Ling-gui-zhu-gan decoction alleviates hepatic steatosis through SOCS2 modification by N6-methyladenosine.
CONCLUSIONS: The LGZG decoction is an effective formula for treating NAFLD, and the possible mechanisms underlying its action could be related to N6-methyladenosine modification-medicated SOCS2. PMID: 32559839 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Dang Y, Xu J, Yang Y, Li C, Zhang Q, Zhou W, Zhang L, Ji G Tags: Biomed Pharmacother Source Type: research

Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling.
Abstract Cepharanthine (CEP) is a potential candidate for treatment of cerebral ischemia/reperfusion (I/R) injury, due to its anti-inflammatory and anti-oxidative properties. To investigate the effect of CEP on cerebral I/R injury, we established a mouse model of transient middle cerebral artery occlusion (tMCAO) and a microglia cell model of oxygen and glucose deprivation/reoxygenation (OGD/R). Administration of CEP attenuated neurological deficits, reduced infarct volume and edema, and decreased microglia activation in MCAO mice. Immunofluorescence staining showed an up-regulation in NLR Family Pyrin Domain Cont...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Zhao J, Piao X, Wu Y, Liang S, Han F, Liang Q, Shao S, Zhao D Tags: Biomed Pharmacother Source Type: research

Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species level.
CONCLUSIONS: Quercetin exerts neuroprotective effect and modulates gut microbiota associated with DPN phenotypes and ROS production levels in STZ-induced DPN rats, suggesting the therapeutic application of quercetin for DPN prevention and treatment. PMID: 32559841 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Xie J, Song W, Liang X, Zhang Q, Shi Y, Liu W, Shi X Tags: Biomed Pharmacother Source Type: research

Matrine attenuates heterotopic ossification by suppressing TGF- β induced mesenchymal stromal cell migration and osteogenic differentiation.
CONCLUSIONS: Matrine inhibited HO by suppressing the migration and osteogenic differentiation of TGF-β-induced-MSCsin mice. PMID: 32559842 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Mao D, Pan X, Rui Y, Li F Tags: Biomed Pharmacother Source Type: research

A review for physiological activities of EGCG and the role in improving fertility in humans/mammals.
Abstract Epigallocatechin-3-gallate (EGCG) is a secondary metabolite in green tea, which has various physiological activities, including antioxidant, antitumor, and antiviral activities. Studies have shown that EGCG has a preventive effect on infertility by protecting germ cells and oocytes from damage. EGCG functions mainly through the regulation of ROS (reactive oxygen species) levels, which affect the expression of catalase (CAT), superoxide dismutase 1(SOD1), superoxide dismutase 2(SOD2), and glutathione peroxidase (GPx), has positive influence on other enzyme activities in germ cells and oocytes, and actively...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Zhang Y, Lin H, Liu C, Huang J, Liu Z Tags: Biomed Pharmacother Source Type: research

Combination therapy with SGLT2 inhibitors for diabetic kidney disease.
Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of oral antihyperglycemic agents developed in recent years. They could block most glucose reabsorption in renal proximal tubules, thereby exerting glucose lowering effects through glycosuric ways. The renal and cardiovascular protection effects of SGLT2 inhibitors have also been demonstrated both in preclinical studies and clinical trials. However, SGLT2 inhibitors alone could induce an increase in endogenous/hepatic glucose production as well as in fasting plasma glucose levels; a sharp decrease of blood glucose concentration induced by ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Cai Y, Liu X, Xu G Tags: Biomed Pharmacother Source Type: research

A review on ameliorative green nanotechnological approaches in diabetes management.
Abstract Diabetes mellitus is a chronic metabolic disorder which results in increase of blood glucose level mainly due to insufficient insulin secretion or body fails to respond to secreted insulin from pancreatic cells. Diabetes is mainly the third cause of death worldwide after cardiovascular diseases and cancer. Nanotechnology is an emerging area in pharmaceutical sciences as nanoparticles are reported to increase the efficacy of drugs derived from plant resources by their target specific activity. The nanomaterials synthesized from plant resources have regulatory potential in control of certain diseases with m...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Bhardwaj M, Yadav P, Dalal S, Kataria SK Tags: Biomed Pharmacother Source Type: research

