P53 Expression in benign Breast Disease Development: A Systematic Review.
CONCLUSION: When compared with all breast tissues types, benign breast disease corresponds to 34.39% of p53 expression. Second outcomes were not evaluated because the heterogeneity observed in selected studies. In addition, more studies considering ethnicity and benign breast disease classification should also be considered for further analysis. PMID: 32986343 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Patterns of Cancer Incidence and Mortality in North- Eastern India: The First Report from the Population Based Cancer Registry of Tripura.
CONCLUSION: The data suggests that high cancer incidence and mortality are prevalent in the population of Tripura, dictating the need of active tobacco control measures, early detection and awareness drives for effective cancer control. PMID: 32986344 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

CD133 Role in Oral Carcinogenesis.
CONCLUSION: It is suggested that the CD133 cellular localization together with the histopathological criteria of OEDs classification can contribute to provide more concrete indications about the oral carcinogenesis process. PMID: 32986345 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Association between IL-27 Gene Polymorphisms and Cancer Susceptibility in Asian Population: A Meta-Analysis.
CONCLUSION: the current study findings suggest that IL-27 rs153109 polymorphism significantly increased the risk of cancer susceptibility. Well-designed replication in a larger independent genetic association study with larger sample sizes in diverse ethnicities is required to verify the findings. . PMID: 32986346 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Phylogeny and In Silico Structure Analysis of Major Capsid Protein (L1) Human Papillomavirus 45 from Indonesian Isolates.
CONCLUSION: Similar structure of Indonesian variants indicates that amino acids variations do not affect the L1 structure. However, one substitution with altered amino acid polarity found within the area of surface loop suggests a potential impact in antibody recognition and neutralization. PMID: 32986347 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Evaluation of Perienhancing Area in Differentiation between Glioblastoma and Solitary Brain Metastasis.
CONCLUSION: The ADC values of the perienhancing area were lower in glioblastoma with a near-significant p-value. Other perienhancing parameters demonstrated no significant difference between both tumors. The intratumoral necrotic area of glioblastoma is larger than metastasis.. PMID: 32986348 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Cornus Mas L improves Antioxidant Status in the Liver, Lung, Kidney, Testis and Brain of Ehrlich Ascites Tumor Bearing Mice.
In this study, the effects of Cornus Mas L (C. mas L) in different dosages on the biochemical values of mice organs were investigated in the Ehrlich Ascites tumor model, which originated from mice breast adenocarcinoma and developed in Balb/C mice. In our study, 32 Balb/C type male mice were used. Ehrlich Ascites Tumor (EAT) cells (1x106 EAT cell) from the stock animal were injected into all the mice in an intraperitoneal way. Experimental groups were given 100 and 200mg/kg C. mas L extract intraperitoneally for 9 days. The weights of the animals were recorded every day and were sacrificed on the 9th day. To estimate tumor...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Increased Expression of Oct4, Nanog and CD24 Predicts Poor Response to Chemo-Radiotherapy and Unfavourable Prognosis in Locally Advanced Oral Squamous Cell Carcinoma.
Authors: Mishra S, Tiwari V, Arora A, Gupta S, Anand N, Husain N Abstract BACKGROUND: Current study investigates the role of Oct4, Nanog and CD24 in locally-advanced oral squamous cell carcinoma (OSCC), to evaluate whether the expression of these markers can predict efficacy of neoadjuvant-chemo-radiotherapy and survival of patients. METHODS: Biomarker expression was evaluated in 50 homogenously treated patients of locally-advanced OSCC. RESULTS: Clinical response was complete in 30% (n=15), partial response in 46% (n=23), no response in 24% (n=12). Pathologically, 74% patents (n=37) were responders and 26%...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Investigations of a Possible Role of SNPs in KAI1 Gene on Its Down-Regulation in Breast Cancer.
CONCLUSION: Our findings showed no significant effect of the studied SNPs on down-regulation of KAI1 expression.. PMID: 32986351 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Frequency of OBI among Patients with Autoimmune Hepatitis.
