Development of a Critical Appraisal Tool (AIMRDA) for the Peer-Review of Studies Assessing the Anticancer Activity of Natural Products: A Step towards Reproducibility
Asian Pac J Cancer Prev. 2022 Jan 2;22(12):3735-3740. doi: 10.31557/APJCP.2021.22.12.3735.ABSTRACTThe journal of APJCP (Asian Pacific Journal of Cancer Prevention) focuses to gather relevant and up-to-date novel information's related to cancer sciences. The research methodologies and approaches adopted by the researcher are prone to variation which may be desirable in the context of novel scientific findings however, the reproducibility for these studies needs to be unified and assured. The reproducibility issues are highly concerned when preclinical studies are reported in cancer, for natural products in particular. The n...
Source: Asian Pacific Journal of Cancer Prevention - January 2, 2022 Category: Cancer & Oncology Authors: Rizwan Ahmad Muhammad Riaz Mohammed Aldholmi Muhammad Asif Qureshi Shahab Uddin Ajaz Ahmad Bhat Pratheeshkumar Poyil Mukhtiar Baig Jalal Pourahmad Trivadi Ganesan Abdul Quaiyoom Khan Zainab Siddiqui Maha El-Demellawy Maryam Gholamalizadeh Dewajani Purnomo Source Type: research

lncRNA Expression-Based Risk Scoring System Can Predict Survival of Tumor-Positive Patients with Hepatocellular Carcinoma
CONCLUSION: Risk scoring system based on these lncRNAs may be useful for predicting prognosis of tumor-positive HCC patients.PMID:34967552 | DOI:10.31557/APJCP.2021.22.12.3741 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Siyao Wu Yayan Deng Yue Luo Jiaxiang Ye Zhihui Liu Source Type: research

Economic Burden of Cancer Treatment in a Region in South India: A Cross Sectional Analytical Study
CONCLUSION: Cancer care provided through public institutions had a low direct medical cost, but the indirect cost seemed to be extremely high. Public based financial assistance is the need of the hour to help the cancer affected families.PMID:34967553 | DOI:10.31557/APJCP.2021.22.12.3755 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Pradeep Kumar Maurya Sharan Murali Venkatachalam Jayaseelan Mahalakshmy Thulasingam Jagadesan Pandjatcharam Source Type: research

Prognostic Significance of Long Non Coding RNA ANRIL and SNHG14 in Acute Myeloid Leukemia
CONCLUSION: This suggests that both lnRNA ANRIL and lnRNA SNHG14 could be used in the future as prognostic biomarkers to help in treatment decisions and follow up of AML patients.PMID:34967554 | DOI:10.31557/APJCP.2021.22.12.3763 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Marwa A Gamaleldin Omar Ghallab Reham A Abo Elwafa Source Type: research

Spiritual Care Needs of Terminal Ill Cancer Patients
This study is a cross-sectional study. The participants were Thai terminal ill cancer patients from seven hospitals in northern, northeast, central, and southern regions of Thailand. Three-hundred-and-twenty-two participants were purposively selected. The instrument used in this study was a spiritual needs scale, consisting of 41 items with 4-point rating scale. Statistical analysis was F-test for one-way analysis of variance.RESULTS: The majority of terminal ill cancer patients aged fifty-one years old. Most of them were females with end stage cancer status that did not respond to treatment. The overall spiritual needs of...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Wasinee Wisesrith Pilaiporn Sukcharoen Kanittha Sripinkaew Source Type: research

Screening for Anticancer Activity of Leaf Ethanolic Extract of Alpinia elegans ("tagbak") on Human Cancer Cell Lines
In this study, Alpinia elegans leaf ethanolic extract ("tagbak," TGK) was screened for potential anti-cancer activity against lung (A549), colorectal (HCT116) and liver (HEPG2) cancer cells.METHODS: An ethanolic extract (TGK) was prepared from A. elegans leaves sampled from Infanta, Quezon. Its anti-proliferative activity on A549, HCT116 and HEPG2 was determined using MTS cell viability assay, with doxorubicin (DXR) as positive control and 0.1% DMSO in culture media as negative control. To differentiate cytostatic from cytotoxic effects, LDH cytotoxicity was performed, with 5-fluorouracil (5-FU) as positive contr...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Ryan C V Lintao Paul Mark B Medina Source Type: research

