Dynamic biomarkers indicate the immunological benefits provided by Ganoderma spore powder in post-operative breast and lung cancer patients.
CONCLUSIONS: Our findings show that T lymphocyte subsets combined with relevant cytokines and AGR/NLR inflammatory predictors may help to identify patients most likely to benefit from the immunological enhancements from G. lucidum treatment. PMID: 33405051 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 6, 2021 Category: Cancer & Oncology Authors: Deng Y, Ma J, Tang D, Zhang Q Tags: Clin Transl Oncol Source Type: research

Feasibility of level II oncoplastic techniques in the surgical management of locally advanced breast cancer after neoadjuvant treatment.
CONCLUSION: It should be noted that the responses to NAC increased with targeted therapies, and breast-conserving became possible in a substantial number of patients who were not eligible for breast-conserving surgery at the first presentation. Notably, oncoplastic surgery increased breast conservation rates without compromising oncological results. PMID: 33406297 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 6, 2021 Category: Cancer & Oncology Authors: Gulcelik MA, Doğan L Tags: Int J Clin Pract Source Type: research

Prescribing patterns in breast cancer survivors: A Korean National Health Insurance Service cohort study.
This study aimed to investigate the prescription patterns of drugs prescribed frequently among breast cancer survivors and to provide data to monitor adverse effects using other covariates in these patients. MATERIALS AND METHODS: We analyzed a Korean national sample cohort database. The diagnosis of breast cancer, survival, survival duration, and frequency of drug prescription were first defined and extracted. We then analyzed the frequency of drug prescription in breast cancer by survival duration. Factors associated with drug prescribing patterns were analyzed using logistic regression analysis. RESULTS: Among...
Source: Clinical Genitourinary Cancer - January 5, 2021 Category: Cancer & Oncology Authors: Oh HS, Chan A, Seo HJ Tags: Int J Clin Pharmacol Ther Source Type: research

Incidence of bone metastases in patients with organ-specific cancers: a nationwide population-based cohort study.
CONCLUSION: The estimated BM incidence provided insight into oncological clinical practice trends in the Asia-Pacific region. BM incidence may vary among populations. Understanding the principles of clinical evaluation in patients with cancer of unknown primary origin can facilitate appropriate treatment recommendations. PMID: 33400307 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 5, 2021 Category: Cancer & Oncology Authors: Shih JT, Yeh TT, Wang SH, Shen PH, Wang CC, Chien WC, Chung CH, Wu CC Tags: Int J Clin Pract Source Type: research

An unusual case of longstanding mammary Paget's disease presenting with reticulated skin changes.
Abstract A Caucasian female presented initially at the age of 84 with a 20-year history of an erythematous, reticular plaque over her left areola with a large cutaneous horn. Over the preceding years, the rash slowly spread and became mildly pruritic. Previous topical treatments included emollients and hydrocortisone cream which had little beneficial effect. There was no personal or family history of breast cancer. PMID: 33400312 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 5, 2021 Category: Cancer & Oncology Authors: Dhariwal S, Rytina E, Sterling J Tags: Clin Exp Dermatol Source Type: research

Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T cell exclusion.
CONCLUSION: These results demonstrate that PGRN promotes M2 polarization and PD-L1 expression by activating the STAT3 signaling pathway. Furthermore, through PD-1/PD-L1 interaction, PGRN can promote the breast tumor immune escape. Our research may provide new ideas and targets for clinical breast cancer immunotherapy. PMID: 33390170 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 4, 2021 Category: Cancer & Oncology Authors: Fang W, Zhou T, Shi H, Yao M, Zhang D, Qian H, Zeng Q, Wang Y, Jin F, Chai C, Chen T Tags: J Exp Clin Cancer Res Source Type: research

Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation.
Abstract The success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. CD8+ T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is central to this process. In this issue of the JCI, Fang, Wang, et al. describe a unique tumor immunoevasion strategy based on endocytosis and degradation of MHC-I complexes mediated by the trafficking factor MAL2. Notably, MAL2 expression was associated with poor prognosis of breast cancer, and its downregulation enhanced CD8+ T cell recognition of breast cancer in various experimental models. This...
Source: Clinical Genitourinary Cancer - January 4, 2021 Category: Cancer & Oncology Authors: Dersh D, Yewdell JW Tags: J Clin Invest Source Type: research

