario Valle Source Type: research

Patient-centered digital healthcare for patients undergoing breast surgery - A cross-sectional questionnaire study
DISCUSSION: Patients welcome the breast services' website but we need to improve awareness of this resource and include more holistic information, relating not only to their diagnosis and treatment, but practical/support services they can access to make their patient journey smoother.PMID:34105842 | DOI:10.1111/ijcp.14446 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Yuuki Na Karen Hassell Georgette Oni Source Type: research

Management of Women With Breast Cancer and Pathogenic Variants in Genes Other Than BRCA1 or BRCA2
J Clin Oncol. 2021 Jun 9:JCO2100999. doi: 10.1200/JCO.21.00999. Online ahead of print.ABSTRACTThe Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in the Journal of Clinical Oncology, to patients seen in their own clinical practice.PMID:34106763 ...
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Mark Robson Source Type: research

The optimal duration of endocrine therapy in hormone receptor-positive breast cancer
Clin Adv Hematol Oncol. 2021 Jun;19(6):383-404.NO ABSTRACTPMID:34106912 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: George W Sledge Source Type: research

Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers
Clin Pharmacol Drug Dev. 2021 Jun 9. doi: 10.1002/cpdd.961. Online ahead of print.ABSTRACTNapabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase 1. Napabucasin induces cell death in cancer cells, including cancer stem cells. This phase 1 study (NCT03411122) evaluated napabucasin drug-drug interaction potential for 7 cytochrome P450 (CYP) enzymes and the breast cancer resistance protein transporter/organic anion transporter 3. Healthy volunteers who tolerated napabucasin during period 1 r...
Source: Clinical Genitourinary Cancer - June 9, 2021 Category: Cancer & Oncology Authors: Xiaoshu Dai Michael D Karol Matthew Hitron Marjie L Hard Matthew T Goulet Colleen F McLaughlin Scott J Brantley Source Type: research

Breast Density Notification: Current UK National Practice
Clin Breast Cancer. 2021 Jun 4:S1526-8209(21)00113-0. doi: 10.1016/j.clbc.2021.04.013. Online ahead of print.ABSTRACTIncreased breast density is a risk factor for breast cancer and can mask cancer on mammography. This survey attempts to understand clinician views regarding breast density notification in the United Kingdom. Two separate breast density surveys were distributed to radiologists and breast surgeons between May 2019 and May 2020. Invited participants were members of the British Society of Breast Radiology and the Association of Breast Surgeons. We received 232 completed questionnaires from 109 surgeons (71%) and...
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Jajini Varghese Shireen Gohari Fatima Regrag Hirah Rizki Michael Faheem Ahmed Al Naqqash Laura Johnson Serena Ledwidge Jennifer Hu Robert Dickens Mark Wilkinson Louise Jones Tamara Suaris Source Type: research

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score
CONCLUSION: PRS facilitates personalization of BC risk among carriers of PVs in predisposition genes. Incorporating PRS into BC risk estimation may help identify> 30% of CHEK2 and nearly half of ATM carriers below the 20% lifetime risk threshold, suggesting the addition of PRS may prevent overscreening and enable more personalized risk management approaches.PMID:34101481 | DOI:10.1200/JCO.20.01992 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Chi Gao Eric C Polley Steven N Hart Hongyan Huang Chunling Hu Rohan Gnanaolivu Jenna Lilyquist Nicholas J Boddicker Jie Na Christine B Ambrosone Paul L Auer Leslie Bernstein Elizabeth S Burnside A Heather Eliassen Mia M Gaudet Christopher Haiman David J H Source Type: research

FOXA1 overexpression suppresses interferon signaling and immune response in cancer
J Clin Invest. 2021 Jun 8:147025. doi: 10.1172/JCI147025. Online ahead of print.ABSTRACTAndrogen receptor (AR)-positive prostate cancers (PCa) and estrogen receptor (ER)-positive luminal breast cancers (BCa) are generally less responsive to immunotherapy compared to certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated. Here we found that FOXA1 overexpression inversely correlated with interferon (IFN) signature and antigen presentation gene expression in PCa and BCa patients. FOXA1 bound STAT2 DNA binding domain and suppressed STAT2 DNA binding activity, IFN signaling gene expres...
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Yundong He Liguo Wang Ting Wei Yu-Tian Xiao Haoyue Sheng Hengchuan Su Daniel P Hollern Xiaoling Zhang Jian Ma Simeng Wen Hongyan Xie Yuqian Yan Yunqian Pan Xiaonan Hou Xiaojia Tang Vera J Suman Jodi M Carter Richard Weinshilboum Liewei Wang Krishna R Kala Source Type: research