Uncovering Philip Morris International's Fundamental Strategies for Product Placement in Thailand: Spotlighting Industry Penetration to Advance the Endgame
CONCLUSION: PMAI viewed aggressive product placement as essential to success as a new entrant in Thailand, and their product placement strategies contributed substantially to capturing a large share of the market. Therefore, endgame strategies must focus on restricting product placement through surveillance of tobacco industry legal, investment and retailer actions and through stricter tobacco retailer licensing requirements and penalties.PMID:34967557 | DOI:10.31557/APJCP.2021.22.12.3789 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Naowarut Charoenca Nipapun Kungskulniti Stephen Hamann Jeremiah Mock Source Type: research

Diagnostic Accuracy of Immunohistochemistry in Detecting MGMT Methylation Status in Patients with Glioma
CONCLUSION: IHC examination can be used to detect MGMT methylation status of glioma patients in limited resources setting, where PCR technique is not available.PMID:34967558 | DOI:10.31557/APJCP.2021.22.12.3803 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Nita Sahara Rachmat Andi Hartanto Naomi Yoshuantari Kusumo Dananjoyo Irianiwati Widodo Rusdy Ghazali Malueka Ery Kus Dwianingsih Source Type: research

Effect of XPD and TP53 Gene Polymorphisms on the Risk of Platinum-Based Chemotherapy Induced Toxicity in Bangladeshi Lung Cancer Patients
CONCLUSION: These findings indicated that no significant association was found between either XPD codon 751 or TP53 codon 72 genetic polymorphisms and platinum-based chemotherapy-related toxicities in Bangladeshi lung cancer patients.PMID:34967559 | DOI:10.31557/APJCP.2021.22.12.3809 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Tahsin Nairuz Yearul Umme Bushra Yearul Kabir Source Type: research

Feasibility and Efficacy of Inspiratory Muscle Training in Patients with Head and Neck Cancer receiving Concurrent Chemoradiotherapy
CONCLUSION: Inspiratory muscle training did not show significant effect on the diaphragm thickness, mobility, and cardiorespiratory parameters; however, it was feasible, adherent, and safe in patients with HNC receiving CCRT.PMID:34967560 | DOI:10.31557/APJCP.2021.22.12.3817 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Prina Vira Stephen R Samuel Santosh Rai Pv Pu Prakash Saxena Sampath Kumar Amaravadi Nagaraja Ravishankar Diwakar D Balachandran Source Type: research

Role of Resveratrol as Radiosensitizer by Targeting Cancer Stem Cells in Radioresistant Prostate Cancer Cells (PC-3)
CONCLUSION: Resveratrol has a radiosensitizing effect, that ability is triggered by reducing the expression of cancer stem cell markers and affecting EMT markers. Resveratrol showed to be a good candidate for further studies as anticancer drug in the treatment of human prostate cancer.PMID:34967561 | DOI:10.31557/APJCP.2021.22.12.3823 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Sanaa A El-Benhawy Mohmed I Morsi Enayat I Fahmy Moustafa A Soula Fatma Al Zahraa Fh Khalil Amal Refaat Arab Source Type: research

The Effect of Gene Mutations on Metastasis and Overall Survival in Metastatic and Nonmetastatic Colon Cancers
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3839-3846. doi: 10.31557/APJCP.2021.22.12.3839.ABSTRACTOBJECTIVE: It is known that many genes are associated with colon cancer. We aimed to investigate the effect of gene mutations on metastasis and overall survival in metastatic and non metastatic colon cancers.METHODS: A total of 50 patients with metastatic (n=25) and non metastatic (n=25) diagnosed with colon cancer between 2010 and 2018 were included in the study. APC, MUTYH, RAD50, MEN1, ATM, PALB2, NSH2, BRCA1, BRCA2, MLH1, BRIP1, TP53, PTEN, BARD1, MSH6, PMS2, NBN, and FAM175A gene mutations were evaluated using the next ge...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Yesim Ozdemir Murat Cag Emel Colak Nuriye Coskun Neslihan Basgoz Hakan Sarici Dilek Kaan Muhammet Dogan Kemal Deniz Mevlude Inanc Yusuf Ozkul Source Type: research

