Circulating-tumour DNA methylation of HAND1 gene: a promising biomarker in early detection of colorectal cancer
Colorectal cancer (CRC) is one of the significant global health concerns with an increase in cases. Regular screening tests are crucial for early detection as it is often asymptomatic in the initial stages. Li... (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - April 30, 2024 Category: Genetics & Stem Cells Authors: Mehrdad Shavali, Arash Moradi, Mohammad Tahmaseb, Kamal Mohammadian and Shahla Mohammad Ganji Tags: Research Source Type: research
The utility of synoptic operation reports in colorectal surgery: a systematic review
ConclusionsSR offer advantages in completeness, data extraction, and communication compared to NR. Surgeons perceive them as beneficial for research, quality improvement, and teaching. This review supports the necessity for development of user-friendly SR that seamlessly integrate into pre-existing EMRs, optimising patient care and enhancing the quality of CRC surgical documentation. (Source: International Journal of Colorectal Disease)
Source: International Journal of Colorectal Disease - April 30, 2024 Category: Gastroenterology Source Type: research
Cancers, Vol. 16, Pages 1756: Interventional Treatments of Colorectal Liver Metastases Using Thermal Ablation and Transarterial Chemoembolization: A Single-Center Experience over 26 Years
li
Hamzah Adwan
The aim of this study was to analyze the long-term results of different locoregional treatments for colorectal cancer liver metastases (CRLM), including transarterial chemoembolization (TACE), laser-induced thermotherapy (LITT) and microwave ablation (MWA). A total of 2140 patients with CRLM treated at our department between 1993 and 2020 were included in this retrospective study. The patients were divided into the following groups: LITT (573 patients; median age: 62 years), TACE + LITT (346 patients; median age: 62 years), MWA (67 patients; median age: 59 years), TACE + MWA (152 patients; median age:...
Source: Cancers - April 30, 2024 Category: Cancer & Oncology Authors: Thomas J. Vogl Jason Freichel Tatjana Gruber-Rouh Nour-Eldin Abdelrehim Nour-Eldin Wolf-Otto Bechstein Stefan Zeuzem Nagy N. N. Naguib Ulrich Stefenelli Hamzah Adwan Tags: Article Source Type: research
Principles of risk assessment in colon cancer: immunity is key
Volume 13, Issue 1, December 2024 . (Source: OncoImmunology)
Source: OncoImmunology - April 30, 2024 Category: Cancer & Oncology Authors: Assia HijaziJ érôme Galona INSERM, Laboratory of Integrative Cancer Immunology, Paris, Franceb Equipe Labellisée Ligue Contre le Cancer, Paris, Francec Centre de Recherche des Cordeliers, Sorbonne Université, Université Paris Cité, Paris, Franced Ve Source Type: research
A comprehensive characterization of the spectrum of MUTYH germline pathogenic variants in Latin America
We reported a high frequency of European founder variants in our diverse population. Some phenotypic differences from current studies were identified, such as a higher breast cancer burden in monoallelic carriers and a complete absence of extra-colon tumors in biallelic patients. (Source: Familial Cancer)
Source: Familial Cancer - April 30, 2024 Category: Cancer & Oncology Source Type: research
Strategies for diagnosis and management of CMMRD in low-resource countries: report of a Tunisian family
This study describes a patient diagnosed with colorectal cancer and grade 3 astrocytoma at the age of 11 and 12 respectively. Immunohistochemistry analysis showed a loss of MSH2 and MSH6 protein expression in CRC tissues of the patient. We identified by Targeted Exome Sequencing a homozygous pathogenic germline variant in exon 9 of theMSH6 gene (c.3991 C > T; p.Ala1268Glyfs*6). Genetic investigation of the family showed that the father was heterozygous for the identified pathogenic variant while the brother was wild type for this variant. Our study highlights the importance of a correct and timely diagnosis of CM...
Source: Familial Cancer - April 30, 2024 Category: Cancer & Oncology Source Type: research
A Randomized Trial of Choice Architecture and Mailed Colorectal Cancer Screening Outreach in a Community Health Setting
Mailed outreach for CRC screening increases uptake but it is unclear how to offer the choice of testing. We evaluated if the active choice between colonoscopy and fecal immunochemical test (FIT), or FIT alone, increased response compared to colonoscopy alone. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 30, 2024 Category: Gastroenterology Authors: Shivan J. Mehta, Sanjay Palat, Caitlin McDonald, Catherine Reitz, Evelyn Okorie, Keyirah Williams, Jinming Tao, Pamela A. Shaw, Karen Glanz, David A. Asch Source Type: research
Genes, Vol. 15, Pages 577: Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes
ynski
P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), head and neck squamou...
