New-Generation Fetal Dose Estimates for Radiopharmaceuticals
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Stabin, M. G. Tags: Radiobiology/Dosimetry Source Type: research

Reproducibility of MR-Based Attenuation Maps in PET/MRI and the Impact on PET Quantification in Lung Cancer
Conclusion: Artifacts occur frequently in standard thoracic MR-AC maps, affecting the reproducibility of PET/MRI. These, in combination with other well-known sources of error associated with PET/MRI examinations, lead to inconsistent SUV measurements in serial studies, which may affect the reliability of therapy response assessment. A thorough visual inspection of the thoracic MR-AC map and Dixon images from which it is derived remains crucial for the detection of MR-AC artifacts that may influence the reliability of SUV. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Olin, A., Ladefoged, C. N., Langer, N. H., Keller, S. H., Lofgren, J., Hansen, A. E., Kjaer, A., Langer, S. W., Fischer, B. M., Andersen, F. L. Tags: Physics and Instrumentation Source Type: research

Development and Evaluation of mini-EXPLORER: A Long Axial Field-of-View PET Scanner for Nonhuman Primate Imaging
Conclusion: This study demonstrated the physical performance and imaging capabilities of a long axial FOV PET scanner designed for high-sensitivity imaging of nonhuman primates. Further, the results of this study suggest that a wide acceptance angle can be used with a long axial FOV scanner to maximize sensitivity while introducing only minor trade-offs such as a small increase in scatter fraction and slightly degraded axial spatial resolution. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Berg, E., Zhang, X., Bec, J., Judenhofer, M. S., Patel, B., Peng, Q., Kapusta, M., Schmand, M., Casey, M. E., Tarantal, A. F., Qi, J., Badawi, R. D., Cherry, S. R. Tags: Physics and Instrumentation Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: Erratum Source Type: research

Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer
Conclusion: These findings underline that variations in the polymethine chain lengths of cyanine dyes have a profound influence on the photophysical properties, stability, and in vivo targeting capabilities of fluorescent imaging tracers. In a direct comparison, the intermediate-length dye (Cy5) yielded a superior c[RGDyK] tracer, compared with the shorter (Cy3) and longer (Cy7) analogs. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Buckle, T., van Willigen, D. M., Spa, S. J., Hensbergen, A. W., van der Wal, S., de Korne, C. M., Welling, M. M., van der Poel, H. G., Hardwick, J. C. H., van Leeuwen, F. W. B. Tags: Basic Source Type: research

Immuno-PET in Inflammatory Bowel Disease: Imaging CD4-Positive T Cells in a Murine Model of Colitis
Conclusion: 89Zr-malDFO-GK1.5 cDb detected CD4+ T cells in the colons, ceca, and MLNs of colitic mice and may prove useful for further investigations of CD4+ T cells in preclinical models of IBD, with potential to guide development of antibody-based imaging in human IBD. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Freise, A. C., Zettlitz, K. A., Salazar, F. B., Tavare, R., Tsai, W.-T. K., Chatziioannou, A. F., Rozengurt, N., Braun, J., Wu, A. M. Tags: Basic Source Type: research

Molecular Imaging of ABCB1 and ABCG2 Inhibition at the Human Blood-Brain Barrier Using Elacridar and 11C-Erlotinib PET
Conclusion: When Abcb1 and Abcg2 were disrupted in mice, brain uptake of 11C-erlotinib increased both at a tracer dose and at a pharmacologic dose. In patients, brain uptake of 11C-erlotinib was not higher after administration of elacridar. The more pronounced role that ABCG2 appears to play at the human blood–brain barrier and the lower potency of elacridar to inhibit ABCG2 may be an explanation of these interspecies differences. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Verheijen, R. B., Yaqub, M., Sawicki, E., van Tellingen, O., Lammertsma, A. A., Nuijen, B., Schellens, J. H. M., Beijnen, J. H., Huitema, A. D. R., Hendrikse, N. H., Steeghs, N. Tags: Clinical Source Type: research

18F-FDG PET/MRI in Chronic Sciatica: Early Results Revealing Spinal and Nonspinal Abnormalities
Conclusion: The feasibility of 18F-FDG PET/MRI for diagnosing pain generators in chronic sciatica was demonstrated, revealing various possible etiologies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Cipriano, P. W., Yoon, D., Gandhi, H., Holley, D., Thakur, D., Hargreaves, B. A., Kennedy, D. J., Smuck, M. W., Cheng, I., Biswal, S. Tags: Clinical Source Type: research

