Effect of Vitamin D Deficiency on Liver Cancer Risk: A Systematic Review and Meta-Analysis
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):991-997. doi: 10.31557/APJCP.2021.22.4.991.ABSTRACTEpidemiological studies have showed that vitamin D deficiency can increase the risk of liver cancers. Hence, we conducted a meta-analysis to explore the relationship between 25-hydroxyvitamin D [25(OH)D] levels and liver cancer risk.METHODS: Cochrane Library, Medline, Web of Science, and Embase were searched up to Mar. 2020, and the references of those studies were also searched by hand. A meta-analysis of 11 studies was performed which met the inclusion criteria. Six case-control studies and five cohort studies were included.RESUL...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Zhenghui Yi Linjie Wang Xiangqun Tu Source Type: research

Role of microRNAs in Predicting the Prognosis of Cervical Cancer Cases: A Systematic Review and Meta-Analysis
CONCLUSION: The downregulation of aberrant miRNAs was not associated with poor overall survival rates.PMID:33906290 | DOI:10.31557/APJCP.2021.22.4.999 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Sasidharanpillai Sabeena Nagaraja Ravishankar Source Type: research

Determinants of Delayed Presentation and Advanced-Stage Diagnosis of Breast Cancer in Africa: A Systematic Review and Meta-Analysis
CONCLUSION: Promoting early presentation and reducing advanced-stage BC throughout Africa should focus on modifiable factors, including providing quality education, improving breast health awareness and BC knowledge, and developing strategies to increase BSE and CBE. Interventions targeting socio-demographic determinants should be context-specific.PMID:33906291 | DOI:10.31557/APJCP.2021.22.4.1007 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Olayide Agodirin Isiaka Aremu Ganiyu Rahman Samuel Olatoke Julius Olaogun Halimat Akande Anya Romanoff Source Type: research

RET Protein Expression in Colorectal Cancer; An Immunohistochemical Assessment
CONCLUSION: RET may be considered as a protein marker in CRC detection and prognosis.PMID:33906292 | DOI:10.31557/APJCP.2021.22.4.1019 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Maryam Ashkboos Mehdi Nikbakht Giti Zarinfard Mitra Soleimani Source Type: research

Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1025-1034. doi: 10.31557/APJCP.2021.22.4.1025.ABSTRACTBACKGROUND: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn't satisfactory.METHODS: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed.RESULTS: High Amphiregulin, PTEN and low P21 expre...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Ahmed Ali Obaya Amrallah A Mohammed Hanaa Rashied Adel Mahmoud Morsy Gamal Osman Ahmed S Allam Ahmed M Elsayed Ola A Harb Walid S H Elsayed Source Type: research

Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients
CONCLUSION: SDF-1 dominant model had a higher risk to develop AML, and CXCR4 positive expression predicts poor prognosis in AML patients and it could represent a targeted therapy in AML. In addition, CXCR4 could be easily integrated into the initial routine diagnostic work up of AML..PMID:33906294 | DOI:10.31557/APJCP.2021.22.4.1035 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Doaa Abd Allah M Aladle Mayada A Ghannam Shaimaa El-Ashwah F E I Ghobrial Metwaly Ibrahim Mortada Source Type: research

Utilization of a Mixture Cure Rate Model based on the Generalized Modified Weibull Distribution for the Analysis of Leukemia Patients
CONCLUSION: The results of this study reveal that the EW and the GMW distributions are the best choices for the survival times of Leukemia patients..PMID:33906295 | DOI:10.31557/APJCP.2021.22.4.1045 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mohamed Elamin Omer Mohd Abu Bakar Mohd Adam Mohd Mustafa Source Type: research

Cross-Cultural Adaptation of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in Malaysian Breast Cancer Survivors
CONCLUSION: The Malay version of the FACT-B demonstrated reliable properties and is effective in assessing QOL and can be applied in Malaysian breast cancer survivors.PMID:33906296 | DOI:10.31557/APJCP.2021.22.4.1055 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Khairunnisa' Md Yusof Rozi Mahmud Maha Abdullah Kelly A Avery-Kiejda Rozita Rosli Source Type: research

