Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ
CONCLUSION: Our findings suggest that cost-effective and clinically optimal treatment strategies are RT alone for standard-risk DCIS and observation for good-risk DCIS, with personalization on the basis of patient age and preference for RT. Hormonal therapy is likely suboptimal for most patients with DCIS.PMID:34019456 | DOI:10.1200/JCO.21.00831 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 21, 2021 Category: Cancer & Oncology Authors: Apar Gupta Sachin R Jhawar Mutlay Sayan Zeinab A Yehia Bruce G Haffty James B Yu Shi-Yi Wang Source Type: research

Deciphering the temporal heterogeneity of cancer-associated fibroblast subpopulations in breast cancer
CONCLUSION: We demonstrate that multiple subpopulations of CAFs co-exist in murine triple negative breast cancer, and that the abundance and dynamics for each marker differ depending on tumour type and time. Our results form the foundation needed to isolate and characterise specific CAF populations, and ultimately provide an opportunity to therapeutically target specific CAF subpopulations.PMID:34016130 | DOI:10.1186/s13046-021-01944-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 21, 2021 Category: Cancer & Oncology Authors: Freja Albjerg Venning Kamilla Westarp Zornhagen Lena Wullkopf Jonas Sj ölund Carmen Rodriguez-Cupello Pontus Kjellman Mikkel Morsing Morteza Chalabi Hajkarim Kyoung Jae Won Janine Terra Erler Chris Denis Madsen Source Type: research

Sex-based dimorphism of anticancer immune response and molecular mechanisms of immune evasion
CONCLUSIONS: We demonstrated meaningful sex-based differences of anticancer immune response and immune evasion mechanisms, that may be exploited to improve immunotherapy efficacy for both women and men.PMID:34016641 | DOI:10.1158/1078-0432.CCR-21-0136 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 21, 2021 Category: Cancer & Oncology Authors: Fabio Conforti Laura Pala Eleonora Pagan Vincenzo Bagnardi Tommaso De Pas Paola Queirolo Elisabetta Pennacchioli Chiara Catania Emilia Cocorocchio Pier Francesco Ferrucci Maristella Saponara Gianmarco Orsolini Paola Zagami Eleonora Nicolo Filippo De Marin Source Type: research

Steroid ligands, the forgotten triggers of nuclear receptor action; implications for acquired resistance to endocrine therapy
Clin Cancer Res. 2021 May 20:clincanres.4135.2020. doi: 10.1158/1078-0432.CCR-20-4135. Online ahead of print.ABSTRACTPURPOSE: There is strong epidemiological evidence which indicates that estrogens may not be the sole steroid drivers of breast cancer. We hypothesize that abundant adrenal androgenic steroid precursors, acting via the androgen receptor (AR), promote an endocrine resistant breast cancer phenotype.EXPERIMENTAL DESIGN: AR was evaluated in a primary breast cancer tissue-microarray (n=844). Androstenedione (4AD) levels were evaluated in serum samples (n=42) from hormone receptor positive, post-menopausal breast c...
Source: Clinical Genitourinary Cancer - May 21, 2021 Category: Cancer & Oncology Authors: Rachel Bleach Stephen F Madden James Hawley Sara Charmsaz Cigdem Selli Katherine M Sheehan Leonie S Young Andrew H Sims Pavel Soucek Arnold D Hill Marie McIlroy Source Type: research

Cost-Effectiveness of Adjuvant Treatment for Ductal Carcinoma In Situ
CONCLUSION: Our findings suggest that cost-effective and clinically optimal treatment strategies are RT alone for standard-risk DCIS and observation for good-risk DCIS, with personalization on the basis of patient age and preference for RT. Hormonal therapy is likely suboptimal for most patients with DCIS.PMID:34019456 | DOI:10.1200/JCO.21.00831 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 21, 2021 Category: Cancer & Oncology Authors: Apar Gupta Sachin R Jhawar Mutlay Sayan Zeinab A Yehia Bruce G Haffty James B Yu Shi-Yi Wang Source Type: research

Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer
CONCLUSIONS: These data suggest nuclear FGFR1 contributes to endocrine resistance by modulating gene transcription in ER+ breast cancer. Nuclear FGFR1 activity was unaffected by FGFR TKIs, thus supporting the development of treatment strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.PMID:34011560 | DOI:10.1158/1078-0432.CCR-20-3905 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 20, 2021 Category: Cancer & Oncology Authors: Alberto Servetto Rahul Kollipara Luigi Formisano Chang-Ching Lin Kyung-Min Lee Dhivya R Sudhan Paula I Gonzalez-Ericsson Sumanta Chatterjee Angel Guerrero-Zotano Saurabh Mendiratta Hiroaki Akamatsu Nicholas James Roberto Bianco Ariella B Hanker Ralf Kittl Source Type: research

