Association between Hepatitis B Surface Antigen Levels and the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection: Systematic Review and Meta-Analysis.
Conclusion: Our study revealed that HBsAg levels ≥ 100 IU/ml, and notably>1,000 IU/ ml, are associated with an increased risk of HCC development. PMID: 31450890 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Luminal B is the Most Common Intrinsic Molecular Subtypes of Invasive Ductal Breast Carcinoma Patients in East Kalimantan, Indonesia.
Conclusion: The study found luminal B as the most common intrinsic molecular subtypes of Indonesian breast carcinoma in the region under investigation. In the future, the higher positivity rate of luminal B in breast carcinoma patients compared to prior studies would require further investigations. PMID: 31450891 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Disparities in Epidemiological Profile of Gastric Adenocarcinoma in Selected Cities of Brazil
Conclusion: Incidence of gastric cancer is increasing in women born in the sixties in Belem (Amazon region) and Fortaleza (Northeast region). In Brazil there was increase in mortality in Northeast region and decrease in others regions. More update data on incidence for Amazon and Northeast region is needed. PMID: 31450892 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Relationship between the Methylation of Promoter Regions of Tumor Suppressor Genes PTEN and APC with Endometrial Cancer.
Conclusion: DNA methylation deficiency is a well known highlighted factor in tumorigenesis, therefore the promoter hypermethylation of PTEN and APC can be indicated as a risk factor in endometrial neoplasms. PMID: 31450893 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

IL-6 Impairs the Activity of Vitamin D3 in the Regulation of Epithelial-Mesenchymal Transition in Triple Negative Breast Cancer.
Authors: Abdel-Mohsen MA, Abo Deif SM, Abou-Shamaa LA Abstract Objective: The present study aimed to investigate the possible role of IL-6 and 1α,25-dihydroxyvitamin D3 (1,25D) signaling in epithelial-mesenchymal transition (EMT) and stemness in triple-negative breast cancer (TNBC) cell line. Methods: TNBC cell line, HCC 1806, was treated with IL-6 and 1,25D for three and six days. Also, the role of vitamin D receptor (VDR) was studied by transfection of TNBC cell line with VDR gene and transfection efficiency was assessed using Human VDR enzyme-linked immunosorbent assay (ELISA). Changes in E-cadherin gene e...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Human Cytomegalovirus DNA among Women with Breast Cancer.
Authors: Sepahvand P, Makvandi M, Samarbafzadeh A, Talaei-Zadeh A, Ranjbari N, Nisi N, Azaran A, Jalilian S, Pirmoradi R, Makvandi K, Ahmadi Angali K Abstract Breast cancer is the most common cause of death among women worldwide. Although there are many known risk factors in breast cancer development, infectious diseases have appeared as one of the important key to contribute to carcinogenesis formation. The effects of Human Cytomegalovirus (HCMV) on women with breast cancer has been recently studied and reported. To contribute to this research trend, this study was conducted to evaluate the association between HCM...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Three Markers in Cancerous and Healthy Cells of Patients with Non-Small-Cell Lung Carcinoma (NSCLC).
This study aimed to examine the expression of CEA, LUNX, and CK19 biomarkers in the cancerous and healthy tissues of patients suffering from NSCLC. Methods: In this study, 30 patients with NSCLCs referring to Masih Daneshvari Hospital in Tehran were voluntarily selected prior to taking any treatment. A tissue sample from the center and a sample of healthy tissues close to the cancerous masses were prepared by a specialist in the bronchoscopy sector and tested using real-time RT-PCR. Results: Positive CEA mRNA was observed in cancerous tissues in the center of tumors of 25 out of 30 cases. In the healthy tissue group, the s...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Identification of High-Affinity Small Molecule Targeting IDH2 for the Clinical Treatment of Acute Myeloid Leukemia.
Authors: Sweta J, Khandelwal R, Srinitha S, Pancholi R, Adhikary R, Ali MA, Nayarisser A, Vuree S, Singh SK Abstract Acute myeloid leukemia (AML) is symbolized by an increase in the number of myeloid cells in the bone marrow and an arrest in their maturation, frequently resulting in hematopoietic insufficiency (granulocytopenia, thrombocytopenia, or anemia) with or without leukocytosis either by a predominance of immature forms or a loss of normal hematopoiesis. IDH2 gene encodes for isocitrate dehydrogenase enzyme which is involved in the TCA cycle domino effect and converts isocitrate to alpha-ketoglutarate. In t...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Investigating the TLR9 mRNA Expression Level in Different Histological Types of Colorectal Polyps.