A Set of Markers Related to Viral-Infection Has a Sex-sensitive Prognostic Value in Papillary Thyroid Carcinoma.
CONCLUSION: In this study, we searched all publicly available microarray datasets and conducted a comprehensive analysis to understand the male propensity for higher malignancy. We found that, markers of viral infection showed significantly differential expression only in male patients as compared to their female counterparts and had a sex-sensitive prognostic value in PTC. PMID: 33395461 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 4, 2021 Category: Cancer & Oncology Authors: Wan D, Yang X, Li G, Du Y, Cao J, Gao Y, Shu Z, Zhou Y, Wei X, Guo R, Zhang R, Zhang G Tags: J Clin Endocrinol Metab Source Type: research

Life-threatening airway obstruction caused by angioedema in a morbidly obese postoperative patient: a case report.
CONCLUSIONS: Angioedema induced by angiotensin-converting enzyme (ACE) inhibitors is rare; however, once it occurs, it can be potentially life threatening, especially for patients with possible difficult airway. Considering the risk-benefit ratio, we must be careful in administering ACE inhibitor therapy in morbidly obese patients. PMID: 33398469 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 4, 2021 Category: Cancer & Oncology Authors: Konda M, Inoue S, Naito Y, Egawa J, Kawaguchi M Tags: JA Clin Rep Source Type: research

Modeling breast cancer survival and metastasis rates from moderate-sized clinical data.
Abstract Predicting time-dependent survival probability of a breast cancer patient using information such as primary tumor size, grade, node spread status, and patient age at the time of surgery can be of immense help in managing life expectations and strategizing postoperative treatment. However, for moderate-sized clinical datasets the application of standard Kaplan-Meier theory to determine survival probability as a function of multiple cofactors can become challenging when continuous variables like tumor diameter and survival time are segmented into a large number of narrow intervals, a problem commonly termed...
Source: Clinical Genitourinary Cancer - January 3, 2021 Category: Cancer & Oncology Authors: Maiti E Tags: Clin Exp Metastasis Source Type: research

DDAB cationic lipid-mPEG, PCL copolymer hybrid nano-carrier synthesis and application for delivery of siRNA targeting IGF-1R into breast cancer cells.
Abstract BACKGROUND AND OBJECTIVE: To use siRNA molecule as a therapeutic agent in gene silencing, an efficient delivery system is necessary. Stability and clearance by reticuloendothelial of siRNA still remains the major challenges for clinical application. Herein, we could develop new lipid-polymer hybrid nanoparticles (LPHNP) as a siRNA carrier to silence insulin-like growth factor type I (IGF-1R) gene overexpression in MCF-7 human breast cancer cell line. METHODS: Dimethyldioctadecylammonium bromide-methoxy poly(ethylene glycol)-poly (ε-caprolactone) (DDAB-mPEG-PCL) LPHNPs were synthesized using a...
Source: Clinical Genitourinary Cancer - January 3, 2021 Category: Cancer & Oncology Authors: Khodaei M, Rostamizadeh K, Taromchi AH, Monirinasab H, Fathi M Tags: Clin Transl Oncol Source Type: research

Comparing hypofractionated and conventionally fractionated whole breast irradiation for patients with ductal carcinoma in situ after breast conservation: a propensity score-matched analysis from a national multicenter cohort (COBCG-02 study).
CONCLUSION: A short course of radiation therapy seems to be comparable to CF-WBI in terms of clinical outcomes. These data support the use of hypofractionated schedules in DCIS patients, but considering the remaining uncertainties. PMID: 33387035 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 2, 2021 Category: Cancer & Oncology Authors: De Rose F, De Santis MC, Meduri B, Franzese C, Franceschini D, Franco P, Pasinetti N, Lancellotta V, Giacobazzi P, La Rocca E, D'Angelo E, Lozza L, Livi L, Meattini I, Scorsetti M Tags: J Cancer Res Clin Oncol Source Type: research