The role of long non-coding RNA CASC2 in the carcinogenesis process.
Abstract The lncRNA cancer susceptibility candidate 2 (CASC2) has been initially discovered in a genomic area on 10q26 that is commonly lost in human endometrial cancer. Subsequent assessments revealed its down-regulation in almost all kinds of cancer including glioma, breast cancer, colorectal cancer, lung cancer, ovarian cancer and hepatocellular carcinoma. Yet, it has been shown to be up-regulated in astrocytoma and in paclitaxel (PTX) resistant breast cancer tissues. In vitro studies have shown the role of this lncRNA in suppression of cell proliferation and induction of apoptosis. Animal studies have shown th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Ghafouri-Fard S, Dashti S, Taheri M Tags: Biomed Pharmacother Source Type: research

Association between the microbiota and women's cancers - Cause or consequences?
We described how different phylum of bacteria, particularly in the gut, mammary tissue and vaginal microbiome may be involved in carcinogenesis; and we discuss the potential pathways involved: (I), that lead to cell proliferation, (II), immune system perturbation, (III), cell metabolic changes (e.g., hormonal factors), and (IV), DNA damage. Studies investigating the differences between the composition of the bacterial microbiota of healthy women compared to that present in various conditions, and the clinical trials are summarized for the few studies that have addressed the microbiota and related conditions, are also revie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Alizadehmohajer N, Shojaeifar S, Nedaeinia R, Esparvarinha M, Mohammadi F, Ferns GA, Ghayour-Mobarhan M, Manian M, Balouchi A Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA in cervical cancer: From biology to therapeutic opportunity.
We describe the emerging roles of lncRNAs in cervical cancer, particularly in cancer progression, metastasis, treatment resistance, HPV regulation, and metabolic reprogramming. The great promises of lncRNAs as potential biomarkers for cervical cancer diagnosis and prognosis are also discussed. We discuss current technologies used to target lncRNAs and thus control cancers, such as antisense oligonucleotides, CRISPR-Cas9, and exosomes. Overall, we show that lncRNAs hold great potentials as therapeutic agents and innovative biomarkers. Finally, further clinical research is necessary to advance our understanding of the therap...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: He J, Huang B, Zhang K, Liu M, Xu T Tags: Biomed Pharmacother Source Type: research

Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction.
CONCLUSION: GLP-1 downregulation might be an important mechanism of abnormal mitochondrial function and vascular tone in diabetes. Targeting GLP-1/CREB/adiponectin axis might become a promising therapeutic strategy in alleviating diabetes-related cardiovascular dysfunctions. PMID: 32559849 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Xiong X, Lu W, Qin X, Luo Q, Zhou W Tags: Biomed Pharmacother Source Type: research

Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.
CONCLUSION: circ-RPL15 promotes GC progression and predicts poor prognosis of GC patients, and regulates the malignant phenotypes of GC cells by mediating the miR-502-3p/OLFM4/STAT3 axis. PMID: 32559850 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Li Y, Gong Y, Ma J, Gong X Tags: Biomed Pharmacother Source Type: research

Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the "General (Jiang Jun)" in Chinese medical herb.
Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the "General (Jiang Jun)" in Chinese medical herb. Biomed Pharmacother. 2020 Jul;127:110224 Authors: Zhuang T, Gu X, Zhou N, Ding L, Yang L, Zhou M Abstract Chinese herb Rhubarb (Dahuang), one of the most widely used traditional Chinese medicine in clinical application for over a thousand years and known as the "General (Jiang Jun)" in Chinese medical herb, currently used clinically for long-term treatment of gastrointestinal diseases and chronic liver diseases. Through previous researche...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Zhuang T, Gu X, Zhou N, Ding L, Yang L, Zhou M Tags: Biomed Pharmacother Source Type: research

Non-coding RNAs are involved in the response to oxidative stress.
Abstract Oxidative stress is resulted from the imbalance between the production of oxidative agents and the antioxidant capacity. The accumulation of reactive oxygen species in this process leads to induction of several pathologic events in the tissues and organs which might affect the whole organism. This process is involved in the pathogenesis of several human disorders. Recent studies have shown the role of non-coding RNAs including both microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenic process of oxidative stress and the response of cells to this process. Thus, regulating expression of th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Ghafouri-Fard S, Shoorei H, Taheri M Tags: Biomed Pharmacother Source Type: research

DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Abstract There are limited options for targeted therapies for colorectal cancer (CRC). Anti-EGFR therapy is limited to CRC without KRAS mutations. Even worse, most of CRC are refractory to currently immune checkpoint blockade. DKK2, which is upregulated in CRC, was recently found to suppress host immune responses, and its blockage effectively impeded tumor progression in benign genetic CRC models in our previous study. Here, our recent study demonstrated that in human CRC tumor samples expressing high levels of DKK2, DKK2 blockade caused stronger activation of tumor infiltrating CD8+ T cells in ex vivo culture. In...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Hu J, Wang Z, Chen Z, Li A, Sun J, Zheng M, Wu J, Shen T, Qiao J, Li L, Li B, Wu D, Xiao Q Tags: Biomed Pharmacother Source Type: research

