Cutaneous Angiosarcoma Secondary to Lymphoedema or Radiation Therapy - A Systematic Review.
CONCLUSION: Angiosarcoma in lympedematous upper limbs or after breast cancer irradiation remains uncommon. However, its long latency and high mortality warrant long-term vigilant surveillance. PMID: 30738715 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 6, 2019 Category: Cancer & Oncology Authors: Co M, Lee A, Kwong A Tags: Clin Oncol (R Coll Radiol) Source Type: research
18F-Choline PET/CT in Leptomeningeal Breast Cancer Metastases.
We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2-positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images. PMID: 30516668 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Cuppari L, Reccia P, Burei M, Cervino AR, Evangelista L Tags: Clin Nucl Med Source Type: research
Identifying Cancer-Directed Surgeries in Medicare Claims: A Validation Study Using SEER-Medicare Data.
CONCLUSION: Identifying patients who underwent a cancer-directed surgery from Medicare claims is feasible for many cancer sites, although careful consideration needs to be given to the validity of each site. Our findings support the use of Medicare claims for large-scale quality assessment of cancer surgery by disease site. PMID: 30715928 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Lavery JA, Lipitz-Snyderman A, Li DG, Bach PB, Panageas KS Tags: JCO Clin Cancer Inform Source Type: research
Measures of Treatment Workload for Patients With Breast Cancer.
CONCLUSION: Treatment workload measures capture an important dimension in the experience of patients with cancer. Patients and health care organizations can use workload measures to plan and allocate resources, leading to higher quality and better coordinated care. PMID: 30715929 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Cheng AC, Levy MA Tags: JCO Clin Cancer Inform Source Type: research
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1 α/VEGF signalling in MCF-7 breast cancer cells.
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells. J Exp Clin Cancer Res. 2019 Feb 01;38(1):45 Authors: Ciccone V, Terzuoli E, Donnini S, Giachetti A, Morbidelli L, Ziche M Abstract ᅟ. PMID: 30709378 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Ciccone V, Terzuoli E, Donnini S, Giachetti A, Morbidelli L, Ziche M Tags: J Exp Clin Cancer Res Source Type: research
Breast specimen handling and reporting in the post-neoadjuvant setting: challenges and advances.
Abstract Neoadjuvant systemic therapy is becoming more commonly used in patients with earlier stages of breast cancer. To assess tumour response to neoadjuvant chemotherapy, pathological evaluation is the gold standard. Depending on the treatment response, the pathological examination of these specimens can be quite challenging. However, a uniform approach to evaluate post-neoadjuvant-treated breast specimens has been lacking. Furthermore, there is no single universally accepted or endorsed classification system for assessing treatment response in this setting. Recent initiatives have attempted to create a standar...
Source: Clinical Genitourinary Cancer - January 24, 2019 Category: Cancer & Oncology Authors: Mrkonjic M, Berman HK, Done SJ, Youngson B, Mulligan AM Tags: J Clin Pathol Source Type: research
Which technique of positioning and immobilization is better for breast cancer patients in postmastectomy IMRT, single-pole or double-pole immobilization?
Abstract PURPOSE: Our purpose was to explore which immobilization is more suitable for clinical practice in postmastectomy intensity modulation radiotherapy, the single-pole position or the double-pole position? METHODS: Patients treated with postmastectomy intensity modulation radiotherapy were eligible. They were selected randomly for single-pole position or double-pole position. Dose-volume histogram (DVH) was used to evaluate plans. After their first radiotherapy, the physicians asked a question about the comfort level of their position. The dosimetric parameters, comfort levels, and reproducibility of th...
Source: Clinical Genitourinary Cancer - December 3, 2018 Category: Cancer & Oncology Authors: Xiang Q, Jie W, Zhu K, Wang Q, Cheng J Tags: J Appl Clin Med Phys Source Type: research
[Secondary osteoporosis. Cancer treatment-induced bone loss.]
Abstract Adjuvant aromatase inhibitor therapy for hormone receptor-positive breast cancer in postmenopausal women, and gonadotropin-releasing hormone agonist for prostate cancer in men, are associated with bone loss, leading to the increment of fracture risks. Assessment of bone status, improvement of life style such as diet and exercise, and osteoporosis treatments are essential to keep good bone health in cancer treatment-induced bone loss. PMID: 30487333 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 1, 2018 Category: Cancer & Oncology Authors: Imanishi Y Tags: Clin Calcium Source Type: research
Comparing causes of death of Hodgkin lymphoma and breast cancer patients between medical records and cause-of-death statistics.