Correction to: Comprehensive study for BRCA1 and BRCA2 entire coding regions in breast cancer
Clin Transl Oncol. 2021 May 20. doi: 10.1007/s12094-021-02643-4. Online ahead of print.NO ABSTRACTPMID:34014551 | DOI:10.1007/s12094-021-02643-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 20, 2021 Category: Cancer & Oncology Authors: A S Algebaly R S Suliman W S Al-Qahtani Source Type: research

Nuclear FGFR1 regulates gene transcription and promotes antiestrogen resistance in ER+ breast cancer
CONCLUSIONS: These data suggest nuclear FGFR1 contributes to endocrine resistance by modulating gene transcription in ER+ breast cancer. Nuclear FGFR1 activity was unaffected by FGFR TKIs, thus supporting the development of treatment strategies to inhibit nuclear FGFR1 in ER+/FGFR1 overexpressing breast cancer.PMID:34011560 | DOI:10.1158/1078-0432.CCR-20-3905 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 20, 2021 Category: Cancer & Oncology Authors: Alberto Servetto Rahul Kollipara Luigi Formisano Chang-Ching Lin Kyung-Min Lee Dhivya R Sudhan Paula I Gonzalez-Ericsson Sumanta Chatterjee Angel Guerrero-Zotano Saurabh Mendiratta Hiroaki Akamatsu Nicholas James Roberto Bianco Ariella B Hanker Ralf Kittl Source Type: research

The Impact of Genomic Profiling on Adjuvant Therapy Recommendation in Postmenopausal Women with ER-Positive, T1-2 Breast Cancer: Can Genomic Profiling Eliminate the Need for Sentinel Lymph Node Biopsy?
CONCLUSION: SLNB changed the recommendation for/against chemotherapy, or the chemotherapy regiment recommended, in 4.8% of postmenopausal women with early-stage, ER-positive/HER2-negative breast cancer, and sonographically negative axilla when using RS> 25 or N2-3 disease as an indication for chemotherapy. Preoperative genomic profiling can guide de-escalation of axillary surgery.PMID:34006481 | DOI:10.1016/j.clbc.2021.02.011 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 19, 2021 Category: Cancer & Oncology Authors: Elaine Lee Carol Tweed Charles Mylander Laura Martino Martin Rosman Nicholas Huerta Kip Waite Lorraine Tafra Rubie Sue Jackson Source Type: research

Melanoma and Li-Fraumeni syndrome - family history not essential for screening recommendation
Clin Exp Dermatol. 2021 May 19. doi: 10.1111/ced.14748. Online ahead of print.ABSTRACTLi-Fraumeni Syndrome (LFS) is a recognised cancer predisposition syndrome associated with early onset of multiple cancer types. It was first described in 1969 following the identification of two soft tissue sarcomas in five families with the index case presenting with rhabdomyosarcoma in childhood.1 The tumour spectrum classically includes a range of soft tissue sarcomas, bone tumours, haematological malignancies, breast cancer and adrenal cortical cancer.PMID:34008262 | DOI:10.1111/ced.14748 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 19, 2021 Category: Cancer & Oncology Authors: H Regan P Marren Source Type: research

Breast Sarcomas, Phyllodes Tumors, and Desmoid Tumors: Epidemiology, Diagnosis, Staging, and Histology-Specific Management Considerations
Am Soc Clin Oncol Educ Book. 2021 Mar;41:390-404. doi: 10.1200/EDBK_321341.ABSTRACTBreast sarcomas arise from connective tissues of the breast and account for fewer than 1% of all breast malignancies. They can be subclassified as primary breast sarcomas, which arise de novo and are histologically diverse, and secondary breast sarcomas, which arise as a result of radiation or lymphedema and are most commonly angiosarcomas. Two other connective tissue neoplasms that occur within the breast include phyllodes tumors and desmoid tumors, which exhibit a spectrum of behaviors. Malignant phyllodes tumors are biologically similar t...
Source: Clinical Genitourinary Cancer - May 19, 2021 Category: Cancer & Oncology Authors: George Z Li Chandrajit P Raut Kelly K Hunt Mary Feng Rashmi Chugh Source Type: research

NEFM DNA methylation correlates with immune infiltration and survival in breast cancer
CONCLUSIONS: NEFM low-expression/DNA methylation correlates with poor prognosis. NEFM expression positively correlates with macrophage infiltration. NEFM DNA methylation strongly negatively correlates with immune infiltration in BRCA. Our study highlights novel potential functions of NEFM expression/DNA methylation in regulation of tumor immune microenvironment.PMID:34001208 | DOI:10.1186/s13148-021-01096-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Dandan Li Wenhao Zhao Xinyu Zhang Hanning Lv Chunhong Li Lichun Sun Source Type: research

