Novel nitric oxide donors are coronary vasodilators that also bind to the papain-like protease of SARS-CoV-2
Biomed Pharmacother. 2024 Mar 15;173:116378. doi: 10.1016/j.biopha.2024.116378. Online ahead of print.ABSTRACTSeveral investigational nitric oxide donors were originally created to correct vascular endothelial dysfunction in cardiovascular diseases. These 48 compounds contain an urea-like moiety attached to the well-known NO donors isosorbide 2- and 5-mononitrate. CR-0305 and CR-0202 were synthesized and found to be nontoxic in the cell lines HMEC-1, A549/hACE2 and VeroE6. CR-0305 induced vasodilation in human coronary arteries ex vivo. Since NO can also have antiviral properties, a study of drug-protein interactions with ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 16, 2024 Category: Drugs & Pharmacology Authors: John F Schmedtje Fred Ciske Kendall M Muzzarelli Zahra Assar Source Type: research

Ferroptosis mechanisms and its novel potential therapeutic targets for DLBCL
Biomed Pharmacother. 2024 Mar 15;173:116386. doi: 10.1016/j.biopha.2024.116386. Online ahead of print.ABSTRACTDiffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses a significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with a typical cure rate of 50-70%. However, some patients either relapse after complete remission (CR) or exhibit resistance to R-CHOP treatment. Therefore, novel therapeutic approaches are imperative for managing high-risk or refractory DLBCL. Ferroptosis is...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 16, 2024 Category: Drugs & Pharmacology Authors: Wenxia Bian Haoran Li Yuhan Chen Yanhua Yu Guojie Lei Xinyi Yang Sainan Li Xi Chen Huanjuan Li Jing Yang Chen Yang Yanchun Li Yi Zhou Source Type: research

Morphing cholinesterase inhibitor amiridine into multipotent drugs for the treatment of Alzheimer's disease
Biomed Pharmacother. 2024 Mar 15;173:116399. doi: 10.1016/j.biopha.2024.116399. Online ahead of print.ABSTRACTThe search for novel drugs to address the medical needs of Alzheimer's disease (AD) is an ongoing process relying on the discovery of disease-modifying agents. Given the complexity of the disease, such an aim can be pursued by developing so-called multi-target directed ligands (MTDLs) that will impact the disease pathophysiology more comprehensively. Herewith, we contemplated the therapeutic efficacy of an amiridine drug acting as a cholinesterase inhibitor by converting it into a novel class of novel MTDLs. Applyi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 16, 2024 Category: Drugs & Pharmacology Authors: Eva Mezeiova Lukas Prchal Martina Hrabinova Lubica Muckova Lenka Pulkrabkova Ondrej Soukup Anna Misiachna Jiri Janousek Jakub Fibigar Tomas Kucera Martin Horak Galina F Makhaeva Jan Korabecny Source Type: research

Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis
This study provides further evidence that CNS is a potential antidepressant, offering new avenues for the treatment of depression.PMID:38490155 | DOI:10.1016/j.biopha.2024.116425 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Yiwei Zhou Yuhan Huang Wei Ye Zijie Chen Zhengzhong Yuan Source Type: research

Small extracellular vesicles loaded with carboplatin effectively enhance the cytotoxicity of drug-resistant cells from Y79 cells-in vitro
This study demonstrates that sequential exposure to CPT generates DR clones of Y79 cells, which could serve as an appropriate model to evaluate the efficacy of drugs. The sEVs-CPT were highly effective in enhancing cytotoxicity in DR-Y79 cells, and appear to hold promise as a novel complimentary drug delivery system.PMID:38490156 | DOI:10.1016/j.biopha.2024.116403 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Jyothi Attem Revu V L Narayana Radhika Manukonda Swathi Kaliki Geeta K Vemuganti Source Type: research

Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review
Biomed Pharmacother. 2024 Mar 13;173:116429. doi: 10.1016/j.biopha.2024.116429. Online ahead of print.ABSTRACTFibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Zhi Chunzhen Ren Qianrong Li Huaqing Xi Dong Li Qilin Chen Xinfang Lv Xiang Gao Xue Wu Chunling Wang Bing Jiang Zhongnan Mao Hugang Jiang Kai Liu Xinke Zhao Yingdong Li Source Type: research

Painful diabetic neuropathy: The role of ion channels
Biomed Pharmacother. 2024 Mar 14;173:116417. doi: 10.1016/j.biopha.2024.116417. Online ahead of print.ABSTRACTPainful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Qi Wang Yifei Ye Linghui Yang Lifan Xiao Jin Liu Wensheng Zhang Guizhi Du Source Type: research

Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis
This study provides further evidence that CNS is a potential antidepressant, offering new avenues for the treatment of depression.PMID:38490155 | DOI:10.1016/j.biopha.2024.116425 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Yiwei Zhou Yuhan Huang Wei Ye Zijie Chen Zhengzhong Yuan Source Type: research

Small extracellular vesicles loaded with carboplatin effectively enhance the cytotoxicity of drug-resistant cells from Y79 cells-in vitro
This study demonstrates that sequential exposure to CPT generates DR clones of Y79 cells, which could serve as an appropriate model to evaluate the efficacy of drugs. The sEVs-CPT were highly effective in enhancing cytotoxicity in DR-Y79 cells, and appear to hold promise as a novel complimentary drug delivery system.PMID:38490156 | DOI:10.1016/j.biopha.2024.116403 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Jyothi Attem Revu V L Narayana Radhika Manukonda Swathi Kaliki Geeta K Vemuganti Source Type: research