Conclusion: Overall, we observed high levels of agreement between CODMR and CODDC for common causes of death in HL and BC patients. Observed discrepancies between CODMR and CODDC frequently occurred in the presence of late effects of treatment for HL. PMID: 30425583 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 15, 2018 Category: Cancer & Oncology Authors: de Vries S, Schaapveld M, Kardaun JW, de Bruin KH, Krol AD, Lugtenburg PJ, Jacobse JN, Aleman BM, van Leeuwen FE Tags: Clin Epidemiol Source Type: research
A primary analysis of a multicenter, prospective, single-arm, confirmatory trial of hypofractionated whole breast irradiation after breast-conserving surgery in Japan: JCOG0906.
Conclusion: Hypofractionated whole breast irradiation is considered to be safe and one of the standard treatments for Japanese women with margin-negative invasive breast cancer after breast-conserving surgery. PMID: 30428042 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Nozaki M, Kagami Y, Shibata T, Nakamura K, Ito Y, Nishimura Y, Kawaguchi Y, Saito Y, Nagata Y, Matsumoto Y, Akimoto T, Hiraoka M, Radiation Therapy Study Group, Japan Clinical Oncology Group Tags: Jpn J Clin Oncol Source Type: research
Abstract Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the PRKAR1A gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of PRKAR1A lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Endocrine manifestations include primary pigmented nodular adrenocortical disease, that may cause Cushing syndrome, growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperpl...
Source: Clinical Genitourinary Cancer - November 14, 2018 Category: Cancer & Oncology Authors: Kamilaris CDC, Faucz FR, Voutetakis A, Stratakis CA Tags: Exp Clin Endocrinol Diabetes Source Type: research
Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.
Abstract The agonistic/antagonistic biocharacter of selective estrogen receptor modulators (SERMs) can have therapeutic advantages, particularly in the case of premenopausal breast cancers. Although the contradictory effects of these modulators have been studied in terms of crosstalk between the estrogen receptor α (ER) and coactivator dynamics and growth factor signaling, the molecular basis of these mechanisms is still obscure. We identify a series of regulatory mechanisms controlling cofactor dynamics on ER and SERM function, whose activities require F-box protein 22 (Fbxo22). Skp1, Cullin1, F-box-contain...
Source: Clinical Genitourinary Cancer - November 12, 2018 Category: Cancer & Oncology Authors: Johmura Y, Maeda I, Suzuki N, Wu W, Goda A, Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T, Akiyama F, Maruyama R, Inoue JI, Furukawa Y, Ohta T, Nakanishi M Tags: J Clin Invest Source Type: research
Effects of serum estradiol and progesterone on estrogen-regulated gene expression in breast cancers of premenopausal patients.
Abstract Background: Expression of estrogen receptor α in breast cancer is essential for estrogen-dependent growth and partially determines the breast cancer subtype. In premenopausal women, expression of estrogen-regulated genes in estrogen receptor-positive breast cancer tissues are reportedly influenced by the menstrual cycle. Methods: We investigated correlations between serum estradiol (E2; tested on the day of surgery) and expression of estrogen-regulated genes and proliferation genes in strongly estrogen receptor α-positive breast cancer tissues from 91 premenopausal women by quantitative r...
Source: Clinical Genitourinary Cancer - November 5, 2018 Category: Cancer & Oncology Authors: Wanifuchi-Endo Y, Asano T, Kondo N, Hato Y, Dong Y, Hisada T, Nishikawa S, Kato H, Takahashi S, Okuda K, Yamashita H, Toyama T Tags: Jpn J Clin Oncol Source Type: research
Serum levels of activins, follistatins and growth factors in neoplasms of the breast: A case-control study.
Conclusions: We showed that members of the IGF-1/IGFBP-4/PAPP-A axis and FSTL-3 may serve as surrogate markers in breast cancer. Future mechanistic and longitudinal studies and/or clinical trials are needed to explore the efficacy of these molecules as non-invasive biomarkers and their possible therapeutic potential in breast cancer. PMID: 30388235 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 1, 2018 Category: Cancer & Oncology Authors: Panagiotou G, Papakonstantinou E, Vagionas A, Polyzos SA, Mantzoros CS Tags: J Clin Endocrinol Metab Source Type: research
Aberrant miRNAs expressed in HER-2 negative breast cancers patient.