Relationship Between the Neutrophil to Lymphocyte Ratio, Stromal Tumor-infiltrating Lymphocytes, and the Prognosis and Response to Neoadjuvant Chemotherapy in Triple-negative Breast Cancer
Clin Breast Cancer. 2021 Apr 14:S1526-8209(21)00072-0. doi: 10.1016/j.clbc.2021.04.004. Online ahead of print.ABSTRACTINTRODUCTION: Neutrophil to lymphocyte ratio (NLR) and stromal tumor-infiltrating lymphocytes (sTILs) are correlated with triple-negative breast cancer (TNBC) patient prognosis. However, there has been insufficient research regarding the relationship between systemic and local inflammatory states in patients with TNBC, and their effects on neoadjuvant chemotherapy (NAC) efficacy.METHODS: The clinical data of 395 patients with TNBC admitted from January 2010 to December 2018 were collected. The Pearson χ...
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Jian Pang Haiyan Zhou Xue Dong Shouman Wang Zhi Xiao Source Type: research

Factors Associated With Surgical Modality Following Neoadjuvant Chemotherapy in Patients with Breast Cancer
This study aimed to identify factors affecting the choice of surgical modality following neoadjuvant chemotherapy (NAC) in patients with breast cancer in northwest China.PATIENTS AND METHODS: Patients who underwent mastectomy or BCS after NAC for invasive breast cancer from January 2013 to December 2017 were enrolled in the study. Single-factor and multivariate logistic regression analyses were applied to identify the association between the type of surgery and demographic characteristics or clinical pathological factors of patients.RESULTS: This study enrolled 916 patients. Among them, 191 patients (20.9%) and 725 patient...
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Xin Li Changjiao Yan Jingjing Xiao Xin Xu Yike Li Xinxin Wen Hongliang Wei Source Type: research

Diabetic mastopathy in an elderly woman misdiagnosed as breast cancer: A case report and review of the literature
CONCLUSION: The diagnosis of diabetic mastopathy in elderly patients with painless breast masses is difficult to distinguish from breast cancer, and its imaging manifestations are not specific.PMID:34002158 | PMC:PMC8107902 | DOI:10.12998/wjcc.v9.i14.3458 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Xiao-Xiao Chen Shi-Jun Shao Hua Wan Source Type: research

Diversity of interpretations of the concept "patient-centered care for breast cancer patients"; a scoping review of current literature
CONCLUSIONS: We propose, contrary to previous efforts to define "patient-centered care" more accurately, to embrace the heterogeneity of the concept and apply "patient-centered care" as an umbrella-term for all healthcare that intends to contribute to the acknowledgement of the person in the patient. For the justification of measures to realize patient-centered care for breast cancer patients, instead of a mere contribution to the abstract concept, we insist on the demonstration of desirable real-world effects.PMID:34002460 | DOI:10.1111/jep.13584 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Elise Pel Ingeborg Engelberts Maartje Schermer Source Type: research

EGFR mutation analysis on circulating free DNA in NSCLC: a single-center experience
CONCLUSION: EGFR mutation status can be assessed using cfDNA for routine purposes and longitudinal assessment of plasma mutation is an easy approach to monitor the therapeutic response or resistance onset.PMID:34003366 | DOI:10.1007/s00432-021-03658-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Anna Ianza A Di Chicco C Biagi F Giudici A Dicorato A Guglielmi F Variola S Tomasi G Roviello D Generali F Zanconati Source Type: research

Updated Standardized Definitions for Efficacy End Points (STEEP) in Adjuvant Breast Cancer Clinical Trials: STEEP Version 2.0
CONCLUSION: We recommend an additional end point, invasive breast cancer-free survival, which includes all invasive disease-free survival events except second nonbreast primary cancers. This end point should be considered for trials in which the toxicities of agents are well-known and where the risk of second primary cancer is small. Additionally, we provide end point recommendations for local therapy trials, low-risk populations, noninferiority trials, and trials incorporating patient-reported outcomes.PMID:34003702 | DOI:10.1200/JCO.20.03613 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Sara M Tolaney Elizabeth Garrett-Mayer Julia White Victoria S Blinder Jared C Foster Laleh Amiri-Kordestani E Shelley Hwang Judith M Bliss Eileen Rakovitch Jane Perlmutter Patricia A Spears Elizabeth Frank Nadine M Tung Anthony D Elias David Cameron Neeli Source Type: research

NEFM DNA methylation correlates with immune infiltration and survival in breast cancer
CONCLUSIONS: NEFM low-expression/DNA methylation correlates with poor prognosis. NEFM expression positively correlates with macrophage infiltration. NEFM DNA methylation strongly negatively correlates with immune infiltration in BRCA. Our study highlights novel potential functions of NEFM expression/DNA methylation in regulation of tumor immune microenvironment.PMID:34001208 | DOI:10.1186/s13148-021-01096-4 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Dandan Li Wenhao Zhao Xinyu Zhang Hanning Lv Chunhong Li Lichun Sun Source Type: research

