Recombinant human interleukin-1 receptor antagonist treatment protects rats from myocardial ischemia-reperfusion injury.
Abstract The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia-reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block IL-1 by competitive binding to the IL-1 receptor type I (IL-1RI) and thus may provide a cardioprotective effect. In the present investigation, we determined whether exogenous administration of recombinant human IL-1Ra (rhIL-1Ra) provides a protective role against myocardial I/R injury. Sprague-Dawley rats underwent surgical coronary artery ligation (or sham operation) by occlus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 11, 2018 Category: Drugs & Pharmacology Authors: Zhu J, Huang J, Dai D, Wang X, Gao J, Han W, Zhang R Tags: Biomed Pharmacother Source Type: research

MiR-23a-3p acts as an oncogene and potential prognostic biomarker by targeting PNRC2 in RCC.
CONCLUSIONS: Our results reveals that miR-23a-3p may not only serve as a new biomarker for prognosis but also serve as a new therapeutic strategy in the RCC treatment. PMID: 30551118 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 11, 2018 Category: Drugs & Pharmacology Authors: Quan J, Pan X, Li Y, Hu Y, Tao L, Li Z, Zhao L, Wang J, Li H, Lai Y, Zhou L, Lin C, Gui Y, Ye J, Zhang F, Lai Y Tags: Biomed Pharmacother Source Type: research

Anticancer effects of alloxanthoxyletin and fatty acids esters - In vitro study on cancer HTB-140 and A549 cells.
arz W Abstract Alloxanthoxyletin, a natural occurring pyranocoumarin isolated from a number of plant sources, such as family of Rutaceae, and its synthetic derivatives show cytotoxic and antitumor activities. In the present study new eleven esters of alloxanthoxyletin and fatty acids were synthesized and evaluated for their anticancer toxicity. The structures of the compounds were confirmed by Proton Nuclear Magnetic Resonance (1H NMR), Carbon-13 Nuclear Magnetic Resonance (13C NMR) and High Resolution Mass Spectrometry (HRMS) analyses. For all compounds 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 10, 2018 Category: Drugs & Pharmacology Authors: Jóźwiak M, Struga M, Roszkowski P, Filipek A, Nowicka G, Olejarz W Tags: Biomed Pharmacother Source Type: research

Insight into the role of TRAIL in liver diseases.
Abstract TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL has recently been suggested as a potential therapeutic target in hepatocellular carcinoma (HCC) because it promotes apoptosis in cancer cells. Furthermore, studies on the role of TRAIL in liver injury have reported that TRAIL plays an essential role in viral hepatitis, fatty liver diseases, etc. However, several contradictory and confounding effects of TRAIL in these liver diseases have n...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 10, 2018 Category: Drugs & Pharmacology Authors: Jiang W, Wu DB, Fu SY, Chen EQ, Tang H, Zhou TY Tags: Biomed Pharmacother Source Type: research

MiR-92b targets p57kip2 to modulate the resistance of hepatocellular carcinoma (HCC) to ionizing radiation (IR) -based radiotherapy.
Abstract Hepatocellular carcinoma (HCC) is one of the most common digestive system malignant tumors. Due to the resistance to radiotherapy, the prognosis in patients with HCC is poor. Based on previous studies and online tools prediction, we hypothesized that miR-92b, which was reported to promote HCC cell proliferation, might bind to p57kip2, a well-known tumor suppressor, to modulate the radioresistance of HCC to ionizing radiation (IR) -based radiotherapy. In the present study, a higher miR-92b expression in HCC tissues and cell lines was observed; a high miR-92b expression was correlated with poorer prognosis ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 10, 2018 Category: Drugs & Pharmacology Authors: Wang J, Zhao H, Yu J, Xu X, Liu W, Jing H, Li N, Tang Y, Li Y, Cai J, Jin J Tags: Biomed Pharmacother Source Type: research

Antidiarrheal activity of α-terpineol in mice.
Antidiarrheal activity of α-terpineol in mice. Biomed Pharmacother. 2018 Dec 08;110:631-640 Authors: Dos Santos Negreiros P, da Costa DS, da Silva VG, de Carvalho Lima IB, Nunes DB, de Melo Sousa FB, de Souza Lopes Araújo T, Medeiros JVR, Dos Santos RF, de Cássia Meneses Oliveira R Abstract Diarrhea is one of the leading causes of infant death in the world accounting for high child mortality rate. It is also present in different pathophysiologies related to several etiological agents. The aim of this study is to investigate the antidiarrheal effect of α -Terpineol (α-TP...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2018 Category: Drugs & Pharmacology Authors: Dos Santos Negreiros P, da Costa DS, da Silva VG, de Carvalho Lima IB, Nunes DB, de Melo Sousa FB, de Souza Lopes Araújo T, Medeiros JVR, Dos Santos RF, de Cássia Meneses Oliveira R Tags: Biomed Pharmacother Source Type: research