Analysis of EGFR Mutation Status in Algerian Patients with Non-Small Cell Lung Cancer
CONCLUSION: We found that Algerian NSCLC patients exhibited a high rate of EGFR mutations, which was quite similar to that in Asians population rather than Caucasian patients. Thus, TKI-based treatments may be more beneficial for Algerian patients with NSCLC. Further studies using a large number of patients are required to confirm our preliminary findings.PMID:33906297 | DOI:10.31557/APJCP.2021.22.4.1063 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mohamed Lahmadi Leila Beddar Amira Lyna Rouibah Ali Boumegoura Houda Boufendi Asma Temim Anissa Nini Feriel Sellam Dalila Satta Source Type: research

Establishment of Nude Mice Lacking NK Cells and Their Application for Human Tumor Xenografts
CONCLUSION: Nude-J mice can be a valuable tool for human tumor cell transplantation studies..PMID:33906298 | DOI:10.31557/APJCP.2021.22.4.1069 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Jutatip Panaampon Kenichi Sasamoto Ryusho Kariya Seiji Okada Source Type: research

A Novel Class of Functionalized Synthetic Fluoroquinolones with Dual Antiproliferative - Antimicrobial Capacities
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1075-1086. doi: 10.31557/APJCP.2021.22.4.1075.ABSTRACTAs vosaroxin as a fluoroquinolone (FQ) had anticancer effectiveness; this study aimed to screen new lipophilic FQs for their dual antimicrobial-antiproliferative activities. Using sulforhodamine B assay; 36 lipophilic FQs have been screened for antimicrobial propensities against S. aureus, E. coli, and C. albicans vs. the respective references ciprofloxacin and fluconazole. They were also explored against a battery of cancer cell lines. Normal periodontal ligament fibroblasts (PDL) were tested for safety examination in compariso...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Abdelrahman Al-Nuaimi Yusuf Al-Hiari Violet Kasabri Randa Haddadin Noor Mamdooh Sundus Alalawi Sara Khaleel Source Type: research

Anticancer Activity of Combretum fragrans F. Hoffm on Glioblastoma and Prostate Cancer Cell Lines
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1087-1093. doi: 10.31557/APJCP.2021.22.4.1087.ABSTRACTBACKGROUND: Cancer incidence has been growing in an alarming rate worldwide and new therapeutics are needed, particularly for intractable and chemoresistant cases. We evaluated the cytotoxic effects of Combretum fragrans F. Hoffm (Combretaceae) on glioblastoma (U87MG and C6) and prostate (PC-3) cancer cell lines.METHODS: The cytotoxic effect of the methanolic extract of the stem bark of Combretum fragrans was assessed using XTT (2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide) test. ...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Isaac Silv ère Gade Tagne Simo Richard Corinne Chadeneau Paule Seite Brigitte Vannier Alex De Theodore Atchade Paul F Seke Etet Emmanuel Talla Armel H Nwabo Kamdje Jean-Marc Muller Source Type: research

Antiangiogenic and Proapoptotic Activities of Atorvastatin and Ganoderma lucidum in Tumor Mouse Model via VEGF and Caspase-3 Pathways
Conclusion: Atorvastatin and Ganoderma lucidum may have anticancer, apoptotic and antiangiogenic activities by reducing tumor growth in Ehrlich solid tumor. Their antitumor effect is exerted through the antiangiogenesis effect in tumor cells which is confirmed by the decrease of the angiogenic marker (VEGF protein) as well as by inducing significant increase in the apoptotic protein markers cytochrome-c and caspase-3. It is noticeable that the antitumor activity is ameliorated by the combination of the two treatments.PMID:33906301 | DOI:10.31557/APJCP.2021.22.4.1095 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Iman Hesham El-Khashab Source Type: research

IL-4, IL-17 and CD163 Immunoexpression and IL-6 Gene Polymorphism in Chronic Hepatitis C Patients and Associated Hepatocellular Carcinoma
CONCLUSION: IL-4, IL-17 and CD163 were associated with HCV severity. Their expression in HCC suggests their important role in HCC development. Blocking of these proteins may be a good target to control inflammation in HCV and can hinder progression to cirrhosis then to HCC. On the other hand, IL6-572 promoter gene polymorphism is neither associated with HCV infection nor with HCC development and its progression..PMID:33906302 | DOI:10.31557/APJCP.2021.22.4.1105 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Tarek Aboushousha Marine Emad Gina Rizk Khaled Ragab Olfat Hammam Rabab Fouad Noha Said Helal Source Type: research