CONCLUSION: The miR-200b presents a great potential for the future advancements in the diagnostic/prognostic and therapeutic approach of TNBC, along with other coding or non-coding transcripts. However, this needs to be further integrated in a regulatory network that acts in conjunction with other markers that affect the patients' prognosis or response to therapy. PMID: 30342533 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 20, 2018 Category: Cancer & Oncology Authors: Braicu C, Raduly L, Morar-Bolba G, Cojocneanu R, Jurj A, Pop LA, Pileczki V, Ciocan C, Moldovan A, Irimie A, Eniu A, Achimas-Cadariu P, Paradiso A, Berindan-Neagoe I Tags: J Exp Clin Cancer Res Source Type: research
The concept of the okadaic acid class of tumor promoters is revived in endogenous protein inhibitors of protein phosphatase 2A, SET and CIP2A, in human cancers.
CONCLUSIONS: The overexpression of endogenous protein inhibitors of PP2A, SET and CIP2A, is tightly linked to the progression of various human cancers, as well as Alzheimer's disease. PMID: 30341686 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 20, 2018 Category: Cancer & Oncology Authors: Fujiki H, Sueoka E, Watanabe T, Suganuma M Tags: J Cancer Res Clin Oncol Source Type: research
HIF-2 α promotes conversion to a stem cell phenotype and induces chemoresistance in breast cancer cells by activating Wnt and Notch pathways.
CONCLUSION: In conclusion, HIF-2α promoted stem phenotype conversion and induced resistance to PTX by activating Wnt and Notch pathways. PMID: 30340507 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 19, 2018 Category: Cancer & Oncology Authors: Yan Y, Liu F, Han L, Zhao L, Chen J, Olopade OI, He M, Wei M Tags: J Exp Clin Cancer Res Source Type: research
Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing.
Abstract PURPOSE: To determine the potential for detection of incidental germline cancer predisposition mutations through cell-free DNA (cfDNA) analyses in patients who underwent solid tumor somatic mutation evaluation. PATIENTS AND METHODS: Data were evaluated from 10,888 unselected patients with advanced (stage III/IV) cancer who underwent Guardant360 testing between November 2015 and December 2016. The main outcome was prevalence of putative germline mutations identified among 16 actionable hereditary cancer predisposition genes. RESULTS: More than 50 cancer types were studied, including lung (41%), b...
Source: Clinical Genitourinary Cancer - October 19, 2018 Category: Cancer & Oncology Authors: Slavin TP, Banks KC, Chudova D, Oxnard GR, Odegaard JI, Nagy RJ, Tsang KWK, Neuhausen SL, Gray SW, Cristofanilli M, Rodriguez AA, Bardia A, Leyland-Jones B, Janicek MF, Lilly M, Sonpavde G, Lee CE, Lanman RB, Meric-Bernstam F, Kurzrock R, Weitzel JN Tags: J Clin Oncol Source Type: research
Local cancer recurrence: The realities, challenges, and opportunities for new therapies.
Abstract Locoregional recurrence negatively impacts both long-term survival and quality of life for several malignancies. For appropriate-risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and per...
Source: Clinical Genitourinary Cancer - October 17, 2018 Category: Cancer & Oncology Authors: Mahvi DA, Liu R, Grinstaff MW, Colson YL, Raut CP Tags: CA Cancer J Clin Source Type: research
Negative Association of Proton Pump Inhibitors With Subsequent Development of Breast Cancer: A Nationwide Population-Based Study.
This study used data from the Taiwan National Health Insurance Research Dataset. A total of 64,234 women diagnosed with breast cancer between 2004 and in 2013 were selected as cases. Controls were 64,234 women without cancer who were selected by matching them with cases on the basis of sociodemographic characteristics and widely prevalent comorbidities. Each study subject's claims data were tracked back for 5 years to determine precancer prescriptions of PPIs. Logistic regression modeling was used for the analysis. A total of 11,871 (9.24%) women had used PPIs within the prior 5 years, 8.06% and 10.42% among cases and cont...
Source: Clinical Genitourinary Cancer - October 17, 2018 Category: Cancer & Oncology Authors: Chen CH, Lee CZ, Lin YC, Kao LT, Lin HC Tags: J Clin Pharmacol Source Type: research
AFF3 upregulation mediates tamoxifen resistance in breast cancers.
