Cytokines as Prognostic Biomarkers of Epithelial Ovarian Cancer (EOC): A Systematic Review and Meta-Analysis
CONCLUSION: Pre-operative VEGF level in serum and tissue specimen seem to be the potential candidate of an unfavorable prognostic biomarker for EOC. The evidence was lacking to support the other cytokines investigated in blood, tissue and ascites as prognostic biomarkers for EOC.PMID:33639643 | DOI:10.31557/APJCP.2021.22.2.315 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Moh Nailul Fahmi Heru Pradjatmo Indwiani Astuti Ricvan Dana Nindrea Source Type: research

The Effect of Particle Size on the Cytotoxicity of Amorphous Silicon Dioxide: An in Vitro Toxicological Study
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):325-332. doi: 10.31557/APJCP.2021.22.2.325.ABSTRACTINTRODUCTION: Amorphous silicon dioxide (A-SiO2) is abundant in the Earth's crust, the A-SiO2 nano and microparticles are released into the air through industrial and manufacturing activities. Due to the limited available toxicological information, the objective of the present study was to evaluate the toxicity of different sizes of A-SiO2 particles on the A549 cell-lines in an in vitro study.MATERIALS AND METHODS: The A-SiO2 particles in two categories of nano (10-100 nm) and micro (
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Athena Rafieepour Mansour R Azari Jalal Pourahmad Jaktaji Fariba Khodagholi Habibollah Peirovi Yadollah Mehrabi Yousef Mohammadian Source Type: research

Physical Features and Vital Signs Predict Serum Albumin and Globulin Concentrations Using Machine Learning
CONCLUSIONS: Our models predicted serum protein concentrations with appreciable accuracy showing the promise of this approach. Such models could serve to augment existing tools for identifying "at-risk" individuals for follow-up with a blood test.PMID:33639645 | DOI:10.31557/APJCP.2021.22.2.333 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Jing Wei Jie Xiang Yousef Yasin Andrew Barszczyk Deanne Tak On Wah Meifen Yu Wendy Wenyu Huang Zhong-Ping Feng Kang Lee Hong Luo Source Type: research

Significance of HIF-1 α Expression and LOXL-2 Localization in Progression of Oral Squamous Cell Carcinoma
Conclusion: This is probably the first study to analyze LOXL-2 localization in OSCC. Alteration in the immunoexpression of LOXL-2 from nuclear to cytoplasmic and HIF-1α immunoexpression might be an important factor in progression of OSCC.PMID:33639646 | DOI:10.31557/APJCP.2021.22.2.341 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Anshul Bharti Aadithya B Urs Priya Kumar Source Type: research

The Role of English Proficiency in HPV and HPV Vaccine Awareness: A Cross-Sectional Study Across Race/Ethnicity
DISCUSSION: In order to promote health equity across race/ethnicity, language barriers among minorities should be addressed when implementing health education on HPV and the HPV vaccine.PMID:33639647 | DOI:10.31557/APJCP.2021.22.2.349 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Hee Yun Lee Yan Luo Jessica Neese Casey Daniel Hyeouk Chris Hahm Source Type: research

Prevalence of Smoke-Free Zone Compliance among Schools in Indonesia: A Nationwide Representative Survey
CONCLUSION: Although the SFZ compliance rate in Indonesian schools is 66.2% at least on 7 of 8 existed parameters, this means most of schools still aren't fully complying with the regulations for SFZs. This recent evidence will help decisionmakers to enforce tobacco control, particularly among youth, which form the pillar of national development..PMID:33639648 | DOI:10.31557/APJCP.2021.22.2.359 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Al Asyary Meita Veruswati Cut Putri Arianie Theresia Sandra Diah Ratih Aries Hamzah Source Type: research

Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):365-370. doi: 10.31557/APJCP.2021.22.2.365.ABSTRACTBACKGROUND: Despite approvals of immune checkpoint inhibitors in both small cell and non-small cell lung cancers, the role of immunotherapy in large cell neuroendocrine carcinoma (LCNEC) in lung is undefined.METHODS: Using the National Cancer Database (NCDB), Stage IV lung LCNEC cases diagnosed from 2014 to 2016 were analyzed. Information regarding cancer treatment was limited to first course of therapy, including surgery for primary lesion, radiation, chemotherapy, and immunotherapy. Survival analysis was performed using Kaplan-Me...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Takefumi Komiya Neema Ravindra Emily Powell Source Type: research

Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):371-380. doi: 10.31557/APJCP.2021.22.2.371.ABSTRACTOBJECTIVE: An impervious mortality rate in oral cancer (OC) to a certain extent explains the exigencies of precise biomarkers. Therefore, the study was intended to identify OC candidate biomarkers using samples of healthy normal tissues (N=335), adjacent normal tissues (N=93) and OC tissues (N=533) from online microarray data.METHODS: Differentially expressed genes (DEGs) were recognised through GeneSpring software (Fold change>4.0 and 'p' value.PMID:33639650 | DOI:10.31557/APJCP.2021.22.2.371 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Kinjal D Patel Hemangini H Vora Prabhudas S Patel Source Type: research

The Effect of the EGFR - Targeting Compound 3-[(4-Phenylpyrimidin-2-yl) Amino] Benzene-1-Sulfonamide (13f) against Cholangiocarcinoma Cell Lines
CONCLUSION: In summary, our study showed that 13f has potent anti-cancer activities including antiproliferation, clonogenic ability and migration through the modulation of EGFR signaling pathway in CCA for the first time. The compound represents an interesting starting point as a potential chemotherapeutic agent in ongoing efforts to improve response rate in CCA patients..PMID:33639651 | DOI:10.31557/APJCP.2021.22.2.381 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Papavee Samatiwat Lueacha Tabtimmai Prapasiri Suphakun Nattanan Jiwacharoenchai Borvorrnvat Toviwek Veerapol Kukongviriyapan M Paul Gleeson Kiattawee Choowongkomon Source Type: research

The Predictors of Sexual Satisfaction among Iranian Women with Breast Cancer
CONCLUSION: Sexual dysfunction and the low level of sexual satisfaction in patients with significant predictive effect of treatment type and sexual function denote that the patients with breast cancer need to be assisted to have proper sexual function and satisfaction leading to higher quality of life.PMID:33639652 | DOI:10.31557/APJCP.2021.22.2.391 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Nasrin Fouladi Iraj Feizi Mehriar Nadermohammadi Elham Mehrara Rozita Adldoosti Sara Alimohammadi Source Type: research

Effects of Pictorial Health Warnings on Cognitive, Affective, and Smoking Behavior: A Mixed Methods Study in Four Cities in Indonesia
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):397-405. doi: 10.31557/APJCP.2021.22.2.397.ABSTRACTWhile studies have shown the importance of pictorial health warnings (PHW) as a tobacco control strategy, empirical evidence on the efficacy of PHW in prompting smoking behavior remains inconclusive. The study aimed to examine the association between PHW and cognitive reactions, emotional/affective reactions, and smoking behavior. We conducted a mixed-methods study, which included a cross-sectional face-to-face survey of 401 smokers in four cities (Jakarta, Bandung, Semarang, and Yogyakarta) and three focus group discussions among ...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Rendro Dhani Artini Artini Sri Tunggul Pannindriya Albert Albert Abdillah Ahsan Dian Kusuma Source Type: research

Potential Utility of Cell Free High Mobility Group AT-hook 2 (HMGA2) as a Prognostic Biomarker in Liquid Biopsies of Oral Squamous Cell Carcinoma
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):407-412. doi: 10.31557/APJCP.2021.22.2.407.ABSTRACTBACKGROUND: Locoregional spread is a frequent finding in oral cancer which dictates poor prognosis. HMGA2 expression has been linked to malignant traits of oral cancer in tissue biopsies however, data on HMGA2 expression in liquid biopsies in oral cancer is sparse. Purpose of this study was to explore prognostic relevance of HMGA2 in liquid biopsies of oral cancer patients.PATIENTS AND METHODS: After obtaining approval from Institutional Review Board of Ziauddin University and informed written consent from study subjects, expressio...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Nosheen Mahmood Shamim Mushtaq Qamar Jamal Muhammad Hanif Humera Akhlaq Dur-E Shahwar Rehman Rashid Awan Source Type: research

