From Antioxidant to Anticancer is Vitamin C Effective in Colorectal Cancer?
Asian Pac J Cancer Prev. 2024 Apr 1;25(4):1107-1108. doi: 10.31557/APJCP.2024.25.4.1107.NO ABSTRACTPMID:38679968 | DOI:10.31557/APJCP.2024.25.4.1107 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Kanza Farhan Muhammad Burhan Tariq Ahmed Saddiq Mansha Mansoor Aliza Ahmed Abdul-Samed Mohammed Source Type: research
The mediating role of health behaviors in the association between depression, anxiety and cancer incidence: an individual participant data meta-analysis
CONCLUSIONS: Smoking constitutes a mediating pathway linking depression and anxiety to lung cancer and smoking-related cancers. Our findings underline the importance of smoking cessation interventions for persons with depression or anxiety.PMID:38680088 | DOI:10.1017/S0033291724000850 (Source: Psychological Medicine)
Source: Psychological Medicine - April 29, 2024 Category: Psychiatry Authors: Kuan-Yu Pan Lonneke van Tuijl Maartje Basten Judith J M Rijnhart Alexander de Graeff Joost Dekker Mirjam I Geerlings Adriaan Hoogendoorn Adelita V Ranchor Roel Vermeulen L ützen Portengen Adri C Voogd Jessica Abell Philip Awadalla Aartjan T F Beekman Ott Source Type: research
NestedBD: Bayesian inference of phylogenetic trees from single-cell copy number profiles under a birth-death model
Algorithms Mol Biol. 2024 Apr 29;19(1):18. doi: 10.1186/s13015-024-00264-4.ABSTRACTCopy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via "bulk sequencing," the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inf...
Source: Algorithms for Molecular Biology : AMB - April 29, 2024 Category: Molecular Biology Authors: Yushu Liu Mohammadamin Edrisi Zhi Yan Huw A Ogilvie Luay Nakhleh Source Type: research
Correlation between Pain and Anal Defecation Function in Postoperative Patients with Colorectal Cancer and Related Factors Affecting Patients' Prognosis
CONCLUSION: LARS is strongly associated with the patient's pain level, and factors such as anastomotic position <5 cm from the anal verge, preoperative radiotherapy, anastomotic fistula, high VAS level, and low MTV level will increase the risk of concurrent LARS in patients.PMID:38684502 | DOI:10.62713/aic.3173 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Yuanwei Zhang Chengjiang Xiang Jinhao Liang Source Type: research
Implications of Pretreatment Serum Carcinoembryonic Antigen Levels and Perineural Invasion with Staging, Prognosis, and Management in Stage I-III Colon Cancer after Surgery: A Retrospective Cohort Study in the SEER Database
CONCLUSION: For postoperative patients with stage I-III colon cancer, our study indicated that the CP stage is a significant prognostic factor for CSS, which deserves more clinical attention. It's worth noting that including the CP stage in the AJCC TNM staging system of colon carcinoma is beneficial to the survival prediction and clinical treatment.PMID:38684496 | DOI:10.62713/aic.3296 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Qing Zhang Li Wang Ruirui Sun Jian Gao Tingting Liu Source Type: research
OSW-1 triggers necroptosis in colorectal cancer cells through the RIPK1/RIPK3/MLKL signaling pathway facilitated by the RIPK1-p62/SQSTM1 complex
CONCLUSION: We propose that OSW-1 can induce necroptosis through the RIPK1/RIPK3/MLKL signaling pathway, and that this effect is mediated by the RIPK1-p62/SQSTM1 complex, in CRC cells. These results provide a theoretical foundation for the use of OSW-1 in the clinical treatment of CRC.PMID:38681991 | PMC:PMC11045482 | DOI:10.3748/wjg.v30.i15.2155 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Nan Wang Chao-Yang Li Teng-Fei Yao Xiao-Dan Kang Hui-Shu Guo Source Type: research
< em > Fusobacterium nucleatum < /em > -induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer
CONCLUSION: F. nucleatum can promote cancer progression through its inhibitory effect on butyric acid, via the AMPK signaling pathway.PMID:38681125 | PMC:PMC11045493 | DOI:10.3748/wjg.v30.i14.2018 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan Qing-Yong Ding Yan-Jun Zhang Ling Ji Yong-Liang Lou Xiang Li Source Type: research
