Corrigendum to "Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo" [Biomed. Pharmacother. 97 (2018) 481-488].
Corrigendum to "Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo" [Biomed. Pharmacother. 97 (2018) 481-488]. Biomed Pharmacother. 2019 Oct 12;:109448 Authors: Zheng L, Yin L, Xu L, Qi Y, Li H, Youwei X, Han X, Liu K, Peng J PMID: 31615697 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 12, 2019 Category: Drugs & Pharmacology Authors: Zheng L, Yin L, Xu L, Qi Y, Li H, Youwei X, Han X, Liu K, Peng J Tags: Biomed Pharmacother Source Type: research

Platycodon grandiflorus enhances the effect of DDP against lung cancer by down regulating PI3K/Akt signaling pathway.
Abstract Cisplatin (DDP) is a first-line drug for non-small cell lung cancer (NSCLC), but its efficacy and applications are constrained by intolerance and serious side effects. Platycodon grandiflorus (PG) is usually used as lung medicinal drug to enhance other drug's effect on lung diseases. Therefore, present study aim to investigate anti-NSCLC effect of PG with DDP and mechanism involved in the combination for the first time. The results showed that compared with DDP group, the combined groups (DDP combined with 1, 2 and 4 g/kg of PG) reduced the tumor luminescence density by 26.0%, 78.2% and 32.8% respective...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 11, 2019 Category: Drugs & Pharmacology Authors: Li Y, Wu Y, Xia Q, Zhao Y, Zhao R, Deng S Tags: Biomed Pharmacother Source Type: research

Potential skin protective effects after UVB irradiation afforded by an antioxidant peptide from Odorrana andersonii.
Abstract With increasing demand, the development of new natural antioxidants has become a primary direction of scientific research. We previously identified a short gene-encoded peptide (OA-VI12) from Odorrana andersonii frog skin secretions that exerted direct scavenging capacity against free radicals, suggesting a possible function in protecting skin against photodamage caused by their high-altitude habitat. In the current research, we examined the effects of OA-VI12 on both UVB-irradiation and hydrogen peroxide-induced oxidative stress models established with human immortalized keratinocytes. In addition, we id...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 11, 2019 Category: Drugs & Pharmacology Authors: Yin S, Wang Y, Liu N, Yang M, Hu Y, Li X, Fu Y, Luo M, Sun J, Yang X Tags: Biomed Pharmacother Source Type: research

Antitumor effects of disulfiram/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel.
Abstract The enhancement of the anticancer activity by disulfiram (DSF) chelated with copper (DSF/Cu2+) has been investigated recently, while the underlying molecular mechanisms still need to be fully elucidated. Chloride channel-3 (ClC-3) is over-expressed in a variety of cancers and involves multiple tumor biological events. However, whether the over-expression of ClC-3 in tumor cells affects the sensitivity of anti-tumor drugs remains unclear. Here, we showed that the involvement of ClC-3 chloride channel in the selective cytotoxicity of DSF/Cu2+ in the poorly-differentiated nasopharyngeal carcinoma. The EC50 o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 10, 2019 Category: Drugs & Pharmacology Authors: Xu X, Xu J, Zhao C, Hou X, Li M, Wang L, Chen L, Chen Y, Zhu L, Yang H Tags: Biomed Pharmacother Source Type: research

Investigation of candidate molecular biomarkers for expression profile analysis of the Gene expression omnibus (GEO) in acute lymphocytic leukemia (ALL).
Abstract Much progress has been made in understanding the mechanism of acute lymphocytic leukemia (ALL). However, for adult ALL, there is still a lack of an effective treatment. In the present study, we first used the Gene Expression Omnibus (GEO) database to identify differentially expressed genes (DEGs) between ALL cell lines and Hodgkin and non-Hodgkin cell lines. Then, the GEO database was also used to detect the DEGs in acute lymphoblastic leukemia (Reh) cells transfected with a normal control or a constitutively active variant of the IkB kinase β. Finally, we found that three key DEGs (CCL5, FSCN1, and ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 10, 2019 Category: Drugs & Pharmacology Authors: Zhang G, Wang H, Zhu K, Yang Y, Li J, Jiang H, Liu Z Tags: Biomed Pharmacother Source Type: research

Picroside II, an iridoid glycoside from Picrorhiza kurroa, suppresses tumor migration, invasion, and angiogenesis in vitro and in vivo.
In conclusion, our results demonstrated that PII effectively inhibited the metastasis and angiogenesis of cancer cells both in vitro and in vivo, and thus, might be a novel candidate for cancer therapy. PMID: 31606622 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 10, 2019 Category: Drugs & Pharmacology Authors: Lou C, Zhu Z, Xu X, Zhu R, Sheng Y, Zhao H Tags: Biomed Pharmacother Source Type: research

Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182/NPTX1 axis.
Abstract Circular RNAs (circRNAs) have recently been shown to play critical roles in tumorigenesis. However, the roles of circRNAs in hepatocellular carcinoma (HCC) remain largely unknown. In the present study, we identified a novel circRNA (hsa_circ_0070269) was significantly decreased in HCC tissues and cell lines, low hsa_circ_0070269 expression was positively associated with advanced tumor stage, lymph node metastasis, and poor overall survival. Hsa_circ_0070269 overexpression suppressed proliferation and invasion of HCC cells in vitro and reduced tumor growth in vivo. Mechanistically, hsa_circ_0070269 increas...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 9, 2019 Category: Drugs & Pharmacology Authors: Xiaotong S, Jutong S, Hua H, Zhan Y, Haichao L Tags: Biomed Pharmacother Source Type: research

Liraglutide improves vascular dysfunction by regulating a cAMP-independent PKA-AMPK pathway in perivascular adipose tissue in obese mice.
CONCLUSIONS: Liraglutide improved vascular dysfunction by modulating a cAMP-independent PKA-AMPK pathway in PVAT in HFD-induced obese mice. The findings provide a novel mechanism for the cardiovascular protection of liraglutide by modulating PVAT function in obesity. PMID: 31605951 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 9, 2019 Category: Drugs & Pharmacology Authors: Han F, Hou N, Liu Y, Huang N, Pan R, Zhang X, Mao E, Sun X Tags: Biomed Pharmacother Source Type: research

Reversal of drug resistance by JS-K and nitric oxide in ABCB1- and ABCG2-expressing multi-drug resistant human tumor cells.
In this study, we used [O2-(2,4-dinitrophenyl)-1-[(4-ethoxycarbonyl)-piperazin-1 yl]-diazene-1-ium-1-2-diolate] (JS-K), a tumor-specific NO-donor to study the reversal of drug resistance in both P-gp- and BCRP-overexpressing human tumor cells. We report here that while JS-K was extremely effective in reversing adriamycin resistance in the P-gp-overexpressing tumor cells (NCI/ADR-RES); it was significantly resistant to BCRP-overexpressing (MCF-7/MX) tumor cells, suggesting that JS-K may be a substrate for BCRP. Using another NO-donor (DETNO), we show that NO directly inhibits the ATP activities of BCRP, inducing significa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 9, 2019 Category: Drugs & Pharmacology Authors: Sinha BK, Perera L, Cannon RE Tags: Biomed Pharmacother Source Type: research

Dual roles of glutathione S-transferase mu 1 in the development and metastasis of hepatocellular carcinoma.
CONCLUSION: GSTM1 down-regulation may partially account for ROS-mediated oxidative damage and HCC carcinogenesis. GSTM1 also regulates tumor progression by disrupting the ROS-TP53 axis in HCC cells with different genetic backgrounds. PMID: 31605953 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 9, 2019 Category: Drugs & Pharmacology Authors: Lu Y, Zhou J, Zhang J, Wang Z, Yu Y, Miao M, Yao Q Tags: Biomed Pharmacother Source Type: research

Selective chemical ablation of transient receptor potential vanilloid 1 expressing neurons in the left stellate ganglion protects against ischemia-induced ventricular arrhythmias in dogs.
CONCLUSION: Targeted ablation of TRPV-1/TH positive sympathetic neurons induced by RTX stellate microinjection could suppress ischemia-induced cardiac autonomic imbalances and cardiac electrophysiology instability to protect against AMI-induced VAs. PMID: 31600641 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 7, 2019 Category: Drugs & Pharmacology Authors: Zhou M, Liu Y, He Y, Xie K, Quan D, Tang Y, Huang H, Huang C Tags: Biomed Pharmacother Source Type: research

Effectiveness of absorption and passage through the small intestine, as a model of oral prolactin administration.
Abstract The process of absorption and permeation of PRL through the small intestine of 1-day-old piglet from the different compositions of solutions prepared for oral administration was investigated. This was achieved by determining the effect of hormone concentration (0.25 mg / ml or 0.5 mg / ml or 0.75 mg / ml), the concentration of stabilizing substances - trehalose (6 mg / ml or 12 mg / ml or 18 mg / ml) and mannitol (6 mg / ml or 12 mg / ml or 18 mg / ml) and the pH of the solution (2.5 or 3.0 or 3.5) on the degree of absorption and permeation of the PRL. The conditions for the absorption a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 7, 2019 Category: Drugs & Pharmacology Authors: Dolińska B, Siemiradzka W, Ryszka F Tags: Biomed Pharmacother Source Type: research

Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis.
Abstract Vascular dementia (VD) is a degenerative cerebrovascular disorder, leading to progressive decline of cognitive abilities and memory. Rehmannioside A (ReA) is isolated from Rehmanniae Radix, which exhibits protective role against various diseases. The present study was performed to calculate the possible neuroprotective effects of ReA on VD. Here, the morris water maze (MWM) test and electrophysiological recordings indicated that ReA reduced cognitive deficits. Additionally, through hematoxylin and eosin (H&E) and Nissl staining, ReA attenuated the histological alterations of hippocampus in rats with V...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 5, 2019 Category: Drugs & Pharmacology Authors: Sun M, Shen X, Ma Y Tags: Biomed Pharmacother Source Type: research

Diagnosis and Management of Immune Related Adverse Events (irAEs) in Cancer Immunotherapy.
Abstract Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell therapy are two main promising methods of immunotherapy, which have become increasingly important in cancer treatment. After the wider application of these medicine in clinic, a range of immune related adverse events (irAEs) covering almost any system arouse the concern for being randomness and unpredictability. Even if most adverse events are mild and controllable after thoughtful management, the occurrence of life-threatening toxicities should not be ignored because of the insidious and atypical symptoms, which makes the ear...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 4, 2019 Category: Drugs & Pharmacology Authors: Liu YH, Zang XY, Wang JC, Huang SS, Xu J, Zhang P Tags: Biomed Pharmacother Source Type: research

Fufang Xueshuantong protects retinal vascular endothelial cells from high glucose by targeting YAP.
Abstract Fufang Xueshuantong (FXST), a Chinese patent medicine, is composed of Panax notoginseng, Salviae miltiorrhizae, Astragali Radix and Radix Scrophulariae and has been found to prevent diabetic retinopathy. Yes-associated protein (YAP) participates in the pathophysiology of retinal disease and promotes endothelial cell proliferation and angiogenesis. Although it is known that YAP activity is altered by FXST, the role of YAP in mediating the effect of FXST remains unclear. In high glucose-treated retinal vascular endothelial cells (RVECs), FXST significantly reduced cell viability, the number of migrating cel...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 4, 2019 Category: Drugs & Pharmacology Authors: Xing W, Song Y, Li H, Wang Z, Wu Y, Li C, Wang Y, Liu Y, Wang W, Han J Tags: Biomed Pharmacother Source Type: research

LINC01234 facilitates growth and invasiveness of oral squamous cell carcinoma through regulating the miR-637/NUPR1 axis.
Abstract LINC01234 plays a pivot role in the tumorigenesis of gastric cancer, colon cancer and lung cancer. However, how LINC01234 participates in oral squamous cell carcinoma (OSCC) progression remains unknown. In our research, we showed that LINC01234 was dramatically upregulated in OSCC tissues. And interestingly, high LINC01234 expression predicted a low overall survival rate in OSCC patients. Knockdown of OSCC inhibited the proliferation of cancer cells and led to more cells restricted in G0 phase. Moreover, LINC01234 silencing decreased the migration and invasion of OSCC cells. Additionally, downregulation o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 4, 2019 Category: Drugs & Pharmacology Authors: Huang W, Cao J, Peng X Tags: Biomed Pharmacother Source Type: research

Nr2e1 ablation impairs liver glucolipid metabolism and induces inflammation, high-fat diets amplify the damage.
In conclusion, Nr2e1 ablation promotes liver steatosis and systemic insulin resistance. Nr2e1 may play a protective role in the formation of NAFLD and may serve as a worthy therapeutic target for NAFLD. PMID: 31590127 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 4, 2019 Category: Drugs & Pharmacology Authors: Xiong Q, Wu Y, Yang M, Wu G, Wang Y, Wang H, Feng J, Song L, Tong B, He G, Xu Y Tags: Biomed Pharmacother Source Type: research

HIF-1 α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
CONCLUSIONS: Together, our studies indicated that HIF-1α synchronization regulate BNIP3 during OGD/R injury-induced autophagy in H9C2 cells, though BNIP3-induced autophagy acting as a survival mechanism. PMID: 31590128 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 4, 2019 Category: Drugs & Pharmacology Authors: Zhang Y, Liu D, Hu H, Zhang P, Xie R, Cui W Tags: Biomed Pharmacother Source Type: research

