Endocrine Therapy With or Without CDK4/6 Inhibitors in Women With Hormone-receptor Positive Breast Cancer: What do we Know About the Effects on Cognition?
Clin Breast Cancer. 2021 Aug 14:S1526-8209(21)00239-1. doi: 10.1016/j.clbc.2021.08.002. Online ahead of print.ABSTRACTAdjuvant endocrine therapy (ET) is the cornerstone of treatment for hormone-receptor positive breast cancer. Recently, ET is increasingly combined with "cyclin-dependent kinases 4 and 6'' (CDK4/6) inhibitors. Given the importance of estrogens in neural processes and the role of cyclin D in hippocampal cell proliferation, it is plausible that these therapies affect cognition, but studies on these potential cognitive effects are sparse. In this review, we summarize existing knowledge on the cognitive eff...
Source: Clinical Genitourinary Cancer - September 24, 2021 Category: Cancer & Oncology Authors: Philippe R Lee Meeuw Kjoe Elsken van der Wall Sanne B Schagen Source Type: research

Assessment of mitotic activity in breast cancer: revisited in the digital pathology era
J Clin Pathol. 2021 Sep 23:jclinpath-2021-207742. doi: 10.1136/jclinpath-2021-207742. Online ahead of print.ABSTRACTThe assessment of cell proliferation is a key morphological feature for diagnosing various pathological lesions and predicting their clinical behaviour. Visual assessment of mitotic figures in routine histological sections remains the gold-standard method to evaluate the proliferative activity and grading of cancer. Despite the apparent simplicity of such a well-established method, visual assessment of mitotic figures in breast cancer (BC) remains a challenging task with low concordance among pathologists whi...
Source: Clinical Genitourinary Cancer - September 24, 2021 Category: Cancer & Oncology Authors: Asmaa Ibrahim Ayat Lashen Michael Toss Raluca Mihai Emad Rakha Source Type: research

Dysfunction of miR-802 in tumors
This article reviews the abnormal expression of miR-802 in a variety of tumors, expounds the mechanism by which miR-802 affects tumor progression by regulating different target genes, and elaborates the network of miR-802-related ceRNAs. We also summarized the limitations of miR-802 research and looked forward to the potential application of miR-802 in the diagnosis and prognosis of tumors.PMID:34558723 | DOI:10.1002/jcla.23989 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 24, 2021 Category: Cancer & Oncology Authors: Tong Gao Mengsha Zou Tiancheng Shen Shiwei Duan Source Type: research

PEAK1 promotes invasion and metastasis and confers drug resistance in breast cancer
Clin Exp Med. 2021 Sep 23. doi: 10.1007/s10238-021-00761-5. Online ahead of print.ABSTRACTPseudopodium-enriched atypical kinase 1 (PEAK1) has been reported to be upregulated in human malignancies and is correlated with a poor prognosis. Enhanced PEAK1 expression facilitates tumor cell survival, invasion, metastasis and chemoresistance. However, the role of PEAK1 in breast cancer is unclear. We investigated PEAK1 expression in breast cancer and analyzed the relationship with clinicopathological status and chemotherapy resistance. We also investigated the role of PEAK1 in breast cancer cells in vitro and in vivo. Immunohisto...
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Xingang Wang Yan Zheng Yu Wang Source Type: research

Pharmacodynamic Modeling of CDK4/6 Inhibition Related Biomarkers and the Characterization of the Relationship between Biomarker Response and Progression Free Survival in Patients with Advanced Breast Cancer
This article is protected by copyright. All rights reserved.PMID:34554584 | DOI:10.1002/jcph.1971 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Yanke Yu Wan Sun Yuan Liu Diane Wang Source Type: research

Dosimetric comparison of VitalBeam() and Halcyon(TM) 2.0 for hypofractionated VMAT with simultaneous integrated boost treatment of early-stage left-sided breast cancer
This study compared the quality of treatment plans for early-stage, left-sided breast cancer, as planned for and delivered by the HalcyonTM and VitalBeam® .MATERIALS AND METHODS: Fifteen patients diagnosed with early-stage left-sided breast cancer, who had received VMAT with hypofractionated SIB, were recruited. All cases were planned using HalcyonTM comprising a dual-layer MLC (DL-MLC) and VitalBeam® with a Millennium 120 MLC (VB-MLC). For the PTVs, the quality of coverage (QC), conformity index (CI), and homogeneity index (HI) were calculated for each plan. The dosimetric differences between the two treatment pla...
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Eunbin Ju Eun Jeong Heo Chun Gun Park Minseok Kim Kwang Hyeon Kim Jang Bo Shim Young Je Park Nam Kwon Lee Chul Yong Kim Suk Lee Source Type: research

