Efficacy and Safety of Rivaroxaban versus Warfarin in Patients with Nonvalvular Atrial Fibrillation and a History of Cancer: Observations from ROCKET AF.
Abstract Aims: The management of anticoagulation therapy in patients with atrial fibrillation (AF) and cancer is challenging due to increased thrombotic and bleeding risks. We sought to determine the safety and efficacy of rivaroxaban in patients with AF and a history of cancer. Methods and Results: ROCKET AF randomized 14,264 patients with AF to rivaroxaban or warfarin with a median follow-up of 1.9 years. Cox regression models were used to assess the association between cancer history and clinical outcomes, and the relative treatment effect of rivaroxaban versus warfarin in these patients. A total of 640 pa...
Source: Clinical Genitourinary Cancer - September 14, 2018 Category: Cancer & Oncology Authors: Chen ST, Hellkamp AS, Becker RC, Berkowitz SD, Breithardt G, Fox KAA, Hacke W, Halperin JL, Hankey GJ, Mahaffey KW, Nessel CC, Piccini JP, Singer DE, Patel MR, Melloni C Tags: Eur Heart J Qual Care Clin Outcomes Source Type: research

Magnetic Resonance Image-Guided Radiotherapy (MRIgRT): A 4.5-Year Clinical Experience.
DISCUSSION: MRIgRT is widely applicable within the field of radiation oncology and new clinical uses continue to emerge. At our institution to date, applications such as ART for gastrointestinal cancers and accelerated partial breast irradiation (APBI) for breast cancer have become dominant indications, although this is likely to continue to evolve. PMID: 30197095 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 6, 2018 Category: Cancer & Oncology Authors: Henke LE, Contreras JA, Green OL, Cai B, Kim H, Roach MC, Olsen JR, Fischer-Valuck B, Mullen DF, Kashani R, Thomas MA, Huang J, Zoberi I, Yang D, Rodriguez V, Bradley JD, Robinson CG, Parikh P, Mutic S, Michalski J Tags: Clin Oncol (R Coll Radiol) Source Type: research

Effect of multiple-dose osimertinib on the pharmacokinetics of simvastatin and rosuvastatin.
CONCLUSIONS: Osimertinib is unlikely to have any clinically relevant interaction with CYP3A substrates and has a weak inhibitory effect on BCRP. No new safety concerns were identified in either study. PMID: 30171779 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - September 1, 2018 Category: Cancer & Oncology Authors: Donald Harvey R, Aransay NR, Isambert N, Lee JS, Arkenau T, Vansteenkiste J, Dickinson PA, Bui K, Weilert D, So K, Thomas K, Vishwanathan K Tags: Br J Clin Pharmacol Source Type: research

Survival Study of Triple-Negative and Non-Triple-Negative Breast Cancer in a Brazilian Cohort.
ra MT Abstract Objective: To analyze the clinical, pathological, and sociodemographic aspects between triple-negative breast cancer (TNBC) and non-TNBC in a Brazilian cohort and identify potential prognostic factors. Methods: This hospital-based retrospective cohort study included 447 women with breast cancer treated at referral centers in Southeastern Brazil. Overall and disease-free survival were compared; prognostic factors were evaluated. Results: Triple-negative breast cancer corresponded to 19.5% of breast cancer diagnosis and was more prevalent among nonwhite and less educated women. The patients ...
Source: Clinical Genitourinary Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Gonçalves H, Guerra MR, Duarte Cintra JR, Fayer VA, Brum IV, Bustamante Teixeira MT Tags: Clin Med Insights Oncol Source Type: research

Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: results of the Ulm Birth Cohort Studies.
Abstract BACKGROUND: Soluble CD14 (sCD14) is one of many factors in human breast milk which may influence programming of the immune response in the breastfed child. Though previous studies have mostly found little association between sCD14 concentration in breast milk and atopic outcomes, recent evidence continues to support a role of sCD14 in immune-related disease. OBJECTIVE: We aimed to clarify whether an association exists between sCD14 concentration in human breast milk (m-sCD14) and child atopic dermatitis (AD) diagnosis by age 3 years within the context of two large birth cohorts. METHODS: Data we...
Source: Clinical Genitourinary Cancer - August 7, 2018 Category: Cancer & Oncology Authors: Logan CA, Weiss JM, Koenig W, Stahl B, Carr PR, Brenner H, Rothenbacher D, Genuneit J Tags: Clin Exp Allergy Source Type: research