The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan.
CONCLUSIONS: This investigation provides reference data for the application of precision oncology in a clinical setting. Further investigations on the standardization of clinical annotations are warranted. PMID: 33385275 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - January 1, 2021 Category: Cancer & Oncology Authors: Sunami K, Naito Y, Aimono E, Amano T, Ennishi D, Kage H, Kanai M, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Yoshino T Tags: Int J Clin Oncol Source Type: research

Pituitary Metastases Discovered by 18F-FDG PET/CT During Other Cancers Monitoring: Are There Any Differences of SUVs Between Benign and Malignant Diseases?
We present the case of a 46-year-old woman with breast cancer metastasis in her pituitary. We analyzed 10,347 FDG PET/CT examinations from a tertiary center, finding 4 cases (0.038%) of pituitary metastatic disease from other cancers. We analyzed the differences between SUVmax in cases of physiological high uptake, primary tumor, and hypophysis metastases from other cancers in our database compared with the literature. PMID: 33031239 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 31, 2020 Category: Cancer & Oncology Authors: Piciu A, Mester A, Piciu D Tags: Clin Nucl Med Source Type: research

Rare Thyroid Cartilage Metastasis From Breast Cancer Visualized on 18F-NaF PET/CT.
We present the case of a 65-year-old woman recently diagnosed with breast cancer referred for skeletal staging with F-NaF PET/CT. She was found to have multiple osteoblastic metastases along with thyroid cartilage metastasis. Rare thyroid cartilage metastasis on F-NaF PET/CT may have prognostic significance in cancer patients. PMID: 33156044 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 31, 2020 Category: Cancer & Oncology Authors: Usmani S, Ahmed N, Ilyas MW, Murad S, Al Kandari F Tags: Clin Nucl Med Source Type: research

Relationship between MUTYH, OGG1 and BRCA1 mutations and mRNA expression in breast and ovarian cancer predisposition.
Abstract The aetiology of breast and ovarian cancer (BC/OC) is multi-factorial. At present, the involvement of base excision repair (BER) glycosylases (MUTYH and OGG1) in BC/OC predisposition is controversial. The present study investigated whether germline mutation status and mRNA expression of two BER genes, MUTHY and OGG1, were correlated with BRCA1 in 59 patients with BC/OC and 50 matched population controls. In addition, to evaluate the relationship between MUTYH, OGG1 and BRCA1, their possible mutual modulation and correlation among mutational spectrum, gene expression and demographic characteristics were ev...
Source: Clinical Genitourinary Cancer - December 23, 2020 Category: Cancer & Oncology Authors: Moscatello C, Di Nicola M, Veschi S, Di Gregorio P, Cianchetti E, Stuppia L, Battista P, Cama A, Curia MC, Aceto GM Tags: Mol Clin Oncol Source Type: research

Adherence to the three Italian screening in a sample of women (and men) in the Southern Italy.
CONCLUSIONS: the study carried out found that despite the knowledge of the oncological disease and the possibilities of prevention is fairly rooted in the population, adherence to the screening is quite inadequate, especially as regards colorectal cancer. PMID: 33346333 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 23, 2020 Category: Cancer & Oncology Authors: Genovese C, Squeri R, Alessi V, Conti A, D'Amato S, Mazzitelli F, Costa G, Squeri A Tags: Clin Ter Source Type: research

Prolactin and Estrogen Levels in Postmenopausal Women Receiving Aripiprazole Augmentation Treatment for Depression.
CONCLUSIONS: Aripiprazole addition to an antidepressant did not alter serum estrogens or prolactin. These findings may be relevant in the treatment of some postmenopausal women with depression. PMID: 33347020 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 23, 2020 Category: Cancer & Oncology Authors: Rahman T, Patrick C, Ma C, Nicol GE, Reynolds CF, Mulsant BH, Hartz SM, Yingling M, Lenze EJ Tags: J Clin Psychopharmacol Source Type: research