Critical Appraisal of Adjuvant Platinum-Based Chemotherapy for Basal Subtype Triple-Negative Breast Cancer With Residual Disease After Neoadjuvant Chemotherapy
J Clin Oncol. 2021 Sep 23:JCO2101537. doi: 10.1200/JCO.21.01537. Online ahead of print.NO ABSTRACTPMID:34554822 | DOI:10.1200/JCO.21.01537 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Tatsunori Shimoi Emi Noguchi Kazuki Sudo Yu Jo Chua Kan Yonemori Source Type: research

Reply to T. Shimoi et al and Y. Shimanuki et al
J Clin Oncol. 2021 Sep 23:JCO2101905. doi: 10.1200/JCO.21.01905. Online ahead of print.NO ABSTRACTPMID:34554848 | DOI:10.1200/JCO.21.01905 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Ingrid A Mayer Fengmin Zhao Carlos L Arteaga William F Symmans Ben H Park Brian L Burnette Amye J Tevaarwerk Sofia F Garcia Karen L Smith Della F Makower Margaret Block Kimberly A Morley Chirag R Jani Craig Mescher Shabana J Dewani Bernard Tawfik Lisa E F Source Type: research

Are Platinum Drugs Ineffective for Triple-Negative Breast Cancer With Residual Invasive Disease After Neoadjuvant Chemotherapy?
J Clin Oncol. 2021 Sep 23:JCO2101757. doi: 10.1200/JCO.21.01757. Online ahead of print.NO ABSTRACTPMID:34554850 | DOI:10.1200/JCO.21.01757 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Yumiko Shimanuki Akihiko Shimomura Kenichi Yoshimura Hiroyuki Terakado Chikako Shimizu Source Type: research

Toxicity Index, Patient-Reported Outcomes, and Early Discontinuation of Endocrine Therapy for Breast Cancer Risk Reduction in NRG Oncology/NSABP B-35
J Clin Oncol. 2021 Sep 23:JCO2100910. doi: 10.1200/JCO.21.00910. Online ahead of print.ABSTRACT[Figure: see text].PMID:34554865 | DOI:10.1200/JCO.21.00910 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: N Lynn Henry Sungjin Kim Ron D Hays Marcio A Diniz Michael Luu Reena S Cecchini Greg Yothers Andr é Rogatko Patricia A Ganz Source Type: research

Does Radioactive Iodine Therapy for Hyperthyroidism Cause Cancer?
J Clin Endocrinol Metab. 2021 Sep 23:dgab700. doi: 10.1210/clinem/dgab700. Online ahead of print.ABSTRACTRadioactive iodine has been considered a safe and effective therapeutic option for hyperthyroidism secondary to Graves' disease and autonomously functioning thyroid nodules since the mid-20th century. The question of whether I-131 at the doses used for hyperthyroidism might increase the risk of cancer has been investigated in a number of observational cohort studies over the years, with the preponderance of evidence being reassuring as to its safety. In particular, the 1998 Cooperative Thyrotoxicosis Therapy Follow-up S...
Source: Clinical Genitourinary Cancer - September 23, 2021 Category: Cancer & Oncology Authors: Brian W Kim Source Type: research

Breast Cancer Incidence and Mortality in Relation to Hormone Replacement Therapy Use Among Postmenopausal Women: Results From a Prospective Cohort Study
This study suggests that HRT use was associated with an altered risk of the occurrence of BC in the US postmenopausal women, especially for underweight women.PMID:34548240 | DOI:10.1016/j.clbc.2021.06.010 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Yi Jiang QinLi Xie Rong Chen Source Type: research

Integrated molecular and immune phenotype of HER2-positive breast cancer and response to neoadjuvant therapy: a NeoALTTO exploratory analysis
CONCLUSION: Immuno-phenotyping holds the promise to complement current predictive models in HER2-positive breast cancer and to assist in new therapeutic development.PMID:34548320 | DOI:10.1158/1078-0432.CCR-21-1600 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Sara Pizzamiglio Chiara Maura Ciniselli Tiziana Triulzi Chiara Gargiuli Loris De Cecco Evandro de Azambuja Debora Fumagalli Christos Sotiriou Nadia Harbeck Miguel Izquierdo Paolo Nuciforo Jens Huober Vera Cappelletti Saverio Cinieri Martine Piccart Maria Source Type: research

< em > BRCA1/BRCA2 < /em > variants of uncertain significance in clinical practice: A case report
Mol Clin Oncol. 2021 Nov;15(5):222. doi: 10.3892/mco.2021.2385. Epub 2021 Aug 31.ABSTRACTThe influence of BRCA1/2 variants of uncertain significance (VUSs) on the cancer risk and their association with the response to treatment is uncertain. The aim of the present study was to evaluate the role of BRCA VUS in patients with breast cancer. A total of two cases of breast cancer patients with the BRCA VUS were described. The complete coding sequence of BRCA1/2 genes was analyzed from the genomic DNA material by next generation sequencing on the Ion Torrent platform. The presence of c.3454G>A (p.Asp1152Asn) VUS in the BRCA1 ...
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Joanna Huszno Wojciech Pig łowski Magdalena Mazur Jolanta Pamu ła-Piłat Artur Zajkowicz Anna Fiszer Kierzkowska Ma łgorzata Oczko Wojciechowska Source Type: research

