Randomised clinical trial: Efficacy and safety of Qing-Chang-Hua-Shi granules in a multicenter, randomized, and double-blind clinical trial of patients with moderately active ulcerative colitis
In conclusion, QCHS granules were superior to the placebo in introducing clinical remission and mucosal healing, as well as in relieving mucus/blood stool in patients with moderately active and 5-ASA-refractory UC.PMID:33857914 | DOI:10.1016/j.biopha.2021.111580 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 15, 2021 Category: Drugs & Pharmacology Authors: Hong Shen Shengsheng Zhang Wenxia Zhao Shunping Ren Xiao Ke Qinghua Gu Zhipeng Tang Jingri Xie Suning Chen Yan Chen Jiandong Zou Lu Zhang Zhaofeng Shen Kai Zheng Yajun Liu Peiqing Gu Jiafei Cheng Jingyi Hu Lei Zhu Source Type: research

Cevimeline-induced anti-inflammatory effect through upregulations of mucins in the ocular surface of a dry eye mouse model
This study aimed to investigate the effects of various concentrations of cevimelines (CVMs) and compare them with commercial drugs in a murine model of dry eye. The experimental mouse model used male and female NOD.B10.H2b mice over 12 weeks of age. Desiccation stress was performed at 30-40% ambient humidity, and subcutaneous injection of 0.5 mg/0.2 mL scopolamine hydrobromide was performed four times a day for 10 days. The efficacy of various concentrations of CVMs (seven experimental groups) was first evaluated, and then 2% CVM was compared with commercial drugs, such as cyclosporine A (CsA), diquafosol (DQS), and rebami...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 15, 2021 Category: Drugs & Pharmacology Authors: Chae Eun Kim Young Jin Kim Moon Won Hwang Young-Joon Park Jaewook Yang Source Type: research

Angiotensin II: A possible target for therapeutic intervention in COVID-19
Biomed Pharmacother. 2021 Apr 6;139:111564. doi: 10.1016/j.biopha.2021.111564. Online ahead of print.NO ABSTRACTPMID:33848772 | DOI:10.1016/j.biopha.2021.111564 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Mohammad Rafi Khezri Keyvan Yousefi Morteza Ghasemnejad-Berenji Source Type: research

Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways
This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hypertension. In deoxycorticosterone acetate-salt rats, SR-5, SR-8, SR-9, and SR-10 reduced blood pressure and normalized renal functions. In isolated rat aortic rings, SR-5, SR-8, SR-9, and SR-10 relaxed phenylephrine (PE) and K+-induced contractions. The vasodilator effect was end...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Nadeem Irshad Arif-Ullah Khan None Alamgeer Salah-Ud-Din Khan Muhammad Shahid Iqbal Source Type: research

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?
Biomed Pharmacother. 2021 Apr 6;139:111578. doi: 10.1016/j.biopha.2021.111578. Online ahead of print.ABSTRACTThe COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the inf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Douglas Dourado Danielle T Freire Daniel T Pereira Lucas Amaral-Machado Éverton N Alencar Andr é Luís Branco de Barros E S ócrates T Egito Source Type: research

Pharmacological and clinical application of heparin progress: An essential drug for modern medicine
This article comprehensively reviews the modern research progress of heparin compounds; discusses the structure, preparation, and adverse reactions of heparin; emphasizes the pharmacological activity and clinical application of heparin; reveals the possible mechanism of the therapeutic effect of heparin in related clinical applications; provides evidence support for the clinical application of heparin; and hints on the significance of exploring the wider application fields of heparin.PMID:33848775 | DOI:10.1016/j.biopha.2021.111561 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Min Qiu Shengjie Huang Chuanhong Luo Zhenfeng Wu Binzhu Liang Haozhou Huang Zhimin Ci Dingkun Zhang Li Han Junzhi Lin Source Type: research

Research progress and application opportunities of nanoparticle-protein corona complexes
Biomed Pharmacother. 2021 Apr 10;139:111541. doi: 10.1016/j.biopha.2021.111541. Online ahead of print.ABSTRACTNanoparticles (NPs) can be used to design for nanomedicines with different chemical surface properties owing to their size advantages and the capacity of specific delivery to targeted sites in organisms. The discovery of the presence of protein corona (PC) has changed our classical view of NPs, stimulating researchers to investigate the in vivo fate of NPs as they enter biological systems. Both NPs and PC have their specificity but complement each other, so they should be considered as a whole. The formation and ch...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Wei Huang Gao Xiao Yujuan Zhang Weiping Min Source Type: research