Impact of Weight Loss on Patients with Locally Advanced Esophageal and Esophagogastric Junction Cancers Treated with Chemoradiotherapy
CONCLUSION: Significant weight loss during CRT was frequently observed in patients with locally advanced esophageal and EGJ cancers. Baseline hypoalbuminemia was an independent prognostic factor for OS in patients treated with definitive CRT. Nutritional support before and during treatment should be considered to potentially improve patients' outcomes..PMID:34967563 | DOI:10.31557/APJCP.2021.22.12.3847 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Jirapath Wiwitkeyoonwong Chuleeporn Jiarpinitnun Pitichote Hiranyatheb Nuttapong Ngamphaiboon Source Type: research

Psychometric Properties of the Bengali Version Brief Questionnaire on Smoking Urges (QSU-Brief)
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3857-3863. doi: 10.31557/APJCP.2021.22.12.3857.ABSTRACTThe study aimed to investigate the factorial structure, reliability, and validity of the Bengali version of the brief Questionnaire on Smoking Urges (QSU-Brief) tool in a sample of Bangladeshi smokers. The Bengali version QSU-Brief scale's reliability and validity were assessed on the basis of the data provided by 460 Bangladeshi smokers. To substantiate the data reliability, internal consistency and test-retest reliability were measured. Exploratory factor analysis (EFA), followed by confirmatory factor analysis (CFA), was co...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Shakil Ahmed Fabeha Tazmeem Mohammad Morshad Alam Md Golam Kibria Badrut Tamam Ahmed Bappi Bhusan Das Abdullah Al Amin Ahmed Hossain Source Type: research

The Development of Dental Informatics of Oral Cancer Screening for Prevention in Community Level: A Prototype Study in Thailand
CONCLUSIONS: Dentists have various information needs of oral cancer at the point of care. For future development of dental information or clinical decision support systems, developers should consider integrating high-quality, up-to-date clinical evidence into comprehensive and easily accessible EDRs as well as supporting dentists' resource use patterns as identified in the study.PMID:34967565 | DOI:10.31557/APJCP.2021.22.12.3865 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Vanvisa Sresumatchai Boworn Klongnoi Dechavudh Nityasuddhi Jeeranun Klaewkla Mongkol Akko Source Type: research

Target Volume Delineation Training in Radiation Oncology in India : A Survey Evaluating Its Status, the Need for Educational Programs and the Utility of Virtual Teaching
CONCLUSION: Our survey results suggest that target volume delineation training in India is deficient and virtual teaching programs can be a practical and effective way to improve it.PMID:34967566 | DOI:10.31557/APJCP.2021.22.12.3875 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Syed Touseef Ahmed Hussain Pragna Sagar Rapole Pooja Sethi Aswin Chandran Veluthattil Ninad Patil Chandramouli Ramalingam Mahalakshmy Thulasingam Source Type: research

Evaluation of Dosimetric Effect of Millennium and High Definition Multi Leaf Collimator Using 6 MV Photon Beams
CONCLUSION: It can be concluded from the results that both the MLC designs have merits and demerits that are based on their effectiveness and clinical use. However, higher surface dose was found in HD-MLC in contrast to Mi-MLC.PMID:34967567 | DOI:10.31557/APJCP.2021.22.12.3883 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Aswathi Raj D Khanna Hridya Vt Sathish Padmanabhan P Mohandass Source Type: research

Trends in Breast Cancer Incidence in Iraq During the Period 2000-2019
CONCLUSIONS: In summary, our finding revealed an increase in the incidence rates of breast cancer among Iraqi women from 2000 to 2019. Further research is needed to explore risk factors including levels of overweight, dietary changes, physical inactivity, obesity, smoking, high marriage age, and low birth rates to prevent and control breast cancer.PMID:34967568 | DOI:10.31557/APJCP.2021.22.12.3889 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Muzahem M Y Al-Hashimi Source Type: research

