Reply: Diversity, Not Divisiveness, Is the Future of Nuclear Medicine
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Czernin, J. Tags: Letters Source Type: research

Diversity, Not Divisiveness, Is the Future of Nuclear Medicine
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Noto, R. B. Tags: Letters Source Type: research

Appropriate Use Criteria for PET Myocardial Perfusion Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Schindler, T. H., Bateman, T. M., Berman, D. S., Chareonthaitawee, P., De Blanche, L. E., Dilsizian, V., Dorbala, S., Gropler, R. J., Shaw, L., Soman, P., Winchester, D. E., Verberne, H., Ahuja, S., Beanlands, R. S., Di Carli, M. F., Murthy, V. L., Ruddy, Tags: Special Contributions Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: Erratum Source Type: research

Evaluation of 11C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats
Conclusion: 11C-(S)-NR2B-SMe has adequate NR2B-specific PET signal in rat brain to warrant further evaluation in higher species. TC1 and SA4503 likely have off-target binding to NR2B in vivo. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C. L., Telu, S., Davies, R., Frankland, M. P., Zoghbi, S. S., Cheng, K., Hall, M. D., Innis, R. B., Pike, V. W. Tags: Basic Source Type: research

Initial Clinical Results of a Novel Immuno-PET Theranostic Probe in Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer
Conclusion: Immuno-PET using anti-CEA/anti-IMP288 bispecific antibody, followed by 68Ga-IMP288, is a potentially sensitive theranostic imaging method for HER2-negative, CEA-positive metastatic breast cancer patients and warrants further research. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Rousseau, C., Goldenberg, D. M., Colombie, M., Sebille, J.-C., Meingan, P., Ferrer, L., Baumgartner, P., Cerato, E., Masson, D., Campone, M., Rauscher, A., Fleury, V., Labbe, C., Chauvet, A. F., Fresnel, J.-S., Toquet, C., Barbet, J., Sharkey, R. M., Camp Tags: Clinical Source Type: research

Tobacco Smoking in People Is Not Associated with Altered 18-kDa Translocator Protein Levels: A PET Study
Conclusion: These findings inform previous PET studies reporting lower TSPO radiotracer concentrations in the brain (measured as SUV) for tobacco smokers than for nonsmokers by demonstrating the importance of accounting for radiotracer concentrations in plasma. These findings suggest that nonsmokers and smokers have comparable TSPO levels in the brain. Additional work with other biomarkers is needed to fully characterize the effects of tobacco smoking on the brain immune system. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Hillmer, A. T., Matuskey, D., Huang, Y., Nabulsi, N., Ropchan, J., Carson, R. E., OMalley, S. S., Cosgrove, K. P. Tags: Clinical Source Type: research

18F-FDG PET Identifies Altered Brain Metabolism in Patients with Cri du Chat Syndrome
Cri du chat syndrome (CDCS) is a rare genetic disease that is caused by a deletion in the short arm of chromosome 5 (5p) and has a variable clinical spectrum. To our knowledge, no study in the literature has ever applied 18F-FDG PET/CT to investigate alterations in brain glucose metabolism in these subjects. The aims of this study were to detect differences in brain 18F-FDG metabolism in CDCS patients with different clinical presentations and identify possible brain metabolic phenotypes of this syndrome. Methods: Six patients (5 male and 1 female; age range, 10–27 y) with CDCS were assessed for the presence of cognit...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Cistaro, A., Quartuccio, N., Piccardo, A., Fania, P., Spunton, M., Liava, A., Danesino, C., Albani, G., Guala, A. Tags: Clinical Source Type: research

177Lu-NM600 Targeted Radionuclide Therapy Extends Survival in Syngeneic Murine Models of Triple-Negative Breast Cancer
Conclusion: Overall, our results suggest that 177Lu-NM600 targeted radionuclide therapy has potential for TNBC and merits further exploration in a clinical setting. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Hernandez, R., Grudzinski, J. J., Aluicio-Sarduy, E., Massey, C. F., Pinchuk, A. N., Bitton, A. N., Patel, R., Zhang, R., Rao, A. V., Iyer, G., Engle, J. W., Weichert, J. P. Tags: Basic Source Type: research