Breast Cancer Incidence and Mortality in Relation to Hormone Replacement Therapy Use Among Postmenopausal Women: Results From a Prospective Cohort Study
This study suggests that HRT use was associated with an altered risk of the occurrence of BC in the US postmenopausal women, especially for underweight women.PMID:34548240 | DOI:10.1016/j.clbc.2021.06.010 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Yi Jiang QinLi Xie Rong Chen Source Type: research

Integrated molecular and immune phenotype of HER2-positive breast cancer and response to neoadjuvant therapy: a NeoALTTO exploratory analysis
CONCLUSION: Immuno-phenotyping holds the promise to complement current predictive models in HER2-positive breast cancer and to assist in new therapeutic development.PMID:34548320 | DOI:10.1158/1078-0432.CCR-21-1600 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Sara Pizzamiglio Chiara Maura Ciniselli Tiziana Triulzi Chiara Gargiuli Loris De Cecco Evandro de Azambuja Debora Fumagalli Christos Sotiriou Nadia Harbeck Miguel Izquierdo Paolo Nuciforo Jens Huober Vera Cappelletti Saverio Cinieri Martine Piccart Maria Source Type: research

< em > BRCA1/BRCA2 < /em > variants of uncertain significance in clinical practice: A case report
Mol Clin Oncol. 2021 Nov;15(5):222. doi: 10.3892/mco.2021.2385. Epub 2021 Aug 31.ABSTRACTThe influence of BRCA1/2 variants of uncertain significance (VUSs) on the cancer risk and their association with the response to treatment is uncertain. The aim of the present study was to evaluate the role of BRCA VUS in patients with breast cancer. A total of two cases of breast cancer patients with the BRCA VUS were described. The complete coding sequence of BRCA1/2 genes was analyzed from the genomic DNA material by next generation sequencing on the Ion Torrent platform. The presence of c.3454G>A (p.Asp1152Asn) VUS in the BRCA1 ...
Source: Clinical Genitourinary Cancer - September 22, 2021 Category: Cancer & Oncology Authors: Joanna Huszno Wojciech Pig łowski Magdalena Mazur Jolanta Pamu ła-Piłat Artur Zajkowicz Anna Fiszer Kierzkowska Ma łgorzata Oczko Wojciechowska Source Type: research

Usefulness of supplementary ultrasound surveillance in the detection of a second breast cancer in patients with ductal carcinoma in situ
CONCLUSION: In DCIS patients, the rate of second breast cancers was 7.5%. Breast conservation, involved margins after lumpectomy and shortened hormonal therapy were associated with second cancers. Patients with involved margins after lumpectomy have the highest cancer detection rate and minimal unnecessary biopsies and follow-ups. Hence, ipsilateral breast ultrasound surveillance could be personalized for this high-risk group with mammographically dense breasts.PMID:34544658 | DOI:10.1016/j.clbc.2021.08.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Hend Saeed Almalki Annabelle Lim John C Allen Sze Yiun Teo Geok Hoon Lim Source Type: research

IL13Ralpha2 promotes proliferation and outgrowth of breast cancer brain metastases
CONCLUSIONS: Non-genomic phenotypic adaptations at metastatic sites are critical to BM progression and patients' prognosis. This study opens the road to use IL13Rα2-targeting as a therapeutic strategy for BM.PMID:34544797 | DOI:10.1158/1078-0432.CCR-21-0361 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: R Alejandro Marquez-Ortiz Maria J Contreras-Zarate Vesna Tesic Karen Lf Alvarez-Eraso Gina Kwak Zachary Littrell James C Costello Varsha Sreekanth D Ryan Ormond Sana D Karam Peter Kabos Diana M Cittelly Source Type: research

Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis
CONCLUSION: Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.PMID:34545638 | DOI:10.1002/jcla.24008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Ramtin Omid-Shafaat Hassan Moayeri Karim Rahimi Mohammad-Nazir Menbari Zakaria Vahabzadeh Mohammad-Saied Hakhamaneshi Bijan Nouri Bayazid Ghaderi Mohammad Abdi Source Type: research