CONCLUSIONS: These studies establish AFF3 as a key mediator of estrogen-independent growth and tamoxifen resistance and as a potential novel diagnostic and therapeutic target. PMID: 30326937 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 16, 2018 Category: Cancer & Oncology Authors: Shi Y, Zhao Y, Zhang Y, AiErken N, Shao N, Ye R, Lin Y, Wang S Tags: J Exp Clin Cancer Res Source Type: research
Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival.
Abstract Epidemiological studies show a reduced risk of breast cancer (BC) in women consuming high levels of long-chain (LC) omega-3 (ω-3) fatty acids (FAs) compared with women who consumed low levels. However, the regulatory and mechanistic roles of dietary ω-6 and LC-ω-3 FAs on tumor progression, metastasis and survival are poorly understood. Female BALB/c mice (10-week old) were pair-fed with a diet containing ω-3 or an isocaloric, isolipidic ω-6 diet for 16 weeks prior to the orthotopic implantation of 4T1 mammary tumor cells. Major outcomes studied included: mammary tumor growth,...
Source: Clinical Genitourinary Cancer - October 16, 2018 Category: Cancer & Oncology Authors: Khadge S, Thiele GM, Sharp JG, McGuire TR, Klassen LW, Black PN, DiRusso CC, Cook L, Talmadge JE Tags: Clin Exp Metastasis Source Type: research
BCL2L12: a multiply spliced gene with independent prognostic significance in breast cancer.
Abstract Background Alternative splicing is a key process in carcinogenesis and, from a clinical aspect, holds great promises, as alternatively spliced variants have emerged as an untapped source of diagnostic and prognostic markers. Our aim was to assess the prognostic value of three recently recognized splice variants of the apoptosis-related gene, BCL2L12, in breast cancer (BC). Methods Total RNA was extracted from breast samples (150 BC and 80 tumor-adjacent normal tissues) and, following cDNA synthesis, a variant-specific qPCR was performed for the expressional quantification of BCL2L12 v.1, v.2 and v.4 trans...
Source: Clinical Genitourinary Cancer - October 16, 2018 Category: Cancer & Oncology Authors: Kladi-Skandali A, Sideris DC, Scorilas A Tags: Clin Chem Lab Med Source Type: research
Correction to: Current situation of cancer among adolescents and young adults in Japan.
Abstract In the original publication, Tables 4 and 5 have not been published in a readable format. The corrected clear version is given in this Correction. PMID: 30324312 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 15, 2018 Category: Cancer & Oncology Authors: Ohara A, Furui T, Shimizu C, Ozono S, Yamamoto K, Kawai A, Tatara R, Higuchi A, Horibe K Tags: Int J Clin Oncol Source Type: research
Systematic analysis of parameters predicting pathological axillary status (ypN0 vs. ypN+) in patients with breast cancer converting from cN+ to ycN0 through primary systemic therapy (PST).
Kühn T Abstract Optimization of axillary staging among patients converting from clinically node-positive disease to clinically node-negative disease through primary systemic therapy is needed. We aimed at developing a nomogram predicting the probability of positive axillary status after chemotherapy based on clinical/pathological parameters. Patients from study arm C of the SENTINA trial were included. Univariable/multivariable analyses were performed for 13 clinical/pathological parameters to predict a positive pathological axillary status after chemotherapy using logistic regression models. Odds ratios and ...
Source: Clinical Genitourinary Cancer - October 15, 2018 Category: Cancer & Oncology Authors: Liedtke C, Kolberg HC, Kerschke L, Görlich D, Bauerfeind I, Fehm T, Fleige B, Helms G, Lebeau A, Stäbler A, Schmatloch S, Hausschild M, Schwentner L, von Minckwitz G, Loibl S, Untch M, Kühn T Tags: Clin Exp Metastasis Source Type: research
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
CONCLUSION: In current study, we explore the potential effects of Andro in suppressing breast cancer growth and tumor angiogenesis, as well as the precise mechanisms. This work demonstrated the potential anti-cancer effects of Andro, indicating that Andro could inhibit COX-2 expression through attenuating p300 HAT activity and suppress angiogenesis via VEGF pathway, and thereby could be developed as an antitumor agent for the treatment of breast cancer. PMID: 30314513 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 12, 2018 Category: Cancer & Oncology Authors: Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, Zhao X, Feng L, Zhang B, Jin L, Yu F, Ma X, Lv C Tags: J Exp Clin Cancer Res Source Type: research
Correction to: Efficacy of fulvestrant in the treatment of postmenopausal women with endocrine-resistant advanced breast cancer in routine clinical practice.