Relationship Between the Neutrophil to Lymphocyte Ratio, Stromal Tumor-infiltrating Lymphocytes, and the Prognosis and Response to Neoadjuvant Chemotherapy in Triple-negative Breast Cancer
Clin Breast Cancer. 2021 Apr 14:S1526-8209(21)00072-0. doi: 10.1016/j.clbc.2021.04.004. Online ahead of print.ABSTRACTINTRODUCTION: Neutrophil to lymphocyte ratio (NLR) and stromal tumor-infiltrating lymphocytes (sTILs) are correlated with triple-negative breast cancer (TNBC) patient prognosis. However, there has been insufficient research regarding the relationship between systemic and local inflammatory states in patients with TNBC, and their effects on neoadjuvant chemotherapy (NAC) efficacy.METHODS: The clinical data of 395 patients with TNBC admitted from January 2010 to December 2018 were collected. The Pearson χ...
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Jian Pang Haiyan Zhou Xue Dong Shouman Wang Zhi Xiao Source Type: research

Factors Associated With Surgical Modality Following Neoadjuvant Chemotherapy in Patients with Breast Cancer
This study aimed to identify factors affecting the choice of surgical modality following neoadjuvant chemotherapy (NAC) in patients with breast cancer in northwest China.PATIENTS AND METHODS: Patients who underwent mastectomy or BCS after NAC for invasive breast cancer from January 2013 to December 2017 were enrolled in the study. Single-factor and multivariate logistic regression analyses were applied to identify the association between the type of surgery and demographic characteristics or clinical pathological factors of patients.RESULTS: This study enrolled 916 patients. Among them, 191 patients (20.9%) and 725 patient...
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Xin Li Changjiao Yan Jingjing Xiao Xin Xu Yike Li Xinxin Wen Hongliang Wei Source Type: research

Diabetic mastopathy in an elderly woman misdiagnosed as breast cancer: A case report and review of the literature
CONCLUSION: The diagnosis of diabetic mastopathy in elderly patients with painless breast masses is difficult to distinguish from breast cancer, and its imaging manifestations are not specific.PMID:34002158 | PMC:PMC8107902 | DOI:10.12998/wjcc.v9.i14.3458 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Xiao-Xiao Chen Shi-Jun Shao Hua Wan Source Type: research

Diversity of interpretations of the concept "patient-centered care for breast cancer patients"; a scoping review of current literature
CONCLUSIONS: We propose, contrary to previous efforts to define "patient-centered care" more accurately, to embrace the heterogeneity of the concept and apply "patient-centered care" as an umbrella-term for all healthcare that intends to contribute to the acknowledgement of the person in the patient. For the justification of measures to realize patient-centered care for breast cancer patients, instead of a mere contribution to the abstract concept, we insist on the demonstration of desirable real-world effects.PMID:34002460 | DOI:10.1111/jep.13584 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Elise Pel Ingeborg Engelberts Maartje Schermer Source Type: research

EGFR mutation analysis on circulating free DNA in NSCLC: a single-center experience
CONCLUSION: EGFR mutation status can be assessed using cfDNA for routine purposes and longitudinal assessment of plasma mutation is an easy approach to monitor the therapeutic response or resistance onset.PMID:34003366 | DOI:10.1007/s00432-021-03658-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Anna Ianza A Di Chicco C Biagi F Giudici A Dicorato A Guglielmi F Variola S Tomasi G Roviello D Generali F Zanconati Source Type: research

Updated Standardized Definitions for Efficacy End Points (STEEP) in Adjuvant Breast Cancer Clinical Trials: STEEP Version 2.0
CONCLUSION: We recommend an additional end point, invasive breast cancer-free survival, which includes all invasive disease-free survival events except second nonbreast primary cancers. This end point should be considered for trials in which the toxicities of agents are well-known and where the risk of second primary cancer is small. Additionally, we provide end point recommendations for local therapy trials, low-risk populations, noninferiority trials, and trials incorporating patient-reported outcomes.PMID:34003702 | DOI:10.1200/JCO.20.03613 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 18, 2021 Category: Cancer & Oncology Authors: Sara M Tolaney Elizabeth Garrett-Mayer Julia White Victoria S Blinder Jared C Foster Laleh Amiri-Kordestani E Shelley Hwang Judith M Bliss Eileen Rakovitch Jane Perlmutter Patricia A Spears Elizabeth Frank Nadine M Tung Anthony D Elias David Cameron Neeli Source Type: research

Endocrine therapy with accelerated Partial breast irradiatiOn or exclusive ultra-accelerated Partial breast irradiation for women aged 60 years with Early-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial
CONCLUSION: To investigate de-escalation adjuvant treatment for elderly breast cancer patients, we have defined a road map for testing more convenient strategies. This EPOPE phase 3 randomized trial is supported by the GEC-ESTRO breast cancer working group.PMID:33997321 | PMC:PMC8102143 | DOI:10.1016/j.ctro.2021.04.005 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 17, 2021 Category: Cancer & Oncology Authors: Jean-Michel Hannoun-Levi Emmanuel Chamorey Rabia Boulahssass Csaba Polgar Vratislav Strnad Breast Cancer Working Group of the GEC-ESTRO Source Type: research