Mobile Screening Unit (MSU) for the Implementation of the 'Screen and Treat' Programme for Cervical Cancer Prevention In Pune, India
CONCLUSION: MSUs are useful for providing cervical cancer screening services, using the 'screen and treat' strategy. Thermal ablation is safe in the field clinics. Additional efforts are needed to improve the compliance for referral of those with large lesions requiring additional visits.PMID:33639655 | DOI:10.31557/APJCP.2021.22.2.413 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Smita Joshi Richard Muwonge Vinay Kulkarni Eric Lucas Sanjeevani Kulkarni Seema Kand Mahesh Mandolkar Mufid Baig Sudhakar Wankhede Kavita Surwase Dilip Pardeshi Partha Basu Sankaranarayanan Rengaswamy Source Type: research

Key Drivers to Implement an Evidence-based Tobacco Control Programme in Schools of India: A Mixed-Methods Study
CONCLUSION: Tobacco control policies as well as training school personnel in schools need to improve and further measures must be taken to prohibit use of areca nut, which contains carcinogens. The existing system of the education department can be utilised to implement tobacco control programmes effectively.PMID:33639656 | DOI:10.31557/APJCP.2021.22.2.419 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Akash Pradhan Kunal Oswal Keyuri Adhikari Ajita Singh Rishav Kanodia Lakshman Sethuraman Ramachandran Venkataramanan Glorian Sorensen Eve Nagler Mangesh Pednekar Prakash Gupta Arnie Purushotham Source Type: research

Symptom Perceptions and Help-Seeking Behaviours of Omani Patients Diagnosed with Late-Stage Colorectal Cancer: A Qualitative Study
CONCLUSION: Patients attributed delays in CRC diagnosis to several factors based on their perceptions of symptoms. Most HSBs driven by sociocultural and emotional causes. Increased awareness of CRC symptoms and modifying HSBs can encourage early diagnosis. Prompting patients to disclose CRC-related symptoms may aid referral decisions.PMID:33639657 | DOI:10.31557/APJCP.2021.22.2.427 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Mahera Al Suqri Huda Al-Awaisi Mansour Al-Moundhri Mohammed Al-Azri Source Type: research

How Well Have Projected Lung Cancer Rates Predicted the Actual Observed Rates?
CONCLUSIONS: The agreement between projected and observed lung cancer rates is dependent on the trends in the observed rates and characteristics of the population, particularly trends in smoking.PMID:33639658 | DOI:10.31557/APJCP.2021.22.2.437 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Qingwei Luo Julia Steinberg Xue Qin Yu Michael Caruana Karen Canfell Dianne L O Rsquo Connell Source Type: research

Evaluation of the Synthesized Novel Iridium (III) Complexes Against HeLa Cell Lines Through In-Silico, In-Vitro and DNA Nicking
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):447-455. doi: 10.31557/APJCP.2021.22.2.447.ABSTRACTGlobally, the pharmaceutical industry is continuously driven in search of new anticancer drugs due to increasing rate of cancer patients. Clinical trials of Cisplatin has been explored, however, usage of Cisplatin as a drug is limited due to its various side effects, hence, alternative to platinum based complex drugs and its analogues are needed. Iridium complexes have been attracted widespread interests by virtue of their pharmacological and photo-physical properties; however the less number of complexes was reported in the litera...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: G Sathya Priyadarshini Aathi Muthusankar Ramesh Subramani Selvi Gopal Source Type: research

Effect of Intravenous Glutamine on Caspase-12 Expression in the Apoptosis of the Glomerular Epithelial Cells of Male Rats Exposed to Cisplatin
CONCLUSION: Immunohistochemical examination can be used as a marker of the nephrotoxic effect of cisplatin on the renal glomerular epithelium. Glutamine has been observed to give nephroprotective effect to cisplatin nephrotoxic effects..PMID:33639660 | DOI:10.31557/APJCP.2021.22.2.457 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Tamara Aulia Fakhrinnisa Imam Susilo Arifa Mustika Miyayu Soneta Sofyan Source Type: research

Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors
CONCLUSION: This study provided an alternative staining method for intraoperative macroscopic surgical margin evaluation, especially for rural areas without frozen section facilities.PMID:33639661 | DOI:10.31557/APJCP.2021.22.2.463 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Maulina Indah Anugrah Putri Sonar Soni Panigoro Agnes Stephanie Harahap Trevino Aristarkus Pakasi Bayu Brahma Source Type: research