Kojic acid applications in cosmetic and pharmaceutical preparations.
Abstract Skin color disorders can be caused by various factors, such as excessive exposure to sunlight, aging and hormonal imbalance during pregnancy, or taking some medications. Kojic acid (KA) is a natural metabolite produced by fungi that has the ability to inhibit tyrosinase activity in synthesis of melanin. The major applications of KA and its derivatives in medicine are based on their biocompatibility, antimicrobial and antiviral, antitumor, antidiabetic, anticancer, anti-speck, anti-parasitic, and pesticidal and insecticidal properties. In addition, KA and its derivatives are used as anti-oxidant, anti-prol...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2018 Category: Drugs & Pharmacology Authors: Saeedi M, Eslamifar M, Khezri K Tags: Biomed Pharmacother Source Type: research

Recruitment of macrophages and bone marrow stem cells to regenerating liver promoted by sodium phthalhydrazide in mice.
Abstract Pharmacological interventions which could be hepatoprotective, depending on bioavailability, anti-inflammatory and macrophage-targeting potential of drugs, are still at early preclinical stages. Existing evidence from many animal models of liver injury, as well as from human data, indicate that pharmacological and/or phytochemical interventions have limited impact on liver recovery. Recent studies on stem cell therapies focused on different cell subsets involved in tissue repair, including monocytes/macrophages and bone marrow cells migrating to the injured liver. Partial hepatectomy (PH) resulted in a ra...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2018 Category: Drugs & Pharmacology Authors: Danilova IG, Yushkov BG, Kazakova IA, Belousova AV, Minin AS, Abidov MT Tags: Biomed Pharmacother Source Type: research

Dexamethasone induces osteoblast apoptosis through ROS-PI3K/AKT/GSK3 β signaling pathway.
CONCLUSION: Our research verified that Dex induced osteoblasts apoptosis by ROS-PI3K/AKT/GSK3β signaling pathway. PMID: 30537677 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2018 Category: Drugs & Pharmacology Authors: Deng S, Dai G, Chen S, Nie Z, Zhou J, Fang H, Peng H Tags: Biomed Pharmacother Source Type: research

Investigation of the diabetic effects of maternal high-glucose diet on rats.
CONCLUSION: This study has experimentally demonstrated that high daily intake of sugar in healthy pregnancies causes adverse effects on the mother and offspring. PMID: 30537678 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 8, 2018 Category: Drugs & Pharmacology Authors: Ozkan H, Topsakal S, Ozmen O Tags: Biomed Pharmacother Source Type: research

Phytochemicals: Current strategy to sensitize cancer cells to cisplatin.
Abstract Cisplatin-based chemotherapeutic regimens are the most frequently used adjuvant treatments for many types of cancer. However, the development of chemoresistance to cisplatin results in treatment failure. Despite the significant developments in understanding the mechanisms of cisplatin resistance, effective strategies to enhance the chemosensitivity of cisplatin are lacking. Phytochemicals are naturally occurring plant-based compounds that can augment the anti-cancer activity of cisplatin, with minimal side effects. Notably, some novel phytochemicals, such as curcumin, not only increase the efficacy of cis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Sun CY, Zhang QY, Zheng GJ, Feng B Tags: Biomed Pharmacother Source Type: research

MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma.
In this study, we showed that the overexpression of miR-let-7e or knockdown of high mobility group box 1 (HMGB1) inhibited cell migration and invasion. MiR-let-7e downregulates HMGB1 expression by directly targeting the HMGB1 3'-UTR. Furthermore, HMGB1 reintroduction reversed the anti-proliferation, anti-migration, and anti-invasion roles of miR-let-7e. miR-let-7e might function as a tumor suppressor in papillary thyroid carcinoma through HMGB1. Therefore, our study demonstrates that miR-let-7e plays an important role in papillary thyroid carcinoma progression and might represent a new potential therapeutic target for trea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Ding C, Yu H, Shi C, Shi T, Qin H, Cui Y Tags: Biomed Pharmacother Source Type: research