Exposure-Response Relationships in Patients With HER2-Positive Metastatic Breast Cancer and Other Solid Tumors Treated With Trastuzumab Deruxtecan
Clin Pharmacol Ther. 2021 May 17. doi: 10.1002/cpt.2291. Online ahead of print.ABSTRACTTrastuzumab deruxtecan (T-DXd) is a HER2-targeting antibody-drug conjugate composed of a novel enzyme-cleavable linker and membrane-permeable topoisomerase I inhibitor payload. T-DXd has been approved for HER2-positive metastatic breast cancer (BC) and for HER2-positive metastatic gastric cancer. The approval in BC was based on results from the DESTINY-Breast01 (U201; NCT03248492) and J101 (NCT02564900) trials. Here we present dose justification for the approved 5.4 mg/kg every-3-weeks (Q3W) dose based on exposure-efficacy evaluated in H...
Source: Clinical Genitourinary Cancer - May 17, 2021 Category: Cancer & Oncology Authors: Ophelia Yin Hiroji Iwata Chia-Chi Lin Kenji Tamura Junichiro Watanabe Russ Wada Helen Kastrissios Malaz AbuTarif Tushar Garimella Caleb Lee Lin Zhang Javad Shahidi Frank LaCreta Source Type: research

Updated Results of TBCRC026: Phase II Trial Correlating Standardized Uptake Value With Pathological Complete Response to Pertuzumab and Trastuzumab in Breast Cancer
CONCLUSION: Although the primary objective was not met, early changes in SULmax predict response to PT in estrogen receptor-negative and HER2-positive breast cancer. Once optimized, this quantitative imaging strategy may facilitate tailoring of therapy in this setting.PMID:33999652 | DOI:10.1200/JCO.21.00280 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 17, 2021 Category: Cancer & Oncology Authors: Roisin M Connolly Jeffrey P Leal Lilja Solnes Chiung-Yu Huang Ashley Carpenter Katy Gaffney Vandana Abramson Lisa A Carey Minetta C Liu Mothaffar Rimawi Jennifer Specht Anna Maria Storniolo Vicente Valero Christos Vaklavas Ian E Krop Eric P Winer Melissa Source Type: research

Endocrine therapy with accelerated Partial breast irradiatiOn or exclusive ultra-accelerated Partial breast irradiation for women aged 60 years with Early-stage breast cancer (EPOPE): The rationale for a GEC-ESTRO randomized phase III-controlled trial
CONCLUSION: To investigate de-escalation adjuvant treatment for elderly breast cancer patients, we have defined a road map for testing more convenient strategies. This EPOPE phase 3 randomized trial is supported by the GEC-ESTRO breast cancer working group.PMID:33997321 | PMC:PMC8102143 | DOI:10.1016/j.ctro.2021.04.005 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 17, 2021 Category: Cancer & Oncology Authors: Jean-Michel Hannoun-Levi Emmanuel Chamorey Rabia Boulahssass Csaba Polgar Vratislav Strnad Breast Cancer Working Group of the GEC-ESTRO Source Type: research

Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1
CONCLUSIONS: SRSF1 exerts oncogenic roles in BRCA partially by regulating the AS of PTPMT1, which could be a therapeutic target candidate in BRCA and a prognostic factor in HR+ BRCA patient.PMID:33992102 | DOI:10.1186/s13046-021-01978-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 16, 2021 Category: Cancer & Oncology Authors: Jun-Xian Du Yi-Hong Luo Si-Jia Zhang Biao Wang Cong Chen Gui-Qi Zhu Ping Zhu Cheng-Zhe Cai Jing-Lei Wan Jia-Liang Cai Shi-Ping Chen Zhi Dai Wei Zhu Source Type: research

Real-world Data on First-line Systemic Therapy for Hormone Receptor-positive HER2-negative Metastatic Breast Cancer: A Trend Shift in the Era of CDK 4/6 Inhibitors
Clin Breast Cancer. 2021 Apr 20:S1526-8209(21)00071-9. doi: 10.1016/j.clbc.2021.04.003. Online ahead of print.ABSTRACTHormone receptor-positive (HR+) human epidermal growth factor receptor-2 negative (HER2-) tumors represent the most common subtype of metastatic breast cancer (MBC). International guidelines clearly state that endocrine therapy (ET) should be considered the preferred first-line therapy for these patients in the absence of very symptomatic visceral disease or evidence of endocrine resistance. Nonetheless compliance with guidelines significantly vary worldwide for many different reasons. Historically, a subst...
Source: Clinical Genitourinary Cancer - May 16, 2021 Category: Cancer & Oncology Authors: Gustavo Werutsky Tom ás Reinert Mahira Lopes Rosa Carlos Henrique Barrios Source Type: research

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress
CONCLUSIONS: Our study indicates that SLC6A8-mediated creatine accumulation plays an important role in promoting TNBC progression, and may provide a potential therapeutic strategy option for treatment of SLC6A8 high expressed TNBC.PMID:33990217 | DOI:10.1186/s13046-021-01933-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 15, 2021 Category: Cancer & Oncology Authors: Qiao Li Manran Liu Yan Sun Ting Jin Pengpeng Zhu Xueying Wan Yixuan Hou Gang Tu Source Type: research