Altered Protein and Gene Expression of Beclin-1 Correlates with Poor Prognosis of Hcv-Associated Hepatocellular Carcinoma in Egyptian Patients
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1115-1122. doi: 10.31557/APJCP.2021.22.4.1115.ABSTRACTAutophagy modulation has recently been addressed as a novel target for overcoming therapeutic resistance in hepatocellular carcinoma (HCC) to currently available anti-HCC therapy. The aim of this study was to investigate the protein and gene expression of Beclin-1 and its correlation with prognosis in HCV-associated HCC in Egyptian patients. This prospective study included 50 patients with HCV-associated-HCC, treated with surgical resection. Immunohistochemistry of antibody and quantitative real-time PCR of Beclin-1 gene were as...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Nermine Ahmed Ehsan Asmaa M Mosbeh Sally Waheed Elkhadry Asmaa Ibrahim Gomaa Maha Mohamed Elsabaawy Dina Shehata Elazab Source Type: research

Diagnostic Performance of F-18 FDG PET/CT Compared with CA125, HE4, and ROMA for Epithelial Ovarian Cancer
CONCLUSION: SUVmax using F-18 FDG PET/CT showed a high diagnostic accuracy for differentiating epithelial ovarian cancer from benign pelvic tumors, including early stage ovarian cancer. F-18 FDG PET/CT can be a useful modality for the assessment of pelvic mass..PMID:33906304 | DOI:10.31557/APJCP.2021.22.4.1123 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Sun Seong Lee Ji Sun Park Kyung Bok Lee Dae Hoon Jeong Jung Mi Byun Seok Mo Lee Source Type: research

Diffusion MRI in Evaluation of Pediatric Posterior Fossa Tumors
CONCLUSION: Diffusion MRI has a significant role in diagnosis of pediatric posterior fossa tumors. ADC ratio can be used to distinguish medulloblastoma from other posterior fossa tumor with good level of diagnostic performance.PMID:33906305 | DOI:10.31557/APJCP.2021.22.4.1129 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Warinthorn Phuttharak Mix Wannasarnmetha Sakda Wara-Asawapati Sopiruch Yuthawong Source Type: research

Development of Escherichia coli asparaginase II for the Treatment of Acute Lymphocytic Leukemia: In Silico Reduction of asparaginase II Side Effects by a Novel Mutant (V27F)
This study investigated mutagenesis in Escherichia coli ASNase II to find a mutant with lower GLNase activity via molecular dynamics (MD) simulation. Residues with low binding energy to asparagine (Asn) and high binding energy to glutamine (Gln) were chosen for mutagenesis. A mutant with low free binding energy to Gln was then selected for molecular docking and MD studies. The results showed that V27F is a good candidate for reducing GLNase activity and that it has little effect on enzyme ASNase activity. A simulation analysis showed that the V27F mutant was more stable than the WT ASNase and that mutagenesis was quite suc...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Noeman Ardalan Abbas Akhavan Sepahi Ramazan Ali Khavari-Nejad Source Type: research

Prognostic Impact of the Advanced Lung Cancer Inflammation Index (ALI) in Metastatic Non-Small Cell Lung Cancer Treated with First Line Chemotherapy
The objective of this study was to explore the relationship between ALI and the prognosis of metastatic NSCLC treated with first line chemotherapy.MATERIALS AND METHODS: Data of 109 metastatic NSCLC patients who had completed first line treatment with chemotherapy was collected. A multivariate flexible parametric proportional-hazards model with restricted cubic splines (RCS) was used to explore and identify the independent prognostic factors, including clinical potential factors and ALI for the overall survival. Multivariate regression analysis was used to evaluate the potential prognostic factors associated with short sur...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Chaichana Chantharakhit Nantapa Sujaritvanichpong Source Type: research