Source: Genes - April 30, 2024 Category: Genetics & Stem Cells Authors: Ruby Khan Bakht Pari Krzysztof Puszynski Tags: Article Source Type: research
NestedBD: Bayesian inference of phylogenetic trees from single-cell copy number profiles under a birth-death model
Algorithms Mol Biol. 2024 Apr 29;19(1):18. doi: 10.1186/s13015-024-00264-4.ABSTRACTCopy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been available via "bulk sequencing," the more recently introduced techniques for single-cell DNA sequencing (scDNAseq) provide the type of data that makes CNA inference possible at the single-cell resolution. We introduce a new birth-death evolutionary model of CNAs and a Bayesian method, NestedBD, for the inf...
Source: Algorithms for Molecular Biology : AMB - April 29, 2024 Category: Molecular Biology Authors: Yushu Liu Mohammadamin Edrisi Zhi Yan Huw A Ogilvie Luay Nakhleh Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
Investigating the therapeutic potential of < em > Bifidobacterium breve < /em > and < em > Lactobacillus rhamnosus < /em > postbiotics through apoptosis induction in colorectal HT-29 cancer cells
CONCLUSION: Our research suggests that postbiotic metabolites may be effective biological products for the prevention and treatment of cancer.PMID:38682058 | PMC:PMC11055435 | DOI:10.18502/ijm.v16i1.14873 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Nafiseh Erfanian Hossein Safarpour Tahmineh Tavakoli Mohammad Ali Mahdiabadi Saeed Nasseri Mohammad Hassan Namaei Source Type: research
Synergistic effects of < em > Bacillus coagulans < /em > and < em > Newcastle disease virus < /em > on human colorectal adenocarcinoma cell proliferation
CONCLUSION: It appears that utilizing oncolytic viruses (OV) and bacteria in conjunction with chemotherapy drugs could potentially aid in reducing the growth of colorectal cancer cells. However, further research is necessary, including animal studies, to confirm the efficacy of this treatment method.PMID:38682055 | PMC:PMC11055439 | DOI:10.18502/ijm.v16i1.14878 (Source: Iranian Journal of Microbiology)
Source: Iranian Journal of Microbiology - April 29, 2024 Category: Microbiology Authors: Hadi Esmaeili Gouvarchinghaleh Cyrus Jalili Maryam Zamir Nasta Fatemeh Mokhles Elmira Afrasiab Farhad Babaei Source Type: research
Correlation between Pain and Anal Defecation Function in Postoperative Patients with Colorectal Cancer and Related Factors Affecting Patients' Prognosis
CONCLUSION: LARS is strongly associated with the patient's pain level, and factors such as anastomotic position <5 cm from the anal verge, preoperative radiotherapy, anastomotic fistula, high VAS level, and low MTV level will increase the risk of concurrent LARS in patients.PMID:38684502 | DOI:10.62713/aic.3173 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Yuanwei Zhang Chengjiang Xiang Jinhao Liang Source Type: research
Implications of Pretreatment Serum Carcinoembryonic Antigen Levels and Perineural Invasion with Staging, Prognosis, and Management in Stage I-III Colon Cancer after Surgery: A Retrospective Cohort Study in the SEER Database
CONCLUSION: For postoperative patients with stage I-III colon cancer, our study indicated that the CP stage is a significant prognostic factor for CSS, which deserves more clinical attention. It's worth noting that including the CP stage in the AJCC TNM staging system of colon carcinoma is beneficial to the survival prediction and clinical treatment.PMID:38684496 | DOI:10.62713/aic.3296 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - April 29, 2024 Category: Surgery Authors: Qing Zhang Li Wang Ruirui Sun Jian Gao Tingting Liu Source Type: research
Evaluation of the Combined Effect of Caffeine and 5-Fluorouracil on Colorectal Cancer Cell Lines
In this study, initially HCT116 and HEK293 cell lines were cultured as cancer and normal cells, respectively. These cell lines were then evaluated for cytotoxicity, induction of apoptosis, and rate of cell migration. All data were analyzed by statistical methods.RESULTS: The results indicated that a combination of caffeine and 5-FU augmented their cytotoxicity in HCT116 cells but reduced cytotoxicity in HEK293 cells. No reduction was observed in the migration of HCT116 cells that were treated with caffeine or a combination of caffeine and 5-FU. Also, it seems that caffeine reverses the apoptotic effect of 5-FU in HCT116 ce...
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Fatemeh Khavari Mohammad Taheri Hamed Manoochehri Pejman Molaei Fatemeh Nouri Source Type: research
