Therapeutic effects of JLX001 on cerebral ischemia through inhibiting platelet activation and thrombus formation in rats.
This study aims to confirm the therapeutic effect of JLX001 on cerebral ischemia and researchits antiplatelet and antithrombosis activities via thromboxane (TXA2)/phospholipase C-β-3(PLCβ3)/protein kinase C (PKC) pathway suppression. The therapeutic effects of JLX001 was evaluated by infarct sizes, brain edema and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Brain TXA2 and prostacyclin (PGI2) were measured by enzyme-linked immunosorbentassay (ELISA). P-PLCβ3and activated PKC were detected by immunohistochemical method. Adenosine diphosphate (ADP) or 9, 11-dieo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2018 Category: Drugs & Pharmacology Authors: Yan YY, Ao LY, Zhou L, Li CY, Fang WR, Shen WY, Liang BW, Zhu X, Li YM Tags: Biomed Pharmacother Source Type: research

Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis.
Abstract OBJECTIVE: To discuss the curative effect and security of triptolide (TPL) on TNF transgenic (TNF-Tg) mice with rheumatoid arthritis (RA), and to explore the mechanism primarily. METHOD: 40 TNF-Tg RA mice were randomlydivided into five groups averagely: the control group, low-dose group (3.3 μg/kg/d TPL), middle-dose group (10 μg/kg/d TPL), high-dose group (33 μg/kg/d TPL) and MTX group (0.1 mg/kg/d MTX). Mice were administrated five days a week for six weeks. The arthritis deformation index, arthritis detumescencepercentage and the level of inflammatory factor in each group were rec...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2018 Category: Drugs & Pharmacology Authors: Wang S, Zuo S, Liu Z, Ji X, Yao Z, Wang X Tags: Biomed Pharmacother Source Type: research

β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells.
β-Asarone suppresses Wnt/β-catenin signaling to reduce viability, inhibit migration/invasion/adhesion and induce mitochondria-related apoptosis in lung cancer cells. Biomed Pharmacother. 2018 Jul 07;106:821-830 Authors: Wang TL, Ouyang CS, Lin LZ Abstract Lung cancer is the leading cause of cancer death worldwide. Chemotherapy is one of the most effective strategies for lung cancer treatment. However, the side effects of chemotherapy limit the application of chemotherapeutic agents. The β-Asarone, a low-toxicity natural compound from a traditional Chinese medicinal herb, has been demons...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 7, 2018 Category: Drugs & Pharmacology Authors: Wang TL, Ouyang CS, Lin LZ Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA LINC00222 regulates GSK3 β activity and promotes cell apoptosis in lung adenocarcinoma.
Long non-coding RNA LINC00222 regulates GSK3β activity and promotes cell apoptosis in lung adenocarcinoma. Biomed Pharmacother. 2018 Jul 06;106:755-762 Authors: Zhang H, Wang Y, Lu J, Zhao Y Abstract Recent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulating cellular processes such as differentiation, proliferation, metastasis and apoptosis. These lncRNAs are found to be dysregulated in a variety of cancers. However, the underlying mechanisms of lncRNAs action in lung adenocarcinoma remain unclear. We investigated expression of the lncRNA LINC00222 in 76 l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Zhang H, Wang Y, Lu J, Zhao Y Tags: Biomed Pharmacother Source Type: research

MiR-185 enhances radiosensitivity of colorectal cancer cells by targeting IGF1R and IGF2.
CONCLUSION: In summary, our study is the first to show that upregulation of miR-185 enhances the sensitivity of CRC cells to ionizing radiation. miR-185 may act as a novel biomarker of radioresistance and may clinically enhance the radiation response of CRC. PMID: 29990869 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Afshar S, Najafi R, Sedighi Pashaki A, Sharifi M, Nikzad S, Gholami MH, Khoshghadam A, Amini R, Karimi J, Saidijam M Tags: Biomed Pharmacother Source Type: research

Naringenin inhibits prostate cancer metastasis by blocking voltage-gated sodium channels.
In conclusion, naringenin was found to have direct or indirect blocking activity on voltage-gated sodium channels encoded by the SCN9A gene. PMID: 29990870 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Gumushan Aktas H, Akgun T Tags: Biomed Pharmacother Source Type: research