Hypophosphatemia and FGF23 tumor-induced osteomalacia in two cases of metastatic breast cancer.
Abstract Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by factor-induced dysregulation of phosphate and vitamin D metabolism resulting in alterations in bone formation, leading to bone pain and fractures. While the true incidence is likely underestimated, less than 500 cases of TIO have been reported since initial description in 1947. TIO cases have classically been associated with mesenchymal tumors of bone and soft tissue, but have also rarely been linked to malignant tumors, with scant reports implicating non-mesenchymal tumors. TIO is mediated through inappropriate tumor over...
Source: Clinical Genitourinary Cancer - November 16, 2020 Category: Cancer & Oncology Authors: Abramson M, Glezerman IG, Srinivasan M, Ross R, Flombaum C, Gutgarts V Tags: Clin Nephrol Source Type: research

The Role of Hedgehog Pathway in Female Cancers.
Conclusions: The hedgehog pathway was shown to be activated in several types of female cancers. Therefore, targeting HH pathway may be considered as a therapeutic option to be acknowledged in the treatment of female cancers. PMID: 33179013 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 14, 2020 Category: Cancer & Oncology Authors: Garcia N, Ulin M, Al-Hendy A, Yang Q Tags: J Cancer Sci Clin Ther Source Type: research

Platelet activation in situ in breasts at high risk of cancer: relationship with mammographic density and estradiol.
CONCLUSIONS: Breast density, not estradiol, is the major determinant of local platelet activation. Inactivation of platelets may be a therapeutic strategy for cancer prevention in postmenopausal women with dense breasts. PMID: 33180937 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 13, 2020 Category: Cancer & Oncology Authors: Mijic S, Dabrosin C Tags: J Clin Endocrinol Metab Source Type: research

Electrochemotherapy of skin metastases from breast cancer: a systematic review.
Abstract Skin metastases occur in 5-30% of breast cancer (BC) patients. Standard treatments include systemic therapies (chemotherapy, endocrine therapy, and immunotherapy) and local treatments (surgery and radiotherapy). Electrochemotherapy (ECT) could be another option in this setting based on preclinical and clinical studies. Aim of this review was to analyze the available evidence on ECT in skin metastases from BC. Studies reporting on ECT in skin metastases from BC were included in this review. Studies not reporting toxicity or tumor response or not reporting results separately from other primary cancers were ...
Source: Clinical Genitourinary Cancer - November 12, 2020 Category: Cancer & Oncology Authors: Ferioli M, Perrone AM, Buwenge M, Arcelli A, Zamagni A, Macchia G, Deodato F, Cilla S, Tagliaferri L, De Terlizzi F, De Iaco P, Zamagni C, Morganti AG Tags: Clin Exp Metastasis Source Type: research

Primary mucinous cystadenocarcinoma of the breast: a clinicopathologic analysis of one case and review of the literature.
CONCLUSIONS: MCA is a rare primary breast cancer and strikingly similar to ovarian, pancreatic and gastrointestinal counterparts. The diagnosis cannot be made until the metastatic lesion is ruled out. On the other hand, the biologic behavior of MCA is reportedly favorable despite a high proliferation index and triple negative biomarker status. Therefore, the role of adjuvant chemotherapy or radiation is questionable. PMID: 33165376 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Wang X, Li Y, Zhao P, Jia H, Dong X, Zhang L, Wang C Tags: Int J Clin Exp Pathol Source Type: research

Overexpression of EPDR1 has an antitumorigenic effect on breast cancer in vitro.
CONCLUSION: EPDR1 inhibited malignant behaviors and promoted apoptosis in breast cancer cells by activation of the p53 signaling pathway. PMID: 33165408 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Liang X, Bai J, Chen B Tags: Int J Clin Exp Pathol Source Type: research

Long noncoding RNA PDIA3P promotes breast cancer development by regulating miR-183/ITGB1/FAK/PI3K/AKT/ β-catenin signals [Retraction].
Long noncoding RNA PDIA3P promotes breast cancer development by regulating miR-183/ITGB1/FAK/PI3K/AKT/β-catenin signals [Retraction]. Int J Clin Exp Pathol. 2020;13(10):2718 Authors: Abstract [This retracts the article on p. 1284 in vol. 12, PMID: 31933942.]. PMID: 33165410 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 11, 2020 Category: Cancer & Oncology Tags: Int J Clin Exp Pathol Source Type: research