Cancer statistics for the US Hispanic/Latino population, 2021
CA Cancer J Clin. 2021 Sep 21. doi: 10.3322/caac.21695. Online ahead of print.ABSTRACTThe Hispanic/Latino population is the second largest racial/ethnic group in the continental United States and Hawaii, accounting for 18% (60.6 million) of the total population. An additional 3 million Hispanic Americans live in Puerto Rico. Every 3 years, the American Cancer Society reports on cancer occurrence, risk factors, and screening for Hispanic individuals in the United States using the most recent population-based data. An estimated 176,600 new cancer cases and 46,500 cancer deaths will occur among Hispanic individuals in the con...
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Kimberly D Miller Ana P Ortiz Paulo S Pinheiro Priti Bandi Adair Minihan Hannah E Fuchs Dinorah Martinez Tyson Guillermo Tortolero-Luna Stacey A Fedewa Ahmedin M Jemal Rebecca L Siegel Source Type: research

Landscape Analysis of Breast Cancer and Acute Myeloid Leukemia Trials Using the My Cancer Genome Clinical Trial Data Model
CONCLUSION: Analysis and data visualization of the cancer clinical trial landscape can inform strategic planning for new trial designs and trial activation at a particular site.PMID:34546785 | DOI:10.1200/CCI.21.00082 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Neha M Jain Marilyn Holt Christine Micheel Mia Levy Source Type: research

Usefulness of supplementary ultrasound surveillance in the detection of a second breast cancer in patients with ductal carcinoma in situ
CONCLUSION: In DCIS patients, the rate of second breast cancers was 7.5%. Breast conservation, involved margins after lumpectomy and shortened hormonal therapy were associated with second cancers. Patients with involved margins after lumpectomy have the highest cancer detection rate and minimal unnecessary biopsies and follow-ups. Hence, ipsilateral breast ultrasound surveillance could be personalized for this high-risk group with mammographically dense breasts.PMID:34544658 | DOI:10.1016/j.clbc.2021.08.006 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Hend Saeed Almalki Annabelle Lim John C Allen Sze Yiun Teo Geok Hoon Lim Source Type: research

IL13Ralpha2 promotes proliferation and outgrowth of breast cancer brain metastases
CONCLUSIONS: Non-genomic phenotypic adaptations at metastatic sites are critical to BM progression and patients' prognosis. This study opens the road to use IL13Rα2-targeting as a therapeutic strategy for BM.PMID:34544797 | DOI:10.1158/1078-0432.CCR-21-0361 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: R Alejandro Marquez-Ortiz Maria J Contreras-Zarate Vesna Tesic Karen Lf Alvarez-Eraso Gina Kwak Zachary Littrell James C Costello Varsha Sreekanth D Ryan Ormond Sana D Karam Peter Kabos Diana M Cittelly Source Type: research

Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis
CONCLUSION: Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.PMID:34545638 | DOI:10.1002/jcla.24008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Ramtin Omid-Shafaat Hassan Moayeri Karim Rahimi Mohammad-Nazir Menbari Zakaria Vahabzadeh Mohammad-Saied Hakhamaneshi Bijan Nouri Bayazid Ghaderi Mohammad Abdi Source Type: research

Cancer statistics for the US Hispanic/Latino population, 2021
CA Cancer J Clin. 2021 Sep 21. doi: 10.3322/caac.21695. Online ahead of print.ABSTRACTThe Hispanic/Latino population is the second largest racial/ethnic group in the continental United States and Hawaii, accounting for 18% (60.6 million) of the total population. An additional 3 million Hispanic Americans live in Puerto Rico. Every 3 years, the American Cancer Society reports on cancer occurrence, risk factors, and screening for Hispanic individuals in the United States using the most recent population-based data. An estimated 176,600 new cancer cases and 46,500 cancer deaths will occur among Hispanic individuals in the con...
Source: Clinical Genitourinary Cancer - September 21, 2021 Category: Cancer & Oncology Authors: Kimberly D Miller Ana P Ortiz Paulo S Pinheiro Priti Bandi Adair Minihan Hannah E Fuchs Dinorah Martinez Tyson Guillermo Tortolero-Luna Stacey A Fedewa Ahmedin M Jemal Rebecca L Siegel Source Type: research

Patients' awareness about their own breast cancer characteristics
CONCLUSION: Breast cancer patients in China know little about their disease, and better education aimed at improving their knowledge about cancer characteristics is urgently needed. The low level of awareness could represent a deficiency of communication between surgeons and patients, which may be one of the reasons why medical disputes occur in China.PMID:34540959 | PMC:PMC8409217 | DOI:10.12998/wjcc.v9.i24.7043 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 20, 2021 Category: Cancer & Oncology Authors: Chong Geng Guo-Jun Lu Jing Zhu Yu-Yang Li Source Type: research