Role of TLR4/MyD88/NF- κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.
This study investigated the myocardial protective effects of nicorandil pretreatment on CME-induced myocardial injury and the specific mechanism of its inhibition of myocardial inflammation. An CME rat model exhibited CME-induced myocardial inflammation and the elevation of serum tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-1β based on echocardiography, myocardial enzyme detection, hematoxylin and eosin (HE) and hematoxylin-basic fuchsin-picric acid (HBFP) stainings, ELISA, quantitative real-time PCR, and western blotting. Nicorandil treatment seven days before CME induction effectively inhibited myo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Su Q, Lv X, Sun Y, Ye Z, Kong B, Qin Z Tags: Biomed Pharmacother Source Type: research

Plumbagin ameliorates hepatic ischemia-reperfusion injury in rats: Role of high mobility group box 1 in inflammation, oxidative stress and apoptosis.
Abstract Ischemia-reperfusion (I/R) injury is a pathological process which magnifies with the ensuing inflammatory response and endures with the increase of oxidants especially during reperfusion. The present study was conducted to assess the possible modulatory effects of plumbagin, the active constituent extracted from the roots of traditional medicinal plant Plumbago zeylanica L., on the dire role of high mobility group box 1 (HMGB1) as well as the associated inflammation, oxidative stress and apoptotic cell death following hepatic I/R. Four groups of rats were included: sham-operated, sham-operated treated wit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Zaki AM, El-Tanbouly DM, Abdelsalam RM, Zaki HF Tags: Biomed Pharmacother Source Type: research

A novel synthesized 3', 5'-diprenylated chalcone mediates the proliferation of human leukemia cells by regulating apoptosis and autophagy pathways.
In this study, we investigated the molecular mechanisms of the anti-leukemia effects of C10 on different leukemia cells in vitro. C10 showed strong inhibition of proliferation of the human erythroleukemia cell line HEL and human myeloid leukemia cell line K562, and several cell and flow cytometer assays showed that inhibition by C10 was due to the regulation of gene expression or phosphorylation in the apoptosis and autophagy pathways. The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 6, 2018 Category: Drugs & Pharmacology Authors: Zhang YQ, Wen ZH, Wan K, Yuan D, Zeng X, Liang G, Zhu J, Xu B, Luo H Tags: Biomed Pharmacother Source Type: research

Non-toxic and non teratogenic extract of Thuja orientalis L. inhibited angiogenesis in zebra fish and suppressed the growth of human lung cancer cell line.
Abstract Lung cancer is a malignant tumour with minimal survival rate and the current treatments are not showing complete remission of tumour and have many side effects. Thus a natural herbal medicine with good anti-cancer properties is highly demanded. Thuja orientalis L. is a traditionally used medicine to cure cough, bronchitis, excessive menstruation, asthma, skin infection and premature baldness. In addition, recent studies have revealed that it has anti-proliferative and anti-cancer activity. Angiogenesis is the main reason for the propagation and metastasis of cancers. We therefore intended to study the eff...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: R EB, Jesubatham PD, V M BG, S V, S S Tags: Biomed Pharmacother Source Type: research

Emerging landscape in psoriasis management: From topical application to targeting biomolecules.
Abstract Psoriasis is a chronic autoimmune skin disorder affecting 2-3% of the world population. It has characteristic features such as increased keratinocyte proliferation and production of inflammatory mediators. The treatment involves various strategies including topical, systemic, phototherapy and biologics. Topical therapies are preferred for mild to moderate psoriasis conditions over the systemic therapies which are ideal in severe disease conditions. The systemic therapies include immunosuppressants, biological agents and recently approved phosphodiesterase-4 (PDE4) inhibitors. There are various limitations...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: Rapalli VK, Singhvi G, Dubey SK, Gupta G, Chellappan DK, Dua K Tags: Biomed Pharmacother Source Type: research

Role of oxidative stress in pathology of chronic prostatitis/chronic pelvic pain syndrome and male infertility and antioxidants function in ameliorating oxidative stress.
Abstract Oxidative stress (OS) is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body that can cause tissue damage. Oxidative stress has a significant involvement in the pathogenesis of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and male infertility. CP/CPPS is a major risk factor for male infertility due to generation of excessive ROS that damage sperm DNA, lipids, and proteins, resulting in compromised vitality and decreased sperm motility. Here we present a comprehensive review of oxidative stress relevance in CP/CPPS and male infertility, and embody the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: Ihsan AU, Khan FU, Khongorzul P, Ahmad KA, Naveed M, Yasmeen S, Cao Y, Taleb A, Maiti R, Akhter F, Liao X, Li X, Cheng Y, Khan HU, Alam K, Zhou X Tags: Biomed Pharmacother Source Type: research