Adipose tissue as a possible therapeutic target for polyphenols: A case for Cyclopia extracts as anti-obesity nutraceuticals.
Abstract Obesity is a significant contributor to increased morbidity and premature mortality due to increasing the risk of many chronic metabolic diseases such as type 2 diabetes, cardiovascular disease and certain types of cancer. Lifestyle modifications such as energy restriction and increased physical activity are highly effective first-line treatment strategies used in the management of obesity. However, adherence to these behavioral changes is poor, with an increased reliance on synthetic drugs, which unfortunately are plagued by adverse effects. The identification of new and safer anti-obesity agents is thus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Jack BU, Malherbe CJ, Mamushi M, Muller CJF, Joubert E, Louw J, Pheiffer C Tags: Biomed Pharmacother Source Type: research

Exosomes in ischemic heart disease: novel carriers for bioinformation.
Abstract The occurrence of ischemic heart disease(IHD) is a multi-step chain process from potential risk factors to overt clinical diseases. Vascular cells, blood cells, cardiomyocytes and stem cells are all involved in the pathophysiological links via continual and polynary crosstalk. Exosomes,as powerful vectors for intercellular communication,have been a hotspot for basic and clinical research. Plenty of evidence has shown that exosomes largely participate in the evolution of IHD, including endothelial dysfunction, lipid deposition, atheromatous plaque formation and rupture, myocardial ischemia-reperfusion(I/R)...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Zhou H, Wang B, Yang Y, Jia Q, Qi Z, Zhang A, Lv S, Zhang J Tags: Biomed Pharmacother Source Type: research

Betaine alleviates alcohol-induced osteonecrosis of the femoral head via mTOR signaling pathway regulation.
In this study, we hypothesized that betaine might have protective effects on ethanol-treated BMSCs and decrease the morbidity of alcohol-induced ONFH in a rat model. In vitro, we found that ethanol significantly downregulated the expression of osteocalcin (OCN), collagen 1 (COL1) and RUNX2 via activating the mammalian target of rapamycin (mTOR) signaling cascade. However, the inhibitory effects were rescued by betaine co-treatment at concentrations of 1 mM and 10 mM. In vivo, the typical ONFH pathological changes in a rat model of alcohol-induced ONFH were investigated by using multiple methods, including hem...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Yang Q, Yin W, Chen Y, Zhu D, Yin J, Zhang C, Gao Y Tags: Biomed Pharmacother Source Type: research

Non-small cell lung cancer-targeted, redox-sensitive lipid-polymer hybrid nanoparticles for the delivery of a second-generation irreversible epidermal growth factor inhibitor-Afatinib: In vitro and in vivo evaluation.
Abstract Afatinib (Afa), a second-generation irreversible epidermal growth factor inhibitor for the development of non-small cell lung cancer, has low bioavailability and adverse reactions. Nanoscaled drug delivery systems offer promising alternatives to address these defects and improve therapeutic outcomes. In the present study, a Tf contained, redox-sensitive ligand was synthesized and used for the preparation of afatinib loaded, Tf modified redox-sensitive lipid-polymer hybrid nanoparticles (Tf-SS-Afa-LPNs). Subsequently, studies of biological experiments in vitro and in vivo were performed to investigate the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Wang J, Su G, Yin X, Luo J, Gu R, Wang S, Feng J, Chen B Tags: Biomed Pharmacother Source Type: research

Epigallocatechin-3-gallate inhibits tumor angiogenesis: involvement of endoglin/Smad1 signaling in human umbilical vein endothelium cells.
Abstract Strategies targeting endoglin are currently being investigated in clinical trials as an anti-angiogenic therapy. The redundancy between endoglin and vascular endothelial growth factor (VEGF) signaling in angiogenesis was verified. Increased endoglin signaling after an anti-VEGF treatment was observed in patients. Treatment with an endoglin-neutralizing antibody increased VEGF signaling in endothelial cells. Therefore, strategies targeting both the endoglin and VEGF pathways were applied to determine whether the anti-angiogenic effects were increased in vitro. Five possible hits for endoglin were identifie...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Chen CY, Lin YJ, Wang CCN, Lan YH, Lan SJ, Sheu MJ Tags: Biomed Pharmacother Source Type: research

Anti-tumor effects and associated molecular mechanisms of myricetin.
Abstract Myricetin (3, 5, 7, 3', 4', 5'-hexahydroxyflavone) is a natural flavonol compound found in a large variety of plants, including berries, oranges, grapes, herbs, teas, and wine. In the last decade, a convergence of evidence has demonstrated that myricetin has good biological activity as an anti-tumor, anti-inflammatory, and anti-oxidation agent. In studies involving various types of cancer cells, myricetin has been shown to suppress cancer cell invasion and metastasis, to induce cell cycle arrest and apoptosis of cancer cells, and to inhibit their proliferation. These findings have raised interest in myric...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Jiang M, Zhu M, Wang L, Yu S Tags: Biomed Pharmacother Source Type: research