Elemental Concentration in the Biological Samples of Pakistani Male Breast Cancer Patients
Clin Lab. 2021 Sep 1;67(9). doi: 10.7754/Clin.Lab.2021.201223.ABSTRACTBACKGROUND: Breast cancer is an uncommon (rare) disease in men, approximately 1% of the total breast cancer cases in the world. By reason of the rare occurrence, there is no clinical or hospital study giving the information about the essential trace and toxic elements in the biological samples of male breast cancer patients.METHODS: The aim of current study was to estimate association among essential trace {zinc (Zn), iron (Fe) and copper (Cu)} and toxic {cadmium (Cd) and lead (Pb)} elements in human biological samples particularly blood, serum, scalp ha...
Source: Clinical Genitourinary Cancer - September 20, 2021 Category: Cancer & Oncology Authors: Hassan I Afridi Ghulam Q Chanihoon Tasneem G Kazi Farah N Talpur Jameel A Baig Ghulam M Channa Source Type: research

Region of interest optimization for radiation therapy of breast cancer
J Appl Clin Med Phys. 2021 Sep 20. doi: 10.1002/acm2.13410. Online ahead of print.ABSTRACTPURPOSE: The goal of this study was to investigate how the choice of the region of interest (ROI) affects the registration results of surface imaging for daily positioning of breast cancer patients.METHODS: The AlignRT system (VisionRT, London) and the XVI Cone beam CT (CBCT; Elekta, Stockholm) installed on two Versa HD linacs (Elekta) were used in this study, which included 28 patients (160 fractions). In the clinical workflow, patients were prepositioned with AlignRT and then shifted in 6 degrees of freedom (DOF) according to the CB...
Source: Clinical Genitourinary Cancer - September 20, 2021 Category: Cancer & Oncology Authors: Tim-Oliver Sauer Oliver J Ott Godehard Lahmer Rainer Fietkau Christoph Bert Source Type: research

Screening mammography mitigates breast cancer disparities through early detection of triple negative breast cancer
Clin Imaging. 2021 Aug 30;80:430-437. doi: 10.1016/j.clinimag.2021.08.013. Online ahead of print.ABSTRACTPURPOSE: Screening mammography improves breast cancer survival through early detection, but Triple Negative Breast Cancer (TNBC) is more difficult to detect on mammography and has lower survival compared to non-TNBC, even when detected at early stages. TNBC is twice as common among African American (AA) compared to White American (WA) women, thereby contributing to the 40% higher breast cancer mortality rates observed in AA women. The role of screening mammography in addressing breast cancer disparities is therefore wor...
Source: Clinical Genitourinary Cancer - September 20, 2021 Category: Cancer & Oncology Authors: Solange Bayard Genevieve Fasano Yalei Chen Melissa Davis Michele Drotman Jennifer Bensenhaver Alexander Swistel Rache Simmons Jennifer Marti Lisa Newman Source Type: research

Breast Surgery: Management of Postoperative Complications Following Operations for Breast Cancer
Surg Clin North Am. 2021 Oct;101(5):845-863. doi: 10.1016/j.suc.2021.06.014. Epub 2021 Aug 7.ABSTRACTBreast cancer surgery is associated with low rates of surgical morbidity. Postoperative complications related to breast surgery include seroma, infection, hematoma, mastectomy flap necrosis, wound dehiscence, persistent postsurgical pain, Mondor disease, fat necrosis, reduced tactile sensation after mastectomy, and venous thromboembolism. Postoperative complications related to axillary surgery include seroma, infection, lymphedema, nerve injury, and reduced shoulder/arm mobility. The overall rate of complication related to ...
Source: Clinical Genitourinary Cancer - September 19, 2021 Category: Cancer & Oncology Authors: Zahraa Al-Hilli Avia Wilkerson Source Type: research

circRNA-miRNA-mRNA in breast cancer
This article reviews recent research progress on the circRNA-miRNA-mRNA axis as a regulatory network of competing endogenous RNAs in breast cancer. Herein, we focus on the mechanism and function of the circRNA-miRNA-mRNA axis in the occurrence and metastasis of breast cancer, and resistance to chemotherapy.PMID:34537217 | DOI:10.1016/j.cca.2021.09.013 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 19, 2021 Category: Cancer & Oncology Authors: Meilan Zhang Xue Bai Xuemei Zeng Jiangrong Liu Feng Liu Zhiwei Zhang Source Type: research

DISCO App: study protocol for a randomized controlled trial to test the effectiveness of a patient intervention to reduce the financial burden of cancer in a diverse patient population
Trials. 2021 Sep 17;22(1):636. doi: 10.1186/s13063-021-05593-y.ABSTRACTBACKGROUND: Financial toxicity, the material and psychological burden of the cost of treatment, affects 30-50% of people with cancer, even those with health insurance. The burden of treatment cost can affect treatment adherence and, ultimately, mortality. Financial toxicity is a health equity issue, disproportionately affecting patients who are racial/ethnic minorities, have lower incomes, and are
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Lauren M Hamel David W Dougherty Seongho Kim Elisabeth I Heath Lorna Mabunda Eyouab Tadesse RaeAnn Hill Susan Eggly Source Type: research

