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Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Tags: Errata Source Type: research

AACR/SNMMI State-of-the-Art Molecular Imaging in Cancer Biology and Therapy: Abstracts
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Tags: Abstract Source Type: research

Reply: Regarding "18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi"
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Stephens, A. Tags: Letters Source Type: research

Regarding "18F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi"
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Alavi, A., Werner, T. J., Hess, S., Hoilund-Carlsen, P. F. Tags: Letters Source Type: research

Reply: DNA Repair After Exposure to Ionizing Radiation Is Not Error-Free
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Siegel, J. A., Sacks, B., Pennington, C. W., Welsh, J. S. Tags: Letters Source Type: research

DNA Repair After Exposure to Ionizing Radiation Is Not Error-Free
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Duncan, J. R., Lieber, M. R., Adachi, N., Wahl, R. L. Tags: Letters Source Type: research

Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Kim, E. E. Tags: Book Reviews Source Type: research

Errata
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Tags: Errata Source Type: research

64Cu-Labeled Repebody Molecules for Imaging of Epidermal Growth Factor Receptor-Expressing Tumors
Conclusion: The 3 64Cu-repebody complexes demonstrated specific and rapid uptake in EGFR-expressing tumors within 1 h and may have potential as novel EGFR imaging agents for PET. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Pyo, A., Yun, M., Kim, H. S., Kim, T.-Y., Lee, J.-j., Kim, J. Y., Lee, S., Kwon, S. Y., Bom, H.-S., Kim, H.-S., Kim, D.-Y., Min, J.-J. Tags: Basic Source Type: research

68Ga-NOTA-Functionalized Ubiquicidin: Cytotoxicity, Biodistribution, Radiation Dosimetry, and First-in-Human PET/CT Imaging of Infections
Ubiquicidin is an antimicrobial peptide with great potential for nuclear imaging of infectious diseases, as its cationic-rich fragment TGRAKRRMQYNRR (UBI) has been functionalized with NOTA to allow complexation to 68Ga (68Ga-NOTA-UBI). We herein assess the cytotoxicity and radiation dosimetry for 68Ga-NOTA-UBI and a first-in-human evaluation to diagnose infectious processes. Methods: Cytotoxicity was evaluated in green monkey kidney epithelial (Vero) cells and MT-4 leukocytes. Tracer susceptibility was studied in vitro using different bacterial and fungal strains. PET/CT-based biodistribution, pharmacokinetics, and radiati...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Ebenhan, T., Sathekge, M. M., Lengana, T., Koole, M., Gheysens, O., Govender, T., Zeevaart, J. R. Tags: Basic Source Type: research

Evaluation of the Lysophosphatidic Acid Receptor Type 1 Radioligand 11C-BMT-136088 for Lung Imaging in Rhesus Monkeys
Conclusion: Specific binding of 11C-BMT-136088 can be reliably measured to quantify LPA1 in the lungs of rhesus monkeys in vivo. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Gallezot, J.-D., Nabulsi, N. B., Holden, D., Lin, S.-F., Labaree, D., Ropchan, J., Najafzadeh, S., Donnelly, D. J., Cao, K., Bonacorsi, S., Seiders, J., Roppe, J., Hayes, W., Huang, Y., Du, S., Carson, R. E. Tags: Translational Source Type: research

68Ga-Pentixafor PET/CT Imaging of Chemokine Receptor CXCR4 in Chronic Infection of the Bone: First Insights
Conclusion: Imaging of CXCR4 expression with 68Ga-pentixafor PET/CT appears suitable for diagnosing chronic infection of the skeleton. The findings of this study reveal a possible diagnostic gain in suspected chronic infections that are difficult to diagnose by other imaging modalities. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Bouter, C., Meller, B., Sahlmann, C. O., Staab, W., Wester, H. J., Kropf, S., Meller, J. Tags: Clinical Source Type: research

