Abnormal cannabidiol ameliorates inflammation preserving pancreatic beta cells in mouse models of experimental type 1 diabetes and beta cell damage
Biomed Pharmacother. 2021 Dec 3:112361. doi: 10.1016/j.biopha.2021.112361. Online ahead of print.ABSTRACTThe atypical cannabinoid Abn-CBD improves the inflammatory status in preclinical models of several pathologies, including autoimmune diseases. However, its potential for modulating inflammation in autoimmune type 1 diabetes (T1D) is unknown. Herein we investigate whether Abn-CBD can modulate the inflammatory response during T1D onset using a mouse model of T1D (non-obese diabetic- (NOD)-mice) and of beta cell damage (streptozotocin (STZ)-injected mice). Six-week-old female NOD mice were treated with Abn-CBD (0.1-1 mg/kg...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2021 Category: Drugs & Pharmacology Authors: Isabel Gonz ález-Mariscal Macarena Pozo Morales Silvana Y Romero-Zerbo Vanesa Espinosa-Jimenez Alejandro Escamilla-S ánchez Lourdes S ánchez-Salido Nadia Cobo-Vuilleumier Benoit R Gauthier Francisco J Berm údez-Silva Source Type: research

Toxicological and pharmacological effects of pentacyclic triterpenes rich fraction obtained from the leaves of Mansoa hirsuta
Biomed Pharmacother. 2021 Dec 3:112478. doi: 10.1016/j.biopha.2021.112478. Online ahead of print.ABSTRACTMansoa hirsuta is a medicinal plant native to the Brazilian semi-arid region. This approach aimed to investigate the in vitro and in vivo toxicity and anti-inflammatory and analgesic actions of the M. hirsuta fraction (MHF). In vitro cell viability was assessed in 3T3 cells. In vivo, the acute toxicity test, a single dose of the MHF was administered. For the subchronic toxicity test, three doses of were administered for 30 days. Locomotion and motor coordination were assessed using open field and rota-rod. The anti-infl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2021 Category: Drugs & Pharmacology Authors: Joquebede Rodrigues Pereira Aldilane Gon çalves da Fonseca Luzia Leiros de Sena Fernandes Allanny Alves Furtado Val éria Costa da Silva Valdir Flor êncio da Veiga Júnior Ant ônio Euzébio Goulart Sant'Ana Cl áudia Nunes Oliveira Gerlane Coelho Berna Source Type: research

Animal models of diabetic microvascular complications: Relevance to clinical features
Biomed Pharmacother. 2021 Dec 3:112305. doi: 10.1016/j.biopha.2021.112305. Online ahead of print.ABSTRACTDiabetes has become more common in recent years worldwide, and this growth is projected to continue in the future. The primary concern with diabetes is developing various complications, which significantly contribute to the disease's mortality and morbidity. Over time, the condition progresses from the pre-diabetic to the diabetic stage and then to the development of complications. Years and enormous resources are required to evaluate pharmacological interventions to prevent or delay the progression of disease or compli...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 7, 2021 Category: Drugs & Pharmacology Authors: Randhir Singh Shah Asma Farooq Ashi Mannan Thakur Gurjeet Singh Agnieszka Najda Zawi ślak Grażyna Ghadeer M Albadrani Amany A Sayed Mohamed M Abdel-Daim Source Type: research

Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
Biomed Pharmacother. 2021 Dec 1:112375. doi: 10.1016/j.biopha.2021.112375. Online ahead of print.ABSTRACTBreast cancer (BC) is mostly observed in women and is responsible for huge mortality in women subjects globally. Due to the continued development of drug resistance and other contributing factors, the scientific community needs to look for new alternatives, and drug repurposing is one of the best opportunities. Here we light upon the drug repurposing with a major focus on breast cancer. BC is a division of cancer known as the leading cause of death of 2.3 million women globally, with 685,000 fatalities. This number is s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Jonaid Ahmad Malik Sakeel Ahmed Bisma Jan Onur Bender Turki Al Hagbani Aali Alqarni Sirajudheen Anwar Source Type: research

Translation inhibition and suppression of stress granules formation by cisplatin
Biomed Pharmacother. 2021 Dec 1;145:112382. doi: 10.1016/j.biopha.2021.112382. Online ahead of print.ABSTRACTPlatinum-based antineoplastic drugs, such as cisplatin, are commonly used to induce tumor cell death. Cisplatin is believed to induce apoptosis as a result of cisplatin-DNA adducts that inhibit DNA and RNA synthesis. Although idea that DNA damage underlines anti-proliferative effects of cisplatin is dominant in cancer research, there is a poor correlation between the degree of the cell sensitivity to cisplatin and the extent of DNA platination. Here, we examined possible effects of cisplatin on post-transcriptional ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Paulina Pietras Ana ïs Aulas Marta M Fay Marta Le śniczak-Staszak Mateusz Sowi ński Shawn M Lyons Witold Szaflarski Pavel Ivanov Source Type: research

Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF- κB
Biomed Pharmacother. 2021 Dec 1;145:112474. doi: 10.1016/j.biopha.2021.112474. Online ahead of print.ABSTRACTCristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. In the non-toxic concentration range (from 20 to 100 μM), cristacarpin supp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Su Jung Hwang Won Keun Oh Ho-Young Lee Hyo-Jong Lee Source Type: research

Identification of early diagnostic biomarkers via WGCNA in gastric cancer
CONCLUSION: The expression levels of ITGAX, CCL14, ADHFE1, and HOXB13 in GC tumor tissues are considerably greater than in adjacent normal tissues. Systems biology approaches identified that these genes could be possible GC marker genes, providing ideas for other experimental studies in the future.PMID:34864309 | DOI:10.1016/j.biopha.2021.112477 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Zohreh Rezaei Javad Ranjbaran Hossein Safarpour Samira Nomiri Fatemeh Salmani Elham Chamani Pegah Larki Oronzo Brunetti Nicola Silvestris Tahmine Tavakoli Source Type: research

Aspirin and Sulindac act via different mechanisms to inhibit store-operated calcium channel: Implications for colorectal cancer metastasis
In this study, we tested eight candidate NSAIDs in Ca2+ imaging experiments and found that Aspirin and Sulindac were the most effective at suppressing SOCE. Furthermore, time-lapse FRET imaging using TIRF microscopy and ground state depletion (GSD) super-resolution (SR) imaging revealed that SOC was inhibited by Aspirin and Sulindac via different mechanisms. Aspirin quickly interrupted the STIM1-Orai1 interaction, whereas Sulindac mainly suppressed STIM1 translocation. Additionally, Aspirin and Sulindac both inhibited metastasis-related endpoints in CRC cells. Both drugs were used throughout the study at doses that suppres...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Yu-Shiuan Wang Nai-Kuei Huang Yu-Chiao Lin Wei-Chiao Chang Wan-Chen Huang Source Type: research

Revealing the suppressive role of protein kinase C delta and p38 mitogen-activated protein kinase (MAPK)/NF- κB axis associates with lenvatinib-inhibited progression in hepatocellular carcinoma in vitro and in vivo
In conclusion, this study reveals that the suppression of PKC-δ, and the p38 MAPK/NF-κB axis is associated with the lenvatinib-inhibited progression of HCC in vitro and in vivo.PMID:34864311 | DOI:10.1016/j.biopha.2021.112437 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Ching-Hsuan Wu Fei-Ting Hsu Tsu-Lan Chao Yuan-Hao Lee Yu-Cheng Kuo Source Type: research

Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
Biomed Pharmacother. 2021 Dec 1;145:112343. doi: 10.1016/j.biopha.2021.112343. Online ahead of print.ABSTRACTAn increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barri...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Zhongci Hang Tong Lei Zehua Zeng Shanglin Cai Wangyu Bi Hongwu Du Source Type: research

Photodynamic therapy with the dual-mode association of IR780 to PEG-PLA nanocapsules and the effects on human breast cancer cells
Biomed Pharmacother. 2021 Dec 1;145:112464. doi: 10.1016/j.biopha.2021.112464. Online ahead of print.ABSTRACTIR780 is a near-infrared fluorescent dye, which can be applied as a photosensitizer in photodynamic (PDT) and photothermal (PTT) therapies and as a biodistribution tracer in imaging techniques. We investigated the growth and migration inhibition and mechanism of death of breast tumor cells, MCF-7 and MDA-MB-231, exposed to polymeric nanocapsules (NC) comprising IR780 covalently linked to the biodegradable polymer PLA (IR-PLA) and IR780 physically encapsulated (IR780-NC) in vitro. Both types of NC had mean diameters ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Marina Guimar ães Carvalho Machado Maria Alice de Oliveira Elisa Gomes Lanna Raoni Pais Siqueira Gwenaelle Pound-Lana Renata Tupinamb á Branquinho Vanessa Carla Furtado Mosqueira Source Type: research

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players
In conclusion, PCSK9 inhibition impairs systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions. PCSK9 blockade may constitute a new therapeutic approach to control the inflammatory state associated with FH, preventing further cardiovascular events in this cardiometabolic disorder.PMID:34864314 | DOI:10.1016/j.biopha.2021.112460 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Patrice Marques Elena Domingo Arantxa Rubio Sergio Martinez-Herv ás Juan F Ascaso Laura Piqueras Jos é T Real Maria-Jesus Sanz Source Type: research

Repurposing an atherosclerosis targeting peptide for tumor imaging
In conclusion, although the target for the sulfo-Cy5-CTHRSSVVC peptide remains to be identified, the Cy5-CTHRSSVVC peptide warrants further investigation as a tumor imaging agent.PMID:34864315 | DOI:10.1016/j.biopha.2021.112469 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Luciana Kovacs Ryan A Davis Tanushree Ganguly Roger Chammas Julie L Sutcliffe Source Type: research

