Paraneoplastic antibodies targeting intracellular antigens
Handb Clin Neurol. 2024;200:335-346. doi: 10.1016/B978-0-12-823912-4.00021-9.ABSTRACTAlthough they are relatively rare, the diagnosis of paraneoplastic neurologic syndromes (PNS) can be aided by the identification of neural autoantibodies in patients' serum and cerebrospinal fluid (CSF). They often clinically manifest as characteristic syndromes, including limbic encephalitis, opsoclonus-myoclonus syndrome, paraneoplastic cerebellar degeneration, and paraneoplastic encephalomyelitis. The antibodies are directed either toward intracellular targets, or epitopes on the cell surface. As compared to cell surface antibodies, int...
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Jenny J Linnoila Source Type: research
Paraneoplastic neurologic syndrome associated with gynecologic and breast malignancies
Handb Clin Neurol. 2024;200:409-417. doi: 10.1016/B978-0-12-823912-4.00014-1.ABSTRACTGynecologic and breast malignancies are the cancers most commonly associated with paraneoplastic neurologic syndromes, of which the foremost is Yo [Purkinje cell antibody, type 1 (PCA-1)] paraneoplastic cerebellar degeneration. Yo syndrome affects women in the sixth decade and manifests as a subacute severe cerebellar ataxia. The association of the typical clinical picture with the detection of Yo antibodies in a patient's serum or CSF defines the diagnosis. Yo syndrome is always associated with a cancer, and the search for the underlying ...
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Elise Peter J érôme Honnorat Virginie Desestret Source Type: research
Biopsy or Follow-up: AI Improves the Clinical Strategy of US BI-RADS 4A Breast Nodules Using a Convolutional Neural Network
CONCLUSION: DL was developed to discriminate US BI-RADS 4A lesions with a higher diagnostic power and more clinical net benefit than CE. Using DL may guide clinicians to make precise clinical decisions and avoid overtreatment of benign lesions.PMID:38494415 | DOI:10.1016/j.clbc.2024.02.003 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 17, 2024 Category: Cancer & Oncology Authors: Mei Yi Yue Lin Zehui Lin Ziting Xu Lian Li Ruobing Huang Weijun Huang Nannan Wang Yanling Zuo Nuo Li Dong Ni Yanyan Zhang Yingjia Li Source Type: research
Association between thyroid disorders and extra-thyroidal cancers, a review
Clin Transl Oncol. 2024 Mar 15. doi: 10.1007/s12094-024-03434-3. Online ahead of print.ABSTRACTThyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invasiveness, and angiogenesis are all aspects of cancer that are affected by the thyroid hormones T3 and T4, according to research conducted in animal models and in vitro experiments. The effects of thyroid hormones on cancer cells are mediated by many non-genomic mechanisms, one of which involves the activation of the plasma me...
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xin Jia Jingru Li Zongliang Jiang Source Type: research
Comparison of PD-L1 (22C3) Expression in Paired Primary and Metastatic Breast Carcinoma
CONCLUSION: Our study showed a decrease in PD-L1 expression and disconnected molecular features during breast cancer progression. Repeating PD-L1 IHC testing could be considered in some specific metastatic sites if primary tumors were negative. Further studies are needed to identify other predictive factors for immune checkpoint inhibitor (ICI) therapy in patients with breast carcinoma.PMID:38492995 | DOI:10.1016/j.clbc.2024.02.010 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xiao Huang Sarah A Anderson Gene P Siegal Shi Wei Shanrun Liu Jingyun Yang Puentes Roisin J Taylor Pickens Lei Huo Aysegul A Sahin Carlos Prieto Granada Shuojun Chen Source Type: research
Assessment of Postmastectomy Radiation Therapy Receipt by Age and Association With Outcomes in Women With Breast Cancer
CONCLUSION: Patients <50 years were more likely to undergo PMRT and to receive RNI to the internal mammary nodes but were also more likely to have other risk factors for recurrence that would warrant a PMRT recommendation. PMRT improved OS and RFS for all patients.PMID:38492996 | DOI:10.1016/j.clbc.2024.02.021 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Carolina E Fasola Elaina Graham Wei Sha Courtney R Schepel Sally J Trufan Anna Hecksher Richard L White Lejla Hadzikadic-Gusic Source Type: research
A Molecular Typing Method for Invasive Breast Cancer by Serum Raman Spectroscopy
CONCLUSION: Raman spectroscopy of serum samples can promptly and precisely detect the molecular subtype of invasive breast cancer, which has the potential for clinical value.PMID:38492997 | DOI:10.1016/j.clbc.2024.02.008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Jun Jiang Lintao Li Gang Yin Huaichao Luo Junjie Li Source Type: research
Association between thyroid disorders and extra-thyroidal cancers, a review
Clin Transl Oncol. 2024 Mar 15. doi: 10.1007/s12094-024-03434-3. Online ahead of print.ABSTRACTThyroid hormone has been shown to have both tumor-promoting and tumor-suppressing actions, which has led to significant debate over its involvement in the development of cancer. Proliferation, apoptosis, invasiveness, and angiogenesis are all aspects of cancer that are affected by the thyroid hormones T3 and T4, according to research conducted in animal models and in vitro experiments. The effects of thyroid hormones on cancer cells are mediated by many non-genomic mechanisms, one of which involves the activation of the plasma me...