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models
Conclusion: The present findings support the distinct utilities of 11C-PBB3 PET and MRI in rTg4510 and PS19 mice for quantitatively pursuing mechanisms connecting PET-detectable and PET-undetectable tau aggregations to neuronal death, which recapitulate 2 different modes of tau-provoked neurotoxicity. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Ni, R., Ji, B., Ono, M., Sahara, N., Zhang, M.-R., Aoki, I., Nordberg, A., Suhara, T., Higuchi, M. Tags: Basic Source Type: research

Glutamatergic Biomarkers for Cocaine Addiction: A Longitudinal Study Using MR Spectroscopy and mGluR5 PET in Self-Administering Rats
Conclusion: Baseline values of prefrontal glutamate and glycine are associated with future cocaine use. Furthermore, baseline rIGT scores are associated with both sucrose and cocaine. Finally, both glutamate concentration and mGluR5 availability decrease during exposure to cocaine. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: de Laat, B., Weerasekera, A., Leurquin-Sterk, G., Bormans, G., Himmelreich, U., Casteels, C., Van Laere, K. Tags: Basic Source Type: research

Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity
Conclusion: PERSI reduced variability while enhancing discrimination between diagnostic cohorts. Such improvements could lead to more accurate disease staging and robust measurements of changes in tau burden over time for the evaluation of putative therapies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Southekal, S., Devous, M. D., Kennedy, I., Navitsky, M., Lu, M., Joshi, A. D., Pontecorvo, M. J., Mintun, M. A. Tags: Clinical Source Type: research

Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18
Alzheimer disease (AD) is characterized by β-amyloid (Aβ) plaques and tau neurofibrillary tangles. There are several PET imaging biomarkers for Aβ including 11C-PiB and 18F-florbetapir. Recently, PET tracers for tau neurofibrillary tangles have become available and have shown utility in detection and monitoring of neurofibrillary pathology over time. Flortaucipir F 18 is one such tracer. Initial clinical studies indicated greater tau binding in AD and mild cognitive impairment patients than in controls in a pattern consistent with tau pathology observed at autopsy. However, little is known about the reproduc...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Devous, M. D., Joshi, A. D., Navitsky, M., Southekal, S., Pontecorvo, M. J., Shen, H., Lu, M., Shankle, W. R., Seibyl, J. P., Marek, K., Mintun, M. A. Tags: Clinical Source Type: research

Penetrating the Barriers to Successful {alpha}-Radioimmunotherapy
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Carlin, S. Tags: Clinical Source Type: research

The Effect of Total Tumor Volume on the Biologically Effective Dose to Tumor and Kidneys for 177Lu-Labeled PSMA Peptides
Conclusion: This simulation study suggests that in patients with large PSMA-positive tumor volumes, higher activities and peptide amounts can be safely administered to maximize tumor BEDs without exceeding the tolerable BED to the organs at risk. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Begum, N. J., Thieme, A., Eberhardt, N., Tauber, R., DAlessandria, C., Beer, A. J., Glatting, G., Eiber, M., Kletting, P. Tags: Clinical Source Type: research

PET Using a GRPR Antagonist 68Ga-RM26 in Healthy Volunteers and Prostate Cancer Patients
This study was designed to analyze the safety, biodistribution, and radiation dosimetry of a gastrin-releasing peptide receptor (GRPR) antagonist PET tracer, 68Ga-RM26; to assess its clinical diagnostic value in prostate cancer patients; and to perform a direct comparison between GRPR antagonist 68Ga-RM26 and agonist 68Ga-BBN. Methods: Five healthy volunteers were enrolled to validate the safety of 68Ga-RM26 and calculate dosimetry. A total of 28 patients with prostate cancer (17 newly diagnosed and 11 posttherapy) were recruited and provided written informed consent. All the cancer patients underwent PET/CT at 15–30...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Zhang, J., Niu, G., Fan, X., Lang, L., Hou, G., Chen, L., Wu, H., Zhu, Z., Li, F., Chen, X. Tags: Clinical Source Type: research