Evaluation of a Novel Field-placement Algorithm for Locoregional Breast Cancer Radiotherapy Including the Internal Mammary Chain.
This study describes the development and evaluation of such an algorithm. MATERIALS AND METHODS: An algorithm was developed in which six points representing lymph node clinical target volume borders (based on European Society for Radiotherapy and Oncology consensus nodal contouring guidelines) were placed on computed tomography-defined anatomical landmarks and used to place tangential and nodal fields. Single-centre testing in 20 cases assessed the success of the algorithm in covering planning target volumes (PTVs) and adequately sparing organs at risk. Plans derived using the points algorithm were also compared with ...
Source: Clinical Genitourinary Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Ranger A, Dunlop A, Shah P, Amin K, Henderson D, Bartlett FR, Knowles C, Brigden B, Lacey C, Donovan E, Harris E, Kirby AM Tags: Clin Oncol (R Coll Radiol) Source Type: research

Diagnosis of brain metastases in breast cancer patients resulting from neurological symptoms.
CONCLUSIONS: Clinical symptoms and cancer characteristics were correlated with the development of CNSm. Specific risk and protective factors were identified. Among BC patients with neurological symptoms, CNSm should always be considered, especially in patients with certain oncological and clinical features. PMID: 30086430 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Cacho-Díaz B, Spínola-Maroño H, Arrieta VA, Granados-García M, Wegman-Ostrosky T, Mendoza-Olivas LG, Chávez-MacGregor M Tags: Clin Neurol Neurosurg Source Type: research

Effect of denosumab on bone mineral density in Japanese women with osteopenia treated with aromatase inhibitors for breast cancer: subgroup analyses of a Phase II study.
Conclusion: Twice-yearly treatment with denosumab was associated with increased BMD among Japanese women receiving adjuvant AI therapy, regardless of the baseline characteristics or skeletal site. PMID: 30022834 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 21, 2018 Category: Cancer & Oncology Authors: Nakatsukasa K, Koyama H, Ouchi Y, Sakaguchi K, Fujita Y, Matsuda T, Kato M, Konishi E, Taguchi T Tags: Ther Clin Risk Manag Source Type: research

Development of a Highly Sensitive Device for Counting the Number of Disease-Specific Exosomes in Human Sera.
CONCLUSIONS: The ExoCounter system exhibits high performance in the direct detection of exosomes in cell culture and human sera. This method may enable reliable analysis of liquid biopsies. PMID: 30021922 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Kabe Y, Suematsu M, Sakamoto S, Hirai M, Koike I, Hishiki T, Matsuda A, Hasegawa Y, Tsujita K, Ono M, Minegishi N, Hozawa A, Murakami Y, Kubo M, Itonaga M, Handa H Tags: Clin Chem Source Type: research

Differential altered expression of let-7a and miR-205 tumor-suppressor miRNAs in different subtypes of breast cancer under treatment with Taxol.
CONCLUSIONS: Our results confirmed a better response of HER2-overexpressing breast cancer to paclitaxel at the miRNA level. One putative reason could be the upregulation of tumor-suppressor miRNAs after treatment with paclitaxel. On the other hand, HER2-negative breast cancer cell lines showed a significantly decreased expression of tumor-suppressor miRNAs, a putative mechanism of resisting the therapy. PMID: 30019863 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Asghari F, Haghnavaz N, Shanehbandi D, Khaze V, Baradaran B, Kazemi T Tags: Adv Clin Exp Med Source Type: research

A randomized, open-label, Phase III trial of pertuzumab retreatment in HER2-positive locally advanced/metastatic breast cancer patients previously treated with pertuzumab, trastuzumab and chemotherapy: the Japan Breast Cancer Research Group-M05 PRECIOUS study.
Abstract The PRECIOUS study (UMIN000018202) is being conducted as a multicenter, randomized, open-label Phase III study to determine if retreatment with pertuzumab is more effective than conventional treatment in HER2-positive locally advanced (LA)/metastatic breast cancer (MBC) patients previously treated with pertuzumab, trastuzumab and chemotherapy. Patients are randomized 1:1 into chemotherapy plus trastuzumab with or without pertuzumab groups. The latest regimen before enrollment did not include pertuzumab, and the number of previous chemotherapy regimens for LA/MBC did not exceed three. The primary endpoint ...
Source: Clinical Genitourinary Cancer - July 18, 2018 Category: Cancer & Oncology Authors: Yamamoto Y, Iwata H, Ueno T, Taira N, Kashiwaba M, Takahashi M, Tada H, Tsugawa K, Toyama T, Niikura N, Hara F, Fujisawa T, Yoshinami T, Saji S, Takano T, Masuda N, Morita S, Toi M, Ohno S Tags: Jpn J Clin Oncol Source Type: research