Human Papillomavirus (HPV) Health Savings as an Alternative Solution: HPV Vaccination Behavior in Adolescents
This study aimed to measure the effects of reproductive health savings (tabungan kesehatan reproduksi, Takespro) on human papillomavirus (HPV) vaccine initiation program and the quality of the decision making to get vaccinated, as measured by knowledge, attitudes, beliefs, and self-efficacy toward HPV vaccination.METHODS: This quasi-experimental study was conducted on 128 students randomly allocated to intervention and control groups. This research was conducted in junior high schools. The intervention group received the health education "Takespro HPV" intervention through videos and booklets for 6 months at scho...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Wiwin Lismidiati Ova Emilia Widyawati Widyawati Source Type: research

Oral Psychosomatic Disorders in Family Caregivers of Oral Squamous Cell Carcinoma Patients
CONCLUSION: The observations of higher prevalence of oral PSDs in FCs with psychological alterations can enhance healthcare professionals' awareness to better understand FCs' oral healthcare needs..PMID:33639663 | DOI:10.31557/APJCP.2021.22.2.477 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Shailesh M Gondivkar Amol R Gadbail Sachin C Sarode Amol Hedaoo Subhrajit Dasgupta Balkrishna Sharma Apparna Sharma Monal Yuwanati Rima S Gondivkar Rahul N Gaikwad Gargi S Sarode Shankar Patil Source Type: research

Psycho-Education on Knowledge of Oral Hygiene and Psychological Distress to the Parents with Leukemia Children
CONCLUSION: Most parents whose children suffer from cancer experience psychological distress in the form of depression, anxiety and stress with a range of symptoms ranging from mild to moderate. Psycho-educational interventions can increase knowledge about oral hygiene and decrease psychological distress in parents. .PMID:33639664 | DOI:10.31557/APJCP.2021.22.2.485 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Ilya Krisnana Iqlima Dwi Kurnia Pujiati Pujiati I Dewa Gede Ugrasena Yuni Sufyanti Arief Source Type: research

Clinical Impact of Pelvic Lymph Node Status in Locally Advanced Cervical Cancer Patients Treated by Concurrent Chemoradiation Therapy
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):491-497. doi: 10.31557/APJCP.2021.22.2.491.ABSTRACTOBJECTIVE: To explore the treatment outcomes of locally advanced cervical cancer (LACC) patients with pelvic lymph node enlargement (PLNE) or stage IIIC1 when compared with no PLNE and unknown PLN status (UNK).MATERIALS AND METHODS: Retrospective cohort study was designed by matching with the ratio of 1:4:4 for patients with PLNE, no PLNE and UNK between 2003 and 2017. The main factor which was used to match was clinical staging.RESULTS: All 360 LACC patients who treated as concurrent chemoradiation therapy (CCRT) were composed of ...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Kanyarat Katanyoo Thaovalai Thavaramara Source Type: research

Socioeconomic Predictors of Trends in Cancer Mortality among Municipalities in Japan, 2010-2019
CONCLUSION: There was a difference in the trend of the SMRs of multiple types of cancer depending on municipal educational level, whereas municipalities with larger population or educational level continued to have higher SMRs of cancer in all sites for women..PMID:33639666 | DOI:10.31557/APJCP.2021.22.2.499 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Tasuku Okui Source Type: research

Roles of Salmonella typhi and Salmonella paratyphi in Gallbladder Cancer Development
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):509-516. doi: 10.31557/APJCP.2021.22.2.509.ABSTRACTBACKGROUND: Typhoid (Salmonella typhi and paratyphi) carriers and gall bladder cancer (GBC) are endemic in northern India. Results of previous studies about association of typhoid carriers with GBC are inconsistent. We studied antibodies against Salmonella typhi and paratyphi in serum samples of patients with GBC.METHODS: We performed modified Widal test for antibodies against Salmonella typhi (Vi and O) and Salmonella paratyphi (AO and BO) antigens in patients with GBC (n=100), xanthogranulomatous cholecystitis (XGC, n=24), chroni...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Ratnakar Shukla Pooja Shukla Anu Behari Dheeraj Khetan Rajendra K Chaudhary Yasuo Tsuchiya Toshikazu Ikoma Takao Asai Kazutoshi Nakamura Vinay K Kapoor Source Type: research