Authors: Rezasoltani S, Khatibi S, Pezeshkiyan Z, Nazemalhosseini-Mojarad E, Sharafkhah M, Sadeghi A, Asadzadeh Aghdaei H, Zali MR Abstract Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system which plays a pivotal role in inflammatory response. Recently, changing expression levels of TLR9 has been observed in a wide range of cancer cells; however, there is little information about colorectal polyps. Herein, we assessed the mRNA expression of TLR9 in different colorectal polyp types compared to normal group in order to investigate its expression level during CRC initiation. Fifty-four ...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Combined Hyperthermia and Radiation Therapy for Treatment of Hepatocellular Carcinoma.
This study is focusing on the anti-cancer activities (anti-proliferative, anti-angiogenic and antiapoptotic) of thermoradiotherapy. Materials and Methods: Liver cancer cell line (HepG2) was treated by 37oC, 40oC and 43oC hyperthermia degrees combined with three radiation doses (2 Gy, 4 Gy and 8 Gy) for 24, 48 and 72 hrs. Cell viability, apoptotic/necrotic cell screening, apoptotic (BAX and FasL) and antiapoptotic (BCL-2 and GRP78) genes, and pro-angiogenic mediators [vascular endothelial- (VEGF) and Platelet derived-growth factors (PDGF) ware investigated. Results: Our data showed that 40oC temperature combined with 4 Gy r...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Investigation of Drug Resistance Substitutions in NS3 Protease Sequence of Hepatitis C Virus from Non-Responder Patients.
Conclusion: A low frequency of PIs resistance mutations in our HCV infected population is a hopeful point of starting these drugs in HCV infected patients. PMID: 31450900 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

High Frequency of KRAS Codon 146 and FBXW7 Mutations in Thai Patients with Stage II-III Colon Cancer.
Conclusions: This study is the first to comprehensively report hotspot mutations using NGS in Thai colon cancer patients. The most commonly identified gene mutation frequencies among Thai patients (KRAS, NRAS, BRAF, TP53, and PIK3CA) were similar to the gene mutation frequencies reported in Western population, except for subgroup of KRAS codon 146 and FBXW7 mutations that had a slightly higher frequency. PMID: 31450901 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

A Correlative Study of N-Cadherin Expression with Different Grades of Oral Squamous Cell Carcinoma Projecting as a Marker of Epithelial to Mesenchymal Transition in Tumor Progression.
Authors: Rai K H, Ahmed J Abstract Background: Epithelial cells typically express E-cadherin where as N-cadherin expressed by mesenchymal cells. The epithelial to mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal cells. EMT is typical for carcinoma cells during tumor progression and correlate with the local invasiveness and metastatic potential of the tumor. Oral squamous cell carcinoma is a malignant neoplasm arising from the mucosal epithelium of the oral cavity. It can be classified...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Comparison Analysis of Linear Discriminant Analysis and Cuckoo-Search Algorithm in the Classification of Breast Cancer from Digital Mammograms.
Conclusion: The results of comparative performance analysis show that the CSA classifier outperforms the performance of LDA in terms of breast cancer classification. PMID: 31450903 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Perception of Cancer Risk and Its Associated Risk Factors among Young Iraqis living in Baghdad.
Authors: Alaa H, Shah SA Abstract Cancer is responsible for substantial burden on communities and more specifically on less developed countries. The incidence of cancer is on the rise due to population growth and aging, also due to increment of the risk factors such as smoking, increasing weight, low physical activity associated with adoption of western lifestyle. Around 14 million cases of new cancer and 8 million deaths from cancer is estimated to occur by 2012. This cross-sectional study was conducted in Baghdad from June 2016 to October 2016. Participants were selected according to our inclusion criteria, namel...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Genetic Variants Related to Cell Cycle and Stability of Telomere in Patients with Glioma.
Conclusion: Polymorphisms involved in cell cycle, telomere protection and stability and DNA repair are not associated with gliomas. On the other hand, alcohol consumption and SAH stand out as independent risk factors for the disease. Low-grade gliomas, response to treatment and the combination of chemotherapy with Temozolomide and radiation therapy show increased survival of patients. PMID: 31450905 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Nannochloropsis Extract-Mediated Synthesis of Biogenic Silver Nanoparticles, Characterization and In Vitro Assessment of Antimicrobial, Antioxidant and Cytotoxic Activities.