Immunomodulatory effect of Arabinosylated lipoarabinomannan restrict the progression of visceral leishmaniasis through NOD2 inflammatory pathway: Functional regulation of T cell subsets.
Abstract NOD like receptors (NLR) are essential pathogen associated molecular pattern receptors of cytoplasmic origin. During several intracellular parasitic infections NLR played vital role for host protective immune response against the pathogen. Amongst various classes of NLR, NOD1 and NOD2 had been extensively studied and were found to be the most active member of the NLR family. Therefore, we wanted to study the role of NOD1/NOD2 during Leishmania donovani infection and the mechanism behind the utilization of this pathway as a therapeutic approach. Using the infected model of macrophage and BALB/c mice the ex...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: Jawed JJ, Banerjee S, Bandyopadhyay S, Parveen S, Chowdhury BP, Saini P, Majumdar S Tags: Biomed Pharmacother Source Type: research

Tangganjian decoction ameliorates type 2 diabetes mellitus and nonalcoholic fatty liver disease in rats by activating the IRS/PI3K/AKT signaling pathway.
CONCLUSION: A high concentration of TGJ can improve glucose and lipid metabolism by activating the IRS/PI3K/AKT signaling pathway. PMID: 29990865 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: Fan Y, He Z, Wang W, Li J, Hu A, Li L, Yan L, Li Z, Yin Q Tags: Biomed Pharmacother Source Type: research

Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis.
CONCLUSION: MALAT1 knockdown attenuated myocardial apoptosis through suppressing Pten expression by sponging miR-320 in mouse AMI. PMID: 29990866 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: Hu H, Wu J, Li D, Zhou J, Yu H, Ma L Tags: Biomed Pharmacother Source Type: research

Role of PI3K/Akt/NF- κB and GSK-3β pathways in the rat model of cardiopulmonary bypass-related lung injury.
Role of PI3K/Akt/NF-κB and GSK-3β pathways in the rat model of cardiopulmonary bypass-related lung injury. Biomed Pharmacother. 2018 Jul 05;106:747-754 Authors: He M, Zhang Y, Xie F, Dou X, Han M, Zhang H Abstract BACKGROUND: Apoptosis is a cellular mechanism contributing to cardiac surgery using cardiopulmonary bypass (CPB)-induced lung injury. The ubiquitous PI3K/Akt pathway regulates proliferation, apoptosis and differentiation by controlling a broad range of target proteins including NF-κB and GSK-3β. The roles of the PI3K/Akt/NF-κB and PI3K/Akt/GSK-3β pathways in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: He M, Zhang Y, Xie F, Dou X, Han M, Zhang H Tags: Biomed Pharmacother Source Type: research

Increased lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line LoVo and its doxorubicin-resistant subline LoVo/Dx in the presence of newly synthesized phenothiazine derivatives.
Abstract Cancer cells often develop the resistance to pro-apoptotic signaling that makes them invulnerable to conventional treatment. Therapeutic strategies that make cancer cells enter the path of apoptosis are desirable due to the avoidance of inflammatory reaction that usually accompanies necrosis. In the present study phenothiazines (fluphenazine and four recently synthesized derivatives) were investigated in order to identify compounds with a potent anticancer activity. Since phenothiazines are known as multidrug resistance modulators the sensitive human colorectal adenocarcinoma cell line (LoVo) and its doxo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Środa-Pomianek K, Michalak K, Świątek P, Poła A, Palko-Łabuz A, Wesołowska O Tags: Biomed Pharmacother Source Type: research

Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freund's adjuvant induced arthritis with reduced hepatotoxicity.
CONCLUSIONS: A combined therapy of AD and methotrexate significantly alleviated MTX-induced hepatocellular injury and strengthened the anti-arthritic effect. Further clinical studies should be done to further verify the possibility of combined its clinical usage. PMID: 29990853 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Li F, Li H, Luo S, Ran Y, Xie X, Wang Y, Zheng M, Wang M, Zhao Z, Li X Tags: Biomed Pharmacother Source Type: research

Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling.
In this study, we modelled the OSCC invasion front on a microfluidic chip, and investigated differences in miRNA profiles between cells in the invasion front and those in the tumor mass by small RNA sequencing. We found that miR-218-5p was downregulated in invasion front cells and negatively regulates OSCC invasiveness by targeting the CD44-ROCK pathway. Thus, miR-218-5p may serve as a useful therapeutic target for OSCC. Moreover, invasion front cell isolation based-on microfluidic technology provided a useful strategy for cancer invasion study. PMID: 29990854 [PubMed - as supplied by publisher] (Source: Biomedicine a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Li X, He J, Shao M, Cui B, Peng F, Li J, Ran Y, Jin D, Kong J, Chang J, Duan L, Yang X, Luo Y, Lu Y, Lin B, Liu T Tags: Biomed Pharmacother Source Type: research