e;ez NM, Esquerdo G, Ruiz-Borrego M Abstract A sentence under 'Results' heading in the Abstract section was published incorrectly. The correct sentence should read as follows. PMID: 30284231 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 3, 2018 Category: Cancer & Oncology Authors: Blancas I, Fontanillas M, Conde V, Lao J, Martínez E, Sotelo MJ, Jaen A, Bayo JL, Carabantes F, Illarramendi JJ, Gordon MM, Cruz J, García-Palomo A, Mendiola C, Pérez-Ruiz E, Bofill JS, Baena-Cañada JM, Jáñez NM, Esquerdo G, Ruiz-Borrego M Tags: Clin Transl Oncol Source Type: research
Variability and Influencing Factors of QOL in Breast Cancer Patients Having Chemotherapy.
Abstract Variability and factors influencing quality of life (QOL) in breast cancer patients having chemotherapy were examined in a longitudinal prospective cohort study in two teaching hospitals in China. Physical, mental, social/family, and functional QOL changed significantly over time with varying patterns. In addition, various factors influenced the QOL of breast cancer patients at each chemotherapy cycle. Health professionals should focus on critical time periods during chemotherapy, particularly at baseline and during the fourth and fifth cycles when the QOL in our sample was at the lowest point, and they s...
Source: Clinical Genitourinary Cancer - October 3, 2018 Category: Cancer & Oncology Authors: Ai Z, Gao X, Zheng S, Lu C Tags: Clin Nurs Res Source Type: research
A Novel Strategy to Investigate Tissue Secreted Tumor Micro-Environmental Proteins in Serum towards Development of Breast Cancer Early Diagnosis Biomarker Signature.
CONCLUSIONS AND CLINICAL RELEVANCE: GELS, DAPLE, HS90B, A1AT, IQCC and CATD may be promising potential serum biomarker signature for diagnosis of early grade breast cancer. This panel also contributes to better understanding of molecular mechanisms involved in inceptive stage of breast cancer. This article is protected by copyright. All rights reserved. PMID: 30281209 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 3, 2018 Category: Cancer & Oncology Authors: Pendharkar N, Dhali S, Abhang S Tags: Proteomics Clin Appl Source Type: research
Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study.
anMeter JW, Saykin AJ, Ahles T Abstract PURPOSE: To determine treatment and aging-related effects on longitudinal cognitive function in older breast cancer survivors. METHODS: Newly diagnosed nonmetastatic breast cancer survivors (n = 344) and matched controls without cancer (n = 347) 60 years of age and older without dementia or neurologic disease were recruited between August 2010 and December 2015. Data collection occurred during presystemic treatment/control enrollment and at 12 and 24 months through biospecimens; surveys; self-reported Functional Assessment of Cancer Therapy-Cognitive Function; and neuro...
Source: Clinical Genitourinary Cancer - October 3, 2018 Category: Cancer & Oncology Authors: Mandelblatt JS, Small BJ, Luta G, Hurria A, Jim H, McDonald BC, Graham D, Zhou X, Clapp J, Zhai W, Breen E, Carroll JE, Denduluri N, Dilawari A, Extermann M, Isaacs C, Jacobsen PB, Kobayashi LC, Holohan Nudelman K, Root J, Stern RA, Tometich D, Turner R, Tags: J Clin Oncol Source Type: research
Impact of route of administration on genotoxic estrogens concentrations using oral vs. transdermal estradiol in girls with turner syndrome.
Abstract OBJECTIVE: The established link between estrogen and breast cancer occurs via both estrogen receptor (ER)-mediated and non ER-mediated mechanisms. The term genotoxic estrogens describes mutagenic metabolites, including estrogen catechols and quinones, which have been linked to breast carcinogenesis in post-menopausal women. We aimed to assess if the route of administration of 17β estradiol (E2 ) affects the accumulation of genotoxic estrogen metabolites in a model of ovarian failure in young girls with Turner Syndrome. METHODS: Stored plasma samples obtained at 0 and 12 months were used from 40 ...