Management of leptomeningeal metastasis in breast cancer.
Abstract Leptomeningeal metastasis (LM), which occurs when malignant cells spread to the central nervous system, is becoming an increasingly common complication in patients with breast cancer. Diagnosis and treatment of LM is challenging. Moreover, prognosis of patients with LM is poor, with a median survival of 6 months after diagnosis. This review highlights the strengths and limitations of currently available diagnostic tools and therapies for LM. The current treatments for LM, including radiotherapy, systemic therapy, and intrathecal treatment, aim to maintain the quality of life of patients by correcting neur...
Source: Clinical Genitourinary Cancer - July 7, 2018 Category: Cancer & Oncology Authors: Assi HI, Mahmoud T, Saadeh FS, El Darsa H Tags: Clin Neurol Neurosurg Source Type: research

Lower motor neuron syndrome in a patient with HER2-positive metastatic breast cancer: A case report and review of the literature.
We presented the first case of patient affected by HER2-positive breast tumor and possible paraneoplastic lower motor neuron disease. In literature, few cases are reported but no one highlights the tumor receptors' profile. Instead, HER2-positive breast cancers are prone to be related to anti-Yo-associated paraneoplastic cerebellar disorders. Anti-onconeural antibodies positivity can be rarely found, confirming that paraneoplastic MND have no specific biomarkers. The presence of CSF oligoclonal bands (OBs) suggests the presence of immune-mediated mechanism, in absence of other possible OBs causes. PMID: 30007590 [PubM...
Source: Clinical Genitourinary Cancer - July 6, 2018 Category: Cancer & Oncology Authors: Diamanti L, Quaquarini E, Berzero G, Bini P, Gastaldi M, Franciotta D, Alfonsi E, Ceroni M, Frascaroli M, Bernardo A, Marchioni E Tags: Clin Neurol Neurosurg Source Type: research

LncRNA HOXA-AS2 and its molecular mechanisms in human cancer.
Abstract Long non-coding RNAs (lncRNAs), are a novel class of noncoding RNAs, and are commonly defined as RNA molecules greater more than 200 nucleotides in length. Emerging research has indicated that lncRNA played a vital role in the pathophysiology of human tumorigenesis and progression by serving as tumor oncogenes or suppressors either oncogenes or tumor suppressor genes. LncRNA has been shown to get involved in participate various biological processes, such as cell growth, anti-apoptosis, migration and invasion. LncRNA HOXA cluster antisense RNA2 (HOXA-AS2) is a novel cancer-related lncRNA. that It was recen...
Source: Clinical Genitourinary Cancer - July 4, 2018 Category: Cancer & Oncology Authors: Wang J, Su Z, Lu S, Fu W, Liu Z, Jiang X, Tai S Tags: Clin Chim Acta Source Type: research

Thoracic paravertebral nerve block for treating contraction of the latissimus dorsi muscle after breast cancer surgery.
PMID: 29980006 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Ueshima H, Otake H Tags: J Clin Anesth Source Type: research

Identification of pathological complete response after neoadjuvant chemotherapy for breast cancer: comparison of greyscale ultrasound, shear wave elastography, and MRI.
CONCLUSIONS: SWE combined with greyscale US shows promise for end-of-treatment identification of response to NACT in women with breast cancer, with accuracies similar to breast MRI. This technique could be used to inform surgical decision-making after NACT. PMID: 29980324 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - July 3, 2018 Category: Cancer & Oncology Authors: Evans A, Whelehan P, Thompson A, Purdie C, Jordan L, Macaskill J, Henderson S, Vinnicombe S Tags: Clin Radiol Source Type: research

Ultrasound guided erector spinae plane block reduces postoperative opioid consumption following breast surgery: A randomized controlled study.
Kılıç CT Abstract STUDY OBJECTIVE: To evaluate the analgesic effect of ultrasound-guided erector spinae plane (ESP) block in breast cancer surgery. DESIGN: Randomized controlled, single-blinded trial. SETTING: Operating room. PATIENTS: Fifty ASA I-II patients aged 25-65 and scheduled for elective breast cancer surgery were included in the study. INTERVENTIONS: Patients were randomized into two groups, ESP and control. Single-shot ultrasound (US)-guided ESP block with 20 ml 0.25% bupivacaine at the T4 vertebral level was performed preoperatively to all patients in the ESP group. The c...
Source: Clinical Genitourinary Cancer - July 2, 2018 Category: Cancer & Oncology Authors: Gürkan Y, Aksu C, Kuş A, Yörükoğlu UH, Kılıç CT Tags: J Clin Anesth Source Type: research

Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline.
Abstract Purpose The Society for Integrative Oncology (SIO) produced an evidence-based guideline on use of integrative therapies during and after breast cancer treatment that was determined to be relevant to the American Society of Clinical Oncology (ASCO) membership. ASCO considered the guideline for endorsement. Methods The SIO guideline addressed the use of integrative therapies for the management of symptoms and adverse effects, such as anxiety and stress, mood disorders, fatigue, quality of life, chemotherapy-induced nausea and vomiting, lymphedema, chemotherapy-induced peripheral neuropathy, pain, and sleep ...
Source: Clinical Genitourinary Cancer - June 11, 2018 Category: Cancer & Oncology Authors: Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, Fouladbakhsh JM, Gil B, Hershman DL, Mansfield S, Mussallem DM, Mustian KM, Price E, Rafte S, Cohen L Tags: J Clin Oncol Source Type: research

Hormone Therapy: Key Points From NAMS 2017 Position Statement.
Abstract The goal of the 2017 North American Menopause Society Hormone Therapy (HT) Position Statement is to remove fear about HT and encourage individualized shared decision making, using best available evidence. Systemic HT is safe and effective for symptomatic menopausal women aged younger than 60 years and within 10 years of menopause. Special populations of early menopause, high risk for fracture, risk of breast or uterine cancer, and extended duration are discussed. With longer duration of use, periodic evaluation and reassessment of health risks are needed. Lowered doses, transdermal therapies or newer opti...
Source: Clinical Genitourinary Cancer - June 8, 2018 Category: Cancer & Oncology Authors: Pinkerton JV Tags: Clin Obstet Gynecol Source Type: research

Updates in the Evaluation and Management of Breast Cancer.
This article provides an overview of the management of noninvasive and invasive breast cancer, which is often complex and varies according to patient factors, disease stage, and breast cancer subtype. Although much progress has been made, continued research endeavors are ongoing; enrollment of eligible patients in prospective clinical trials is an essential way to improve patient outcomes. PMID: 29866283 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - June 1, 2018 Category: Cancer & Oncology Authors: O'Sullivan CC, Loprinzi CL, Haddad TC Tags: Mayo Clin Proc Source Type: research

AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor (EGFR).
Abstract Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE-λ was made for future studies in dogs as translational model patients. PMID: 29746883 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 7, 2018 Category: Cancer & Oncology Authors: Fazekas-Singer J, Singer J, Ilieva KM, Matz M, Herrmann I, Spillner E, Karagiannis SN, Jensen-Jarolim E Tags: J Allergy Clin Immunol Source Type: research

The 21-gene Recurrence Score ® assay predicts distant recurrence in lymph node-positive, hormone receptor-positive, breast cancer patients treated with adjuvant sequential epirubicin- and docetaxel-based or epirubicin-based chemotherapy (PACS-01 trial).
The 21-gene Recurrence Score® assay predicts distant recurrence in lymph node-positive, hormone receptor-positive, breast cancer patients treated with adjuvant sequential epirubicin- and docetaxel-based or epirubicin-based chemotherapy (PACS-01 trial). BMC Cancer. 2018 May 04;18(1):526 Authors: Penault-Llorca F, Filleron T, Asselain B, Baehner FL, Fumoleau P, Lacroix-Triki M, Anderson JM, Yoshizawa C, Cherbavaz DB, Shak S, Roca L, Sagan C, Lemonnier J, Martin AL, Roché H Abstract BACKGROUND: The 21-gene Recurrence Score (RS) result predicts outcome and chemotherapy benefit in node-negative ...
Source: Clinical Genitourinary Cancer - May 4, 2018 Category: Cancer & Oncology Authors: Penault-Llorca F, Filleron T, Asselain B, Baehner FL, Fumoleau P, Lacroix-Triki M, Anderson JM, Yoshizawa C, Cherbavaz DB, Shak S, Roca L, Sagan C, Lemonnier J, Martin AL, Roché H Tags: BMC Cancer Source Type: research

The unexpected impact of expressive writing on posttraumatic stress and growth in Chinese American breast cancer survivors.
CONCLUSIONS: These findings speak to the importance of examining whether interventions are equally efficacious in different cultures. PMID: 29727480 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 4, 2018 Category: Cancer & Oncology Authors: Gallagher MW, Long LJ, Tsai W, Stanton AL, Lu Q Tags: J Clin Psychol Source Type: research