Fixed-Dose Recombinant Urate Oxidase in the Treatment of Paediatric Tumour Lysis Syndrome: A Regional Cancer Centre Experience
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3897-3901. doi: 10.31557/APJCP.2021.22.12.3897.ABSTRACTBACKGROUND: Tumor lysis syndrome (TLS) is an oncologic emergency commonly seen in children with hemato-lymphoid malignancies. Recombinant urate oxidase (RUO) is used in both the prophylaxis and treatment of TLS. However, in resource-constrained countries, its role is mostly limited to the treatment of established TLS and data regarding the use of RUO and its outcome is sparse.OBJECTIVE: To describe the outcome of Pediatric TLS following the use of a fixed - dose of RUO.METHODS: A retrospective chart review of all children
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Appaji L Jyothi M Reddy Pooja Gujjal Chebbi Nuthan Kumar Arun Kumar Ar Padma M Aruna Kumari B S Source Type: research

Acetaminophen Overdose Enhances Early Cholangiocarcinoma in Opisthorchiasis Hamsters
CONCLUSION: Combined intake of liver fluke-contaminated raw fishes and acetaminophen rendered more severity of CCA than sole consumption of the contaminated raw fishes.PMID:34967570 | DOI:10.31557/APJCP.2021.22.12.3903 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Pranee Sriraj Thidarut Boonmars Ratchadawan Aukkanimart Atchara Artchayasawat Glenn N Borlace Panaratana Ratanasuwan Benjamabhorn Pumhirunroj Source Type: research

Anti-Breast Cancer Activity on MCF-7 Cells of Melittin from Indonesia's Apis cerana: An In Vitro Study
CONCLUSION: Indonesia's Apis cerana has the potential to be used as a therapeutic peptide for breast cancer treatment.PMID:34967571 | DOI:10.31557/APJCP.2021.22.12.3913 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Kenny Lischer Shania Rosita Angelica Sitorus Brian Wirawan Guslianto Forbes Avila Apriliana Cahya Khayrani Muhamad Sahlan Source Type: research

Polo-Like Kinase 1(PLK1) Immunohistochemical Expression in Triple Negative Breast Carcinoma: A Probable Therapeutic Target
CONCLUSION: PLK1, although a negative prognostic factor, but is a promising therapeutic target for treating TNBC patients.PMID:34967572 | DOI:10.31557/APJCP.2021.22.12.3921 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Maha E Salama Dina A Khairy Source Type: research

Prevalence of Merkel Cell Polyomavirus (MCPyV) in the Oral Cavity Biopsies in Northern Iran
CONCLUSION: This study provides the first data from Iran regarding the presence of MCPyV genome in oral cavity lesions and oral cancer. These results also emphasize that MCPyV has an active role in the occurrence of oral lesions and progression to cancer. Further studies should be carried out to clarify the role of MCPyV in oral cavity lesions.PMID:34967573 | DOI:10.31557/APJCP.2021.22.12.3927 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Mina Hasani Estalkhi Maryam Seyed Majidi Farzin Sadeghi Mohammad Chehrazi Arghavan Zebardast Ali Hasanzadeh Yousef Yahyapour Source Type: research

Hypofractionated Hybrid Radiotherapy Techniques for Synchronous Bilateral Breast Cancer
CONCLUSION: The overall plan quality score that integrated the dosimetric parameters of PTV and OARs indicated that the 3DCRT+VMAT hybrid plan is superior for SBBC treatment.PMID:34967574 | DOI:10.31557/APJCP.2021.22.12.3933 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Karunakaran Balaji Velayudham Ramasubramanian Source Type: research

Black Turmeric and Aloe Vera in the Management of Oral Submucous Fibrosis: A Prospective Clinical Study
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3941-3947. doi: 10.31557/APJCP.2021.22.12.3941.ABSTRACTAIM: To determine the therapeutic efficacy of Kali haldi in the management of Oral submucous Fibrosis (OSMF) v/s steroid therapy.MATERIALS AND METHODS: A clinical prospective study was conducted on 42 patients of oral submucous fibrosis were equally divided into 2 groups. Group A patients were treated with a mixture of powdered Kali Haldi and aloe vera gel in equal ratio 3 times a day for 3 months. Group B patients were treated with intralesional injection of hydrocortisone and hyaluronidase for 6 weeks with oral antioxidant ...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Ankita Bohra T N Uma Maheswari Aditya Harsh Ayush Garg Source Type: research