Test-Retest Reliability of the SERT Imaging Agent 11C-HOMADAM in Healthy Humans
Conclusion: Good-to-excellent test–retest reliability was observed for SERT binding in the striatum. The dorsal raphe ICC value was sensitive to a measurement outlier. 11C-HOMADAM binding potential calculated from the simplified reference tissue model and the multilinear graphical model were robust and in good agreement. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Adhikarla, V., Dunlop, B. W., Jarkas, N., Goodman, M. M., Mayberg, H., Owens, M. J., Nye, J. A. Tags: Clinical Source Type: research

Impact of Endothelial 18-kDa Translocator Protein on the Quantification of 18F-DPA-714
Conclusion: Accounting for endothelial TSPO in the kinetic model improved the fit of PET data. The high correlation between Kb and TSPO mRNA suggests that the 2TC-1K model reveals more biologic information about the regional density of TSPO than the 2TC. The correlation between TSPO and endothelial cell mRNA supports the relationship between the regional variation of Kb and endothelial TSPO. These results can improve the estimation of binding parameter estimates from 18F-DPA-714 PET, especially in diseases that induce vascular change. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Wimberley, C., Lavisse, S., Brulon, V., Peyronneau, M.-A., Leroy, C., Bodini, B., Remy, P., Stankoff, B., Buvat, I., Bottlaender, M. Tags: Clinical Source Type: research

18F-Flortaucipir PET/MRI Correlations in Nonamnestic and Amnestic Variants of Alzheimer Disease
Conclusion: 18F-flortaucipir binding corresponds to the expected neurodegeneration patterns in nonamnestic AD, with potential for earlier detection of pathology than is possible with MRI atrophy measures. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Nasrallah, I. M., Chen, Y. J., Hsieh, M.-K., Phillips, J. S., Ternes, K., Stockbower, G. E., Sheline, Y., McMillan, C. T., Grossman, M., Wolk, D. A. Tags: Clinical Source Type: research

Brain Perfusion Imaging Under Acetazolamide Challenge for Detection of Impaired Cerebrovascular Reserve Capacity: Positive Findings with 15O-Water PET in Patients with Negative 99mTc-HMPAO SPECT Findings
Conclusion: 15O-water PET enables detection of impaired CVRC in a considerable fraction of symptomatic patients with stenoocclusion and negative 99mTc-HMPAO SPECT. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Acker, G., Lange, C., Schatka, I., Pfeifer, A., Czabanka, M. A., Vajkoczy, P., Buchert, R. Tags: Clinical Source Type: research

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Murthy, V. L., Bateman, T. M., Beanlands, R. S., Berman, D. S., Borges-Neto, S., Chareonthaitawee, P., Cerqueira, M. D., deKemp, R. A., DePuey, E. G., Dilsizian, V., Dorbala, S., Ficaro, E. P., Garcia, E. V., Gewirtz, H., Heller, G. V., Lewin, H. C., Malh Tags: Special Contributions Source Type: research

Clinical Molecular Imaging of Chemokine Receptor CXCR4 Expression in Atherosclerotic Plaque Using 68Ga-Pentixafor PET: Correlation with Cardiovascular Risk Factors and Calcified Plaque Burden
The CXC-motif chemokine receptor 4 (CXCR4) represents a promising target for molecular imaging of different CXCR4-positive cell types in cardiovascular diseases such as atherosclerosis and arterial wall injury. The aim of this study was to assess the prevalence, pattern, and clinical correlates of arterial wall accumulation of 68Ga-pentixafor, a specific CXCR4 ligand for PET. Methods: The data for 51 patients who underwent 68Ga-pentixafor PET/CT for noncardiovascular indications were retrospectively analyzed. Tracer accumulation in the vessel wall of major arteries was analyzed qualitatively and semiquantitatively by blood...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Weiberg, D., Thackeray, J. T., Daum, G., Sohns, J. M., Kropf, S., Wester, H.-J., Ross, T. L., Bengel, F. M., Derlin, T. Tags: Clinical Source Type: research

