Effectiveness and safety of primary prophylaxis of granulocyte colony-stimulating factor during dose-dense chemotherapy for urothelial cancer: Clinical Practice Guidelines for the Use of G-CSF 2022
Int J Clin Oncol. 2024 Mar 22. doi: 10.1007/s10147-024-02491-6. Online ahead of print.ABSTRACTGranulocyte colony-stimulating factor (G-CSF) decreases the incidence, duration, and severity of febrile neutropenia (FN); however, dose reduction or withdrawal is often preferred in the management of adverse events in the treatment of urothelial cancer. It is also important to maintain therapeutic intensity in order to control disease progression and thereby relieve symptoms, such as hematuria, infection, bleeding, and pain, as well as to prolong the survival. In this clinical question, we compared treatment with primary prophyla...
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: Keita Uchino Shingo Tamura Shoji Kimura Keisuke Shigeta Takahiro Kimura Yukinori Ozaki Hiroshi Nishio Kenji Tsuchihashi Eiki Ichihara Makoto Endo Shingo Yano Dai Maruyama Tetsuhiro Yoshinami Nobuyuki Susumu Munetaka Takekuma Takashi Motohashi Mamoru Ito E Source Type: research
How Long Does Contouring Really Take? Results of the Royal College of Radiologists Contouring Surveys
CONCLUSION: Contouring for radical radiotherapy is complex and time-consuming, and despite increasing involvement of non-medical professionals, clinical oncology consultants remain the primary practitioners. Peer review practice is variable and time is often a limiting factor. Many factors influence the time required for contouring, and departments should take these factors and the need for peer-review into account when developing job plans.PMID:38519383 | DOI:10.1016/j.clon.2024.03.005 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 22, 2024 Category: Cancer & Oncology Authors: E Montague T Roques K Spencer A Burnett J Lourenco N Thorp Source Type: research
Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings
CONCLUSIONS: Weekly carboplatin exhibited comparable toxicity, a trend toward fewer interruptions, and similar pCR rates. Prospective studies are essential for validating these findings.PMID:38509430 | DOI:10.1007/s12094-024-03430-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Ana Isabel Martin-Quesada Elisenda Llabres-Valent í Cristina Mar ía Montesdeoca-Godoy Carla Mart ín-Abreu Cristina Alem án-Sánchez Natalia Rodr íguez-Pérez Alicia Herrero-M árquez Josefina Cruz-Jurado Mar ía Hernández-Sosa Melody Marrero-Garc í Source Type: research
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Clin Proteomics. 2024 Mar 20;21(1):24. doi: 10.1186/s12014-024-09476-7.ABSTRACTMetastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year survival rate of only 11%, necessitating identification of novel treatment paradigms. Tumor tissue specimens from patients with PDAC, breast cancer, and other solid tumor malignancies were collected and tumor cells were enriched using laser microdissection (LMD). Reverse phase protein array (RPPA) analysis was performed on enriched tumor cell lysates to quantify a 32-protein/phosphoprotein biomarker panel comprising ...
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Jamie Randall Allison L Hunt Aratara Nutcharoen Laura Johnston Safae Chouraichi Hongkun Wang Arthur Winer Raymond Wadlow Jasmine Huynh Justin Davis Brian Corgiat Nicholas W Bateman John F Deeken Emanuel F Petricoin Thomas P Conrads Timothy L Cannon Source Type: research
The Effect of a Required 48-Hour Window to Schedule Genetic Counseling on Time From Diagnosis of Breast Cancer to Surgery
This article examines the effect of time from diagnosis of breast cancer to surgery by requiring nurse navigators to contact the genetic counseling office within 48 hours of the diagnosis to schedule an appointment for the patient as soon as possible.METHODS: Using a quasiexperimental design, data of time from diagnosis to surgery among patients with breast cancer were collected retrospectively preintervention (N = 30) and prospectively postintervention (N = 30).FINDINGS: Time from diagnosis to surgery decreased significantly from pre- (mean = 50.3 days, SD = 22 days) to postintervention (mean = 39 days, SD = 16 days) (t =...