High fat diet exacerbates intestinal barrier dysfunction and changes gut microbiota in intestinal-specific ACF7 knockout mice.
Abstract Microtubule-actin cross-linking factor-1 (ACF7, or MACF1) regulates cytoskeletal focal adhesion dynamics and migration in various tissues. High fat diet (HFD) induces gut microbiota dysbiosis and metabolic disorders, and increases intestinal permeability and inflammatory response. Here we investigated the synergistic effects of intestinal ACF7 conditional knockout (ACF7 cKO) and HFD on metabolism phenotypes, gut microbiota and intestinal barrier function in mice. ACF7 cKO and control (ACF7fl/fl) mice (8-week-old) were fed with either chow diet or HFD, for 16 weeks. The increase of body weight and fat pad ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Shi C, Li H, Qu X, Huang L, Kong C, Qin H, Sun Z, Yan X Tags: Biomed Pharmacother Source Type: research

Salvianolic acid B attenuates experimental skin fibrosis of systemic sclerosis.
Abstract Systemic sclerosis (SSc) is a connective tissue disease characterized mainly by fibrosis of skin and internal organs. Our previous study has shown that salvianolic acid B (SAB), a bioactive component extracted from Salvia miltiorrhiza (SM), was one of the essential ingredients in the traditional Chinese medicine Yiqihuoxue formula, which has been used to treat SSc-related dermal and pulmonary fibrosis. The aim of the present study was to evaluate the effect of SAB on skin fibrosis and explore its underlying anti-fibrotic mechanism. We found that SAB was capable of alleviating skin fibrosis in a bleomycin-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Liu Q, Lu J, Lin J, Tang Y, Pu W, Shi X, Jiang S, Liu J, Ma Y, Li Y, Xu J, Jin L, Wang J, Wu W Tags: Biomed Pharmacother Source Type: research

Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF- α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels.
Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-α, NF-ĸB, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother. 2018 Dec 07;110:554-560 Authors: Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N Abstract Oxyresveratrol, an active ingredient of Artocarpus lakoocha, is known to possess anti-inflammatory and immunomodulatory properties. Current study investigates the immunomodulatory effect of oxyresveratrol in mouse model of ethanol-induced ulcer. Anti-ulcer effect was determined using histopathological evaluation (H&E staining) an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N Tags: Biomed Pharmacother Source Type: research

Protective effects of Astragalin on spermatogenesis in streptozotocin-induced diabetes in male mice by improving antioxidant activity and inhibiting inflammation.
In conclusion, AG is a potential beneficial agent to protect diabetic-induced spermatogenic dysfunction in male mice by increasing antioxidant enzymes activities and inhibiting inflammation. PMID: 30537673 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Han XX, Jiang YP, Liu N, Wu J, Yang JM, Li YX, Sun M, Sun T, Zheng P, Jian-Qiang Yu Tags: Biomed Pharmacother Source Type: research

Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway.
CONCLUSIONS: Our data reveal the promising role of Leonurine hydrochloride in the prevention and treatment of NASH, in vitro and in vivo. This effect may be partially mediated by the AMPK/SREBP1 pathway. These findings provide a novel therapeutic target for the clinical treatment of NASH. PMID: 30537674 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2018 Category: Drugs & Pharmacology Authors: Zhang L, Li HX, Pan WS, Khan FU, Qian C, Qi-Li FR, Xu X Tags: Biomed Pharmacother Source Type: research

PCAT-1: A pivotal oncogenic long non-coding RNA in human cancers.
Abstract Prostate cancer-associated transcript 1 (PCAT-1) is a newly identified long non-coding RNA comprising two exons, located in the Chr8q24 gene desert approximately 725 kb upstream of the MYC oncogene. PCAT-1 is dysregulated and acts as an oncogene in different types of cancers and has been implicated in several processes correlated with carcinogenesis, such as cell proliferation, invasion, metastasis, apoptosis, cell cycle, chemoresistance, and homologous recombination. The mechanisms underlying the effects of PCAT-1 are complex and involve multiple factors and signaling pathways. In this paper, we systemat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2018 Category: Drugs & Pharmacology Authors: Yang Z, Zhao S, Zhou X, Zhao H, Jiang X Tags: Biomed Pharmacother Source Type: research

Raspberry ketone and Garcinia Cambogia rebalanced disrupted insulin resistance and leptin signaling in rats fed high fat fructose diet.
CONCLUSION: Our study highlights the involvement ofp-IRS-1/p-Akt/GLUT-4, leptin/STAT-3 and SREBP-1c signaling trajectories in the beneficial combination of GC and RK, besides, the efficient rebalance of the redox status, insulin resistance and tissue fat deposition confirmed histopathologically. PMID: 30530230 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2018 Category: Drugs & Pharmacology Authors: Attia RT, Abdel-Mottaleb Y, Abdallah DM, El-Abhar HS, El-Maraghy NN Tags: Biomed Pharmacother Source Type: research

Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities.
Corn silk (Zea mays L.), a source of natural antioxidants with α-amylase, α-glucosidase, advanced glycation and diabetic nephropathy inhibitory activities. Biomed Pharmacother. 2018 Dec 06;110:510-517 Authors: Wang KJ, Zhao JL Abstract The oxidative stress plays a critical role in the progression of diabetes mellitus (DM) and its complications. Corn silk is a traditional medicine used to treat DM. The aim of this study is to investigate the antioxidant capacity of corn silk, as well as its inhibitory potential on DM and diabetic nephropathy (DN). The ethanol extract of corn silk (CS) was l...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2018 Category: Drugs & Pharmacology Authors: Wang KJ, Zhao JL Tags: Biomed Pharmacother Source Type: research

The roles of ZEB1 in tumorigenic progression and epigenetic modifications.
Abstract Highly expressed Zinc-finger E-box binding protein 1 (ZEB1) is significantly associated with the malignancy of various cancers. Signal transduction and activation of ZEB1 play important roles in cancer transformation and epithelial-mesenchymal transition (EMT). Emerging evidence suggests that ZEB1 drives the induction of EMT with activation of stem cell traits, immune evasion and epigenetic reprogramming. As an ideal target for EMT research, ZEB1 has been extensively studied for decades. However, the link between ZEB1 and epigenetic regulation of EMT has only recently been discovered. ZEB1 facilitates the...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Zhang Y, Xu L, Li A, Han X Tags: Biomed Pharmacother Source Type: research

Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.
Abstract Sexual dysfunction in the epileptic patient is difficult to confirm whether it is ailment or therapy related. Antiepileptic drugs often use in reproductive age, through reproductive progress and maturation. On the other side, cold-pressed oils are rich in bioactive phytochemicals with health-promoting traits. The target of this work was to appraise the sexual dysfunction of antiepileptic Topiramate (TPM) and cold pressed ginger oil (CPGO) as antiepileptic alternative medicine in male mice. Fifty-four adult male albino mice were divided into nine groups (n = 6 mice). One group given saline an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: El Makawy AI, Ibrahim FM, Mabrouk DM, Ahmed KA, Fawzy Ramadan M Tags: Biomed Pharmacother Source Type: research

Wnt/ β-catenin signaling pathway contributes to isoflurane postconditioning against cerebral ischemia-reperfusion injury and is possibly related to the transforming growth factorβ1/Smad3 signaling pathway.
CONCLUSION: ISO postconditioning can reduce cerebral I/R injury by activating the Wnt/β-catenin signaling pathway and may be related to the TGF-β/Smad3 signaling pathway. PMID: 30530044 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Zhang G, Ge M, Han Z, Wang S, Yin J, Peng L, Xu F, Zhang Q, Dai Z, Xie L, Li Y, Si J, Ma K Tags: Biomed Pharmacother Source Type: research

SUR2B/Kir6.1 channel openers correct endothelial dysfunction in chronic heart failure via the miR-1-3p/ET-1 pathway.
In this study, we investigated the microRNAs (miRs) involved in the molecular mechanisms of SUR2B/Kir6.1 channel opening in chronic heart failure. Both iptakalim and natakalim significantly upregulated the expression of miR-1-3p, suggesting that this miR is closely associated with the therapeutic effects against chronic heart failure. Bioinformatic analysis showed that many of the 183 target genes of miR-1-3p are involved in cardiovascular diseases, suggesting that miR-1-3p plays a vital role in such diseases and vascular remodeling. Target gene prediction showed that miR-1-3p combines with the 3' untranslated region (UTR)...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Wang S, Guo X, Long CL, Li C, Zhang YF, Wang J, Wang H Tags: Biomed Pharmacother Source Type: research

Azithromycin treats diffuse panbronchiolitis by targeting T cells via inhibition of mTOR pathway.
Abstract Azithromycin (AZM), that is a macrolide antibiotic, has been found to treat diffuse panbronchiolitis (DPB) effectively. However, the mechanism of action underlying the therapeutic effects remains unclear. We selected 64 patients with DPB from 305 patients who were diagnosed with DPB at the outpatient clinic in Shanghai Pulmonary Hospital from Jan 2010 to Oct 2014. The primary PBLs, CD4 + T cells, and Jurkat T cells were treated with AZM or erythromycin (EM), and the effects of AZM and EM on IL-17A and CXCL-2 production, proliferation, apoptosis and autophagy were evaluated. AZM and EM signif...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Weng D, Wu Q, Chen XQ, Du YK, Chen T, Li H, Tang DL, Li QH, Zhang Y, Lu LQ, Zhou NY, Song JC, Wang C, Li HP Tags: Biomed Pharmacother Source Type: research

Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice.
In this study, the effects of BCLE on obese diabetes were investigated using the KK-Ay mice. The component F2 of BCLE alleviate hyperglycemia and insulin resistance, as indicated by decreased levels of FBG, AUC, GSP, LDH and insulin. High levels of hepatic G6Pase and PEPCK in KK-Ay mice were markedly attenuated by F2. The inhibitory effect of F2 on GSK-3β and the enhancement effect on liver glycogen demonstrated that F2 could significantly inhibit hepatic gluconeogenesis and glycogen accumulation. The higher PPAR γ showed F2 may prevent insulin resistance by PI3K signal transduction pathway. In addition, the com...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Guo Y, Dai R, Deng Y, Sun L, Meng S, Xin N Tags: Biomed Pharmacother Source Type: research

Dyslipidemia induced inflammatory status, platelet activation and endothelial dysfunction in rabbits: Protective role of 10-Dehydrogingerdione.
Abstract 10-Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein convertase subtilisin/kexin type 9 (PCSK9). Therefore, the present study aimed mainly to clarify the effect of 10-Dehydrogingerdione on cellular adhesion inflammatory molecules, platelet activation and endothelial dysfunction markers in addition to PCSK9 as compared to atorvastatin in dyslipidemic rabbits. Dyslipidemia was induced in 30 male rabbits, distributed in 3 equal groups through feeding dietary cholesterol (0.5% w...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: El-Seweidy MM, Sarhan Amin R, Husseini Atteia H, El-Zeiky RR, Al-Gabri NA Tags: Biomed Pharmacother Source Type: research

Expression of Mac-2 binding protein in human carotid atheroma is associated with plaque instability and clinical manifestations.
CONCLUSIONS: M2BP is highly expressed in advanced plaques and vulnerable regions and significantly correlated with clinical ischemic manifestations. Therefore, M2BP may serve as an important biomarker of plaque destabilization. PMID: 30530049 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Xie H, Chen L, Liu H, Cui Y, Cui L, Zhang P, Chen S Tags: Biomed Pharmacother Source Type: research

Therapeutic potential of targeting the Wnt/ β-catenin signaling pathway in colorectal cancer.
Therapeutic potential of targeting the Wnt/β-catenin signaling pathway in colorectal cancer. Biomed Pharmacother. 2018 Dec 05;110:473-481 Authors: Cheng X, Xu X, Chen D, Zhao F, Wang W Abstract Aberrant Wnt/β-catenin signaling has often been reported in different cancers, particularly colorectal cancer (CRC), and this signaling cascade is central to carcinogenesis. Approximately 80% of CRC cases harbor mutations in the adenomatous polyposis coli gene, and half of the remaining cases feature mutations in the β-catenin gene that affect the Wnt/β-catenin signaling pathway. Unsurprisin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Cheng X, Xu X, Chen D, Zhao F, Wang W Tags: Biomed Pharmacother Source Type: research

Neuroprotection and improvement of the histopathological and behavioral impairments in a murine Alzheimer's model treated with Zephyranthes carinata alkaloids.
Abstract In Alzheimer's disease (AD), amyloid beta (Aβ) plaques initiates a cascade of pathological events where the overactivation of N-methyl-d-aspartate receptors (NMDA) by excess glutamate (Glu) triggers oxidative processes that lead to the activation of microglial cells, inflammation, and finally neuronal death. Amaryllidaceae alkaloids exert neuroprotective activities against different neurotoxin-induced injuries in vitro, and although their biological potential is well demonstrated, their neuroprotective activity has not been reported in an in vivo model of AD. The aim of our study was to determine the...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2018 Category: Drugs & Pharmacology Authors: Cortes N, Sabogal-Guaqueta AM, Cardona-Gomez GP, Osorio E Tags: Biomed Pharmacother Source Type: research

Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro.
ito S, Simons SM Abstract Neovascularization, a process that includes vasculogenesis and angiogenesis, may be a physiological or pathologic event, but in any cases the phenomenon is related to the formation of vascular net and sprouting of endothelial cells from preexisting blood vessel. The tumor environment, which counts on the tumor cell proliferation, is plenty of proangiogenic factors, such as angiogenin, TGF (α and β), FGF, VEGF, all of them playing a crucial role in angiogenesis, an important hallmark of cancer frequently related to a poor prognosis. Therefore, therapies focusing the inhibition o...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2018 Category: Drugs & Pharmacology Authors: de Sá Junior PL, Dias Câmara DA, Sciani JM, Porcacchia AS, Moreira Fonseca PM, Mendonça RZ, Elifio-Esposito S, Simons SM Tags: Biomed Pharmacother Source Type: research