Angiotensin II: A possible target for therapeutic intervention in COVID-19
Biomed Pharmacother. 2021 Apr 6;139:111564. doi: 10.1016/j.biopha.2021.111564. Online ahead of print.NO ABSTRACTPMID:33848772 | DOI:10.1016/j.biopha.2021.111564 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Mohammad Rafi Khezri Keyvan Yousefi Morteza Ghasemnejad-Berenji Source Type: research

Antihypertensive potential of selected pyrimidine derivatives: Explanation of underlying mechanistic pathways
This study was designed to determine the effectiveness of 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9) and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hypertension. In deoxycorticosterone acetate-salt rats, SR-5, SR-8, SR-9, and SR-10 reduced blood pressure and normalized renal functions. In isolated rat aortic rings, SR-5, SR-8, SR-9, and SR-10 relaxed phenylephrine (PE) and K+-induced contractions. The vasodilator effect was end...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Nadeem Irshad Arif-Ullah Khan None Alamgeer Salah-Ud-Din Khan Muhammad Shahid Iqbal Source Type: research

Will curcumin nanosystems be the next promising antiviral alternatives in COVID-19 treatment trials?
Biomed Pharmacother. 2021 Apr 6;139:111578. doi: 10.1016/j.biopha.2021.111578. Online ahead of print.ABSTRACTThe COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the inf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Douglas Dourado Danielle T Freire Daniel T Pereira Lucas Amaral-Machado Éverton N Alencar Andr é Luís Branco de Barros E S ócrates T Egito Source Type: research

Pharmacological and clinical application of heparin progress: An essential drug for modern medicine
This article comprehensively reviews the modern research progress of heparin compounds; discusses the structure, preparation, and adverse reactions of heparin; emphasizes the pharmacological activity and clinical application of heparin; reveals the possible mechanism of the therapeutic effect of heparin in related clinical applications; provides evidence support for the clinical application of heparin; and hints on the significance of exploring the wider application fields of heparin.PMID:33848775 | DOI:10.1016/j.biopha.2021.111561 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Min Qiu Shengjie Huang Chuanhong Luo Zhenfeng Wu Binzhu Liang Haozhou Huang Zhimin Ci Dingkun Zhang Li Han Junzhi Lin Source Type: research

Research progress and application opportunities of nanoparticle-protein corona complexes
Biomed Pharmacother. 2021 Apr 10;139:111541. doi: 10.1016/j.biopha.2021.111541. Online ahead of print.ABSTRACTNanoparticles (NPs) can be used to design for nanomedicines with different chemical surface properties owing to their size advantages and the capacity of specific delivery to targeted sites in organisms. The discovery of the presence of protein corona (PC) has changed our classical view of NPs, stimulating researchers to investigate the in vivo fate of NPs as they enter biological systems. Both NPs and PC have their specificity but complement each other, so they should be considered as a whole. The formation and ch...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 13, 2021 Category: Drugs & Pharmacology Authors: Wei Huang Gao Xiao Yujuan Zhang Weiping Min Source Type: research

An update on the role of miR-379 in human disorders
Biomed Pharmacother. 2021 Apr 10;139:111553. doi: 10.1016/j.biopha.2021.111553. Online ahead of print.ABSTRACTmiR-379 is a miRNA transcribed from the MIR379 locus on 14q32.31. This miRNA is located in an evolutionarily conserved miRNA cluster in an imprinted region that contains DLK1 and DIO3 genes. The mouse homolog of this miRNA has been shown to be under-expressed in response to glucocorticoid receptor deficiency. Moreover, miR-379 has a tumor-suppressive role in a wide variety of tissues including the brain, breast, lung, and liver. In addition to restraining cell proliferation and migration, miR-379 can suppress the e...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Soudeh Ghafouri-Fard Donya Shaterabadi Afete Abak Hamed Shoorei Zahra Bahroudi Mohammad Taheri Seyed Ali Mousavinejad Source Type: research

