Optimal timing of prophylactic pegylated G-CSF after chemotherapy administration for patients with cancer: a systematic review and meta-analysis from Clinical Practice Guidelines for the use of G-CSF 2022
CONCLUSIONS: Both Day 2 and Days 3-5 were weakly recommended for pegylated G-CSF administration post-chemotherapy in patients with cancer. The limited evidence highlights the need for further research to refine recommendations.PMID:38526621 | DOI:10.1007/s10147-024-02499-y (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Yukinori Ozaki Takamichi Yokoe Tetsuhiro Yoshinami Kazuki Nozawa Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Yuji Miura Makoto Endo Shingo Yano Dai Maruyama Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito Eishi Baba Nobuaki Ochi Toshio K Source Type: research
Osteopontin promotes tumor growth and metastasis and GPX4-mediated anti-lipid peroxidation in triple-negative breast cancer by activating the PI3k/Akt/mTOR pathway
CONCLUSION: OPN promoted tumor sphere formation and angiogenesis in TNBC by activating the PI3K/AKT/mTOR pathway to regulate GPX4-mediated anti-lipid peroxidation levels.PMID:38526702 | DOI:10.1007/s00432-024-05658-w (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 25, 2024 Category: Cancer & Oncology Authors: Man Guo Mengyue Liu Weihan Li Cao Wang Lu Zhang Hao Zhang Source Type: research
Emerging measurements for tumor-infiltrating lymphocytes in breast cancer
Jpn J Clin Oncol. 2024 Mar 23:hyae033. doi: 10.1093/jjco/hyae033. Online ahead of print.ABSTRACTTumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers in breast cancer. Recently, immune checkpoint inhibitors, which directly target tumor-infiltrating lymphocytes, have become part of standard of care treatment for triple-negative breast cancer. Surprisingly, tumor-infiltrating lymphocytes quantified by conventional methods do not predict respon...
Source: Clinical Genitourinary Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Rongrong Wu Yoshiya Horimoto Masanori Oshi Matthew G K Benesch Thaer Khoury Kazuaki Takabe Takashi Ishikawa Source Type: research
Skin marker combined with surface-guided auto-positioning for breast DIBH radiotherapy daily initial patient setup: An optimal schedule for both accuracy and efficiency
CONCLUSION: SGRT one-key calibration was found to be more suitable when followed by skin marker/tattoo and in-room laser positioning, establishing it as an optimal daily initial set-up protocol for breast DIBH radiotherapy. This modality also proved to be suitable for free-breathing breast cancer radiotherapy, and its widespread clinical use is recommended.PMID:38522035 | DOI:10.1002/acm2.14319 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Jianjun Lai Zhizeng Luo Lu Jiang Haili Hu Chang Gao Chuanfeng Zhang Liting Chen Jing Wu Zhibing Wu Source Type: research
Through Clinicians Eyes: Use of an In-consultation Patient Decision Aid in Radiation Treatment for Early Breast Cancer. A Qualitative Study
CONCLUSION: Using an in-consultation Decision Helper has the potential for individualized, structured patient engagement in decision making. There is a need for patient decision aids in clinical guidelines to ensure patient engagement in decision making.PMID:38523041 | DOI:10.1016/j.clbc.2024.02.009 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Stine Rauff S øndergaard Mette Stie Troels Bechmann Birgitte Vrou Offersen Mette Holck Nielsen Mette M øller Leonard L Berry Robert Zachariae Karina Dahl Steffensen Lea Lund Source Type: research
Emerging measurements for tumor-infiltrating lymphocytes in breast cancer
Jpn J Clin Oncol. 2024 Mar 23:hyae033. doi: 10.1093/jjco/hyae033. Online ahead of print.ABSTRACTTumor-infiltrating lymphocytes are a general term for lymphocytes or immune cells infiltrating the tumor microenvironment. Numerous studies have demonstrated tumor-infiltrating lymphocytes to be robust prognostic and predictive biomarkers in breast cancer. Recently, immune checkpoint inhibitors, which directly target tumor-infiltrating lymphocytes, have become part of standard of care treatment for triple-negative breast cancer. Surprisingly, tumor-infiltrating lymphocytes quantified by conventional methods do not predict respon...