Genomic Understanding Reveals the Important Role of FGFR2 as Paeoniflorin Target for Circumventing Breast Cancer Resistance to Tamoxifen
CONCLUSION: PF has potential to be used as a co-treatment for circumventing breast cancer resistance to tamoxifen by targeting FGFR2 signaling, but further validation is needed.PMID:34967576 | DOI:10.31557/APJCP.2021.22.12.3949 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Moh Arikus Wibowo Eri Prasetyo Nugroho Adam Hermawan Source Type: research

Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3959-3965. doi: 10.31557/APJCP.2021.22.12.3959.ABSTRACTOBJECTIVE: BCR ABL oncogene encodes the BCR-ABL chimeric protein, which is a constitutively activated non-receptor tyrosine kinase. The BCR-ABL oncoprotein is a key molecular basis for the pathogenesis of chronic myeloid leukemia (CML) via activation of several downstream signaling pathways including JAK/STAT pathway. Development of leukemia involves constitutive activation of signaling molecules including, JAK2, STAT3, STAT5A and STAT5B. Thymoquinone (TQ) is a bioactive constituent of Nigella sativa that has shown anticancer ...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Futoon Abedrabbu Al-Rawashde Wan Rohani Wan Taib Imilia Ismail Muhammad Farid Johan Abdullah Saleh Al-Wajeeh Hamid Ali Nagi Al-Jamal Source Type: research

Propensity Score-Matched Analysis of Laparoscopic versus Open Surgery for Non-Metastatic Rectal Cancer
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3967-3975. doi: 10.31557/APJCP.2021.22.12.3967.ABSTRACTBACKGROUND: Rectal cancer is a pervasive type of malignancy that accounts for one-third of colorectal cancers worldwide. Several studies have assessed the use of laparoscopic surgery as a treatment option. However, there is an ongoing debate regarding its oncological safety.METHODS: This retrospective study included 270 patients with non-metastatic rectal cancer who underwent either laparoscopic resection (LR, n = 93) or open resection (OR, n = 177) in an academic medical center. The primary outcomes were overall survival (OS)...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Kanittha Sakolprakaikij Kamthorn Yolsuriyanwong Piyanun Wangkulangkul Praisuda Bwaloy Siripong Cheewatanakornkul Source Type: research

Effects of Complementary and Alternative Medicine on Chemotherapy Delivery in Thai Patients
CONCLUSIONS: There were similar overall rates of chemotherapy schedule delay and dose reduction between CAM- and non-CAM users. However, there were less CAM-users achieving 90% chemotherapy RDI.PMID:34967579 | DOI:10.31557/APJCP.2021.22.12.3977 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Chawanya Rabiltossaporn Ploytuangporn Wongchanapai Nattaya Poovoravan Piyada Sitthideatphaiboon Virote Sriuranpong Suebpong Tanasanvimon Source Type: research

Intronic Variant of MUTYH Gene Exhibits A Strong Association with Early Onset of Breast Cancer Susceptibility in Indonesian Women Population
CONCLUSION: Despite our limitation in terms of sample size analyzed in this preliminary study, our finding on significant association of intronic MUTHY with the early onset of BC in Indonesia led to a broadened insight of population-based unique aspect to being taken into an in-depth account for and advancement of chemotherapy.PMID:34967580 | DOI:10.31557/APJCP.2021.22.12.3985 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Sonar Soni Panigoro Erlin Listiyaningsih Ika Nurlaila Bharuno Mahesworo Alam Ahmad Hidayat Arif Budiarto Digdo Sudigyo Dian Amirullah Simon Simon James Baurley Bens Pardamean Source Type: research

Combination Therapy with PIK3R3-siRNA and EGFR-TKI Erlotinib Synergistically Suppresses Glioblastoma Cell Growth In Vitro
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):3993-4000. doi: 10.31557/APJCP.2021.22.12.3993.ABSTRACTBACKGROUND: Up-regulation of PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), the regulatory subunit of PI3K is correlated with the drug resistance of the glioblastoma cells. In the present study, the effect of PIK3R3 siRNA on erlotinib sensitivity of the U373-MG glioblastoma cells was explored.METHODS: After PIK3R3 siRNA transfection, the expression of PIK3R3 mRNA was measured using RT-qPCR. Trypan blue exclusion assay was used to explore the effect of PIK3R3 siRNA on cell proliferation. The effects of PIK3R3 siRNA an...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Razieh Amini Hadi Karami Mohammad Bayat Source Type: research