Amyloid- β: A double agent in Alzheimer's disease?
Biomed Pharmacother. 2021 Apr 10;139:111575. doi: 10.1016/j.biopha.2021.111575. Online ahead of print.ABSTRACTAmyloid-β (Aβ) accumulation is one of the cardinal pathological hallmarks of Alzheimer's disease and plays an important role in its pathogenesis. Although the neurotoxic effects of Aβ has been extensively studied, recent studies have revealed that it may also have protective effects. Here, we review novel findings that have shifted our understanding of the role of Aβ in the pathogenesis of Alzheimer's disease. An in-depth and comprehensive understanding of Aβ will provide us with a broader ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Hao Yu Jie Wu Source Type: research

Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs
CONCLUSIONS: While we could not confirm or refute previously identified DDI signals, numerically elevated RRRs for serious bleeding with several clopidogrel + hypnotic pairs warrant further examination.PMID:33845372 | DOI:10.1016/j.biopha.2021.111559 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Thanh Phuong Pham Nguyen Colleen M Brensinger Warren B Bilker Sean Hennessy Charles E Leonard Source Type: research

Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up-regulation of atriopeptin
This study investigated the diuretic efficacy and underlying mechanism of a macroporous adsorption resin with 30% ethanol elution fraction from L. supina (LSC) in saline-loaded rats and to identify its phytochemicals by ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-qTOF-MS/MS). As a result, 18 phenylpropanoids, 14 flavonoids and 15 others were identified in LSC, among which stachysoside A and acteoside could be the main bio-active constituents responsible for the diuretic effect. In parallel, the daily administration of LSC (16, 32 and 64 mg/kg) markedly promoted uri...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Junwei He Li Yang Source Type: research

Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans
This study investigated the activity of Asiatic acid (AA) alone and in combination with fluconazole (FLC) against C. albicans in vitro and in vivo. The in vitro studies indicated that the drug combination had a synergistic effect on FLC-resistant C. albicans, with fractional inhibitory concentration index (FICI) of 0.25. And when AA at the dose of 32 µg/mL, the drug combination group could decrease the sessile minimum inhibitory concentration (sMIC) of FLC from> 1024 µg/mL to 0.125-0.25 µg/mL within 8 h against C. albicans biofilms, even with the FICI> 0.5. In vivo, the antifungal efficacy of AA use...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Yuting Wang Chunyan Lu Xia Zhao Decai Wang Yaxin Liu Shujuan Sun Source Type: research

Supplementation with ribonucleotide-based ingredient (Ribodiet ®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer
Biomed Pharmacother. 2021 Apr 10;139:111579. doi: 10.1016/j.biopha.2021.111579. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain. Additionally, increasing evidence demonstrates that a neuroinflammatory state and oxidative stress, iron-dependent, play a crucial role in the onset and disease progression. Besides conventional therapies, the use of natural-based products represents a future medical option for AD treatment and/or prevention. We, therefore, evaluated t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Anella Saviano Gian Marco Casillo Federica Raucci Alessia Pernice Cristina Santarcangelo Marialuisa Piccolo Maria Grazia Ferraro Miriam Ciccone Alessandro Sgherbini Nadia Pedretti Daniele Bonvicini Carlo Irace Maria Daglia Nicola Mascolo Francesco Maione Source Type: research

An update on the role of miR-379 in human disorders
Biomed Pharmacother. 2021 Apr 9;139:111553. doi: 10.1016/j.biopha.2021.111553. Online ahead of print.ABSTRACTmiR-379 is a miRNA transcribed from the MIR379 locus on 14q32.31. This miRNA is located in an evolutionarily conserved miRNA cluster in an imprinted region that contains DLK1 and DIO3 genes. The mouse homolog of this miRNA has been shown to be under-expressed in response to glucocorticoid receptor deficiency. Moreover, miR-379 has a tumor-suppressive role in a wide variety of tissues including the brain, breast, lung, and liver. In addition to restraining cell proliferation and migration, miR-379 can suppress the ep...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Soudeh Ghafouri-Fard Donya Shaterabadi Afete Abak Hamed Shoorei Zahra Bahroudi Mohammad Taheri Seyed Ali Mousavinejad Source Type: research

Amyloid- β: A double agent in Alzheimer's disease?
Biomed Pharmacother. 2021 Apr 9;139:111575. doi: 10.1016/j.biopha.2021.111575. Online ahead of print.ABSTRACTAmyloid-β (Aβ) accumulation is one of the cardinal pathological hallmarks of Alzheimer's disease and plays an important role in its pathogenesis. Although the neurotoxic effects of Aβ has been extensively studied, recent studies have revealed that it may also have protective effects. Here, we review novel findings that have shifted our understanding of the role of Aβ in the pathogenesis of Alzheimer's disease. An in-depth and comprehensive understanding of Aβ will provide us with a broader p...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Hao Yu Jie Wu Source Type: research