CONCLUSION: In the present study, two OBI female patients with type 1 AIH were positive for anti-HBc but negative for HBsAg and HBV DNA. With regard to the consequences of OBI, prior to prophylactic treatment, it is recommended to screen HBV markers including anti-HBc in all diagnosed patients with AIH.. PMID: 32986352 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Predictive Value of CD44 for Prognosis in Patients with Breast Cancer.
CONCLUSION: The results from this study suggest that CD44 is clinically associated with stage of breast cancers. From the survival analysis, there was no statistical difference in overall survival and disease free survival with respect to CD44 expression. Further studies larger sample sizes are recommended for further investigation. PMID: 32986353 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Opportunities and Barriers to Breast Cancer Screening in a Rural Community in Coastal Karnataka, India: A Qualitative Analysis.
CONCLUSION: Involving cancer survivors as educators and empowering men on women's health in addition to the felt need of a patient advocate to improve accessibility were some of the highlights of the discussions. Addressing these could go a long way in improving the cancer care continuum in the region.. PMID: 32986354 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Cytotoxic Effects of Mangosteen Pericarp Extracts on Oral Cancer and Cervical Cancer Cells.
CONCLUSION: The MPE exerted significant cytotoxicity against the H357 and HeLa cells in a dose-dependent manner and promoted their apoptosis. Hence, this natural phytoextract can be considered a potent anticancer agent for treating oral cancer and cervical cancer. PMID: 32986355 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Transcriptome Profile of Next-Generation Sequencing Data Relate to Proliferation Aberration of Nasopharyngeal Carcinoma Patients in Indonesia.
This study aims to determine the differential level of gene expression in NPC patients when compared with normal individuals. Transcriptome profiling analysis was performed using RNA-Seq technology to determine the differential gene expression relate to proliferation aberration that occurs in NPC patients compared with normal individuals. So we get the transcriptomic profile of Indonesia NPC patients. METHODS: In this study, we used 9 samples, 7 NPC samples and 2 normal samples as control.  Fresh tissue of tumor samples was collected from biopsy, and normal samples were collected brushing technique. The total RNA ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Transcriptome Related to Avoiding Immune Destruction in Nasopharyngeal Cancer in Indonesian Patients Using Next-Generation Sequencing.
CONCLUSION: The results of this study suggest that the gene expression of CXCL9/10/11 have up-regulated is related to avoiding immune destruction that can use as an early detection biomarker of nasopharyngeal cancer in Indonesian patients. PMID: 32986357 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Effects of Combination of Mimic miR-155-5p and Antagonist miR-324-5p Encapsulated Chitosan in Ovarian Cancer SKOV3.
Authors: Suardi RB, Ysrafil Y, Sesotyosari SL, Martien R, Wardana T, Astuti I, Haryana SM Abstract OBJECTIVE: Ovarian cancer is a malignant tumor that attacks reproductive organs of women. MicroRNA is known to have an involvement in the prognosis of ovarian cancer. One of them is miR-155-5p which is down regulated and miR-324-5p which is up regulated. Chitosan is used as microRNA delivery system. The aims of this study is to find out the effects of combination microRNA encapsulated chitosan in cell line SKOV3. METHODS: Cell line SKOV3 obtained from Stem Cell and Cancer Institute (Kalbe). Mimic miR-155-5p and An...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Exploring Attitudes to Conception in Partners and Young Women with Gynecologic Cancers Treated by Fertility Sparing Surgery.
CONCLUSIONS: Regret and relationship breakdown were commonly reported. Women need appropriate support including inviting their partners to attend clinic appointments and may need several appointments before treatment. Regret was commonly reported by women who opted for completion surgery.. PMID: 32986359 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Expression Analysis of Fyn and Bat3 Signal Transduction Molecules in Patients with Chronic Lymphocytic Leukemia.