Source: Clinical Genitourinary Cancer - October 3, 2018 Category: Cancer & Oncology Authors: Mauras N, Torres-Santiago L, Santen R, Mericq V, Ross J, Colon-Otero G, Damaso L, Hossain J, Wang Q, Mesaros C, Blair IA Tags: Clin Endocrinol (Oxf) Source Type: research
Efficacy and Safety of Rivaroxaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation and a History of Cancer: Observations from ROCKET AF.
Abstract Aims: The management of anticoagulation therapy in patients with atrial fibrillation (AF) and cancer is challenging due to increased thrombotic and bleeding risks. We sought to determine the safety and efficacy of rivaroxaban in patients with AF and a history of cancer. Methods and Results: ROCKET AF randomized 14,264 patients with AF to rivaroxaban or warfarin with a median follow-up of 1.9 years. Cox regression models were used to assess the association between cancer history and clinical outcomes, and the relative treatment effect of rivaroxaban versus warfarin in these patients. A total of 640 pa...
Source: Clinical Genitourinary Cancer - September 14, 2018 Category: Cancer & Oncology Authors: Chen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR, Melloni C Tags: Eur Heart J Qual Care Clin Outcomes Source Type: research
Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A 4.5-Year Clinical Experience.
DISCUSSION: MRIgRT is widely applicable within the field of radiation oncology and new clinical uses continue to emerge. At our institution to date, applications such as ART for gastrointestinal cancers and accelerated partial breast irradiation (APBI) for breast cancer have become dominant indications, although this is likely to continue to evolve. PMID: 30197095 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 6, 2018 Category: Cancer & Oncology Authors: Henke LE, Contreras JA, Green OL, Cai B, Kim H, Roach MC, Olsen JR, Fischer-Valuck B, Mullen DF, Kashani R, Thomas MA, Huang J, Zoberi I, Yang D, Rodriguez V, Bradley JD, Robinson CG, Parikh P, Mutic S, Michalski J Tags: Clin Oncol (R Coll Radiol) Source Type: research
Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin.
CONCLUSIONS: Osimertinib is unlikely to have any clinically relevant interaction with CYP3A substrates and has a weak inhibitory effect on BCRP. No new safety concerns were identified in either study. PMID: 30171779 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 1, 2018 Category: Cancer & Oncology Authors: Donald Harvey R, Aransay NR, Isambert N, Lee JS, Arkenau T, Vansteenkiste J, Dickinson PA, Bui K, Weilert D, So K, Thomas K, Vishwanathan K Tags: Br J Clin Pharmacol Source Type: research
Survival Study of Triple-Negative and Non-Triple-Negative Breast Cancer in a Brazilian Cohort.
ra MT Abstract Objective: To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors. Methods: This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated. Results: Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients ...
Source: Clinical Genitourinary Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Gonçalves H, Guerra MR, Duarte Cintra JR, Fayer VA, Brum IV, Bustamante Teixeira MT Tags: Clin Med Insights Oncol Source Type: research
Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: results of the Ulm Birth Cohort Studies.
Abstract BACKGROUND: Soluble CD14 (sCD14) is one of many factors in human breast milk which may influence programming of the immune response in the breastfed child. Though previous studies have mostly found little association between sCD14 concentration in breast milk and atopic outcomes, recent evidence continues to support a role of sCD14 in immune-related disease. OBJECTIVE: We aimed to clarify whether an association exists between sCD14 concentration in human breast milk (m-sCD14) and child atopic dermatitis (AD) diagnosis by age 3 years within the context of two large birth cohorts. METHODS: Data we...
Source: Clinical Genitourinary Cancer - August 7, 2018 Category: Cancer & Oncology Authors: Logan CA, Weiss JM, Koenig W, Stahl B, Carr PR, Brenner H, Rothenbacher D, Genuneit J Tags: Clin Exp Allergy Source Type: research
Evaluation of a Novel Field-placement Algorithm for Locoregional Breast Cancer Radiotherapy Including the Internal Mammary Chain.
This study describes the development and evaluation of such an algorithm. MATERIALS AND METHODS: An algorithm was developed in which six points representing lymph node clinical target volume borders (based on European Society for Radiotherapy and Oncology consensus nodal contouring guidelines) were placed on computed tomography-defined anatomical landmarks and used to place tangential and nodal fields. Single-centre testing in 20 cases assessed the success of the algorithm in covering planning target volumes (PTVs) and adequately sparing organs at risk. Plans derived using the points algorithm were also compared with ...