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance
CONCLUSIONS: Hence, our work has provided significant insights into our understanding of 3D-growth-specific chromatin architecture in tamoxifen-resistant breast cancer. Our analyses suggest that the strengthened looping-mediated Hippo relevant pathways may contribute to endocrine therapy resistance in breast cancer patients.PMID:34535185 | PMC:PMC8447690 | DOI:10.1186/s13148-021-01167-6 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Jingwei Li Kun Fang Lavanya Choppavarapu Ke Yang Yini Yang Junbai Wang Ruifeng Cao Ismail Jatoi Victor X Jin Source Type: research

The Ultrasonographic Characteristics of Focal Fibrocystic Change of the Breast and Analysis of Misdiagnosis
CONCLUSION: FC frequently exhibits low heterogeneity, scattered microcapsules with posterior enhancement, "pit-like" or "grid-like" changes, posterior enhancement, rare hyperechoic halo, calcification, and lack of blood supply. Certain focal FC are irregularly shaped with unclear edges, with malignant signs such as crab feet and burr, hyperechoic halo, and calcification, which ultrasound BI-RADS classification may easily misdiagnose as malignant. Local magnification function should be considered, and the internal structure should be carefully observed to prevent misdiagnosis.PMID:34535389 | DOI:10.1016/...
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Xueying Lin Yimi He Shiwei Fu Si Lin Ensheng Xue Liwu Lin Source Type: research

Radix Tetrastigma Extracts Enhance the Chemosensitivity in Triple-Negative Breast Cancer Via Inhibiting PI3K/Akt/mTOR-Mediated Autophagy
CONCLUSION: RTEs enhanced the chemosensitivity of resistant TNBC cells to Taxol through inhibiting PI3K/Akt/mTOR-mediated autophagy.MICRO: RTEs exerted anti-tumor effects in various cancers, and this study determined its role in TNBC. Taxol-resistant MDA-MB-468 cells were induced and xenograft models were established. We found that RTEs inhibited autophagy of MDA-MB-468/Taxol cells and reduced tumor growth. Inhibition of PI3K/Akt/mTOR pathway promoted autophagy of MDA-MB-468/Taxol cells. We may provide a new potential strategy for TNBC treatment.PMID:34535390 | DOI:10.1016/j.clbc.2021.07.015 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Shuo Zhang Tongxing Cui Yin Duan Hongchen Zhang Bei Wang Huiling Chen Junjie Ni Yilin Shen None Xiao-Ai Lv Source Type: research

Combined Complete Decongestive Therapy Reduces Volume and Improves Quality of Life and Functional Status in Patients With Breast Cancer-Related Lymphedema
Clin Breast Cancer. 2021 Aug 19:S1526-8209(21)00242-1. doi: 10.1016/j.clbc.2021.08.005. Online ahead of print.ABSTRACTBACKGROUND: The aim of this study was to evaluate the effects of complete decongestive therapy (CDT) in patients with breast cancer-related lymphedema (BCRL), in regard to volume reduction, functional status and quality of life (QoL).METHODS: Fifty patients with unilateral BCRL were included. The demographic variables focusing on lymphedema were recorded. All patients received combined phase 1 CDT including skin-care, manual lymphatic drainage, multilayer bandaging and supervised exercises, 5 times a week f...
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: P ınar Borman Ay şegül Yaman Sina Yasrebi Adeviye P ınar İnanlı Ay şe Arıkan Dönmez Source Type: research

Menopausal hormone therapy and breast cancer risk
Best Pract Res Clin Endocrinol Metab. 2021 Sep 10:101577. doi: 10.1016/j.beem.2021.101577. Online ahead of print.ABSTRACTThis narrative review analyses the customization of Menopause Hormone Therapy in the context of breast cancer risk in women with premature ovarian insufficiency (POI) and with menopause at a normal age. Women with Idiopathic POI, FMR-1 premutation or Turner syndrome, if left untreated, may have lower breast cancer risk compared to the healthy age-matched female population. These women should be treated with MHT until the age of 50, as the risk of breast cancer is equal to that of normally menstruating wo...
Source: Clinical Genitourinary Cancer - September 18, 2021 Category: Cancer & Oncology Authors: Serge Rozenberg Victoria Di Pietrantonio Jean Vandromme Christine Gilles Source Type: research