Evaluation of serious bleeding signals during concomitant use of clopidogrel and hypnotic drugs
CONCLUSIONS: While we could not confirm or refute previously identified DDI signals, numerically elevated RRRs for serious bleeding with several clopidogrel + hypnotic pairs warrant further examination.PMID:33845372 | DOI:10.1016/j.biopha.2021.111559 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Thanh Phuong Pham Nguyen Colleen M Brensinger Warren B Bilker Sean Hennessy Charles E Leonard Source Type: research

Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up-regulation of atriopeptin
This study investigated the diuretic efficacy and underlying mechanism of a macroporous adsorption resin with 30% ethanol elution fraction from L. supina (LSC) in saline-loaded rats and to identify its phytochemicals by ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-qTOF-MS/MS). As a result, 18 phenylpropanoids, 14 flavonoids and 15 others were identified in LSC, among which stachysoside A and acteoside could be the main bio-active constituents responsible for the diuretic effect. In parallel, the daily administration of LSC (16, 32 and 64 mg/kg) markedly promoted uri...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Junwei He Li Yang Source Type: research

Antifungal activity and potential mechanism of Asiatic acid alone and in combination with fluconazole against Candida albicans
This study investigated the activity of Asiatic acid (AA) alone and in combination with fluconazole (FLC) against C. albicans in vitro and in vivo. The in vitro studies indicated that the drug combination had a synergistic effect on FLC-resistant C. albicans, with fractional inhibitory concentration index (FICI) of 0.25. And when AA at the dose of 32 µg/mL, the drug combination group could decrease the sessile minimum inhibitory concentration (sMIC) of FLC from> 1024 µg/mL to 0.125-0.25 µg/mL within 8 h against C. albicans biofilms, even with the FICI> 0.5. In vivo, the antifungal efficacy of AA use...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Yuting Wang Chunyan Lu Xia Zhao Decai Wang Yaxin Liu Shujuan Sun Source Type: research

Supplementation with ribonucleotide-based ingredient (Ribodiet ®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer
Biomed Pharmacother. 2021 Apr 9;139:111579. doi: 10.1016/j.biopha.2021.111579. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain. Additionally, increasing evidence demonstrates that a neuroinflammatory state and oxidative stress, iron-dependent, play a crucial role in the onset and disease progression. Besides conventional therapies, the use of natural-based products represents a future medical option for AD treatment and/or prevention. We, therefore, evaluated th...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2021 Category: Drugs & Pharmacology Authors: Anella Saviano Gian Marco Casillo Federica Raucci Alessia Pernice Cristina Santarcangelo Marialuisa Piccolo Maria Grazia Ferraro Miriam Ciccone Alessandro Sgherbini Nadia Pedretti Daniele Bonvicini Carlo Irace Maria Daglia Nicola Mascolo Francesco Maione Source Type: research

Probiotics-rich emulsion improves insulin signalling in Palmitate/Oleate-challenged human hepatocarcinoma cells through the modulation of Fetuin-A/TLR4-JNK-NF- κB pathway
CONCLUSION: Overall, the presented data reports clearly on the potent potential of probiotics formulated in an emulsion vehicle to enhance metabolic functions of affected IR HepG2 cells, and suggest the possibility of using such preparations as insulin sensitizing therapy, playing at the same time protective role for the development of liver related insulin resistant.PMID:33839491 | DOI:10.1016/j.biopha.2021.111560 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Malwina Mularczyk Yasmina Bourebaba Anna Kowalczuk Krzyzstof Marycz Lynda Bourebaba Source Type: research

Periplocymarin protects against myocardial fibrosis induced by β-adrenergic activation in mice
Biomed Pharmacother. 2021 Apr 8;139:111562. doi: 10.1016/j.biopha.2021.111562. Online ahead of print.ABSTRACTPeriplocymarin is an effective component of Periplocae Cortex, which was wildly used as an ingredient in Traditional Chinese Medicine. Our group previously reported that periplocymarin exerted cardiotonic role via promoting calcium influx. However, its exact role in the pathogenesis of myocardial fibrosis has not been elucidated yet. The present study was aimed at determining the potential effect and underlying mechanism of periplocymarin in isoproterenol (ISO)-induced myocardial fibrosis. C57BL/6 mice were subcutan...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Weijing Yun Lei Qian Ruqiang Yuan Hu Xu Source Type: research

