Reply: Radioguided Surgery
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Weber, W., Czernin, J. Tags: Letters Source Type: research

Radioguided Surgery
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Mariani, G., Valdes Olmos, R. A., Vidal-Sicart, S., Strauss, H. W. Tags: Letters Source Type: research

PET/MRI Versus PET/CT for Whole-Body Staging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Gerard, S. K. Tags: Letters Source Type: research

{gamma}-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs
Conclusion: GT3-Nano is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice. GT3-Nano can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent 153Sm-EDTMP. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Lee, S.-g., Kalidindi, T. M., Lou, H., Gangangari, K., Punzalan, B., Bitton, A., Lee, C. J., Vargas, H. A., Park, S., Bodei, L., Kharas, M. G., Singh, V. K., Kishore Pillarsetty, N. V., Larson, S. M. Tags: Basic Source Type: research

First-in-Humans Study of 68Ga-DOTA-Siglec-9, a PET Ligand Targeting Vascular Adhesion Protein 1
Conclusion: Intravenous injection of 68Ga-DOTA-Siglec-9 was safe and biodistribution was favorable for testing of the tracer in larger group of patients with rheumatoid arthritis, as is planned for the next phase of clinical trials. The effective radiation dose of 68Ga-DOTA-Siglec-9 was within the same range as the effective radiation doses of other 68Ga-labeled tracers. Injection of 150 MBq of 68Ga-DOTA-Siglec-9 would expose a subject to 3.3 mSv. These findings support the possible repeated clinical use of 68Ga-DOTA-Siglec-9, such as in trials to elucidate the treatment efficacy of novel drug candidates. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Viitanen, R., Moisio, O., Lankinen, P., Li, X.-G., Koivumaki, M., Suilamo, S., Tolvanen, T., Taimen, K., Mali, M., Kohonen, I., Koskivirta, I., Oikonen, V., Virtanen, H., Santalahti, K., Autio, A., Saraste, A., Pirila, L., Nuutila, P., Knuuti, J., Jalkane Tags: Translational Source Type: research

Developing and Implementing an Imaging Optimization Study in Pediatric Nuclear Medicine: Experience and Recommendations from an IAEA-Coordinated Research Project
Conclusion: A dose optimization approach was applied successfully for several procedures commonly performed in pediatric nuclear medicine. Results are reported for renal cortical imaging using 99mTc-DMSA, leading to significant reductions in administered activity (and thus radiation dose). This optimization schema can be successfully implemented by nuclear medicine clinics seeking to improve their approach to imaging children. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Poli, G. L., Coca, M., Torres, L., Fahey, F., Lassmann, M., Chapple, C.-L., Homolka, P., Delis, H. Tags: Clinical Source Type: research

Dose Optimization in Pediatric Studies: Why It Is Important and How It Can Benefit Every Nuclear Medicine Department
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Prior, J. O., Mirzaei, S., Gnesin, S., Lalonde, M. N. Tags: Clinical Source Type: research

First-in-Human Evaluation of 18F-SynVesT-1, a Radioligand for PET Imaging of Synaptic Vesicle Glycoprotein 2A
Conclusion: The novel synaptic vesicle glycoprotein 2A tracer, 18F-SynVesT-1, displays excellent kinetic and in vivo binding properties in humans and holds great potential for the imaging and quantification of synaptic density in neuropsychiatric disorders. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Naganawa, M., Li, S., Nabulsi, N., Henry, S., Zheng, M.-Q., Pracitto, R., Cai, Z., Gao, H., Kapinos, M., Labaree, D., Matuskey, D., Huang, Y., Carson, R. E. Tags: Translational Source Type: research

First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
Conclusion: The 1TC and SRTM2 models are appropriate for quantitative analysis of 11C-LSN3172176 imaging data. 11C-LSN3172176 displayed excellent test–retest reproducibility and is a highly promising ligand to quantify M1 receptors in the human brain. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Naganawa, M., Nabulsi, N., Henry, S., Matuskey, D., Lin, S.-F., Slieker, L., Schwarz, A. J., Kant, N., Jesudason, C., Ruley, K., Navarro, A., Gao, H., Ropchan, J., Labaree, D., Carson, R. E., Huang, Y. Tags: Translational Source Type: research

Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of 11C-DTBZ PET Combined with Correlational Tractography
Conclusion: These findings suggest that impaired integrity of dopaminergic nigrostriatal nerve terminals is associated with nigrostriatal axonal dysfunction in mild to moderate PD. Assessment of nigrostriatal tract integrity may be suitable as a biomarker of early- or even prodromal-stage PD. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Sanchez-Catasus, C. A., Bohnen, N. I., Yeh, F.-C., DCruz, N., Kanel, P., Muller, M. L. T. M. Tags: Clinical Source Type: research

Quantification of Macrophage-Driven Inflammation During Myocardial Infarction with 18F-LW223, a Novel TSPO Radiotracer with Binding Independent of the rs6971 Human Polymorphism
Conclusion: 18F-LW223 is not susceptible to the rs6971 genetic polymorphism in in vitro assays, has favorable in vivo characteristics, and is able to accurately map macrophage-driven inflammation after MI. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: MacAskill, M. G., Stadulyte, A., Williams, L., Morgan, T. E. F., Sloan, N. L., Alcaide-Corral, C. J., Walton, T., Wimberley, C., McKenzie, C.-A., Spath, N., Mungall, W., BouHaidar, R., Dweck, M. R., Gray, G. A., Newby, D. E., Lucatelli, C., Sutherland, A. Tags: Basic Source Type: research

Deep-Learning Generation of Synthetic Intermediate Projections Improves 177Lu SPECT Images Reconstructed with Sparsely Acquired Projections
The aims of this study were to decrease the 177Lu-SPECT acquisition time by reducing the number of projections and to circumvent image degradation by adding deep-learning–generated synthesized projections. Methods: We constructed a deep convolutional U-net–shaped neural network for generation of synthetic intermediate projections (CUSIPs). The number of SPECT investigations was 352 for training, 37 for validation, and 15 for testing. The input was every fourth projection of 120 acquired SPECT projections, that is, 30 projections. The output was 30 synthetic intermediate projections (SIPs) per CUSIP. SPECT image...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Ryden, T., Van Essen, M., Marin, I., Svensson, J., Bernhardt, P. Tags: Clinical Source Type: research

177Lu-Labeled Albumin-Binder-Conjugated PSMA-Targeting Agents with Extremely High Tumor Uptake and Enhanced Tumor-to-Kidney Absorbed Dose Ratio
The use of an albumin binder has been shown to improve tumor uptake of prostate-specific membrane antigen (PSMA)–targeting radiotherapeutic agents. The aim of this study was to develop improved radiotherapeutic agents that combine an optimized affinity-modifying group and optimized albumin binders to maximize the tumor-to-kidney absorbed dose ratio. Methods: 68Ga-labeled DOTA-conjugated lysine-ureido-glutamate–based PSMA-targeting agents bearing various affinity-modifying groups or albumin binders were synthesized and evaluated by PET/CT imaging and biodistribution studies in LNCaP tumor–bearing mice. The...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Kuo, H.-T., Lin, K.-S., Zhang, Z., Uribe, C. F., Merkens, H., Zhang, C., Benard, F. Tags: Basic Source Type: research

High Interobserver Agreement for the Standardized Reporting System SSTR-RADS 1.0 on Somatostatin Receptor PET/CT
Conclusion: SSTR-RADS–guided assessment demonstrated a high concordance rate, even among readers with different levels of experience, supporting the adoption of SSTR-RADS for trials, clinical routine, or outcome studies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Werner, R. A., Derlin, T., Rowe, S. P., Bundschuh, L., Sheikh, G. T., Pomper, M. G., Schulz, S., Higuchi, T., Buck, A. K., Bengel, F. M., Bundschuh, R. A., Lapa, C. Tags: Clinical Source Type: research

Somatostatin Receptor-Targeted Radiopeptide Therapy in Treatment-Refractory Meningioma: Individual Patient Data Meta-analysis
Conclusion: To our knowledge, this individual patient data meta-analysis represents the most comprehensive analysis of the benefits of and adverse events associated with SSTR-targeted PRRT for treatment-refractory meningioma. The treatment was well tolerated, achieved disease control in most cases, and showed promising results regarding PFS and OS. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Mirian, C., Duun-Henriksen, A. K., Maier, A., Pedersen, M. M., Jensen, L. R., Bashir, A., Graillon, T., Hrachova, M., Bota, D., van Essen, M., Spanjol, P., Kreis, C., Law, I., Broholm, H., Poulsgaard, L., Fugleholm, K., Ziebell, M., Munch, T., Walter, M. Tags: Clinical Source Type: research