β-asarone induces cell apoptosis, inhibits cell proliferation and decreases migration and invasion of glioma cells.
In this study, human glioma U251 cells and rat glioma C6 cells were treated with different concentrations of β-asarone. Cultured them for 24 h, 48 h, 72 h and evaluated the IC50 with the results of Counting Kit-8 assay. Then, cell apoptosis and cell DNA cycles were evaluated with flow cytometry. Apoptosis related mRNA and protein were analyzed In addition, cell migration and invasion were also detected with wound healing and transwell assays, respectively. What is more, glioma specific proteins: GFAP, NRP-1 and NSE an enzyme-linked immunosorbent assay. The corresponding CCK-8 results showed that β-asarone a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Wang N, Han Y, Luo L, Zhang Q, Ning B, Fang Y Tags: Biomed Pharmacother Source Type: research

MicroRNA-1469, a p53-responsive microRNA promotes Genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells.
In this study, we report that miR-1469 was induced by genistein in laryngeal cancer. Elevated miR-1469 promoted cell apoptosis and inhibited Mcl1 expression. In addition, we also observed that tumor suppressor p53 was increased under genistein treatment. Elevation of p53 promoted miR-1469 expression, leading to miR-1469 increase and Mcl1 decrease. Therefore, our findings suggest that genistein can suppress laryngeal cancer cell survival through p53 -miR-1469-Mcl1pathway. PMID: 29990856 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Ma CH, Zhang YX, Tang LH, Yang XJ, Cui WM, Han CC, Ji WY Tags: Biomed Pharmacother Source Type: research

KLF15 suppresses cell growth and predicts prognosis in lung adenocarcinoma.
Abstract Krüppel-like factors (KLFs) are transcription factors containing three different C2H2-type zinc finger domains in their carboxy-terminal regions which have been identified to play important roles in a variety of cancers. However, little is known about KLF15 in lung adenocarcinoma (LAUD). Our study demonstrated that the expression levels of KLF15 were observably down-regulated in LAUD tissues compared to paired adjacent normal tissues. LUAD patients with low expression levels of KLF15 have worse prognosis than those with high expression levels of KLF15. KLF15 could suppress cell growth, which was part...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Wang X, He M, Li J, Wang H, Huang J Tags: Biomed Pharmacother Source Type: research

Repression of Dok7 expression mediated by DNMT1 promotes glioma cells proliferation.
In this study, we illustrated that the expression of Dok7 was downregulation in human glioma tissues. Dok7 overexpression significantly inhibits proliferation and colony formation in vitro, and the xenograft tumor formation in vivo. In addition, 5-Aza-2'-deoxycytidine (5-Aza), a DNA methylation inhibitor, preventing the loss of Dok7 expression by decreasing aberrant hypermethylation of Dok7 promoter in glioma cells. More importantly, DNMT1 knockdown induced the demethylation of Dok7 promoter, and enhanced the expression of Dok7 in gliomas. These results suggest that epigenetic silencing of Dok7 may provide a novel glioma t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Hua CD, Bian EB, Chen EF, Yang ZH, Tang F, Wang HL, Zhao B Tags: Biomed Pharmacother Source Type: research

Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPAR γ activation in human umbilical vein endothelial cells.
Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARγ activation in human umbilical vein endothelial cells. Biomed Pharmacother. 2018 Jul 04;106:686-691 Authors: Tsukahara T, Yamagishi S, Matsuda Y, Haniu H Abstract We previously showed that an alkyl-ether analog of lysophosphatidic acid, AGP (alkyl-glycerophosphate), accumulates in human atherosclerotic plaques and is a potent agonist of peroxisome proliferator-activated receptor-gamma (PPARγ). On the other hand, cyclic phosphatidic acid (cPA), similar in structure to AGP, can negativ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Tsukahara T, Yamagishi S, Matsuda Y, Haniu H Tags: Biomed Pharmacother Source Type: research

Sulfur dioxide attenuates hypoxia-induced pulmonary arteriolar remodeling via Dkk1/Wnt signaling pathway.
CONCLUSION: Together, these findings indicate that SO2 could attenuate hypoxia-induced pulmonary arteriolar remodeling and may suppress the proliferation and migration of PASMCs at least in part through the Dkk1/Wnt signaling pathway. PMID: 29990860 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 4, 2018 Category: Drugs & Pharmacology Authors: Luo L, Hong X, Diao B, Chen S, Hei M Tags: Biomed Pharmacother Source Type: research