Breast Density Notification: Current UK National Practice
Clin Breast Cancer. 2021 Jun 4:S1526-8209(21)00113-0. doi: 10.1016/j.clbc.2021.04.013. Online ahead of print.ABSTRACTIncreased breast density is a risk factor for breast cancer and can mask cancer on mammography. This survey attempts to understand clinician views regarding breast density notification in the United Kingdom. Two separate breast density surveys were distributed to radiologists and breast surgeons between May 2019 and May 2020. Invited participants were members of the British Society of Breast Radiology and the Association of Breast Surgeons. We received 232 completed questionnaires from 109 surgeons (71%) and...
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Jajini Varghese Shireen Gohari Fatima Regrag Hirah Rizki Michael Faheem Ahmed Al Naqqash Laura Johnson Serena Ledwidge Jennifer Hu Robert Dickens Mark Wilkinson Louise Jones Tamara Suaris Source Type: research

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score
CONCLUSION: PRS facilitates personalization of BC risk among carriers of PVs in predisposition genes. Incorporating PRS into BC risk estimation may help identify> 30% of CHEK2 and nearly half of ATM carriers below the 20% lifetime risk threshold, suggesting the addition of PRS may prevent overscreening and enable more personalized risk management approaches.PMID:34101481 | DOI:10.1200/JCO.20.01992 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Chi Gao Eric C Polley Steven N Hart Hongyan Huang Chunling Hu Rohan Gnanaolivu Jenna Lilyquist Nicholas J Boddicker Jie Na Christine B Ambrosone Paul L Auer Leslie Bernstein Elizabeth S Burnside A Heather Eliassen Mia M Gaudet Christopher Haiman David J H Source Type: research

FOXA1 overexpression suppresses interferon signaling and immune response in cancer
J Clin Invest. 2021 Jun 8:147025. doi: 10.1172/JCI147025. Online ahead of print.ABSTRACTAndrogen receptor (AR)-positive prostate cancers (PCa) and estrogen receptor (ER)-positive luminal breast cancers (BCa) are generally less responsive to immunotherapy compared to certain tumor types such as melanoma. However, the underlying mechanisms are not fully elucidated. Here we found that FOXA1 overexpression inversely correlated with interferon (IFN) signature and antigen presentation gene expression in PCa and BCa patients. FOXA1 bound STAT2 DNA binding domain and suppressed STAT2 DNA binding activity, IFN signaling gene expres...
Source: Clinical Genitourinary Cancer - June 8, 2021 Category: Cancer & Oncology Authors: Yundong He Liguo Wang Ting Wei Yu-Tian Xiao Haoyue Sheng Hengchuan Su Daniel P Hollern Xiaoling Zhang Jian Ma Simeng Wen Hongyan Xie Yuqian Yan Yunqian Pan Xiaonan Hou Xiaojia Tang Vera J Suman Jodi M Carter Richard Weinshilboum Liewei Wang Krishna R Kala Source Type: research

Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131
CONCLUSION: Platinum agents do not improve outcomes in patients with basal subtype TNBC RD post-NAC and are associated with more severe toxicity when compared with capecitabine. Participants had a lower than expected 3-year iDFS regardless of study treatment, highlighting the need for better therapies in this high-risk population.PMID:34092112 | DOI:10.1200/JCO.21.00976 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Ingrid A Mayer Fengmin Zhao Carlos L Arteaga William F Symmans Ben H Park Brian L Burnette Amye J Tevaarwerk Sofia F Garcia Karen L Smith Della F Makower Margaret Block Kimberly A Morley Chirag R Jani Craig Mescher Shabana J Dewani Bernard Tawfik Lisa E F Source Type: research