Terminalia Catappa Extract (TCE) Reduces Proliferation of Lung and Breast Cancer Cell by Modulating miR-21 and miR-34a Expressions
In this study, the antitumor effect of ethanolic Terminalia catappa leaf extract (TCE) on MCF-7, MDA-231, and A549 cell lines was examined. For this reason, the effects of TCE on cell migration, gene expression, and growth were investigated by scratch, test, real-time PCR (qPCR) qPCR, and MTT tests respectively.RESULTS: As a reported by the MTT outcomes, TCE significantly decreased the viability of A549, MCF-7, and MDA-231 cells (P
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Habib Zarredar Amir Mahdi Khamaneh Fatemeh Firouzi Amoodizaj Dariush Shanaehbandi Ensiyeh Seyedrezazadeh Hamed Sabagh Jadid Milad Asadi Venus Zafari Yeganeh Khalili Zahra Soleimani Atefeh Ansarin Majid Khalili Source Type: research

Breast Cancer Screening in Asian Women with Dense Breast by Mammography: A Cross-Sectional Observational Study
CONCLUSION: After notifying MD, the incidence rate of IC less increased comparing with CDR or PPV. Screening mammography could be more useful to Asian women when reporting MD..PMID:33906309 | DOI:10.31557/APJCP.2021.22.4.1165 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Jung Sun Lee Minkyung Oh Source Type: research

BAX -248 G & gt;A and BCL2 -938 C & gt;A Variant Lowers the Survival in Patients with Nasopharyngeal Carcinoma and Could be Associated with Tissue-Specific Malignancies: A Multi-Method Approach
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1171-1181. doi: 10.31557/APJCP.2021.22.4.1171.ABSTRACTBACKGROUND: The association of BAX -248 G>A and BCL2 -938 C>A with different cancers created conflicts. We studied the correlation and the effect of these polymorphisms in patients with Nasopharyngeal Carcinoma (NPC). Methods: PCR-RFLP and Sanger sequencing were used to detect polymorphisms. Statistical analysis including forest plot and Kaplan-Meier Log-rank test was conducted to investigate the association and effect of these SNPs on the NPC patients' survival. The computational study was performed to investigate the pos...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Koustav Chatterjee Saikat De Sankar Deb Roy Sushil Kumar Sahu Arindom Chakraborty Sandeep Ghatak Nilanjana Das Sudipa Mal Nabanita Roy Chattopadhyay Piyanki Das R Rajendra Reddy Syamantak Mukherjee Ashok Kumar Das Zoreng Puii Eric Zomawia Yengkhom Indibor Source Type: research

The Clinical Value of VDR and CTLA 4 in Evaluating the Prognosis of Invasive Duct Carcinoma of Egyptian Patients and their Benefit as a Target Therapy
CONCLUSION: high VDR expression in tumor cells is associated with good prognostic parameters and is the most independent prognostic factor on overall survival so it might be of benefit as a target therapy for Egyptian invasive duct carcinoma patients and VDR might augment the expression of CTLA-4, So tailored immunotherapy might have an impact on invasive duct carcinoma patients..PMID:33906311 | DOI:10.31557/APJCP.2021.22.4.1183 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Nanis Shawky Holah Source Type: research

Predictive Value of Kozak Gene Polymorphism for Thrombosis in Patients with Philadelphia-Negative MPNs
CONCLUSION: From this study we could conclude that patients with Philadelphia-negative MPNs carried Kozak gene polymorphism significantly TT genotype in all patients PV, ET, MF patients and TC in ET and MF patients. The platelet glycoprotein Ibα (Kozak) gene could be incorporated into the routine workup to predict venous thrombosis in patients with Ph-negative MPNs specially ET patients.PMID:33906312 | DOI:10.31557/APJCP.2021.22.4.1195 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mohammed Sabry El-Ghonemy Shaimaa El-Ashwah May Denewer Eman Adel Soliman Mohammed El-Baiomy Heidi Elkerdawy Ahmed El-Sebaie Source Type: research

