Clinical factors associated with patterns of endocrine therapy adherence in premenopausal breast cancer patients
CONCLUSIONS: Women with stage I cancer, no chemotherapy, higher comorbidity burden, and history of chronic non-cancer medication use were less likely to adhere to AET. Taking steps to promote adherence in these groups of women may reduce their risk of recurrence.PMID:38589932 | DOI:10.1186/s13058-024-01819-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 8, 2024 Category: Cancer & Oncology Authors: Kirsten M Woolpert Julie A Schmidt Thomas P Ahern Cathrine F Hjorth D óra K Farkas Bent Ejlertsen Lindsay J Collin Timothy L Lash Deirdre P Cronin-Fenton Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis
In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells. Using an ex vivo pulmonary metastasis assay (PuMA), we observed that the lung microenvironment supports colonization and growth of ALDHhiCD44+ TNBC cells, potentially via interactions with lung-derived FGF2. Exposure of TNBC cells to lung-conditioned media (LCM) generated from mice bearing TNBC primary tumors (tbLCM) significantly enhanced the proportion of ALDHhiCD44+ cells compared to control or LCM from tumor-naïve mice (tnLCM). Further analysis usin...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Vasudeva Bhat Matthew Piaseczny David Goodale Urvi Patel Ashkan Sadri Alison L Allan Source Type: research
Is Immediate Breast Reconstruction With a Latissimus Dorsi Myocutaneous Flap Safe for Starting Adjuvant Chemotherapy in Patients With Breast Cancer?
CONCLUSION: Major postoperative complications significantly delayed initiation of adjuvant chemotherapy in oncological patients who underwent radical breast surgery followed by immediate reconstruction with a latissimus dorsi myocutaneous flap and silicone implants.PMID:38582616 | DOI:10.1016/j.clbc.2024.03.003 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Gabriel Salum D'Alessandro Alexandre Mendon ça Munhoz Fabiana Midori Takeuchi Alejandro Povedano Jo ão Carlos Sampaio Goes Source Type: research
The Role of Immunotherapy in Triple-Negative Breast Cancer (TNBC)
Clin Breast Cancer. 2024 Mar 6:S1526-8209(24)00061-2. doi: 10.1016/j.clbc.2024.03.001. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype, generally associated with a high risk of recurrence and poor prognosis. Our understanding of the heterogeneity of TNBC has increased over the past decade, and with it a recognition that some TNBCs are immunogenically active. This finding has led to the investigation of immunotherapy-based approaches for treatment of both early and advanced-stage TNBC. In this review, we provide an overview of the biologic rationale for immunotherapy...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Elena Michaels Nan Chen Rita Nanda Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis
In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells. Using an ex vivo pulmonary metastasis assay (PuMA), we observed that the lung microenvironment supports colonization and growth of ALDHhiCD44+ TNBC cells, potentially via interactions with lung-derived FGF2. Exposure of TNBC cells to lung-conditioned media (LCM) generated from mice bearing TNBC primary tumors (tbLCM) significantly enhanced the proportion of ALDHhiCD44+ cells compared to control or LCM from tumor-naïve mice (tnLCM). Further analysis usin...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Vasudeva Bhat Matthew Piaseczny David Goodale Urvi Patel Ashkan Sadri Alison L Allan Source Type: research
Is Immediate Breast Reconstruction With a Latissimus Dorsi Myocutaneous Flap Safe for Starting Adjuvant Chemotherapy in Patients With Breast Cancer?