Voltage-gated sodium channel inhibitor reduces atherosclerosis by modulating monocyte/macrophage subsets and suppressing macrophage proliferation.
In conclusion, blockade of VGSCs in the mononuclear phagocyte system reduced atherosclerotic lesions, which may occur through altering monocyte/macrophage subsets and suppressing macrophage proliferation in atherosclerotic plaques. Blockage of VGSCs may play an important role in cardiovascular protection. PMID: 31586905 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Sun H, Jiang J, Gong L, Li X, Yang Y, Luo Y, Guo Z, Lu R, Li H, Li J, Zhao J, Yang N, Li Y Tags: Biomed Pharmacother Source Type: research

Glycyrrhizic acid ammonium salt alleviates Concanavalin A-induced immunological liver injury in mice through the regulation of the balance of immune cells and the inhibition of hepatocyte apoptosis.
This study may provide a new strategy for the treatment of immune-mediated liver injury. PMID: 31586906 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2019 Category: Drugs & Pharmacology Authors: Tian X, Liu Y, Liu X, Gao S, Sun X Tags: Biomed Pharmacother Source Type: research

Protective effects of betaine on diabetic induced disruption of the male mice blood-testis barrier by regulating oxidative stress-mediated p38 MAPK pathways.
In conclusion, these results demonstrated that BET exerts protective effects on diabetes-induced BTB dysfunction, which may be through regulating oxidative stress-mediated p38 MAPK pathways. PMID: 31585299 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2019 Category: Drugs & Pharmacology Authors: Jiang YP, Yang JM, Ye RJ, Liu N, Zhang WJ, Ma L, Zheng P, Niu JG, Liu P, Yu JQ Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA MEG3 regulates migration and invasion of lung cancer stem cells via miR-650/SLC34A2 axis.
Abstract Long non-coding RNA maternally expressed gene 3 (MEG3) is related to the occurrence and development of non-small cell lung cancer (NSCLC). However, the function and underlying molecular mechanisms of MEG3 in lung cancer stem cells (LCSCs) are still unclear. LCSCs were determined in lung cancer cells using fluorescence-activated cell sorting (FACS). qRT-PCR and western blot were performed to examine the expressions of MEG3, miR-650, solute carrier family 34 member 2 (SLC34A2), octamer-binding transcription factor 4 (Oct4), and CD133. Sphere assay was employed to evaluate sphere-forming ability. Cell migrat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2019 Category: Drugs & Pharmacology Authors: Zhao Y, Zhu Z, Shi S, Wang J, Li N Tags: Biomed Pharmacother Source Type: research

UCA1 long non-coding RNA: An update on its roles in malignant behavior of cancers.
Abstract The lncRNA urothelial carcinoma-associated 1 (UCA1) is a 1.4 kb long transcript which has been firstly recognized in human bladder cancer cell line. Subsequent studies revealed its over-expression in a wide array of human cancer cell lines and patients' samples. In addition to conferring malignant phenotype to cells, it enhances resistance to conventional anti-cancer drugs. Moreover, transcript levels of this lncRNA have been regarded as diagnostic markers in several cancer types including gastric, bladder and liver cancers. The underlying mechanism of its participation in carcinogenesis has been identi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2019 Category: Drugs & Pharmacology Authors: Ghafouri-Fard S, Taheri M Tags: Biomed Pharmacother Source Type: research

FLT3/FLT3L-mediated CD103+ dendritic cells alleviates hepatic ischemia-reperfusion injury in mice via activation of treg cells.
CONCLUSION: FLT3/FLT3L-induced CD103+ DCs alleviated hepatic IRI through activating Treg cells. PMID: 31545219 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Zhou CZ, Wang RF, Cheng DL, Zhu YJ, Cao Q, Lv WF Tags: Biomed Pharmacother Source Type: research

Mining featured biomarkers associated with vascular invasion in HCC by bioinformatics analysis with TCGA RNA sequencing data.
This study aims to identify the feature genes associated with vascular invasion in hepatocellular carcinoma (HCC). Here, the RNA sequencing data related to vascular invasion in The Cancer Genome Atlas (TCGA) database, including 292 HCC patients with complete clinical data were included in our study as the training dataset for construction and E-TABM-36, including 41 HCC patients with complete clinical data was used as the validation dataset. Following data normalization, differentially expressed mRNA and copy number (CN) were selected between with and without vascular invasion samples. A support vector machine (SVM) classi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Zhang R, Ye J, Huang H, Du X Tags: Biomed Pharmacother Source Type: research