What You See Is Not What You Get: On the Accuracy of Voxel-Based Dosimetry in Molecular Radiotherapy
Conclusion: Our study showed that 177Lu quantitative SPECT/CT imaging leads to voxel-based dose distributions largely differing from the real organ distribution. SPECT/CT imaging and reconstruction deficiencies might directly translate into unrealistic absorbed dose distributions, thus questioning the reliability of SPECT-based voxel-level dosimetry. Therefore, SPECT/CT reconstructions should be adapted to ensure an accurate quantification of the underlying activity and, therefore, absorbed dose in a volume of interest of the expected object size (e.g., organs, organ substructures, lesions, or voxels). As an example, PETPV...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Tran-Gia, J., Salas-Ramirez, M., Lassmann, M. Tags: Clinical Source Type: research

Radiation Dosimetry and Biodistribution of 68Ga-FAPI-46 PET Imaging in Cancer Patients
Conclusion: 68Ga-FAPI-46 PET/CT has a favorable dosimetry profile, with an estimated whole-body dose of 5.3 mSv for an administration of 200 MBq (5.4 mCi) of 68Ga-FAPI-46 (1.56 ± 0.26 mSv from the PET tracer and 3.7 mSv from 1 low-dose CT scan). The biodistribution study showed high TBRs increasing over time, suggesting high diagnostic performance and favorable tracer kinetics for potential therapeutic applications. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Meyer, C., Dahlbom, M., Lindner, T., Vauclin, S., Mona, C., Slavik, R., Czernin, J., Haberkorn, U., Calais, J. Tags: Clinical Source Type: research

Management of Patients with Renal Failure Undergoing Dialysis During 131I Therapy for Thyroid Cancer
Conclusion: In hemodialysis patients with thyroid cancer, an 131I activity approximately 30% lower than the nominal dose appears to strike an appropriate balance between absence of BM toxicity and therapeutic efficacy. To avoid overirradiation, we recommend pretherapeutic dosimetry studies for metastatic patients to calculate the amount of activity to be administered. We also recommend dosimetry monitoring during the hemodialysis sessions performed after therapeutic dose administration and under the same conditions. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Vermandel, M., Debruyne, P., Beron, A., Devos, L., Talbot, A., Legrand, J.-F., Provot, F., Lion, G. Tags: Clinical Source Type: research

Impact of 68Ga-PSMA-11 PET/CT on Staging and Management of Prostate Cancer Patients in Various Clinical Settings: A Prospective Single-Center Study
Conclusion: PSMA PET/CT has a profound impact on stage and management of PCa patients outside the 2 main classic indications (BCR and presurgical staging) across all examined clinical scenarios. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Sonni, I., Eiber, M., Fendler, W. P., Alano, R. M., Vangala, S. S., Kishan, A. U., Nickols, N., Rettig, M. B., Reiter, R. E., Czernin, J., Calais, J. Tags: Clinical Source Type: research

Quantitative Test-Retest Measurement of 68Ga-PSMA-HBED-CC in Tumor and Normal Tissue
Conclusion: Repeatability measurements for PET/CT test–retests with 68Ga-PSMA-HBED-CC showed a wCV of 12%–14% SUVmax and an RC of ±33%–38% SUVmax in bone and nodal lesions. These estimates are an important aspect of 68Ga-PSMA-HBED-CC as a quantitative imaging biomarker. These estimates are similar to those reported for 18F-FDG, suggesting that 68Ga-PSMA-HBED-CC PET/CT may be useful in monitoring response to therapy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Pollard, J. H., Raman, C., Zakharia, Y., Tracy, C. R., Nepple, K. G., Ginader, T., Breheny, P., Sunderland, J. J. Tags: Clinical Source Type: research