Prognostic relevance of Ki67 expression in primary male breast cancer: determination of cut-off points by different evaluation methods and statistical examinations
In this study, we aimed to evaluate adequate examination methods and reliable cut-off points for Ki67 to assess the highest prognostic value for patient's overall survival (OS).METHODS: In this multicentric retrospective study, histological specimens were obtained from 104 male patients who were diagnosed and treated for primary invasive breast cancer. We applied three methods of Ki67 analysis: Tumor average scoring (TA), tumor border scoring (TB) and hot-spot scoring (HS). Calculated Ki67 cut-off points for each method were assessed as a threshold for patients' overall survival (OS).RESULTS: Ki67 cut-off points were 13.5 ...
Source: Clinical Genitourinary Cancer - May 15, 2021 Category: Cancer & Oncology Authors: Melanie Erices-Leclercq Sabine Lubig Frank F örster Robert F örster Stefan Baldus Christian Rudlowski Lars Schr öder Source Type: research

SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress
CONCLUSIONS: Our study indicates that SLC6A8-mediated creatine accumulation plays an important role in promoting TNBC progression, and may provide a potential therapeutic strategy option for treatment of SLC6A8 high expressed TNBC.PMID:33990217 | DOI:10.1186/s13046-021-01933-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 15, 2021 Category: Cancer & Oncology Authors: Qiao Li Manran Liu Yan Sun Ting Jin Pengpeng Zhu Xueying Wan Yixuan Hou Gang Tu Source Type: research

Prognostic relevance of Ki67 expression in primary male breast cancer: determination of cut-off points by different evaluation methods and statistical examinations
In this study, we aimed to evaluate adequate examination methods and reliable cut-off points for Ki67 to assess the highest prognostic value for patient's overall survival (OS).METHODS: In this multicentric retrospective study, histological specimens were obtained from 104 male patients who were diagnosed and treated for primary invasive breast cancer. We applied three methods of Ki67 analysis: Tumor average scoring (TA), tumor border scoring (TB) and hot-spot scoring (HS). Calculated Ki67 cut-off points for each method were assessed as a threshold for patients' overall survival (OS).RESULTS: Ki67 cut-off points were 13.5 ...
Source: Clinical Genitourinary Cancer - May 15, 2021 Category: Cancer & Oncology Authors: Melanie Erices-Leclercq Sabine Lubig Frank F örster Robert F örster Stefan Baldus Christian Rudlowski Lars Schr öder Source Type: research

The Lack of Association between Plant-Based Dietary Pattern and Breast Cancer: a Hospital-Based Case-Control Study
Clin Nutr Res. 2021 Apr 26;10(2):115-126. doi: 10.7762/cnr.2021.10.2.115. eCollection 2021 Apr.ABSTRACTOur purpose was to assess the association between plant-based dietary patterns and breast cancer (BrCa) among Iranian women. This hospital-based case-control study included 150 newly diagnosed BrCa cases and 150 age-matched controls from the Cancer Research Center, Imam Khomeini hospital, Iran. Three indices of a plant-based diet were first calculated: plant-based diet index (PDI), the healthy PDI (hPDI), and the unhealthy PDI (uPDI). In the overall PDI, all plant foods scored positively. In hPDI and uPDI, healthy and les...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Nastaran Payandeh Hossein Shahinfar Mohammad Reza Amini Alireza Jafari Maryam Safabakhsh Hossein Imani Sakineh Shab-Bidar Source Type: research

Automated NLP Extraction of Clinical Rationale for Treatment Discontinuation in Breast Cancer
JCO Clin Cancer Inform. 2021 May;5:550-560. doi: 10.1200/CCI.20.00139.ABSTRACTPURPOSE: Key oncology end points are not routinely encoded into electronic medical records (EMRs). We assessed whether natural language processing (NLP) can abstract treatment discontinuation rationale from unstructured EMR notes to estimate toxicity incidence and progression-free survival (PFS).METHODS: We constructed a retrospective cohort of 6,115 patients with early-stage and 701 patients with metastatic breast cancer initiating care at Memorial Sloan Kettering Cancer Center from 2008 to 2019. Each cohort was divided into training (70%), vali...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Matthew S Alkaitis Monica N Agrawal Gregory J Riely Pedram Razavi David Sontag Source Type: research

Challenges in Adjuvant Therapy for Premenopausal Women Diagnosed With Luminal Breast Cancers
Am Soc Clin Oncol Educ Book. 2021 Mar;41:1-15. doi: 10.1200/EDBK_320595.ABSTRACTMore than 90% of women with newly diagnosed breast cancer present with stage I to III disease and, with optimal multidisciplinary therapy, are likely to survive their disease. Of these patients, 70% are hormone receptor-positive and candidates for adjuvant endocrine therapy. The adoption of cumulatively better adjuvant treatments contributed to improved outcomes in patients with hormone receptor-positive, early-stage breast cancer. Premenopausal women with hormone receptor-positive breast cancer often present with complex disease and have infer...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Ines Vaz-Luis Prudence A Francis Antonio Di Meglio Vered Stearns Source Type: research