Radiosensitization using hydrogen peroxide in patients with cervical cancer
Mol Clin Oncol. 2021 Jul;15(1):142. doi: 10.3892/mco.2021.2304. Epub 2021 May 23.ABSTRACTThe purpose of the present study was to analyze the feasibility and safety of radiosensitization using hydrogen peroxide for cervical cancer. In superficial tumors, breast cancer and hepatocellular carcinoma, the safety and effectiveness of radiosensitization has been reported; to the best of our knowledge, however, there are no reports on cervical cancer. A total of 20 patients with cervical cancer were recruited. Inclusion criteria were as follows: Patients who required radical external beam radiotherapy (RT); ineligible for or refus...
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Rong Hu Anneyuko I Saito Taira Mitsuhashi Tatsuya Inoue Tsuyoshi Ota Takafumi Ujihira Koyo Yoshida Keisuke Sasai Source Type: research

Alpelisib-Induced Diabetic Ketoacidosis: A Case Report and Review of Literature
CONCLUSION: Although PI3KCA inhibitors remain a promising drug in patients with metastatic breast cancer who have not responded to previous treatment, patients must be closely monitored for adverse effects such as hyperglycemia. Hyperglycemia could be a potentially limiting side effect of alpelisib. The optimal management of hyperglycemia induced by alpelisib warrants further research.PMID:34095470 | PMC:PMC8053625 | DOI:10.1016/j.aace.2020.11.028 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Maritza Carrillo Renil M Rodriguez Christopher L Walsh Megan Mcgarvey Source Type: research

Translation role of circRNAs in cancers
J Clin Lab Anal. 2021 Jun 7:e23866. doi: 10.1002/jcla.23866. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) constitute a class of covalently closed RNA molecules. With the continuous advancement of high-throughput sequencing technology and bioinformatics tools, many circRNAs have been identified in various human tissues and cell lines. Notably, recent studies have indicated that some circRNAs have translational functions. Internal ribosome entry sites and the N6-methyladenosine modification mediate cap-independent translation. This review describes these two translation mechanisms and verification methods at the mo...
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Yaqin Lu Zhe Li Chen Lin Jian Zhang Zhisen Shen Source Type: research

Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN EA1131
CONCLUSION: Platinum agents do not improve outcomes in patients with basal subtype TNBC RD post-NAC and are associated with more severe toxicity when compared with capecitabine. Participants had a lower than expected 3-year iDFS regardless of study treatment, highlighting the need for better therapies in this high-risk population.PMID:34092112 | DOI:10.1200/JCO.21.00976 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Ingrid A Mayer Fengmin Zhao Carlos L Arteaga William F Symmans Ben H Park Brian L Burnette Amye J Tevaarwerk Sofia F Garcia Karen L Smith Della F Makower Margaret Block Kimberly A Morley Chirag R Jani Craig Mescher Shabana J Dewani Bernard Tawfik Lisa E F Source Type: research

Radiosensitization using hydrogen peroxide in patients with cervical cancer
Mol Clin Oncol. 2021 Jul;15(1):142. doi: 10.3892/mco.2021.2304. Epub 2021 May 23.ABSTRACTThe purpose of the present study was to analyze the feasibility and safety of radiosensitization using hydrogen peroxide for cervical cancer. In superficial tumors, breast cancer and hepatocellular carcinoma, the safety and effectiveness of radiosensitization has been reported; to the best of our knowledge, however, there are no reports on cervical cancer. A total of 20 patients with cervical cancer were recruited. Inclusion criteria were as follows: Patients who required radical external beam radiotherapy (RT); ineligible for or refus...
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Rong Hu Anneyuko I Saito Taira Mitsuhashi Tatsuya Inoue Tsuyoshi Ota Takafumi Ujihira Koyo Yoshida Keisuke Sasai Source Type: research