Tumor cell expression of CD163 is associated to postoperative radiotherapy and poor prognosis in patients with breast cancer treated with breast-conserving surgery.
CONCLUSIONS: Our results suggest that macrophage phenotype in tumor cells results in radioresistance in breast cancer and shorter DFS after radiotherapy. PMID: 29725763 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Garvin S, Oda H, Arnesson LG, Lindström A, Shabo I Tags: J Cancer Res Clin Oncol Source Type: research

Cardiac autonomic modulation impairments in advanced breast cancer patients.
CONCLUSIONS: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging. PMID: 29721647 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Arab C, Vanderlei LCM, da Silva Paiva L, Fulghum KL, Fristachi CE, Nazario ACP, Elias S, Gebrim LH, Ferreira Filho C, Gidron Y, Ferreira C Tags: Clin Res Cardiol Source Type: research

Breast MR Imaging: Atlas of Anatomy, Physiology, Pathophysiology, and Breast Imaging Reporting and Data Systems Lexicon.
Abstract The latest edition of the Breast Imaging Reporting and Data Systems lexicon, copyrighted in 2013, contains several changes to the breast MR imaging section. Most changes were implemented to standardize descriptors across breast imaging modalities. New sections on special topics and implant evaluation are included. We review basic MR imaging breast anatomy and a detailed pictorial review of the Breast Imaging Reporting and Data Systems lexicon, including these new sections. In each section we discuss which descriptors are more concerning for malignancy and information radiologists can use to better categor...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Martaindale SR Tags: Magn Reson Imaging Clin N Am Source Type: research

Role of MR Imaging for the Locoregional Staging of Breast Cancer.
Abstract Breast MR imaging has been shown to identify unsuspected sites of cancer in the ipsilateral breast in 16% of women with newly diagnosed breast cancer. Breast MR imaging identifies occult cancer in the contralateral breast in 3% to 5% of women. Early evidence suggests that the added value of MR imaging for staging may be attenuated in women who also undergo tomosynthesis, particularly those with nondense breasts. Breast MR imaging is complementary to ultrasound imaging in evaluating regional nodal basins. Ongoing prospective randomized clinical trials should clarify the impact of preoperative breast MR ima...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Ray KM, Hayward JH, Joe BN Tags: Magn Reson Imaging Clin N Am Source Type: research

Role of MR Imaging in Neoadjuvant Therapy Monitoring.
Abstract Neoadjuvant chemotherapy (NAC) has become an important treatment approach for stage II/III breast cancers to downsize tumor and enable breast-conserving surgery for patients that may otherwise undergo mastectomy. MR imaging has the potential to identify early response or disease progression, enabling potential modification to NAC regimens. Detection of size and morphologic changes is better appreciated with MR imaging than other modalities and is different between molecular subtypes of breast cancer. The combination of DCE-MR imaging and DWI provides the highest sensitivity and specificity. Other new moda...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Le-Petross HT, Lim B Tags: Magn Reson Imaging Clin N Am Source Type: research

Problem-Solving MR Imaging for Equivocal Imaging Findings and Indeterminate Clinical Symptoms of the Breast.
Abstract Breast MR imaging is commonly used for high-risk screening and for assessing the extent of disease in patients with newly diagnosed breast cancer, but its utility for assessing suspicious symptoms and equivocal imaging findings is less widely accepted. The authors review current literature and guidelines regarding the use of breast MR imaging for these indications. Overall, problem-solving breast MR imaging is best reserved for pathologic nipple discharge and sonographically occult architectural distortion with limited biopsy options. Further study is necessary to define the role of problem-solving MR ima...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Cohen E, Leung JWT Tags: Magn Reson Imaging Clin N Am Source Type: research

MR Imaging-Guided Breast Interventions: Indications, Key Principles, and Imaging-Pathology Correlation.
Abstract MR imaging is now routinely performed for breast cancer screening and staging. For suspicious MR imaging-detected lesions that are mammographically and sonographically occult, MR imaging-guided breast interventions, including biopsy, clip placement, and preoperative needle localization, have been developed to permit accurate tissue diagnosis and aid in surgical planning. These procedures are safe, accurate, and effective when performed according to key principles, including proper patient selection, use of appropriate technique, adequate preprocedure preparation and postprocedure patient care, and postpro...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Santiago L, Candelaria RP, Huang ML Tags: Magn Reson Imaging Clin N Am Source Type: research