Harnessing Nutrition and Physical Activity for Breast Cancer Prevention and Control to Reduce Racial/Ethnic Cancer Health Disparities
Am Soc Clin Oncol Educ Book. 2021 Mar;41:1-17. doi: 10.1200/EDBK_321315.ABSTRACTThere are well-known racial/ethnic disparities in the prevalence of obesity and physical inactivity, as well as breast cancer risk and survival. However, most of the current scientific evidence that serves as a foundation for nutrition and physical activity guidelines is based on studies conducted in predominantly non-Hispanic White populations. Similarly, exercise, diet, or lifestyle intervention trials for breast cancer prevention and survivorship are scarce in racial/ethnic minority populations. We review the current evidence for racial/ethn...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Elisa V Bandera Catherine M Alfano Bo Qin Dong-Woo Kang Ciar án P Friel Christina Dieli-Conwright Source Type: research

The evolving role of immune checkpoint inhibitors in the treatment of triple-negative breast cancer
Clin Adv Hematol Oncol. 2021 May;19(5):305-315.ABSTRACTTriple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer for which chemotherapy had been the only active treatment option once metastatic disease developed. Immune checkpoint inhibitors (ICIs) are now available to treat patients with advanced TNBC who have programmed cell death ligand 1 (PD-L1)-positive tumors; these agents have been shown to improve clinical outcomes. Additionally, long-term disease control can be achieved in a subset of patients. Continued investigations of ICIs and optimal combinations with chemotherapy and targeted agents to e...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Meghan Steiner Antoinette R Tan Source Type: research

The Lack of Association between Plant-Based Dietary Pattern and Breast Cancer: a Hospital-Based Case-Control Study
Clin Nutr Res. 2021 Apr 26;10(2):115-126. doi: 10.7762/cnr.2021.10.2.115. eCollection 2021 Apr.ABSTRACTOur purpose was to assess the association between plant-based dietary patterns and breast cancer (BrCa) among Iranian women. This hospital-based case-control study included 150 newly diagnosed BrCa cases and 150 age-matched controls from the Cancer Research Center, Imam Khomeini hospital, Iran. Three indices of a plant-based diet were first calculated: plant-based diet index (PDI), the healthy PDI (hPDI), and the unhealthy PDI (uPDI). In the overall PDI, all plant foods scored positively. In hPDI and uPDI, healthy and les...
Source: Clinical Genitourinary Cancer - May 14, 2021 Category: Cancer & Oncology Authors: Nastaran Payandeh Hossein Shahinfar Mohammad Reza Amini Alireza Jafari Maryam Safabakhsh Hossein Imani Sakineh Shab-Bidar Source Type: research

Clinical Contribution of Next-Generation Sequencing Multigene Panel Testing for BRCA Negative High-Risk Patients With Breast Cancer
CONCLUSION: This is one of the largest study from Turkey to investigate the mutation spectrum in non-BRCA hereditary breast cancer susceptibility genes. A multigene panel test increased the likelihood of identifying a molecular diagnosis in patients with BRCA 1/2-negative breast cancer at risk for a hereditary breast cancer syndrome. More studies are needed to enable the clinical interpretation of these P/LP variants in hereditary patients with breast cancer.PMID:33980423 | DOI:10.1016/j.clbc.2021.04.002 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 13, 2021 Category: Cancer & Oncology Authors: Asl ı Ece Solmaz Levent Yeniay Erhan G ökmen Osman Zekio ğlu Ayfer Haydaro ğlu I şıl Bilgen Ferda Özkınay H üseyin Onay Source Type: research

Visualization of intra-tumor pharmacokinetics of [fam-] trastuzumab deruxtecan (DS-8201a) in HER2 heterogeneous model using phosphor-integrated dots imaging analysis
CONCLUSIONS: Our results suggest that T-DXd is distributed to tumor tissues via trastuzumab in a HER2-dependent manner and then to adjacent HER2-negative areas. We successfully visualized the intra-tumor distribution of T-DXd and its mechanism of action, the so-called "bystander effect".PMID:33980613 | DOI:10.1158/1078-0432.CCR-21-0397 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 13, 2021 Category: Cancer & Oncology Authors: Mikiko Suzuki Shigehiro Yagishita Kiyoshi Sugihara Yusuke Ogitani Tadaaki Nishikawa Mayu Ohuchi Takashi Teishikata Takahiro Jikoh Yasushi Yatabe Kan Yonemori Kenji Tamura Kosei Hasegawa Akinobu Hamada Source Type: research