Immunostimulatory properties of heat-resistant RNA in a decoction of Glycyrrhizae Radix
Biomed Pharmacother. 2021 Dec 2;145:112457. doi: 10.1016/j.biopha.2021.112457. Online ahead of print.ABSTRACTResearch on the bioactive components of herbal medicines have been conducted mainly on the secondary metabolites of herbal plants. Accordingly, limited information is available on primary metabolites (carbohydrates, amino acids, lipids, and nucleic acids) and their biological effects. Here, we focused on the heat-resistant RNA of a decoction of Glycyrrhizae Radix and showed its immunostimulatory effects. The RNA activated NF-κB/AP-1 and induced TNF-α production in murine macrophages. Further analysis rev...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Akiko Inujima Keiichi Koizumi Naotoshi Shibahara Source Type: research

Drugs repurposed: An advanced step towards the treatment of breast cancer and associated challenges
Biomed Pharmacother. 2021 Dec 1:112375. doi: 10.1016/j.biopha.2021.112375. Online ahead of print.ABSTRACTBreast cancer (BC) is mostly observed in women and is responsible for huge mortality in women subjects globally. Due to the continued development of drug resistance and other contributing factors, the scientific community needs to look for new alternatives, and drug repurposing is one of the best opportunities. Here we light upon the drug repurposing with a major focus on breast cancer. BC is a division of cancer known as the leading cause of death of 2.3 million women globally, with 685,000 fatalities. This number is s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Jonaid Ahmad Malik Sakeel Ahmed Bisma Jan Onur Bender Turki Al Hagbani Aali Alqarni Sirajudheen Anwar Source Type: research

Translation inhibition and suppression of stress granules formation by cisplatin
Biomed Pharmacother. 2021 Dec 1;145:112382. doi: 10.1016/j.biopha.2021.112382. Online ahead of print.ABSTRACTPlatinum-based antineoplastic drugs, such as cisplatin, are commonly used to induce tumor cell death. Cisplatin is believed to induce apoptosis as a result of cisplatin-DNA adducts that inhibit DNA and RNA synthesis. Although idea that DNA damage underlines anti-proliferative effects of cisplatin is dominant in cancer research, there is a poor correlation between the degree of the cell sensitivity to cisplatin and the extent of DNA platination. Here, we examined possible effects of cisplatin on post-transcriptional ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Paulina Pietras Ana ïs Aulas Marta M Fay Marta Le śniczak-Staszak Mateusz Sowi ński Shawn M Lyons Witold Szaflarski Pavel Ivanov Source Type: research

Preventive effects of cristacarpin on experimentally induced uveitis by targeting NF- κB
Biomed Pharmacother. 2021 Dec 1;145:112474. doi: 10.1016/j.biopha.2021.112474. Online ahead of print.ABSTRACTCristacarpin is a novel prenylated pterocarpan that reportedly exhibits broad anti-cancer activity by enhancing endoplasmic reticulum stress. However, whether and how cristacarpin affects in-flammatory processes remain largely unknown. In the present study, the anti-inflammatory effect of cristacarpin on lipopolysaccharide (LPS)-induced inflammation was investigated using zebrafish embryos, RAW 264.7 macrophages, and mouse uveitis models. In the non-toxic concentration range (from 20 to 100 μM), cristacarpin supp...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Su Jung Hwang Won Keun Oh Ho-Young Lee Hyo-Jong Lee Source Type: research

Identification of early diagnostic biomarkers via WGCNA in gastric cancer
CONCLUSION: The expression levels of ITGAX, CCL14, ADHFE1, and HOXB13 in GC tumor tissues are considerably greater than in adjacent normal tissues. Systems biology approaches identified that these genes could be possible GC marker genes, providing ideas for other experimental studies in the future.PMID:34864309 | DOI:10.1016/j.biopha.2021.112477 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Zohreh Rezaei Javad Ranjbaran Hossein Safarpour Samira Nomiri Fatemeh Salmani Elham Chamani Pegah Larki Oronzo Brunetti Nicola Silvestris Tahmine Tavakoli Source Type: research

Aspirin and Sulindac act via different mechanisms to inhibit store-operated calcium channel: Implications for colorectal cancer metastasis
In this study, we tested eight candidate NSAIDs in Ca2+ imaging experiments and found that Aspirin and Sulindac were the most effective at suppressing SOCE. Furthermore, time-lapse FRET imaging using TIRF microscopy and ground state depletion (GSD) super-resolution (SR) imaging revealed that SOC was inhibited by Aspirin and Sulindac via different mechanisms. Aspirin quickly interrupted the STIM1-Orai1 interaction, whereas Sulindac mainly suppressed STIM1 translocation. Additionally, Aspirin and Sulindac both inhibited metastasis-related endpoints in CRC cells. Both drugs were used throughout the study at doses that suppres...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Yu-Shiuan Wang Nai-Kuei Huang Yu-Chiao Lin Wei-Chiao Chang Wan-Chen Huang Source Type: research