Breast Cancer Navigation: Using Physician and Patient Surveys to Explore Nurse Navigator Program Experiences
This study aimed to understand patient and physician experiences with a breast cancer navigation (BCN) program using Lean design principles.METHODS: Surveys were developed and distributed from 2019 to 2020 to 255 patients diagnosed with breast cancer and 128 physicians in primary care and cancer-related specialties. Descriptive analyses were conducted.FINDINGS: Eighty-three physicians and 94 patients completed the survey. A large majority of physicians reported that the BCN program "made their day easier" and improved flow, care coordination, and patient experience. A large majority of patients reported receiving...
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Ellis C Dillon Paul Kim Martina Li Qiwen Huang Natalia Colocci Cynthia Cantril Dorothy Y Hung Source Type: research

Pre-Appointment Nurse Navigation: Patient-Centered Findings From a Survey of Patients With Breast Cancer
This study attempted to elucidate the efficacy of nurse navigation in patient knowledge, care coordination, and well-being before a breast oncology appointment.METHODS: Staff provided a nine-question survey to 50 newly referred patients before their initial appointment. After survey completion, patients had the option to participate in an open-ended interview about their experience.FINDINGS: A greater proportion of patients with initial nurse navigation than those without felt informed before their appointment and thought that their care was effectively coordinated. Although some patients without nurse navigation experienc...
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Tianyi Wang Yash S Huilgol Janet Black Carrie D'Andrea Jennifer James Anna Northrop Jeff Belkora Laura J Esserman Source Type: research

Rural Cancer Disparities: Understanding Implications for Breast and Cervical Cancer Diagnoses
This study seeks to identify structural-, community-, and individual-level barriers that affect rural populations across the cancer continuum, understand the role of nurses serving rural populations in breast and cervical cancer screening and diagnostics, and provide recommendations for working with rural patients.METHODS: This is a secondary analysis of qualitative interviews conducted with public health nurses serving rural populations.FINDINGS: Emergent themes indicate that rural populations experience barriers that affect disparities across the breast and cervical cancer continuum, including a changing healthcare lands...
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Leslie R Carnahan Randa Abdelrahim Carol E Ferrans Genevieve R Rizzo Yamile Molina Arden Handler Source Type: research

Cardio-Oncology Health Disparities: Social Determinants of Health and Care for Black Breast Cancer Survivors
This article discusses the role of SDOH in cardio-oncology and strategies to prevent and detect adverse cardiovascular outcomes among Black breast cancer survivors.METHODS: Preliminary case study findings are presented, including treatment exposures to cardiotoxicity and SDOH in cardio-oncology influencing health outcomes in Black breast cancer survivors.FINDINGS: Nurses can address SDOH and racial disparities in cardio-oncology by being mindful of Black breast cancer survivors' increased burden of CVD risk factors, evaluating barriers to receive preventive care and cardio-oncology rehabilitation, practicing cultural humil...
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Lakeshia Cousin Natalee Roper Timiya S Nolan Source Type: research

Dietary insulin index and load with risk of breast cancer in a case-control study
CONCLUSIONS: Our findings suggest that a diet that induces an elevated postprandial insulin response, indicated by higher DII and DIL scores, may increase the odds of BrCa, especially among women.PMID:34534393 | DOI:10.1111/ijcp.14883 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Atieh Akbari Mohammad Hassan Sohouli Oana Deliu Ozovanu Mojtaba Lotfi Raheleh Nabavizadeh Reza Saeidi Source Type: research

Use of non-contrast MR in diagnosing secondary lymphedema of the upper extremities
Clin Imaging. 2021 Sep 10;80:400-405. doi: 10.1016/j.clinimag.2021.08.018. Online ahead of print.ABSTRACTPURPOSE: The purpose of the study is to determine if a combination of dermal thickening and subcutaneous fluid honeycombing on non-contrast MRI, termed the dermal rim sign (DRS), can be diagnostically analogous to dermal backflow seen on lymphoscintigraphy in patients with secondary upper extremity lymphedema.MATERIALS AND METHODS: Upper extremity MRI and lymphoscintigraphy were performed on patients referred to a multidisciplinary lymphedema clinic for suspicion of secondary lymphedema. Sensitivity, specificity, and po...
Source: Clinical Genitourinary Cancer - September 17, 2021 Category: Cancer & Oncology Authors: Geunwon Kim Kevin Donohoe Martin P Smith Ryoko Hamaguchi Anna Rose Johnson Dhruv Singhal Leo L Tsai Source Type: research

Clinical Impact of COVID-19 Outbreak on Cancer Patients: A Retrospective Study
CONCLUSIONS: COVID-19 diagnosis in cancer patients may affect their short-term OS, especially in case of interruption/starting failure of cancer therapy. Maintaining/delaying cancer therapy seems not to influence the outcome in selected patients with recent COVID-19 diagnosis.PMID:34526833 | PMC:PMC8436296 | DOI:10.1177/11795549211043427 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 16, 2021 Category: Cancer & Oncology Authors: Sebastiano Buti Fabiana Perrone Teresa Zielli Giulia Mazzaschi Chiara Casartelli Alessandro Leonetti Gianluca Milanese Mario Silva Roberta Eufrasia Ledda Antonino Musolino Francesca Pucci Melissa Bersanelli Marcello Tiseo Source Type: research

