Aruna Bodapati Gambhir, 1962-2023
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Behrenbruch, C., Iagaru, A., James, M. L. Tags: In Memoriam Source Type: research

Reply: [18F]FDG and Lymphomas: Still a Winning Golden Couple in the Era of FAPI-Based Radiotracers
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Chen, X., Wang, X. Tags: Letters Source Type: research

Commentary on "Radioactive Iodine: A Living History"
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Greenspan, B. S., Hofman, M. S., Buscombe, J. Tags: Letters Source Type: research

[18F]FDG and Lymphomas: Still a Winning Golden Couple in the Era of FAPI-Based Radiotracers
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Guglielmo, P., Evangelista, L. Tags: Letters Source Type: research

CCK2 Receptor-Targeted PET/CT in Medullary Thyroid Cancer Using [68Ga]Ga-DOTA-CCK-66
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Viering, O., Gunther, T., Holzleitner, N., Dierks, A., Wienand, G., Pfob, C. H., Bundschuh, R. A., Wester, H.-J., Enke, J. S., Kircher, M., Lapa, C. Tags: The Illustrated Post Source Type: research

Need for Objective Task-Based Evaluation of Image Segmentation Algorithms for Quantitative PET: A Study with ACRIN 6668/RTOG 0235 Multicenter Clinical Trial Data
Conclusion: Evaluation of PET segmentation algorithms using task-agnostic FoMs could yield findings discordant with evaluation on clinically relevant quantitative tasks. This study emphasizes the need for objective task-based evaluation of image segmentation algorithms for quantitative PET. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Liu, Z., Mhlanga, J. C., Xia, H., Siegel, B. A., Jha, A. K. Tags: AI/Advanced Image Analysis Source Type: research

Preclinical Evaluation of Gastrin-Releasing Peptide Receptor Antagonists Labeled with 161Tb and 177Lu: A Comparative Study
Conclusion: On the basis of preclinical results, [161Tb]Tb-/[177Lu]Lu-AMTG might reveal a higher therapeutic efficacy than [161Tb]Tb-/[177Lu]Lu-RM2, particularly [161Tb]Tb-AMTG because of additional Auger-electron emissions at the cell membrane level. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Holzleitner, N., Cwojdzinski, T., Beck, R., Urtz-Urban, N., Hillhouse, C. C., Grundler, P. V., van der Meulen, N. P., Talip, Z., Ramaekers, S., Van de Voorde, M., Ponsard, B., Casini, A., Gunther, T. Tags: Brief Communications Source Type: research

Its a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET
Conclusion: Our study highlights the significance of aldolase-guided C4 radiodeoxyfluorination of fructose in enabling effective radiotracer trapping, overcoming limitations of C1 and C6 radioanalogs toward a clinically viable tool for imaging fructolysis in highly glycolytic tissues. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Kirby, A., Graf, D., Suchy, M., Calvert, N. D., Charlton, T. A., Ben, R. N., Addison, C. L., Shuhendler, A. Tags: Featured Basic Science Article Source Type: research

Triggered Seizures for Ictal SPECT Imaging: A Case Series and Feasibility Study
Conclusion: Triggering of seizures for ictal SPECT complements discrete sEEG sampling with spatially complete images of early seizure propagation. This readily implementable method revives interest in seizure imaging to guide resective epilepsy surgery. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Barlatey, S. L., Mignardot, C. G., Friedrichs-Maeder, C., Schindler, K., Wiest, R., Nowacki, A., Haenggi, M., ZGraggen, W. J., Pollo, C., Rominger, A., Pyka, T., Baud, M. O. Tags: Brief Communications Source Type: research

First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding
Conclusion: 18F-SynVesT-2 has fast kinetics, high specific uptake, and low nonspecific uptake in the brain. Consistent with the nonhuman primate results, the kinetics of 18F-SynVesT-2 is faster than the kinetics of 11C-UCB-J and 18F-SynVesT-1 in the human brain and enables a shorter dynamic scan to derive physiologic information on cerebral blood flow and synapse density. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Drake, L. R., Wu, Y., Naganawa, M., Asch, R., Zheng, C., Najafzadeh, S., Pracitto, R., Lindemann, M., Li, S., Ropchan, J., Labaree, D., Emery, P. R., Dias, M., Henry, S., Nabulsi, N., Matuskey, D., Hillmer, A. T., Gallezot, J.-D., Carson, R. E., Cai, Z., Tags: Clinical Investigations Source Type: research

One-Year Longitudinal Changes in Tau Accumulation on [18F]PI-2620 PET in the Alzheimer Spectrum
Conclusion: These findings suggest that [18F]PI-2620 PET can be a biomarker to provide regional and chronologic information about tau pathology in the AD continuum. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Oh, M., Oh, S. J., Lee, S. J., Oh, J. S., Seo, S. Y., Ryu, S., Roh, J. H., Lee, J.-H., Kim, J. S. Tags: Clinical Investigations Source Type: research

Dopamine Transporter SPECT with 12-Minute Scan Duration Using Multiple-Pinhole Collimators
Conclusion: The triple-head SPECT system with MPH collimators allows reliable DAT SPECT after administration of about 180 MBq of [123I]FP-CIT with a 12-min scan duration. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Buchert, R., Szabo, B., Kovacs, A., Buddenkotte, T., Mathies, F., Karimzadeh, A., Lehnert, W., Klutmann, S., Forgacs, A., Apostolova, I. Tags: Clinical Investigations Source Type: research

Differences and Common Ground in 177Lu-PSMA Radioligand Therapy Practice Patterns: International Survey of 95 Theranostic Centers
Conclusion: Results from this international survey revealed interinstitutional differences in several aspects of 177Lu-PSMA radionuclide therapy, including patient selection, administered activity, and the response assessment strategy. Standardization or harmonization of protocols and dedicated training are desirable in anticipation of increasing numbers of patients and theranostic centers. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Farolfi, A., Armstrong, W. R., Djaileb, L., Gafita, A., Hotta, M., Allen-Auerbach, M., Unterrainer, L. M., Fendler, W. P., Rettig, M., Eiber, M., Hofman, M. S., Hadaschik, B., Herrmann, K., Czernin, J., Calais, J., Benz, M. R. Tags: Clinical Investigations Source Type: research

First Safety and Efficacy Data with the Radiohybrid 177Lu-rhPSMA-10.1 for the Treatment of Metastatic Prostate Cancer
Conclusion: 177Lu-rhPSMA-10.1 demonstrated encouraging preliminary efficacy and was well tolerated. Formal clinical trials are now under way to evaluate its potential prospectively (NCT05413850). (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Dierks, A., Gable, A., Rinscheid, A., Wienand, G., Pfob, C. H., Kircher, M., Enke, J. S., Janzen, T., Patt, M., Trepel, M., Weckermann, D., Bundschuh, R. A., Lapa, C. Tags: Clinical Investigations Source Type: research

The DETECT Trial: Are We on the Verge of Precision Surgery in Primary Prostate Cancer?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Maurer, T., Thomas, C., Hadaschik, B. Tags: INVITED PERSPECTIVE Source Type: research