Revealing the suppressive role of protein kinase C delta and p38 mitogen-activated protein kinase (MAPK)/NF- κB axis associates with lenvatinib-inhibited progression in hepatocellular carcinoma in vitro and in vivo
In conclusion, this study reveals that the suppression of PKC-δ, and the p38 MAPK/NF-κB axis is associated with the lenvatinib-inhibited progression of HCC in vitro and in vivo.PMID:34864311 | DOI:10.1016/j.biopha.2021.112437 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Ching-Hsuan Wu Fei-Ting Hsu Tsu-Lan Chao Yuan-Hao Lee Yu-Cheng Kuo Source Type: research

Composition of intestinal flora affects the risk relationship between Alzheimer's disease/Parkinson's disease and cancer
Biomed Pharmacother. 2021 Dec 1;145:112343. doi: 10.1016/j.biopha.2021.112343. Online ahead of print.ABSTRACTAn increasing number of epidemiological studies have shown that there is a significant inverse relationship between the onset of Alzheimer's disease/Parkinson's disease (AD/PD) and cancer, but the mechanism is still unclear. Considering that intestinal flora can connect them, we tried to explain this phenomenon from the intestinal flora. This review briefly introduced the relationship among AD/PD, cancer, and intestinal flora, studied metabolites or components of the intestinal flora and the role of intestinal barri...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Zhongci Hang Tong Lei Zehua Zeng Shanglin Cai Wangyu Bi Hongwu Du Source Type: research

Photodynamic therapy with the dual-mode association of IR780 to PEG-PLA nanocapsules and the effects on human breast cancer cells
Biomed Pharmacother. 2021 Dec 1;145:112464. doi: 10.1016/j.biopha.2021.112464. Online ahead of print.ABSTRACTIR780 is a near-infrared fluorescent dye, which can be applied as a photosensitizer in photodynamic (PDT) and photothermal (PTT) therapies and as a biodistribution tracer in imaging techniques. We investigated the growth and migration inhibition and mechanism of death of breast tumor cells, MCF-7 and MDA-MB-231, exposed to polymeric nanocapsules (NC) comprising IR780 covalently linked to the biodegradable polymer PLA (IR-PLA) and IR780 physically encapsulated (IR780-NC) in vitro. Both types of NC had mean diameters ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Marina Guimar ães Carvalho Machado Maria Alice de Oliveira Elisa Gomes Lanna Raoni Pais Siqueira Gwenaelle Pound-Lana Renata Tupinamb á Branquinho Vanessa Carla Furtado Mosqueira Source Type: research

Beneficial effects of PCSK9 inhibition with alirocumab in familial hypercholesterolemia involve modulation of new immune players
In conclusion, PCSK9 inhibition impairs systemic inflammation and endothelial dysfunction by constraining leukocyte-endothelium interactions. PCSK9 blockade may constitute a new therapeutic approach to control the inflammatory state associated with FH, preventing further cardiovascular events in this cardiometabolic disorder.PMID:34864314 | DOI:10.1016/j.biopha.2021.112460 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Patrice Marques Elena Domingo Arantxa Rubio Sergio Martinez-Herv ás Juan F Ascaso Laura Piqueras Jos é T Real Maria-Jesus Sanz Source Type: research

Repurposing an atherosclerosis targeting peptide for tumor imaging
In conclusion, although the target for the sulfo-Cy5-CTHRSSVVC peptide remains to be identified, the Cy5-CTHRSSVVC peptide warrants further investigation as a tumor imaging agent.PMID:34864315 | DOI:10.1016/j.biopha.2021.112469 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Luciana Kovacs Ryan A Davis Tanushree Ganguly Roger Chammas Julie L Sutcliffe Source Type: research

Immunostimulatory properties of heat-resistant RNA in a decoction of Glycyrrhizae Radix
Biomed Pharmacother. 2021 Dec 2;145:112457. doi: 10.1016/j.biopha.2021.112457. Online ahead of print.ABSTRACTResearch on the bioactive components of herbal medicines have been conducted mainly on the secondary metabolites of herbal plants. Accordingly, limited information is available on primary metabolites (carbohydrates, amino acids, lipids, and nucleic acids) and their biological effects. Here, we focused on the heat-resistant RNA of a decoction of Glycyrrhizae Radix and showed its immunostimulatory effects. The RNA activated NF-κB/AP-1 and induced TNF-α production in murine macrophages. Further analysis rev...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 5, 2021 Category: Drugs & Pharmacology Authors: Akiko Inujima Keiichi Koizumi Naotoshi Shibahara Source Type: research

Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study
Biomed Pharmacother. 2021 Nov 30:112370. doi: 10.1016/j.biopha.2021.112370. Online ahead of print.ABSTRACTAIMS: Besides suppressing anti-tumoral immune responses, tumor-intrinsic inhibitory immune checkpoints have been implicated in tumor development. Herein, we aimed to investigate the significance of tumor-intrinsic CD73, as an inhibitory immune checkpoint, in non-small cell lung cancer (NSCLC) development and propose a novel therapeutic approach.MAIN METHODS: We investigated the cell viability, chemosensitivity, apoptosis, migration, and the cell cycle of A-549 and NCI-H1299 following treatment with cisplatin and CD73-s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2021 Category: Drugs & Pharmacology Authors: Elham Baghbani Saeed Noorolyai Shima Rahmani Dariush Shanehbandi Mahdi Abdoli Shadbad Leili Aghebati-Maleki Ahad Mokhtarzadeh Oronzo Brunetti Rossella Fasano Nicola Silvestris Behzad Baradaran Source Type: research