Painful diabetic neuropathy: The role of ion channels
Biomed Pharmacother. 2024 Mar 14;173:116417. doi: 10.1016/j.biopha.2024.116417. Online ahead of print.ABSTRACTPainful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Qi Wang Yifei Ye Linghui Yang Lifan Xiao Jin Liu Wensheng Zhang Guizhi Du Source Type: research

Therapeutic potential of Angelica sinensis in addressing organ fibrosis: A comprehensive review
Biomed Pharmacother. 2024 Mar 13;173:116429. doi: 10.1016/j.biopha.2024.116429. Online ahead of print.ABSTRACTFibrosis-related diseases (FRD) include conditions like myocardial fibrosis, pulmonary fibrosis, hepatic fibrosis, renal fibrosis, and others. The impact of fibrosis can be severe, causing organ dysfunction, reduced functionality, and even organ failure, leading to significant health issues. Currently, there is a lack of effective modern anti-fibrosis drugs in clinical practice. However, Chinese medicine has a certain beneficial effect on the treatment of such diseases. Angelica sinensis, with its considerable medi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 15, 2024 Category: Drugs & Pharmacology Authors: Xiaodong Zhi Chunzhen Ren Qianrong Li Huaqing Xi Dong Li Qilin Chen Xinfang Lv Xiang Gao Xue Wu Chunling Wang Bing Jiang Zhongnan Mao Hugang Jiang Kai Liu Xinke Zhao Yingdong Li Source Type: research

HIF-1 α Mediates Immunosuppression and Chemoresistance in Colorectal Cancer by Inhibiting CXCL9, -10 and -11
Biomed Pharmacother. 2024 Mar 13;173:116427. doi: 10.1016/j.biopha.2024.116427. Online ahead of print.ABSTRACTUncertainty exists regarding the mechanisms by which hypoxia-inducible factors (HIFs) control CD8+T-cell migration into tumor microenvironments. Here, we found that HIF-1α knockdown or overexpression resulted in increased or decreased CXCL9, -10, and -11 expression in vitro, respectively. Gene Set Variation Analysis revealed that elevated HIF-1α levels correlated with a poor prognosis, severe pathological stage, and an absence of CD8+ T cells in the tumor microenvironment in colorectal cancer (CRC) patients. HIF-...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 14, 2024 Category: Drugs & Pharmacology Authors: Yixi Su Jiaqi Liu Yu Tian Haiyan Dong Mengchen Shi Jingdan Zhang Weiqian Li Qiang Huang Nanlin Xiang Chen Wang Jun Liu Lingyuan He Limei Hu Ann M Haberman Huanliang Liu Xiangling Yang Source Type: research

Tangshen formula targets the gut microbiota to treat non-alcoholic fatty liver disease in HFD mice: A 16S rRNA and non-targeted metabolomics analyses
CONCLUSION: TSF treats the NAFLD phenotype by remodeling the gut microbiota and improving metabolic profile, suggesting that TSF is a functional gut microbial and metabolic modulator for the treatment of NAFLD.PMID:38484559 | DOI:10.1016/j.biopha.2024.116405 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 14, 2024 Category: Drugs & Pharmacology Authors: Shaopeng Wang Xin Li Bo Zhang Yuxi Li Kexu Chen Huimin Qi Mengqi Gao Jin Rong Lin Liu Yuzhou Wan Xi Dong Meihua Yan Liang Ma Ping Li Tingting Zhao Source Type: research

A combined transcriptomics and proteomics approach to reveal the mechanism of AEE relieving hyperlipidemia in ApoE < sup > -/- < /sup > mice
In this study, the mechanism and potential key pathways of AEE on improving hyperlipidemia in mice were investigated through the transcriptome and proteome study of ApoE-/- mice liver and the verification study on high-fat HepG2 cells. The results showed that AEE significantly decreased the serum TC and LDL-C levels of hyperlipidemia ApoE-/- mice, and significantly increased the enzyme activity of CYP7A1. After AEE intervention, the results of mice liver transcriptome and proteome showed that differential genes and proteins were enriched in lipid metabolism-related pathways. The results of RT-qPCR showed that AEE significa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 14, 2024 Category: Drugs & Pharmacology Authors: Xiao-Rong Lu Qi Tao Zhe Qin Xi-Wang Liu Shi-Hong Li Li-Xia Bai Wen-Bo Ge Ya-Xian Liu Jian-Yong Li Ya-Jun Yang Source Type: research

Emerging role of N6-methyladenosine RNA modification in regulation of SARS-CoV-2 infection and virus-host interactions
Biomed Pharmacother. 2024 Mar 13;173:116231. doi: 10.1016/j.biopha.2024.116231. Online ahead of print.ABSTRACTSince December 2019, the infection caused by Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2) has posed an enormous threat to human health security worldwide. Constant mutation of viral genome and varying therapeutic responses of patients infected with this virus prompted efforts to uncover more novel regulators in the pathogenesis. The involvement of N6-methyladenosine, a modified form of RNA, plays a crucial role in viral replication, viral pathogenicity, and intricate signaling pathways connecte...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 14, 2024 Category: Drugs & Pharmacology Authors: Jiayi Liu Lingli Chen Xiongmin Guo Bingrong Zhao Juan Jiang Source Type: research