A Malva parviflora ´s fraction prevents the deleterious effects resulting from neuroinflammation.
A Malva parviflora´s fraction prevents the deleterious effects resulting from neuroinflammation. Biomed Pharmacother. 2019 Oct;118:109349 Authors: Ramírez-Serrano CE, Jiménez-Ferrer E, Herrera-Ruiz M, Zamilpa A, Vargas-Villa G, Ramírez-Carreto RJ, Chavarría A, Tortoriello J, Pedraza-Alva G, Pérez-Martínez L Abstract Neuroinflammation, a centralized immune response, is a physiological process by which the organism attempts to remove an injurious stimulus in the central nervous system. Nonetheless, it is known that chronic inflammatory processes play an im...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Ramírez-Serrano CE, Jiménez-Ferrer E, Herrera-Ruiz M, Zamilpa A, Vargas-Villa G, Ramírez-Carreto RJ, Chavarría A, Tortoriello J, Pedraza-Alva G, Pérez-Martínez L Tags: Biomed Pharmacother Source Type: research

Embelin can protect mice from thioacetamide-induced acute liver injury.
CONCLUSIONS: In summary, embelin can protect against acute liver injury. Its therapeutic value warrants further exploration. PMID: 31545222 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Wang H, Zhang H, Wang Y, Yang L, Wang D Tags: Biomed Pharmacother Source Type: research

The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques.
This study investigated the value of using ultrasound-targeted microbubble destruction (UTMD) to deliver an IL-8 monoclonal antibody to inhibit the inflammatory response and increase plaque stability in a rabbit model of atherosclerosis (AS). An abdominal aortic atherosclerotic plaque model was established in sixty 4-week-old male New Zealand rabbits. The rabbits were fed a high-fat diet for 12 weeks. On the 12th week, the abdominal aorta was subjected to both balloon-induced mechanical injury and bovine serum albumin-induced immunological injury. After these injuries were established, the rabbits were fed a high-fat diet ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Yang H, Sun Y, Wei J, Xu L, Tang Y, Yang L, Zhang X, Lu Y Tags: Biomed Pharmacother Source Type: research

Expression of GR- α and HDAC2 in steroid-Sensitive and steroid-Insensitive interstitial lung disease.
CONCLUSION: HDAC2 and GR-α expression in lung tissues are potential biomarkers for predicting corticosteroid sensitivity when initially treating COP and IPF, as well as other forms of ILD. PMID: 31545224 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Bin YF, Wu LJ, Sun XJ, Liang Y, Bai J, Zhang JQ, Li MH, Zhong XN, Liang YJ, He ZY Tags: Biomed Pharmacother Source Type: research

Ardisia crispa root hexane fraction suppressed angiogenesis in human umbilical vein endothelial cells (HUVECs) and in vivo zebrafish embryo model.
Abstract Ardisia crispa Thunb. A. DC. (Primulaceae) has been used extensively as folk-lore medicine in South East Asia including China and Japan to treat various inflammatory related diseases. Ardisia crispa root hexane fraction (ACRH) has been thoroughly studied by our group and it has been shown to exhibit anti-inflammatory, anti-hyperalgesic, anti-arthritic, anti-ulcer, chemoprevention and suppression against inflammation-induced angiogenesis in various animal model. Nevertheless, its effect against human endothelial cells in vitro has not been reported yet. Hence, the aim of the study is to investigate the pot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Wen Jun L, Pit Foong C, Abd Hamid R Tags: Biomed Pharmacother Source Type: research

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.
In this study, we administered either berberine or metformin to db/db mice and investigated changes in body weight, food intake, and blood glucose levels. Fresh stool samples were analyzed using 16 s rDNA high-throughput sequencing to evaluate the gut microbiome. Short-chain fatty acids (SCFA) in the stool were quantified using gas chromatography. The expression of NF-κB signaling pathway and tight junction (ZO1 and occludin) proteins in the intestinal epithelium was determined using qPCR and western blotting. The intestinal barrier structure was examined using transmission electron microscopy and serum lipopolysac...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Zhang W, Xu JH, Yu T, Chen QK Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA LUCAT1 promotes proliferation and invasion in gastric cancer by regulating miR-134-5p/YWHAZ axis.
CONCLUSIONS: LncRNA LUCAT1 could promote proliferation and invasion of gastric cancer by regulating miR-134-5p/YWHAZ axis. PMID: 31545227 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Chi J, Liu T, Shi C, Luo H, Wu Z, Xiong B, Liu S, Zeng Y Tags: Biomed Pharmacother Source Type: research