Alpelisib-Induced Diabetic Ketoacidosis: A Case Report and Review of Literature
CONCLUSION: Although PI3KCA inhibitors remain a promising drug in patients with metastatic breast cancer who have not responded to previous treatment, patients must be closely monitored for adverse effects such as hyperglycemia. Hyperglycemia could be a potentially limiting side effect of alpelisib. The optimal management of hyperglycemia induced by alpelisib warrants further research.PMID:34095470 | PMC:PMC8053625 | DOI:10.1016/j.aace.2020.11.028 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Maritza Carrillo Renil M Rodriguez Christopher L Walsh Megan Mcgarvey Source Type: research

Translation role of circRNAs in cancers
J Clin Lab Anal. 2021 Jun 7:e23866. doi: 10.1002/jcla.23866. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) constitute a class of covalently closed RNA molecules. With the continuous advancement of high-throughput sequencing technology and bioinformatics tools, many circRNAs have been identified in various human tissues and cell lines. Notably, recent studies have indicated that some circRNAs have translational functions. Internal ribosome entry sites and the N6-methyladenosine modification mediate cap-independent translation. This review describes these two translation mechanisms and verification methods at the mo...
Source: Clinical Genitourinary Cancer - June 7, 2021 Category: Cancer & Oncology Authors: Yaqin Lu Zhe Li Chen Lin Jian Zhang Zhisen Shen Source Type: research

Surgical upstaging rates in patients meeting the eligibility for active surveillance trials
CONCLUSIONS: The upstaging rate in patients eligible for the clinical active surveillance trials was 12-25%. Although the rate of upstaging to pT1b or higher was low, further studies are required to determine the rates of upstaging to invasive cancer and the risk factors among patients with low-risk ductal carcinoma in situ.PMID:34091677 | DOI:10.1093/jjco/hyab082 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 6, 2021 Category: Cancer & Oncology Authors: Naoko Iwamoto Miyako Nara Shin-Ichiro Horiguchi Tomoyuki Aruga Source Type: research

Second primary cancers: a retrospective analysis of real world data using the enhanced medical research engine ConSoRe in a French comprehensive cancer center
CONCLUSION: The data mining tool ConSoRe contributes to access to real world data, and to better characterize patients with SPC. Expanding such approach to any comprehensive center will allow a global overview of the follow-up of patients with cancer, and help to improve long-term management and adapt surveillance.PMID:34091824 | DOI:10.1007/s10147-021-01963-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 6, 2021 Category: Cancer & Oncology Authors: Pierre-Etienne Heudel B éatrice Fervers Thierry Durand Sylvie Chabaud Anne-Sophie Michallet Fr édéric Gomez Michel Rivoire Thomas Bachelot Line Claude Catherine Chassagne-Clement Franck Pilleul Thomas Mognetti Bruno Russias Jean-Luc Soubirou Gis èle C Source Type: research

Hypofractionated whole breast irradiation after IORT treatment is safe in patients receiving adjuvant chemotherapy
CONCLUSION: hWBI in high-risk localized breast cancer patients treated by chemotherapy seems to have similar toxicity and cosmetic results than conventionally fractionated WBI in combination to photon-IORT after BCS.PMID:34091868 | DOI:10.1007/s12094-021-02648-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 6, 2021 Category: Cancer & Oncology Authors: J Burgos-Burgos V Vega D Macias-Verde V G ómez M Travieso-Aja J Travieso E Vicente C Murias C Santana J Ospina P C Lara Source Type: research

An Open Source, Automated Tumor Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer
CONCLUSIONS: Neural net driven cell classifier defined TIL variables were robust and independent prognostic factors in several independent validation cohorts of TNBC patients. These objective, open source TIL variables are freely available to download and can now be considered for testing in a prospective setting to assess clinical utility.PMID:34088723 | DOI:10.1158/1078-0432.CCR-21-0325 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2021 Category: Cancer & Oncology Authors: Yalai Bai Kimberly Cole Sandra Martinez-Morilla Fahad Shabbir Ahmed Jon Zugazagoitia Johan Staaf Ana Bosch Anna Ehinger Emma Nim éus Johan Hartman Balazs Acs David L Rimm Source Type: research