Sequence Polymorphism in Xenobiotic Metabolising Genes in Iraqi Colorectal Cancer Patients
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1203-1210. doi: 10.31557/APJCP.2021.22.4.1203.ABSTRACTOBJECTIVES: Colorectal cancer (CRC) is the third most prevalent malignant neoplasm. Genetic variations in the xenobiotic metabolising cytochrome enzymes. Family 1 Subfamily A Member 1 (CYP1A1) and Family 1 Subfamily B Member 1 (CYP1B1) might play a role in cancer pathogenesis and prognosis. The aim of this work is to determine the frequency of Single Nucleotide Polymorphisms (SNPs) in CYP1A1 (rs1048943, Ile462VaI and rs4646903/MSP1) and CYP1B1 (rs1056836, Leu432Val) genes in patients with CRC cancer. It was also an attempt to id...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Salih Q Ibrahem Zana T Al-Dalawi Assma S Bahaaldin Source Type: research

Factors Affecting Survival Outcome After Percutaneous Nephrostomy as Palliative Urinary Diversion in Obstructive Uropathy due to Advance Cervical Cancer Patients
CONCLUSION: The survival after nephrostomy in advanced cervical cancer patients is largely affected by age, metastasis, and performance status. The choices of doing nephrostomy in those patients should be considering those factors to maximize the benefit over the risk of complications..PMID:33906314 | DOI:10.31557/APJCP.2021.22.4.1211 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Bambang Sasongko Noegroho Andri Pratama Kurniawan Zola Wijayanti Akhmad Mustafa Source Type: research

The Impact of Sorafenib in Combination with Transarterial Chemoembolization on the Outcomes of Intermediate-Stage Hepatocellular Carcinoma
CONCLUSIONS: Treatment with sorafenib plus TACE in TACE-refractory patients with intermediate-stage HCC resulted in longer intervals between TACE rounds, better maintenance of hepatic reserve, and significantly longer OS compared with repeated TACE.PMID:33906315 | DOI:10.31557/APJCP.2021.22.4.1217 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Masaki Kaibori Hideyuki Matsushima Morihiko Ishizaki Hisashi Kosaka Kousuke Matsui Shuji Kariya Kengo Yoshii Mitsugu Sekimoto Source Type: research

Comparison of Cervical Levels of Interleukins-6 and -8 in Patients with and without Cervical Intraepithelial Neoplasia
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1225-1230. doi: 10.31557/APJCP.2021.22.4.1225.ABSTRACTINTRODUCTION: Interleukins-6 and -8 are two pro-inflammatory cytokines increasing in serum and local levels under malignant conditions. There are limited evidences on the association between cervical level of these two factors and cervical intraepithelial neoplasia (CIN). So, this study aimed to explore the association between cervical levels of IL-6 and IL-8 with cervical premalignant lesions.METHODS: The present case-control study was conducted on married women undergone Pap smear for routine screening in two groups as the gro...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Zahra Vahedpour Masoumeh Abedzadeh-Kalahroudi Mojtaba Sehat Ahmad Piroozmand Maedeh Memar Source Type: research

Transitional Cancer Care Program from Hospital to Home in the Health Care System of Iran
CONCLUSIONS: It is necessary to revise hospitals' discharge program, and home health care center's plan for admission and delivering health care services for cancer patients. Also, a pilot program is necessary to find the system advantages and disadvantages..PMID:33906317 | DOI:10.31557/APJCP.2021.22.4.1231 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Zahra Alizadeh Camelia Rohani Maryam Rassouli Mahnaz Ilkhani Maryam Hazrati Source Type: research

Association of Righ-Risk Human Papillomavirus and Ureaplasma parvum Co-Infections with Increased Risk of Low-Grade Squamous Intraepithelial Cervical Lesions
CONCLUSION: Our results reinforced the hypothesis that some mycoplasmas may play a role as cofactors in HPV-mediated cervical carcinogenesis, at least in some populations..PMID:33906318 | DOI:10.31557/APJCP.2021.22.4.1239 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Isabella Harumi Yonehara Noma Cristiane Suemi Shinobu-Mesquita Tamy Taianne Suehiro Fabricio Morelli Maria Vit ória Felipe De Souza Edilson Damke V ânia Ramos Sella Da Silva Marcia Edilaine Lopes Consolaro Source Type: research

