Radiology Secrets Plus, Fourth Edition
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Kim, E. E. Tags: Book Reviews Source Type: research

Respiratory Motion Compensation for PET/CT with Motion Information Derived from Matched Attenuation-Corrected Gated PET Data
In this study, we established a motion correction framework to address these limitations. Methods: In the proposed framework, the combined emission–transmission reconstruction algorithm was used for phase-matched gated PET reconstructions to facilitate the motion model building. An event-by-event nonrigid respiratory motion compensation method with correlations between internal organ motion and external respiratory signals was used to correct both intracycle and intercycle breathing variations. The PET reference gate was automatically determined by a newly proposed CT-matching algorithm. We applied the new framework ...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Lu, Y., Fontaine, K., Mulnix, T., Onofrey, J. A., Ren, S., Panin, V., Jones, J., Casey, M. E., Barnett, R., Kench, P., Fulton, R., Carson, R. E., Liu, C. Tags: Physics And Instrumentation Source Type: research

Concurrent Respiratory Motion Correction of Abdominal PET and Dynamic Contrast-Enhanced-MRI Using a Compressed Sensing Approach
Conclusion: We presented a method that allows the simultaneous acquisition of respiratory motion–corrected diagnostic quality DCE-MRI and quantitatively accurate PET data in an integrated PET/MR scanner with negligible prolongation in acquisition time compared with routine PET/DCE-MRI protocols. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Fuin, N., Catalano, O. A., Scipioni, M., Canjels, L. P. W., Izquierdo-Garcia, D., Pedemonte, S., Catana, C. Tags: Physics and Instrumentation Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Tags: Erratum Source Type: research

Clinical Impact of Respiratory Motion Correction in Simultaneous PET/MR, Using a Joint PET/MR Predictive Motion Model
Conclusion: We demonstrated significant improvements in quantification and detection of PET-avid lesions, with specific case study examples showing where motion correction has the potential to affect diagnosis or patient care. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Manber, R., Thielemans, K., Hutton, B. F., Wan, S., Fraioli, F., Barnes, A., Ourselin, S., Arridge, S., Atkinson, D. Tags: Physics and Instrumentation Source Type: research

Dual-Isotope Cryoimaging Quantitative Autoradiography: Investigating Antibody-Drug Conjugate Distribution and Payload Delivery Through Imaging
Conclusion: The combination of a veteran established autoradiography technology with advanced image analysis methodologies affords an experimental tool that can support detailed characterization of ADC tumor penetration and pharmacokinetics. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Ilovich, O., Qutaish, M., Hesterman, J. Y., Orcutt, K., Hoppin, J., Polyak, I., Seaman, M., Abu-Yousif, A. O., Cvet, D., Bradley, D. P. Tags: Basic Source Type: research

"Standing by" for Bystander Effects: Dual-Isotope Imaging of Antibody-Drug Conjugate and Payload Distribution
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Cilliers, C., Thurber, G. M. Tags: Basic Source Type: research

Patient-Specific Computational Model and Dosimetry Calculations for PET/CT of a Patient Pregnant with Twins
Conclusion: Our approach to constructing personalized computational models allows estimation of a patient-specific radiation dose, even in cases with unusual anatomic features such as a twin pregnancy. Our results also show that, even in twins, the fetal organ doses from both 18F-FDG and CT present a certain variability linked to the anatomic characteristics. The CT fetal dose is smaller than the 18F-FDG PET dose. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Xie, T., Zanotti-Fregonara, P., Edet-Sanson, A., Zaidi, H. Tags: Clinical Source Type: research