Longitudinal Molecular Imaging of Progesterone Receptor Reveals Early Differential Response to Endocrine Therapy in Breast Cancer with an Activating ESR1 Mutation
Conclusion: Molecular imaging of PR expression dynamics could be a noninvasive approach for early identification of reduced effectiveness of endocrine therapy resulting from activating ESR1 mutations. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Kumar, M., Salem, K., Jeffery, J. J., Yan, Y., Mahajan, A. M., Fowler, A. M. Tags: Basic Source Type: research

Phase I Study of 99mTc-ADAPT6, a Scaffold Protein-Based Probe for Visualization of HER2 Expression in Breast Cancer
Radionuclide molecular imaging of human epidermal growth factor receptor type 2 (HER2) expression may help to stratify breast and gastroesophageal cancer patients for HER2-targeting therapies. Albumin-binding domain–derived affinity proteins (ADAPTs) are a new type of small (46–59 amino acids) protein useful as probes for molecular imaging. The aim of this first-in-humans study was to evaluate the biodistribution, dosimetry, and safety of the HER2-specific 99mTc-ADAPT6. Methods: Twenty-nine patients with primary breast cancer were included. In 22 patients with HER2-positive (n = 11) or HER2-negative (n = 11) hi...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Bragina, O., von Witting, E., Garousi, J., Zelchan, R., Sandstrom, M., Orlova, A., Medvedeva, A., Doroshenko, A., Vorobyeva, A., Lindbo, S., Borin, J., Tarabanovskaya, N., Sorensen, J., Hober, S., Chernov, V., Tolmachev, V. Tags: Clinical Source Type: research

Surveillance of Clinically Complete Responders Using Serial 18F-FDG PET/CT Scans in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy
Active surveillance for patients with esophageal cancer and a clinically complete response (cCR) after neoadjuvant chemoradiotherapy (nCRT) is being studied. Active surveillance requires accurate clinical response evaluations. 18F-FDG PET/CT might be able to detect local tumor recurrence after nCRT as soon as the esophagus recovers from radiation-induced esophagitis. The aims of this study were to assess the value of serial 18F-FDG PET/CT scans for detecting local recurrence in patients beyond 3 mo after nCRT and to determine when radiation-induced esophagitis has resolved. Methods: This retrospective multicenter study inc...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Valkema, M. J., van der Wilk, B. J., Eyck, B. M., Wijnhoven, B. P. L., Spaander, M. C. W., Doukas, M., Lagarde, S. M., Schreurs, W. M. J., Roef, M. J., van Lanschot, J. J. B., Valkema, R. Tags: Clinical Source Type: research

First Experience Using 18F-Flubrobenguane PET Imaging in Patients with Suspected Pheochromocytoma or Paraganglioma
Conclusion: Our preliminary data suggest 18F-flubrobenguane PET to be a new, effective staging tool for patients with suspected pheochromocytoma or paraganglioma. Major advantages are the fast acquisition and high spatial resolution of PET imaging and the intense uptake in tumor lesions, facilitating detection. Further studies are warranted to define the role of 18F-flubrobenguane PET, particularly in comparison to standard diagnostic procedures such as MRI or 123I-MIBG SPECT/CT. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Kessler, L., Schlitter, A. M., Kronke, M., von Werder, A., Tauber, R., Maurer, T., Robinson, S., Orlandi, C., Herz, M., Yousefi, B. H., Nekolla, S. G., Schwaiger, M., Eiber, M., Rischpler, C. Tags: Translational Source Type: research

Lymphocyte Infiltration Determines the Hypoxia-Dependent Response to Definitive Chemoradiation in Head-and-Neck Cancer: Results from a Prospective Imaging Trial
Conclusion: This analysis established a clinical hypoxia-immune score that predicted treatment responses and outcomes in HNSCC patients undergoing chemoradiation and may help to devise novel concepts for biology-driven personalization of chemoradiation. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Nicolay, N. H., Ruhle, A., Wiedenmann, N., Niedermann, G., Mix, M., Weber, W. A., Baltas, D., Werner, M., Kayser, G., Grosu, A.-L. Tags: Clinical Source Type: research

