Sequencing considerations in the third-line treatment of metastatic colorectal cancer
Am J Manag Care. 2024 May;30(2 Suppl):S31-S35. doi: 10.37765/ajmc.2024.89546.ABSTRACTNumerous advances in the standard of care for metastatic colorectal cancer (mCRC), including the approval of several new treatments indicated for treatment in the third line or later (3L+), have been made, yet data and appropriate guidance on the optimal sequencing and treatment strategies for these lines of therapy are lacking. Four treatments-regorafenib, trifluridine/tipiracil alone or with bevacizumab, and fruquintinib-are FDA-approved and recommended by the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for the trea...
Source: The American Journal of Managed Care - May 3, 2024 Category: Health Management Authors: Afsaneh Barzi Tanios Bekaii-Saab Source Type: research
A decade of progress: advances in the third-line treatment of patients with metastatic colorectal cancer
Am J Manag Care. 2024 May;30(2 Suppl):S23-S30. doi: 10.37765/ajmc.2024.89545.ABSTRACTThe treatment of metastatic colorectal cancer (mCRC) remains challenging. There has been substantial progress in understanding the molecular pathology of the disease that has led to meaningful advancements in treatment options with varying mechanisms of action, although treatment remains costly. Cytotoxic therapies, which are typically combined with targeted therapies, remain the mainstay of first- and second-line treatment for mCRC. While also relevant in earlier lines of therapy, molecular testing has become increasingly important to gui...
Source: The American Journal of Managed Care - May 3, 2024 Category: Health Management Authors: Tanios Bekaii-Saab Source Type: research
Detailed analysis of metastatic colorectal cancer patients who developed cardiotoxicity on another fluoropyrimidine and switched to S-1 treatment (subgroup analysis of the CardioSwitch-study)
Acta Oncol. 2024 May 2;63:248-258. doi: 10.2340/1651-226X.2024.24023.ABSTRACTBACKGROUND AND PURPOSE: The CardioSwitch-study demonstrated that patients with solid tumors who develop cardiotoxicity on capecitabine or 5-fluorouracil (5-FU) treatment can be safely switched to S-1, an alternative fluoropyrimidine (FP). In light of the European Medicines Agency approval of S-1 in metastatic colorectal cancer (mCRC), this analysis provides more detailed safety and efficacy information, and data regarding metastasectomy and/or local ablative therapy (LAT), on the mCRC patients from the original study.MATERIALS AND METHODS: This re...
Source: Acta Oncologica - May 3, 2024 Category: Cancer & Oncology Authors: Sampsa Kinos Helga Hagman P äivi Halonen Leena-Maija Soveri Mary O'Reilly Per Pfeiffer Jan-Erik Fr ödin Halfdan Sorbye Eetu Heerv ä Gabor Liposits Raija Kallio Annika Ålgars Raija Ristam äki Tapio Salminen Maarit B ärlund Carl-Henrik Shah Ray McDerm Source Type: research
Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network
CONCLUSIONS: A highly accurate CNN matched the performance of colorectal surgeons in identifying a noncomplete response to TNT. However, the model demonstrated suboptimal accuracy when analyzing images of local regrowth.PMID:38700799 | DOI:10.1245/s10434-024-15311-y (Source: Ann Oncol)
Source: Ann Oncol - May 3, 2024 Category: Cancer & Oncology Authors: Hannah Williams Hannah M Thompson Christina Lee Aneesh Rangnekar Jorge T Gomez Maria Widmar Iris H Wei Emmanouil P Pappou Garrett M Nash Martin R Weiser Philip B Paty J Joshua Smith Harini Veeraraghavan Julio Garcia-Aguilar Source Type: research
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials
CONCLUSIONS: Our study suggests that GLP1RA may decrease the risk of breast cancer and basal cell carcinoma, but increase the risk of colorectal cancer. However, according to the systematic review of RCTs, the incidence of cancer in patients treated with GLP1RA is low. Larger sample sizes of RCTs with long-term follow-up are necessary to establish the incidence of cancers and evaluate the risk-benefit ratios.PMID:38701500 | DOI:10.1097/JS9.0000000000001514 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Yuming Sun Yongjia Liu Yating Dian Furong Zeng Guangtong Deng Shaorong Lei Source Type: research
Remote ischemic preconditioning versus sham-control for prevention of anastomotic leakage after resection for rectal cancer (RIPAL trial): a pilot randomized controlled, triple-blinded monocenter trial
CONCLUSION: A clinically relevant protective effect of RIPC on anastomotic healing after rectal resection cannot be assumed on the basis of these data.PMID:38700747 | DOI:10.1007/s00384-024-04637-4 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Julia Hardt Steffen Seyfried Hannah Brodrecht Leila Khalil Sylvia B üttner Florian Herrle Christoph Reissfelder Nuh N Rahbari Source Type: research
Pharmacological effects of ginseng and ginsenosides on intestinal inflammation and the immune system
Front Immunol. 2024 Apr 18;15:1353614. doi: 10.3389/fimmu.2024.1353614. eCollection 2024.ABSTRACTIntestinal inflammatory imbalance and immune dysfunction may lead to a spectrum of intestinal diseases, such as inflammatory bowel disease (IBD) and gastrointestinal tumors. As the king of herbs, ginseng has exerted a wide range of pharmacological effects in various diseases. Especially, it has been shown that ginseng and ginsenosides have strong immunomodulatory and anti-inflammatory abilities in intestinal system. In this review, we summarized how ginseng and various extracts influence intestinal inflammation and immune funct...