Age-Related Change in 5-HT6 Receptor Availability in Healthy Male Volunteers Measured with 11C-GSK215083 PET
Conclusion: To our knowledge, this was the first in vivo study on humans to examine the effect of age on 5-HT6 receptor availability. The study demonstrated a significant age-related decline in 5-HT6 availability (BPND) in the caudate and putamen. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Radhakrishnan, R., Nabulsi, N., Gaiser, E., Gallezot, J.-D., Henry, S., Planeta, B., Lin, S.-f., Ropchan, J., Williams, W., Morris, E., DSouza, D. C., Huang, Y., Carson, R. E., Matuskey, D. Tags: Clinical Source Type: research

The Metabolic Pattern of Idiopathic REM Sleep Behavior Disorder Reflects Early-Stage Parkinson Disease
In this study, we identify the metabolic pattern underlying iRBD and compare it with the known PD pattern. To understand the relevance of the iRBD pattern to disease progression, we studied the expression of the iRBD pattern in de novo PD patients. Methods: The iRBD-related pattern was identified in 18F-FDG PET scans of 21 patients with polysomnographically confirmed iRBD and 19 controls using spatial covariance analysis. Expression of the iRBD-related pattern was subsequently computed in 18F-FDG PET scans of 44 controls and 38 de novo, treatment-naïve PD patients. Of these 38 PD patients, 24 had probable REM sleep be...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Meles, S. K., Renken, R. J., Janzen, A., Vadasz, D., Pagani, M., Arnaldi, D., Morbelli, S., Nobili, F., Mayer, G., Leenders, K. L., Oertel, W. H., the REMPET Study Group Tags: Clinical Source Type: research

Regional Myocardial Perfusion Disturbance in Experimental Chronic Chagas Cardiomyopathy
Conclusion: Resting MPDs are frequent in experimental CCC and are associated with myocardial inflammation but do not designate scar tissue, corresponding to regions with metabolically viable myocardium. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Lemos de Oliveira, L. F., Thackeray, J. T., Marin Neto, J. A., Dias Romano, M. M., Vieira de Carvalho, E. E., Mejia, J., Tanaka, D. M., Kelly da Silva, G., Abdalla, D. R., Malamut, C., Bengel, F. M., de Lourdes Higuchi, M., Schmidt, A., Cunha-Neto, E., Si Tags: Basic Source Type: research

A Tumor-Imaging Method Targeting Cancer-Associated Fibroblasts
Conclusion: Radiolabeled FAPIs allow fast imaging with very high contrast in tumors having a high stromal content and may therefore serve as pantumor agents. Coupling of these molecules to DOTA or other chelators allows labeling not only with 68Ga but also with therapeutic isotopes such as 177Lu or 90Y. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Loktev, A., Lindner, T., Mier, W., Debus, J., Altmann, A., Jager, D., Giesel, F., Kratochwil, C., Barthe, P., Roumestand, C., Haberkorn, U. Tags: Translational Source Type: research

Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein
Conclusion: FAPI-04 represents a promising tracer for both diagnostic imaging and, possibly, targeted therapy of malignant tumors with a high content of activated fibroblasts, such as breast cancer. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Lindner, T., Loktev, A., Altmann, A., Giesel, F., Kratochwil, C., Debus, J., Jager, D., Mier, W., Haberkorn, U. Tags: Translational Source Type: research

Fibroblast-Activating Protein: Targeting the Roots of the Tumor Microenvironment
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Siveke, J. T. Tags: Translational Source Type: research

68Ga-PSMA-HBED-CC Uptake in Cervical, Celiac, and Sacral Ganglia as an Important Pitfall in Prostate Cancer PET Imaging
The study aims to investigate the presence of physiologic prostate-specific membrane antigen (68Ga-PSMA)-ligand uptake on PET in cervical, celiac, and sacral ganglia of the sympathetic trunk as a pitfall for lymph node metastases in prostate cancer imaging. Methods: Four hundred seven patients who underwent Glu-NH-CO-NH-Lys radiolabeled with 68Ga-gallium N,N-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N-diacetic acid (68Ga-PSMA-HBED-CC) PET (combined with a diagnostic CT) were retrospectively analyzed. The number of 68Ga-PSMA PET–positive cervical, celiac, and sacral ganglia was determined, and the configu...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Rischpler, C., Beck, T. I., Okamoto, S., Schlitter, A. M., Knorr, K., Schwaiger, M., Gschwend, J., Maurer, T., Meyer, P. T., Eiber, M. Tags: Clinical Source Type: research

Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody
Conclusion: Dual-modality imaging using the anti-PSCA cys-diabody resulted in high-contrast immuno-PET/NIRF images of PDX-PDACs, suggesting that this imaging agent might offer both noninvasive whole-body imaging to localize PSCA-positive pancreatic cancer and fluorescence image–guided identification of tumor margins during surgery. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Zettlitz, K. A., Tsai, W.-T. K., Knowles, S. M., Kobayashi, N., Donahue, T. R., Reiter, R. E., Wu, A. M. Tags: Basic Source Type: research

Detection Threshold and Reproducibility of 68Ga-PSMA11 PET/CT in a Mouse Model of Prostate Cancer
Conclusion: The in vivo relationship between 68Ga-PSMA11 PET/CT and PSMA expression level in a murine model of prostate cancer was robust for lower cell surface PSMA expression levels (≤22,000/cell). Thus, preclinical 68Ga-PSMA11 PET/CT can be used as an imaging biomarker to test PSMA-targeted interventions in murine models. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Luckerath, K., Stuparu, A. D., Wei, L., Kim, W., Radu, C. G., Mona, C. E., Calais, J., Rettig, M., Reiter, R. E., Czernin, J., Slavik, R., Herrmann, K., Eiber, M., Fendler, W. P. Tags: Basic Source Type: research

Radioiodinated Small-Molecule Tyrosine Kinase Inhibitor for HER2-Selective SPECT Imaging
Conclusion: The radiolabeled HER2-selective inhibitor 125/131I-IBA-CP is a promising probe for in vivo detection of HER2-positive tumors. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Tang, L., Peng, C., Tang, B., Li, Z., Wang, X., Li, J., Gao, F., Huang, L., Xu, D., Zhang, P., Zhuang, R., Su, X., Chen, X., Zhang, X. Tags: Basic Source Type: research

18F-Fludarabine PET for Lymphoma Imaging: First-in-Humans Study on DLBCL and CLL Patients
Conclusion: 18F-fludarabine PET might well be a promising tool for lymphoproliferative diseases. The radiation dose of this radiopharmaceutical is below that of 18F-FDG. The specificity of this PET probe for lymphoid cells, its absence of accumulation in reactive tissues, and its feasibility for detection of bone marrow infiltration might play an innovative role in lymphoma imaging. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Chantepie, S., Hovhannisyan, N., Guillouet, S., Pelage, J.-P., Ibazizene, M., Bodet-Milin, C., Carlier, T., Gac, A.-C., Reboursiere, E., Vilque, J.-P., Kraeber-Bodere, F., Manrique, A., Damaj, G., Leporrier, M., Barre, L. Tags: Clinical Source Type: research

Intraindividual Comparison of 99mTc-Methylene Diphosphonate and Prostate-Specific Membrane Antigen Ligand 99mTc-MIP-1427 in Patients with Osseous Metastasized Prostate Cancer
Conclusion: PSMA scanning provided a clear advantage over bone scanning by reducing the number of equivocal findings in most patients. SPECT/CT was pivotal for differentiating bone metastases from extraosseous tumor lesions. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Rathke, H., Afshar-Oromieh, A., Giesel, F. L., Kremer, C., Flechsig, P., Haufe, S., Mier, W., Holland-Letz, T., De Bucourt, M., Armor, T., Babich, J. W., Haberkorn, U., Kratochwil, C. Tags: Clinical Source Type: research