Silencing tumor-intrinsic CD73 enhances the chemosensitivity of NSCLC and potentiates the anti-tumoral effects of cisplatin: An in vitro study
Biomed Pharmacother. 2021 Nov 30:112370. doi: 10.1016/j.biopha.2021.112370. Online ahead of print.ABSTRACTAIMS: Besides suppressing anti-tumoral immune responses, tumor-intrinsic inhibitory immune checkpoints have been implicated in tumor development. Herein, we aimed to investigate the significance of tumor-intrinsic CD73, as an inhibitory immune checkpoint, in non-small cell lung cancer (NSCLC) development and propose a novel therapeutic approach.MAIN METHODS: We investigated the cell viability, chemosensitivity, apoptosis, migration, and the cell cycle of A-549 and NCI-H1299 following treatment with cisplatin and CD73-s...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 4, 2021 Category: Drugs & Pharmacology Authors: Elham Baghbani Saeed Noorolyai Shima Rahmani Dariush Shanehbandi Mahdi Abdoli Shadbad Leili Aghebati-Maleki Ahad Mokhtarzadeh Oronzo Brunetti Rossella Fasano Nicola Silvestris Behzad Baradaran Source Type: research

Nanostructured systems increase the in vitro cytotoxic effect of bullfrog oil in human melanoma cells (A2058)
Biomed Pharmacother. 2021 Nov 30;145:112438. doi: 10.1016/j.biopha.2021.112438. Online ahead of print.ABSTRACTThe aim of this work was to investigate the in vitro cytotoxic effect of previously developed nanocapsules, nanoemulsion, and microemulsion based on bullfrog oil (BFO) against human melanoma cells (A2058). The nanosystems were produced as described in previous studies and characterized according to droplet/particle distribution and zeta potential. The biocompatibility was evaluated by the determination of the hemolytic potential against human erythrocytes. The cytotoxicity assessment was based on MTT and cell death...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2021 Category: Drugs & Pharmacology Authors: W N Oliveira E N Alencar H A O Rocha L Amaral-Machado E S T Egito Source Type: research

Membrane model as key tool in the study of glutathione-s-transferase mediated anticancer drug resistance
In this study, we employed Langmuir monolayers of a mixture of phospholipids and cholesterol (MIX) as models for tumor cell membranes and investigated their interaction with the anticancer drugs cisplatin (CDDP) and doxorubicin (DOX). We found that both DOX and CDDP expand and affect the elasticity of MIX monolayers, but these effects are hindered when glutathione-s-transferase (GST) and its cofactor glutathione (GSH) are incorporated. Changes are induced by DOX or CDDP on the polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) data for MIX/GST/GSH monolayers, thus denoting some degree of interact...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2021 Category: Drugs & Pharmacology Authors: Elsa M Mater ón Flavio M Shimizu Kevin Figueiredo Dos Santos Gustavo F Nascimento Vanan élia P N Geraldo Osvaldo N Oliveira Ronaldo C Faria Source Type: research

Advances in biomedical study of the myopia-related signaling pathways and mechanisms
Biomed Pharmacother. 2021 Nov 30;145:112472. doi: 10.1016/j.biopha.2021.112472. Online ahead of print.ABSTRACTMyopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2021 Category: Drugs & Pharmacology Authors: Jing Yang Xinli Ouyang Hong Fu Xinyu Hou Yan Liu Yongfang Xie Haiqun Yu Guohui Wang Source Type: research

Melatonin pre-treated bone marrow derived-mesenchymal stem cells prompt wound healing in rat models
Biomed Pharmacother. 2021 Nov 30;145:112473. doi: 10.1016/j.biopha.2021.112473. Online ahead of print.ABSTRACTBone marrow derived-mesenchymal stem cells (BMSCs)-based therapy is an outstanding candidate for cutaneous wound healing. Melatonin (MEL) has been reported for its anti-inflammatory as well as tissue regenerative properties. Existing work aimed to explore the potential healing power of BMSCs pre-treated with MEL in a skin wound model. Adult rats were allocated into control, PIO, BMSCs (1 × 105 cells), and MEL/BMSCs groups. On the 21 days post-wounding, tissues were sampled for analysis. The results demonstrat...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2021 Category: Drugs & Pharmacology Authors: Aljohra M Al-Otaibi Asma S Al-Gebaly Rafa Almeer Gadah Albasher Wedad S Al-Qahtani Ahmed E Abdel Moneim Source Type: research