Tumor microenvironment in triple-negative breast cancer: the correlation of tumor-associated macrophages and tumor-infiltrating lymphocytes
CONCLUSIONS: Our study suggests that TAMs further create an optimal tumor microenvironment (TME) for growth and invasion of cancer cells when evasion of immunoreactions due to T and B TILs occurs. In TNBCs, all these events combine to affect prognosis. The process of TME is highly complex in TNBCs and for an improved understanding, larger validation studies are necessary to confirm these findings.PMID:34089486 | DOI:10.1007/s12094-021-02652-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2021 Category: Cancer & Oncology Authors: H Kuroda T Jamiyan R Yamaguchi A Kakumoto A Abe O Harada A Masunaga Source Type: research

An Open Source, Automated Tumor Infiltrating Lymphocyte Algorithm for Prognosis in Triple-Negative Breast Cancer
CONCLUSIONS: Neural net driven cell classifier defined TIL variables were robust and independent prognostic factors in several independent validation cohorts of TNBC patients. These objective, open source TIL variables are freely available to download and can now be considered for testing in a prospective setting to assess clinical utility.PMID:34088723 | DOI:10.1158/1078-0432.CCR-21-0325 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2021 Category: Cancer & Oncology Authors: Yalai Bai Kimberly Cole Sandra Martinez-Morilla Fahad Shabbir Ahmed Jon Zugazagoitia Johan Staaf Ana Bosch Anna Ehinger Emma Nim éus Johan Hartman Balazs Acs David L Rimm Source Type: research

Tumor microenvironment in triple-negative breast cancer: the correlation of tumor-associated macrophages and tumor-infiltrating lymphocytes
CONCLUSIONS: Our study suggests that TAMs further create an optimal tumor microenvironment (TME) for growth and invasion of cancer cells when evasion of immunoreactions due to T and B TILs occurs. In TNBCs, all these events combine to affect prognosis. The process of TME is highly complex in TNBCs and for an improved understanding, larger validation studies are necessary to confirm these findings.PMID:34089486 | DOI:10.1007/s12094-021-02652-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 5, 2021 Category: Cancer & Oncology Authors: H Kuroda T Jamiyan R Yamaguchi A Kakumoto A Abe O Harada A Masunaga Source Type: research

Aging and CNS myeloid cell depletion attenuate breast cancer brain metastasis
CONCLUSIONS: Host microenvironmental factors contribute to the aggressiveness of triple-negative and luminal B breast cancer brain metastasis. CSF-1R inhibitors may hold promise for young brain metastasis patients.PMID:34083229 | DOI:10.1158/1078-0432.CCR-21-1549 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Alex Man Lai Wu Selamawit Gossa Ramakrishna Samala Monika A Chung Brunilde Gril Howard Yang Helen R Thorsheim Andy D Tran Debbie Wei Esra Taner Kristine Isanogle Yuan Yang Emma L Dolan Christina M Robinson Simone Difilippantonio Maxwell Lee Imran Khan Que Source Type: research

First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7 (PTK7), in Advanced Solid Tumors
CONCLUSIONS: This PTK7-targeted ADC demonstrated therapeutic activity in previously treated patients with OvCa, NSCLC, and TNBC at a dose range of 2.1-3.2 mg/kg, supporting further clinical evaluation to refine dose, schedule, and predictive tissue biomarker testing in patients with advanced malignancies.PMID:34083232 | DOI:10.1158/1078-0432.CCR-20-3757 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Michael L Maitland Jasgit C Sachdev Manish R Sharma Victor Moreno Valentina Boni Shivaani Kummar Erica Stringer-Reasor Nehal Lakhani Allison R Moreau Dawei Xuan Ruifeng Li Eric L Powell Amy Jackson-Fisher Michelle Bowers Shilpa Alekar Xiaohua Xin Anthony Source Type: research