Source: Clinical Genitourinary Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Ranger A, Dunlop A, Shah P, Amin K, Henderson D, Bartlett FR, Knowles C, Brigden B, Lacey C, Donovan E, Harris E, Kirby AM Tags: Clin Oncol (R Coll Radiol) Source Type: research
Diagnosis of brain metastases in breast cancer patients resulting from neurological symptoms.
CONCLUSIONS: Clinical symptoms and cancer characteristics were correlated with the development of CNSm. Specific risk and protective factors were identified. Among BC patients with neurological symptoms, CNSm should always be considered, especially in patients with certain oncological and clinical features. PMID: 30086430 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Cacho-Díaz B, Spínola-Maroño H, Arrieta VA, Granados-García M, Wegman-Ostrosky T, Mendoza-Olivas LG, Chávez-MacGregor M Tags: Clin Neurol Neurosurg Source Type: research
Effect of denosumab on bone mineral density in Japanese women with osteopenia treated with aromatase inhibitors for breast cancer: subgroup analyses of a Phase II study.
Conclusion: Twice-yearly treatment with denosumab was associated with increased BMD among Japanese women receiving adjuvant AI therapy, regardless of the baseline characteristics or skeletal site. PMID: 30022834 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 21, 2018 Category: Cancer & Oncology Authors: Nakatsukasa K, Koyama H, Ouchi Y, Sakaguchi K, Fujita Y, Matsuda T, Kato M, Konishi E, Taguchi T Tags: Ther Clin Risk Manag Source Type: research
Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
CONCLUSIONS: The ExoCounter system exhibits high performance in the direct detection of exosomes in cell culture and human sera. This method may enable reliable analysis of liquid biopsies. PMID: 30021922 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H Tags: Clin Chem Source Type: research
Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol.
CONCLUSIONS: Our results confirmed a better response of HER2-overexpressing breast cancer to paclitaxel at the miRNA level. One putative reason could be the upregulation of tumor-suppressor miRNAs after treatment with paclitaxel. On the other hand, HER2-negative breast cancer cell lines showed a significantly decreased expression of tumor-suppressor miRNAs, a putative mechanism of resisting the therapy. PMID: 30019863 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Asghari F, Haghnavaz N, Shanehbandi D, Khaze V, Baradaran B, Kazemi T Tags: Adv Clin Exp Med Source Type: research
A randomized, open-label, Phase III trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab and chemotherapy: the Japan Breast Cancer Research Group-M05 PRECIOUS study.
Abstract The PRECIOUS study (UMIN000018202) is being conducted as a multicenter, randomized, open-label Phase III study to determine if retreatment with pertuzumab is more effective than conventional treatment in HER2-positive locally advanced (LA)/metastatic breast cancer (MBC) patients previously treated with pertuzumab, trastuzumab and chemotherapy. Patients are randomized 1:1 into chemotherapy plus trastuzumab with or without pertuzumab groups. The latest regimen before enrollment did not include pertuzumab, and the number of previous chemotherapy regimens for LA/MBC did not exceed three. The primary endpoint ...
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Yamamoto Y, Iwata H, Ueno T, Taira N, Kashiwaba M, Takahashi M, Tada H, Tsugawa K, Toyama T, Niikura N, Hara F, Fujisawa T, Yoshinami T, Saji S, Takano T, Masuda N, Morita S, Toi M, Ohno S Tags: Jpn J Clin Oncol Source Type: research
Management of leptomeningeal metastasis in breast cancer.
Abstract Leptomeningeal metastasis (LM), which occurs when malignant cells spread to the central nervous system, is becoming an increasingly common complication in patients with breast cancer. Diagnosis and treatment of LM is challenging. Moreover, prognosis of patients with LM is poor, with a median survival of 6 months after diagnosis. This review highlights the strengths and limitations of currently available diagnostic tools and therapies for LM. The current treatments for LM, including radiotherapy, systemic therapy, and intrathecal treatment, aim to maintain the quality of life of patients by correcting neur...
Source: Clinical Genitourinary Cancer - July 7, 2018 Category: Cancer & Oncology Authors: Assi HI, Mahmoud T, Saadeh FS, El Darsa H Tags: Clin Neurol Neurosurg Source Type: research
Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer: A case report and review of the literature.