Structural modulation of gut microbiota during alleviation of experimental passive Heymann nephritis in rats by a traditional Chinese herbal formula
CONCLUSIONS: The JQHF is an effective agent for the treatment of experimental PHN. The PHN-allevating effect of JQHF is associated with specific alternation of gut microbiota.PMID:34861636 | DOI:10.1016/j.biopha.2021.112475 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 3, 2021 Category: Drugs & Pharmacology Authors: Xin-Hui Wang Ya-Nan Yang Ying Liang Rui Lang Qin Zeng Lei Yan Ren-Huan Yu Chong-Ming Wu Source Type: research

The inhibitory role of benzo-dioxole-piperamide on the phosphorylation process as an NF-Kappa B silencer
Biomed Pharmacother. 2021 Nov 29;145:112471. doi: 10.1016/j.biopha.2021.112471. Online ahead of print.ABSTRACTNF-κB contributes to the biosynthesis of various chemokines, cytokines, and enzymes. It plays many crucial roles in the upstream neuroinflammatory pathways. Briefly, the inhibitory IkB subunit is cleaved and phosphorylated by the IKK-α/β enzyme. It leads to the activation and translocation of the NF-κB (p50/p65) complex into the nucleus. Subsequently, the activated NF-κB interacts with the genomic DNA and contributes to expressing various proinflammatory cytokines. In the present study,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 2, 2021 Category: Drugs & Pharmacology Authors: Sajad Shahbazi Tara Zakerali Source Type: research

The inhibitory role of benzo-dioxole-piperamide on the phosphorylation process as an NF-Kappa B silencer
Biomed Pharmacother. 2021 Nov 28;145:112471. doi: 10.1016/j.biopha.2021.112471. Online ahead of print.ABSTRACTNF-κB contributes to the biosynthesis of various chemokines, cytokines, and enzymes. It plays many crucial roles in the upstream neuroinflammatory pathways. Briefly, the inhibitory IkB subunit is cleaved and phosphorylated by the IKK-α/β enzyme. It leads to the activation and translocation of the NF-κB (p50/p65) complex into the nucleus. Subsequently, the activated NF-κB interacts with the genomic DNA and contributes to expressing various proinflammatory cytokines. In the present study,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 2, 2021 Category: Drugs & Pharmacology Authors: Sajad Shahbazi Tara Zakerali Source Type: research

The inhibitory role of benzo-dioxole-piperamide on the phosphorylation process as an NF-Kappa B silencer
Biomed Pharmacother. 2021 Nov 28;145:112471. doi: 10.1016/j.biopha.2021.112471. Online ahead of print.ABSTRACTNF-κB contributes to the biosynthesis of various chemokines, cytokines, and enzymes. It plays many crucial roles in the upstream neuroinflammatory pathways. Briefly, the inhibitory IkB subunit is cleaved and phosphorylated by the IKK-α/β enzyme. It leads to the activation and translocation of the NF-κB (p50/p65) complex into the nucleus. Subsequently, the activated NF-κB interacts with the genomic DNA and contributes to expressing various proinflammatory cytokines. In the present study,...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 2, 2021 Category: Drugs & Pharmacology Authors: Sajad Shahbazi Tara Zakerali Source Type: research

The impact of individual human cytochrome P450 enzymes on oxidative metabolism of anticancer drug lenvatinib
Biomed Pharmacother. 2021 Nov 26;145:112391. doi: 10.1016/j.biopha.2021.112391. Online ahead of print.ABSTRACTLenvatinib, a small molecule tyrosine kinase inhibitor (TKI), exhibits good inhibitory effect in several types of carcinomas. Specifically, it is the most effective TKI used for treatment of thyroid cancer. To extend pharmacokinetics data on this anticancer agent, we aimed to identify the metabolites of lenvatinib formed during in vitro incubation of lenvatinib with human hepatic microsomes or recombinant cytochromes P450 (CYPs) by using high performance liquid chromatography and mass spectrometry. The role of CYPs...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2021 Category: Drugs & Pharmacology Authors: Katar ína Vavrová Radek Indra Petr Pompach Zbyn ěk Heger Petr Hodek Source Type: research

Current status of intratumour microbiome in cancer and engineered exogenous microbiota as a promising therapeutic strategy
Biomed Pharmacother. 2021 Nov 27;145:112443. doi: 10.1016/j.biopha.2021.112443. Online ahead of print.ABSTRACTResearch on the relationship between microbiome and cancer has made significant progress in the past few decades. It is now known that the gut microbiome has multiple effects on tumour biology. However, the relationship between intratumoral bacteria and cancers remains unclear. Growing evidence suggests that intratumoral bacteria are important components of the microenvironment in several types of cancers. Furthermore, several studies have demonstrated that intratumoral bacteria may directly influence tumorigenesis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2021 Category: Drugs & Pharmacology Authors: Jiawen Chen Ting Li Jianhao Liang Qiqi Huang Jian-Dong Huang Yiquan Ke Haitao Sun Source Type: research