A Prospective Study of Quantitative SPECT/CT for Evaluation of Lung Shunt Fraction Before SIRT of Liver Tumors
The lung shunt fraction (LSF) is estimated using 99mTc-macroaggregated albumin (99mTc-MAA) imaging before selective internal radiotherapy (SIRT) of the liver to reduce the risk of pulmonary irradiation. Generally, planar scans are acquired after injection of 99mTc-MAA into the hepatic artery. However, the validity of this approach is limited by differences in attenuation between liver and lung tissue as well as inaccurate segmentation of the organs. The aim of this study was to evaluate quantitative SPECT/CT for LSF assessment in a prospective clinical cohort. Methods: Fifty consecutive patients intended to undergo SIRT we...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Dittmann, H., Kopp, D., Kupferschlaeger, J., Feil, D., Groezinger, G., Syha, R., Weissinger, M., la Fougere, C. Tags: Clinical Source Type: research

Immediate Postablation 18F-FDG Injection and Corresponding SUV Are Surrogate Biomarkers of Local Tumor Progression After Thermal Ablation of Colorectal Carcinoma Liver Metastases
Conclusion: The SUV ratio and minimum margin size can independently predict colorectal metastasis local tumor progression after liver ablation when there are no viable tumor cells on immediate postablation biopsies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Cornelis, F. H., Petre, E. N., Vakiani, E., Klimstra, D., Durack, J. C., Gonen, M., Osborne, J., Solomon, S. B., Sofocleous, C. T. Tags: Clinical Source Type: research

Insights into Trace Metal Metabolism in Health and Disease from PET: "PET Metallomics"
Essential trace metals such as copper, zinc, iron, and manganese perform critical functions in cellular and physiologic processes including catalytic, regulatory, and signaling roles. Disturbed metal homeostasis is associated with the pathogenesis of diseases such as dementia, cancer, and inherited metabolic abnormalities. Intracellular pathways involving essential metals have been extensively studied but whole-body fluxes and transport between different compartments remain poorly understood. The growing availability of PET scanners and positron-emitting isotopes of key essential metals, particularly 64Cu, 63Zn, and 52Mn, ...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Bartnicka, J. J., Blower, P. J. Tags: Focus on Molecular Imaging Source Type: research

An Overview of PET Radiochemistry, Part 1: The Covalent Labels 18F, 11C, and 13N
This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides 11C, 13N, and 18F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Pichler, V., Berroteran-Infante, N., Philippe, C., Vraka, C., Klebermass, E.-M., Balber, T., Pfaff, S., Nics, L., Mitterhauser, M., Wadsak, W. Tags: Continuing Education Source Type: research

Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies
Dysregulated cellular metabolism is a characteristic feature of malignancy that has been exploited for both imaging and targeted therapy. With regard to imaging, deranged glucose metabolism has been leveraged using 18F-FDG PET. Metabolic imaging with 18F-FDG, however, probes only the early steps of glycolysis; the complexities of metabolism beyond these early steps in this single pathway are not directly captured. New imaging technologies—both PET with novel radiotracers and MR-based methods—provide unique opportunities to investigate other aspects of cellular metabolism and expand the metabolic imaging armamen...
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Pantel, A. R., Ackerman, D., Lee, S.-C., Mankoff, D. A., Gade, T. P. Tags: The State of the Art Source Type: research

Oligometastatic Prostate Cancer: Molecular Imaging and Clinical Management Implications in the Era of Precision Oncology
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Jadvar, H. Tags: Hot Topics Source Type: research

The Quality and Impact of JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Czernin, J. Tags: Editor ' s Page Source Type: research

Newsbriefs
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: Training Future Nuclear Medicine Physicians
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Minoshima, S. Tags: SNMMI Newsline Source Type: research

Longitudinal Assessment (CertLink): Listening to and Enhancing ABNM Diplomate Experiences
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Gordon, L. Tags: SNMMI Newsline Source Type: research

2018 SNMMI Highlights Lecture: Cardiovascular Nuclear and Molecular Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Authors: Sadeghi, M. M. Tags: SNMMI Newsline Source Type: research