CONCLUSION: We have highlighted for the first time the expression of Fyn and Bat3 adaptor molecules in CLL patients. Our data demonstrated the strong correlation between the expression of Tim-3 and Fyn inhibitory molecules in CLL implying an important role for Tim-3-Fyn cooperation in induction of T-cell exhaustion. PMID: 32986360 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Reading High Breast Density Mammograms: Differences in Diagnostic Performance between Radiologists from Hong Kong SAR/Guangdong Province in China and Australia.
CONCLUSIONS: We found that younger Australian radiologists performed better at reading dense breast cases which is likely to be linked to intensive fellowship training, immersion in a screening program and exposure to the benefits of a performance-measuring education tool. PMID: 32986361 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Suppression of Rotenone-Treated Human Breast Cancer Stem Cell Survival Using Survivin Inhibitor YM155 is Associated to Oxidative Stress Modulation.
CONCLUSION: YM155 treatment could be used to overcome BCSCs resistance to oxidative stress-based anticancer therapies. PMID: 32986362 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Cost of Treatment for Cervical Cancer in India.
Authors: Singh MP, Chauhan AS, Rai B, Ghoshal S, Prinja S Abstract INTRODUCTION: Cervical cancer is a major public health problem in India leading to high economic burden, which is disproportionately borne by the patients as out-of-pocket expenditure (OOPE). Several publicly financed health insurance schemes (PFHIs) in India cover the treatment for cervical cancer. However, the provider payment rates for health benefit packages (HBP) under these PFHIs are not based on scientific evidence. We undertook this study to estimate the cost of services provided for treatment of cervical cancer and  cost of the package...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Compliance with Smoke-Free Policy and Challenges in Implementation: Evidence from Bengkulu, Indonesia.
CONCLUSION: The compliance was relatively low due to several challenges, which could serve as a tobacco control policy lesson in a lower-middle-income country. PMID: 32986364 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Ki67 and P53 Expression in Relation to Clinicopathological Features in Phyllodes Tumour of the Breast.
CONCLUSION: We found a significant association of Ki67 and p53 expressions, high mitosis and other descriptive histopathological features in malignant PT. Further study with larger sample size is recommended to predict tumour grade and prognosis as well as the disease-free survival of the tumour. . PMID: 32986365 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Clinical Significance of Annexin A4 as a Biomarker in the Early Diagnosis of Hepatocellular Carcinoma.
CONCLUSION: The serum level of ANXA4 might be a good biomarker for the early detection of HCC.. PMID: 32986366 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Association of ApaI and TaqI polymorphisms in VDR Gene with Breast Cancer.
CONCLUSIONS: Based on our results, the VDR ApaI and TaqI variations could be considered as genetic risk factors for breast cancer. However, further studies with a larger sample size are required to obtain more accurate outcomes, especially in stratified analysis. PMID: 32986367 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Anti-Proliferative Effects of Compound a and Its Effect in Combination with Cisplatin in Cholangiocarcinoma Cells.
CONCLUSIONS: These results indicate the potential of CpdA for CCA treatment. However, combination treatment with CpdA and cisplatin increased CCA cell survival. The molecular mechanism is likely attributable to promotes cell survival via the TGFβR-II signaling pathway. The combination of CpdA with other anticancer drugs for CCA treatment should be further examined. PMID: 32986368 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Impact of Caregiver's Psychological Aspects towards Quality of Life of Children with Acute Lymphoblastic Leukemia (ALL).
This study aimed to analyze the correlation between stress, anxiety, and depression in caregiver with pediatric ALL outcome. METHODS: A cross sectional study was conducted on children with ALL and their caregivers at the Pediatric Ward, Dr. Soetomo Hospital, Surabaya. Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) questionnaire were used to measure anxiety and depression in caregivers. Previous stressful experiences in children and caregivers were assessed by The Perceived Stress Scale (PSS), Children quality of life was assessed by pediatric quality of life inventory (PedsQL™) questionnaire. Pe...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Influence of Tobacco Marketing on Nepalese Adolescents: Cigarette Use and Susceptibility to Cigarette Use.