CONCLUSION: Major postoperative complications significantly delayed initiation of adjuvant chemotherapy in oncological patients who underwent radical breast surgery followed by immediate reconstruction with a latissimus dorsi myocutaneous flap and silicone implants.PMID:38582616 | DOI:10.1016/j.clbc.2024.03.003 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Gabriel Salum D'Alessandro Alexandre Mendon ça Munhoz Fabiana Midori Takeuchi Alejandro Povedano Jo ão Carlos Sampaio Goes Source Type: research
The Role of Immunotherapy in Triple-Negative Breast Cancer (TNBC)
Clin Breast Cancer. 2024 Mar 6:S1526-8209(24)00061-2. doi: 10.1016/j.clbc.2024.03.001. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) is an aggressive breast cancer subtype, generally associated with a high risk of recurrence and poor prognosis. Our understanding of the heterogeneity of TNBC has increased over the past decade, and with it a recognition that some TNBCs are immunogenically active. This finding has led to the investigation of immunotherapy-based approaches for treatment of both early and advanced-stage TNBC. In this review, we provide an overview of the biologic rationale for immunotherapy...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Elena Michaels Nan Chen Rita Nanda Source Type: research
Genomic ancestry and cancer among Latin Americans
Clin Transl Oncol. 2024 Apr 6. doi: 10.1007/s12094-024-03415-6. Online ahead of print.ABSTRACTLatin American populations, characterized by intricate admixture patterns resulting from the intermingling of ancestries from European, Native American (NA) Asian, and African ancestries which result in a vast and complex genetic landscape, harboring unique combinations of novel variants. This genetic diversity not only poses challenges in traditional population genetics methods but also opens avenues for a deeper understanding of its implications in health. In cancer, the interplay between genetic ancestry, lifestyle factors, and...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Alejandro Ru íz-Patiño Leonardo Rojas Jairo Zuluaga Oscar Arrieta Luis Corrales Claudio Mart ín Sandra Franco Luis Raez Christian Rolfo Natalia S ánchez Andr és Felipe Cardona Source Type: research
Lung-derived soluble factors support stemness/plasticity and metastatic behaviour of breast cancer cells via the FGF2-DACH1 axis
In this study, we hypothesized that soluble lung-derived factors secreted in the presence of a primary TNBC tumor can influence stemness/plasticity of breast cancer cells. Using an ex vivo pulmonary metastasis assay (PuMA), we observed that the lung microenvironment supports colonization and growth of ALDHhiCD44+ TNBC cells, potentially via interactions with lung-derived FGF2. Exposure of TNBC cells to lung-conditioned media (LCM) generated from mice bearing TNBC primary tumors (tbLCM) significantly enhanced the proportion of ALDHhiCD44+ cells compared to control or LCM from tumor-naïve mice (tnLCM). Further analysis usin...
Source: Clinical Genitourinary Cancer - April 6, 2024 Category: Cancer & Oncology Authors: Vasudeva Bhat Matthew Piaseczny David Goodale Urvi Patel Ashkan Sadri Alison L Allan Source Type: research
Ferroptosis biomarkers predict tumor mutation burden's impact on prognosis in HER2-positive breast cancer
CONCLUSION: Our model helps guide the prognosis of HER2+ breast cancer patients, and its combination with the TMB can aid in more accurate assessment of patient prognosis and provide new ideas for further diagnosis and treatment.PMID:38576597 | PMC:PMC10989258 | DOI:10.5306/wjco.v15.i3.391 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Jin-Yu Shi Xin Che Rui Wen Si-Jia Hou Yu-Jia Xi Yi-Qian Feng Ling-Xiao Wang Shi-Jia Liu Wen-Hao Lv Ya-Fen Zhang Source Type: research
Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-kappabeta/TNF-alpha Axis in Breast Cancer
This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic bio...
Source: Clinical Genitourinary Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Sahar A Abdel-Samed Walaa G Hozyen Saeed M Shaaban Nabil A Hasona Source Type: research
Circulating miRNA-21 Levels in Breast Cancer Patients Before and After Chemotherapy and Its Association with Clinical Improvement
Indian J Clin Biochem. 2024 Apr;39(2):214-220. doi: 10.1007/s12291-023-01129-0. Epub 2023 Mar 30.ABSTRACTBreast cancer is the most frequent type of cancer in women, many patients experience recurrences and metastasis. miR-21 (microRNA-21) as biomarker is under investigation for breast cancer. At present, there is very limited information available regarding effect of chemotherapy on miR-21 expression in breast cancer and its correlation with the clinical improvement. Hence, this study was planned to evaluate the effect of chemotherapy on miR-21 in metastatic breast cancer and its relationship with the clinical outcome. Fem...
Source: Clinical Genitourinary Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Sanchi Sukhija Purvi Purohit Puneet Pareek Pawan Kumar Garg Jeewan Ram Vishnoi Poonam Abhay Elhence Shobhan Babu Varthya Praveen Sharma Sneha Ambwani Jaykaran Charan Source Type: research
Prognostic impact of tumor-associated neutrophils in breast cancer
CONCLUSION: The present results suggest that a higher density of TANs correlates with unfavorable prognostic factors in breast cancer. Further research on clinicopathological and genetic factors associated with TANs in breast cancer is needed.PMID:38577697 | PMC:PMC10988089 | DOI:10.62347/JQDQ1527 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - April 5, 2024 Category: Cancer & Oncology Authors: Akinari Kakumoto Tsengelmaa Jamiyan Hajime Kuroda Oi Harada Tomomi Yamaguchi-Isochi Shogo Baba Yasutaka Kato Hiroshi Nishihara Hiroyuki Kawami Source Type: research