Conclusion: The study reveals that the microalgae-mediated AgNPs possesses potent antimicrobial and antioxidant activity along with the ability to stimulate apoptosis in A-549 cell line. PMID: 31450906 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Evaluation of Neutrophil-Lymphocyte Ratio as a Prognostic Factor in Cervical Intraepithelial Neoplasia Recurrence.
Authors: Farzaneh F, Faghih N, Hosseini MS, Arab M, Ashrafganjoei T, Bahman A Abstract Background: Immune system status is a factor related to cervical intraepithelial neoplasia (CIN) recurrence. neutrophil-lymphocyte ratio (NLR) is a useful factor in assessing the immune status. The aim of this study was to evaluate the prognostic value of NLR factor for CIN recurrence in patient who underwent excisional procedure and its relationship with recurrence free survival (RFS). Methods: In this historical cohort study, a population of 307 patients with CIN (confirmed by excisional pathology) from 2009 to 2017 were select...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Stage of Breast Cancer Screening Adoption; The Role of Cognitive Predictors.
Authors: Naimi E, Mirzaei-Alavijeh M, Ahmadi-Jouybari T, Ataee M, Aghaei A, Ahmadi Jouybari H Abstract Breast cancer is the most common cancer among women. The present study investigated the stage of breast cancer screening adoption and the role of some of the cognitive predictors in a sample of Iranian married women. There were a total of 334 married women clients of eight health centers in Kermanshah city, the west of Iran, were randomly selected to participate voluntarily. Women filled out a self-report questionnaire. Data were analyzed by SPSS version 20 using One-way ANOVA, χ2-test, Fisher’s exact te...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

microRNA-21 Expression as Prognostic and Therapeutic Response Marker in Chronic Myeloid Leukaemia Patients.
Authors: Mirza MAB, Guru SA, Abdullah SM, Rizvi A, Saxena A Abstract Background: Chronic myeloid leukaemia (CML) is a myeloproliferative disorder categorized by malignant transformation of a single stem cell of hematopoietic cells. microRNAs (miRNAs) belong to transcription regulators in hematopoiesis and their altered expression associates with pathogenesis of CML. Aim: Current study aimed to access the miR-21 expression profile in CML patients and therapy response as well as its prognostic significance. Methods: 100 CML cases, 100 controls were included in study and miR-21 expression was analyzed. Overall 9.22 me...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Gail Model Underestimates Breast Cancer Risk in Thai Population.
Conclusion: The Gail model underestimated the risk of breast cancer in Thai women. Calibration of the model is still required before adoption in Thai population. PMID: 31450910 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Retrospective Study of the Effect of Statins on the Outcome of Lung Cancer Patients, University of Cincinnati Experience.
Conclusion: While showing an increase in overall survival in patients with advanced lung cancer, the results of this study did not reach statistical significance. This could be due for the small sample size of this retrospective study. PMID: 31450911 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Risk Modulation of Oral Pre Cancer and Cancer with Polymorphisms in XPD and XPG Genes in North Indian Population.
Conclusion: This work shows association of XPD (A/C), XPG (G/C) polymorphisms with the development of pre oral cancer as well as oral cancer and its clinical courses. PMID: 31450912 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Application Value of Serum HE4 in the Diagnosis of Lung Cancer.
Authors: Wang Y, Wang Z, Ding Y, Sun F, Ding X Abstract Background: To investigate the clinical value of HE4 detection in the diagnosis of lung cancer and the clinical significance of combined detection with CEA, NSE and CYFRA21-1. Methods: 90 cases of lung cancer, 30 cases of pulmonary tuberculosis, 30 cases of pneumonia and 30 cases of health physical examination were selected. The levels of serum HE4, CYFRA21-1, CEA and NSE were detected by electrochemiluminescence method. Statistical analysis was performed to observe the sensitivity and specificity. Results: The levels of serum HE4, CEA, NSE and CYFRA21-1 in lu...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Utility of Urine-Based Sampling for Cervical Cancer Screening in Low-Resource Settings.
Conclusion: Even though not acceptable as an HPV DNA screening tool due to low sensitivity, the urine sampling method is inexpensive and more socially acceptable for large epidemiological surveys in developing countries to estimate the burden. PMID: 31450914 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Sequential Administration of EGFR-TKI and Pemetrexed Achieved a Long Duration of Response in Advanced NSCLC Patients with EGFR-mutant Tumours.