This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 4, 2018 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research

PET/MR Imaging: A Case-Based Approach
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Kim, E. E. Tags: Book Reviews Source Type: research

Nuclear Medicine Training: Two Different Pathways?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Biersack, H. J. Tags: Letters Source Type: research

A Noninvasive Method for Quantifying Cerebral Blood Flow by Hybrid PET/MRI
Conclusion: These findings demonstrate the accuracy of this hybrid PET/MRI approach, which might prove useful in patients for whom obtaining accurate CBF measurements is challenging. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Ssali, T., Anazodo, U. C., Thiessen, J. D., Prato, F. S., St. Lawrence, K. Tags: Physics and Instrumentation Source Type: research

A Postreconstruction Harmonization Method for Multicenter Radiomic Studies in PET
Conclusion: The proposed harmonization method is efficient at removing the multicenter effect for textural features and SUVs. The method is easy to use, retains biologic variations not related to a center effect, and does not require any feature recalculation. Such harmonization allows for multicenter studies and for external validation of radiomic models or cutoffs and should facilitate the use of radiomic models in clinical practice. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Orlhac, F., Boughdad, S., Philippe, C., Stalla-Bourdillon, H., Nioche, C., Champion, L., Soussan, M., Frouin, F., Frouin, V., Buvat, I. Tags: Physics and Instrumentation Source Type: research

Direct Imaging of Drug Distribution and Target Engagement of the PARP Inhibitor Rucaparib
Conclusion: The label-free, intrinsic fluorescence of rucaparib can be exploited to interrogate drug distribution and target binding, critical factors toward improving treatment efficacy and outcome. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Kossatz, S., Carney, B., Farley, C., Weber, W. A., Drain, C. M., Reiner, T. Tags: Basic Source Type: research

Noninvasive Imaging of Drug-Induced Liver Injury with 18F-DFA PET
Conclusion: Our findings suggest that PET imaging with 18F-DFA can be used to visualize and quantify drug-induced acute liver injury and may provide information on the progression from liver injury to hepatic failure. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Salas, J. R., Chen, B. Y., Wong, A., Duarte, S., Angarita, S. A. K., Lipshutz, G. S., Witte, O. N., Clark, P. M. Tags: Basic Source Type: research

Small-Animal 18F-FDG PET for Research on Octopus vulgaris: Applications and Future Directions in Invertebrate Neuroscience and Tissue Regeneration
Conclusion: This study represents a stepping-stone to the use of noninvasive functional techniques for addressing questions about invertebrate neuroscience and regenerative medicine. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Zullo, L., Buschiazzo, A., Massollo, M., Riondato, M., Democrito, A., Marini, C., Benfenati, F., Sambuceti, G. Tags: Basic Source Type: research

In Vivo Characterization of 4 68Ga-Labeled Multimeric RGD Peptides to Image {alpha}v{beta}3 Integrin Expression in 2 Human Tumor Xenograft Mouse Models
Conclusion: All tracers showed sufficient targeting of αvβ3 integrin expression to allow for tumor detection. Although the highest tumor uptake was found for 68Ga-FSC-(RGD)3 and 68Ga-THP-(RGD)3 in the SK-RC-52 and FaDu models, respectively, selection of the optimal tracer for specific diagnostic applications also depends on tumor-to-blood ratio and uptake in normal tissues; these factors should therefore also be considered. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Lobeek, D., Franssen, G. M., Ma, M. T., Wester, H.-J., Decristoforo, C., Oyen, W. J. G., Boerman, O. C., Terry, S. Y. A., Rijpkema, M. Tags: Basic Source Type: research