The effect of divalent metal cations on the αv integrin binding site is ligand and integrin specific.
In conclusion, this study demonstrates the need to determine the individual relationship between RGD ligands and the integrins they may engage in vivo, especially when determining selectivity profiles for potential RGD-mimetic small molecule therapeutics, with organ and disease state also considered. PMID: 30529769 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2018 Category: Drugs & Pharmacology Authors: Hall EH, Slack RJ Tags: Biomed Pharmacother Source Type: research

Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt/ β-catenin signaling pathway.
CONCLUSION: DCE suppressed liver cancer SMMC-7721 and BEL-7404 cells as well as primary liver cancer cells likely though activating mitochondria apoptosis pathway and inducing inhibition of Wnt/β-catenin pathway. PMID: 30529770 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2018 Category: Drugs & Pharmacology Authors: Guo Z, Zhou Y, Yang J, Shao X Tags: Biomed Pharmacother Source Type: research

Tropisetron inhibits sepsis by repressing hyper-inflammation and regulating the cardiac action potential in rat models.
The objective of the present investigation was to explore the possible effect of the 5-HT3 receptor antagonist tropisetron on the expression levels of the inflammatory factors interleukin 6 (IL-6), creatine kinase isoenzyme (CK-MB), soluble growth stimulating gene 2 protein (sST2) and immunoglobulin E (IgE), as well as the cardiac action potential in septic rats. METHODS: The cecal ligation and perforation (CLP) method was utilized to construct abdominal infarction in rats. A total of 68 male adult Sprague Dawley rats were used, including 40 for assessing survival and 28 for detecting the expression levels of IL-6 and...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2018 Category: Drugs & Pharmacology Authors: Liu Z, Zeng Z, Wu C, Liu H Tags: Biomed Pharmacother Source Type: research

Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats.
In conclusion; crocin demonstrated anti-ulcerogenic and coloprotective effect mediated primarily by its antioxidant, anti-inflammatory and anti-apoptotic properties. The therapeutic impact is mediated primarily via enhancement of colon Nrf2 content by 211% in protective protocol and by 350% in curative and HO-1 signaling by 49% in protective protocol and, 288% in the curative protocol. Enhancement of Nrf2 and HO-1 signaling and down-regulation of caspase-3 activity are believed to underly the observed therapeutic effect. PMID: 30530041 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biom...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2018 Category: Drugs & Pharmacology Authors: Khodir AE, Said E, Atif H, ElKashef HA, Salem HA Tags: Biomed Pharmacother Source Type: research

Nanosoldiers: A promising strategy to combat triple negative breast cancer.
Abstract The phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor prognosis. Conventional therapies employed in treatment of TNBC suffer from issues of poor bioavailability, poor cellular u...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Pawar A, Prabhu P Tags: Biomed Pharmacother Source Type: research

Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells.
CONCLUSION: PC-L-D demonstrated great potential for further development as an anticancer drug and could be the key to developing more effective and less toxic therapies against oral cancer. PMID: 30529767 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Macedo AL, da Silva DPD, Moreira DL, de Queiroz LN, Vasconcelos TRA, Araujo GF, Kaplan MAC, Pereira SSC, de Almeida ECP, Valverde AL, Robbs BK Tags: Biomed Pharmacother Source Type: research

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development.
CONCLUSIONS: WZ plays a protective role against MCD-induced steatohepatitis. The underlying mechanism likely involves the upregulation of PPAR-α/γ and downregulation of the NF-κB signalling pathway. Based on its beneficial effects on the liver, WZ is a promising therapeutic for NAFLD patients. PMID: 30522014 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Chen Z, Liu F, Zheng N, Guo M, Bao L, Zhan Y, Zhang M, Zhao Y, Guo W, Ding G Tags: Biomed Pharmacother Source Type: research

Long non-coding RNA SNHG6 enhances cell proliferation, migration and invasion by regulating miR-26a-5p/MAPK6 in breast cancer.
Abstract The long non-coding RNA (lncRNA) has recently been shown to be important regulators involved in the progression of various human cancers. Small nucleolar RNA host gene 6 (SNHG6) is a recently identified cancer-related lncRNA. However, the clinical significance and biological function of SNHG6 in breast cancer (BC) are still unclear. In the present study, we found that SNHG6 was highly expressed in BC tissues and cell lines, which was associated with poorer clinicopathologic features. Knockdown of SNHG6 inhibited BC cell proliferation, migration and invasion in vitro and in vivo using CCK-8, Edu staining, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Lv P, Qiu X, Gu Y, Yang X, Xu X, Yang Y Tags: Biomed Pharmacother Source Type: research