Wogonoside induces apoptosis in human non-small cell lung cancer A549 cells by promoting mitochondria dysfunction.
Abstract Non-small cell lung cancer (NSCLC) is one of the most prevailing malignancies worldwide. It has been previously shown that wogonoside exerts anti-tumor activities in various kinds of human cancers. But its role in NSCLC remains elusive. In the present study, we determined the anti-tumor effect of wogonoside in human NSCLC A549 cells. We found that wogonoside effectively inhibits A549 cell viability through inducing cell cycle arrest and apoptosis. Moreover, administration of wogonoside by intraperitoneal injection inhibits the growth of A549 cell xenografts in athymic nude mice. Additionally, mitochondria...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 3, 2018 Category: Drugs & Pharmacology Authors: Luo M, Mo J, Yu Q, Zhou S, Ning R, Zhang Y, Su C, Wang H, Cui J Tags: Biomed Pharmacother Source Type: research

Gamma irradiation of Toxoplasma gondii protein extract improve immune response and protection in mice models.
Abstract Gamma radiation induces protein changes that enhance immunogenicity for venoms, used in antivenin production. Coccidian parasites exposed to gamma radiation elicit immune response with protection in mice and man, but without studies on the effect of gamma radiation in soluble acellular extracts or isolated proteins. Toxoplasmosis is a highly prevalent coccidian disease with only one vaccine for veterinary use but with remaining tissue cysts. Total parasite extracts or recombinant proteins used as immunogen induce usually low protection. Here, we study gamma radiation effect on T. gondii extracts proteins ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 3, 2018 Category: Drugs & Pharmacology Authors: da Costa A, Zorgi NE, do Nascimento N, Galisteo AJ, de Andrade HF Tags: Biomed Pharmacother Source Type: research

Plasma concentrations of the trace elements copper, zinc and selenium in Brazilian children with autism spectrum disorder.
In this study, we investigated 23 pediatric subjects (≤ 18 yrs old, both sexes) with ASD, all residents in the city of Campo Grande in Brazil, by searching for their micronutrient levels in plasma in relation with metabolic and nutrition biomarkers. Aside for the few evidence reported, generally, the Brazilian cohort of ASD children here examined did not show a marked difference in micro-nutrient intake in relation with their resident geographical area and their dietary habit or metabolic state, although a slight difference in the levels of magnesium and phosphorus was retrieved due to sex difference. PMID: 2999084...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 3, 2018 Category: Drugs & Pharmacology Authors: Saldanha Tschinkel PF, Bjørklund G, Conón LZZ, Chirumbolo S, Nascimento VA Tags: Biomed Pharmacother Source Type: research

Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures.
Abstract Radiation countermeasures are radioprotective agents that reduce the harmful effects of ionizing radiation. They have wide range of applications extending from protection of normal tissues of cancer patients during radiotherapy to safeguard people aftermath of radiologic or nuclear accidents. Despite the screening of thousands of natural and synthetic compounds, only few found place in clinic with limited tolerance. Therefore, mechanistic understanding is essential in the development of more suitable and customized radiation countermeasure agents. This review focuses on the mechanisms of radioprotection i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 3, 2018 Category: Drugs & Pharmacology Authors: Mishra KN, Moftah BA, Alsbeih GA Tags: Biomed Pharmacother Source Type: research

Characterization of cardiovascular depression effect for propofol during anesthesia induction period on morbidly obese patients.
This study aims to determine the pharmacodynamics (PD) effect (measured by cardiovascular depression) of propofol during anesthesia induction period on morbidly obese (MO) patients. Four hemodynamics indexes [i.e., three indexes about blood pressure and cardiac output (CO)] representing cardiovascular function were measured. Pharmacokinetic/pharmacodynamic (PK/PD) modeling was performed by population analysis to obtain PD parameters. Two propofol dosing scalars, namely, dosing based on total body weight (TBW) or lean body weight (LBW), were used for MO subjects. The PD data were well described by a PK/PD model. Blood press...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 3, 2018 Category: Drugs & Pharmacology Authors: Wu Z, Li J, Wang C, Yang J, Chen X, Yang W, Xiong Z, Peng X Tags: Biomed Pharmacother Source Type: research