Exercise and Urtica dioica extract ameliorate hippocampal insulin signaling, oxidative stress, neuroinflammation, and cognitive function in STZ-induced diabetic rats
Biomed Pharmacother. 2021 Apr 8;139:111577. doi: 10.1016/j.biopha.2021.111577. Online ahead of print.ABSTRACTINTRODUCTION: Diabetes mellitus is related to cognitive impairments and molecular abnormalities of the hippocampus. A growing body of evidence suggests that Urtica dioica (Ud) and exercise training (ET) have potential therapeutic effects on diabetes and its related complications. Therefore, we hypothesized that the combined effect of exercise training (ET) and Ud might play an important role in insulin signaling pathway, oxidative stress, neuroinflammation, and cognitive impairment in diabetic rats.METHODS: Forty an...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Masoud Rahmati Maryam Keshvari Rahim Mirnasouri Farzaneh Chehelcheraghi Source Type: research

Fe3O4 < sup > @ < /sup > piroctone olamine magnetic nanoparticles: Synthesize and therapeutic potential in cutaneous leishmaniasis
Biomed Pharmacother. 2021 Apr 8;139:111566. doi: 10.1016/j.biopha.2021.111566. Online ahead of print.ABSTRACTBACKGROUND: In recent years, magnetic nanoparticles (NMP) as novel materials have been widely used for biomedical, diagnostic and therapeutic purposes like microbial infection therapy. The purpose of this study is to synthesize PO coated iron oxide magnetic nanoparticles (Fe3O4@PO NPs) and their anti-leishmanial effects in vitro and in vivo against cutaneous leishmaniasis.METHODS: Fe3O4 magnetic nanoparticles were synthesized by the coprecipitation of Fe2 + and Fe3 + ions and used as a nanocarrier for the production...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Aishah E Albalawi Amal Khudair Khalaf Mohamed S Alyousif Abdullah D Alanazi Parastoo Baharvand Mojtaba Shakibaie Hossein Mahmoudvand Source Type: research

Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis
In conclusion, HSP plays a protective role in ISO-induced myocardial ischemia by modulating oxidative stress, inflammation, and apoptosis via Sirt1/Nrf2 pathway activation.PMID:33839495 | DOI:10.1016/j.biopha.2021.111552 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 11, 2021 Category: Drugs & Pharmacology Authors: Panpan Liu Jinghan Li Miaomiao Liu Muqing Zhang Yucong Xue Yuanyuan Zhang Xue Han Xuan Jing Li Chu Source Type: research

Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases
Biomed Pharmacother. 2021 Apr 7;139:111572. doi: 10.1016/j.biopha.2021.111572. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) represent a group of ncRNAs with more than 200 nucleotides. These RNAs can specifically regulate gene expression at both the transcriptional and the post-transcriptional levels, and increasing evidence indicates that they play vital roles in a variety of disease-related cellular processes. The lncRNA GAS8 antisense RNA 1 (GAS8-AS1, also known as C16orf3) is located in the second intron of GAS8 and has been reported to be both abnormally expressed in several diseases and closely correla...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2021 Category: Drugs & Pharmacology Authors: Ganglei Li Tiesong Zhang Kaiyuan Huang Yu Zhu Kangli Xu Jun Gu Sicong Huang Chenjie Gu Renya Zhan Jian Shen Source Type: research

Long noncoding RNA GAS8-AS1: A novel biomarker in human diseases
Biomed Pharmacother. 2021 Apr 7;139:111572. doi: 10.1016/j.biopha.2021.111572. Online ahead of print.ABSTRACTLong non-coding RNAs (lncRNAs) represent a group of ncRNAs with more than 200 nucleotides. These RNAs can specifically regulate gene expression at both the transcriptional and the post-transcriptional levels, and increasing evidence indicates that they play vital roles in a variety of disease-related cellular processes. The lncRNA GAS8 antisense RNA 1 (GAS8-AS1, also known as C16orf3) is located in the second intron of GAS8 and has been reported to be both abnormally expressed in several diseases and closely correla...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 10, 2021 Category: Drugs & Pharmacology Authors: Ganglei Li Tiesong Zhang Kaiyuan Huang Yu Zhu Kangli Xu Jun Gu Sicong Huang Chenjie Gu Renya Zhan Jian Shen Source Type: research