Er Shen Wan extract alleviates polyuria and regulates AQP 2 and AVPR 2 in a rat model of spleen-kidney Yang deficiency-induced diarrhea.
CONCLUSION: This study suggests that ESWP may elicit significant effects on the treatment of polyuria. Potential mechanisms at least partially involve hormone regulation, and alleviating renal pathological damage. Simultaneously, ESWP may alter renal water absorption by increasing AQP 2 and AVPR 2 expression levels. Thus, the in vivo experimental evidence indicates that ESWP has a therapeutic effect on the SKYD syndrome, which is consistent with its traditional usage. PMID: 30522016 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Xiong R, Li Y, Zheng K, Zhang T, Gao M, Li Y, Lian Y, Chen D, Hu C Tags: Biomed Pharmacother Source Type: research

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer.
We present a comprehensive knowledge of immune therapy through PD-1/PD-L1 blockade that argues how efficient the process is, in colon cancer carcinoma. In this review, we discuss the responsiveness of immunotherapy on PD-1/PD-L1 blockade and various tactics for overcoming weak responses to these checkpoint inhibitors in CRC. More research using controlled trials is required to enable new discoveries to provide continued success with immune-based therapies and grounds for optimism about the future of CRC patients. PMID: 30522017 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2018 Category: Drugs & Pharmacology Authors: Yaghoubi N, Soltani A, Ghazvini K, Hassanian SM, Hashemy SI Tags: Biomed Pharmacother Source Type: research

PSORI-CM02 alleviates IMQ-induced mouse dermatitis via differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3.
Abstract The IL-17-producing CD4+ T cell and γδT cells play critical roles in the pathogenesis of psoriasis (PS). PSORI-CM02 is a representative herbal formula for the treatment for PS in South China. It was confirmed to improve PS without obvious side effects in the clinic. Here we sought to clarify whether and how PSORI-CM02 regulates T cell differentiation and functions in IMQ-induced psoriasis-like BALB/c mouse model. Mice pre-treated 3 days with PSORI-CM02 significantly alleviated skin inflammation, as reduced in PASI score and classic psoriatic characteristics in pathological sections. CD3 and CD...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2018 Category: Drugs & Pharmacology Authors: Wu DH, Zhang MM, Li N, Li X, Cai QW, Yu WL, Liu LP, Zhu W, Lu CJ Tags: Biomed Pharmacother Source Type: research

Urinary proteome analysis of acute hypercoagulable state in rat model induced by ε-aminocaproic acid.
This study aimed to investigate systematic changes of urinary proteome in acute hypercoagulable state induced by certain antifibrinolytics. To reduce the effects of both genetic and environmental factors on the urinary proteome, we used a rat model of acute hypercoagulable state induced by an antifibrinolytic agent ε-aminocaproic acid, resembling human hypercoagulable state. Urine samples were collected during acute hypercoagulable state for analysis by liquid chromatography-tandem mass spectrometry (LCMS/MS). Of 65 significantly changed proteins in acute hypercoagulable state, 38 proteins had human orthologs, and ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2018 Category: Drugs & Pharmacology Authors: Jing J, Du Z, Ji S, Han K Tags: Biomed Pharmacother Source Type: research

Curcumin loading potentiates the neuroprotective efficacy of Fe3O4 magnetic nanoparticles in cerebellum cells of schizophrenic rats.
Abstract BACKGROUND: The aim of this study was to investigate the neurotoxic effects of Fe3O4 magnetic- CurNPs on isolated schizophrenia mitochondria of rats as an in vivo model. METHODS: We designed CMN loaded superparamagnetic iron oxide nanoparticles (SPIONs) (Fe3O4 magnetic- CurNPs) to achieve an enhanced therapeutic effect. The physicochemical properties of Fe3O4 magnetic- CurNPs were characterized using X-ray diffraction (XRD), and dynamic laser light scattering (DLS) and zeta potential. Further, to prove Fe3O4 magnetic- CurNPs results in superior therapeutic effects, and also, the mitochondrial membran...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2018 Category: Drugs & Pharmacology Authors: Naserzadeh P, Hafez AA, Abdorahim M, Abdollahifar MA, Shabani R, Peirovi H, Simchi A, Ashtari K Tags: Biomed Pharmacother Source Type: research

