Log in to search using one of your social media accounts:

 

Angiotensin IV improves subnormothermic machine perfusion preservation of rat liver graft.
In conclusion, we showed that the use of Ang IV in Celsior solution for sub-normothermic graft preservation insured a better NO-dependent relaxation and improved liver functional recovery. PMID: 29609847 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 30, 2018 Category: Drugs & Pharmacology Authors: Tabka D, Bejaoui M, Javellaud J, Achard JM, Ben Abdennebi H Tags: Biomed Pharmacother Source Type: research

Perinatal exposure to energy drink induces oxidative damage in the liver, kidney and brain, and behavioral alterations in mice offspring.
In conclusion, perinatal exposure to EDs induces oxidative stress, tissue injury and behavioral alterations in the mice newborns. Therefore, the consumption of EDs during pregnancy and lactation has a negative impact on the newborns and should be treated as a significant health problem that warrants attention. PMID: 29605768 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Al-Basher GI, Aljabal H, Almeer RS, Allam AA, Mahmoud AM Tags: Biomed Pharmacother Source Type: research

Phytochemicals-induced hormesis protects Caenorhabditis elegans against α-synuclein protein aggregation and stress through modulating HSF-1 and SKN-1/Nrf2 signaling pathways.
In this study, we report that the phytochemicals of Dioscorea alata L., tubers extends the lifespan of nematode model Caenorhabditis elegans by hormetic mechanism. We showed that the low dose of tubers extract at 200 and 300 μg/mL extends the mean lifespan of wild-type worms, whereas higher doses are found to be toxic. Supplementation of tubers extract slightly increased the intracellular ROS in second-day adult worms and it might activate the adaptive stress response, which protects the worms from oxidative and thermal stress. Transgenic reporter gene expression assay showed that extract treatment enhanced the expres...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Govindan S, Amirthalingam M, Duraisamy K, Govindhan T, Sundararaj N, Palanisamy S Tags: Biomed Pharmacother Source Type: research

p-Coumaric acid mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy.
In this study we investigated the effects of pCA on the regulation of Nrf-2, mitochondrial viability, autophagy and apoptosis in Doxorubicin treated H9c2 cardiomyocytes. ROS induced mitochondrial stress, changes in mitochondrial membrane potential, loss of membrane integrity; nuclear damage as single/double stranded breaks, autophagy and the effects of pre and co-treatment of pCA on Nrf-2 mediated signaling was evaluated by various approaches. The effect of pCA on drug uptake was evaluated through confocal Raman Spectroscopy. We find that nuclear translocation of Nrf-2 is prominently marked by protein-specific antibody con...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Sunitha MC, Dhanyakrishnan R, PrakashKumar B, Nevin KG Tags: Biomed Pharmacother Source Type: research

The dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin ameliorates retinal endothelial cell dysfunction triggered by inflammation.
atilde;o A, Fernandes R Abstract Diabetic retinopathy is considered a low-grade chronic inflammatory disease and several inflammatory molecules, including tumor necrosis factor (TNF)-α, are known to play a major role in the degeneration of retinal capillaries. Previous studies have reported that sitagliptin, a DPP-4 inhibitor, prevents the increase in blood-retinal barrier (BRB) permeability and inhibits the tight junction disassembly induced by diabetes. AIM: Our goal was to investigate whether sitagliptin is able to prevent retinal endothelial cells (EC) dysfunction triggered by the pro-inflammatory c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Gonçalves A, Almeida L, Silva AP, Fontes-Ribeiro C, Ambrósio AF, Cristóvão A, Fernandes R Tags: Biomed Pharmacother Source Type: research

NOS1 mediates AP1 nuclear translocation and inflammatory response.
In conclusion, the study shows the novel mechanism of NOS1- mediated AP1 nuclear translocation, which needs to be further explored. PMID: 29605772 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Srivastava M, Baig MS Tags: Biomed Pharmacother Source Type: research

Peel flour of Passiflora edulis Var. Flavicarpa supplementation prevents the insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats.
Abstract The increase in fructose consumption in the last decades has an important correlation with the growth of overweight population. Fructose is a monosaccharide found in fruits, vegetables and honey, however, it is widely used in processed food and beverages such as sweeteners. This monosaccharide is metabolized in the liver, so it can produce glucose, lactate, triglycerides, free fatty acids and uric acid, which are responsible for negative effects on the liver and extrahepatic tissues. One effect of the high consumption of fructose is the resistance to Insulin, which appears to be an important issue in the ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 29, 2018 Category: Drugs & Pharmacology Authors: Goss MJ, Nunes MLO, Machado ID, Merlin L, Macedo NB, Silva AMO, Bresolin TMB, Santin JR Tags: Biomed Pharmacother Source Type: research

Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. The oncogenic function of the long non-coding RNA; metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in HCC remains unclear. We aimed to evaluate MALAT1 serum expression profile in HCC and explore its relation to the clinicopathological features. Quantitative Real Time-Polymerase Chain Reaction was applied in 70 cohorts (30 HCC, 20 HCV, 20 controls). Further meta-analysis of clinical studies and in vitro validated experiments was employed. Serum MALAT1 showed area under the curve of 0.79 and 0.7...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Toraih EA, Ellawindy A, Fala SY, Al Ageeli E, Gouda NS, Fawzy MS, Hosny S Tags: Biomed Pharmacother Source Type: research

Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways.
Abstract Adipocyte differentiation is a critical adaptive response to nutritional overload and affects the metabolic outcome of obesity. Sinigrin (2-propenyl glucosinolate) is a glucosinolate belong to the glucoside contained in broccoli, brussels sprouts, and black mustard seeds. We investigated the effects of sinigrin on adipogenesis in 3T3-L1 preadipocytes and its underlying mechanisms. Sinigrin remarkably inhibited the accumulation of lipid droplets and adipogenesis by downregulating the expression of CCAAT-enhancer-binding protein α (C/EBPα), peroxisome proliferator-activated receptor gamma (PPAR&...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Lee HW, Rhee DK, Kim BO, Pyo S Tags: Biomed Pharmacother Source Type: research

Apigenin enhances the antitumor effects of cetuximab in nasopharyngeal carcinoma by inhibiting EGFR signaling.
Abstract Nasopharyngeal carcinoma (NPC) is a type of head and neck cancers with poor prognosis. Despite that platinum-based chemotherapy concurrent with radiotherapy have made great achievements for the treatment of NPC, the therapeutic reaction and toxicity varies dramatically among individuals. Apigenin (API), a naturally occurring plant flavone, is considered to have anti-cancer effect. Cetuximab (CET), a well known epidermal growth factor receptor (EGFR) inhibitor, is widely used in various cancers, especially head and neck cancers. The aim of our study was to measure the combination of API and CET for the tre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Hu WJ, Liu J, Zhong LK, Wang J Tags: Biomed Pharmacother Source Type: research

Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases.
We present a comprehensive review regarding the oxidative stress and protective effects of silymarin in CVDs management. We also aim to provide mechanistic insight of the mechanisms of silymarin action in oxidative stress-induced CVDs. PMID: 29604588 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Taleb A, Ahmad KA, Ihsan AU, Qu J, Lin N, Hezam K, Koju N, Hui L, Qilong D Tags: Biomed Pharmacother Source Type: research

Oncosis-like cell death is induced by berberine through ERK1/2-mediated impairment of mitochondrial aerobic respiration in gliomas.
Abstract Gliomas, the most common primary malignant brain tumor, exhibit high metabolic activity. The targeting of metabolism alterations, particularly in mitochondria, is emerging as an efficient approach for curing cancers. Here, we showed that berberine, a natural compound that is used as an antibacterial agent, could reduce cellular viability and induce oncosis-like death, characterized by cell swelling, cytoplasmic vacuoles and plasma membrane blebbing, in gliomas, and that these effects were correlated with intracellular adenosine triphosphate (ATP) depletion. We also found that berberine induced autophagy a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Sun Y, Yu J, Liu X, Zhang C, Cao J, Li G, Liu X, Chen Y, Huang H Tags: Biomed Pharmacother Source Type: research

Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPAR γ.
Nesfatin-1 promotes VSMC migration and neointimal hyperplasia by upregulating matrix metalloproteinases and downregulating PPARγ. Biomed Pharmacother. 2018 Mar 28;102:711-717 Authors: Zhang JR, Lu QB, Feng WB, Wang HP, Tang ZH, Cheng H, Du Q, Wang YB, Li KX, Sun HJ Abstract The dedifferentiation, proliferation and migration of vascular smooth muscle cells (VSMCs) are essential in the progression of hypertension, atherosclerosis and intimal hyperplasia. Nesfatin-1 is a potential modulator in cardiovascular functions. However, the role of nesfatin-1 in VSMC biology has not been explored. The prese...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Zhang JR, Lu QB, Feng WB, Wang HP, Tang ZH, Cheng H, Du Q, Wang YB, Li KX, Sun HJ Tags: Biomed Pharmacother Source Type: research

miR-566 functions as an oncogene and a potential biomarker for prognosis in renal cell carcinoma.
CONCLUSIONS: The results of the current study demonstrate that oncogene miR-566 is a potential biomarker not only for diagnosis but also for prognosis for RCC. PMID: 29604591 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Pan X, Quan J, Li Z, Zhao L, Zhou L, Jinling X, Weijie X, Guan X, Li H, Yang S, Gui Y, Lai Y Tags: Biomed Pharmacother Source Type: research

Quercus dilatata Lindl. ex Royle ameliorates BPA induced hepatotoxicity in Sprague Dawley rats.
In conclusion, the present study endorses the significant hepatoprotective potential of standardized extracts of Q. dilatata with known polyphenolics content and validates the traditional use of this plant in natural medicine to manage disorders like hepatotoxicity. PMID: 29604592 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Kazmi STB, Majid M, Maryam S, Rahat A, Ahmed M, Khan MR, Haq IU Tags: Biomed Pharmacother Source Type: research

Ebselen can Protect Male Reproductive Organs and Male Fertility from Manganese Toxicity: Structural and Bioanalytical Approach in a Rat Model.
Abstract Ebselen (EBS) is a versatile compound that can protect the cellular components from oxidative and free radical-mediated damage. In the present study, we investigated the protective effect of EBS against manganese (Mn) toxicity on male reproductive organs. Thirty-two male rats were assigned into four groups, namely, negative control, EBS (15 mg/kg body weight (bw), as a single protective IP injection), MnCl2 (50 mg/kg bw, orally for 30 consecutive days), and EBS + MnCl2 (as mentioned before). The results showed that EBS ameliorated the alterations caused by MnCl2 in the testicular, epididymal, an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Mohammed AT, Ebraheim LLM, Metwally MMM Tags: Biomed Pharmacother Source Type: research

LncRNA SNHG20 promotes cell proliferation and invasion via miR-140-5p-ADAM10 axis in cervical cancer.
CONCLUSIONS: Our study demonstrated that SNHG20 could function as an oncogenic lncRNA by regulating miR-140-5p-ADAM10 axis and MEK/ERK signaling pathway in cervical cancer. PMID: 29604594 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Guo H, Yang S, Li S, Yan M, Li L, Zhang H Tags: Biomed Pharmacother Source Type: research

Ameliorating effects of tempol on methotrexate-induced liver injury in rats.
Ouml;zcan O Abstract Methotrexate (MTX) is used in the treatment of certain types of cancers and chronic inflammatory illnesses, although the clinical use of MTX is limited due to its adverse effects, the most common of which are hepatotoxicity and nephrotoxicity. In the present study, we demonstrate the protecting influence of tempol related to oxidative stress in MTX-induced liver toxicity in rats using histopathological and biochemical parameters. The rats were divided into four groups: control group (group 1), tempol group (group 2), MTX group (group 3) and MTX + tempol group (group 4). The control group (...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Pınar N, Kaplan M, Özgür T, Özcan O Tags: Biomed Pharmacother Source Type: research

Submicron emulsion of cinnamaldehyde ameliorates bleomycin-induced idiopathic pulmonary fibrosis via inhibition of inflammation, oxidative stress and epithelial-mesenchymal transition.
CONCLUSIONS: Cinnamaldehyde ameliorated bleomycin-induced IPF via inhibition of inflammation and oxidative stress and EMT. PMID: 29604596 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Yan L, Song F, Li H, Li Y, Li J, He QY, Zhang D, Wang F, Zhang M, Zhao H, Feng T, Zhao YY, Wang SW Tags: Biomed Pharmacother Source Type: research

The natural phenolic peperobtusin A induces apoptosis of lymphoma U937 cells via the Caspase dependent and p38 MAPK signaling pathways.
Abstract Our previous research found the ethyl acetate extract of Peperomia tetraphylla (EAEPT) inhibited the growth of U937 cells by blocking the cell cycle and prompted apoptosis via the reactive oxygen species (ROS)-medicated mitochondria pathway. While the compounds in EAEPT which possessed the anti-tumor activity were unclear. Peperobtusin A is a phenolic compound, which was isolated from the whole plant of Peperomia tetraphylla. In this work, we found that peperobtusin A had the anti-proliferative effects against human lymphoma U937 cells and induced apoptosis in a dose dependent manner. Peperobtusin A signi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Shi L, Qin H, Jin X, Yang X, Lu X, Wang H, Wang R, Yu D, Feng B Tags: Biomed Pharmacother Source Type: research