Long non-coding RNA MAFG-AS1 knockdown blocks malignant progression in breast cancer cells by inactivating JAK2/STAT3 signaling pathway via MAFG-AS1/miR-3196/TFAP2A axis.
CONCLUSION: MAFG-AS1 knockdown attenuated breast cancer progression in vitro and in vivo through activation of the JAK2/STAT3 signaling pathway by the MAFG-AS1/miR-3196/TFAP2A regulatory axis. PMID: 33165437 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Ding M, Fu Y, Guo F, Chen H, Fu X, Tan W, Zhang H Tags: Int J Clin Exp Pathol Source Type: research

Tumorigenesis-related key genes in adolescents and young adults with HR(+)/HER2(-) breast cancer.
Abstract Breast cancer (BC) in adolescents and young adults (AYAs) accounts for 5.6% of BC in all women. BC in this population is often characterized as aggressive. Two-thirds of BC in AYAs belong to the hormone-receptor positive (HR(+))/human epidermal growth factor receptor 2 negative (HER2(-)) subtype. However, the underlying pathogenesis of this subtype has not been fully elucidated. To study HR(+)/HER2(-) BC in AYAs, we downloaded the available RNA-seq data from The Cancer Genome Atlas (TCGA) database and then performed differential expression gene screening and constructed a protein-protein interaction (PPI)...
Source: Clinical Genitourinary Cancer - November 11, 2020 Category: Cancer & Oncology Authors: Yi S, Zhou W Tags: Int J Clin Exp Pathol Source Type: research

Real-world experience of palbociclib and ribociclib: novel oral therapy in metastatic breast cancer.
Conclusion Palbociclib and ribociclib outcomes are comparable to those reached in the phase III trials, PALOMA-3 and MONALEESA-2, respectively, and cannot be compared as they were used in different treatment settings. The toxicity profile is favourable, being neutropenia the most common adverse event, easily managed with regimen changes. Further studies are needed to confirm the observed tendency of no detrimental impact on effectiveness of these regimen changes. PMID: 33170404 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 10, 2020 Category: Cancer & Oncology Authors: García-Trevijano Cabetas M, Lucena Martínez P, Jiménez Nácher I, Díaz Almirón M, Zamora Auñón P, Herrero Ambrosio A Tags: Int J Clin Pharm Source Type: research

Optimizing antiemetic treatment for chemotherapy-induced nausea and vomiting in Japan: Update summary of the 2015  Japan Society of Clinical Oncology Clinical Practice Guidelines for Antiemesis.
Optimizing antiemetic treatment for chemotherapy-induced nausea and vomiting in Japan: Update summary of the 2015  Japan Society of Clinical Oncology Clinical Practice Guidelines for Antiemesis. Int J Clin Oncol. 2020 Nov 08;: Authors: Aogi K, Takeuchi H, Saeki T, Aiba K, Tamura K, Iino K, Imamura CK, Okita K, Kagami Y, Tanaka R, Nakagawa K, Fujii H, Boku N, Wada M, Akechi T, Iihara H, Ohtani S, Okuyama A, Ozawa K, Kim YI, Sasaki H, Shima Y, Takeda M, Nagasaki E, Nishidate T, Higashi T, Hirata K Abstract Patients with cancer should appropriately receive antiemetic therapies against chemotherapy-i...
Source: Clinical Genitourinary Cancer - November 8, 2020 Category: Cancer & Oncology Authors: Aogi K, Takeuchi H, Saeki T, Aiba K, Tamura K, Iino K, Imamura CK, Okita K, Kagami Y, Tanaka R, Nakagawa K, Fujii H, Boku N, Wada M, Akechi T, Iihara H, Ohtani S, Okuyama A, Ozawa K, Kim YI, Sasaki H, Shima Y, Takeda M, Nagasaki E, Nishidate T, Higashi T, Tags: Int J Clin Oncol Source Type: research

A Validation of Methods for the Evaluation of Observational Studies of Screening Mammography: An Exploratory Analysis Based on Simulating Screening Cohorts.
Conclusion: There is no single ideal method to analyze observational data to evaluate the effectiveness of screening mammography (ie, which generates an unbiased estimates of the underlying hazard ratio) but designs which emulate randomised trials should be promoted. PMID: 33149693 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 7, 2020 Category: Cancer & Oncology Authors: Giannakeas V, Sopik V, Narod S Tags: Clin Epidemiol Source Type: research