Developments in Breast Imaging: Update on New and Evolving MR Imaging and Molecular Imaging Techniques.
This article reviews new developments in breast imaging. There is growing interest in creating a shorter, less expensive MR protocol with broader applicability. There is an increasing focus on and consideration for the additive impact that functional analysis of breast pathology have on identifying and characterizing lesions. These developments apply to MR imaging and molecular imaging. This article reviews evolving breast imaging techniques with attention to strengths, weaknesses, and applications of these approaches. We aim to give the reader familiarity with the state of current developments in the field and to increase...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Heller SL, Heacock L, Moy L Tags: Magn Reson Imaging Clin N Am Source Type: research

Comparison of Contrast-Enhanced Mammography and Contrast-Enhanced Breast  MR Imaging.
Comparison of Contrast-Enhanced Mammography and Contrast-Enhanced Breast MR Imaging. Magn Reson Imaging Clin N Am. 2018 May;26(2):259-263 Authors: Lewin J Abstract Contrast-enhanced mammography (CEM) is a contrast-enhanced modality for breast cancer detection that utilizes iodinated contrast and dual-energy imaging performed on a digital mammography unit with only slight modifications. It is approved by the US Food and Drug Administration, commercially available, and in routine clinical use at centers around the world. It has similar sensitivity and specificity to MR Imaging and has advantages in...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Lewin J Tags: Magn Reson Imaging Clin N Am Source Type: research

Use of Breast-Specific PET Scanners and Comparison with MR Imaging.
Abstract The goals of this article are to discuss the role of breast-specific PET imaging of women with breast cancer, compare the clinical performance of positron emission mammography (PEM) and MR imaging for current indications, and provide recommendations for when women should undergo PEM instead of breast MR imaging. PMID: 29622131 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Narayanan D, Berg WA Tags: Magn Reson Imaging Clin N Am Source Type: research

Comparison of Breast MR Imaging with Molecular Breast Imaging in Breast Cancer Screening, Diagnosis, Staging, and Treatment Response Evaluation.
This article discusses clinical applications of breast MR imaging and MBI, and compares the performance of these techniques in breast cancer screening, diagnosis, staging, and treatment response evaluation. PMID: 29622132 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Rauch GM, Adrada BE Tags: Magn Reson Imaging Clin N Am Source Type: research

How Does MR Imaging Help Care for My Breast Cancer Patient? Perspective of a Surgical Oncologist.
Abstract MR imaging is now readily available for surgeons to incorporate into their practice, thus, begging the question, is this new modality clinically useful? Current literature and expert opinion are reviewed concerning the implementation of breast MR imaging to clinical management of breast cancer. Although breast MR imaging is acknowledged to be highly sensitive in detection of breast cancer, its routine application to surgical practice remains controversial because these gains in sensitivity have not been demonstrated to translate into improved long-term patient outcomes. Current clinical trials and the fut...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Raber B, Bea VJ, Bedrosian I Tags: Magn Reson Imaging Clin N Am Source Type: research

How Does MR Imaging Help Care for the Breast Cancer Patient? Perspective of a Medical Oncologist.
This article reviews the impact of MR imaging in different settings on medical oncology decision-making in patients with breast cancer. PMID: 29622134 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Raghavendra AS, Tripathy D Tags: Magn Reson Imaging Clin N Am Source Type: research

How Does MR Imaging Help Care for My Breast Cancer Patient? Perspective of a Radiation Oncologist.
Abstract Radiation therapy is used in many cases of both early and late breast cancer. The authors examine the role of MR imaging as it pertains to radiotherapy planning and treatment approaches for patients with breast cancer. MR imaging can assist the radiation oncologist in determining the best radiation approach and in creating treatment planning volumes. MR imaging may be useful in the setting of accelerated partial breast irradiation. Radiation oncologists should attend to MR breast images, when obtained, to ensure that these imaging findings are taken into consideration when developing a radiation therapy p...
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Christopherson KM, Smith BD Tags: Magn Reson Imaging Clin N Am Source Type: research

Breast MR Imaging in Era of Value-Based Medicine.
PMID: 29622138 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2018 Category: Cancer & Oncology Authors: Leung JWT Tags: Magn Reson Imaging Clin N Am Source Type: research