Synergistic Effects of Taurine and Temozolomide Via Cell Proliferation Inhibition and Apoptotic Induction on U-251 MG Human Glioblastoma Cells
CONCLUSION: The study showed that the combination between TMZ and TAU has a potential in anticancer properties against U-251 MG manifested by the induction of G2/M arrest and apoptosis. These results suggest that this combination may be useful to enhance the efficacy and reduce some adverse events of GBM treatment in the future.PMID:34967582 | DOI:10.31557/APJCP.2021.22.12.4001 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Thanakorn Surarak Pathanin Chantree Kant Sangpairoj Source Type: research

Association between c-Myc Expression with Clinicopathological Features in T And NK Cell Lymphomas
CONCLUSION: There was no statistically significant association of clinicopathological parameters and histological subtypes of TNKcNHLs contributed by small samples tested. However, the attribution of c-Myc in this disease should be further explored.PMID:34967583 | DOI:10.31557/APJCP.2021.22.12.4011 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Nasrun Hasenan Seoparjoo Azmel Mohd Isa Faezahtul Arbaeyah Hussain Source Type: research

Camel Urine Promotes Sensitization to Doxorubicin by Inhibiting Epithelial-Mesenchymal Transition and Modulating NF- κB-Snail Signaling Pathway in Breast Cancer Cells
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4017-4029. doi: 10.31557/APJCP.2021.22.12.4017.ABSTRACTBACKGROUND: Camel urine (CU) has been used as traditional treatment in the Arabian Peninsula for centuries. Although, researchers have reported CU anti-cancer effects, the exact mechanism(s) of action involved has not been fully elucidated. The epithelial-mesenchymal transition EMT is a phenotypic switch that promotes the acquisition of a fibroblastoid-like morphology by epithelial tumor cells, resulting in enhanced tumor cell motility and invasiveness. EMT has been shown to contribute to metastasis and chemoresistance of carc...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Mashael Saqer Al-Mutairi Ibtehal Kamal Matar Suad Alfadli Awated Al-Mutairi Source Type: research

Determination of Collimator Helmet Factors for Leksell Gamma Knife 4C Unit Using GAF Chromic EBT3 Film and ImageJ Software
CONCLUSION: The measurement of CHFs in LGK 4C unit using GafChromic EBT3 film and ImageJ software is a reliable method to verify the manufacturer quoted CHFs in routine quality assurance procedures.PMID:34967585 | DOI:10.31557/APJCP.2021.22.12.4031 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Ponnusamy Natesan Senthil Manikandan Palaniappan Muthuvinayagam M K M Ganesh Malla Bhaskar Rao Source Type: research

Prediction of Response to Erythropoiesis Stimulating Agents in Low-Risk Myelodysplastic Syndromes
CONCLUSION: We conclude that a low serum EPO level is a predictive factor for responsiveness to ESAs in Asian patients with low-risk MDS.PMID:34967586 | DOI:10.31557/APJCP.2021.22.12.4037 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Saroj Hattakitpanitchakul Sirorat Kobbuaklee Kitsada Wudhikarn Chantana Polprasert Source Type: research

The Effect of miR-145-5p, DANCR and NRAS Expression Levels on the Survival Rate of Colorectal Cancer Patients
CONCLUSION: These expression levels revealed that miRNA-145-5p and NRAS can be utilized as diagnostic biomarkers in colorectal cancer death. This may also introduce the microRNAs as colorectal cancer therapeutic targets.PMID:34967587 | DOI:10.31557/APJCP.2021.22.12.4043 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Fatemeh Bahreini Masoud Saidijam Saeid Afshar Zahra Mousivand Rezvan Najafi Source Type: research