Retrospective Voxel-Based Dosimetry for Assessing the Ability of the Body-Surface-Area Model to Predict Delivered Dose and Radioembolization Outcome
Conclusion: In our population, average tumor-absorbed dose and DVH metrics were associated with tumor response. However, the activity calculated by the BSA method could have been increased to reach the recommended tumor dose threshold. Tumor uptake, target and nontarget volumes, and dose distribution heterogeneity should be considered for activity planning. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Kafrouni, M., Allimant, C., Fourcade, M., Vauclin, S., Delicque, J., Ilonca, A.-D., Guiu, B., Manna, F., Molinari, N., Mariano-Goulart, D., Ben Bouallegue, F. Tags: Clinical Source Type: research

Comparative Dosimetry for 68Ga-DOTATATE: Impact of Using Updated ICRP Phantoms, S Values, and Tissue-Weighting Factors
Conclusion: This study showed that the effective dose coefficient was slightly overestimated for CE phantoms, compared with ICRP 110 phantoms using the latest tissue-weighting factors from ICRP 103. The more detailed handling of electron transport in the latest phantom calculations gives significant differences in estimates of the absorbed dose to stem cells in the walled organs of the alimentary tract. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Josefsson, A., Hobbs, R. F., Ranka, S., Schwarz, B. C., Plyku, D., Willegaignon de Amorim de Carvalho, J., Buchpiguel, C. A., Sapienza, M. T., Bolch, W. E., Sgouros, G. Tags: Clinical Source Type: research

Whole-Body Biodistribution and Dosimetry of the Dopamine Transporter Radioligand 18F-FE-PE2I in Human Subjects
Conclusion: The effective dose is within the same order of magnitude as other commonly used PET imaging agents as well as DAT agents. The reasonable effective dose, together with the previously reported favorable characteristics for DAT imaging and quantification, indicates that 18F-FE-PE2I is a suitable radioligand for DAT imaging. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Lizana, H., Johansson, L., Axelsson, J., Larsson, A., Ogren, M., Linder, J., Halldin, C., Varrone, A., Mo, S. J. Tags: Clinical Source Type: research

18F-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test-Retest Reproducibility and Quantification of Neuroinflammation
Activated microglia express the translocator protein (TSPO) on the outer mitochondrial membrane. 18F-PBR111 is a second-generation PET ligand that specifically binds the TSPO, allowing in vivo visualization and quantification of neuroinflammation. The aim of this study was to evaluate whether the test–retest variability of 18F-PBR111 in healthy controls is acceptable to detect a psychosis-associated neuroinflammatory signal in schizophrenia. Methods: Dynamic 90-min 18F-PBR111 scans were obtained in 17 healthy male controls (HCs) and 11 male schizophrenia patients (SPs) during a psychotic episode. Prior genotyping for...
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Ottoy, J., De Picker, L., Verhaeghe, J., Deleye, S., wyffels, L., Kosten, L., Sabbe, B., Coppens, V., Timmers, M., van Nueten, L., Ceyssens, S., Stroobants, S., Morrens, M., Staelens, S. Tags: Clinical Source Type: research

Head-to-Head Comparison of 11C-PBR28 and 18F-GE180 for Quantification of the Translocator Protein in the Human Brain
Conclusion: The VT of 18F-GE180 was about 20 times smaller than that of 11C-PBR28 because of low penetration into the brain from the vascular compartment. In addition, kinetic modeling of 18F-GE180 was more challenging than that of 11C-PBR28. Therefore, compared with 11C-PBR28, 18F-GE180 had unfavorable characteristics for TSPO imaging of the brain. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Zanotti-Fregonara, P., Pascual, B., Rizzo, G., Yu, M., Pal, N., Beers, D., Carter, R., Appel, S. H., Atassi, N., Masdeu, J. C. Tags: Clinical Source Type: research