Neuroendocrine tumours of the breast: a genomic comparison with mucinous breast cancers and neuroendocrine tumours of other anatomic sites.
CONCLUSIONS: Breast NETs are heterogeneous and are characterised by an enrichment of mutations in transcription factors and likely constitute a spectrum of entities histologically and genomically related to MuBCs. While most breast NETs are distinct from ER-positive/HER2-negative IDC-NSTs, a subset of breast NETs appears to be genetically similar to common forms of ER-positive breast cancer, suggesting that some breast cancers may acquire neuroendocrine differentiation later in tumour evolution. PMID: 33148628 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Pareja F, Vahdatinia M, Marchio C, Lee SSK, Da Cruz Paula A, Derakhshan F, da Silva EM, Selenica P, Dopeso H, Chandarlapaty S, Wen HY, Vincent-Salomon A, Brogi E, Weigelt B, Reis-Filho JS Tags: J Clin Pathol Source Type: research

Early diagnosis of breast cancer from exhaled breath by gas chromatography-mass spectrometry (GC/MS) analysis: A prospective cohort study.
CONCLUSIONS: This set of seven breast cancer-specific VOCs can be regarded as one particular expiratory marker for DCIS and will help to establish new screening methods for early breast cancer. PMID: 33150682 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Zhang Y, Guo L, Qiu Z, Lv Y, Chen G, Li E Tags: J Clin Lab Anal Source Type: research

Feasibility and safety of breast-conserving surgery via a periareolar incision for cancers located far from the nipple-areolar complex: a retrospective study.
CONCLUSION: For cancers located far from the NAC, BCS via periareolar incisions is feasible and leads to superior cosmesis in selective patients. Moreover, BCS seems oncologically safe, although long-term outcomes need to be evaluated. PMID: 33146759 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Woo J, Lee J, Paek SH, Lim W Tags: J Cancer Res Clin Oncol Source Type: research

Persistent urinary phosphate wasting in a  patient with metastatic breast cancer: What's your diagnosis?
We report a case of TIO in a patient with metastatic breast cancer complicated by increased parathyroid hormone release secondary to denosumab-induced hypocalcemia. The patient required intensive intravenous and oral phosphate supplementation in addition to vitamin D repletion. A high index of clinical suspicion can yield the correct diagnosis where TIO arises in the setting of a solid organ tumor and help the clinician appropriately manage these challenging cases. PMID: 33141014 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 3, 2020 Category: Cancer & Oncology Authors: Bhasin B, Velez JCQ Tags: Clin Nephrol Source Type: research

Beyond premature ovarian insufficiency: Staging reproductive aging in adolescent and young adult cancer survivors.
CONCLUSIONS: We demonstrate a novel association between gonadotoxic treatments and advanced stages of reproductive aging. Without endocrine biomarkers, bleeding pattern alone can misclassify AYA survivors into either more or less advanced stages. Moreover, a large proportion of AYA survivors exhibited combinations of endocrine biomarkers and bleeding patterns that do not fit STRAW+10 criteria, suggesting the need for modified staging for this population. PMID: 33141175 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 3, 2020 Category: Cancer & Oncology Authors: Medica ACO, Whitcomb BW, Shliakhsitsava K, Dietz A, Pinson K, Lam C, Romero SAD, Sluss P, Sammel MD, Su HI Tags: J Clin Endocrinol Metab Source Type: research

A review on age-related cancer risks in PTEN Hamartoma Tumor Syndrome.
This article is protected by copyright. All rights reserved. PMID: 33140411 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 2, 2020 Category: Cancer & Oncology Authors: Hendricks LAJ, Hoogerbrugge N, Schuurs-Hoeijmakers JHM, Vos JR Tags: Clin Genet Source Type: research

Impact of sex hormones dysregulation and adiposity on the outcome of postmenopausal breast cancer patients.
Abstract Epidemiological studies demonstrated that, in postmenopausal women, high circulating levels of testosterone, especially when associated with weight gain, positively correlated with an increased risk of breast cancer because of the augmented production of oestrogen via testosterone aromatization in the adipose tissue. Besides, growing evidence suggests that sulfatase can increase the tissue concentration of bioactive estradiol through the reconversion of estrone sulfate, thus providing a favourable milieu for epithelial cells expressing the oestrogen receptor. In this review, we will discuss how the "...
Source: Clinical Genitourinary Cancer - November 1, 2020 Category: Cancer & Oncology Authors: Coradini D, Oriana S Tags: Clin Obes Source Type: research