Topic highlight on texture and color enhancement imaging in gastrointestinal diseases
In conclusion, TXI can improve gastrointestinal lesion detection and qualitative diagnosis. Therefore, further studies on the efficacy of TXI in clinical practice are required.PMID:38681121 | PMC:PMC11045492 | DOI:10.3748/wjg.v30.i14.1934 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 29, 2024 Category: Gastroenterology Authors: Osamu Toyoshima Toshihiro Nishizawa Keisuke Hata Source Type: research
Investigating the therapeutic potential of < em > Bifidobacterium breve < /em > and < em > Lactobacillus rhamnosus < /em > postbiotics through apoptosis induction in colorectal HT-29 cancer cells
CONCLUSION: Our research suggests that postbiotic metabolites may be effective biological products for the prevention and treatment of cancer.PMID:38682058 | PMC:PMC11055435 | DOI:10.18502/ijm.v16i1.14873 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nafiseh Erfanian Hossein Safarpour Tahmineh Tavakoli Mohammad Ali Mahdiabadi Saeed Nasseri Mohammad Hassan Namaei Source Type: research
Synergistic effects of < em > Bacillus coagulans < /em > and < em > Newcastle disease virus < /em > on human colorectal adenocarcinoma cell proliferation
CONCLUSION: It appears that utilizing oncolytic viruses (OV) and bacteria in conjunction with chemotherapy drugs could potentially aid in reducing the growth of colorectal cancer cells. However, further research is necessary, including animal studies, to confirm the efficacy of this treatment method.PMID:38682055 | PMC:PMC11055439 | DOI:10.18502/ijm.v16i1.14878 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hadi Esmaeili Gouvarchinghaleh Cyrus Jalili Maryam Zamir Nasta Fatemeh Mokhles Elmira Afrasiab Farhad Babaei Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
The Role of Delirium on Short- and Long-Term Postoperative Outcomes Following Major Gastrointestinal Surgery for Cancer
CONCLUSIONS: Postoperative delirium occurred in one in 50 patients undergoing surgical resection of a digestive tract cancer. Delirium was linked to a reduced likelihood of achieving an optimal postoperative outcome, increased ICU utilization, higher expenditures, and a worse long-term prognosis. Initiatives to prevent delirium are vital to improve postoperative outcomes among cancer surgery patients.PMID:38683304 | DOI:10.1245/s10434-024-15358-x (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Erryk S Katayama Hunter Stecko Selamawit Woldesenbet Mujtaba Khalil Muhammad Musaab Munir Yutaka Endo Diamantis Tsilimigras Timothy M Pawlik Source Type: research
Emergency Department Use in Adolescent and Young Adult Cancer Early Survivors from 2006 to 2020
Conclusion: ED utilization declined as time from diagnosis elapsed, but higher utilization was associated with social determinants of health and cancer types.PMID:38682323 | DOI:10.1089/jayao.2023.0174 (Source: Ann Oncol)
Source: Ann Oncol - April 29, 2024 Category: Cancer & Oncology Authors: Karen J Wernli Eric C Haupt Neetu Chawla Thearis Osuji Ernest Shen Andrew B Smitherman Mallory Casperson Anne C Kirchhoff Bradley J Zebrack Theresa H M Keegan Lawrence Kushi Christopher Baggett Heydon K Kaddas Kathryn J Ruddy Candice A M Sauder Theodore W Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
LncRNA ANRIL Promotes Glucose Metabolism and Proliferation of Colon Cancer in a High-Glucose Environment and is Associated with Worse Outcome in Diabetic Colon Cancer Patients
CONCLUSIONS: A high-glucose environment can increase the tumor-promoting effect of ANRIL. ANRIL can promote glucose metabolism and colon cancer proliferation by downregulating miR-186-5p with subsequent upregulation of glycolysis enzymes expression and inhibition of apoptosis.PMID:38679999 | DOI:10.31557/APJCP.2024.25.4.1371 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Hala Mosaad Sally M Shalaby Nevertety M Mahmoud Mona M Ahmed Alaa Fayed Hassan R Ashour Walaa Sarhan Source Type: research