G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy
Biomed Pharmacother. 2021 Apr 5;139:111550. doi: 10.1016/j.biopha.2021.111550. Online ahead of print.ABSTRACTG-quadruplexes (G4) are secondary four-stranded DNA helical structures consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of several genes under proper conditions. Several cancer cells have been shown to emerge from genomic changes in the expression of crucial growth-regulating genes that allow cells to develop and begin to propagate in an undifferentiated state. Recent attempts have focused on producing treatments targeted at particular protein products of genes that are abnormall...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Annoor Awadasseid Xudong Ma Yanling Wu Wen Zhang Source Type: research

Cytoprotective effects of erythropoietin: What about the lung?
Biomed Pharmacother. 2021 Apr 5;139:111547. doi: 10.1016/j.biopha.2021.111547. Online ahead of print.ABSTRACTErythropoietin (Epo) is a pleiotropic cytokine, essential for erythropoiesis. Epo and its receptor (Epo-R) are produced by several tissues and it is now admitted that Epo displays other physiological functions than red blood cell synthesis. Indeed, Epo provides cytoprotective effects, which consist in prevention or fight against pathological processes. This perspective article reviews the various protective effects of Epo in several organs and tries to give a proof of concept about its effects in the lung. The tissu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Liasmine Haine Celine-Hivda Yegen Dominique Marchant Jean-Paul Richalet Emilie Boncoeur Nicolas Voituron Source Type: research

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats
Biomed Pharmacother. 2021 Apr 5;139:111540. doi: 10.1016/j.biopha.2021.111540. Online ahead of print.ABSTRACTIonizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Hilal Alkis Elif Demir Mehmet Resit Taysi Suleyman Sagir Seyithan Taysi Source Type: research

Pharmacokinetic study of seven bioactive components of Xiaoyan Lidan Formula in cholestatic and control rats using UPLC-MS/MS
Biomed Pharmacother. 2021 Apr 6;139:111523. doi: 10.1016/j.biopha.2021.111523. Online ahead of print.ABSTRACTA rapid, sensitive, and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed to simultaneously determine the major bioactive components of Xiaoyan Lidan Formula (XYLDF) in rat plasma, using sulfamethoxazole as the internal standard (IS). The seven major bioactive components are andrographolide, dehydroandrographolide, enmein, 1-methoxicabony-β-carboline, 4,5-dimethoxy-canthin-6-one, 4-methoxy-5-hydroxy-canthin-6-one, and 1-hydroxymethyl-β-car...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Kaihui Zhang Meiqi Wang Yufeng Yao Tao Huang Fangle Liu Chenchen Zhu Chaozhan Lin Source Type: research

G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy
Biomed Pharmacother. 2021 Apr 5;139:111550. doi: 10.1016/j.biopha.2021.111550. Online ahead of print.ABSTRACTG-quadruplexes (G4) are secondary four-stranded DNA helical structures consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of several genes under proper conditions. Several cancer cells have been shown to emerge from genomic changes in the expression of crucial growth-regulating genes that allow cells to develop and begin to propagate in an undifferentiated state. Recent attempts have focused on producing treatments targeted at particular protein products of genes that are abnormall...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Annoor Awadasseid Xudong Ma Yanling Wu Wen Zhang Source Type: research

Cytoprotective effects of erythropoietin: What about the lung?
Biomed Pharmacother. 2021 Apr 5;139:111547. doi: 10.1016/j.biopha.2021.111547. Online ahead of print.ABSTRACTErythropoietin (Epo) is a pleiotropic cytokine, essential for erythropoiesis. Epo and its receptor (Epo-R) are produced by several tissues and it is now admitted that Epo displays other physiological functions than red blood cell synthesis. Indeed, Epo provides cytoprotective effects, which consist in prevention or fight against pathological processes. This perspective article reviews the various protective effects of Epo in several organs and tries to give a proof of concept about its effects in the lung. The tissu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Liasmine Haine Celine-Hivda Yegen Dominique Marchant Jean-Paul Richalet Emilie Boncoeur Nicolas Voituron Source Type: research