Research on the pharmacodynamics and mechanism of Fraxini Cortex on hyperuricemia based on the regulation of URAT1 and GLUT9.
In this study, different sources of QP were collected from Shaanxi Qinpi extracts (SQPE), Henan Qinpi extracts (HQPE), Hebei Qinpi extracts (GQPE) provinces in China. Rat model of hyperuricemia with hypoxanthine combined with potassium oxonate were established to determine the levels of blood urea nitrogen (BUN), serum uric acid (SUA), urine uric acid (UUA) and creatinine (Cr). Hematoxylin-eosin staining (H&E) and Periodic Acid-Schiff staining (PAS) were performed for renal pathology while Western blot analysis and real-time PCR analysis for proteins and mRNA expression levels. High-performance liquid chromatograph (HP...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Zhou Y, Zhang X, Li C, Yuan X, Han L, Li Z, Tan X, Song J, Wang G, Jia X, Feng L, Qiao X, Liu J Tags: Biomed Pharmacother Source Type: research

Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis.
In this study, protective effects of morin against DOX-induced cardiotoxicity and neurotoxicity in rats were investigated. Morin was orally administered to rats at a dose of 50 and 100 mg/kg body weight for 10 days. DOX was administered 40 mg/kg body weight by single dose intraperitoneal injection on the 8th day of the study. Both the levels of glutathione (GSH) and malondialdehyde (MDA) were assessed and enzyme activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were assessed to determine the protective effect of morin against oxidative stress. To determine the anti-inflammatory e...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Kuzu M, Kandemir FM, Yildirim S, Kucukler S, Caglayan C, Turk E Tags: Biomed Pharmacother Source Type: research

An ellagic acid isolated from Clerodendrum viscosum leaves ameliorates iron-overload induced hepatotoxicity in Swiss albino mice through inhibition of oxidative stress and the apoptotic pathway.
Abstract Iron is a vital element required for normal cellular physiology in animal systems, but excess iron accumulation in the biological system accelerates oxidative stress, cellular toxicity, tissue injury and organ fibrosis, which ultimately leads to the generation of chronic liver diseases including cancer. A natural antioxidant, ellagic acid (EA) has been previously reported for its pharmacological properties; however, there is no significant evidence available that could illustrate its protective potential against iron-overload induced hepatotoxicity. In the present work, EA was evaluated for its in vitro f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Shendge AK, Basu T, Panja S, Chaudhuri D, Mandal N Tags: Biomed Pharmacother Source Type: research

Dexmedetomidine protects high-glucose induced apoptosis in human retinal pigment epithelial cells through inhibition on p75(NTR).
CONCLUSION: DEX was proven to have protective effect on DG-induced RPE apoptosis, possible through inhibition on p75(NTR) and its associated signaling pathways. PMID: 29990834 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Liu R, Li X, Zhang X Tags: Biomed Pharmacother Source Type: research

Expression kinetics reveal the self-adaptive role of β cells during the progression of diabetes.
CONCLUSIONS: The β-cells follow a biphasic pattern of expression of certain factors in order to achieve a balance between apoptosis, autophagy, neo-genesis, hypoxia and proliferation, and achieve homeostatic protection before the onset of diabetes. The drug interventions at an early stage, which are specific to these pathways, could be beneficial in preventing the progression of diabetes pathogenesis. PMID: 29990835 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Srivastava S, Pandey H, Tripathi YB Tags: Biomed Pharmacother Source Type: research

MicroRNA-298 represses hepatocellular carcinoma progression by inhibiting CTNND1-mediated Wnt/ β-catenin signaling.
In conclusion, our findings provide the first evidence that miR-298 suppresses HCC progression at least partially by targeting CTNND1-mediated Wnt/β-catenin signaling. MiR-298 may be a target for new therapies in HCC patients. PMID: 29990836 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Cao N, Mu L, Yang W, Liu L, Liang L, Zhang H Tags: Biomed Pharmacother Source Type: research

Vascular endothelial growth factor over-expressed mesenchymal stem cells-conditioned media ameliorate palmitate-induced diabetic endothelial dysfunction through PI-3K/AKT/m-TOR/eNOS and p38/MAPK signaling pathway.
In this study, we tested whether MSCs over-expressing VEGF conditioned medium (MSC-VEGF-CM) could ameliorate pancreatic islet endothelial cells (MS-1) dysfunction induced by a common diabetic inducer palmitate (PA). We found that cell survival and migration were restrained by PA and partly repaired by the pro-protected of MSC-VEGF-CM. Meanwhile, PI-3K/AKT/m-TOR/eNOS and p38/MAPK signaling pathways were also up-regulated. Though apoptosis-related proteins, caspase-3 and caspase-9, had no significantly suppressed between MSC-VEGF-CM and MSC-CM alone, the expression levels of vascular surface factors such as CD31, VE-cadherin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Xu T, Lv Z, Chen Q, Guo M, Wang X, Huang F Tags: Biomed Pharmacother Source Type: research