Treatment Monitoring of Immunotherapy and Targeted Therapy Using 18F-FET PET in Patients with Melanoma and Lung Cancer Brain Metastases: Initial Experiences
Conclusion: 18F-FET PET may add valuable information for treatment monitoring in BM patients treated with ICI or TT. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Galldiks, N., Abdulla, D. S. Y., Scheffler, M., Wolpert, F., Werner, J.-M., Hullner, M., Stoffels, G., Schweinsberg, V., Schlaak, M., Kreuzberg, N., Landsberg, J., Lohmann, P., Ceccon, G., Baues, C., Trommer, M., Celik, E., Ruge, M. I., Kocher, M., Marnit Tags: Clinical Source Type: research

The Evolution of PET/MR Is Hindered by Our Fields Reluctance to Provide Critical Evaluation
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Kesner, A. L. Tags: Editorials Source Type: research

Advances in Imaging Reactive Oxygen Species
Reactive oxygen species (ROS) play a pivotal role in many cellular processes and can be either beneficial or harmful. The design of ROS-sensitive fluorophores has allowed for imaging of specific activity and has helped elucidate mechanisms of action for ROS. Understanding the oxidative role of ROS in the many roles it plays allows us to understand the human body. This review provides a concise overview of modern advances in the field of ROS imaging. Indeed, much has been learned about the role of ROS throughout the years; however, it has recently been shown that using nanoparticles, rather than individual small organic flu...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Espinoza, E. M., Roise, J. J., Li, I.-C., Das, R., Murthy, N. Tags: Focus on Molecular Imaging Source Type: research

Agent Optimization: Absorption, Distribution, Metabolism, Excretion, Dose, and Decay
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Brechbiel, M. W. Tags: Hot Topics Source Type: research

Bone Mineral Density: Clinical Relevance and Quantitative Assessment
Bone mineral density (BMD) measurement by dual-energy x-ray absorptiometry (DXA) is an internationally accepted standard-of-care screening tool used to assess fragility-fracture risk. Society guidelines have recommended which populations may benefit from DXA screening and the use of the fracture risk assessment tool (FRAX) to guide decisions regarding pharmacologic treatment for osteoporosis. According to the U.S. National Osteoporosis Foundation guidelines, postmenopausal women and men at least 50 y old with osteopenic BMD warrant pharmacologic treatment if they have a FRAX-calculated 10-y probability of at least 3% for h...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Haseltine, K. N., Chukir, T., Smith, P. J., Jacob, J. T., Bilezikian, J. P., Farooki, A. Tags: Continuing Education Source Type: research

The Role of 89Zr-Immuno-PET in Navigating and Derisking the Development of Biopharmaceuticals
The identification of molecular drivers of disease and the compelling rise of biotherapeutics have impacted clinical care but have also come with challenges. Such therapeutics include peptides, monoclonal antibodies, antibody fragments and nontraditional binding scaffolds, activatable antibodies, bispecific antibodies, immunocytokines, antibody–drug conjugates, enzymes, polynucleotides, and therapeutic cells, as well as alternative drug carriers such as nanoparticles. Drug development is expensive, attrition rates are high, and efficacy rates are lower than desired. Almost all these drugs, which in general have a lon...
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: van Dongen, G. A. M. S., Beaino, W., Windhorst, A. D., Zwezerijnen, G. J. C., Oprea-Lager, D. E., Hendrikse, N. H., van Kuijk, C., Boellaard, R., Huisman, M. C., Vugts, D. J. Tags: The State of the Art Source Type: research

Leadership in Medicine, Industry, and Innovation: A Conversation Between Jorg F. Debatin and Thomas Beyer
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Debatin, J. F., Beyer, T. Tags: Discussions with Leaders Source Type: research

From the Literature
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Newsbriefs
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: SNMMI Virtual Meetings Go Above and Beyond
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Authors: Pappas, V. Tags: SNMMI Newsline Source Type: research

SNMMI 177Lu Dosimetry Challenge 2021
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Launches Online Career Center
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