An Analysis of Electronic Health Record Work to Manage Asynchronous Clinical Messages among Breast Cancer Care Teams
CONCLUSION: At our institution, clinical messaging occurred in 35% of all EHR sessions. Clinical messaging, sometimes viewed as a supporting task of clinical work, is important to delivering and coordinating care across roles. Measuring the electronic work of asynchronous communication among care team members affords the opportunity to systematically identify opportunities to improve employee workload.PMID:34528233 | PMC:PMC8443401 | DOI:10.1055/s-0041-1735257 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 16, 2021 Category: Cancer & Oncology Authors: Bryan D Steitz Kim M Unertl Mia A Levy Source Type: research

Identification of a six-microRNA signature as a potential diagnostic biomarker in breast cancer tissues
CONCLUSION: We showed that the dysregulation of a novel signature of six-miRNA can be used as a potential biomarker for BC diagnosis.PMID:34528314 | DOI:10.1002/jcla.24010 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 16, 2021 Category: Cancer & Oncology Authors: Mojdeh Mahmoudian Ehsan Razmara Bashdar Mahmud Hussen Mandana Simiyari Nazanin Lotfizadeh Hoda Motaghed Arefeh Khazraei Monfared Maryam Montazeri Sadegh Babashah Source Type: research

Recalibrating the decision for MRI-directed breast ultrasound in patients with newly diagnosed breast cancer, factors predicting sonographic success
Clin Imaging. 2021 Sep 7;80:391-399. doi: 10.1016/j.clinimag.2021.08.022. Online ahead of print.ABSTRACTOBJECTIVE: Evaluate utilization of MRI-directed breast ultrasound (US) in patients with newly diagnosed breast cancer and refine practices to increase success of sonographic lesion detection.METHODS: This retrospective single-institution review was restricted to women with breast cancer who underwent MRI from November 2006 to January 2017. Enhancing breast lesions, separate from the index tumor, recommended for MRI-directed US were assessed to see which were detected and which characteristics predicted success in detecti...
Source: Clinical Genitourinary Cancer - September 16, 2021 Category: Cancer & Oncology Authors: Santo Maimone Andrey P Morozov Zhuo Li Emily C Craver Erin A Elder Sarah A McLaughlin Source Type: research

Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial
Clin Cancer Res. 2021 Sep 14:clincanres.1562.2021. doi: 10.1158/1078-0432.CCR-21-1562. Online ahead of print.ABSTRACTPURPOSE: Serum Thymidine Kinase 1 (sTK1) activity is associated with poor prognosis in metastatic breast cancer (MBC). We assessed the prognostic effect of sTK1 in patients with hormone receptor-positive MBC treated on a prospective randomized trial of anastrozole (A) vs. A plus fulvestrant (A+F).EXPERIMENTAL DESIGN: sTK1 was assessed in 1,726 serums [baseline (BL), cycles 2, 3, 4, and 7] using the DiviTum® assay. A pre-specified cutoff of {greater than or equal to}200 Du/L was considered high. Progressi...
Source: Clinical Genitourinary Cancer - September 15, 2021 Category: Cancer & Oncology Authors: Costanza Paoletti William E Barlow Erin F Cobain Mattias Bergqvist Rita S Mehta Julie R Gralow Gabriel N Hortobagyi Kathy S Albain Lajos Pusztai Priyanka Sharma Andrew K Godwin Alastair M Thompson Daniel F Hayes James M Rae Source Type: research

Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial
Clin Cancer Res. 2021 Sep 14:clincanres.1562.2021. doi: 10.1158/1078-0432.CCR-21-1562. Online ahead of print.ABSTRACTPURPOSE: Serum Thymidine Kinase 1 (sTK1) activity is associated with poor prognosis in metastatic breast cancer (MBC). We assessed the prognostic effect of sTK1 in patients with hormone receptor-positive MBC treated on a prospective randomized trial of anastrozole (A) vs. A plus fulvestrant (A+F).EXPERIMENTAL DESIGN: sTK1 was assessed in 1,726 serums [baseline (BL), cycles 2, 3, 4, and 7] using the DiviTum® assay. A pre-specified cutoff of {greater than or equal to}200 Du/L was considered high. Progressi...
Source: Clinical Genitourinary Cancer - September 15, 2021 Category: Cancer & Oncology Authors: Costanza Paoletti William E Barlow Erin F Cobain Mattias Bergqvist Rita S Mehta Julie R Gralow Gabriel N Hortobagyi Kathy S Albain Lajos Pusztai Priyanka Sharma Andrew K Godwin Alastair M Thompson Daniel F Hayes James M Rae Source Type: research