The IL-33/ST2 pathway suppresses murine colon cancer growth and metastasis by upregulating CD40 L signaling.
Abstract Interleukin (IL)-33 is a member of the IL-1 family, participating in both helper T1 (Th1)- and Th2-type immune responses, but its ambiguous effects on tumor growth and related immune mechanisms remain unclear. Here, we report that recombinant mouse IL-33 (mIL-33) significantly inhibited colon cancer growth and metastasis to lung and liver in a murine CT26 or MC38 tumor-cell engraftment model. This effect could be associated with CD4+ T cells and CD40 L signaling, as depletion of CD4+ T cells or blocking CD40 L signaling in vivo partly abolished the antitumor function of IL-33. In addition, IL-33 treatment...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Luo P, Deng S, Ye H, Yu X, Deng Q, Zhang Y, Jiang L, Li J, Yu Y, Han W Tags: Biomed Pharmacother Source Type: research

The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway.
This article reviews the evidence of the Nrf2 modulating hypothesis as a possible molecular mechanism underlying the medicinal properties of resveratrol. PMID: 32559855 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 22, 2020 Category: Drugs & Pharmacology Authors: Farkhondeh T, Folgado SL, Pourbagher-Shahri AM, Ashrafizadeh M, Samarghandian S Tags: Biomed Pharmacother Source Type: research

LncRNA NORAD accelerates the progression and doxorubicin resistance of neuroblastoma through up-regulating HDAC8 via sponging miR-144-3p.
In conclusion, NORAD promoted the progression and DOX resistance of NB through miR-144-3p/HDAC8 axis in vivo and in vitro. PMID: 32563146 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2020 Category: Drugs & Pharmacology Authors: Wang B, Xu L, Zhang J, Cheng X, Xu Q, Wang J, Mao F Tags: Biomed Pharmacother Source Type: research

YY1-induced lncRNA DSCR8 promotes the progression of ovarian cancer via miR-3192-5p/YY1 axis.
In this study, we aimed to search the function of DSCR8 in ovarian cancer. qRT-PCR analysis assessed the expression of DSCR8 in ovarian cancer cells. EdU assay and colony formation assay was used to test cell proliferation. Flow cytometry analysis and TUNEL assay were conducted to investigate cell apoptosis. Wound healing assay and transwell invasion assay assessed cell migration and invasion. DSCR8 was significantly up-regulated in ovarian cancer cells. Inhibited DSCR8 could suppress the progression of ovarian cancer. Also, YY1 could activate the expression of DSCR8 in ovarian cancer cells. Meanwhile, DSCR8/miR-3192-5p/YY...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2020 Category: Drugs & Pharmacology Authors: You Q, Yao Y, Wu J, Cheng C, Li Y, Yuan H Tags: Biomed Pharmacother Source Type: research

Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
In conclusion, our results reveal that CAT can induce TP's phase I detoxification enzymes CYP3A2/4 and CYP2C9 through the CAR pathway, and induce TP's phase II detoxification enzyme UGT1A6 via the NRF2 pathway when CAR is strongly inhibited. And this coordinate regulation of CAT may be an important source of the effect for CAT to increase TP metabolic conversion and reduce TP hepatotoxicity. PMID: 32563148 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2020 Category: Drugs & Pharmacology Authors: Fu L, Zhou L, Geng S, Li M, Lu W, Lu Y, Feng Z, Zhou X Tags: Biomed Pharmacother Source Type: research

Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3.
aacute;n MA, Zúñiga L Abstract Withaferin A (WFA), a C5,C6-epoxy steroidal lactone isolated from the medicinal plant Withania somnifera (L.) Dunal, inhibits growth of tumor cells in different cancer types. However, the mechanisms underlying the effect of WFA on tumor cells are not fully understood. In the present study, we evaluated the blockade of TASK-3 channels by WFA in TASK-3-expressing HEK-293 cells. Explore if the WFA-mediated TASK-3 blockade can be used as a pharmacological tool to decrease the cell viability in cancer cells. A combination of functional experiments (patch-clamp, gene downregu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2020 Category: Drugs & Pharmacology Authors: Zúñiga R, Concha G, Cayo A, Cikutović-Molina R, Arevalo B, González W, Catalán MA, Zúñiga L Tags: Biomed Pharmacother Source Type: research