JNM Announces New Website and Social Media Sites
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Newsline
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 29, 2021 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research

SNMMI 2021 Annual Meeting
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 24, 2021 Category: Nuclear Medicine Authors: Packard, A., Buehner, T. M. Tags: SNMMI Newsline Source Type: research

Reply: Data-Driven Motion Correction in Clinical PET: A Joint Accomplishment of Creative Academia and Industry
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Walker, M. D., Bradley, K. M., McGowan, D. R. Tags: Letters Source Type: research

Reply: Automated Segmentation of TMTV in DLBCL Patients: What About Method Measurement Uncertainty?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Barrington, S. F., Zwezerijnen, B. G. J. C., de Vet, H. C. W., Heymans, M. W., Boellaard, R. Tags: Letters Source Type: research

Newsbriefs
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: Advocating for Our Field
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Packard, A. B. Tags: SNMMI Newsline Source Type: research

In Memoriam: Anna Celler, PhD, 1951-2020
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Rahmim, A., Uribe, C., MacKay, A., Wells, G. Tags: SNMMI Newsline Source Type: research

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(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Walker, M. D., Bradley, K. M., McGowan, D. R. Tags: Departments Source Type: research

Data-Driven Motion Correction in Clinical PET: A Joint Accomplishment of Creative Academia and Industry
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Kesner, A. L. Tags: Departments Source Type: research

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(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Barrington, S. F., Zwezerijnen, B. G. J. C., de Vet, H. C. W., Heymans, M. W., Boellaard, R. Tags: Departments Source Type: research

Automated Segmentation of TMTV in DLBCL Patients: What About Method Measurement Uncertainty?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Laffon, E., Marthan, R. Tags: Departments Source Type: research

Global Issues of Radiopharmaceutical Access and Availability: A Nuclear Medicine Global Initiative Project
Conclusion: Strategies to address access and availability of radiopharmaceuticals are outlined, to enable timely and equitable patient access to nuclear medicine procedures worldwide. In the face of disruptions to global supply chains by the coronavirus disease 2019 outbreak, renewed focus on ensuring a reliable supply of radiopharmaceuticals is a major priority for nuclear medicine practice globally. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Cutler, C. S., Bailey, E., Kumar, V., Schwarz, S. W., Bom, H.-S., Hatazawa, J., Paez, D., Orellana, P., Louw, L., Mut, F., Kato, H., Chiti, A., Frangos, S., Fahey, F., Dillehay, G., Oh, S. J., Lee, D. S., Lee, S.-T., Nunez-Miller, R., Bandhopadhyaya, G., Tags: Radiopharmaceuticals Source Type: research

Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (–1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J–specific binding. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Naganawa, M., Gallezot, J.-D., Finnema, S. J., Matuskey, D., Mecca, A., Nabulsi, N. B., Labaree, D., Ropchan, J., Malison, R. T., DSouza, D. C., Esterlis, I., Detyniecki, K., van Dyck, C. H., Huang, Y., Carson, R. E. Tags: Clinical Source Type: research

Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies
Conclusion: Our findings suggest that in TSPO PET studies, nondisplaceable binding can differ between patient groups and conditions and should therefore be considered. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Laurell, G. L., Plaven-Sigray, P., Jucaite, A., Varrone, A., Cosgrove, K. P., Svarer, C., Knudsen, G. M., Karolinska Schizophrenia Project Consortium, Ogden, R. T., Zanderigo, F., Cervenka, S., Hillmer, A. T., Schain, M. Tags: Clinical Source Type: research

PET Imaging Reveals Early Pulmonary Perfusion Abnormalities in HIV Infection Similar to Smoking
Conclusion: In nonsmokers living with well-controlled HIV and minimal radiographic emphysema, HIV infection contributes to pulmonary perfusion abnormalities similar to smokers. These data indicate the onset of subclinical pulmonary perfusion abnormalities that could herald the development of significant lung disease in these susceptible individuals. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Authors: Kohli, P., Kelly, V. J., Hibbert, K. A., Corleis, B., Kone, M., Cho, J. L., DeFaria-Yeh, D., Kwon, D. S., Medoff, B. D., Harris, R. S., Winkler, T. Tags: Clinical Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 23, 2021 Category: Nuclear Medicine Tags: Erratum Source Type: research