Conclusions: The sequential administration of TKI and pemetrexed chemotherapy achieved a long PFS and was a suitable treatment for advanced NSCLC. PMID: 31450915 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Chemotherapeutic Resistance in Egyptian Acute Myeloid Leukemia Patients.
Authors: Kassem NM, Medhat N, Kassem HA, El-Desouky MA Abstract Background: Acute Myeloid Leukemia (AML) is a heterogeneous disorder with variable genetic abnormalities and cytogenetic alterations which provide a significant disease prognosis and determine response to therapy. Purpose: We aim to investigate the expression of the MDR1 gene in 100 Egyptian AML patients, to identify their role on both the progression and chemotherapeutic refractoriness together with assessment of known prognostic molecular markers; FLT3-ITD and NPM1 mutations. Methodology: Quantitative assessment of MDR1 gene expression was performed ...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

A Qualitative Study of Parental Knowledge and Perceptions of Human Papillomavirus and Cervical Cancer Prevention in Rural Central Java, Indonesia: Understanding Community Readiness for Prevention Interventions.
Conclusions: Extensive community education about HPV and CC, targeting women and men, adolescents, health workers and teachers, is crucial to support the introduction of the HPV Demonstration Program and the upscaling of CC screening. Low incomes among rural families underline the need for the HPV vaccine to be provided free within the National Immunization Program, and for CC screening to be free at primary health clinics. PMID: 31450917 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

An Internal Control for Evaluating Bisulfite Conversion in the Analysis of Short Stature Homeobox 2 Methylation in Lung Cancer.
In this study, we designed an artificial internal control (IC) system that contained the cytosine-free fragment (CFF) following CpG sequences of the SHOX2 promoter whose methylation status has been described as a valuable biomarker of lung cancer. Its performance in quantifying DNA recovery and bisulfite conversion efficiency as well as in detecting false-positive SHOX2 methylation was determined on samples from lung cancer patients. Material and Methods: The IC system is composed of two pConIC and pUnIC plasmids that both contain a cytosine-free (CF) sequence derived from the CFF and the CpG containing SHOX2 sequences. Th...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Transcriptome and Network Dissection of Microsatellite Stable and Highly Instable Colorectal Cancer.
Conclusion: Our results can explain why MSI and MSS CRC display different immunotherapy response, prognosis, and metastasis feature. Moreover, our predicted up-stream regulators in the regulatory networks may be promising therapeutic targets. PMID: 31450919 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Transcriptional Regulation of Epithelial to Mesenchymal Transition Related Genes by Lipopolysaccharide in Human Cervical Cancer Cell Line HeLa.
Conclusion: The result of this study, LPS is able to reduce E-cadherin expression, caused by increase in repressor E-cadherin protein expression and some microRNAs, probably. Since bacterial infection can be in cervical site, it is likely to be effective in reducing the E-cadherin expression in the EMT and enhance cancer process, therefore; removing these infections by using the appropriate antibiotics may result in slowing down this process, which requires more research. PMID: 31450920 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Physical and Radiobiological Evaluation of Accelerated Intensity Modulated Radiotherapy for Locally Advanced Head and Neck Cancer and Comparison with Short-Term Clinical Outcomes.
Conclusion: The mean QF based on UPI was found to be close to unity, which correlates with being a better IMRT plan. The present study suggested the existence of a moderate correlation between the calculated NTCP values and their respective severities of the organ at risk (OAR’s). Accelerated IMRT with chemotherapy is a clinically feasible option in the treatment of locally advanced head and neck squamous cell carcinoma (HNSCC) with encouraging initial tumor response and acceptable acute toxicities. PMID: 31450921 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Prognostic Significance of Cyclin D1 Over-expression in Colorectal Cancer: An Experience from Madinah, Saudi Arabia.
Conclusion: Cyclin D1 over-expression increases during normal-adenoma-carcinoma sequence. The significant association observed between Cyclin D1 over-expression, advanced tumor stage and short survival period clearly suggest the role of Cyclin D1 in the carcinogenesis and progression of CRC. PMID: 31450922 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Risk of Acute Lymphoblastic Leukemia: Results of a Case-Control Study.