CONCLUSION: Indirect TAPS exposure increased the current, ever, and susceptibility to cigarette use among Nepalese adolescents. Overall, the current use of cigarettes followed a dose-response relationship with TAPS exposure. The result implies a requirement of active surveillance of tobacco products and future research on adolescent-focused tobacco marketing in Nepal. PMID: 32986370 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Manufacturing Industry Cancer Risk in Japan: A Multicenter Hospital-Based Case Control Study.
CONCLUSIONS: This study revealed industry risk inequalities in manufacturing categories were present with regard to the risk of common cancers in Japan. PMID: 32986371 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Association Analysis of Methylenetetrahydrofolate Reductase Common Gene Polymorphisms with Breast Cancer Risk in an Iranian Population: A Case-Control Study and a Stratified Analysis.
This study aimed to investigate the association of MTHFR C677T and A1298C genetic polymorphisms with breast cancer risk in case-control studies which was followed by stratified analysis. In the case-control study, 300 subjects including 150 women with breast cancer and 150 healthy women were enrolled. After blood sample collection, the C677T and A1298C polymorphisms genotyping were done by the PCR-RFLP method. Our data revealed a significant association between MTHFR C677T and A1298C polymorphisms and breast cancer risk. But, as a preliminary study, stratified analysis revealed no significant association between C677T and ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Incidence of and Risk Factors for Tuberculosis among Cancer Patients in Endemic Area: A Regional Cohort Study.
This study aimed to investigate risk factors for TB among cancer patients in an area with endemic TB infections. METHODS: We used the Khon Kaen population-based cancer registry and two TB databases to conduct a retrospective cohort study of cancer patients. From 2001 to 2015, we identified 40,948 eligible cancer patients. Following until 2017, we identified cases of TB diagnosed after cancer diagnosis and analyzed primary cancer site, staging, treatment, and demographic factors. Adjusted incidence rate ratios (adj. IRR) were computed to identify risk factors among a sub-set of cancer types (n = 9,733) using Poisson reg...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Effect of Obesity on Response to Neoadjuvant Therapy in Locally Advanced Gastric Cancer.
Authors: Sakin A, Sahin S, Sakin A, Aldemir MN, Bayram I, Kotan C Abstract INTRODUCTION: The effect of obesity on response to neoadjuvant chemotherapy (NACT) remains unknown. We aimed to investigate the effect of obesity on response to NACT and survival in locally-advanced gastric cancer (GC). METHODS: From 2010 to 2019, 142 GC patients with clinical stage III disease who underwent curative surgery after NACT were enrolled. Patients were divided into 3 groups according to body mass index (BMI) as follows; BMI 30 kg/m2. The Mandard tumor regression grading system was used for tumor regression grade (TRG). RE...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Association between Low Fruit and Vegetable Consumption and Colorectal Polyps in Thailand.
CONCLUSION: This study provides additional evidence of the association between low fruit and vegetable consumption and colorectal polyps. Enhancing people fiber eating behavior may help preventing colorectal cancer risk. PMID: 32986375 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Attenuation of Rat Colon Carcinogenesis by Styela plicata Aqueous Extract. Modulation of NF- κB Pathway and Cytoplasmic Sod1 Gene Expression.
CONCLUSION: Collectively, ASCex could act as a potent chemotherapeutic drug against colon cancer, likely through the influence of its rich active metabolites which interfere with various biological pathways including inhibition of protein synthesis during cellular growth and marked induction of antioxidative capacity in the colonic mucosa. This role has been extensively discussed herein. PMID: 32986376 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Integrative Bioinformatics Analysis Reveals Potential Target Genes and TNF α Signaling Inhibition by Brazilin in Metastatic Breast Cancer Cells.
CONCLUSION: In conclusion, this study identified eight PB, including MMP14, PTGS2, ADAM17, PTEN, CCL2, PIK3CB, MAP3K8, and CXCL3. In addition, brazilin possibly inhibits metastatic breast cancer through inhibition of TNFα signaling. The study results study need to be validated with in vitro and in vivo studies to strengthen scientific evidence of the use of brazilin in breast cancer metastasis inhibition. PMID: 32986377 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Transcriptome Profile of Next Generation Sequence Data Related to Inflammation on Nasopharyngeal Carcinoma Cases in Indonesia.