Prognostic Value of 123I-BMIPP SPECT in Patients with Nonischemic Heart Failure with Preserved Ejection Fraction
This study aimed to evaluate the prognostic value of the 123I-BMIPP defect score in such patients. Methods: Of 804 consecutive patients who were admitted to the hospital because of acute heart failure and underwent 123I-BMIPP SPECT, we identified 133 (mean age ± SD, 73 ± 13 y) who had normal coronary arteries by invasive coronary angiography and preserved left ventricular ejection fraction (≥50%) by echocardiography. 123I-BMIPP defects were quantitatively scored to obtain summed defect scores in 17 segments of 123I-BMIPP SPECT images. The patients were divided into 2 groups based on their score. The multiv...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Hashimoto, H., Nakanishi, R., Mizumura, S., Hashimoto, Y., Okamura, Y., Kiuchi, S., Yamazaki, J., Ikeda, T. Tags: Clinical Source Type: research

Determination of the Heart-to-Mediastinum Ratio of 123I-MIBG Uptake Using Dual-Isotope (123I-MIBG/99mTc-Tetrofosmin) Multipinhole Cadmium-Zinc-Telluride SPECT in Patients with Heart Failure
The aim of this retrospective study was to compare the heart-to-mediastinum ratio (HMR) of 123I-metaiodobenzylguanidine (123I-MIBG) uptake obtained using a multipinhole cadmium–zinc–telluride (CZT) camera with that obtained using conventional planar imaging. Methods: Forty consecutive heart failure patients underwent planar acquisition 4 h after 123I-MIBG injection (191 ± 41 [mean ± SD] MBq). To localize the heart using the CZT camera, 99mTc-tetrofosmin (358 ± 177 MBq) was administered and dual-isotope acquisition was performed. The HMRs were calculated with conventional planar imaging (HMR...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Blaire, T., Bailliez, A., Ben Bouallegue, F., Bellevre, D., Agostini, D., Manrique, A. Tags: Clinical Source Type: research

Targeted Molecular Radiotherapy of Pediatric Solid Tumors Using a Radioiodinated Alkyl-Phospholipid Ether Analog
Conclusion: 131I-CLR1404 has the potential to become a tumor-targeted radiotherapeutic drug with broad applicability in pediatric oncology. Because 131I-CLR1404 has entered clinical trials in adults, our data warrant the development of pediatric clinical trials for this particularly vulnerable patient population. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Baiu, D. C., Marsh, I. R., Boruch, A. E., Shahi, A., Bhattacharya, S., Jeffery, J. J., Zhao, Q., Hall, L. T., Weichert, J. P., Bednarz, B. P., Otto, M. Tags: Basic Source Type: research

Immunohistochemical Validation of PSMA Expression Measured by 68Ga-PSMA PET/CT in Primary Prostate Cancer
68Ga-labeled prostate-specific membrane antigen (68Ga-PSMA) PET/CT has a proven role in staging and restaging of prostate cancer (PCA). The aims of this study were to evaluate the association of intraprostatic 68Ga-PSMA PET/CT findings and PSMA expression in immunohistochemical staining and generate a cutoff value for differentiation between normal prostate (PN) and PCA. Methods: The data of 31 patients (mean age, 67.2 y) who underwent prostatectomy and preoperative PET were retrospectively analyzed. On PET, focally increased uptake in the prostate was suggestive of tumor. A region of interest was placed on the suggestive ...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Woythal, N., Arsenic, R., Kempkensteffen, C., Miller, K., Janssen, J.-C., Huang, K., Makowski, M. R., Brenner, W., Prasad, V. Tags: Translational Source Type: research

68Ga-PSMA-11 PET/CT Mapping of Prostate Cancer Biochemical Recurrence After Radical Prostatectomy in 270 Patients with a PSA Level of Less Than 1.0 ng/mL: Impact on Salvage Radiotherapy Planning
Conclusion: Post hoc analysis of 68Ga-PSMA-11 PET/CT implied a major impact on SRT planning in 52 of 270 patients (19%) with PCa early BCR (PSA
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Calais, J., Czernin, J., Cao, M., Kishan, A. U., Hegde, J. V., Shaverdian, N., Sandler, K., Chu, F.-I., King, C. R., Steinberg, M. L., Rauscher, I., Schmidt-Hegemann, N.-S., Poeppel, T., Hetkamp, P., Ceci, F., Herrmann, K., Fendler, W. P., Eiber, M., Nick Tags: Clinical Source Type: research