A novel HDAC inhibitor chidamide combined with imatinib synergistically targets tyrosine kinase inhibitor resistant chronic myeloid leukemia cells.
In this study, we firstly demonstrated that chidamide alone inhibited CML cells proliferation, induced apoptosis and cell cycle arrest. Further, chidamide combined with imatinib (IM) induced synergistic lethality in CML cell line KBM5, as well as IM-resistant CML cells KBM5T315I, associated with a marked reduction of Bcr-Abl kinase activity and acetyl-histone H3 expression. The combination treatment markedly inhibited constitutive activity of β-catenin signaling in IM-resistant cells and abolished the protective effects of mesenchymal stromal cells (MSCs) to CML cells. In addition, the co-treatment significantly reduc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 17, 2020 Category: Drugs & Pharmacology Authors: He B, Wang Q, Liu X, Lu Z, Han J, Pan C, Carter BZ, Liu Q, Xu N, Zhou H Tags: Biomed Pharmacother Source Type: research

Corrigendum to "Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration" [Biomed. Pharmacother. 128 (2020) 110366].
Corrigendum to "Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration" [Biomed. Pharmacother. 128 (2020) 110366]. Biomed Pharmacother. 2020 Jun 16;:110394 Authors: Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L PMID: 32561180 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L Tags: Biomed Pharmacother Source Type: research

Anagliptin stimulates osteoblastic cell differentiation and mineralization.
Abstract Osteoporosis is a common debilitating bone disease characterized by loss of bone mass and degradation of the bone architecture, which is primarily driven by dysregulated differentiation of mesenchymal stem cells into bone-producing osteoblasts. Osteoblasts contribute to bone formation by secreting various proteins that guide the deposition of bone extracellular matrix, such as alkaline phosphatase (ALP), osteocalcin (OCN), and osteopontin (OPN). The Wnt/β-catenin pathway is widely recognized as a regulator of bone mass and is required to maintain bone homeostasis. Hormones have long been recognized a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Dong C, Yang H, Wang Y, Yan X, Li D, Cao Z, Ning Y, Zhang C Tags: Biomed Pharmacother Source Type: research

Mechanisms of BCG in the treatment of bladder cancer-current understanding and the prospect.
Abstract Over 30 years' successful application of Bacillus Calmette Guerin (BCG) to the clinical treatment of bladder cancer has proved it one of the most promising immunotherapies for cancer. However, the applications and achievements have failed to uncover the mechanism of BCG works on bladder cancer fully. Clinically, the administration of BCG on patients results in no effect, or apparent resistance, and even severe adverse reactions, which are inexplicable. At present, the widely confirmed and accepted immunity mechanism of BCG fall in the processes of the absorption after the instillation of BCG, the internal...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Han J, Gu X, Li Y, Wu Q Tags: Biomed Pharmacother Source Type: research

LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop.
Abstract Long noncoding RNAs (LncRNAs) are involved in multiple processes of human malignancy, and emerge as crucial molecules in RNA biology. However, the function of lncRNAs has not been well illustrated in abdominal aortic aneurysm (AAA). In this research, the effects of dysregulated ladybird homeobox 2 antisense RNA 1 (LBX2-AS1) or ladybird homeobox 2 (LBX2) on vascular smooth muscle cell (VSMC) biological processes were surveyed via cell counting kit-8 (CCK-8), methyl thiazolyl tetrazolium (MTT), terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) and caspase-3 activity assays. LBX2-AS1 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Li H, Zhang H, Wang G, Chen Z, Pan Y Tags: Biomed Pharmacother Source Type: research

Research on the mechanism of Chinese herbal medicine Radix Paeoniae Rubra in improving chronic pelvic inflammation disease by regulating PTGS2 in the arachidonic acid pathway.
Abstract Radix Paeoniae Rubra (RPR) is a traditional Chinese medicine with anti-inflammatory effects that has been used in chronic pelvic inflammation disease (CPID) therapy. However, research on the mechanism of RPR in CPID therapy is lacking. Here, we used a network pharmacology method to screen targets and found that the PTGS2 target in the arachidonic acid (AA) pathway was significantly related to CPID. Then, regarding the molecular mechanism, it was further confirmed that RPR may reduce the development of CPID by regulating the PTGS2 target. The CPID rat model was established by mixed bacterial infection. We ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Li XH, Liu YR, Jiang DH, Tang ZS, Qian DW, Song ZX, Chen L, Shi XB, Yang NJ, Yan YF, Chang AB Tags: Biomed Pharmacother Source Type: research