This study used 2 control samples taken using the brushing technique and 7 cancer samples with tissue biopsy. Isolate total RNA using Rneasy® RNA Extraction Mini Kit. Measurement of total RNA concentration and purity using a fluorometer and nanodrop Qubit. Synthesis of cDNA library uses TruSeq® RNA Library Preparation Kit V2 and concentration is measured using qPCR. Sequencing samples using NGS Illumina NextSeq 550 platform engine. Quality control results of sequencing using FASTQC, and raw data processing using HISAT2. Differential analysis of gene expression (DEGs) using edgeR and pathway analysis using DAVID and...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Network-Based Analysis Reveals Association of FOXE1 Gene Polymorphisms in Thyroid Cancer Patients; A Case-Control Study in Southeast of Iran.
In this study with the aid of systems biology approach, performed a holistic study on GSE65144 dataset containing anaplastic thyroid carcinoma tissues. Co-expression network analysis by WGCNA suggested that highly preserved turquoise module with 1,480 genes was significantly correlated to TC. Most of the top 54 hub-genes of this module are functionality correlated to thyroid hormone generation (GO:0006590). Of these 54 hub-genes, FOXE1 has been reported previously to contain mutation asosiated to TC and chosen for experimental validation step. To this end, we conducted a case-control study including 81 TC patients and 165 ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Circulation EBV Mir-Bart-7 Relating to Clinical Manifestation in Nasopharyngeal Carcinoma.
Authors: Wardana T, Gunawan L, Herawati C, Oktriani R, Anwar S, Astuti I, Aryandono T, Mubarika S Abstract OBJECTIVE: Nasopharyngeal Carcinoma (NPC) is an endemic head and neck malignancy in Asia Pacific regions that is associated with chronic infection by Epstein-Barr virus (EBV). EBV miR-BART-7 is a microRNA (miRNA) encoded by EBV that regulates malignant behavior of NPC. However, the role and function of miR-BART7 are not clear, particularly the relation of circulating levels and patient's clinical presentation. METHODS: Circulating miR-BART-7 levels were measured by using qRT-PCR and were correlated with cl...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

LTA, LEP, and TNF-a Gene Polymorphisms are Associated with Susceptibility and Overall Survival of Diffuse Large B-Cell lymphoma in an Arab Population: A Case-Control Study.
CONCLUSION: Our results confirmed the diversity and the heterogeneity of the disease. Although the study has a limitation because of its relatively small size, it clearly emphasizes the significance of ancestry and genetic composition as the determinants of DLBCL risk and behavior.. PMID: 32986381 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Coffee Consumption and Pancreatic Cancer Risk: A Meta-Epidemiological Study of Population-based Cohort Studies.
CONCLUSION: There was no association between coffee consumption habits and pancreatic cancer risk. And there was no statistical significance in the dose-response relationship between the amount of coffee consumption and pancreatic cancer risk. Finding the turning point would be important because it can be critical information for the prevention of pancreatic cancer. . PMID: 32986382 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Cross-Protective IgG and IgA Antibodies against Oncogenic and Non-Oncogenic HPV Genotypes.
Authors: Costa AP, Giraldo PC, Cobucci RN, Consolaro ML, Souza RP, Canário LB, Machado PR, Randall Martins R, Vieira Baptista P, Jr JE, Gonçalves AK Abstract OBJECTIVE: The aim of the study was to describe the course of IgG/IgA immune response in women immunized with bivalent vaccine and in women non-vaccinated with HPV infection, as well as evaluating the cross-protection against non-vaccine HPV types. METHODS: Serum and cervical mucus samples were collected from infected and vaccinated women for HPV detection/genotyping and for detection of IgG/IgA anti-HPV/VLP (Virus-like Particles) by ELISA. ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Relationship of JAK2 (V617F) Allelic Burden with Clinico- Haematological Manifestations of Philadelphia-Negative Myeloproliferative Neoplasms.