PSMA PET: Transformational Change in Prostate Cancer Management?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Jadvar, H., Ballas, L. K. Tags: Clinical Source Type: research

Long-Acting Somatostatin Analog Therapy Differentially Alters 68Ga-DOTATATE Uptake in Normal Tissues Compared with Primary Tumors and Metastatic Lesions
Conclusion: Long-acting octreotide treatment diminished 68Ga-DOTATATE uptake in the liver, spleen, and thyroid but did not compromise tracer uptake in residual primary tumor and metastatic lesions. These findings have a direct impact on the interpretation of 68Ga-DOTATATE PET/CT scans. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Ayati, N., Lee, S. T., Zakavi, R., Pathmaraj, K., Al-Qatawna, L., Poon, A., Scott, A. M. Tags: Clinical Source Type: research

Preclinical Development of CD38-Targeted [89Zr]Zr-DFO-Daratumumab for Imaging Multiple Myeloma
Conclusion: [89Zr]Zr-DFO- and Cy5-daratumumab demonstrated superb binding to CD38+ human MM cells and significantly low binding to CD38low cells. Daratumumab bioconjugates are being evaluated for image-guided delivery of therapeutic radionuclides. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Ghai, A., Maji, D., Cho, N., Chanswangphuwana, C., Rettig, M., Shen, D., DiPersio, J., Akers, W., Dehdashti, F., Achilefu, S., Vij, R., Shokeen, M. Tags: Basic Source Type: research

Dynamic 18F-FDG PET Lymphography for In Vivo Identification of Lymph Node Metastases in Murine Melanoma
Conclusion: In a tumor model, significantly longer retention of the radiotracer during 18F-FDG lymphography was seen in metastatic than nonmetastatic lymph nodes, allowing for differentiation between the two and for selective resection of tumor-bearing nodes using Cerenkov imaging. Inflammation can be better differentiated in a subacute state. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Lockau, H., Neuschmelting, V., Ogirala, A., Vilaseca, A., Grimm, J. Tags: Basic Source Type: research

The Impact of Adding Sentinel Node Biopsy to Extended Pelvic Lymph Node Dissection on Biochemical Recurrence in Prostate Cancer Patients Treated with Robot-Assisted Radical Prostatectomy
Conclusion: Adding SNB to ePLND improves BCR-free survival, although the precise explanation of this observation remains speculative. Our results should be interpreted cautiously, given the nonrandomized nature and the selection bias of the study. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Grivas, N., Wit, E. M. K., Kuusk, T., KleinJan, G. H., Donswijk, M. L., van Leeuwen, F. W. B., van der Poel, H. G. Tags: Clinical Source Type: research

Improved Estrogen Receptor Assessment by PET Using the Novel Radiotracer 18F-4FMFES in Estrogen Receptor-Positive Breast Cancer Patients: An Ongoing Phase II Clinical Trial
Conclusion: This phase II study with ER+ breast cancer patients showed that 18F-4FMFES PET achieves a lower nonspecific signal and better tumor contrast than 18F-FES PET, resulting in improved diagnostic confidence and lower false-negative diagnoses. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Paquette, M., Lavallee, E., Phoenix, S., Ouellet, R., Senta, H., van Lier, J. E., Guerin, B., Lecomte, R., Turcotte, E. E. Tags: Clinical Source Type: research