Using Failure Mode and Effects Analysis in Improving Nursing Blood Sampling at an International Specialized Cancer Center
CONCLUSION: Many factors lead to blood sampling errors. A critical focus should be conducted on the preparation phase due to the possible errors that may occur. Proper identification of patients and blood sample tests are the keys to a significant decrease in blood sampling errors..PMID:33906319 | DOI:10.31557/APJCP.2021.22.4.1247 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Anas Haroun Majeda A Al-Ruzzieh Najah Hussien Abdelrahman Masa'ad Rateb Hassoneh Ghada Abu Alrub Omar Ayaad Source Type: research

Quality of Life after Transcatheter Arterial Chemoembolization Combined with Radiofrequency Ablation in Patients with Unresectable Hepatocellular Carcinoma Compared with Transcatheter Arterial Chemoembolization alone
CONCLUSION: Neither TACE nor TACE-RFA showed a significant decrease in QoL in patients with unresectable HCC two weeks after intervention. However, two months after intervention; TACE-RFA showed significant improvement in global health score compared to TACE monotherapy. TACE-RFA appeared safe, effective and more favorable than TACE monotherapy..PMID:33906320 | DOI:10.31557/APJCP.2021.22.4.1255 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Taha M Hassanin Yasser Fouad Alshymaa Hassnine Mohamad Eisawy Naglaa Farag Wael Abdel Ghany Source Type: research

Epigallocatechin Gallate Enhances Inhibition Effect of DDP on the Proliferation of Gastric Cancer BGC-823 Cells by Regulating p19Arf-p53-p21Cip1 Signaling Pathway
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1263-1270. doi: 10.31557/APJCP.2021.22.4.1263.ABSTRACTOBJECTIVE: To indicate the effect of Epigallocatechin gallate (EGCG) and Cisplatin (DDP) on proliferation of gastric cancer BGC-823 cells and the relative underlying mechanism.METHODS: Cultured BGC-823 cells were treated by 5 μg/mL DDP, 25 μg/mL EGCG and combined 5 μg/mL DDP with 25 μg/mL EGCG, a blank group was used as control. Cell morphology was observed by 4',6-diamidino-2-phenylindole (DAPI) staining. The ability of cell proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mengya Xue XiaoLv Liu Bing Cheng XingKai Rui MingCai Wu Jun Lv Source Type: research

Pap Smear miR-92a-5p and miR-155-5p as potential diagnostic biomarkers of squamous intraepithelial cervical cancer
CONCLUSION: These data suggest miR-92a-5p and miR-155-5p, which are upregulated in LSIL and HSIL, can be consider as predictive biomarkers for the prognosis of cervical cancer patients..PMID:33906322 | DOI:10.31557/APJCP.2021.22.4.1271 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Tahereh Azimi Mahdi Paryan Mahdieh Mondanizadeh Hossein Sarmadian Ashraf Zamani Source Type: research

The Association of Aging-Related Polymorphisms with Susceptibility to Lung Cancer: A Case-Control Study in a Japanese Population
CONCLUSIONS: Our findings indicate that TP53BP1 rs560191 may predispose to lung cancer risk depending on the genotypes of telomere-related polymorphisms. Additional studies are warranted to confirm the findings suggested in the present study..PMID:33906323 | DOI:10.31557/APJCP.2021.22.4.1279 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Hironobu Furuie Masako Arimura-Omori Naoki Hamada Toyoshi Yanagihara Chikako Kiyohara Source Type: research

Evaluation of Successfulness of Capacity Building Programmes on Smokeless Tobacco and Areca Nut Cessation
CONCLUSIONS: Well planned workshops are efficient in improving knowledge, practices and attitudes of dental surgeons towards SLT/AN cessation..PMID:33906324 | DOI:10.31557/APJCP.2021.22.4.1287 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Ruwan Duminda Jayasinghe P R Jayasooriya Hemantha Amarasinghe Pvks Hettiarachchi Bsms Siriwardena Ukygdm Wijerathne S K Kithalawarachchi W M Tilakaratne Source Type: research