This study aimed to explore the relationship between JAK2 (V617F) allelic burden, MPN subtypes and their clinico-haematological manifestations in a Singapore-based cohort. Analysis was performed on a retrospectively collected dataset of 128 patients diagnosed with JAK2 (V617F) positive Philadelphia-negative MPNs between 2016 to 2017 in Singapore. Genomic analysis was conducted on blood samples via DNA extraction and Droplet Digital Polymerase Chain Reaction (ddPCR). The mean age was 62.4 (SD=14.1). 85 out of the 128 (66.4%) patients were male. There was a statistically significant difference in allelic burdens between the ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Changes in Spirometry Indices and Lung Cancer Mortality Risk Estimation in Concrete Workers Exposed io Crystalline Silica.
Authors: Rahimi Moghadam S, Khanjani N, Mohamadyan M, Emkani M, Yari S, Layegh Tizabi MN, Ganjali A Abstract The health of workers in the concrete and cement industries can be at risk due to occupational exposure to silica dust. The purpose of this study was to evaluate the changes of pulmonary parameters and risk of mortality from lung cancer in concrete workers exposed to crystalline silica. This cross-sectional study was performed on 72 male workers exposed to silica at a concrete manufacturing plant in Neyshabur, Iran. Respiratory zone air sampling was performed using the standard NIOSH7602 method using individ...
Source: Asian Pacific Journal of Cancer Prevention - September 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Comment on Comparison of the Outcome of Low Dose and High-Dose Corticosteroid in the Treatment of Idiopathic Granulomatous Mastitis.
Authors: Akbulut S, Sahin TT PMID: 32856839 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Comment for the "EpCAM-based Flow Cytometric Detection of Circulating Tumor Cells in Gallbladder Carcinoma Cases".
Comment for the "EpCAM-based Flow Cytometric Detection of Circulating Tumor Cells in Gallbladder Carcinoma Cases". Asian Pac J Cancer Prev. 2020 Aug 01;21(8):2179 Authors: Gullu Amuran G PMID: 32856840 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Evaluation of Khat (Catha edulis) Use as a Risk Factor of Cancer: A Systematic Review (Chong et al., 2020).
Authors: Al-Maweri SA, Al-Soneidar WA, AlQahtani KW PMID: 32856841 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Association between Tea Consumption and Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis.
CONCLUSION: This study suggests that habitual tea consumption could reduce the risk of NPC development. Additional studies are needed to further clarify the molecular role of tea in NPC risk reduction.. PMID: 32856842 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Effect of LINC01296 Expression in Patients with Cancer: A Systematic Review and Meta-Analysis.
CONCLUSION: In conclusion, the results of this meta-analysis suggest that the expression of LINC01296 might be considered as a potential biomarker in patients with cancer. PMID: 32856843 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Commentary Regarding the Effect of Long Term Use of Finasteride on Saudi Women.
Authors: Al-Qahtani WS, Albasher G, Alkahtani S Abstract In the following commentary, we provided discussions regarding an article bublished by Albasher et al. (2020) concerning the effects of long-term use of finasteride on women. They reported some adverse effects, including abnormal levels in the steroid hormones, irregular menstrual cycles, and heavy menstrual bleeding. Some concerns exist in the study mainly concerning the sample, particularly its size and composition. The authors recruited Saudi women. Thus, the findings cannot be generalized. Their study can be seen as a starting point in this regard. Even t...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The TP63 Gene Polymorphism rs17506395 is Associated with Early Breast Cancer in Cameroon.
CONCLUSION: Our data revealed an association between rs15706395 and the risk of early breast cancer onset. The GG genotype seems to reduce the risk of early breast cancer. Larger studies are needed to confirm the potential of this SNP as biomarker for breast cancer prognostic.. PMID: 32856845 [PubMed - as supplied by publisher] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2020 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research