Commiphora molmol protects against methotrexate-induced nephrotoxicity by up-regulating Nrf2/ARE/HO-1 signaling.
In conclusion, C. molmol resin provided protection against MTX-induced AKI via activation of Nrf2 signaling and mitigation of oxidative stress. PMID: 29990838 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Mahmoud AM, Germoush MO, Al-Anazi KM, Mahmoud AH, Farah MA, Allam AA Tags: Biomed Pharmacother Source Type: research

Pharmacological and toxicological activity of RSD921, a novel sodium channel blocker.
CONCLUSIONS: RSD921 primarily blocks sodium currents, and possesses antiarrhythmic and local anaesthetic activity. PMID: 29990839 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Walker MJA, Hayes ES, Saint DA, Adaikan G, Abraham S, Goldin AL, Beatch GN, MacLeod BA, Wall RA, Pugsley MK Tags: Biomed Pharmacother Source Type: research

miR-125a-3p is responsible for chemosensitivity in PDAC by inhibiting epithelial-mesenchymal transition via Fyn.
CONCLUSION: Our study is the first to show that miR-125a-3p is responsible for chemosensitivity in PDAC and could inhibit epithelial-mesenchymal transition by directly targeting Fyn. This provides a novel potential therapeutic strategy to overcome chemoresistance in PDAC. PMID: 29990840 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Liu G, Ji L, Ke M, Ou Z, Tang N, Li Y Tags: Biomed Pharmacother Source Type: research

C-phycocyanin to overcome the multidrug resistance phenotype in human erythroleukemias with or without interaction with ABC transporters.
, Votto APS Abstract The phenotype of multidrug resistance (MDR) is one of the main causes of chemotherapy failure. Our study investigated the effect of C-phycocyanin (C-PC) in three human erythroleukemia cell lines with or without the MDR phenotype: K562 (non-MDR; no overexpression of drug efflux proteins), K562-Lucena (MDR; overexpression of ATP-binding cassette, sub-family B/ABCB1), and FEPS (MDR; overexpression of ABCB1 and ATP-binding cassette, sub-family C/ABCC1). Using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, we showed that 20 and 200 μg/mL C-PC decreased K562 viabl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Fernandes E Silva E, Figueira FS, Cañedo AD, Machado KS, Salgado MTSF, Silva TK, Wagner EF, Mattozo FH, Lima ÉA, Sales-Neto JM, Ferreira VU, Comitre AA, Mascarenhas SR, Kalil SJ, Votto APS Tags: Biomed Pharmacother Source Type: research

LncRNA-NR_033515 promotes proliferation, fibrogenesis and epithelial-to-mesenchymal transition by targeting miR-743b-5p in diabetic nephropathy.
Abstract Diabetic nephropathy (DN) is a crucial microvascular complication of diabetes. Long non-coding RNAs (lncRNAs) participate in the occurrence and development of various diseases, but the function and regular mechanism of lncRNA-NR_033515 in DN is still unclear. In the present study, we demonstrated that the expression of NR_033515 was significantly increased in the serum of DN patients and was related to the different stages of DN. NR_033515 was also positively associated with diagnostic markers of DN (KIM-1 and NGAL). Overexpression of NR_033515 promoted proliferation, and inhibited apoptosis of MMC cells ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Gao J, Wang W, Wang F, Guo C Tags: Biomed Pharmacother Source Type: research

A molecular approach in drug development for Alzheimer's disease.
Abstract An increase in dementia numbers and global trends in population aging across the world prompts the need for new medications to treat the complex biological dysfunctions, such as neurodegeneration associated with dementia. Alzheimer's disease (AD) is the most common form of dementia. Cholinergic signaling, which is important in cognition, is slowly lost in AD, so the first line therapy is to treat symptoms with acetylcholinesterase inhibitors to increase levels of acetylcholine. Out of five available FDA-approved AD medications, donepezil, galantamine and rivastigmine are cholinesterase inhibitors while me...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Agatonovic-Kustrin S, Kettle C, Morton DW Tags: Biomed Pharmacother Source Type: research

Effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats.
This study examined the effects of amlodipine and valsartan on glibenclamide-treated streptozotocin-induced diabetic rats. Male albino rats (200-350 g) were fasted overnight and DM was induced by a single dose 40 mg/kg of streptozotocin (i.p.). After 48 h, DM was confirmed (blood sugar ≥200 mg/dl) and the animals were grouped into normal rats with no drug treatment, untreated diabetic animals and groups treated with glibenclamide, glibenclamide plus amlodipine, and glibenclamide plus valsartan. After six weeks treatment, animals were sacrificed under chloroform anaesthesia. Kidney, liver, lung, heart and blood w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Bolanle IO, Omogbai EKI, Bafor EE Tags: Biomed Pharmacother Source Type: research