Immune Checkpoint Imaging in Oncology: A Game Changer Toward Personalized Immunotherapy?
Immune checkpoint blockade represents a promising approach in oncology, showing antitumor activities in various cancers. However, although being generally far better tolerated than classic cytotoxic chemotherapy, this treatment, too, may be accompanied by considerable side effects and not all patients benefit equally. Therefore, careful patient selection and monitoring of the treatment response is mandatory. At present, checkpoint-specific molecular imaging is being increasingly investigated as a tool for patient selection and response evaluation. Here, an overview of the current developments in immune checkpoint imaging i...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Lutje, S., Feldmann, G., Essler, M., Brossart, P., Bundschuh, R. A. Tags: Basic Source Type: research

PET/MRI Versus PET/CT for Whole-Body Staging: Results from a Single-Center Observational Study on 1,003 Sequential Examinations
Our purpose was to investigate differences between PET/MRI and PET/CT in lesion detection and classification in oncologic whole-body examinations and to investigate radiation exposure differences between the 2 modalities. Methods: In this observational single-center study, 1,003 oncologic examinations (918 patients; mean age, 57.8 ± 14.4 y) were included. Patients underwent PET/CT and subsequent PET/MRI (149.8 ± 49.7 min after tracer administration). Examinations were reviewed by radiologists and nuclear medicine physicians in consensus. Additional findings, characterization of indeterminate findings on PET/C...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Martin, O., Schaarschmidt, B. M., Kirchner, J., Suntharalingam, S., Grueneisen, J., Demircioglu, A., Heusch, P., Quick, H. H., Forsting, M., Antoch, G., Herrmann, K., Umutlu, L. Tags: Clinical Source Type: research

Positron Lymphography via Intracervical 18F-FDG Injection for Presurgical Lymphatic Mapping in Cervical and Endometrial Malignancies
Conclusion: This first-in-humans study of PLG in women with uterine and cervical cancer demonstrates its feasibility and its ability to identify patients with nodal metastases and warrants further evaluation in additional studies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Mueller, J. J., Dauer, L. T., Murali, R., Iasonos, A., Pandit-Taskar, N., Abu-Rustum, N. R., Grimm, J. Tags: Clinical Source Type: research

Repurposing Molecular Imaging and Sensing for Cancer Image-Guided Surgery
Gone are the days when medical imaging was used primarily to visualize anatomic structures. The emergence of molecular imaging (MI), championed by radiolabeled 18F-FDG PET, has expanded the information content derived from imaging to include pathophysiologic and molecular processes. Cancer imaging, in particular, has leveraged advances in MI agents and technology to improve the accuracy of tumor detection, interrogate tumor heterogeneity, monitor treatment response, focus surgical resection, and enable image-guided biopsy. Surgeons are actively latching on to the incredible opportunities provided by medical imaging for pre...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Mondal, S. B., OBrien, C. M., Bishop, K., Fields, R. C., Margenthaler, J. A., Achilefu, S. Tags: The state of the art Source Type: research

Neuroinflammation PET Imaging: Current Opinion and Future Directions
Neuroinflammation is a key pathologic hallmark of numerous neurologic diseases, however, its exact role in vivo is yet to be fully understood. PET imaging enables investigation, quantification, and tracking of different neuroinflammation biomarkers in living subjects longitudinally. One such biomarker that has been imaged extensively using PET is translocator protein 18 kDa (TSPO). Although imaging TSPO has yielded valuable clinical data linking neuroinflammation to various neurodegenerative diseases, considerable limitations of TSPO PET have prompted identification of other more cell-specific and functionally relevant bio...
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Jain, P., Chaney, A. M., Carlson, M. L., Jackson, I. M., Rao, A., James, M. L. Tags: Focus on Molecular Imaging Source Type: research