Source: Clinical Genitourinary Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Rongrong Wu Yoshiya Horimoto Masanori Oshi Matthew G K Benesch Thaer Khoury Kazuaki Takabe Takashi Ishikawa Source Type: research
Skin marker combined with surface-guided auto-positioning for breast DIBH radiotherapy daily initial patient setup: An optimal schedule for both accuracy and efficiency
CONCLUSION: SGRT one-key calibration was found to be more suitable when followed by skin marker/tattoo and in-room laser positioning, establishing it as an optimal daily initial set-up protocol for breast DIBH radiotherapy. This modality also proved to be suitable for free-breathing breast cancer radiotherapy, and its widespread clinical use is recommended.PMID:38522035 | DOI:10.1002/acm2.14319 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 24, 2024 Category: Cancer & Oncology Authors: Jianjun Lai Zhizeng Luo Lu Jiang Haili Hu Chang Gao Chuanfeng Zhang Liting Chen Jing Wu Zhibing Wu Source Type: research
Elderly patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with CDK4/6 inhibitors in a multicentre cohort
CONCLUSIONS: Our RWD suggests that elderly patients, when compared to those under 70, experience similar survival outcomes and exhibit comparable tolerance for CDK4/6i therapy.PMID:38519708 | DOI:10.1007/s12094-024-03399-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 23, 2024 Category: Cancer & Oncology Authors: Helena Pla Eudald Felip Ver ónica Obadia Sonia Pernas Gemma Vi ñas Mireia Margel í Roser Fort-Culillas Sonia Del Barco Nuria Sabat é Eduard Fort Clara Lezcano Beatriz Cirauqui Vanesa Quiroga Agostina Stradella Miguel Gil Gil Anna Esteve Sabela Recalde Source Type: research
Construction and Validation of a Nomogram Predicting the Overall Survival Benefit of Unilateral Breast Cancer Patients Undergoing Contralateral Prophylactic Mastectomy
CONCLUSION: This study developed and validated a practical nomogram to predict the OS of UBC patients undergoing CPM, which provided a beneficial tool for clinical decision-making management.PMID:38521702 | DOI:10.1016/j.clbc.2024.02.001 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 23, 2024 Category: Cancer & Oncology Authors: Luyao Dai Wenyu Yan Xueting Ren Dandan Liu Lidan Chang Shuai Lin Hao Wu Huafeng Kang Xiaobin Ma Source Type: research
PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers
CONCLUSION: Our results open the way for further studies using PROM2 as a bio-target in resort situations in human metastatic melanoma and also in other cancer types.PMID:38515278 | PMC:PMC10958126 | DOI:10.1002/ctm2.1632 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Justine Paris Claire Wilhelm Celeste Lebb é Mohammed Elmallah Fr édéric Pamoukdjian Audrey H éraud Guillaume Gapihan Aurore Van De Walle Van Nhan Tran Diaddin Hamdan Clara Allayous Maxime Battistella Emmanuel Van Glabeke Kah Wai Lim Christophe Leboeuf Source Type: research
Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results
CONCLUSIONS: One-week UHF adjuvant locoregional radiation is well-tolerated, displaying low-toxicity profiles comparable to other studies using similar irradiation schedules.PMID:38516338 | PMC:PMC10955656 | DOI:10.1016/j.ctro.2024.100764 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Ivica Ratosa Angel Montero Raquel Ciervide Beatriz Alvarez Mariola Garc ía-Aranda Jeannette Valero Xin Chen-Zhao Mercedes Lopez Daniel Zucca Ovidio Hernando Emilio S ánchez Miguel Angel de la Casa Rosa Alonso Pedro Fernandez-Leton Carmen Rubio Source Type: research
Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
How Long Does Contouring Really Take? Results of the Royal College of Radiologists Contouring Surveys
CONCLUSION: Contouring for radical radiotherapy is complex and time-consuming, and despite increasing involvement of non-medical professionals, clinical oncology consultants remain the primary practitioners. Peer review practice is variable and time is often a limiting factor. Many factors influence the time required for contouring, and departments should take these factors and the need for peer-review into account when developing job plans.PMID:38519383 | DOI:10.1016/j.clon.2024.03.005 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: E Montague T Roques K Spencer A Burnett J Lourenco N Thorp Source Type: research
PROM2 overexpression induces metastatic potential through epithelial-to-mesenchymal transition and ferroptosis resistance in human cancers
CONCLUSION: Our results open the way for further studies using PROM2 as a bio-target in resort situations in human metastatic melanoma and also in other cancer types.PMID:38515278 | DOI:10.1002/ctm2.1632 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Justine Paris Claire Wilhelm Celeste Lebb é Mohammed Elmallah Fr édéric Pamoukdjian Audrey H éraud Guillaume Gapihan Aurore Van De Walle Van Nhan Tran Diaddin Hamdan Clara Allayous Maxime Battistella Emmanuel Van Glabeke Kah Wai Lim Christophe Leboeuf Source Type: research
Ultra-hypofractionated one-week locoregional radiotherapy for patients with early breast cancer: Acute toxicity results
CONCLUSIONS: One-week UHF adjuvant locoregional radiation is well-tolerated, displaying low-toxicity profiles comparable to other studies using similar irradiation schedules.PMID:38516338 | PMC:PMC10955656 | DOI:10.1016/j.ctro.2024.100764 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Ivica Ratosa Angel Montero Raquel Ciervide Beatriz Alvarez Mariola Garc ía-Aranda Jeannette Valero Xin Chen-Zhao Mercedes Lopez Daniel Zucca Ovidio Hernando Emilio S ánchez Miguel Angel de la Casa Rosa Alonso Pedro Fernandez-Leton Carmen Rubio Source Type: research