Enhancement of anticancer activity of docetaxel by combination with Fuzheng Yiliu decoction in a mouse model of castration-resistant prostate cancer.
Abstract Docetaxel (Doc) is the gold standard of care for castration-resistant prostate cancer (CRPC) patients, although the therapeutic effects are modest. Fuzheng Yiliu decoction (FZYL) comprises multiple herbs, and has been used for>10 years to treat various cancers, including hepatocellular tumors, malignant gastrointestinal tumors, and prostate cancer. In the study reported, we evaluated the anticancer effects of FZYL and of a combination of Doc and FZYL in CRPC tumor-bearing mice, and explored the underlying mechanisms. PC-3 tumor-bearing mice were treated with FZYL, Doc, Doc + FZYL or vehicle solutio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Fu W, Hong Z, You X, Din J, Chen B, Zhao B, Yuan G, Li Q Tags: Biomed Pharmacother Source Type: research

Increased expression of MMP-2 and MMP-9 indicates poor prognosis in glioma recurrence.
In this study, we assessed the expression of MMP-2, MMP-9, two important matrix metallopeptidases that increase the invasive ability of glioma, and their suppressors, TIMP-1, TIMP-2 in glioma tissues from primary and recurrent glioma patients by immunohistochemistry. Glioma cells and nude mice were used for in vitro and in vivo studies. Results showed that the expression of MMP-2 and MMP-9 in recurrent gliomas were significantly higher than those in primary gliomas (P = 3.075 × 10-11, P = 1.510 × 10-5, respectively). We also found that radiotherapy increased the expression of MMP-9, but had no e...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Zhou W, Yu X, Sun S, Zhang X, Yang W, Zhang J, Zhang X, Jiang Z Tags: Biomed Pharmacother Source Type: research

FAM83H-AS1 is upregulated and predicts poor prognosis in colon cancer.
Abstract Long noncoding RNAs (LncRNAs) have been proven to participate in many principal pathways during colonic mucosa tumourigenesis. FAM83H-AS1 has been identified as one of the LncRNAs that is dysregulated in multi-type cancers. Here, our purpose was to determine the expression pattern and clinical significance of FAM83H-AS1 and further analyse its prognostic value in colon cancer. FAM83H-AS1 expression was examined in 90 patients with colon cancer by RNAscope in situhybridization, and the expression levels were analysed with the overall survival (OS) rates for patients with colon cancer. TCGA datasets derived...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Yang L, Cui J, Wang Y, Tan J Tags: Biomed Pharmacother Source Type: research

MiR-377 mediates the expression of Syk to attenuate atherosclerosis lesion development in ApoE-/- mice.
This study identifies a novel role of miR-377 in AS via targeting Syk. PMID: 31545231 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Guo Y, Huang S, Ma Y, Zhang J, Wen Y, Zhou L, Yuan G, Cheng J Tags: Biomed Pharmacother Source Type: research

An adenosine derivative (IFC-305) reduced the risk of radiation-induced intestinal toxicity in the treatment of colon cancer by suppressing the methylation of PPAR-r promoter.
CONCLUSION: In this study, we demonstrated the relationship between PPAR-r promoter methylation and the risk of radiation-induced intestinal toxicity via studying the clinical samples collected from CC patients. And the study upon mice models suggested that the administration of IFC-305 could alleviate radiation-induced intestinal toxicity through decreasing the methylation of PPAR-r promoter and enhancing the expression of PPAR-r in IR mice. PMID: 31545232 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Lian B, Ren Y, Zhang H, Lin T, Wang Y Tags: Biomed Pharmacother Source Type: research

Let-7f-5p ameliorates inflammation by targeting NLRP3 in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus.
In conclusion, our study suggested that high level of let-7f-5p alleviated inflammation in SLE-BMSCs at least partly through targeting NLRP3, highlighting let-7f-5p as a novel promising therapeutic strategy for SLE treatment. PMID: 31545233 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Tan W, Gu Z, Leng J, Zou X, Chen H, Min F, Zhou W, Zhang L, Li G Tags: Biomed Pharmacother Source Type: research