The Negative Impact of Tobacco Smoking on Health-Related Quality of Life among Saudi Adolescents During the COVID-19 Pandemic
CONCLUSION: This is the first report to explore the impact of smoking on HRQoL of Secondary Industrial Institute students in Saudi Arabia during the COVID-19 pandemic. The results indicate that smoking has a negative impact on the quality of life of vocational students. Therefore, a health strategies plan may be developed to improve the quality of life for vocational students in Saudi Arabia.OBJECTIVE: This study aimed to evaluate the impact of cigarette smoking and health-related quality of life among Saudi secondary vocational students during the COVID-19 pandemic.METHODS: A convenience sample of 328 answered a web-based...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Mohammed Sheker H Al Kalif Amal A Alghamdi Faisal M Albagmi Ali Hassan A Alnasser Source Type: research

The Prognostic Value of Cancer Stem Cell Markers in Cervical Cancer: A Systematic Review and Meta-Analysis
This study aimed to determine the role of cervical cancer stem cell (CCSC) markers for survival.MATERIALS AND METHODS: We conducted a systematic review and meta-analysis (PROSPERO CRD42021237072) of studies reporting CCSC markers as the prognostic predictor based on PRISMA guidelines. We included English articles investigating associations of CCSCs expression in tissue tumor with overall survival (OS) or disease-free survival (DFS) from PubMed, EBSCO, and The Cochrane Library databases. The quality of studies was analyzed based on Newcastle-Ottawa Quality Assessment Scale.RESULTS: From 413 publications, after study selecti...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Moh Nailul Fahmi Inge Nandya Hertapanndika Fitriyadi Kusuma Source Type: research

TGF- Β1, PNPLA3 Genetic Variants and the Risk of Hepatic Fibrosis: Correspondence
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4067. doi: 10.31557/APJCP.2021.22.12.4067.NO ABSTRACTPMID:34967590 | DOI:10.31557/APJCP.2021.22.12.4067 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Pathum Sookaromee Viroj Wiwanitkit Source Type: research

Data Driven for Early Breast Cancer Staging using Integrated Mammography and Biopsy
Conclusion: This study aims to build the models for early staging, diagnosis, and prognosis using the less aggressive method. The advantages are (1) predict staging from the first screening (2) estimate the lymph node metastases for planning to ALND or SLNB (3) evaluate overall survival time. These advantages help the physician planning the best treatment for cancer patients.PMID:34967591 | DOI:10.31557/APJCP.2021.22.12.4069 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Tongjai Yampaka Duangjai Noolek Source Type: research

The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma
CONCLUSION: It was found that the target genes are involved in vital biological processes in cancer. In detail, a total of 95 targets of miR-21 were recorded to be associated with NPC. Therefore, they may provide new insights into nasopharyngeal pathogenesis and bring about novel targets for NPC diagnosis as well as therapy in near future.PMID:34967592 | DOI:10.31557/APJCP.2021.22.12.4075 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Thuan Duc Lao Minh Trong Quang Thuy Ai Huyen Le Source Type: research

Mutational Analysis of EZH2 Gene in Patients with Colorectal Adenoma Reveals a Genetic Variant Associated with Risk of Malignant Transformation
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4085-4094. doi: 10.31557/APJCP.2021.22.12.4085.ABSTRACTBACKGROUND: Several studies have revealed that chromatin modifications lead to activation or repression of multiple genes including oncogenes and tumor suppressor genes. Inactivation mutation in EZH2 gene would result in activation of oncogenes. The aim of this case-control study was to identify mutations in the EZH2 gene, to study their prevalence among Jordanian patients with colorectal adenoma and to determine how these mutations could be related to colorectal cancer (CRC) progression.METHODS: EZH2 gene sequencing was done ...
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Amjad A Mahasneh Faten S Alnegresh Mahmoud A Alfaqih Source Type: research

lncRNA Expression-Based Risk Scoring System Can Predict Survival of Tumor-Positive Patients with Hepatocellular Carcinoma
CONCLUSION: Risk scoring system based on these lncRNAs may be useful for predicting prognosis of tumor-positive HCC patients.PMID:34967552 | DOI:10.31557/APJCP.2021.22.12.3741 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - December 30, 2021 Category: Cancer & Oncology Authors: Siyao Wu Yayan Deng Yue Luo Jiaxiang Ye Zhihui Liu Source Type: research