Early Evaluation of Response Using 18F-FDG PET Influences Management in Gastrointestinal Stromal Tumor Patients Treated with Neoadjuvant Imatinib
18F-FDG PET has previously been proven effective as an early way to evaluate the response of gastrointestinal stromal tumors (GISTs) to imatinib treatment. However, it is unclear whether early evaluation of response affects treatment decisions in GIST patients treated with neoadjuvant intent. Methods: We retrospectively scored changes in management based on early evaluation of response by 18F-FDG PET in patients in the Dutch GIST registry treated with neoadjuvant imatinib. Results: Seventy 18F-FDG PET scans were obtained for 63 GIST patients to evaluate for an early response to neoadjuvant imatinib. The scans led to a chan...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Farag, S., Geus-Oei, L.-F. d., van der Graaf, W. T., van Coevorden, F., Grunhagen, D., Reyners, A. K. L., Boonstra, P. A., Desar, I., Gelderblom, H., Steeghs, N. Tags: Clinical Source Type: research

Responsible Radiomics Research for Faster Clinical Translation
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Vallieres, M., Zwanenburg, A., Badic, B., Cheze Le Rest, C., Visvikis, D., Hatt, M. Tags: Editorials Source Type: research

In Vivo Imaging of Pro- and Antitumoral Cellular Components of the Tumor Microenvironment
Tumor development and growth, as well as metastatic spread, are strongly influenced by various, mostly innate, immune cells, which are recruited to the tumor site and driven to establish a specific tumor-supportive microenvironment. The contents of this microenvironment, such as myeloid cells, are a major factor in the overall prognosis of malignant disease, addressed by a constantly growing armament of therapeutic interventions targeting tumor-supportive immune cells. Current clinical imaging has long ignored the growing need for diagnostic approaches addressing these microenvironmental contents—approaches enabling ...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Helfen, A., Roth, J., Ng, T., Eisenblaetter, M. Tags: Focus on Molecular Imaging Source Type: research

Why Targeting PSMA Is a Game Changer in the Management of Prostate Cancer
Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein that is highly expressed on prostate adenocarcinomas, exhibits only limited expression in benign and extraprostatic tissues, and thus represents an ideal target for the diagnosis and management of prostate cancer. Since its discovery over 30 y ago, significant effort has been made to develop clinical technology targeting PSMA. The last 5 y have seen an explosion of development of new agents targeting PSMA for diagnostic and therapeutic use. Imaging agents targeting PSMA have been developed for SPECT and PET platforms. PSMA PET imaging appears to outp...
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Donin, N. M., Reiter, R. E. Tags: The State of the Art Source Type: research

Selective Tau Imaging: Der Stand der Dinge
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Villemagne, V. L. Tags: Hot Topics Source Type: research

From The Literature
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: Strengthening Outreach to Patients and the Medical Community
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Pappas, V. Tags: SNMMI Newsline Source Type: research

Survey of Programs About the ABR 16-Month Nuclear Radiology Pathway for Diagnostic Radiology Residents
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Harolds, J. A. Tags: SNMMI Newsline Source Type: research

2017 SNMMI Highlights Lecture: Oncology, Part 2
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Authors: Weber, W. Tags: SNMMI Newsline Source Type: research

This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - February 1, 2018 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Tags: Erratum Source Type: research

Design and Applications of Nanoparticles in Biomedical Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Kim, E. E. Tags: Book Reviews Source Type: research

PET Imaging Stability Measurements During Simultaneous Pulsing of Aggressive MR Sequences on the SIGNA PET/MR System
Conclusion: PET stability metrics demonstrated that PET quantitation was not affected during simultaneous aggressive MRI. This stability enables demanding applications such as kinetic modeling. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Deller, T. W., Khalighi, M. M., Jansen, F. P., Glover, G. H. Tags: Physics/Instrumentation Source Type: research

Pharmacokinetics, Biodistribution, and Radiation Dosimetry for 89Zr-Trastuzumab in Patients with Esophagogastric Cancer
Conclusion: 89Zr-trastuzumab imaging tracer is safe and provides high-quality images in patients with HER2-positive EGA, with an optimal imaging time of 5–8 d after injection. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: O'Donoghue, J. A., Lewis, J. S., Pandit-Taskar, N., Fleming, S. E., Schoder, H., Larson, S. M., Beylergil, V., Ruan, S., Lyashchenko, S. K., Zanzonico, P. B., Weber, W. A., Carrasquillo, J. A., Janjigian, Y. Y. Tags: Clinical Source Type: research