Chicoric acid (CA) induces autophagy in gastric cancer through promoting endoplasmic reticulum (ER) stress regulated by AMPK.
Abstract Gastric cancer is one of the most common cancers leading to tumor-related deaths worldwide. Chicoric acid (CA) exhibits a variety of protective effects in different diseases. However, its role in regulating tumor progression has not been reported. Autophagy, as a conserved catabolic process, sustains cellular homoeostasis responding to stress to modulate cell fate. In the study, the effects of CA on gastric cancer were investigated. The results indicated that CA treatment markedly reduced the cell viability and induced apoptosis in gastric cancer cells, and prevented tumor growth in an established xenogra...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Sun X, Zhang X, Zhai H, Zhang D, Ma S Tags: Biomed Pharmacother Source Type: research

Effect of catalpol on behavior and neurodevelopment in an ADHD rat model.
Abstract Studies suggest that abnormal neurodevelopment of prefrontal striatal circuits is implicated in the pathogenesis of attention deficit hyperactivity disorder (ADHD). In the present study, we investigated the effect of catalpol, an active ingredient of Rehmanniae radix preparata, which is the most frequently used Chinese medicinal herb for the treatment of ADHD, on behavior and neurodevelopment in spontaneously hypertensive rats (SHR). SHR were divided into SHR group (vehicle, i.g.), methylphenidate (MPH) group (2 mg/kg/day, i.g.), and catalpol group (50 mg/kg/day i.g.), and Wistar-Kyoto (WKY)...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Yuan H, Ni X, Zheng M, Han X, Song Y, Yu M Tags: Biomed Pharmacother Source Type: research

The inhibitory role of Chinese materia medica in cardiomyocyte apoptosis and underlying molecular mechanism.
Abstract Apoptosis is an evolutionarily conserved suicide process. It plays critical roles in the development and homeostasis of cardiac tissues. However, excessively stimulated apoptotic activity induced by a myriad of deleterious stimuli can result in too much cardiomyocyte death. The regenerative potential of the adult cardiomyocytes is limited. The cardiomyocyte loss cannot be compensated by efficient cell proliferation. It inevitably leads to various heart diseases. Therefore, the inhibition of cardiomyocyte apoptosis is an important therapeutic strategy for heart diseases. Chinese materia medica (CMM) has mo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Li Y, Liu X Tags: Biomed Pharmacother Source Type: research

LncRNA FENDRR suppresses the progression of NSCLC via regulating miR-761/TIMP2 axis.
Abstract To explore the roles of long noncoding RNA (lncRNA) FOXF1 Adjacent Non-Coding Developmental Regulatory RNA (FENDRR) in human non-small cell lung cancer (NSCLC). The levels of FENDRR in NSCLC cells and tissues were analyzed using qRT-PCR assay. The growth and colony formation abilities of NSCLC cell were analyzed by the MTT and colony formation tests. The mobility and invasiveness of NSCLC cell were analyzed using the wound closure and Transwell invasion assay. The impact of FENDRR on the tumor growth of NSCLC cells in vivo was detected using xenograft model. Bioinformatics analysis and luciferase reporter...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Zhang G, Wang Q, Zhang X, Ding Z, Liu R Tags: Biomed Pharmacother Source Type: research

Bioactive compounds from herbal medicines to manage dyslipidemia.
Abstract Dyslipidemia is a key risk factor for cardiovascular diseases, which are a major cause of morbidity and mortality worldwide. However, despite the advancement of the treatment and prevention of dyslipidemia, medications used to treat dyslipidemia are limited to chemical drugs. Herbal medicine, as an alternative treatment, has a long history of usage and provides more treatment options, and related studies have revealed intervention targets for dyslipidemia. Four lipid-lowering mechanisms of herbal medicines have been proposed and are discussed in this paper. These mechanisms are the inhibition of cholester...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Ji X, Shi S, Liu B, Shan M, Tang D, Zhang W, Zhang Y, Zhang L, Zhang H, Lu C, Wang Y Tags: Biomed Pharmacother Source Type: research

Investigating the effects and possible mechanisms of danshen- honghua herb pair on acute myocardial ischemia induced by isoproterenol in rats.
This study was focused on examining the effects and possible mechanisms of DHHP in rats with acute myocardial ischemia induced by isoproterenol (ISO). The results suggested that DHHP significantly ameliorated the myocardial tissue abnormalities, notablely inhibited the elevation of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), creatinekinase isoenzyme (CK-MB) and cardiac troponin T (CTn-T) in plasma, obviously decreased the plasma levels of Tumor Necrosis Factor α (TNF-α), outstandingly inhibited the reduction of superoxide dismutase (SOD), catalase (CAT) caused by ISO, si...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 25, 2019 Category: Drugs & Pharmacology Authors: Wang XP, Wang PF, Bai JQ, Gao S, Wang YH, Quan LN, Wang F, Wang XT, Wang J, Xie YD Tags: Biomed Pharmacother Source Type: research