Sensitivity Comparison of 68Ga-OPS202 and 68Ga-DOTATOC PET/CT in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Phase II Imaging Study
Radiolabeled somatostatin (sst) receptor agonists are integral to the diagnosis of gastroenteropancreatic neuroendocrine tumors (NETs), but detection rates, especially of liver metastases, remain limited even with PET/CT. 68Ga-OPS202 (68Ga-NODAGA-JR11; NODAGA = 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid and JR11 = Cpa-c(dCys-Aph(Hor)-dAph(Cbm)-Lys-Thr-Cys)-dTyr-NH2)), a novel radiolabeled sst receptor antagonist with a high affinity for the sst2 receptor, has the potential to perform better than sst receptor agonists. Here, we present the results of the phase II component of a phase I/II study that evaluated t...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Nicolas, G. P., Schreiter, N., Kaul, F., Uiters, J., Bouterfa, H., Kaufmann, J., Erlanger, T. E., Cathomas, R., Christ, E., Fani, M., Wild, D. Tags: Clinical Source Type: research

Safety, Biodistribution, and Radiation Dosimetry of 68Ga-OPS202 in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Prospective Phase I Imaging Study
Conclusion: 68Ga-OPS202 showed favorable biodistribution and imaging properties, with optimal tumor contrast between 1 and 2 h after injection. Dosimetry analysis revealed that the dose delivered by 68Ga-OPS202 to organs is similar to that delivered by other 68Ga-labeled sst analogs. Further evaluation of 68Ga-OPS202 for PET/CT imaging of NETs is therefore warranted. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Nicolas, G. P., Beykan, S., Bouterfa, H., Kaufmann, J., Bauman, A., Lassmann, M., Reubi, J. C., Rivier, J. E. F., Maecke, H. R., Fani, M., Wild, D. Tags: Clinical Source Type: research

Somatostatin Receptor Imaging of Neuroendocrine Tumors: From Agonists to Antagonists
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Bodei, L., Weber, W. A. Tags: Clinical Source Type: research

First-in-Human Human Epidermal Growth Factor Receptor 2-Targeted Imaging Using 89Zr-Pertuzumab PET/CT: Dosimetry and Clinical Application in Patients with Breast Cancer
Conclusion: This first-in-human study demonstrated safety, dosimetry, biodistribution, and successful HER2-targeted imaging with 89Zr-pertuzumab PET/CT. Potential clinical applications include assessment of the HER2 status of lesions that may not be accessible to biopsy and assessment of HER2 heterogeneity. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Ulaner, G. A., Lyashchenko, S. K., Riedl, C., Ruan, S., Zanzonico, P. B., Lake, D., Jhaveri, K., Zeglis, B., Lewis, J. S., ODonoghue, J. A. Tags: Clinical Source Type: research

Glioma Survival Prediction with Combined Analysis of In Vivo 11C-MET PET Features, Ex Vivo Features, and Patient Features by Supervised Machine Learning
Conclusion: Prediction of survival in amino acid PET–positive glioma patients was highly accurate using computer-supported predictive models based on in vivo, ex vivo, and patient features. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Papp, L., Potsch, N., Grahovac, M., Schmidbauer, V., Woehrer, A., Preusser, M., Mitterhauser, M., Kiesel, B., Wadsak, W., Beyer, T., Hacker, M., Traub-Weidinger, T. Tags: Clinical Source Type: research

Same-Day Imaging Using Small Proteins: Clinical Experience and Translational Prospects in Oncology
Imaging of expression of therapeutic targets may enable stratification of patients for targeted treatments. The use of small radiolabeled probes based on the heavy-chain variable region of heavy-chain–only immunoglobulins or nonimmunoglobulin scaffolds permits rapid localization of radiotracers in tumors and rapid clearance from normal tissues. This makes high-contrast imaging possible on the day of injection. This mini review focuses on small proteins for radionuclide-based imaging that would allow same-day imaging, with the emphasis on clinical applications and promising preclinical developments within the field of...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Krasniqi, A., DHuyvetter, M., Devoogdt, N., Frejd, F. Y., Sorensen, J., Orlova, A., Keyaerts, M., Tolmachev, V. Tags: Focus on Molecular Imaging Source Type: research