Increased FNDC5/IRISIN protein expression in breast cancer tissue is associated with obesity in postmenopausal women
J Clin Pathol. 2021 Jun 3:jclinpath-2020-207249. doi: 10.1136/jclinpath-2020-207249. Online ahead of print.ABSTRACTAIM: To analyse the fibronectin type III domain containing 5 (FNDC5)/irisin expression in tumour tissue of postmenopausal women presenting breast cancer and different body mass indexes (BMIs), proposing that obesity deregulates the expression of FNDC5/irisin at the breast tumour level. In addition, we investigated if different breast cancer cell lines are capable to synthesise this protein.METHODS: A total of 150 postmenopausal women (50 with a normal BMI, 50 presenting overweight and 50 having obesity) diagno...
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Mar ía Elena Tejeda Patricia Canto Alberto Tenorio-Torres Letica Orozco-Arguelles Ram ón Mauricio Coral-Vázquez Alejandro Zentella-Dehesa Marcela Leal-Garc ía Claudia Cecilia Vega-Garc ía Ver ónica Bautista-Piña Juan Pablo M éndez Source Type: research

A rare case of lobular breast cancer metastasizing to large bowel
Clin Case Rep. 2021 May 4;9(5):e04081. doi: 10.1002/ccr3.4081. eCollection 2021 May.ABSTRACTLobular breast cancer metastasis to bowel is rare, however, when it occurs, the prognosis is poor. Possible benefits of investigation with screening endoscopy for gastrointestinal metastases are discussed in order to optimize prognosis for patients.PMID:34084499 | PMC:PMC8142465 | DOI:10.1002/ccr3.4081 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Waka Yanagisawa Sandra Krishnan Adrian Fernandez Source Type: research

Primary squamous cell carcinoma of the breast in a young female- A rare ailment
Clin Case Rep. 2021 May 24;9(5):e04214. doi: 10.1002/ccr3.4214. eCollection 2021 May.ABSTRACTPrimary squamous cell carcinoma of the breast is an extremely rare invasive breast carcinoma with rapid progression and worse prognosis. Careful assessment and diagnosis of the entity should also be considered in a rapidly progressing breast tumor.PMID:34084512 | PMC:PMC8142402 | DOI:10.1002/ccr3.4214 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Suraj Shrestha Prafulla Shakya Sanjeev Kharel Hari Prasad Dhakal Moushami Singh Aagon Krishna Shrestha Source Type: research

Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer
CONCLUSION: Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.PMID:34085098 | DOI:10.1007/s00432-021-03670-y (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Wanting Shao Christina Kuhn Doris Mayr Nina Ditsch Magdalena Kailuwait Verena Wolf Nadia Harbeck Sven Mahner Udo Jeschke Vincent Cavaill ès Sophie Sixou Source Type: research

Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C)
CONCLUSION: Using N3C, we assembled the largest nationally representative cohort of patients with cancer and COVID-19 to date. We identified demographic and clinical factors associated with increased all-cause mortality in patients with cancer. Full characterization of the cohort will provide further insights into the effects of COVID-19 on cancer outcomes and the ability to continue specific cancer treatments.PMID:34085538 | DOI:10.1200/JCO.21.01074 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Noha Sharafeldin Benjamin Bates Qianqian Song Vithal Madhira Yao Yan Sharlene Dong Eileen Lee Nathaniel Kuhrt Yu Raymond Shao Feifan Liu Timothy Bergquist Justin Guinney Jing Su Umit Topaloglu Source Type: research

Tissue pharmacokinetics of DHP107, a novel lipid-based oral formulation of paclitaxel, in mice and patients by positron emission tomography
Clin Transl Sci. 2021 Jun 4. doi: 10.1111/cts.13003. Online ahead of print.ABSTRACTDHP107 is a newly developed lipid-based oral formulation of paclitaxel. We evaluated the in vivo tissue pharmacokinetics (PKs) of DHP107 in mice and patients using positron emission tomography (PET). Radioisotope-labeled [3 H]DHP107 and [18 F]DHP107 for oral administration were formulated in the same manner as the manufacturing process of DHP107. In vivo tissue PK were assessed in healthy ICR mice and breast cancer xenografted SCID mice. Two patients with metastatic breast cancer were clinically evaluated for absorption at the target lesion ...
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Byung Seok Moon Hyun Soo Park Jung Sunwoo In-Hyun Lee Anhye Kim Seol Ju Moon Heechan Lee Min Hee Son Su Bin Kim Sun Mi Park Sang-Keun Woo Jun-Hee Jang Bom Sahn Kim Jee Hyun Kim Sang Eun Kim Howard Lee Source Type: research

Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death
CONCLUSION: Adjuvant radiation therapy should be considered in men with pN1 or pGleason score 8 to 10 and pT3/4 PC given the possibility that a significant reduction in ACM risk exists.PMID:34086480 | DOI:10.1200/JCO.20.03714 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Derya Tilki Ming-Hui Chen Jing Wu Hartwig Huland Markus Graefen Thomas Wiegel Dirk B öhmer Osama Mohamad Janet E Cowan Felix Y Feng Peter R Carroll Bruce J Trock Alan W Partin Anthony V D'Amico Source Type: research

Aging and CNS myeloid cell depletion attenuate breast cancer brain metastasis
CONCLUSIONS: Host microenvironmental factors contribute to the aggressiveness of triple-negative and luminal B breast cancer brain metastasis. CSF-1R inhibitors may hold promise for young brain metastasis patients.PMID:34083229 | DOI:10.1158/1078-0432.CCR-21-1549 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Alex Man Lai Wu Selamawit Gossa Ramakrishna Samala Monika A Chung Brunilde Gril Howard Yang Helen R Thorsheim Andy D Tran Debbie Wei Esra Taner Kristine Isanogle Yuan Yang Emma L Dolan Christina M Robinson Simone Difilippantonio Maxwell Lee Imran Khan Que Source Type: research

First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7 (PTK7), in Advanced Solid Tumors
CONCLUSIONS: This PTK7-targeted ADC demonstrated therapeutic activity in previously treated patients with OvCa, NSCLC, and TNBC at a dose range of 2.1-3.2 mg/kg, supporting further clinical evaluation to refine dose, schedule, and predictive tissue biomarker testing in patients with advanced malignancies.PMID:34083232 | DOI:10.1158/1078-0432.CCR-20-3757 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Michael L Maitland Jasgit C Sachdev Manish R Sharma Victor Moreno Valentina Boni Shivaani Kummar Erica Stringer-Reasor Nehal Lakhani Allison R Moreau Dawei Xuan Ruifeng Li Eric L Powell Amy Jackson-Fisher Michelle Bowers Shilpa Alekar Xiaohua Xin Anthony Source Type: research

Increased FNDC5/IRISIN protein expression in breast cancer tissue is associated with obesity in postmenopausal women
J Clin Pathol. 2021 Jun 3:jclinpath-2020-207249. doi: 10.1136/jclinpath-2020-207249. Online ahead of print.ABSTRACTAIM: To analyse the fibronectin type III domain containing 5 (FNDC5)/irisin expression in tumour tissue of postmenopausal women presenting breast cancer and different body mass indexes (BMIs), proposing that obesity deregulates the expression of FNDC5/irisin at the breast tumour level. In addition, we investigated if different breast cancer cell lines are capable to synthesise this protein.METHODS: A total of 150 postmenopausal women (50 with a normal BMI, 50 presenting overweight and 50 having obesity) diagno...
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Mar ía Elena Tejeda Patricia Canto Alberto Tenorio-Torres Letica Orozco-Arguelles Ram ón Mauricio Coral-Vázquez Alejandro Zentella-Dehesa Marcela Leal-Garc ía Claudia Cecilia Vega-Garc ía Ver ónica Bautista-Piña Juan Pablo M éndez Source Type: research

A rare case of lobular breast cancer metastasizing to large bowel
Clin Case Rep. 2021 May 4;9(5):e04081. doi: 10.1002/ccr3.4081. eCollection 2021 May.ABSTRACTLobular breast cancer metastasis to bowel is rare, however, when it occurs, the prognosis is poor. Possible benefits of investigation with screening endoscopy for gastrointestinal metastases are discussed in order to optimize prognosis for patients.PMID:34084499 | PMC:PMC8142465 | DOI:10.1002/ccr3.4081 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Waka Yanagisawa Sandra Krishnan Adrian Fernandez Source Type: research