Imaging for Pulmonary Embolism in Sickle Cell Disease: A 17-Year Experience
Conclusion: In sickle cell disease patients with suspected pulmonary embolism, positive imaging rates were low for any given clinical presentation, but 11% of the cohort was diagnosed with pulmonary embolism over the 17-y study period. CTPA and V/Q performed comparably for pulmonary embolism diagnosis when the choice of imaging was guided by results of chest radiography. Hence, V/Q is a reasonable first choice for sickle cell disease patients with normal chest radiographs. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Tivnan, P., Billett, H. H., Freeman, L. M., Haramati, L. B. Tags: Clinical Source Type: research

Evaluation of PET Brain Radioligands for Imaging Pancreatic {beta}-Cell Mass: Potential Utility of 11C-(+)-PHNO
Conclusion: 11C-(+)-PHNO is a potential marker of BCM, with 2:1 binding of D3 receptors over D2 receptors. Further in vitro and in vivo studies to establish D2/D3 receptor specificity to β-cells is warranted to characterize 11C-(+)-PHNO as a candidate for clinical measurement of BCM in healthy control and diabetic subjects. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Bini, J., Naganawa, M., Nabulsi, N., Huang, Y., Ropchan, J., Lim, K., Najafzadeh, S., Herold, K. C., Cline, G. W., Carson, R. E. Tags: Translational Source Type: research

Measurement of Brown Adipose Tissue Activity Using Microwave Radiometry and 18F-FDG PET/CT
The aim of this study was to evaluate the operating characteristics of a microwave radiometry system in the noninvasive assessment of activated and nonactivated brown adipose tissue (BAT) and normal-tissue temperatures, reflecting metabolic activity in healthy human subjects. The radiometry data were compared with 18F-FDG PET/CT images in the same subjects. Methods: Microwave radiometry and 18F-FDG PET/CT were sequentially performed on 19 participants who underwent a cold intervention to maximize BAT activation. The cold intervention involved the participants’ intermittently placing their feet on an ice block while s...
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Crandall, J. P., O, J. H., Gajwani, P., Leal, J. P., Mawhinney, D. D., Sterzer, F., Wahl, R. L. Tags: Clinical Source Type: research

Radiolabeled Antibodies Against Mullerian-Inhibiting Substance Receptor, Type II: New Tools for a Theranostic Approach in Ovarian Cancer
Conclusion: Radiolabeled 16F12 could represent a new theranostic tool for small-volume ovarian peritoneal carcinomatosis. Specifically, 213Bi-16F12–based BIP-RIT could be proposed to selected patients as an alternative adjuvant treatment immediately after cytoreductive surgery. An anti-MISRII mAb is currently being used in a first-in-human study, thus making radiolabeled anti-MISRII mAbs a realistic theranostic option for the clinic. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Deshayes, E., Ladjohounlou, R., Le Fur, P., Pichard, A., Lozza, C., Boudousq, V., Sevestre, S., Jarlier, M., Kashani, R., Koch, J., Sosabowski, J., Foster, J., Chouin, N., Bruchertseifer, F., Morgenstern, A., Kotzki, P.-O., Navarro-Teulon, I., Pouget, J.- Tags: Basic Source Type: research

PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression in healthy brain tissue. Paired with the availability of specific small molecule inhibitors, PARP-1 is a near-ideal target to develop novel radiotherapeutics to induce DNA damage and apoptosis in cancer cells, while sparing healthy brain tissue. Methods: We synthesized an 131I-labeled PARP-1 therapeutic and investigated its pharmacology in vitro and in vivo. A subcutaneous tumor model was used to quantify retention times and therapeutic efficacy. A potential clinical scenario, intratumoral convection-e...
Source: Journal of Nuclear Medicine - August 2, 2018 Category: Nuclear Medicine Authors: Jannetti, S. A., Carlucci, G., Carney, B., Kossatz, S., Shenker, L., Carter, L. M., Salinas, B., Brand, C., Sadique, A., Donabedian, P. L., Cunanan, K. M., Gonen, M., Ponomarev, V., Zeglis, B. M., Souweidane, M. M., Lewis, J. S., Weber, W. A., Humm, J. L. Tags: Basic Source Type: research