Pathology findings and clinical outcomes after risk reduction salpingo-oophorectomy in BRCA mutation carriers: a multicenter Spanish study.
CONCLUSION: The incidence of STIC after RRSO in BRCA mutation carriers is low (0.8%) and it presents an excellent oncological outcome. Patients after RRSO, however, run the risk to develop other types of cancer during follow-up and should be properly advised before the prophylactic surgery. PMID: 29623583 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 5, 2018 Category: Cancer & Oncology Authors: Minig L, Cabrera S, Oliver R, Couso A, Rubio MJ, Iacoponi S, Martin-Salamanca MB, Carballo-Rastrilla S, Cádenas-Rebollo JM, García-Garcia A, Gil-Ibáñez B, Juan-Fita MJ, Patrono MG Tags: Clin Transl Oncol Source Type: research

Lipid accumulation in human breast cancer cells injured by iron depletors.
CONCLUSIONS: Iron starvation induces a hypoxia-like program able to scavenge nutrients from the extracellular environment, and cells assume a hypertrophic phenotype. Such survival strategy is accompanied by the ER-dependent massive cytoplasmic vacuolization, mitochondrial dysfunctions, and LD accumulation and then evolves into cell death. LDs containing a greater proportion of unsaturated lipids are released as a consequence of cell death. The consequence of the disruption of iron metabolism in tumour tissue and the effects of LDs on intercellular communication, cancer-inflammation axis, and immunity remain to be explored....
Source: Clinical Genitourinary Cancer - April 3, 2018 Category: Cancer & Oncology Authors: De Bortoli M, Taverna E, Maffioli E, Casalini P, Crisafi F, Kumar V, Caccia C, Polli D, Tedeschi G, Bongarzone I Tags: J Exp Clin Cancer Res Source Type: research

Knowledge and practices on healthy eating among breast cancer patients on chemotherapy.
PMID: 29616947 [PubMed - in process] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 1, 2018 Category: Cancer & Oncology Authors: Bali G, Kyprianidou A, Dardavessis T, Theodoridis X, Matthaiou A, Anogeianaki A, Ainali A, Botsolis K, Vagionas A, Stoltidis D, Makrantonakis P, Andreadis C, Tirodimos I, Grammatikopoulou MG, Chourdakis M Tags: Clin Nutr ESPEN Source Type: research

Squamous cell carcinoma of the breast as a clinical diagnostic challenge.
Abstract Squamous cell carcinoma (SqCC) of the breast should be differentiated between the primary skin keratinizing squamous carcinoma and squamous metaplastic cancer. In the current study, the cases of two patients who were diagnosed with SqCC originated from skin and the breast were discussed. A fine-needle aspiration biopsy confirmed the presence of atypical squamous cells. In both cases, the microscopic examination of the surgical specimen revealed a malignant neoplasm differentiated into SqCC characterized by keratinizing cancer cells with abundant eosiphilic cytoplasm with large, hyperchromatic vesicular nu...
Source: Clinical Genitourinary Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Jakubowska K, Kańczuga-Koda L, Kisielewski W, Koda M, Famulski W Tags: Mol Clin Oncol Source Type: research

Significant improvement of bone mineral density by denosumab treatment in Japanese osteoporotic patients following breast cancer treatment.
Conclusion: Denosumab significantly increased L-BMD and H-BMD to comparable degrees in both groups; therefore, it represents a good therapeutic option for OP receiving breast cancer treatment as well as primary OP. Also, vitamin D supplementation is required due to the potential hypocalcemia, and estrogen may be responsible for the decrease of serum calcium in the breast cancer patients. PMID: 29559791 [PubMed] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2018 Category: Cancer & Oncology Authors: Nakamura Y, Kamimura M, Morikawa A, Taguchi A, Suzuki T, Kato H Tags: Ther Clin Risk Manag Source Type: research

Breast cancer: Changes in clonal dynamics predict response to palbociclib.
PMID: 29557393 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 20, 2018 Category: Cancer & Oncology Authors: Sidaway P Tags: Nat Rev Clin Oncol Source Type: research

Concurrent Veliparib With Chest Wall and Nodal Radiotherapy in Patients With Inflammatory or Locoregionally Recurrent Breast Cancer: The TBCRC 024 Phase I Multicenter Study.
Abstract Purpose Locoregional control for inflammatory breast cancers and chest wall recurrences is suboptimal, which has motivated interest in radiosensitization to intensify therapy. Preclinical studies have suggested a favorable therapeutic index when poly (ADP-ribose) polymerase inhibitors are used as radiosensitizers; clinical investigation is necessary to establish appropriate dosing and confirm safety. Patients and Methods We conducted a multi-institutional phase I study of veliparib and concurrent radiotherapy (RT) to the chest wall and regional lymph nodes in 30 patients with inflammatory or locally recur...
Source: Clinical Genitourinary Cancer - March 20, 2018 Category: Cancer & Oncology Authors: Jagsi R, Griffith KA, Bellon JR, Woodward WA, Horton JK, Ho A, Feng FY, Speers C, Overmoyer B, Sabel M, Schott AF, Pierce L, Translational Breast Cancer Research Consortium Tags: J Clin Oncol Source Type: research