HCG18/miR-34a-5p/HMMR axis accelerates the progression of lung adenocarcinoma.
Abstract As the most common subtype of lung cancer, lung adenocarcinoma (LUAD) is the frequently occurred cancers in human. Therefore, thorough investigation is necessary for understanding the progression of LUAD. HMMR has functioned as a regulator in some cancers, whereas its biological role still needs to be investigated in LUAD. By bioinformatics analysis, we found that HMMR was highly expressed in LUAD tissues and associated with patients' poor prognosis. Further, qRT-PCR demonstrated that HMMR was up-regulated in LUAD tissues and cells. Loss-of-function assays manifested that HMMR knockdown refrained cell pro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Li W, Pan T, Jiang W, Zhao H Tags: Biomed Pharmacother Source Type: research

Triptolide attenuates laser-induced choroidal neovascularization via M2 macrophage in a mouse model.
CONCLUSIONS: Triptolide has therapeutic potential in CNV owing to its anti-angiogenic effect. PMID: 32559620 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Lai K, Gong Y, Zhao W, Li L, Huang C, Xu F, Zhong X, Jin C Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2.
CONCLUSIONS: Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2. PMID: 32559621 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Li K, Han H, Gu W, Cao C, Zheng P Tags: Biomed Pharmacother Source Type: research

Investigational pharmacotherapy and immunotherapy of pulmonary arterial hypertension: An update.
Abstract Pulmonary arterial hypertension (PAH) is a progressive disease with limited effective therapies that can be lethal in the terminal stage. Since the universal use of traditional PAH-specific drugs affecting the nitric oxide pathway, endothelin pathway and prostacyclin pathway, major advances to treat this devastating condition have been made. For example, it has been recently demonstrated that PAH is associated with various dysfunctional genes and molecular signaling pathways, abnormal metabolism and endocrine systems, inflammation and immune dysfunction. Numerous descriptions of novel mechanisms in PAH ha...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Yang Y, Lin F, Xiao Z, Sun B, Wei Z, Liu B, Xue L, Xiong C Tags: Biomed Pharmacother Source Type: research

Insight into potent leads for alzheimer's disease by using several artificial intelligence algorithms.
Abstract Several proteins including S-nitrosoglutathione reductase (GSNOR), complement Factor D, complement 3b (C3b) and Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK), have been demonstrated to be involved in pathogenesis pathways for Alzheimer's disease (AD) and considered as potential treatment targets to AD. Based on the concept of multitargets, a network pharmacology-based approach was employed to investigate potential Traditional Chinese Medicine (TCM) candidates that can dock well with GSNOR, C3b, Factor D and PERK proteins. To predict the bioactivities of candidates, Artificial Intelligence (AI)...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: He X, Zhao L, Zhong W, Chen HY, Shan X, Tang N, Chen CY Tags: Biomed Pharmacother Source Type: research

Qingda granules attenuate hypertensive cardiac remodeling and inflammation in spontaneously hypertensive rats.
Abstract Qingda granules (QDG) are derived from QingXuanJiangYa Decoction (QXJYD) a traditional Chinese medication that has been used to treat hypertension for more than 60 years. QXJYD has been shown to be effective in rat models of hypertension. However, the effects of QDG on hypertension remain largely unknown. In the current study, baicalin was identified as one of the main components of QDG using Ultra Performance Liquid Chromatography (UPLC) analysis. We investigated the effects of QDG on blood pressure, cardiac remodeling, and cardiac inflammation. QDG (0.8 g/kg/day) treatment attenuated the elevated...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Wu X, Shen A, Bao L, Wu M, Lin X, Wang H, Chen Y, Cai Q, Lin S, Zhou X, Lu Y, Peng M, Chen D, Chu J, Peng J Tags: Biomed Pharmacother Source Type: research

New possible pharmacological targets for statins and ezetimibe.
Abstract Statin therapy is the gold standard in the treatment of dyslipidemia. Understanding the mechanisms of action of these drugs provides an opportunity to define new therapeutic goals for pharmacotherapy in patients with atherosclerotic lesions. The present review indicates the existence of previously unknown therapeutic targets for statins, such as Krüppel-like Factor 2 (KLF-2), Cystathionine γ lyase (CSE) and the microRNA regulating eNOS activity and synthesis; nuclear PXR receptor and EB transcription factor regulating Inflammasome NLRP3 activity; the Dickkopf-related protein 1 (DKK-1), which in...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Niedzielski M, Broncel M, Gorzelak-Pabiś P, Woźniak E Tags: Biomed Pharmacother Source Type: research

Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway.
In this study, we investigate the role and mechanism of HZC in regulating HepG2 cell apoptosis and tumorigenicity, and its synergistic effects with 5-fluorouracil (5-Fu). HepG2 cells were treated with HZC and/or 5-Fu to analyze the possible synergistic effects on cell proliferation, apoptosis and cell cycle distribution in vitro using EdU staining, Hoechst staining and flow cytometry, respectively. For mechanistic investigation we used pic, a phosphatase and tensin homolog (PTEN) inhibitor, and in other studies assessed the expression pattern of PTEN and PI3K/Akt signaling pathway-related genes. Additionally, we tested in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 16, 2020 Category: Drugs & Pharmacology Authors: Zhou Y, Zhang M, Zhang Z, Jia Y, Zhang C, Peng L Tags: Biomed Pharmacother Source Type: research

Calcaneus traction compression with orthopaedic reduction forceps combined with percutaneous minimally invasive treatment of intra-articular calcaneal fractures: An analysis of efficacy.
Abstract BACKGROUND: The treatment of displaced calcaneal fractures is controversial.Open reduction and internal fixation are widely described as the gold standard in the literature,but these technique shave many complications,including skin necrosis,internal fixation leakage and deep infection and wound healing problems.Percutaneous reduction and unilateral external fixation have received increasing attention because they can provide a good, stable reduction and reduce the soft tissue complications caused by open surgery(such as deep infection and delayed wound healing).The purpose of this retrospective study was...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Jianchuan W, Song Q, Tienan W, Zongpu W, Chongjun X, Dewei Z Tags: Biomed Pharmacother Source Type: research

1,2,3,4,6 penta-O-galloyl- β-D-glucose ameliorates high-fat diet-induced nonalcoholic fatty liver disease and maintains the expression of genes involved in lipid homeostasis in mice.
In this study, we investigated the effects of PGG on a high-fat diet (HFD)-induced mouse model of NAFLD. PGG was co-administered along with an HFD to C57BL/6 mice. After eight weeks of treatment, serum biochemistry, liver steatosis, and lipid metabolism-related genes were examined. The results showed that PGG treatment significantly reduced HFD-induced gain in body weight, liver steatosis, and leukocyte infiltration in a dose-dependent manner. Furthermore, PGG treatment markedly reduced serum triglyceride and glucose levels in HFD mice. Moreover, alterations in the mRNA expression of genes involved in lipid metabolism, inc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Kant R, Lu CK, Nguyen HM, Hsiao HH, Chen CJ, Hsiao HP, Lin KJ, Fang CC, Yen CH Tags: Biomed Pharmacother Source Type: research

SOX9 enhances sorafenib resistance through upregulating ABCG2 expression in hepatocellular carcinoma.
Abstract Sorafenib is a multi-kinase blocker and one of the few suggested drug treatments for aggressive hepatocellular carcinoma (HCC) patients. However, drug resistance to sorafenib may often occur over time and cause further tumor aggression. Recently, cancer stem cells were found in HCC and were speculated to be involved in tumor progression. SOX9 is highly expressed in HCC cancer stem cells and promotes cell proliferation and self-renewal. Meanwhile, HCC patients with higher SOX9 expression show poorer prognosis. Whether SOX9 is involved in sorafenib resistance in HCC is still unclear. Here, we found that sor...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Wang M, Wang Z, Zhi X, Ding W, Xiong J, Tao T, Yang Y, Zhang H, Zi X, Zhou W, Huang G Tags: Biomed Pharmacother Source Type: research

Chemo-immunotherapy with doxorubicin prodrug and erythrocyte membrane-enveloped polymer nano-vaccine enhances antitumor activity.
Abstract There are plenty of evidences to show that combining of chemotherapy and immunotherapy should be a very potent anti-cancer therapeutic method. In this research, we evaluated the anti-tumor activity of doxorubicin prodrug combined with erythrocyte membrane-enveloped polymer nano-vaccine against tumor in vitro and in vivo. We also analyzed the immune cell populations to investigate the effect in the tumor microenvironment and explored the inhibitory of lung metastasis. Our study showed that chemo-immunotherapy could inhibit the growth of melanoma tumor in mice. This combination approach promoted a stronger ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Bao Y, Hu Q, Wang X, Feng X, He Y, Guo Y, Fu D Tags: Biomed Pharmacother Source Type: research