Human PBMCs fight or flight response to starvation stress: Increased T-reg, FOXP3, and TGF- β1 with decreased miR-21 and Constant miR-181c levels.
Human PBMCs fight or flight response to starvation stress: Increased T-reg, FOXP3, and TGF-β1 with decreased miR-21 and Constant miR-181c levels. Biomed Pharmacother. 2018 Dec;108:1404-1411 Authors: Rahmani M, Mohammadnia-Afrouzi M, Nouri HR, Fattahi S, Akhavan-Niaki H, Mostafazadeh A Abstract Regulatory T-lymphocytes play a prominent role in autoimmunity, allergy, and cancer. In some conditions such as inflammation and tumor, immune cells are encountered with metabolic stress. Emerging evidence indicates the contribution of microRNAs in both metabolism and immune regulation. Herewith, we have ex...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2018 Category: Drugs & Pharmacology Authors: Rahmani M, Mohammadnia-Afrouzi M, Nouri HR, Fattahi S, Akhavan-Niaki H, Mostafazadeh A Tags: Biomed Pharmacother Source Type: research

Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox.
In this study, we investigated the pharmacological mechanism of cyadox mediated by SZNF. Firstly, signaling pathways related to cyadox-induced SZNF expression were studied. The results showed that the mRNA level of SZNF reached the peak as early as 4 h after 2 μM cyadox treatment in swine hepatocytes. Several signaling pathways, including JAK2/STAT1, PI3K/Akt, TGF-β/Smad3 and p38, might play critical roles in regulation of SZNF. The JAK2/STAT1, JAK2/PI3K/Akt, PI3K/Akt and myD88 & TAK1 & ASK1 /P38 signaling pathways were firstly activated after cyadox treatment in swine hepatocyte, the T...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2018 Category: Drugs & Pharmacology Authors: Cui L, Xing D, Huang D, Li D, Lu Q, Wang X, Wang Y, Huang L, Cheng G, Hao H, Peng D, Liu Z, Dai M, Yuan Z Tags: Biomed Pharmacother Source Type: research

Experimental rodent models of chronic prostatitis and evaluation criteria.
This article reviews the recent advances in research on rodent models and analyzes the advantages, limitations, and evaluation criteria of various models for reference. PMID: 30453450 [PubMed - in process] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2018 Category: Drugs & Pharmacology Authors: Wang W, Naveed M, Baig MMFA, Abbas M, Xiaohui Z Tags: Biomed Pharmacother Source Type: research

Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by A β peptides in animal model of Alzheimer's disease.
Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by Aβ peptides in animal model of Alzheimer's disease. Biomed Pharmacother. 2018 Nov 18;110:47-58 Authors: Rahman SO, Panda BP, Parvez S, Kaundal M, Hussain S, Akhtar M, Najmi AK Abstract With the constant failure of the clinical trials continuous exploration of a therapeutic target against Alzheimer's disease (AD) is the utmost need. Numerous studies have supported the hypothesis that central insulin resistance plays a significant role in AD. Serine phosphorylation of Insulin Receptor Substarte-1 (IRS-1) has been found...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 18, 2018 Category: Drugs & Pharmacology Authors: Rahman SO, Panda BP, Parvez S, Kaundal M, Hussain S, Akhtar M, Najmi AK Tags: Biomed Pharmacother Source Type: research

Lycium barbarum polysaccharides protects H9c2 cells from hypoxia-induced injury by down-regulation of miR-122.
CONCLUSION: LBPs exhibited in vitro and in vivo cardioprotective activities via down-regulating miR-122. LBPs may have potential for the treatment of acute myocardial infarction (AMI). PMID: 30458344 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 17, 2018 Category: Drugs & Pharmacology Authors: Li Q, Zhang Z, Li H, Pan X, Chen S, Cui Z, Ma J, Zhou Z, Xing B Tags: Biomed Pharmacother Source Type: research

Synergistic inhibition of melanoma xenografts by Brequinar sodium and Doxorubicin.
Abstract Malignant melanoma continues to be a fatal disease for which novel and long-term curative breakthroughs are desired. One such innovative idea would be to assess combination therapeutic treatments - by way of combining two potentially effective and very different therapy. Previously, we have shown that DHODH inhibitors, A771726 and Brequinar sodium (BQR) induced cell growth impairment in melanoma cells. Similar results were seen with DHODH RNA interference (shRNA). In the present study, we showed that combination of BQR with doxorubicin resulted in synergistic and additive cell growth inhibition in these c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 17, 2018 Category: Drugs & Pharmacology Authors: Dorasamy MS, Ab A, Nellore K, Wong PF Tags: Biomed Pharmacother Source Type: research