Gardenia jasminoides extract ameliorates DfE-induced atopic dermatitis in mice through restoration of barrier function and T-helper 2-mediated immune response
Biomed Pharmacother. 2021 Nov 26;145:112344. doi: 10.1016/j.biopha.2021.112344. Online ahead of print.ABSTRACTAtopic dermatitis (AD) leads to skin barrier abnormalities and immune dysfunction. As the topical steroids commonly used to treat AD have side effects from long-term use, research into safer treatments for AD is greatly needed. The medicinal herb Gardenia jasminoides improves AD symptoms via skin barrier activation and T helper 2-mediated immune response regulation. Crocin, a bioactive component within the extract, is dispensible for its restorative effects. As such, this work explored the effects of Gardenia jasmi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2021 Category: Drugs & Pharmacology Authors: Sun Haeng Park Seol Jang Ho Kyoung Kim Source Type: research

Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
This article will discuss the relationship between the dopaminergic system and the immune system. It will also review the use of DRs agonists or antagonists to treat chronic and acute inflammatory diseases and corresponding immunomodulatory mechanisms.PMID:34847478 | DOI:10.1016/j.biopha.2021.112458 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2021 Category: Drugs & Pharmacology Authors: Mingan Li Lin Zhou Xiaohui Sun Yunqi Yang Ce Zhang Tian Wang Fenghua Fu Source Type: research

Synthesis compound XCR-7a ameliorates LPS-induced inflammatory response by inhibiting the phosphorylation of c-Fos
Biomed Pharmacother. 2021 Nov 26;145:112468. doi: 10.1016/j.biopha.2021.112468. Online ahead of print.ABSTRACTInflammation is a biological process closely related to different kinds of diseases, such as cancer and metabolic diseases. Therefore, effective control of the occurrence and development of inflammation is of great significance for disease prevention and control. Recently, 2-substituted indoles have gradually become a research hotspot because of their stability and pharmacological activity. Here we synthesized a series of compound containing 2-substituted indoles and investigated XCR-7a's role in inflammatory respo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 30, 2021 Category: Drugs & Pharmacology Authors: Haimei Tang Prasanta Roy Qianqian Di Xingyu Ma Yue Xiao Zherui Wu Jiazheng Quan Jiajing Zhao Weilie Xiao Weilin Chen Source Type: research

Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study
CONCLUSION: As these beta glucans are well known food supplements with a track record for safety, larger multi-centric clinical studies are recommended to validate their use as an adjunct in the management of COVID-19 and the ensuing long COVID-19 syndrome.PMID:34840031 | PMC:PMC8463314 | DOI:10.1016/j.biopha.2021.112243 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Vaddi Suryaprakash Kosagi-Sharaf Rao Nobunao Ikewaki Tohru Sonoda Gary A Levy Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Samuel Jk Abraham Source Type: research

Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Biomed Pharmacother. 2021 Nov 26:112352. doi: 10.1016/j.biopha.2021.112352. Online ahead of print.ABSTRACTA growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens. The production of SCFAs depends on the metabolic activity of intestinal microflora and is also affected by dietary changes. SCFAs play important roles in maintaining colonic health as an energy source, as a regulator of gene expression and cell differentiation, and as an anti-inflammatory agent. Additionally, the regulated expre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Rasoul Mirzaei Elahe Dehkhodaie Behnaz Bouzari Mandana Rahimi Abolfazl Gholestani Seyed Reza Hosseini-Fard Hossein Keyvani Ali Teimoori Sajad Karampoor Source Type: research

Construction of a circRNA-miRNA-mRNA network revealed the potential mechanism of Buyang Huanwu Decoction in the treatment of cerebral ischemia
In this study, we integrated the circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) network of middle cerebral artery occlusion (MACO) rats treated with BHD.METHODS: SD rats were randomly divided into a control group, model group, model+BHD group (2.5, 5, 10 g/kg) and model+butylphthalide (NBP) group (54 mg/kg). The neurological functions of the rats were evaluated by a modified neurological severity scoring (mNSS) system. Pathological lesions were assessed by Nissl staining, and the effects of BHD on neurovascular unit (NVU) associated protein microtubule-associated protein 2 (MAP2), glial fibrillary acidic prot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Bowei Chen Jian Yi Yaqian Xu Piao Zheng Rongmei Tang Baiyan Liu Source Type: research

Gut microbiota of patients with type 2 diabetes and gastrointestinal intolerance to metformin differs in composition and functionality from tolerant patients
CONCLUSIONS: Gut microbiota of subjects with gastrointestinal intolerance depicted taxonomic and functional differences compared to tolerant patients, and this changed differently after metformin administration.PMID:34844104 | DOI:10.1016/j.biopha.2021.112448 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Cristina Ma D íaz-Perdigones Araceli Mu ñoz-Garach Mar ía Dolores Álvarez-Bermúdez Isabel Moreno-Indias Francisco J Tinahones Source Type: research