Colchicine prevents atrial fibrillation promotion by inhibiting IL-1 β-induced IL-6 release and atrial fibrosis in the rat sterile pericarditis model.
Colchicine prevents atrial fibrillation promotion by inhibiting IL-1β-induced IL-6 release and atrial fibrosis in the rat sterile pericarditis model. Biomed Pharmacother. 2020 Jun 15;129:110384 Authors: Wu Q, Liu H, Liao J, Zhao N, Tse G, Han B, Chen L, Huang Z, Du Y Abstract A few clinical trials have recently reported the potential effect of colchicine in preventing post-operative atrial fibrillation (POAF) and early atrial fibrillation (AF) recurrence after catheter pulmonary vein isolation. However, the molecular mechanisms through which colchicine inhibits AF remain unclear. We aim to assess...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Wu Q, Liu H, Liao J, Zhao N, Tse G, Han B, Chen L, Huang Z, Du Y Tags: Biomed Pharmacother Source Type: research

The extract of Trachelospermum jasminoides (Lindl.) Lem. vines inhibits osteoclast differentiation through the NF- κB, MAPK and AKT signaling pathways.
The extract of Trachelospermum jasminoides (Lindl.) Lem. vines inhibits osteoclast differentiation through the NF-κB, MAPK and AKT signaling pathways. Biomed Pharmacother. 2020 Jun 15;129:110341 Authors: Jiang T, Yan W, Kong B, Wu C, Yang K, Wang T, Yan X, Guo L, Huang P, Jiang M, Xi X, Xu X Abstract Osteoclasts are the only cells in the body with a bone-resorption function. The identification of anti-osteoclastogenic agents is important in managing bone loss diseases. The dried vines of Trachelospermum jasminoides (Lindl.) Lem. have been used as a herbal medicine to treat musculoskeletal sorene...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Jiang T, Yan W, Kong B, Wu C, Yang K, Wang T, Yan X, Guo L, Huang P, Jiang M, Xi X, Xu X Tags: Biomed Pharmacother Source Type: research

Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF- β/CCL9 pathway.
Chinese herbal medicine Baoyuan Jiedu decoction inhibits the accumulation of myeloid derived suppressor cells in pre-metastatic niche of lung via TGF-β/CCL9 pathway. Biomed Pharmacother. 2020 Jun 15;129:110380 Authors: Tian S, Song X, Wang Y, Wang X, Mou Y, Chen Q, Zhao H, Ma K, Wu Z, Yu H, Han X, Wang H, Wang S, Ji X, Zhang Y Abstract Baoyuan Jiedu (BYJD for short) decoction, a traditional Chinese medicine formula, is composed of Astragalus, Ginseng, Aconite root, Honeysuckle, Angelica, Licorice, which has the functions of nourishing qi and blood, enhancing immune function, improving quality of ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Tian S, Song X, Wang Y, Wang X, Mou Y, Chen Q, Zhao H, Ma K, Wu Z, Yu H, Han X, Wang H, Wang S, Ji X, Zhang Y Tags: Biomed Pharmacother Source Type: research

Effects of diosgenin on the skeletal system in rats with experimental type 1 diabetes.
Abstract There is a great interest in substances of plant origin, which may exert health-promoting activities in diabetes and its complications. Previous studies suggested that diosgenin may favorably affect both glucose metabolism and osteoporosis. The aim of the study was to investigate the effects of diosgenin on the skeletal disorders induced by experimental type 1 diabetes (T1D) in rats. The experiments were performed on 3-month-old female rats, divided into three groups: I - healthy control rats, II - streptozotocin-induced diabetic control rats, III - diabetic rats receiving diosgenin. T1D was induced by a ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Londzin P, Kisiel-Nawrot E, Kocik S, Janas A, Trawczyński M, Cegieła U, Folwarczna J Tags: Biomed Pharmacother Source Type: research

The anti-inflammatory and immune-modulatory effects of OEA limit DSS-induced colitis in mice.
CONCLUSIONS AND IMPLICATIONS: These results underscore the validity of OEA as a potent protective and anti-inflammatory agent in ulcerative colitis that may be exploited to broaden the pharmacological strategies against inflammatory bowel disease. PMID: 32559625 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 15, 2020 Category: Drugs & Pharmacology Authors: Lama A, Provensi G, Amoriello R, Pirozzi C, Rani B, Mollica MP, Raso GM, Ballerini C, Meli R, Passani MB Tags: Biomed Pharmacother Source Type: research