{alpha}-Emitters for Radiotherapy: From Basic Radiochemistry to Clinical Studies--Part 1
With a short particle range and high linear energy transfer, α-emitting radionuclides demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides that decay by α-particle emission, only a few of these can reasonably be exploited for therapeutic purposes. Factors including radioisotope availability and physical characteristics (e.g., half-life) can limit their widespread dissemination. The first part of this review will explore the diversity, basic radiochemistry, restrictions, and hurdles of α-emitters. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Poty, S., Francesconi, L. C., McDevitt, M. R., Morris, M. J., Lewis, J. S. Tags: Continuing Education Source Type: research

Imaging of Nonprostate Cancers Using PSMA-Targeted Radiotracers: Rationale, Current State of the Field, and a Call to Arms
Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein that is highly overexpressed on prostate cancer epithelial cells and for which there is a growing body of literature examining the role of small-molecule and antibody radiotracers targeted against this protein for prostate cancer detection and therapy. Despite its name, PSMA is also expressed, to varying degrees, in the neovasculature of a wide variety of nonprostate cancers; indeed, the pathology literature is replete with promising immunohistochemistry findings. Several groups have begun to correlate those pathology-level results with in vi...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Salas Fragomeni, R. A., Amir, T., Sheikhbahaei, S., Harvey, S. C., Javadi, M. S., Solnes, L. B., Kiess, A. P., Allaf, M. E., Pomper, M. G., Gorin, M. A., Rowe, S. P. Tags: The State of the Art Source Type: research

How Should the FDA Review Diagnostic Radiopharmaceuticals?
The purpose of this article is to reconsider the manner in which the U.S. Food and Drug Administration (FDA) reviews diagnostic radiopharmaceuticals. Mass characteristics of several common nonradioactive drugs and several diagnostic radiopharmaceuticals are considered. A history of the regulation of radiopharmaceuticals is presented. The Society of Nuclear Medicine and Molecular Imaging and the American College of Nuclear Medicine should choose the membership of a radiopharmaceutical advisory committee, and the FDA should contract with them to do so. Members of the radiopharmaceutical advisory committee should decide on th...
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Marcus, C. S. Tags: Issues and Controversies Source Type: research

Perspective on How the FDA Should Review Diagnostic Radiopharmaceuticals
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Schwarz, S. W., Clarke, B. Tags: Issues and Controversies Source Type: research

Now Is the Time to Use 18F-FDG PET/CT to Optimize Neoadjuvant Treatment in Triple-Negative Breast Cancer!
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Groheux, D. Tags: Hot Topics Source Type: research

From the Literature
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Newsbriefs
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Aria Razmaria, MD, Awarded 2018 Henkin Fellowship
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: Implementing the Value Initiative
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Greenspan, B. S. Tags: SNMMI Newsline Source Type: research

ABNM Support for Research During Training
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Segall, G. M. Tags: SNMMI Newsline Source Type: research

Outstanding JNM Articles for 2017
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Proceedings of the NCI SBIR Workshop on Molecularly Targeted Radionuclide Therapy
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Authors: Canaria, C. A., Lisa Yeom, M., Capala, J., Narayanan, D. Tags: SNMMI Newsline Source Type: research

Outstanding JNMT Articles for 2017
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

NIH Completes Genomic Analysis of 33 Cancer Types
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 1, 2018 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research

Student
Conclusion Both methods tested proved to be acceptable for administration of Lutathera. However, we observed that Method II does have some advantages over Method I. Method I requires a large bore IV spike to be inserted in the vial septum. There is greater potential to displace the septum on the Lutathera vial using an IV spike compared to a spinal needle. Also, inverting the spiked Lutathera vial in method I has an increased risk of leaks. Back-flushing the Lutathera vial using Method I requires staff to spend more time next to the patient compared to Method II, which increases radiation exposure to the staff. Relatively,...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Dire, A., Gansen, D., Paulsen, A. Tags: TS27: Student Tech Papers III Source Type: research

Evaluation of Tc-99m Sestamibi residual in Becton Dickinson syringes and optimizing the configuration for dispensing.
Conclusions: As a result of this study, Northwestern Medicine has changed its standard practice. Rest Tc-99m sestamibi doses are now drawn up in 3cc syringes QS’d to 1.0mL. Stress Tc-99m sestamibi doses will continue to be drawn up in 3cc syringes QS’d to 1.5mL since this configuration resulted in the least amount of residual activity. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Schaaf, C., Houston, T., McKay, B., Riehle, L., Dillehay, G. Tags: TS27: Student Tech Papers III Source Type: research