New Trends of Cervical Cancer Incidence in Kazakhstan
CONCLUSION: The study of trends of the cervical cancer incidence has the theoretical and practical value: monitoring and evaluation of screening programmes, which are implemented in the country, and conduction of secondary prevention of cervical pathology. Health authorities should consider the obtained results in the in the organization of anti-cancer activities.PMID:33906325 | DOI:10.31557/APJCP.2021.22.4.1295 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Nurbek Igissinov Gulnur Igissinova Zhansaya Telmanova Zarina Bilyalova Dariyana Kulmirzayeva Zhanar Kozhakhmetova Saltanat Urazova Dulat Turebayev Gaukhar Nurtazinova Ardak Omarbekov Aigul Almabayeva Zhanar Bukeyeva Dinara Tarzhanova Altyn Moldabayeva Mar Source Type: research

The Apoptotic Properties of Leaf Extracts of Simarouba glauca against Human Leukemic Cancer Cells
CONCLUSION: These findings suggested that Simarouba glauca leaf extracts inhibited leukemic cells in a time- and dose-dependent manner either through mitochondrial or death receptor activation. The leaf extracts of Simarouba glauca was found to be nontoxic to lymphocytes. It can be concluded that Simarouba glauca is an important source of phytochemicals posing efficacy against leukemic cancer cells..PMID:33906326 | DOI:10.31557/APJCP.2021.22.4.1305 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Vikas Biba Sujathan Kunjiraman Suja Somasekharan Nair Rajam Sukumaran Anil Source Type: research

Comparative Analysis of Vaginal Microbiota in Women with Breast Cancer in Kazakhstan
CONCLUSION: The observed features of the vaginal microbiota in women with different subtypes of breast cancer require further studies for preventive purposes..PMID:33906327 | DOI:10.31557/APJCP.2021.22.4.1313 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Farida K Balmaganbetova Ainur Amanzholkyzy Roza E Nurgaliyeva Aiman T Kaldybayeva Azhar N Zhexenova Source Type: research

Genetic Association of CYP1B1 4326 C & gt;G Polymorphism with Disease-Free Survival in TNBC Patients Undergoing TAC Chemotherapy Regimen
CONCLUSION: Our results demonstrate the potential use of CYP1B1 4325 GG variant genotype as a candidate biomarker in predicting risk of recurrence in TNBC patients undergoing TAC chemotherapy regimen.PMID:33906328 | DOI:10.31557/APJCP.2021.22.4.1319 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Ahmad Aizat Abdul Aziz Md Salzihan Md Salleh Maya Mazuwin Yahya Andee Dzulkarnaen Zakaria Ravindran Ankathil Source Type: research

Outcomes of Laparoscopic Versus Open Surgery in Elderly Patients with Rectal Cancer
CONCLUSIONS: Laparoscopic rectal surgery is safe and feasible in patients aged≥80 y and is associated with similar long-term oncologic outcomes when compared with open surgery. .PMID:33906329 | DOI:10.31557/APJCP.2021.22.4.1325 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Qi Zhang Jianwei Liang Jianan Chen Shiwen Mei Zheng Wang Source Type: research

Effect of Vitamin D Deficiency on Liver Cancer Risk: A Systematic Review and Meta-Analysis
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):991-997. doi: 10.31557/APJCP.2021.22.4.991.ABSTRACTEpidemiological studies have showed that vitamin D deficiency can increase the risk of liver cancers. Hence, we conducted a meta-analysis to explore the relationship between 25-hydroxyvitamin D [25(OH)D] levels and liver cancer risk.METHODS: Cochrane Library, Medline, Web of Science, and Embase were searched up to Mar. 2020, and the references of those studies were also searched by hand. A meta-analysis of 11 studies was performed which met the inclusion criteria. Six case-control studies and five cohort studies were included.RESUL...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Zhenghui Yi Linjie Wang Xiangqun Tu Source Type: research

Role of microRNAs in Predicting the Prognosis of Cervical Cancer Cases: A Systematic Review and Meta-Analysis
CONCLUSION: The downregulation of aberrant miRNAs was not associated with poor overall survival rates.PMID:33906290 | DOI:10.31557/APJCP.2021.22.4.999 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Sasidharanpillai Sabeena Nagaraja Ravishankar Source Type: research