Cancer, Mortality, and Acute Kidney Injury among Hospitalized Patients with SARS-CoV-2 Infection
CONCLUSIONS: Patients with a history of cancer who are hospitalized with SARS-CoV-2 infection are not at greater risk for AKI, though they are at higher risk for mortality as compared to patients without a history of cancer. The increased risk in mortality appears driven by patients with pulmonary neoplasms. Patients with a history of genitourinary malignancies do not appear to be at higher risk for AKI or for mortality compared to the general population.PMID:33639668 | DOI:10.31557/APJCP.2021.22.2.517 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Johnathan A Khusid Adan Z Becerra Blair Gallante Areeba S Sadiq William M Atallah Ketan K Badani Mantu Gupta Source Type: research

Validation of Segmented Brain Tumor from MRI Images Using 3D Printingthe
CONCLUSION: When the difference in measurement of tumor volume through the electronic calipers and with 3D printed object equates to zero, proves that the segmentation technique is accurate. This helps to delineate the tumor more accurately during radio therapy.PMID:33639669 | DOI:10.31557/APJCP.2021.22.2.523 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Ujwal Ashok Nayak Mamatha Balachandra Manjunath K N Rajendra Kurady Source Type: research

Prediction for Breast Cancer in BI-RADS Category 4 Lesion Categorized by Age and Breast Composition of Women in Songklanagarind Hospital
CONCLUSION: A significantly positive association was found between PPV and age in patients in BI-RADS subcategories 4a, 4b, and 4c. This study could not determine that mammographic breast composition according to the ACR BI-RADS 5th edition was associated with PPV due to improper sample distribution.PMID:33639670 | DOI:10.31557/APJCP.2021.22.2.531 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Seechad Noonpradej Piyanun Wangkulangkul Piyanoot Woodtichartpreecha Suphawat Laohawiriyakamol Source Type: research

A Systematic Approach of Data Collection and Analysis in Medical Imaging Research
CONCLUSION: With this systematic approach of data collection and classification, analysis will be become more easier during empirical testing..PMID:33639671 | DOI:10.31557/APJCP.2021.22.2.537 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Manjunath K N Chitra Manuel Govardhan Hegde Anjali Kulkarni Rajendra Kurady Manuel K Source Type: research

Risk of High-Grade Cervical Lesions in Atypical Squamous Cells of Undetermined Significance (ASC-US) Cytology: Comparison between HIV-Infected and HIV-Negative Women
CONCLUSION: The risk of underlying high-grade cervical lesions in women with ASC-US on cervical cytology was approximately 5 %, regardless of HIV status.PMID:33639672 | DOI:10.31557/APJCP.2021.22.2.547 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Santipap Srisomboon Charuwan Tantipalakorn Tanarat Muangmool Jatupol Srisomboon Source Type: research

Histopathology and ARID1A Expression in Endometriosis- Associated Ovarian Carcinoma (EAOC) Carcinogenesis Model with Endometrial Autoimplantation and DMBA Induction
CONCLUSION: The combination of endometrial autoimplantation techniques and DMBA induction in the ovary produced atypical endometriosis, clear cell carcinoma, and endometrioid carcinoma, where time is an important factor. There was no significant difference in ARID1A expression between the treatment and control groups.PMID:33639673 | DOI:10.31557/APJCP.2021.22.2.553 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Puspita Eka Wuyung Familia Bella Rahadiati Hartono Tjahjadi Salinah Salinah Kusmardi Kusmardi Ria Kodariah Budi Wiweko Source Type: research

Frequency of Zygosity in Jak-2 Positive Patients with Polycythemia Vera-Pakistan's Perspective
CONCLUSION: JAK2V617F positive PV patients are mainly heterozygous males showing significant association with smoking and hypertension. ARMS-PCR is a robust technique to determine zygosity which can be used for screening purposes..PMID:33639674 | DOI:10.31557/APJCP.2021.22.2.559 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Syed Zubair Shah Naila Raza Muhammad Israr Nasir Syed Mustanir Hussain Zaidi Source Type: research