Concentration-dependent dual effects of silibinin on kanamycin-induced cells death in Staphylococcus aureus.
Abstract Silibinin has dual effects on bacteria, depending on the concentrations or living contexts. The mechanism of either action has not yet been elucidated. Present study suggests that silibinin has yinyang impacts on the growth of Staphylococcus aureus depending on doses. S. aureus treated with low concentration of silibinin (L, 6.2 μM) showed enhanced resistance to kanamycin through increased level of hydrogen peroxide (H2O2). However, S. aureus treated with medium concentration of silibinin (M, 50 μM) showed increased susceptibility to kanamycin through reduced level of H2O2. These findings sugges...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Cai JY, Li J, Hou YN, Ma K, Yao GD, Liu WW, Hayashi T, Itoh K, Tashiro SI, Onodera S, Ikejima T Tags: Biomed Pharmacother Source Type: research

Garlic extract favorably modifies markers of endothelial function in obese patients -randomized double blind placebo-controlled nutritional intervention.
Abstract OBJECTIVE: Garlic exerts a range of effects relevant to human health. However, its influence on the endothelium in obese individuals remains unknown. We aimed to determine the effects of garlic extract (GE) on arterial stiffness and markers of endothelial function. METHODS: Ninety-two subjects were enrolled in this study. The participants were randomly assigned to receive 400 mg of GE or placebo daily for 3 months. The arterial stiffness index (SI) and markers of endothelial function such as high-sensitivity C-reactive protein (hsCRP), cholesterol (total, LDL, HDL), triglycerides, and plasminogen a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2018 Category: Drugs & Pharmacology Authors: Szulińska M, Kręgielska-Narożna M, Świątek J, Styś P, Kuźnar-Kamińska B, Jakubowski H, Walkowiak J, Bogdański P Tags: Biomed Pharmacother Source Type: research

Overexpression of lncRNA DANCR positively affects progression of glioma via activating Wnt/ β-catenin signaling.
In conclusion, DANCR positively affected glioma progression via activating Wnt/β-catenin signaling pathway. PMID: 29602127 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Li J, Zhou L Tags: Biomed Pharmacother Source Type: research

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art.
Abstract Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone which mediates many cellular processes such as cell transformation, proliferation, and survival in normal and stress conditions. Hsp90 plays an important role in folding, maturation, stabilization and activation of Hsp90 client proteins which all contribute to the development, and proliferation of cancer as well as other inflammatory diseases. Functional inhibition of Hsp90 can have a massive effect on various oncogenic and inflammatory pathways, and will result in the degradation of their client proteins. This turns it into an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Mellatyar H, Talaei S, Pilehvar-Soltanahmadi Y, Barzegar A, Akbarzadeh A, Shahabi A, Barekati-Mowahed M, Zarghami N Tags: Biomed Pharmacother Source Type: research

Sanyang Xuedai enhances the radiosensitivity of human non-small cell lung cancer cells via increasing iNOS/NO production.
CONCLUSION: SYKT resensitized radioresistant NCI-H460R cells via increasing cell apoptosis and cell cycle arrest. This was due to an elevated NO level caused by accumulating iNOS and effects of SYKT on radiosensitization of NSCLC should be further investigated in clinical application. PMID: 29602129 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Wang L, Xia Y, Chen T, Zeng Y, Li L, Hou Y, Li W, Liu Z Tags: Biomed Pharmacother Source Type: research

The mechanisms involved in miR-9 regulated apoptosis in cervical cancer by targeting FOXO3.
In conclusion, our results suggest that the inhibition of miR-9 could induce apoptosis in cervical cancer by targeting FOXO3 and presented a potential molecular target for the treatment of cervical cancer patients. PMID: 29602130 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Zhang H, Zhang Z, Wang S, Zhang S, Bi J Tags: Biomed Pharmacother Source Type: research

Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction.
This study investigated whether cholecalciferol cholesterol emulsion (CCE), a precursor of 1,25(OH)2D3, has similar effects. The impact of CCE on renal fibrosis and AQP2 and AQP4 expression were studied in a unilateralureteral obstruction (UUO) mouse nephropathy model. CCE reduced both the extent of fibrosis and transforming growth factor (TGF)-β signaling compared with vehicle-treated UUO model controls. AQP2 protein expression was higher and AQP4 expression was lower in UUO-model mice treated with CCE than in vehicle-treated control mice. The results showed that CCE attenuated renal fibrosis by inhibiting TGF-β...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Liu N, Zhang Y, Su H, Wang J, Liu Z, Kong J Tags: Biomed Pharmacother Source Type: research

Increased expression of circRNA_102231 in lung cancer and its clinical significance.
In conclusion, our study demonstrated that circRNA_102231 could act as a potential biomarker and therapeutic target for lung cancer patients. PMID: 29602132 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Zong L, Sun Q, Zhang H, Chen Z, Deng Y, Li D, Zhang L Tags: Biomed Pharmacother Source Type: research

Penconazole alters redox status, cholinergic function and lung's histoarchitecture of adult rats: Reversal effect of vitamin E.
In conclusion, our study demonstrated that vitamin E, a natural antioxidant, was effective in alleviating penconazole-induced lung damage in Wistar rats. PMID: 29602133 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 27, 2018 Category: Drugs & Pharmacology Authors: Chaâbane M, Elwej A, Ghorbel I, Chelly S, Mnif H, Boudawara T, Ellouze Chaabouni S, Zeghal N, Soudani N Tags: Biomed Pharmacother Source Type: research

LDR reverses DDP resistance in ovarian cancer cells by affecting ERCC-1, Bcl-2, Survivin and Caspase-3 expressions.
CONCLUSIONS: LDR reversed DDP resistance in SKOV3/DDP cells possibly by suppressing ERCC1, Bcl-2, and Survivin expressions, and increasing Caspase-3 expression. PMID: 29597088 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Ju X, Yu H, Liang D, Jiang T, Liu Y, Chen L, Dong Q, Liu X Tags: Biomed Pharmacother Source Type: research

Evaluation of curcumin loaded chitosan/PEG blended PLGA nanoparticles for effective treatment of pancreatic cancer.
Abstract Pancreatic cancer is considered as one of the most lethal type of cancer with a poor 5-year survival rate. Cancer metastasis represents one of the primary cause which limits therapy against this disease. Current chemotherapeutic approaches are largely ineffective, thus calling for the development of alternative strategies to combat this disease. In this regard, numerous studies have reported the anticancer effect of curcumin in different types of cancer including pancreatic cancer. However, low aqueous solubility, poor stability and decreased bioavailability associated with native curcumin holds back its ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Arya G, Das M, Sahoo SK Tags: Biomed Pharmacother Source Type: research

Lobaplatin promotes radiosensitivity, induces apoptosis, attenuates cancer stemness and inhibits proliferation through PI3K/AKT pathway in esophageal squamous cell carcinoma.
Abstract Radiotherapy is one of the common treatments for esophageal squamous cell carcinoma (ESCC). Yet, local recurrence led by radioresistance is still not solved. Lobaplatin (LBP) is known to have powerful clinical anti-tumor activities in various tumors, but its effect in radiotherapy is rarely studied. Here we report that LBP is a promising radiosensitizer for ESCC. We treated ESCC cells with LBP and radiation, both separately and in combination. Untreated cells were set as control groups. We found that LBP inhibited ESCC cell growth and enhanced their radiosensitivity. LBP also impeded the tumor growth in v...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Pan S, Sun Y, Sui D, Yang T, Fu S, Wang J, Hui B, Xi R, He C, Zhang X Tags: Biomed Pharmacother Source Type: research

A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L.
Abstract Hibiscus sabdariffa L. (roselle) belonging to the Malvaceae family is widely grown in many countries. This plant is often used in the traditional medicine being rich in phytochemicals like polyphenols especially anthocyanins, polysaccharides and organic acids thus having enormous prospective in modern therapeutic uses. The study aimed to review and document all the available evidence and information about the calyces of Hibiscus sabdariffa (roselle) with the special focus on their nutritional composition, bioactive constituents and therapeutic uses. The electronic database was searched up to 2017, using k...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Riaz G, Chopra R Tags: Biomed Pharmacother Source Type: research

Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents.
This study aims to explore the roles and related mechanisms of HuR in osteosarcoma (OS) cells migration, invasion, stemness and chemotherapeutical sensitivity. Here, we found that HuR exhibited higher level in OS tissues compared with the adjacent normal tissues. Knockdown of HuR with lentivirus infection suppressed OS cells migration and invasion, and thus the epithelial-mesenchymal transition (EMT) process. Additionally, HuR knockdown inhibited OS cells stemness. Mechanistically, YAP was identified as a direct target of HuR in OS cells, and HuR knockdown decreased its expression. Moreover, YAP transcriptional activity wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Xu W, Chen C, Xu R, Li Y, Hu R, Li Z, Zhu X Tags: Biomed Pharmacother Source Type: research

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy.
Abstract Numerous antitumor therapies have been developed based on the differences in cells' metabolisms. Regarding the important role of arginine (Arg) in the regulation of multiple metabolic and signaling pathways, its deprivation has been proposed as a good strategy for tumor regression in tumors with defected Arg metabolic enzymes like argininosuccinate synthase 1 (ASS1). However, modulatory effect of Arg on various cancers is also a controversial issue. Therefore, this review article intends to address some of the challenges faced by Arg deprivation method as well as Arg administration for cancer therapy. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2018 Category: Drugs & Pharmacology Authors: Jahani M, Noroznezhad F, Mansouri K Tags: Biomed Pharmacother Source Type: research

Zingerone ameliorates cisplatin-induced ovarian and uterine toxicity via suppression of sex hormone imbalances, oxidative stress, inflammation and apoptosis in female wistar rats.
This study aimed to investigate the ameliorative effect of ZO on CP-induced ovarian and uterine toxicity in female rats. The rats were subjected to a prophylactic oral treatment of ZO (25 and 50 mg/kg body weight) for seven days to measure the protective effect against ovarian and uterine toxicity induced by a single (i.p.) of CP (7 mg/kg body weight) on the first day whereas the rats were sacrificed on the eighth day. The results showed that ZO decreased the serum FSH hormone level, increased the serum E2 hormone level, and also maintained the ovarian and uterine histological architecture and integrity. In addition, Z...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2018 Category: Drugs & Pharmacology Authors: Kaygusuzoglu E, Caglayan C, Kandemir FM, Yıldırım S, Kucukler S, Kılınc MA, Saglam YS Tags: Biomed Pharmacother Source Type: research

Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
Abstract Serine/Arginine-Rich Protein-Specific Kinase-2 (SRSF protein kinase-2, SRPK2) is up-regulated in multiple human tumors. However, the expression, function and clinical significance of SRPK2 in prostate cancer (PCa) has not yet been understood. We therefore aimed to determine the association of SRPK2 with tumor progression and metastasis in PCa patients in our present study. The expression of SRPK2 was detected by some public datasets and validated using a clinical tissue microarray (TMA) by immunohistochemistry. The association of SRPK2 expression with various clinicopathological characteristics of PCa pat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2018 Category: Drugs & Pharmacology Authors: Zhuo YJ, Liu ZZ, Wan S, Cai ZD, Xie JJ, Cai ZD, Song SD, Wan YP, Hua W, Zhong W, Wu CL Tags: Biomed Pharmacother Source Type: research

Tea polysaccharide inhibits RANKL-induced osteoclastogenesis in RAW264.7 cells and ameliorates ovariectomy-induced osteoporosis in rats.
CONCLUSION: TPS can inhibit receptor activator nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis in RAW264.7 cells and ameliorate ovariectomy-induced osteoporosis in rats. PMID: 29587240 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 24, 2018 Category: Drugs & Pharmacology Authors: Xu H, Yin D, Liu T, Chen F, Chen Y, Wang X, Sheng J Tags: Biomed Pharmacother Source Type: research

Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products.
Abstract Being the most versatile biopolymer, chitooligosaccharide/chitosan oligosaccharide (COS) has been extensively studied for a range of exceptional biological activities and potential developments of novel medical devices and systems in biomedical and pharmaceutical fields. While possessing intrinsic biocompatibility, mucoadhesiveness, and non-toxicity it gained more interests in the biomedical development of novel systems, devices, and pharmaceutical formulations. The bioactive relativity of chitosan and COS are of highly significant and thus explored in this paper while highlighting its multiple biological...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Phil L, Naveed M, Mohammad IS, Bo L, Bin D Tags: Biomed Pharmacother Source Type: research