Primary squamous cell carcinoma of the breast in a young female- A rare ailment
Clin Case Rep. 2021 May 24;9(5):e04214. doi: 10.1002/ccr3.4214. eCollection 2021 May.ABSTRACTPrimary squamous cell carcinoma of the breast is an extremely rare invasive breast carcinoma with rapid progression and worse prognosis. Careful assessment and diagnosis of the entity should also be considered in a rapidly progressing breast tumor.PMID:34084512 | PMC:PMC8142402 | DOI:10.1002/ccr3.4214 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Suraj Shrestha Prafulla Shakya Sanjeev Kharel Hari Prasad Dhakal Moushami Singh Aagon Krishna Shrestha Source Type: research

Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer
CONCLUSION: Altogether, these data suggest that cytoplasmic LXR could be defined as a prognostic marker in early stage primary BC.PMID:34085098 | DOI:10.1007/s00432-021-03670-y (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Wanting Shao Christina Kuhn Doris Mayr Nina Ditsch Magdalena Kailuwait Verena Wolf Nadia Harbeck Sven Mahner Udo Jeschke Vincent Cavaill ès Sophie Sixou Source Type: research

Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C)
CONCLUSION: Using N3C, we assembled the largest nationally representative cohort of patients with cancer and COVID-19 to date. We identified demographic and clinical factors associated with increased all-cause mortality in patients with cancer. Full characterization of the cohort will provide further insights into the effects of COVID-19 on cancer outcomes and the ability to continue specific cancer treatments.PMID:34085538 | DOI:10.1200/JCO.21.01074 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Noha Sharafeldin Benjamin Bates Qianqian Song Vithal Madhira Yao Yan Sharlene Dong Eileen Lee Nathaniel Kuhrt Yu Raymond Shao Feifan Liu Timothy Bergquist Justin Guinney Jing Su Umit Topaloglu Source Type: research

Tissue pharmacokinetics of DHP107, a novel lipid-based oral formulation of paclitaxel, in mice and patients by positron emission tomography
Clin Transl Sci. 2021 Jun 4. doi: 10.1111/cts.13003. Online ahead of print.ABSTRACTDHP107 is a newly developed lipid-based oral formulation of paclitaxel. We evaluated the in vivo tissue pharmacokinetics (PKs) of DHP107 in mice and patients using positron emission tomography (PET). Radioisotope-labeled [3 H]DHP107 and [18 F]DHP107 for oral administration were formulated in the same manner as the manufacturing process of DHP107. In vivo tissue PK were assessed in healthy ICR mice and breast cancer xenografted SCID mice. Two patients with metastatic breast cancer were clinically evaluated for absorption at the target lesion ...
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Byung Seok Moon Hyun Soo Park Jung Sunwoo In-Hyun Lee Anhye Kim Seol Ju Moon Heechan Lee Min Hee Son Su Bin Kim Sun Mi Park Sang-Keun Woo Jun-Hee Jang Bom Sahn Kim Jee Hyun Kim Sang Eun Kim Howard Lee Source Type: research

Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death
CONCLUSION: Adjuvant radiation therapy should be considered in men with pN1 or pGleason score 8 to 10 and pT3/4 PC given the possibility that a significant reduction in ACM risk exists.PMID:34086480 | DOI:10.1200/JCO.20.03714 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 4, 2021 Category: Cancer & Oncology Authors: Derya Tilki Ming-Hui Chen Jing Wu Hartwig Huland Markus Graefen Thomas Wiegel Dirk B öhmer Osama Mohamad Janet E Cowan Felix Y Feng Peter R Carroll Bruce J Trock Alan W Partin Anthony V D'Amico Source Type: research

Management of Breast Cancer Patients During the Coronavirus Disease 2019 Pandemic: The Experience From the Epicenter of China, Wuhan
CONCLUSION: Here, we collected the diagnosis and treatment process of patients with breast cancer in our center during the coronavirus disease 2019 pandemic, which was found to be correlated to a reduction in chemotherapy-related myelosuppression and hepatic dysfunction, hoping to provide a reference for other cancer centers that may suffer from the similar situation.PMID:34078565 | DOI:10.1016/j.clbc.2021.04.014 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 3, 2021 Category: Cancer & Oncology Authors: Jun Zhou Yuyin Liu Ming Xu Li Mei Shengnan Ruan Ning Zhang Pengfei Yi Qianzhi Chen Jie Tan Source Type: research