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats
Biomed Pharmacother. 2021 Apr 5;139:111540. doi: 10.1016/j.biopha.2021.111540. Online ahead of print.ABSTRACTIonizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Hilal Alkis Elif Demir Mehmet Resit Taysi Suleyman Sagir Seyithan Taysi Source Type: research

Pharmacokinetic study of seven bioactive components of Xiaoyan Lidan Formula in cholestatic and control rats using UPLC-MS/MS
Biomed Pharmacother. 2021 Apr 6;139:111523. doi: 10.1016/j.biopha.2021.111523. Online ahead of print.ABSTRACTA rapid, sensitive, and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed to simultaneously determine the major bioactive components of Xiaoyan Lidan Formula (XYLDF) in rat plasma, using sulfamethoxazole as the internal standard (IS). The seven major bioactive components are andrographolide, dehydroandrographolide, enmein, 1-methoxicabony-β-carboline, 4,5-dimethoxy-canthin-6-one, 4-methoxy-5-hydroxy-canthin-6-one, and 1-hydroxymethyl-β-car...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Kaihui Zhang Meiqi Wang Yufeng Yao Tao Huang Fangle Liu Chenchen Zhu Chaozhan Lin Source Type: research

G-quadruplex stabilization via small-molecules as a potential anti-cancer strategy
Biomed Pharmacother. 2021 Apr 5;139:111550. doi: 10.1016/j.biopha.2021.111550. Online ahead of print.ABSTRACTG-quadruplexes (G4) are secondary four-stranded DNA helical structures consisting of guanine-rich nucleic acids, which can be formed in the promoter regions of several genes under proper conditions. Several cancer cells have been shown to emerge from genomic changes in the expression of crucial growth-regulating genes that allow cells to develop and begin to propagate in an undifferentiated state. Recent attempts have focused on producing treatments targeted at particular protein products of genes that are abnormall...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Annoor Awadasseid Xudong Ma Yanling Wu Wen Zhang Source Type: research

Cytoprotective effects of erythropoietin: What about the lung?
Biomed Pharmacother. 2021 Apr 5;139:111547. doi: 10.1016/j.biopha.2021.111547. Online ahead of print.ABSTRACTErythropoietin (Epo) is a pleiotropic cytokine, essential for erythropoiesis. Epo and its receptor (Epo-R) are produced by several tissues and it is now admitted that Epo displays other physiological functions than red blood cell synthesis. Indeed, Epo provides cytoprotective effects, which consist in prevention or fight against pathological processes. This perspective article reviews the various protective effects of Epo in several organs and tries to give a proof of concept about its effects in the lung. The tissu...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Liasmine Haine Celine-Hivda Yegen Dominique Marchant Jean-Paul Richalet Emilie Boncoeur Nicolas Voituron Source Type: research

Effects of Nigella sativa oil and thymoquinone on radiation-induced oxidative stress in kidney tissue of rats
Biomed Pharmacother. 2021 Apr 5;139:111540. doi: 10.1016/j.biopha.2021.111540. Online ahead of print.ABSTRACTIonizing radiation leads to release of free radicals into the systemic circulation from irradiated tissues. These free radicals cause oxidative stress in distant organs. Oxidative status may be reversed by naturally occurring antioxidant agents. The aim of this study was to investigate protective and antioxidant effects of Nigella sativa oil (NSO) and thymoquinone (TQ) in kidney tissue of rats exposed to cranial irradiation. Forty-eight Sprague-Dawley rats were divided into six groups: IR group received irradiation ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Hilal Alkis Elif Demir Mehmet Resit Taysi Suleyman Sagir Seyithan Taysi Source Type: research

Pharmacokinetic study of seven bioactive components of Xiaoyan Lidan Formula in cholestatic and control rats using UPLC-MS/MS
Biomed Pharmacother. 2021 Apr 5;139:111523. doi: 10.1016/j.biopha.2021.111523. Online ahead of print.ABSTRACTA rapid, sensitive, and reliable ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method has been developed to simultaneously determine the major bioactive components of Xiaoyan Lidan Formula (XYLDF) in rat plasma, using sulfamethoxazole as the internal standard (IS). The seven major bioactive components are andrographolide, dehydroandrographolide, enmein, 1-methoxicabony-β-carboline, 4,5-dimethoxy-canthin-6-one, 4-methoxy-5-hydroxy-canthin-6-one, and 1-hydroxymethyl-β-car...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 8, 2021 Category: Drugs & Pharmacology Authors: Kaihui Zhang Meiqi Wang Yufeng Yao Tao Huang Fangle Liu Chenchen Zhu Chaozhan Lin Source Type: research