Conclusion: This study showed that father’s education level, father’s job, delivery type, birth weight, and childcare can play a role in the incidence of childhood ALL. PMID: 31450923 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Studies on Fundamental Interaction Parameters for Stainless Steel and Titanium Biomaterials Using Flattened and Un-Flattened Megavoltage X-Ray Beams.
Conclusion: This study elaborated the fundamental interaction parameters of different energies of flattened and unflattened x-ray beam interactions with high Z materials such as Stainless Steel (SS316) and Titanium (Grade5) relevant in a clinical scenario. PMID: 31450924 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Gene Combination of CD44 rs187116, CD133 rs2240688, NF- κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand.
Gene Combination of CD44 rs187116, CD133 rs2240688, NF-κB1 rs28362491 and GSTM1 Deletion as a Potential Biomarker in Risk Prediction of Breast Cancer in Lower Northern Thailand. Asian Pac J Cancer Prev. 2019 08 01;20(8):2493-2502 Authors: Sapcharoen K, Sanguansermsri P, Yasothornsrikul S, Muisuk K, Srikummool M Abstract Background: Biomarkers play an important role in oncology, including risk assessment, treatment prediction, and monitoring the progression of disease. In breast cancer, many genes are used as biomarkers. Since, several SNP variations of hallmark – related genes have been rep...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Dual Glycation-Inflammation Modulation, DPP-IV and Pancraetic Lipase Inhibitory Potentials and Antiproliferative Activity of Novel Fluoroquinolones.
In conclusion, FQ and TFQ derivatives may unveil new antiobesity and anticancer agents in the future. Our research qualifies FQs and TFQs as promising candidates for the development of related α-dicarbonyl scavengers as therapeutic agents to protect cells against carbonyl stress. PMID: 31450926 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Diagnostic Performance of microRNA-122 and microRNA-224 in Hepatitis C Virus-Induced Hepatocellular Carcinoma (HCC).
This study examined two miRNAs which are miRNA-122 and miRNA-224 if it could serve as biomarkers for diagnosis of HCC. Methods: This study included 20 patients with HCV-induced HCC and 20 patients with HCV-induced liver cirrhosis for comparison. As well as 20 healthy volunteers as controls. All participants were subjected to history taking, clinical examination, and determination of serum alpha-fetoprotein. Quantification of plasma miRNA-122 and miRNA-224 was done by real-time quantitative PCR. Results: Our results showed that levels of miRNA-122 were significantly lower in HCC group compared to the cirrhosis group and con...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Methylation of Glutathione-S-Transferase P1 Promotor in Egyptian Females with Breast Cancer.
Conclusion: Glutathione-S-Transferase P1 Promotor methylation plays a role in breast cancer development. PMID: 31450928 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

An Assessment of Dosimetric Characteristics of Inline 2.5 Mega Voltage Unflattened Imaging X-Ray Beam.
Authors: Rajamanickam T, Muthu S, Murugan P, Dinesan C, Mekala C, Senthilnathan K, Arunai Nambi Raj N, Ramesh Babu P Abstract Purpose: The aim of this work is to study the dosimetric parameters of newly introduced 2.5 MV imaging x-ray beam used as inline imaging to do setup verification of the patient undergoing radiation therapy. As this x-ray beam is in megavoltage range but comprises of a lower energy spectrum. It is essential to study the pros and cons of 2.5 MV imaging x-ray beam for clinical use.Methods: The mean energy was calculated using the NIST XCOM table through MAC. Profile analysis was done using RFA ...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Counselling as a Tool for Tobacco Cessation in a Dental Institution: Insights from India.
Authors: Rajesh G, Pinto AS, Binnal A, Naik D, Rao A Abstract Background: Tobacco related mortality and morbidity is a growing public health problem world over. Counselling has emerged as an important arsenal in the battle against tobacco. Involving experts other than traditional medical health workers may be critical. Aim of the present study was to explore various aspects related to Tobacco cessation counselling among Indian dental students. Methods: Overall, 241 undergraduate students from Manipal College of Dental Sciences, Mangalore participated in the present investigation. A structured, pretested, self-admin...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Carcinogenic Agent Diethylnitrosamine Induces Early Oxidative Stress, Inflammation and Proliferation in Rat Liver, Stomach and Colon: Protective Effect of Ginger Extract.