Impact of Fas/Fasl Gene Polymorphisms on Susceptibility Risk and Imatinib Mesylate Treatment Response in Chronic Myeloid Leukaemia Patients
CONCLUSION: The genetic polymorphism FASL-844 T>C may contribute to the CML susceptibility risk and also IM treatment response in CML patients. Accodringly, it may be useful as a biomarker for predicting CML susceptibility risk and IM resistance.PMID:33639675 | DOI:10.31557/APJCP.2021.22.2.565 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Aziati Azwari Annuar Ravindran Ankathil Nazihah Mohd Yunus Azlan Husin Nur Shafawati Ab Rajab Ahmad Aizat Abdul Aziz Mohd Ismail Ibrahim Sarina Sulong Source Type: research

Underexpression of miR-126-3p in Patients with Cholangiocarcinoma
CONCLUSION: The underexpression of mir-126-3p is associated with cholangiocarcinoma and can be potentiated by alcoholism, hypertension, diabetes, and smoking, the latter of which is an independent risk factor for this cancer. Furthermore, dCCA patients exhibit higher survival rates relative to patients with pCCA and iCCA..PMID:33639676 | DOI:10.31557/APJCP.2021.22.2.573 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Lucas Poleto Spinola Gabriel F Vieira Rafael Fernandes Ferreira Maria C J Calastri Graciele D Tenani Franciana L Aguiar Ilka F Santana Ferreira Boin Larissa B E Da Costa Maria Fernanda Chaim Correia Eliane M Zanovelo Daniele C B De Souza Rita C Martins Al Source Type: research

The Life Quality and Sexual Function of Women Underwent Radical Hysterectomy
CONCLUSION: Women who underwent RH had better health scores, global health status, and SF compared with patients treated with CRT.PMID:33639677 | DOI:10.31557/APJCP.2021.22.2.581 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Roza Pak Tolkyn Sadykova Dilyara Kaidarova Murat Gultekin Gulnara Kasimova Shynar Tanabayeva Naylia Ussebayeva Aigul Tazhiyeva Maksut Senbekov Ildar Fakhradiyev Source Type: research

The Frequency of Epidermal Growth Factor Receptor (EGFR) mutations in Iraqi patients with Non-Small Cell Lung Cancer (NSCLC)
CONCLUSION: The current study represents the first epidemiological study in Iraq to find EGFR mutations frequency among NSCLC patients that reveals the incidence rate of 27.53%, which is between the higher prevalence rate in Asian populations and lower rates in western countries. These results explain the genetic differences of NSCLC in the world due to ethnic differences of the population, more studies are needed in Arab countries to study the EGFR mutations, find the effect of ethnicity and environmental factors for lung cancer, and the subsequent therapy.PMID:33639678 | DOI:10.31557/APJCP.2021.22.2.591 (Source: Asian Pa...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Hanan H Ramadhan Dhuha F Taaban Jubran K Hassan Source Type: research

Prevalence and Potential Risk Factors of Helicobacter pylori Infection among Asymptomatic Individuals in Kazakhstan
CONCLUSIONS: More than half of the study subjects were infected with H. pylori in Kazakhstan. The prevalence of H. pylori infection was independently associated with older age and regular high salt consumption.PMID:33639679 | DOI:10.31557/APJCP.2021.22.2.597 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Linda Me žmale Inese Polaka Dace Rudzite Reinis Vangravs Ilze Kikuste Sergei Parshutin Ilva Daugule Altynbek Tazhedinov Tatyana Belikhina Nurbek Igissinov Jin Young Park Rolando Herrero Marcis Leja Source Type: research

Daidzein Induces Intrinsic Pathway of Apoptosis along with ER α/β Ratio Alteration and ROS Production
CONCLUSIONS: In conclusion, the present study suggests that Daidzein induces apoptosis in MCF-7 cells by mitochondrial pathway along with lowering the ratio of ER α/β and an outburst of Reactive Oxygen Species(ROS).PMID:33639680 | DOI:10.31557/APJCP.2021.22.2.603 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Vinod Kumar Shyam S Chauhan Source Type: research