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Linxian Zhao Tongbo Zhang Kai Zhang Source Type: research
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
CONCLUSION: TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.PMID:38699653 | PMC:PMC11063473 | DOI:10.2147/CMAR.S447549 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Ahmet Bozdag Tuncay Kuloglu Gokhan Artas Suleyman Aydin Source Type: research
Impact of the Affordable Care Act on access to accredited facilities for cancer treatment
CONCLUSIONS: Our findings suggest that insurance expansions under the ACA were associated with increased access to NCI-CCCs.PMID:38698670 | DOI:10.1111/1475-6773.14315 (Source: Cancer Control)
Source: Cancer Control - May 3, 2024 Category: Cancer & Oncology Authors: Lindsay M Sabik Youngmin Kwon Coleman Drake Jonathan Yabes Manisha Bhattacharya Zhaojun Sun Cathy J Bradley Bruce L Jacobs Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients
CONCLUSION: Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondrial dysfunction.PMID:38699382 | PMC:PMC11062027 | DOI:10.1093/pcmedi/pbae008 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Andrei Kudriavtsev Brice Pastor Alexia Mirandola Ekaterina Pisareva Yann Gricourt Xavier Capdevila Alain R Thierry Philippe Cuvillon Source Type: research
Yogurt Prevents Colorectal Tumorigenesis in Apc < sup > Min/+ < /sup > Mice
CONCLUSION: Yogurt protects against intestinal polyposis in ApcMin/+ mice, and d-Lac may partially account for the chemopreventive effects above.PMID:38700077 | DOI:10.1002/mnfr.202300737 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Xiaojing Li Jin Qian Qinglong Liu Min Guo Hao Zhang Haitao Li Wei Chen Source Type: research
Curcumin and its anti-colorectal cancer potential: From mechanisms of action to autophagy
Phytother Res. 2024 May 3. doi: 10.1002/ptr.8220. Online ahead of print.ABSTRACTColorectal cancer (CRC) development and progression, one of the most common cancers globally, is supported by specific mechanisms to escape cell death despite chemotherapy, including cellular autophagy. Autophagy is an evolutionarily highly conserved degradation pathway involved in a variety of cellular processes, such as the maintenance of cellular homeostasis and clearance of foreign bodies, and its imbalance is associated with many diseases. However, the role of autophagy in CRC progression remains controversial, as it has a dual function, a...
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Aranka Brockmueller Vicen ç Ruiz de Porras Mehdi Shakibaei Source Type: research
Investigation of Trpa1 and Trpc1 Immunreactivities in Colon Adenocarcinomas
CONCLUSION: TRPA1 and TRPC1 immunoreactivites are increased in colorectal adenocarcinoma tissue compared with the healthy tissue. Furthermore, the immunoreactivity decreases as the grade of cancer increases.PMID:38699653 | PMC:PMC11063473 | DOI:10.2147/CMAR.S447549 (Source: Cell Research)
Source: Cell Research - May 3, 2024 Category: Cytology Authors: Ahmet Bozdag Tuncay Kuloglu Gokhan Artas Suleyman Aydin Source Type: research