SNHG11 contributes to NSCLC cell growth and migration by targeting miR-485-5p/BSG axis.
Abstract Accumulating studies implied that long noncoding RNAs (lncRNAs) act as essential factors in regulating diverse biological behaviors of cancers. Small nucleolar RNA host gene 11 (SNHG11) has been reported as for its oncogenic properties in several cancer types. However, it is unclear whether SNHG11 exerts functions in non-small cell lung cancer (NSCLC) remains unclear. The aim of this study was to inspect the role and regulatory mechanism of SNHG11 in NSCLC. The expression of SNHG11 in NSCLC cells was analyzed by qRT-PCR. Functional experiments were carried out to determine the effects of SNHG11 silence on...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 13, 2020 Category: Drugs & Pharmacology Authors: Cheng R, Lu X, Xu C, Zhang F, Zhang G Tags: Biomed Pharmacother Source Type: research

PDB-1 from Potentilla discolor Bunge induces apoptosis and autophagy by downregulating the PI3K/Akt/mTOR signaling pathway in A549 cells.
This study focused on clarifying PDB-1's anticancer mechanism in the inhibition of proliferation and in the induction of apoptosis and autophagy in A549 cells. In general, A549 cells were treated with PDB-1 for different times, and cell survival was assessed by a CCK8 assay. The assessment of intracellular reactive oxygen species, a mitochondrial membrane potential assay, a cell cycle assay, an annexin V-FITC/PI assay, and MDC staining were performed in A549 cells treated with PDB-1. Moreover, the mRNA and protein expression of cell cycle-, apoptosis- and autophagy-related factors were detected by RT-qPCR and western blott...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 13, 2020 Category: Drugs & Pharmacology Authors: Zhang RR, Meng NN, Liu C, Li KL, Wang MX, Lv ZB, Chen SY, Guo X, Wang XK, Wang Q, Sun JY Tags: Biomed Pharmacother Source Type: research

Combined chemotherapy with cyclooxygenase-2 (COX-2) inhibitors in treating human cancers: Recent advancement.
Abstract Chemotherapy with a single chemotherapeutic agent or a combined chemotherapeutic regimen is the clinically standardized treatment for almost all human cancers. Upregulated expression of cyclooxygenase (COX)-2, also known as prostaglandin-endoperoxide synthase (PTGS), is associated with human carcinogenesis and cancer progression and COX-2 inhibitors show antitumor activity in different human cancers. Thus, a combination of chemotherapeutic agents with COX-2 inhibitors has been shown to improve therapeutic effects on human cancers. This review discusses and summarizes recent advances in cancer control and ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2020 Category: Drugs & Pharmacology Authors: Li S, Jiang M, Wang L, Yu S Tags: Biomed Pharmacother Source Type: research

Current potential therapeutic strategies targeting the TGF- β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.
Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 2020 Jun 12;129:110287 Authors: Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ Abstract Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process with chronic inflammation. The TGF-β/Smad signaling pathway is the most canonical pathway through which the formation of collagen in the fibroblasts and myofibroblasts is regul...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2020 Category: Drugs & Pharmacology Authors: Zhang T, Wang XF, Wang ZC, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH, Tan WQ Tags: Biomed Pharmacother Source Type: research

The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases.
Abstract ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins. ALOX12 protein plays an important role in inflammation and oxidation, while abnormal DNA methylation and genetic variants of ALOX12 are associated with various human diseases and pathological phenotypes, such as cardiovascular disease, diabetes, neurodegenerative diseases, respiratory system disease, cancer, infection, etc. Here, this article reviews the mechanisms by which ALOX12 participates in related diseases, whic...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2020 Category: Drugs & Pharmacology Authors: Zheng Z, Li Y, Jin G, Huang T, Zou M, Duan S Tags: Biomed Pharmacother Source Type: research

Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy.
Abstract Endoplasmic reticulum stress (ERS), mutual crosstalk between autophagy and apoptosis-related signaling pathway, plays an important role in the process of acute liver injury (ALI). The present study was to investigate the effects and underlying mechanisms of Asiatic acid from Potentilla chinensis (AAPC) on ALI. The model of ALI in mice was induced by administration with Lipopolysaccharide/D-Galactosamine (LPS/D-GalN). The effects of AAPC on hepatic pathology and hepatocyte apoptosis were observed by hematoxylin-eosin (H&E) staining and TUNEL staining. Serum transaminases activities were measured using ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 12, 2020 Category: Drugs & Pharmacology Authors: Pang X, Qiao Q, Vonglorkham S, Feng Z, Pang L, Chen S, Wang D, Lao L, Lin X, Wei J Tags: Biomed Pharmacother Source Type: research