The Effect of Metformin on Survival Outcomes of Non-Metastatic Breast Cancer Patients with Type 2 Diabetes
This study was designed to assess metformin's effect on the prognosis of female breast cancer patients with type II diabetes.METHODS: The present research was carried out as a retrospective cohort study between 2003 and 2014. Breast cancer patients with pre-existing type II diabetes mellitus were included. Overall survival (OS) and relapse-free survival (RFS) were measured as the main endpoints. Kaplan-Meier estimate was used to calculate survival rates.RESULTS: 217 patients were included with a mean age of 53.32±11.10 years. 148 (68.2%) patients were prescribed metformin and 69 (31.8%) took other antidiabetic drugs...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Bita Behrouzi Mohammad Zokaasadi Mohammad Ali Mohagheghi Amir Hosein Emami Sanambar Sadighi Source Type: research

Strong Correlation of MTHFR Gene Polymorphisms with Breast Cancer and its Prognostic Clinical Factors among Egyptian Females
CONCLUSIONS: SNPs within the MTHFR gene (C677T) and (A1289C) have strong correlation with BC among Egyptian females; These SNPs should be considered as important prognostic markers for identifying the individuals at high risk of developing BC and its progression.PMID:33639682 | DOI:10.31557/APJCP.2021.22.2.617 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Moataza H Omran Basma E Fotouh Wafaa G Shousha Abeer Ismail Noha E Ibrahim Shimaa S Ramadan Source Type: research

The Effective Control of Hyperuricemia in Cancer Patients: A New Recombinant Conjugated Variant of Urate Oxidase
CONCLUSION: Our data confirmed the efficacy and stability of PASylated UOX in comparison to the rasburicase. In summary, the results indicated that PASylated UOX drug is effective at lowering plasma uric acid levels with prolonged plasma half-life and decreased cost..PMID:33639683 | DOI:10.31557/APJCP.2021.22.2.627 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Abbas Najjari Hamid Shahbazmohammadi Eskandar Omidinia Abolfazl M Movafagh Source Type: research

Analysis of the Immunoexpression of Opioid Receptors and their Correlation with Markers of Angiogenesis, Cell Proliferation and Apoptosis in Breast Cancer
CONCLUSION: The κ-opioid receptor has a lower immunoexpression in nodal tumor metastasis with recurrence, whereas the μ-opioid receptor is directly related to expression of TUNEL-positive cells in tumors and indirectly to Ki-67 in nodal metastasis. Neither of the two receptors was expressed in the primary tumor or nodal metastasis in relation to VEGF.PMID:33639684 | DOI:10.31557/APJCP.2021.22.2.633 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Alceu Machado De Sousa Thinali Sousa Dantas Paulo Goberl ânio De Barros Silva Concei ção Da Silva Martins Gildenio Estevam Freire Howard Lopes Ribeiro Junior Gerly Anne De Castro Brito Karuza Maria Alves Pereira Renata Ferreira De Carvalho Leit ão Source Type: research

Cytokines as Prognostic Biomarkers of Epithelial Ovarian Cancer (EOC): A Systematic Review and Meta-Analysis
CONCLUSION: Pre-operative VEGF level in serum and tissue specimen seem to be the potential candidate of an unfavorable prognostic biomarker for EOC. The evidence was lacking to support the other cytokines investigated in blood, tissue and ascites as prognostic biomarkers for EOC.PMID:33639643 | DOI:10.31557/APJCP.2021.22.2.315 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Moh Nailul Fahmi Heru Pradjatmo Indwiani Astuti Ricvan Dana Nindrea Source Type: research

The Effect of Particle Size on the Cytotoxicity of Amorphous Silicon Dioxide: An in Vitro Toxicological Study
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):325-332. doi: 10.31557/APJCP.2021.22.2.325.ABSTRACTINTRODUCTION: Amorphous silicon dioxide (A-SiO2) is abundant in the Earth's crust, the A-SiO2 nano and microparticles are released into the air through industrial and manufacturing activities. Due to the limited available toxicological information, the objective of the present study was to evaluate the toxicity of different sizes of A-SiO2 particles on the A549 cell-lines in an in vitro study.MATERIALS AND METHODS: The A-SiO2 particles in two categories of nano (10-100 nm) and micro (
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Athena Rafieepour Mansour R Azari Jalal Pourahmad Jaktaji Fariba Khodagholi Habibollah Peirovi Yadollah Mehrabi Yousef Mohammadian Source Type: research