The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro
CONCLUSIONS: In conclusion, rehmapicrogenin attenuates kidney damage by reducing inflammatory factor release through the oestrogen signalling pathway.PMID:33820633 | DOI:10.1016/j.biopha.2021.111305 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 6, 2021 Category: Drugs & Pharmacology Authors: Mengmeng Wang Yingying Ke Yage Li Zengfu Shan Wangyang Mi Yangang Cao Weisheng Feng Xiaoke Zheng Source Type: research

The nephroprotective effects and mechanisms of rehmapicrogenin include ROS inhibition via an oestrogen-like pathway both in vivo and in vitro
CONCLUSIONS: In conclusion, rehmapicrogenin attenuates kidney damage by reducing inflammatory factor release through the oestrogen signalling pathway.PMID:33820633 | DOI:10.1016/j.biopha.2021.111305 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 6, 2021 Category: Drugs & Pharmacology Authors: Mengmeng Wang Yingying Ke Yage Li Zengfu Shan Wangyang Mi Yangang Cao Weisheng Feng Xiaoke Zheng Source Type: research

Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota
In conclusion, MccJ25 effectively attenuates inflammation and improves disrupted barrier function, and the MccJ25-modified gut microbiota plays a central role in this process.PMID:33819810 | DOI:10.1016/j.biopha.2020.111127 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 5, 2021 Category: Drugs & Pharmacology Authors: Lijun Shang Haitao Yu Hongbin Liu Meixia Chen Xiangfang Zeng Shiyan Qiao Source Type: research

Recombinant antimicrobial peptide microcin J25 alleviates DSS-induced colitis via regulating intestinal barrier function and modifying gut microbiota
In conclusion, MccJ25 effectively attenuates inflammation and improves disrupted barrier function, and the MccJ25-modified gut microbiota plays a central role in this process.PMID:33819810 | DOI:10.1016/j.biopha.2020.111127 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 5, 2021 Category: Drugs & Pharmacology Authors: Lijun Shang Haitao Yu Hongbin Liu Meixia Chen Xiangfang Zeng Shiyan Qiao Source Type: research

Positive or negative anteromedial cortical support of unstable pertrochanteric femoral fractures: A finite element analysis study
CONCLUSION: The positive-positive support reduction pattern showed better mechanical stability for unstable pertrochanteric fractures. The negative-negative support reduction pattern was prone to fixation failure and should be avoided during an operation.PMID:33774311 | DOI:10.1016/j.biopha.2021.111473 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2021 Category: Drugs & Pharmacology Authors: Qin Shao Yue Zhang Gui-Xin Sun Chen-Song Yang Na Liu Da-Wei Chen Biao Cheng Source Type: research

Therapeutic and diagnostic relevance of Crispr technology
Biomed Pharmacother. 2021 Mar 25;138:111487. doi: 10.1016/j.biopha.2021.111487. Online ahead of print.ABSTRACTCRISPR is a family of DNA repeats providing immunity against viral and plasmid invading DNA in bacteria and archaea. The system consist of an endonuclease Cas, guided by a RNA sequence, able to cleave the DNA double strand at a specific site. The discovery of Crispr function in 2007 has revolutionized genetic engineering by giving to the world the most powerful and precise tool for targeted genome editing. The aim of this review is to synthesize the current knowledge on Crispr/cas system and its application in biom...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2021 Category: Drugs & Pharmacology Authors: Ibtissem El Ouar Abdelhamid Djekoun Source Type: research

Rhubarb extract relieves constipation by stimulating mucus production in the colon and altering the intestinal flora
CONCLUSION: RE could relieve constipation by promoting the secretion of colonic mucus via mast cells activation and improving the intestinal microenvironment.PMID:33774313 | DOI:10.1016/j.biopha.2021.111479 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 28, 2021 Category: Drugs & Pharmacology Authors: Chen-Chen Gao Guang-Wen Li Tian-Tian Wang Lei Gao Fei-Fei Wang Hong-Wei Shang Ze-Jun Yang Yue-Xin Guo Bo-Ya Wang Jing-Dong Xu Source Type: research