Safety and Antitumor Activity of Pembrolizumab in Patients with Estrogen Receptor ‒Positive/Human Epidermal Growth Factor Receptor 2‒Negative Advanced Breast Cancer.
CONCLUSIONS: Pembrolizumab was well-tolerated with modest but durable objective response in certain patients with previously treated, advanced, PD-L1‒positive, ER+/HER2- breast cancer. PMID: 29559561 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 20, 2018 Category: Cancer & Oncology Authors: Rugo HS, Delord JP, Im SA, Ott PA, Piha-Paul SA, Bedard PL, Sachev J, Le Tourneau C, van Brummelen EMJ, Varga A, Salgado R, Loi S, Saraf S, Pietrangelo D, Karantza V, Tan AR Tags: Clin Cancer Res Source Type: research

Targeting bromodomain and extra-terminal (BET) family proteins in castration resistant prostate cancer (CRPC).
, Swain A, de Bono JS Abstract PURPOSE:  Persistent androgen receptor (AR) signaling drives castration resistant prostate cancer (CRPC) and confers resistance to AR targeting therapies. Novel therapeutic strategies to overcome this are urgently required. We evaluated how bromodomain and extra-terminal (BET) protein inhibitors (BETi) abrogate aberrant AR signaling in CRPC. EXPERIMENTAL DESIGN:  We determined associations between BET expression, AR driven transcription and patient outcome; and the effect and mechanism by which chemical BETi (JQ1 and GSK1210151A; I-BET151) and BET family protein knockd...
Source: Clinical Genitourinary Cancer - March 19, 2018 Category: Cancer & Oncology Authors: Welti J, Sharp A, Yuan W, Dolling DI, Nava Rodrigues D, Figueiredo I, Gil V, Neeb A, Clarke M, Seed G, Crespo M, Sumanasuriya S, Ning J, Knight E, Francis JC, Hughes A, Halsey WS, Paschalis A, Mani RS, Raj GV, Plymate S, Carreira S, Boysen G, Chinnaiyan A Tags: Clin Cancer Res Source Type: research

Triple-negative breast cancers - a panoply of cancer types.
PMID: 29555966 [PubMed - as supplied by publisher] (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 19, 2018 Category: Cancer & Oncology Authors: Pareja F, Reis-Filho JS Tags: Nat Rev Clin Oncol Source Type: research

Clinicopathological features of metaplastic breast carcinoma.
CONCLUSIONS: Metaplastic carcinoma of the breast is relatively rare and, in our series, its incidence was 0.6%. According to its immunohistochemical characteristics, MpBC can be interpreted as a subgroup of triplenegative breast cancers (TNBC). Five of the presented patients resembled the subgroup of TNBC with a basaloid phenotype. The chemotherapy regimens suggested in the treatment of MpBC are platin in the epithelial subgroup and high-dose anthracycline in the mesenchymal subgroup. There is a need of new studies that evaluate different choices of treatment as MpBC has a bad prognosis and an aggressive nature. PMID:...
Source: Clinical Genitourinary Cancer - March 19, 2018 Category: Cancer & Oncology Authors: Hasdemir OA, Tokgöz S, Köybaşıoğlu F, Karabacak H, Yücesoy C, İmamoğlu Gİ Tags: Adv Clin Exp Med Source Type: research

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Conclusions: We recommend making a diagnosis of hypogonadism only in men with symptoms and signs consistent with testosterone (T) deficiency and unequivocally and consistently low serum T concentrations. We recommend measuring fasting morning total T concentrations using an accurate and reliable assay as the initial diagnostic test. We recommend confirming the diagnosis by repeating the measurement of morning fasting total T concentrations. In men whose total T is near the lower limit of normal or who have a condition that alters sex hormone-binding globulin, we recommend obtaining a free T concentration using either equil...
Source: Clinical Genitourinary Cancer - March 17, 2018 Category: Cancer & Oncology Authors: Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA Tags: J Clin Endocrinol Metab Source Type: research