Conclusion: GE exerted a potential anti-proliferative activity against DENA in liver, stomach and colon via Nrf2 activation, whilst suppression of oxidation and inflammation. PMID: 31450931 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Preliminary In Vitro Effects of CD8+ T Lymphocyte Specific for the CD20 Alternative Splicing D393-CD20 Peptide Expressed on Burkitt Lymphoma Cells.
In this study, we want use from T CD8+ against D393-CD20 for effect in RAMOS cell line. After isolation and expanding of specific TCD8 + Lymphocyte against D393-CD20 antigen, for examining the effect of specialized T lymphocyte clone of D393-CD20 antigen on RAMOS cell line, we co-cultured them together, and the rate of apoptosis were examined by flow cytometry and cytotoxicity techniques by using MTT technique. We observed that specialized TCD8+ lymphocyte of D393-CD20 antigen can induce apoptosis in malignant B-lymphocytes, and this antigen can be a proper target for immunotherapy. PMID: 31450932 [PubMed - in process]...
Source: Asian Pacific Journal of Cancer Prevention - August 29, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Extraordinary Claims Don't always Require Extraordinary Evidence, but They Do Require Good Quality Evidence.
Authors: Hawkes D PMID: 31350947 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Interleukin-10 (1082G/A) Polymorphism is Associated with Susceptibility of Acute Myeloid Leukemia Patients in Sudanese Population.
CONCLUSION: Our study concluded that GA genotype of IL-10 -1082G/A (rs1800896) polymorphism is arisk factor for AML and G allele is insignificantly higher than A allele in AML patient. No association between IL-10(-1082G/A) polymorphism and AML sub-type, gender, age group, mean of hematological parameters. PMID: 31350948 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Knowledge and Attitude Toward Human Papillomavirus and HPV Vaccination in Iranian Population: A Systematic Review.
CONCLUSION: Due to the low levels of knowledge about HPVinfection and its methods of prevention, efforts should be increased to enhance the knowledge of the general populationabout HPV infection and vaccination in order to prevent its incidence and complications. PMID: 31350949 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Association of Promoter Region Polymorphisms of IL-10 Gene with Susceptibility to Lung Cancer: Systematic Review and Meta-Analysis.
CONCLUSIONS: Our meta-analysis suggests that the IL-10 -592A>C polymorphism mightbe risk factor for lung cancer, especially among Asian and Caucasians. In contrast, the IL-10 -819T>C and -1082A>Gpolymorphisms are not significantly associated with increased risk of lung cancer. PMID: 31350950 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Cluster Analysis Evaluating PM2.5, Occupation Risk and Mode of Transportation as Surrogates for Air-pollution and the Impact on Lung Cancer Diagnosis and 1-Year Mortality.
This study concurred withprevious studies that lung adenocarcinoma were diagnosed in predominantly younger, female non-smokers comparedto the other types of lung cancers. Lung adenocarcinoma subjects had annual PM2.5 that was almost twice higher thansquamous cell carcinoma, small cell carcinoma and other histological subtypes (p=0.024). Independent of smoking,the κ -means cluster analysis revealed two clusters in which the high risk cluster involves occupation risk with airpollution of more than four hours per day, main transportation involving motorcycle and trucks and mean annual PM2.5concentration of more than 30 ...
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Efficacy of Implementing Home Care Using Eye Movement Desensitization and Reprocessing in Reducing Stress of Patients with Gastrointestinal Cancer.
This study was conducted to determine theeffect of home care using EMDR technique on the stress of patients with gastrointestinal cancer. Materials andMethods: The current semi-experimental study was performed on patients with gastrointestinal cancer residing inIlam, Iran. The patients were randomly divided into two groups of intervention (n=30) and control (n=30). Homecare was provided for intervention group in patients' homes which included 2 sessions (a total of 60 sessions for allpatients). Each session lasted for 45 to 60 minutes according to EMDR protocol. The data were analyzed using SPSS(version 16). RESULTS: T...
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Assessment of the Blood Parameters, Cardiac and Liver Enzymes in Oral Squamous Cell Carcinoma Following Treated with Injectable Doxorubicin-Loaded Nano-Particles.
CONCLUSION: The results of this research showed that significant decreases in haematological changesoccurred, including leukopenia and anemia, in an animal model of OSCC induced by 4-NQO following use of n-Doxwith compare to Dox. Use of n-Dox is better than of Dox for treatment of OSCC. PMID: 31350953 [PubMed - in process] (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - July 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research