Breakdown Significance of MAA in a Syringe and Vial Post Compounding
Conclusions: Looking at the results, there is no significant difference in QC data that would lead to the assumption that the breakdown of MAA is greater in a syringe compared to a vial. Ordering unit doses could save the hospital money and therefore this institution will continue to order unit doses from commercial pharmacies without the concern of HR TcO4- or free TcO4- being a problem. FIGURES/IMAGES:TRIAL 1time (hour)% bound vial% bound syringe00.9940.99410.9920.99320.9890.99230.9880.99140.9910.98750.9920.99760.9890.996TRIAL 2time (hour)% bound vial% bound syringe00.9900.99010.9980.99820.980.99730.9970.98940.9930.99750...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Nagel, M. Tags: TS27: Student Tech Papers III Source Type: research

Comparison of delivered and residual Technetium labeled Diethylenetriamine-pentaacetic acid when ventilating: corrugated vs. non-corrugated tubing.
Conclusions: This study proved that after ventilation, the non-corrugated tubing retained 149.7% less counts when compared to the corrugated tubing. In addition, the ambu bag attached to the non-corrugated tubing retained 119.2% more counts than the ambu bag attached to the corrugated tubing. A higher amount of Tc-DTPA delivered to the lungs would allow for a lower prescribed dose, while keeping the same image sensitivity. Further research should be conducted to see how much the prescribed dose of Tc-DTPA may be reduced to keep patient radiation exposure as low as reasonably achievable. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: McIntosh, C., Voslar, A., Wolter, C. Tags: TS27: Student Tech Papers III Source Type: research

Development of Tc99m DMSA Complex 2 Quality Control Test
Conclusion Using the 51A ITLC paper with 0.9% NaCl is an effective quality control method to identify and differentiate between Tc99m DMSA complex 1 and complex 2. The preferred Tc99m DMSA complex 2 remains mostly at origin with slow migration up the strip, whereas the Tc99m DMSA complex 1 migrates readily up the strip. Performing this quick and simple test on a preparation of Tc99m DMSA can help to ensure the correct complex is present for effective localization and imaging. This test may be more necessary when using compounded formulations of DMSA kits, as opposed to manufactured kits. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Olson, E., Paulsen, A. Tags: TS27: Student Tech Papers III Source Type: research

The Effect of Temperature on Particle Clumping in 99mTechnetium-MAA
Conclusions: Reconstituted 99mTechnetium-MAA kits demonstrate no change in particle clumping when exposed to hot and cold temperatures typically encountered during storage and/or transit. Based on this research, evidence does not support the Draximage™ package insert recommendation for a specific storage temperature following kit reconstitution for the prevention of particle clumps. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Knafel, A., Nielsen, C., Weatherman, K. Tags: TS27: Student Tech Papers III Source Type: research

Radiation exposure assessment of tungsten vial shields vs. lead glass vial shields.
Conclusions:The results demonstrate that tungsten shielding significantly reduces radiation exposure when compared to lead shielding. Based on these findings, Northwestern Memorial Hospital has implemented the use of tungsten vial shields for high activity Tc-99m preparations to minimize radiation exposure and adhere to the ALARA principle. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Ugarte, L., McKay, B., Houston, T., Riehle, L., Dillehay, G. Tags: TS27: Student Tech Papers III Source Type: research

Radiation Exposure Concerns: F18 Fluciclovine radiation exposure from the patient to the public
Conclusion: F18 Fluciclovine patients are being released after their PET scans into unrestricted areas despite emitting radiation that is exceeding NRC level guidelines. Based on this initial study, there needs to be an average decrease of 35% in the amount of radiation the patients are emitting before they are released into an unrestricted area. Since Fluciclovine is imaged immediately after injection, as opposed to having an extended uptake time, a waiting period along with voiding after the scan should be recommended. The radiation exposure from patients undergoing Fluciclovine is higher than that from patients undergoi...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Erwin, A., McMunn, A., Botkin, C., Frye, S., Osman, M. Tags: TS27: Student Tech Papers III Source Type: research

