Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Phytochemical profiling of Blumea laciniata (Roxb.) DC. and its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's
Biomed Pharmacother. 2021 Jul 8;141:111859. doi: 10.1016/j.biopha.2021.111859. Online ahead of print.ABSTRACTBlumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: A M Swaraz Fariha Sultana Md Wasim Bari Khondoker Shahin Ahmed Mehedi Hasan Md Monirul Islam Mohammad Amirul Islam Mohammed A Satter Md Hemayet Hossain Md Shofiqul Islam Md Iqbal Khan Md Obayed Raihan Source Type: research

Calcium-activated chloride channel is involved in the onset of diarrhea triggered by EGFR tyrosine kinase inhibitor treatment in rats
In conclusion, secretory diarrhea induced by treatment with EGFR-TKIs might be partially mediated by the activation of CaCC. Therefore, blocking the CaCC could be a potential new treatment for EGFR-TKI-induced diarrhea.PMID:34246954 | DOI:10.1016/j.biopha.2021.111860 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Yumi Harada Hitomi Sekine Kunitsugu Kubota Daichi Sadatomi Seiichi Iizuka Naoki Fujitsuka Source Type: research

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization
This study was to explore the anti-lung-metastatic activities and mechanism of RYP extract by regulating macrophage polarization. The results showed that RYP can inhibit the viability and induce the apoptosis of TNBC cells. In in vitro experiments, RYP significantly inhibited the invasion and migration ability of TNBC cells promoted by M2, the subtype of macrophage which increased TNBC metastasis related genes. In in vivo experiments, RYP reduced the TNBC progression and lung metastasis. M2/M1 ration in the lung and M2 in the tumor was reduced by RYP, as well as M2 master regulator Stat6. Therefore, RYP extract may exhibit...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Rui Yang Ying Xie Qiong Li Yiyi Ye Youyang Shi Xiangdong Zhao Chunyu Wu Yiyun Xu Rui Wang Yang Zhang Xiaojuan Yang Xianghui Han Sheng Liu Source Type: research

GeGen QinLian decoction alleviate influenza virus infectious pneumonia through intestinal flora
In conclusion, our study shows that GQD can affect systemic immunity, at least in part, through the intestinal flora, thereby protect the mice against influenza virus infectious pneumonia.PMID:34246956 | DOI:10.1016/j.biopha.2021.111896 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 11, 2021 Category: Drugs & Pharmacology Authors: Li Deng Yucong Shi Pei Liu Sizhi Wu Yiwen Lv Huachong Xu Xiaoyin Chen Source Type: research

Modulation of peptidases by 2,4-diamine-quinazoline derivative induces cell death in the amitochondriate parasite Trichomonas vaginalis
In this study we showed that 2,4-diamine-quinazoline derivative compound (PH100) kills T. vaginalis. PH100 showed activity against fresh clinical and American Type Culture Collection (ATCC) T. vaginalis isolates with no cytotoxicity against cells (HMVI, 3T3-C1 and VERO) and erythrocytes. In addition, PH100 showed synergistic action with metronidazole, indicating that these compounds act by different mechanisms. When investigating the mechanism of action of PH100 to ATCC 30236, apoptosis-like characteristics were observed, such as phosphatidylserine exposure, membrane alterations, and modulation of gene expression and activ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Juliana In ês Weber Graziela Vargas Rigo D ébora Assumpção Rocha Isadora Serraglio Fortes Adriana Seixas Saulo Fernandes de Andrade Tiana Tasca Source Type: research

Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells
CONCLUSION: The greater activity of RCA ASMC CaCCs complicated with an enhanced Ca2+ mobilization from both [Ca2+]i release and [Ca2+]o influx plays a pivotal role in the distinctive hypercontractility of RCAs to acidosis. Translation of these findings to human beings may lead to a new conception in our understanding and treating cardiac complications in severe acidosis.PMID:34243598 | DOI:10.1016/j.biopha.2021.111615 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Pengmei Guo Yu Liu Xiaojia Xu Guijin Ma Xiaomin Hou Yanying Fan Mingsheng Zhang Source Type: research

Purine metabolite-based machine learning models for risk prediction, prognosis, and diagnosis of coronary artery disease
Biomed Pharmacother. 2021 Jul;139:111621. doi: 10.1016/j.biopha.2021.111621. Epub 2021 May 10.ABSTRACTAlterations in xanthine oxidase activity are known to be pathologically influential on coronary artery disease (CAD), but the association between purine-related blood metabolites and CAD has only been partially elucidated. We performed global metabolomics profiling and network analysis on blood samples from the Wonju and Pyeongchang (WP) cohort study (n = 2055) to elucidate the importance of purine related metabolites associated with potential CAD risk. Then, 5 selected serum metabolites were quantified from the WP cohort,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Sunhee Jung Eunyong Ahn Sang Baek Koh Sang-Hak Lee Geum-Sook Hwang Source Type: research

Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways
Biomed Pharmacother. 2021 Jul;139:111632. doi: 10.1016/j.biopha.2021.111632. Epub 2021 May 9.ABSTRACTP-glycoprotein, encoded by ATP-binding cassette transporters B1 gene (ABCB1), renders multidrug resistance (MDR) during cancer chemotherapy. Several synthetic small molecule inhibitors affect P-glycoprotein (P-gp) transport function in MDR tumor cells. However, inhibition of P-gp transport function adversely accumulates chemotherapeutic drugs in non-target normal tissues. Moreover, most small-molecule P-gp inhibitors failed in the clinical trials due to the low therapeutic window at the maximum tolerated dose. Therefore, do...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: M Ganesan G Kanimozhi B Pradhapsingh Haseeb A Khan Abdullah S Alhomida Aishah Ekhzaimy G R Brindha N Rajendra Prasad Source Type: research

Comparative evaluation of the protective effects of oral administration of auraptene and umbelliprenin against CFA-induced chronic inflammation with polyarthritis in rats
This study aimed to evaluate the anti-inflammatory effect of Auraptene (AUR) and Umbelliprenin (UMB) in a rat model of rheumatoid arthritis (RA) induced by using complete Freund's adjuvant (CFA). Paw swelling of adjuvant arthritis rats measured at various times after CFA injection. Over 15 days of RA induction, mediator/cytokine-mediated processes involved in managing the regulation and resolving RA's inflammation were also quantified with ELISA. Histopathological changes were also assessed under a microscope 15 days after the CFA injection. AUR at all doses and UMB administration only at a 16 mM /kg administration dose si...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Kobra Shirani Mehrdad Iranshahi Vahid Reza Askari Zahra Gholizadeh Armin Attaran Zadeh Majid Zeinali Faezeh Vahdati Hassani Zhila Taherzadeh Source Type: research

Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling
In this study, it was found that Aβ induced decreased cell viability, cell cycle arrest and apoptosis in BV-2 cells, which were ameliorated by THC. In vivo, THC administration rescued learning and memory, and reduced Aβ burden in the hippocampus of APP/PS1 mice. By proteomic analysis of the hippocampus of mice, 157 differentially expressed proteins were identified in APP/PS1 mice treated with THC (comparing with APP/PS1 mice), which also suggested that the effects of THC on the cell cycle and apoptosis were mostly related to the "Ras signaling pathway", etc. In APP/PS1 mice, the down-regulation of Gab2 ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Yu Xiao Ying Dai Li Li Fang Geng Yisha Xu Jinqiu Wang Shu Wang Junning Zhao Source Type: research

α-amyrin-loaded nanocapsules produce selective cytotoxic activity in leukemic cells
CONCLUSION: α-amyrin-loaded nanocapsules appear to be a promising nanoformulation that could be used against leukemia.PMID:34243603 | DOI:10.1016/j.biopha.2021.111656 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Serafim Florentino Neto Ariadna Lafourcade Prada Leonardo Domingo Rosales Achod Heron Fernandes Vieira Torquato Cau ê Santos Lima Edgar Julian Paredes-Gamero Maria Oneide Silva de Moraes Emerson Silva Lima Edgar Hernandez Sosa Tatiane Pereira de Souza Je Source Type: research

Role of microbiota-derived short-chain fatty acids in nervous system disorders
Biomed Pharmacother. 2021 Jul;139:111661. doi: 10.1016/j.biopha.2021.111661. Epub 2021 May 8.ABSTRACTDuring the past decade, accumulating evidence from the research highlights the suggested effects of bacterial communities of the human gut microbiota and their metabolites on health and disease. In this regard, microbiota-derived metabolites and their receptors, beyond the immune system, maintain metabolism homeostasis, which is essential to maintain the host's health by balancing the utilization and intake of nutrients. It has been shown that gut bacterial dysbiosis can cause pathology and altered bacterial metabolites' fo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Rasoul Mirzaei Behnaz Bouzari Seyed Reza Hosseini-Fard Maryam Mazaheri Yaghoub Ahmadyousefi Milad Abdi Saba Jalalifar Zahra Karimitabar Ali Teimoori Hossein Keyvani Farhad Zamani Rasoul Yousefimashouf Sajad Karampoor Source Type: research

Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism
In this study, a series of novel pyrazole ring-containing isolongifolanone derivatives was designed, synthesized, and their anti-proliferative activities in three cancer cell lines were evaluated. Among them, compound 3b exhibited strongest antiproliferative ability on MCF-7 cancer cells and induced the generation of intracellular ROS and mitochondrial depolarization. More importantly, compound 3b still maintained antitumor activity in MCF-7 3D culture systems. The study on molecular mechanism suggested that compound 3b induced apoptosis via activation of caspase-3 and PARP, also via decreasing of Bcl-2 and increasing of B...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Yunyun Wang Wei Shi Chenliang Wu Lin Wan Yuxun Zhao Chenglong Zhang Wen Gu Shifa Wang Source Type: research

Accurate quantitative determination of affinity and binding kinetics for tight binding inhibition of xanthine oxidase
Biomed Pharmacother. 2021 Jul;139:111664. doi: 10.1016/j.biopha.2021.111664. Epub 2021 May 13.ABSTRACTThe accurate quantitative determination of affinity and binding kinetics (BK) for tight binding inhibition is extraordinary important from both the continuous optimization of compounds, particularly in developing structure-activity relationships (SAR), and the prediction of in vivo target occupancy (TO). Due to the unique properties for tight binding inhibition that the inhibitors are characterized by the ultrahigh-affinity, relatively fast association to the target enzyme combined with extremely slow dissociation of the i...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Haiyang Yang Xueyan Li Gang Li Huating Huang Wenning Yang Xiaoquan Jiang Muli Sen Jingjing Liu Yang Liu Yanli Pan Guopeng Wang Source Type: research

Pharmacokinetics/pharmacometabolomics-pharmacodynamics reveals the synergistic mechanism of a multicomponent herbal formula, Baoyuan decoction against cardiac hypertrophy
This study provides a novel strategy for investigating the dynamic interaction between BYD and the biosystem, providing unique insight for disclosing the active components and synergistic mechanisms of BYD against CH, which also supplies a reference for other MCHF related research.PMID:34243607 | DOI:10.1016/j.biopha.2021.111665 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Zhiyong Du Yingyuan Lu Jiaxu Sun Kun Chang Mengqiu Lu Meng Fang Xiangrui Zeng Wenxin Zhang Jinyang Song Xiaoyu Guo Pengfei Tu Yong Jiang Source Type: research

The molecular mechanism of LRP1 in physiological vascular homeostasis and signal transduction pathways
Biomed Pharmacother. 2021 Jul;139:111667. doi: 10.1016/j.biopha.2021.111667. Epub 2021 May 7.ABSTRACTInteractions between vascular smooth muscle cells (VSMCs), endothelial cells (ECs), pericytes (PCs) and macrophages (MФ), the major components of blood vessels, play a crucial role in maintaining vascular structural and functional homeostasis. Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1), a transmembrane receptor protein belonging to the LDL receptor family, plays multifunctional roles in maintaining endocytosis, homeostasis, and signal transduction. Accumulating evidence suggests that LRP1 modulates vas...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Zhaohui He Gang Wang Jianbo Wu Zonghao Tang Mao Luo Source Type: research

Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats
Biomed Pharmacother. 2021 Jul;139:111669. doi: 10.1016/j.biopha.2021.111669. Epub 2021 May 7.ABSTRACTHigh-altitude pulmonary edema (HAPE) is a life-threatening disease occurs in hypobaric hypoxia (HH) environment, which could be treated by Dexamethasone, but might cause side-effects. Potentilla anserina L polysaccharide (PAP) holds promising physiological and pharmacological properties which could be beneficial for HAPE treatment. In our study, the anti-hypoxia effect of PAP was firstly investigated through anti-normobaric hypoxia test and anti-acute hypoxia test. Then we established a model of HAPE and measured the lung w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Jipeng Shi Zhao Liu Maoxing Li Jie Guo Lele Chen Ling Ding Xu Ding Tao Zhou Ji Zhang Source Type: research

Dihydrotanshinone I inhibits aortic valve interstitial cell calcification via the SMAD1/5/8/NF- κB/ERK pathway
CONCLUSION: DHI (10 μM) treatment can reverse the osteogenic phenotypic transition of PVICs induced by osteogenic medium, and the mechanism may be related to NF-κB、ERK 1/2 and Smad1/5/8 pathways.PMID:34243610 | DOI:10.1016/j.biopha.2021.111674 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2021 Category: Drugs & Pharmacology Authors: Yue Wang Yaguang Weng Xian Li Qin Huang Yi Xiang Xiaorong Li Qiong Shi Source Type: research