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Kiera Hobbs Peggy Wheeler Sara Campbell Charlie Workman Martha Monroe Claire Davies Source Type: research
Prevention, Surveillance, and Treatment of Breast Cancer-Related Lymphedema: The Role of the Advanced Practice Provider
Clin J Oncol Nurs. 2024 Mar 15;28(2):122-127. doi: 10.1188/24.CJON.122-127.ABSTRACTBreast cancer-related lymphedema is a lifelong disease associated with decreased quality of life and increased healthcare costs. Evidence supports early detection and prompt treatment through prospective surveillance models.PMID:38511916 | DOI:10.1188/24.CJON.122-127 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Leslie A McGrath Emily Bloomfield Source Type: research
A Signal-finding Study of Abemaciclib in Heavily Pretreated Patients with Metastatic Castration-Resistant Prostate Cancer: Results from CYCLONE 1
CONCLUSION: Abemaciclib monotherapy was well tolerated and showed clinical activity in this heavily pretreated population, nearly half with visceral metastases. This study is considered preliminary proof-of-concept and designates CDK4/6 as a valid therapeutic target in prostate cancer.PMID:38512117 | DOI:10.1158/1078-0432.CCR-23-3436 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Neeraj Agarwal Daniel Castellano Teresa Alonso-Gordoa Jose Angel Arranz Arija Emeline Colomba Gwenaelle Gravis Loic Mourey Stephane Oudard Aude Fl échon Macarena Gonzalez Pablo M Maroto Michael T Schweizer Enrique Gallardo Erica Johnston Arjun Balar Nadi Source Type: research
Predicting pathological complete response to neoadjuvant chemotherapy in breast cancer patients: use of MRI radiomics data from three regions with multiple machine learning algorithms
CONCLUSION: The addition of the BPE MRI signature improved the prediction of pCR in BCa patients who received NACT. These results suggest that the features of the peritumoral microenvironment are related to the efficacy of NACT.PMID:38512406 | DOI:10.1007/s00432-024-05680-y (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Guangying Zheng Jiaxuan Peng Zhenyu Shu Hui Jin Lu Han Zhongyu Yuan Xue Qin Jie Hou Xiaodong He Xiangyang Gong Source Type: research
Identification and validation of neutrophils-related subtypes and prognosis model in triple negative breast cancer
CONCLUSION: Based on the degree of gene expression linked to neutrophils, a unique prognostic model was created. MYO1D could be a potential prognostic biomarker in TNBC patients and also a prospective target for therapy.PMID:38512527 | DOI:10.1007/s00432-024-05651-3 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Shanqi Li Yuzhou Qian Wanchen Xie Xinyu Li Jiaying Wei Long Wang Guosheng Ren Xuedong Yin Source Type: research
Cancer Treatment Disparities in People With HIV in the United States, 2001-2019
CONCLUSION: Disparities in receipt of cancer treatment persist for PWH in the United States in contemporary time periods. Solutions to address inequitable receipt of cancer treatment among PWH are urgently needed.PMID:38513161 | DOI:10.1200/JCO.23.02366 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Jennifer K McGee-Avila Gita Suneja Eric A Engels Anne F Rositch Marie-Josephe Horner Qianlai Luo Meredith S Shiels Jessica Y Islam Source Type: research
PACE: A Randomized Phase II Study of Fulvestrant, Palbociclib, and Avelumab After Progression on Cyclin-Dependent Kinase 4/6 Inhibitor and Aromatase Inhibitor for Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor-Negative Metastatic Breast Cancer
CONCLUSION: The addition of palbociclib to fulvestrant did not improve PFS versus fulvestrant alone among patients with hormone receptor-positive/HER2- MBC whose disease had progressed on a previous CDK4/6i plus AI. The increased PFS seen with the addition of avelumab warrants further investigation in this patient population.PMID:38513188 | DOI:10.1200/JCO.23.01940 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Erica L Mayer Yue Ren Nikhil Wagle Reshma Mahtani Cynthia Ma Angela DeMichele Massimo Cristofanilli Jane Meisel Kathy D Miller Yara Abdou Elizabeth C Riley Rubina Qamar Priyanka Sharma Sonya Reid Natalie Sinclair Meredith Faggen Caroline C Block Naomi Ko Source Type: research
Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis
CONCLUSION: The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.PMID:38514057 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Chunfang Xi Zhendi Song Qingyu Cui Ye Zhao Kaifu Li Hua Kang Source Type: research
The Impact of Initial Tumor Response on Survival Outcomes of Patients With HER2-Positive Advanced Breast Cancer Treated With Docetaxel, Trastuzumab, and Pertuzumab: An Exploratory Analysis of the CLEOPATRA Trial
CONCLUSIONS: Our findings suggest that radiological CR at first disease re-evaluation is associated with more prolonged survival; this might result from stronger dependence on HER2 pathway addiction, supporting the need for further translational research.PMID:38514306 | DOI:10.1016/j.clbc.2024.02.012 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Veronique Debien Elisa Agostinetto Marco Bruzzone Marcello Ceppi Diogo Martins-Branco Chiara Molinelli Flavia Jacobs Guilherme Nader-Marta Matteo Lambertini Evandro de Azambuja Source Type: research
Comparative study of weekly and three-weekly neoadjuvant carboplatin in triple-negative breast cancer: retrospective analysis in real-world settings
CONCLUSIONS: Weekly carboplatin exhibited comparable toxicity, a trend toward fewer interruptions, and similar pCR rates. Prospective studies are essential for validating these findings.PMID:38509430 | DOI:10.1007/s12094-024-03430-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Ana Isabel Martin-Quesada Elisenda Llabres-Valent í Cristina Mar ía Montesdeoca-Godoy Carla Mart ín-Abreu Cristina Alem án-Sánchez Natalia Rodr íguez-Pérez Alicia Herrero-M árquez Josefina Cruz-Jurado Mar ía Hernández-Sosa Melody Marrero-Garc í Source Type: research
Quantitative proteomic analysis of HER2 protein expression in PDAC tumors
Clin Proteomics. 2024 Mar 20;21(1):24. doi: 10.1186/s12014-024-09476-7.ABSTRACTMetastatic pancreatic adenocarcinoma (PDAC) is the third leading cause of cancer-related death in the United States, with a 5-year survival rate of only 11%, necessitating identification of novel treatment paradigms. Tumor tissue specimens from patients with PDAC, breast cancer, and other solid tumor malignancies were collected and tumor cells were enriched using laser microdissection (LMD). Reverse phase protein array (RPPA) analysis was performed on enriched tumor cell lysates to quantify a 32-protein/phosphoprotein biomarker panel comprising ...
Source: Clinical Genitourinary Cancer - March 21, 2024 Category: Cancer & Oncology Authors: Jamie Randall Allison L Hunt Aratara Nutcharoen Laura Johnston Safae Chouraichi Hongkun Wang Arthur Winer Raymond Wadlow Jasmine Huynh Justin Davis Brian Corgiat Nicholas W Bateman John F Deeken Emanuel F Petricoin Thomas P Conrads Timothy L Cannon Source Type: research