Radiation Exposure to Visitors to Nuclear Medicine Department Waiting Areas
Conclusions: Visitors to nuclear medicine department waiting areas do not receive radiation exposure greater than the limit for the general public of 20 µSv for non-patient sources. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Smith, K. Tags: TS27: Student Tech Papers III Source Type: research

In-house automated synthesis of L-[11C]Glutamine with the use of a siemens H11CN Box.
Conclusions: A method for the automated production of L-[11C]glutamine was achieved with the use of an in-house module attached to a Siemens H11CN module. Specificity and reactivity of the produced L-[11C]glutamine was validated in vitro using a glioblastoma cell line. This provides a platform for consistent-routine production of L-[11C]glutamine which can be used as a potential PET imaging agent. References: [1] L. Zhu, et. al. J. Nucl. Med. 2017, 58, 533-537. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Joseph, S., Sattiraju, A., Oya, S., Jurewicz, A., Castrillon, J., Soffing, M., Mintz, A., Carberry, P. Tags: Tech Papers V: Professional Practices & amp; Educational Exhibits and Radiopharmaceutical Science, Biology amp; Dosimetry Technologist Abstracts Source Type: research

Feasible method to remove the residual impurity after [11C]methionine production
Conclusions: We can be successively removed the impurity (iodide) generated in the [11C]methionine production process using SPE cartridges as introduction an additional anion-exchange resin cartridge. The developed method expected that it can be well adapted to other [11C]radiopharmaceuticals produced by SPE method. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: PARK, H., Moon, B. S., An, H. H., Lee, H. J., Lee, B. C., Lee, W.-W., Kim, S. E. Tags: Tech Papers V: Professional Practices & amp; Educational Exhibits and Radiopharmaceutical Science, Biology amp; Dosimetry Technologist Abstracts Source Type: research

Reduction of Y90 radiation exposure using modified leaded glasses.
The objective of this study is to evaluate how effective eyewear using a combination of lead and acrylic is compared to the standard lead eyeglasses when using Y90. Materials A vial of 56mCi of Y90 was placed at a set distance of 16 cm from a Geiger counter. A standard pair of lead glassed eyewear was placed directly in front of the vial. A piece of (add thickness) acrylic was added to the lead glasses. Six measurements were taken and recorded with lead glasses only and lead glasses + acrylic. Results Data show a clear reduction in exposure rates with average exposure rates reduced from 1.2 mR/hr with lead only glasses to ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Acuff, S., Osborne, D. Tags: Tech Papers V: Professional Practices & amp; Educational Exhibits and Radiopharmaceutical Science, Biology amp; Dosimetry Technologist Abstracts Source Type: research

Improving patient care and efficiencies through multi-departmental collaborations.
Discussion Prior to implementing this procedure, patients were having to stay in the ED and EDOU until at least Monday so the cardiac testing could be performed. Not only was this an inconvenience for the patients, it also reduced the availability of beds for other individuals needing treatment in the ED/EDOU, especially since a vast majority of the testing were negative. Clinical Relevance/Application This process shows the value and importance of multi-departmental collaboration in streamlining patient care. Putting patient care first has provided patients with a better overall experience by decreasing their wait times a...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Mantel, E. Tags: Tech Papers V: Professional Practices & amp; Educational Exhibits and Radiopharmaceutical Science, Biology amp; Dosimetry Technologist Abstracts Source Type: research

Intersocietal Accreditation Commission (IAC) QI Self-Assessment Tool Utilization and Improved Accreditation Outcome
2152Introduction: Accreditation is often viewed as a benchmark of quality. The Intersocietal Accreditation Commission (IAC) has been evaluating and accrediting nuclear medicine and PET labs since 1997. As part of the accreditation process, the quality of staff credentials, equipment, protocols, study appropriateness, imaging, interpretation, reporting, and the quality improvement (QI) program are evaluated. Historically, deficiencies have been identified for approximately 70% of labs applying for IAC nuclear/PET accreditation. In 2016, to assist labs in self-evaluating and improving the quality of their diagnostic imaging ...
Source: Journal of Nuclear Medicine - May 23, 2018 Category: Nuclear Medicine Authors: Costello, M., Farrell, M. Tags: Tech Papers V: Professional Practices & amp; Educational Exhibits and Radiopharmaceutical Science, Biology amp; Dosimetry Technologist Abstracts Source Type: research