Feasibility of breast radiation therapy in a Fanconi Anemia patient diagnosed with breast cancer: A case report and review of literature
Clin Transl Radiat Oncol. 2021 Apr 9;28:129-132. doi: 10.1016/j.ctro.2021.04.001. eCollection 2021 May.ABSTRACTFanconi Anemia (FA) is a rare inherited autosomal recessive disease that results in impaired double stranded DNA repair. This leads to both increased susceptibility to various cancers, as well as hypersensitivity to radiotherapy and systemic therapy; thus, increasing the complexity of oncological treatment paradigm. Here, we present an FA patient who initially developed invasive breast cancer for which she received breast conserving treatment with no significant treatment related toxicity. This was followed by a d...
Source: Clinical Genitourinary Cancer - May 13, 2021 Category: Cancer & Oncology Authors: Neha Hafeez Hima Bindu Musunuru Andrew Keller Sushil Beriwal Source Type: research

Diagnostic Values of 8 Different Imaging Modalities for Preoperative Detection of Axillary Lymph Node Metastasis of Breast Cancer: A Bayesian Network Meta-analysis
CONCLUSION: Elastography showed the highest SUCRA values. Seven imaging modalities showed the complementary diagnostic roles for preoperative detection of axillary LN metastasis in patients with breast cancer, except mammography.PMID:33979099 | DOI:10.1097/COC.0000000000000831 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 12, 2021 Category: Cancer & Oncology Authors: Keunyoung Kim Sung-Ryul Shim Seong-Jang Kim Source Type: research

Diagnostic Values of 8 Different Imaging Modalities for Preoperative Detection of Axillary Lymph Node Metastasis of Breast Cancer: A Bayesian Network Meta-analysis
CONCLUSION: Elastography showed the highest SUCRA values. Seven imaging modalities showed the complementary diagnostic roles for preoperative detection of axillary LN metastasis in patients with breast cancer, except mammography.PMID:33979099 | DOI:10.1097/COC.0000000000000831 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 12, 2021 Category: Cancer & Oncology Authors: Keunyoung Kim Sung-Ryul Shim Seong-Jang Kim Source Type: research

Congenital bilateral cryptorchidism in an infant conceived after maternal breast cancer treatment: A case report
CONCLUSION: HER2 overexpression, positivity for EGFR, Ki67, and ER, and PR negativity are associated with a poor prognosis in breast cancer. While no link has been established statistically between treatment for breast cancer and cryptorchidism in a subsequent pregnancy, this case suggests the possibility that ERβ and gene mutations may be contributing factors.PMID:33969078 | PMC:PMC8058667 | DOI:10.12998/wjcc.v9.i12.2923 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 10, 2021 Category: Cancer & Oncology Authors: Wei-Kai Hu Jing Liu Rui-Xia Liu Xiao-Wei Liu Cheng-Hong Yin Source Type: research

Congenital bilateral cryptorchidism in an infant conceived after maternal breast cancer treatment: A case report
CONCLUSION: HER2 overexpression, positivity for EGFR, Ki67, and ER, and PR negativity are associated with a poor prognosis in breast cancer. While no link has been established statistically between treatment for breast cancer and cryptorchidism in a subsequent pregnancy, this case suggests the possibility that ERβ and gene mutations may be contributing factors.PMID:33969078 | PMC:PMC8058667 | DOI:10.12998/wjcc.v9.i12.2923 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 10, 2021 Category: Cancer & Oncology Authors: Wei-Kai Hu Jing Liu Rui-Xia Liu Xiao-Wei Liu Cheng-Hong Yin Source Type: research

Perspectives on the Systemic Staging in Newly Diagnosed Breast Cancer
Clin Breast Cancer. 2021 Mar 27:S1526-8209(21)00065-3. doi: 10.1016/j.clbc.2021.03.010. Online ahead of print.ABSTRACTBreast cancer is a complex disease, and accurate systemic staging is an essential aspect of the evaluation of a patient with newly diagnosed breast cancer. Considering that the chance of having metastatic disease at breast cancer diagnosis is different in each patient and depends on a variety of anatomic and biologic factors, it is crucial to understand that some populations may benefit from more intensive staging because their pretest probability of metastatic disease is higher than that of the average pat...
Source: Clinical Genitourinary Cancer - May 8, 2021 Category: Cancer & Oncology Authors: Tom ás Reinert Alessandra Borba Anton de Souza Mahira Lopes Rosa Sabrina Richter Bedin Carlos Henrique Barrios Source Type: research

Multi-institutional survey of thymic carcinoma patients in Hokushin region
CONCLUSION: The diagnosis of thymic carcinoma is still difficult, and this disease has a tragically rapid progression if when discovered during follow-up of other diseases. An innovative modality for the early detection of thymic carcinoma is needed in modern medical society.PMID:33963906 | DOI:10.1007/s00432-021-03620-8 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 8, 2021 Category: Cancer & Oncology Authors: Hidetaka Uramoto Tomoya Takiguchi Tomonobu Koizumi Azusa Tanimoto Ryuji Hayashi Yozo Nakazawa Ken-Ichi Ito Mitsutoshi Nakada Yasuo Hirono Yoshikazu Nishino Seiji Yano Source Type: research