Optimizing care for younger women with hormone receptor-positive, HER2-negative metastatic breast cancer.
Abstract Treatment strategies for hormone receptor-positive (HR+ ), human epidermal growth factor receptor 2-negative (HER2- ) metastatic breast cancer in young women (
Source: Clinical Genitourinary Cancer - November 1, 2020 Category: Cancer & Oncology Authors: de Boer R, Hui R, Lim E, Yeo B, Zdenkowski N Tags: Asia Pac J Clin Oncol Source Type: research

Breast Cancer Detection and Treatment Monitoring Using a Noninvasive Prenatal Testing Platform: Utility in Pregnant and Nonpregnant Populations.
CONCLUSIONS: The results underscore the potential of NIPT-based tests, analyzing CNAs in plasma cfDNA in a genome-wide and unbiased fashion for breast cancer detection, cancer subtyping and treatment monitoring in a pregnant and nonpregnant target population. PMID: 33141904 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 1, 2020 Category: Cancer & Oncology Authors: Lenaerts L, Che H, Brison N, Neofytou M, Jatsenko T, Lefrère H, Maggen C, Villela D, Verheecke M, Dehaspe L, Croitor A, Hatse S, Wildiers H, Neven P, Vandecaveye V, Floris G, Vermeesch JR, Amant F Tags: Clin Chem Source Type: research

PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane.
CONCLUSIONS: IHC of single proteins or heatmap subgroups of the differentially activated PI3K/MAPK pathways was not able to discriminate patients on EVE/EXE with poor or better PFS. Upregulation of p-4EBP1 in pre-treatment biopsies as compared to levels in primary tumours pointed towards shorter PFS. PMID: 32566979 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Kruger DT, Opdam M, van der Noort V, Sanders J, Nieuwenhuis M, de Valk B, Beelen KJ, Linn SC, Boven E Tags: J Cancer Res Clin Oncol Source Type: research

Sensitivity to differential NRF1 gene signatures contributes to breast cancer disparities.
CONCLUSION: Our findings showed how sensitivity to high NRF1 transcriptional activity coupled with its target gene signatures contribute to racial differences in luminal A and TN breast cancer subtypes. This knowledge may be useful in personalized intervention to prevent and treat this clinically challenging problem. PMID: 32705365 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Ramos J, Yoo C, Felty Q, Gong Z, Liuzzi JP, Poppiti R, Thakur IS, Goel R, Vaid AK, Komotar RJ, Ehtesham NZ, Hasnain SE, Roy D Tags: J Cancer Res Clin Oncol Source Type: research

Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres.
CONCLUSION: The combination of niclosamide and temozolomide effectively decreased the stemness and invasive properties of GBM TSs, suggesting that this regimen may be therapeutically effective in treating patients with GBM. PMID: 32712753 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Oh HC, Shim JK, Park J, Lee JH, Choi RJ, Kim NH, Kim HS, Moon JH, Kim EH, Chang JH, Yook JI, Kang SG Tags: J Cancer Res Clin Oncol Source Type: research

Concerns about the economics of mammography and how radiologists can respond.
Abstract Rapidly increasing U.S. healthcare spending has been a hot topic over the past few decades. Imaging studies, including screening mammography, are possible targets for cost savings. Radiologists need to be more proactive and take charge by actively participating in the cost reduction conversation, improving the quality of care, providing patients with accurate cost estimates and educating patients along with clinicians on the value we have provided and can provide in the future. PMID: 32460152 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Chang Sen LQ, Mayo RC, Leung JWT Tags: Clin Imaging Source Type: research