LncRNA SNHG6 acts as a prognostic factor to regulate cell proliferation in glioma through targeting p21.
In this study, the high expression of SNHG6 was tested in both glioma tissues and glioma cells. The correlation between expression levels of SNHG6 and the overall survival of glioma patients was demonstrated by using Kaplan Meier method analysis. Next, gain of function assays revealed that overexpression of SNHG6 can promote the formation of malignant phenotype of 1800 cell. However, results of loss-of-function assays revealed that silenced SNHG6 exerted the inhibitory function on glioma cell growth. Flow cytometric analysis was performed in glioma cells to detect the anti-oncogenic effects of silenced SNHG6 on cell cycle ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Cai G, Zhu Q, Yuan L, Lan Q Tags: Biomed Pharmacother Source Type: research

Molecular basis of vascular damage caused by cigarette smoke exposure and a new approach to the treatment: Alpha-linolenic acid.
Abstract Exposure to cigarette smoke (CS) causes vessel damage and mechanism of this damage has not yet been clearly identified. Therefore, in this study we aimed to investigate whether vessel damage due to the CS exposure will be prevented by the alpha-linolenic acid (ALA) or not which has anti-inflammatory effect in mice. For this reason, mice were grouped as controls (with and without CS) and ALA (with and without CS). The CS application continued 5 days a week for two months. At the end of two months, the mice were killed by cervical dislocation and their blood and thoracic aortas were isolated. ALA Treatment ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Kaplan HM, Kuyucu Y, Polat S, Pazarci P, Yegani AA, Şingirik E, Ertuğ P Tags: Biomed Pharmacother Source Type: research

Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice.
In this study, we investigated the protective role of arctigenin in Concanavalin A (ConA)-induced acute hepatitis in mice. Arctigenin remarkably reduced the congestion and necroinflammation of livers, and improved hepatic function (ALT and AST) in ConA-induced acute hepatitis in vivo. The infiltration of CD4 T, NKT and macrophages into the livers was found to be reduced with arctigenin treatment. Arctigenin suppressed ConA-induced T lymphocyte proliferations that might have resulted from enhanced IL-10 production by macrophages and CD4 T cells. These results suggested that arctigenin could be a powerful drug candidate for ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Cheng X, Wang H, Yang J, Cheng Y, Wang D, Yang F, Li Y, Zhou D, Wang Y, Xue Z, Zhang L, Zhang Q, Yang L, Zhang R, Da Y Tags: Biomed Pharmacother Source Type: research

Punicalagin ameliorates the elevation of plasma homocysteine, amyloid- β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain.
In conclusion, punicalagin protected from methionine-induced HHcy and brain damage with an ability to repress apoptosis by modulating apoptotic mediators and maintaining DNA integrity in the brain of mice. PMID: 29579708 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: El-Missiry MA, ElKomy MA, Othman AI, AbouEl-Ezz AM Tags: Biomed Pharmacother Source Type: research

The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D4 receptor binding and toxicological assessment.
In conclusion, it is suggested LQFM018 (2) promotes cell death in K562 cells via necroptotic signaling, probably with involvement of dopamine D4 receptor. These findings open new perspectives in cancer therapy by use of necroptosis inducing agents as a strategy of reverse cancer cell chemoresistance. PMID: 29579709 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Costa FB, Cortez AP, de Ávila RI, de Carvalho FS, Andrade WM, da Cruz AF, Reis KB, Menegatti R, Lião LM, Romeiro LAS, Noël F, Fraga CAM, Barreiro EJ, Sanz G, Rodrigues MF, Vaz BG, Valadares MC Tags: Biomed Pharmacother Source Type: research

Bu-shen-zhu-yun decoction promotes synthesis and secretion of FSH β and LHβ in anterior pituitary cells in vitro.
Bu-shen-zhu-yun decoction promotes synthesis and secretion of FSHβ and LHβ in anterior pituitary cells in vitro. Biomed Pharmacother. 2018 Mar 23;102:494-501 Authors: Jiang X, Zhou H, Shi M, Zhou B, Liu B, Yuan Y, Shan J, Xu J, Xie T Abstract Luteal phase defects (LPD) are an important etiology of infertility which has increased in recent years. Studies have shown that bu-shen-zhu-yun decoction (BSZY-D) can lower the expression of estrogen receptor and progesterone receptor, in rats endometrium of embryonic implantation period, which upregulated by mifepristone, and improve uterine receptivi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Jiang X, Zhou H, Shi M, Zhou B, Liu B, Yuan Y, Shan J, Xu J, Xie T Tags: Biomed Pharmacother Source Type: research

Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
In this study, we demonstrated that osthole could inhibit the ESCC cell proliferation in dose- and time-dependent manner. Osthole treatment also induced G2/M phase arrest and apoptosis of ESCC cells. Furthermore, upon exposure to osthole, the expression of Cyclin B1, Cdc2, Bcl-2, PARP1 and Survivin was decreased, while the expression of BAX, cleaved PARP1, cleaved Caspase3 and cleaved Caspase9 was increased. In addition, osthole treatment elicited upregulation of PTEN and downregulation of PI3K and phosphorylated AKT (p-AKT). Taken together, our study demonstrates that osthole could suppress ESCC proliferation through indu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q Tags: Biomed Pharmacother Source Type: research

Ginkgetin ameliorates experimental atherosclerosis in rats.
Abstract Atherosclerosis is a common disease seriously detrimental to human health. Natural products are important sources of therapeutic candidates for atherosclerosis. We here evaluated the effects of ginkgetin on experimental atherosclerosis in rats and explored the underlying mechanisms. Atherosclerosis was induced by high-fat diet for 12 weeks combined with single intraperitoneal injection of vitamin D3 in rats. The atherosclerotic rats were then treated with ginkgetin at 25, 50 and 100 mg/kg/d or simvastatin at 2 mg/kg/d for 8 weeks. Blood and thoracic aortas were collected for analyses of histopathology...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2018 Category: Drugs & Pharmacology Authors: Lian N, Tong J, Li W, Wu J, Li Y Tags: Biomed Pharmacother Source Type: research

The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF- κB/IL-6/STAT3 signaling in hepatocellular carcinoma.
In this study, we generated a novel herbal formula NHE-06, a water-decocting extract from six natural herbals, Ficus carica, Taraxacum mongolicum, Angelica sinensis, Lonicera japonica, Pseudo-ginseng and Folium ginkgo. We investigated the anti-inflammatory properties of NHE-06 and its antitumor efficacy in hepatocellular carcinoma, a typical inflammation-related cancer. We found that NHE-06 effectively suppressed NF-κB/IL-6/STAT3 signaling and enhanced antitumor immunity both in vitro and in HCC-bearing mice. In a subcutaneous HCC mouse model, we found that NHE-06 possessed both preventive and therapeutic functions. ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2018 Category: Drugs & Pharmacology Authors: Lu X, Wo G, Li B, Xu C, Wu J, Jiang C, Wei J Tags: Biomed Pharmacother Source Type: research

VS-5584 as a PI3K/mTOR inhibitor enhances apoptotic effects of subtoxic dose arsenic trioxide via inhibition of NF- κB activity in B cell precursor-acute lymphoblastic leukemia.
VS-5584 as a PI3K/mTOR inhibitor enhances apoptotic effects of subtoxic dose arsenic trioxide via inhibition of NF-κB activity in B cell precursor-acute lymphoblastic leukemia. Biomed Pharmacother. 2018 Mar 22;102:428-437 Authors: Toosi B, Zaker F, Alikarami F, Kazemi A, Teremmahi Ardestanii M Abstract Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway as a survival signaling cascade is a prominent feature of cancers such as acute lymphoblastic leukemia (ALL). In patients with B-cell precursor-ALL (BCP-ALL), the high activity of the pathway correlates with the weak response to a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 22, 2018 Category: Drugs & Pharmacology Authors: Toosi B, Zaker F, Alikarami F, Kazemi A, Teremmahi Ardestanii M Tags: Biomed Pharmacother Source Type: research

Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium.
This study was designed to investigate anti-arrhythmic and anti-inflammatory potentials of the natural bioflavonoid, troxerutin (TXR) in myocardial ischemia/reperfusion (I/R) injury in diabetic rats. METHODS: Male Wistar rats were randomly divided into 4 groups (control, control + TXR [150 mg/kg, daily], diabetic, and diabetic + TXR). Type-1 diabetes was induced by an intraperitoneal injection of streptozotocin (50 mg/kg) and lasted for 10 weeks. After mounting on the Langendorff apparatus, isolated hearts in all groups received a normal Krebs-Henseleit solution for 20 min of stabilization period, follow...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 21, 2018 Category: Drugs & Pharmacology Authors: Najafi M, Noroozi E, Javadi A, Badalzadeh R Tags: Biomed Pharmacother Source Type: research