RADAR Dose Estimate Report: A Compendium of Radiopharmaceutical Dose Estimates Based on OLINDA/EXM Version 2.0
A compendium of about 100 radiopharmaceuticals, based on the OLINDA/EXM version 2.0 software, is presented. A new generation of voxel-based, realistic human computational phantoms developed by the RADAR committee of the Society of Nuclear Medicine and Molecular Imaging, based on 2007 recommendations of the International Commission on Radiological Protection, was used to develop the dose estimates, and the most recent biokinetic models were used as well. These estimates will be made available in electronic form and can be modified and updated as models are changed and as new radiopharmaceuticals are added. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Stabin, M. G., Siegel, J. A. Tags: Clinical Source Type: research

Biodistribution and Dosimetry of 18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies
Conclusion: Preliminary data show that 18F-MFBG imaging is safe and has favorable biodistribution and kinetics with good targeting of lesions. PET imaging with 18F-MFBG allows for same-day imaging of NETs. 18F-MFBG appears highly promising for imaging of patients with NETs, especially children with neuroblastoma. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Pandit-Taskar, N., Zanzonico, P., Staton, K. D., Carrasquillo, J. A., Reidy-Lagunes, D., Lyashchenko, S., Burnazi, E., Zhang, H., Lewis, J. S., Blasberg, R., Larson, S. M., Weber, W. A., Modak, S. Tags: Clinical Source Type: research

Novel 18F-Labeled {kappa}-Opioid Receptor Antagonist as PET Radiotracer: Synthesis and In Vivo Evaluation of 18F-LY2459989 in Nonhuman Primates
Conclusion: The evaluation of 18F-LY2459989 in nonhuman primates demonstrated many attractive imaging properties: fast tissue kinetics, specific and selective binding to the KOR, and high specific binding signals. A side-by-side comparison of 18F-LY2459989 and 11C-LY2459989 indicated similar kinetic and binding profiles for the 2 radiotracers. Taken together, the results indicated that 18F-LY2459989 appears to be an excellent PET radiotracer for the imaging and quantification of the KOR in vivo. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Li, S., Cai, Z., Zheng, M.-Q., Holden, D., Naganawa, M., Lin, S.-F., Ropchan, J., Labaree, D., Kapinos, M., Lara-Jaime, T., Navarro, A., Huang, Y. Tags: Basic Source Type: research

Validation of 2-18F-Fluorodeoxysorbitol as a Potential Radiopharmaceutical for Imaging Bacterial Infection in the Lung
Conclusion: Uptake of both 18F-FDS and 18F-FDG in infected lung could be used to track the degree of bacterial infection measured by BLI, with a minimum detection limit of 107 bacteria. 18F-FDS, however, is more specific than 18F-FDG in differentiating K. pneumoniae lung infection from lung inflammation. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Li, J., Zheng, H., Fodah, R., Warawa, J. M., Ng, C. K. Tags: Basic Source Type: research

The Value of 18F-FDG PET/CT in Diagnosis and During Follow-up in 273 Patients with Chronic Q Fever
Conclusion: 18F-FDG PET/CT is a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change in diagnosis or treatment modification and providing important prognostic information on patient survival. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - January 2, 2018 Category: Nuclear Medicine Authors: Kouijzer, I. J. E., Kampschreur, L. M., Wever, P. C., Hoekstra, C., van Kasteren, M. E. E., de Jager-Leclercq, M. G. L., Nabuurs-Franssen, M. H., Wegdam-Blans, M. C. A., Ammerlaan, H. S. M., Buijs, J., Geus-Oei, L.-F. d., Oyen, W. J. G., Bleeker-Rovers, C Tags: Clinical Source Type: research