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xin Jia Jingru Li Zongliang Jiang Source Type: research
Comparison of PD-L1 (22C3) Expression in Paired Primary and Metastatic Breast Carcinoma
CONCLUSION: Our study showed a decrease in PD-L1 expression and disconnected molecular features during breast cancer progression. Repeating PD-L1 IHC testing could be considered in some specific metastatic sites if primary tumors were negative. Further studies are needed to identify other predictive factors for immune checkpoint inhibitor (ICI) therapy in patients with breast carcinoma.PMID:38492995 | DOI:10.1016/j.clbc.2024.02.010 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Xiao Huang Sarah A Anderson Gene P Siegal Shi Wei Shanrun Liu Jingyun Yang Puentes Roisin J Taylor Pickens Lei Huo Aysegul A Sahin Carlos Prieto Granada Shuojun Chen Source Type: research
Assessment of Postmastectomy Radiation Therapy Receipt by Age and Association With Outcomes in Women With Breast Cancer
CONCLUSION: Patients <50 years were more likely to undergo PMRT and to receive RNI to the internal mammary nodes but were also more likely to have other risk factors for recurrence that would warrant a PMRT recommendation. PMRT improved OS and RFS for all patients.PMID:38492996 | DOI:10.1016/j.clbc.2024.02.021 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Carolina E Fasola Elaina Graham Wei Sha Courtney R Schepel Sally J Trufan Anna Hecksher Richard L White Lejla Hadzikadic-Gusic Source Type: research
A Molecular Typing Method for Invasive Breast Cancer by Serum Raman Spectroscopy
CONCLUSION: Raman spectroscopy of serum samples can promptly and precisely detect the molecular subtype of invasive breast cancer, which has the potential for clinical value.PMID:38492997 | DOI:10.1016/j.clbc.2024.02.008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Jun Jiang Lintao Li Gang Yin Huaichao Luo Junjie Li Source Type: research
An investigation of the effect of mindfulness-integrated cognitive behavior therapy on demoralization, body image, and sexual function in Iranian women with breast cancer: a randomized controlled trial
CONCLUSION: MICBT can be used in conjunction with pharmaceuticals and medical treatments to improve the psychological symptoms of women with breast cancer, according to this study's results. Trial registration (IRCT20160103025817N6). 2022-04-06.PMID:38485807 | PMC:PMC10940429 | DOI:10.1007/s00432-024-05655-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Mahboobeh Soleymani Moghadam Aliakbar Parvizifard Aliakbar Foroughi Seyed Mojtaba Ahmadi Negin Farshchian Source Type: research
The Relationship Between Tumor Budding and Patient's Survival in Breast Cancer
CONCLUSION: Our investigation revealed a significant statistical relationship between the number of tumor buds and patients' survival rate. So, this factor should be considered significant to help those patients increase their survival ratio.PMID:38487273 | PMC:PMC10938609 | DOI:10.1177/2632010X241235543 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Mohammad Ranaee Hossein Torabi Narges Azhganzad Kasra Shirini Akram Sadat Hosseini Karimollah Hajian Source Type: research
ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2
J Clin Invest. 2024 Jan 23;134(6):e171166. doi: 10.1172/JCI171166.ABSTRACTBreast cancer stem cells (BCSCs) mitigate oxidative stress to maintain their viability and plasticity. However, the regulatory mechanism of oxidative stress in BCSCs remains unclear. We recently found that the histone reader ZMYND8 was upregulated in BCSCs. Here, we showed that ZMYND8 reduced ROS and iron to inhibit ferroptosis in aldehyde dehydrogenase-high (ALDHhi) BCSCs, leading to BCSC expansion and tumor initiation in mice. The underlying mechanism involved a two-fold posttranslational regulation of nuclear factor erythroid 2-related factor 2 (N...
Source: Clinical Genitourinary Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Maowu Luo Lei Bao Yuanyuan Xue Ming Zhu Ashwani Kumar Chao Xing Jennifer E Wang Yingfei Wang Weibo Luo Source Type: research
The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
Clin Exp Metastasis. 2024 Mar 15. doi: 10.1007/s10585-024-10269-3. Online ahead of print.ABSTRACTAs a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many other aspects of cellular function. Once thought to be irreparably defective, mitochondrial function in cancer cells has found renewed interest, from suggested potential clinical biomarkers to mitochondria-targeting therapies. Here, we will focus on the effect of mitochondria movement on breast cancer progression. Mitochondria move both within the cell, such as to localize to areas ...
Source: Clinical Genitourinary Cancer - March 15, 2024 Category: Cancer & Oncology Authors: Sarah Libring Emily D Berestesky Cynthia A Reinhart-King Source Type: research