Amelioration of neurodegeneration and cognitive impairment by Lemon oil in experimental model of Stressed mice.
Abstract Citrous lemon (Rutaceae) an Indian folk medicine has been used for the treatment of various pathological diseases viz., diabetes, cardiovascular, inflammation, hepatobiliary dysfunction and neurodegenerative disorder. Can lemon oil altered the memory of unstressed and stressed mice, a basic question for which the present work was put on trial. The present investigation was intended to assess the impact of Lemon oil on memory of unstressed and Stressed Swiss young Albino mice. Lemon oil (50 and 100 mg/kg o.r.) and donepezil (10 mg/kg) were guided for three weeks to different groups of stressed and unst...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Falls N, Singh D, Anwar F, Verma A, Kumar V Tags: Biomed Pharmacother Source Type: research

Emerging role of lncRNAs in systemic lupus erythematosus.
Abstract Long non-coding RNAs (lncRNAs), defined as ≥200 base pairs in length but have little translation potential, play a key role in imprinting control, immune cell differentiation, apoptosis and immune responses. Recently, many potential lncRNAs have been revealed to contribute to a new layer of molecular regulation of systemic lupus erythematosus (SLE). Immune-related functional lncRNAs may serve as novel therapeutic targets and disease biomarkers to provide potential support for clinic treatment in this disease. In this review, we will briefly introduce the identification, biogenesis and functions of lncR...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 2, 2018 Category: Drugs & Pharmacology Authors: Zhao CN, Mao YM, Liu LN, Li XM, Wang DG, Pan HF Tags: Biomed Pharmacother Source Type: research

MiR-876-5p suppresses cell proliferation by targeting Angiopoietin-1 in the psoriasis.
Abstract Psoriasis is an autoimmune disease characterized by abnormal differentiation and hyper-proliferation of epidermal keratinocytes. The object of the study is to investigate the role of miRNA-876-5p in psoriasis. It reported that MicroRNAs (miRNAs) played roles in the malignant progression in psoriasis development. The expression of miR-876-5p was found to be down-regulated in psoriasic tissue and blood of patients. The luciferase assay verified the targeting role of miR-876-5p to 3'UTR of Angiopoietin-1 (Ang-1). Proliferation of psoriasic cells were inhibited by miR-876-5p and hold on G0/G1 phase. Further s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: A R, Yu P, Hao S, Li Y Tags: Biomed Pharmacother Source Type: research

Bis (3-bromo-4,5-dihydroxybenzyl) ether, a novel bromophenol from the marine red alga Polysiphonia morrowii that suppresses LPS-induced inflammatory response by inhibiting ROS-mediated ERK signaling pathway in RAW 264.7 macrophages.
Abstract Inflammation is a pathophysiological defense response against various factors for maintaining homeostasis in the body. However, when continued excessive inflammation becomes chronic, various chronic diseases can develop. Therefore, effective treatment before chronic inflammation development is essential. Bis (3-bromo-4,5-dihydroxybenzyl) ether (BBDE, C14H12Br2O5) is a novel bromophenol isolated from the red alga Polysiphonia morrowii. The beneficial physiological functions of various bromophenols are known, but whether BBDE has beneficial physiological functions is unknown. Therefore, we first investigate...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: Choi YK, Ye BR, Kim EA, Kim J, Kim MS, Lee WW, Ahn GN, Kang N, Jung WK, Heo SJ Tags: Biomed Pharmacother Source Type: research

Therapeutic efficacy of olfactory stem cells in rotenone induced Parkinsonism in adult male albino rats.
CONCLUSION: These results indicate that, the isolated rat OSCs can proliferate and expand in vitro when culture in suitable medium and these cells can exert therapeutic effects in Parkinsonism by recruitment in SN and restoration of the structure and function of dopaminergic cells. PMID: 29864896 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: Abdel-Rahman M, Galhom RA, Nasr El-Din WA, Mohammed Ali MH, Abdel-Hamid AES Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA CRNDE promotes heptaocellular carcinoma cell proliferation by regulating PI3K/Akt / β-catenin signaling.
In conclusion, our findings enlarged our knowledge in the roles of lncRNAs in the progression of HCC and CRNDE as a lncRNA could be a novel target for HCC treatment. PMID: 29864897 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 7, 2018 Category: Drugs & Pharmacology Authors: Tang Q, Zheng X, Zhang J Tags: Biomed Pharmacother Source Type: research