Determinants of Delayed Presentation and Advanced-Stage Diagnosis of Breast Cancer in Africa: A Systematic Review and Meta-Analysis
CONCLUSION: Promoting early presentation and reducing advanced-stage BC throughout Africa should focus on modifiable factors, including providing quality education, improving breast health awareness and BC knowledge, and developing strategies to increase BSE and CBE. Interventions targeting socio-demographic determinants should be context-specific.PMID:33906291 | DOI:10.31557/APJCP.2021.22.4.1007 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Olayide Agodirin Isiaka Aremu Ganiyu Rahman Samuel Olatoke Julius Olaogun Halimat Akande Anya Romanoff Source Type: research

RET Protein Expression in Colorectal Cancer; An Immunohistochemical Assessment
CONCLUSION: RET may be considered as a protein marker in CRC detection and prognosis.PMID:33906292 | DOI:10.31557/APJCP.2021.22.4.1019 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Maryam Ashkboos Mehdi Nikbakht Giti Zarinfard Mitra Soleimani Source Type: research

Evaluating the value of Amphiregulin, Phosphatase and Tensin Homologue (PTEN) and P21 Expression for Anti-EGFR Treatment in Metastatic Colorectal Carcinoma
Asian Pac J Cancer Prev. 2021 Apr 1;22(4):1025-1034. doi: 10.31557/APJCP.2021.22.4.1025.ABSTRACTBACKGROUND: Despite the significant progress in target therapy for the treatment of metastatic colorectal carcinoma (mCRC), the overall survival isn't satisfactory.METHODS: We assessed the expression of Amphiregulin, PTEN, and P21 in sections from 23 paraffin blocks prepared from 23 patients with left-sided mCRC using immunohistochemistry (IHC). The relationship between their level of expressions, clinicopathological parameters, response to anti-EGFR, and prognosis were analyzed.RESULTS: High Amphiregulin, PTEN and low P21 expre...
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Ahmed Ali Obaya Amrallah A Mohammed Hanaa Rashied Adel Mahmoud Morsy Gamal Osman Ahmed S Allam Ahmed M Elsayed Ola A Harb Walid S H Elsayed Source Type: research

Association of SDF-1 Gene Polymorphism with Increased Risk of Acute Myeloid Leukemia Patients
CONCLUSION: SDF-1 dominant model had a higher risk to develop AML, and CXCR4 positive expression predicts poor prognosis in AML patients and it could represent a targeted therapy in AML. In addition, CXCR4 could be easily integrated into the initial routine diagnostic work up of AML..PMID:33906294 | DOI:10.31557/APJCP.2021.22.4.1035 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Doaa Abd Allah M Aladle Mayada A Ghannam Shaimaa El-Ashwah F E I Ghobrial Metwaly Ibrahim Mortada Source Type: research

Utilization of a Mixture Cure Rate Model based on the Generalized Modified Weibull Distribution for the Analysis of Leukemia Patients
CONCLUSION: The results of this study reveal that the EW and the GMW distributions are the best choices for the survival times of Leukemia patients..PMID:33906295 | DOI:10.31557/APJCP.2021.22.4.1045 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mohamed Elamin Omer Mohd Abu Bakar Mohd Adam Mohd Mustafa Source Type: research

Cross-Cultural Adaptation of the Functional Assessment of Cancer Therapy-Breast (FACT-B) in Malaysian Breast Cancer Survivors
CONCLUSION: The Malay version of the FACT-B demonstrated reliable properties and is effective in assessing QOL and can be applied in Malaysian breast cancer survivors.PMID:33906296 | DOI:10.31557/APJCP.2021.22.4.1055 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Khairunnisa' Md Yusof Rozi Mahmud Maha Abdullah Kelly A Avery-Kiejda Rozita Rosli Source Type: research

Analysis of EGFR Mutation Status in Algerian Patients with Non-Small Cell Lung Cancer
CONCLUSION: We found that Algerian NSCLC patients exhibited a high rate of EGFR mutations, which was quite similar to that in Asians population rather than Caucasian patients. Thus, TKI-based treatments may be more beneficial for Algerian patients with NSCLC. Further studies using a large number of patients are required to confirm our preliminary findings.PMID:33906297 | DOI:10.31557/APJCP.2021.22.4.1063 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 28, 2021 Category: Cancer & Oncology Authors: Mohamed Lahmadi Leila Beddar Amira Lyna Rouibah Ali Boumegoura Houda Boufendi Asma Temim Anissa Nini Feriel Sellam Dalila Satta Source Type: research