Methyl ferulic acid ameliorates alcohol-induced hepatic insulin resistance via miR-378b-mediated activation of PI3K-AKT pathway
The objective of study was to evaluate the influence of MFA on insulin sensitivity in ethanol-induced L-02 cells as well as alcohol-fed mice and illuminate the function of miR-378b-mediated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway in system. MFA was found to remarkably down-regulate miR-378b level and increase IR and p110α expressions. Furthermore, the effect of MFA on modulating miR-378b/PI3K-AKT pathway to enhance insulin sensitivity was corroborated by overexpressing and inhibiting miR-378b. Taken together, MFA exhibited a positive effect against ALD by attenuating the inhibition of miR-378b...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Yan Zhang Jun Lu Yu-Juan Zhong Cheng-Fang Yang Li Chen Dan Wu Meng-Wei Song Lin Shi Zu-Heng Ma Li Li Yong-Wen Li Source Type: research

Empagliflozin adjunct with metformin for the inhibition of hepatocellular carcinoma progression: Emerging approach for new application
Biomed Pharmacother. 2021 Nov 26;145:112455. doi: 10.1016/j.biopha.2021.112455. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is on the rise worldwide, and its incidence in diabetic patients is two to three times that of non-diabetics. Current therapeutic options fail to provide considerable survival benefits to patients with HCC. There is a strong possibility that the FDA-approved antidiabetic combination of empagliflozin and metformin could show complementary effects to control HCC progression. However, their multitarget effects have not yet been studied on HCC development. Therefore, the present study aim...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Amir Mohamed Abdelhamid Sameh Saber Mahmoud E Youssef Ahmed Gaafar Ahmed Gaafar Hanan Eissa Marwa A Abd-Eldayem Mohammed Alqarni Gaber El-Saber Batiha Ahmad J Obaidullah Mohamed Awad Shahien Eman El-Ahwany Noha A Amin Mohamed Ali Etman Mohamed M Y Kaddah Source Type: research

Metformin action over gut microbiota is related to weight and glycemic control in gestational diabetes mellitus: A randomized trial
CONCLUSION: Metformin in GDM affects the composition and metabolic profile of gut microbiota. These changes could mediate, at least in part, its clinical effects. Studies designed to assess how these changes influence metabolic control during and after pregnancy are necessary.PMID:34844107 | DOI:10.1016/j.biopha.2021.112465 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Mar ía Molina-Vega Mar ía J Picón-César Carolina Guti érrez-Repiso Andrea Fern ández-Valero Fuensanta Lima-Rubio Stella Gonz ález-Romero Isabel Moreno-Indias Francisco J Tinahones Source Type: research

Beneficial effects of novel aureobasidium pullulans strains produced beta-1,3-1,6 glucans on interleukin-6 and D-dimer levels in COVID-19 patients; results of a randomized multiple-arm pilot clinical study
CONCLUSION: As these beta glucans are well known food supplements with a track record for safety, larger multi-centric clinical studies are recommended to validate their use as an adjunct in the management of COVID-19 and the ensuing long COVID-19 syndrome.PMID:34840031 | DOI:10.1016/j.biopha.2021.112243 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Kadalraja Raghavan Vidyasagar Devaprasad Dedeepiya Vaddi Suryaprakash Kosagi-Sharaf Rao Nobunao Ikewaki Tohru Sonoda Gary A Levy Masaru Iwasaki Rajappa Senthilkumar Senthilkumar Preethy Samuel Jk Abraham Source Type: research

Dual role of microbiota-derived short-chain fatty acids on host and pathogen
Biomed Pharmacother. 2021 Nov 26:112352. doi: 10.1016/j.biopha.2021.112352. Online ahead of print.ABSTRACTA growing body of documents shows microbiota produce metabolites such as short-chain fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and bacterial pathogens. The production of SCFAs depends on the metabolic activity of intestinal microflora and is also affected by dietary changes. SCFAs play important roles in maintaining colonic health as an energy source, as a regulator of gene expression and cell differentiation, and as an anti-inflammatory agent. Additionally, the regulated expre...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Rasoul Mirzaei Elahe Dehkhodaie Behnaz Bouzari Mandana Rahimi Abolfazl Gholestani Seyed Reza Hosseini-Fard Hossein Keyvani Ali Teimoori Sajad Karampoor Source Type: research

Construction of a circRNA-miRNA-mRNA network revealed the potential mechanism of Buyang Huanwu Decoction in the treatment of cerebral ischemia
In this study, we integrated the circular RNA (circRNA)-microRNA (miRNA)-messenger RNA (mRNA) network of middle cerebral artery occlusion (MACO) rats treated with BHD.METHODS: SD rats were randomly divided into a control group, model group, model+BHD group (2.5, 5, 10 g/kg) and model+butylphthalide (NBP) group (54 mg/kg). The neurological functions of the rats were evaluated by a modified neurological severity scoring (mNSS) system. Pathological lesions were assessed by Nissl staining, and the effects of BHD on neurovascular unit (NVU) associated protein microtubule-associated protein 2 (MAP2), glial fibrillary acidic prot...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 29, 2021 Category: Drugs & Pharmacology Authors: Bowei Chen Jian Yi Yaqian Xu Piao Zheng Rongmei Tang Baiyan Liu Source Type: research