Physical Features and Vital Signs Predict Serum Albumin and Globulin Concentrations Using Machine Learning
CONCLUSIONS: Our models predicted serum protein concentrations with appreciable accuracy showing the promise of this approach. Such models could serve to augment existing tools for identifying "at-risk" individuals for follow-up with a blood test.PMID:33639645 | DOI:10.31557/APJCP.2021.22.2.333 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Jing Wei Jie Xiang Yousef Yasin Andrew Barszczyk Deanne Tak On Wah Meifen Yu Wendy Wenyu Huang Zhong-Ping Feng Kang Lee Hong Luo Source Type: research

Significance of HIF-1 α Expression and LOXL-2 Localization in Progression of Oral Squamous Cell Carcinoma
Conclusion: This is probably the first study to analyze LOXL-2 localization in OSCC. Alteration in the immunoexpression of LOXL-2 from nuclear to cytoplasmic and HIF-1α immunoexpression might be an important factor in progression of OSCC.PMID:33639646 | DOI:10.31557/APJCP.2021.22.2.341 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Anshul Bharti Aadithya B Urs Priya Kumar Source Type: research

The Role of English Proficiency in HPV and HPV Vaccine Awareness: A Cross-Sectional Study Across Race/Ethnicity
DISCUSSION: In order to promote health equity across race/ethnicity, language barriers among minorities should be addressed when implementing health education on HPV and the HPV vaccine.PMID:33639647 | DOI:10.31557/APJCP.2021.22.2.349 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Hee Yun Lee Yan Luo Jessica Neese Casey Daniel Hyeouk Chris Hahm Source Type: research

Prevalence of Smoke-Free Zone Compliance among Schools in Indonesia: A Nationwide Representative Survey
CONCLUSION: Although the SFZ compliance rate in Indonesian schools is 66.2% at least on 7 of 8 existed parameters, this means most of schools still aren't fully complying with the regulations for SFZs. This recent evidence will help decisionmakers to enforce tobacco control, particularly among youth, which form the pillar of national development..PMID:33639648 | DOI:10.31557/APJCP.2021.22.2.359 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Al Asyary Meita Veruswati Cut Putri Arianie Theresia Sandra Diah Ratih Aries Hamzah Source Type: research

Role of Immunotherapy in Stage IV Large Cell Neuroendocrine Carcinoma of the Lung
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):365-370. doi: 10.31557/APJCP.2021.22.2.365.ABSTRACTBACKGROUND: Despite approvals of immune checkpoint inhibitors in both small cell and non-small cell lung cancers, the role of immunotherapy in large cell neuroendocrine carcinoma (LCNEC) in lung is undefined.METHODS: Using the National Cancer Database (NCDB), Stage IV lung LCNEC cases diagnosed from 2014 to 2016 were analyzed. Information regarding cancer treatment was limited to first course of therapy, including surgery for primary lesion, radiation, chemotherapy, and immunotherapy. Survival analysis was performed using Kaplan-Me...
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Takefumi Komiya Neema Ravindra Emily Powell Source Type: research

Transcriptional Biomarkers in Oral Cancer: An Integrative Analysis and the Cancer Genome Atlas Validation
Asian Pac J Cancer Prev. 2021 Feb 1;22(2):371-380. doi: 10.31557/APJCP.2021.22.2.371.ABSTRACTOBJECTIVE: An impervious mortality rate in oral cancer (OC) to a certain extent explains the exigencies of precise biomarkers. Therefore, the study was intended to identify OC candidate biomarkers using samples of healthy normal tissues (N=335), adjacent normal tissues (N=93) and OC tissues (N=533) from online microarray data.METHODS: Differentially expressed genes (DEGs) were recognised through GeneSpring software (Fold change>4.0 and 'p' value.PMID:33639650 | DOI:10.31557/APJCP.2021.22.2.371 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - February 28, 2021 Category: Cancer & Oncology Authors: Kinjal D Patel Hemangini H Vora Prabhudas S Patel Source Type: research