We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor neuron disease. In literature, few cases are reported but no one highlights the tumor receptors' profile. Instead, HER2-positive breast cancers are prone to be related to anti-Yo-associated paraneoplastic cerebellar disorders. Anti-onconeural antibodies positivity can be rarely found, confirming that paraneoplastic MND have no specific biomarkers. The presence of CSF oligoclonal bands (OBs) suggests the presence of immune-mediated mechanism, in absence of other possible OBs causes. PMID: 30007590 [PubM...
Source: Clinical Genitourinary Cancer - July 6, 2018 Category: Cancer & Oncology Authors: Diamanti L, Quaquarini E, Berzero G, Bini P, Gastaldi M, Franciotta D, Alfonsi E, Ceroni M, Frascaroli M, Bernardo A, Marchioni E Tags: Clin Neurol Neurosurg Source Type: research
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer.
Abstract Long non-coding RNAs (lncRNAs), are a novel class of noncoding RNAs, and are commonly defined as RNA molecules greater more than 200 nucleotides in length. Emerging research has indicated that lncRNA played a vital role in the pathophysiology of human tumorigenesis and progression by serving as tumor oncogenes or suppressors either oncogenes or tumor suppressor genes. LncRNA has been shown to get involved in participate various biological processes, such as cell growth, anti-apoptosis, migration and invasion. LncRNA HOXA cluster antisense RNA2 (HOXA-AS2) is a novel cancer-related lncRNA. that It was recen...
Source: Clinical Genitourinary Cancer - July 4, 2018 Category: Cancer & Oncology Authors: Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X, Tai S Tags: Clin Chim Acta Source Type: research
Thoracic paravertebral nerve block for treating contraction of the latissimus dorsi muscle after breast cancer surgery.
PMID: 29980006 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Ueshima H, Otake H Tags: J Clin Anesth Source Type: research
Identification of pathological complete response after neoadjuvant chemotherapy for breast cancer: comparison of greyscale ultrasound, shear wave elastography, and MRI.
CONCLUSIONS: SWE combined with greyscale US shows promise for end-of-treatment identification of response to NACT in women with breast cancer, with accuracies similar to breast MRI. This technique could be used to inform surgical decision-making after NACT. PMID: 29980324 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Evans A, Whelehan P, Thompson A, Purdie C, Jordan L, Macaskill J, Henderson S, Vinnicombe S Tags: Clin Radiol Source Type: research
Ultrasound guided erector spinae plane block reduces postoperative opioid consumption following breast surgery: A randomized controlled study.
Kılıç CT Abstract STUDY OBJECTIVE: To evaluate the analgesic effect of ultrasound-guided erector spinae plane (ESP) block in breast cancer surgery. DESIGN: Randomized controlled, single-blinded trial. SETTING: Operating room. PATIENTS: Fifty ASA I-II patients aged 25-65 and scheduled for elective breast cancer surgery were included in the study. INTERVENTIONS: Patients were randomized into two groups, ESP and control. Single-shot ultrasound (US)-guided ESP block with 20 ml 0.25% bupivacaine at the T4 vertebral level was performed preoperatively to all patients in the ESP group. The c...
Source: Clinical Genitourinary Cancer - July 2, 2018 Category: Cancer & Oncology Authors: Gürkan Y, Aksu C, Kuş A, Yörükoğlu UH, Kılıç CT Tags: J Clin Anesth Source Type: research
Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline.
Abstract Purpose The Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement. Methods The SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep ...
Source: Clinical Genitourinary Cancer - June 11, 2018 Category: Cancer & Oncology Authors: Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, Fouladbakhsh JM, Gil B, Hershman DL, Mansfield S, Mussallem DM, Mustian KM, Price E, Rafte S, Cohen L Tags: J Clin Oncol Source Type: research
Hormone Therapy: Key Points From NAMS 2017 Position Statement.
Abstract The goal of the 2017 North American Menopause Society Hormone Therapy (HT) Position Statement is to remove fear about HT and encourage individualized shared decision making, using best available evidence. Systemic HT is safe and effective for symptomatic menopausal women aged younger than 60 years and within 10 years of menopause. Special populations of early menopause, high risk for fracture, risk of breast or uterine cancer, and extended duration are discussed. With longer duration of use, periodic evaluation and reassessment of health risks are needed. Lowered doses, transdermal therapies or newer opti...
Source: Clinical Genitourinary Cancer - June 8, 2018 Category: Cancer & Oncology Authors: Pinkerton JV Tags: Clin Obstet Gynecol Source Type: research