Performance of screening MRI in high risk patients at initial versus subsequent screen.
Abstract PURPOSE: To compare the characteristics, outcomes, and performance metrics in women undergoing initial breast MRI screening versus subsequent screening. METHODS: A retrospective database search identified screening MRIs performed at an academic practice from 2013 to 2015. MRIs were divided into two groups: (1) initial screens and (2) subsequent screens (interpreted with at least one prior MRI for comparison). Benignity was confirmed with pathology or>1-year follow-up. Malignancy was confirmed by pathology. Performance metrics were calculated. Comparisons were made using Binomial and Fisher's exact...
Source: Clinical Genitourinary Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Hayward JH, Ray KM, Price ER, Sickles EA, Conlon K, Lobach I, Joe BN, Lee AY Tags: Clin Imaging Source Type: research

Thyroid isthmus agenesis and its clinical significance in a large-scale multidetector CT-based study.
CONCLUSION: Thyroid isthmus agenesis is not a rare developmental anomaly of the thyroid gland on multi-detector CT. Based on the metastatic pathophysiology of differentiated thyroid cancer, more extended indications for lobectomy are expected in differentiated thyroid cancer patients with thyroid isthmus agenesis. PMID: 32470707 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Kim SK, Seo HS, Lee YH, Son GS, Suh SI Tags: Clin Imaging Source Type: research

"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses.
"The unusual suspects"-Mammographic, sonographic, and histopathologic appearance of atypical breast masses. Clin Imaging. 2020 Oct;66:111-120 Authors: Naeem M, Zulfiqar M, Ballard DH, Billadello L, Cao G, Winter A, Lowdermilk M Abstract Breast malignancy is the second most common cause of cancer death in women. However, less common breast masses can mimic carcinoma and can pose diagnostic challenges. This case-based review describes a spectrum of rare breast neoplastic and non-neoplastic masses ranging from malignant to benign entities. Malignant masses in this review include adenoid cystic ...
Source: Clinical Genitourinary Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Naeem M, Zulfiqar M, Ballard DH, Billadello L, Cao G, Winter A, Lowdermilk M Tags: Clin Imaging Source Type: research

Community outreach and integration of breast radiologists.
We describe various methods of community outreach and integration attainable by breast imagers and how these can be used to develop relations with patients and providers, improve patient access, and inspire future breast imagers. Engagement in community outreach by the breast imager can positively impact breast radiologists, their radiology groups, and patients. PMID: 32492625 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 25, 2020 Category: Cancer & Oncology Authors: Phalak K, Gerlach K, Parikh JR Tags: Clin Imaging Source Type: research

The effect of proton pump inhibitors on survival outcomes in advanced hepatocellular carcinoma treated with sorafenib.
CONCLUSION: In a large high-quality dataset, PPI use was not observed to compromise the survival outcomes of advanced HCC patients initiated on sorafenib. PMID: 32449002 [PubMed - indexed for MEDLINE] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 18, 2020 Category: Cancer & Oncology Authors: Ruanglertboon W, Sorich MJ, Logan JM, Rowland A, Hopkins AM Tags: J Cancer Res Clin Oncol Source Type: research

Epidemiology of Brain Metastases.
Abstract Brain metastasis continues to be a devastating complication of systemic malignancy, affecting approximately 20% of all patients suffering from cancer. Despite being a major source of morbidity and mortality for this patient population, a nationwide, systematic mechanism for reporting of brain metastases does not exist. Better understanding the epidemiology of brain metastases will help identify individuals who are at greatest risk of developing them and guide clinicians in selecting patients who are most likely to benefit from brain metastasis surveillance and prophylaxis. PMID: 32921345 [PubMed - in...
Source: Clinical Genitourinary Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Sacks P, Rahman M Tags: Neurosurg Clin N Am Source Type: research

Pathological Features of Brain Metastases.
Abstract Metastases are the most common intracranial tumors in adults. Lung cancer, melanoma, renal cell carcinoma, and breast cancer are the most common primary tumors that metastasize to the brain. Improved detection of small metastases by MRI, and improved systemic therapy for primary tumors, resulted in increased incidence of brain metastasis. Advances in neuroanesthesia and neurosurgery have significantly improved the safety of surgical resection of brain metastases. Surgical approach and active management have become applicable for many patients. Subsequently, brain metastases diagnosis no longer equals pall...
Source: Clinical Genitourinary Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Tadros S, Ray-Chaudhury A Tags: Neurosurg Clin N Am Source Type: research