MAPKAP1 orchestrates macrophage polarization and lipid metabolism in fatty liver-enhanced colorectal cancer
This study explores the mechanistic role of fatty liver in CRC progression, focusing on macrophage polarization and lipid metabolism. A murine fatty liver model was created with a high-fat diet (HFD), and CRC was induced using AOM and DSS. Single-cell transcriptome sequencing (scRNA-seq) identified MAPKAP1 as a critical gene promoting CRC via M2 macrophage polarization and lipid metabolism reprogramming. Prognosis analysis on the TCGA-CRC dataset confirmed MAPKAP1's significance. In vitro and in vivo experiments demonstrated that EVs from fatty liver cells enhanced MAPKAP1 expression, accelerating CRC development and metas...
Source: Translational Oncology - May 1, 2024 Category: Cancer & Oncology Authors: Bo Huang Zhenqiu Yu Dejun Cui Fawang Du Source Type: research
Correction: Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/ GPX4 expression
J Exp Clin Cancer Res. 2024 May 2;43(1):131. doi: 10.1186/s13046-024-03051-6.NO ABSTRACTPMID:38693552 | DOI:10.1186/s13046-024-03051-6 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Yaya Qiao Meng Su Huifang Zhao Huanle Liu Chenxi Wang Xintong Dai Lingling Liu Guangju Liu Huanran Sun Mingming Sun Jiyan Wang Zhen Li Jun Fan Quan Zhang Chunshen Li Fangmin Situ Jun Xue Zhenghu Jia Chunze Zhang Shuai Zhang Changliang Shan Source Type: research
Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Cell Research)
Source: Cell Research - May 1, 2024 Category: Cytology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Research on the Effect and Mechanism of Selenium on Colorectal Cancer Through TRIM32
In conclusion, our findings provided evidence that Se inhibited the growth of colorectal cancer cells by down-regulating TRIM32.PMID:38691306 | DOI:10.1007/s12011-024-04206-4 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - May 1, 2024 Category: Biology Authors: Xiaohua Cai Yintong Su Jiayu Ning Xingxing Fan Mei Shen Source Type: research
Mechanism of bufalin inhibition of colon cancer liver metastasis by regulating M2-type polarization of Kupffer cells induced by highly metastatic colon cancer cells
AbstractPatients with metastatic colorectal cancer often have poor outcomes, primarily due to hepatic metastasis. Colorectal cancer (CRC) cells have the ability to secrete cytokines and other molecules that can remodel the tumor microenvironment, facilitating the spread of cancer to the liver. Kupffer cells (KCs), which are macrophages in the liver, can be polarized to M2 type, thereby promoting the expression of adhesion molecules that aid in tumor metastasis. Our research has shown that huachanshu (with bufalin as the main active monomer) can effectively inhibit CRC metastasis. However, the underlying mechanism still nee...
Source: Apoptosis - May 1, 2024 Category: Molecular Biology Source Type: research
Real-World Evidence of FOLFIRI Combined with Anti-Angiogenesis Inhibitors or Anti-EGFR Antibodies for Patients with Early Recurrence Colorectal Cancer After Adjuvant FOLFOX/CAPOX Therapy: A Japanese Claims Database Study
ConclusionsThis is the first administrative data-based real-world evidence on treatment sequence and outcomes for patients with early recurrence CRC treated with FOLFIRI+AAs or FOLFIRI+ anti-EGFR antibodies after adjuvant FOLFOX/CAPOX therapy in Japan. Both regimens had similar TTD, but relapse timing and tumor sidedness may influence their efficacy. (Source: Targeted Oncology)
Source: Targeted Oncology - May 1, 2024 Category: Cancer & Oncology Source Type: research
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis
British Journal of Cancer, Published online: 01 May 2024; doi:10.1038/s41416-024-02699-3Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Luke B. Villareal Daniel M. Falcon Liwei Xie Xiang Xue Source Type: research
Cancers, Vol. 16, Pages 1765: Geographical Variations in Early Onset Colorectal Cancer in the United States between 2001 and 2020
Discussion: Our analysis of nationwide US data spanning two decades and encompassing over half a million early-onset CRC patients, representing nearly 98% of the US population, highlights significant temporal variation in incidence rates across various geographical regions. The most substantial increases in incidence rates were observed in the west, while the least pronounced changes were noted in the south, affecting both men and women. These trends persisted across the main CRC histopathological subtypes, with NET exhibiting a notably swifter pace of increase compared with ADC. These findings hold important implications ...
Source: Cancers - May 1, 2024 Category: Cancer & Oncology Authors: Yazan Abboud Madison Fraser Imran Qureshi Shivani Srivastava Ibrahim Abboud Benjamin Richter Fouad Jaber Saqr Alsakarneh Ahmed Al-Khazraji Kaveh Hajifathalian Tags: Article Source Type: research
Overexpressing Bcl-2 enhances murine chimeric antigen receptor T cell therapy against solid tumor
AbstractChimeric antigen receptor T (CART) cell therapy has demonstrated promising potential in the treatment of hematologic malignancies. However, its application to solid tumors is limited due to the restrictive nature of the tumor microenvironment, resulting in functional failure and poor persistence of CART cells. Overexpression of Bcl-2 in human CART cells (hCART) has been found to significantly enhance their anti-apoptotic effects both in vitro and in vivo. Nevertheless, the evaluation of hCART cells in preclinical studies has predominantly relied on immunodeficient mice xenograft tumor models, making it challenging ...
Source: Human Cell - May 1, 2024 Category: Cytology Source Type: research
Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies
Cell Death & Disease, Published online: 01 May 2024; doi:10.1038/s41419-024-06690-xImpact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies (Source: Cell death and disease)
Source: Cell death and disease - May 1, 2024 Category: Internal Medicine Authors: Maria Virginia Giolito Serguei Bodoirat Theo La Rosa Mathieu Reslinger Gabriela D. A. Guardia Jana Mourtada Leo Claret Alain Joung Pedro A. F. Galante Luiz O. F. Penalva Michelina Plateroti Source Type: research
Preclinical Characterization of DPI-4452: A 68Ga/177Lu Theranostic Ligand for Carbonic Anhydrase IX
Conclusion: DPI-4452 selectively targets CAIX. [68Ga]Ga-DPI-4452 and [177Lu]Lu-DPI-4452 localized to tumors and were well tolerated in mice. [177Lu]Lu-DPI-4452 demonstrated strong tumor growth inhibition in 2 xenograft mouse models. Thus, the 2 agents potentially provide a theranostic approach for selecting and treating patients with CAIX-expressing tumors such as ccRCC, CRC, and pancreatic ductal adenocarcinoma. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 1, 2024 Category: Nuclear Medicine Authors: Massiere, F., Wiedemann, N., Borrego, I., Hoehne, A., Osterkamp, F., Paschke, M., Zboralski, D., Schumann, A., Bredenbeck, A., Brichory, F., Attinger, A. Tags: Basic Science Investigations Source Type: research
Estimated impact and value of blood-based colorectal cancer screening at varied adherence compared with stool-based screening
Conclusions: Triennial screening with mt-sDNA resulted in better clinical outcomes at a lower cost compared with the modeled blood-based test even at perfect adherence, supporting application of blood-based tests only as a secondary screening option.PMID:38686394 | DOI:10.1080/13696998.2024.2349467 (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - April 30, 2024 Category: Health Management Authors: John B Kisiel A Mark Fendrick Derek W Ebner A Burak Ozbay Vahab Vahdat Chris Estes Paul J Limburg Source Type: research