Exploiting the Full Potential of {beta}-Amyloid and Tau PET Imaging for Drug Efficacy Testing
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Barthel, H., Seibyl, J., Lammertsma, A. A., Villemagne, V. L., Sabri, O. Tags: Hot Topics Source Type: research

The Impact of COVID-19 on the Health-Care Workforce: from Heroes to Zeroes?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Czernin, J. Tags: Hot Topics Source Type: research

Reply: COVID-19 and Pulmonary Embolism: Diagnostic Imaging Trends
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Zuckier, L. S., Moadel, R. M., Haramati, L. B., Freeman, L. Tags: Covid Commentaries Source Type: research

COVID-19 and Pulmonary Embolism: Diagnostic Imaging Trends
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Karimzadeh, S., Raut, A., Huy, N. T. Tags: Covid Commentaries Source Type: research

Overcoming the COVID-19 Crisis and Planning for the Future
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: LoGiudice, S. H., Liebhaber, A., Schoder, H. Tags: Covid Commentaries Source Type: research

Peptide Receptor Radionuclide Therapy During the COVID-19 Pandemic: Are There Any Concerns?
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Bodei, L., Bergsland, E., de Herder, W. W., Ferone, D., Hicks, R. J., Hope, T. A., Kunikowska, J., Pavel, M., Reidy-Lagunes, D., Siveke, J., Strosberg, J., Dittmer, U., Herrmann, K. Tags: Covid Commentaries Source Type: research

A Conversation Between Kelsey Martin and Johannes Czernin
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Martin, K. C., Czernin, J. Tags: Discussions with Leaders Source Type: research

A Conversation Between Christoph Zindel and Ken Herrmann
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Zindel, C., Herrmann, K. Tags: Discussions with Leaders Source Type: research

The Future of Nuclear Medicine Depends on the Quality of Its Research: Researchers at the University of Heidelberg Receive the Award for Best Article of the Year
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Czernin, J. Tags: Editor ' s Page Source Type: research

Newsbriefs
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Leadership Update: SNMMI Virtual Meeting a Real-Life Success
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Pappas, V. Tags: SNMMI Newsline Source Type: research

In Memoriam: Gerd Muehllehner, PhD 1939-2020
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Authors: Karp, J., Mankoff, D. Tags: SNMMI Newsline Source Type: research

Stephen L. Bacharach, PhD, Honored with SNMMI de Hevesy Award
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Anderson Recognized with SNMMI 2020 Aebersold Award
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

Conti Receives Benedict Cassen Prize for Cancer Imaging Research
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

New Officers for SNMMI and SNMMI-TS
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

SNMMI Newsline
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

JNM Impact Factor Rises to New High
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

2020 SNMMI Image of the Year
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: SNMMI Newsline Source Type: research

This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 3, 2020 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research

Label-Free Visualization of Early Cancer Hepatic Micrometastasis and Intraoperative Image-Guided Surgery by Photoacoustic Imaging
The detection of cancer micrometastasis for early diagnosis and treatment poses a great challenge for conventional imaging techniques. The aim of our study was to evaluate the performance of photoacoustic imaging (PAI) in detecting hepatic micrometastases from melanoma at a very early stage and in aiding tumor resection by intraoperative guidance. Methods: In vivo studies were performed by following protocols approved by the Ethical Committee for Animal Research at Xiamen University. First, a mouse model of B16 melanoma metastatic to the liver (n = 10) was established to study the development of micrometastases in vivo. Ne...
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Yu, Q., Huang, S., Wu, Z., Zheng, J., Chen, X., Nie, L. Tags: Basic Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Tags: Erratum Source Type: research

Light-Induced Radiosynthesis of 89Zr-DFO-Azepin-Onartuzumab for Imaging the Hepatocyte Growth Factor Receptor
Conclusion: The experiments demonstrated that photoradiosynthesis is a viable alternative approach for producing 89Zr-radiolabeled antibodies directly in protein formulation buffer, reducing protein aggregation and liver uptake. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Klingler, S., Fay, R., Holland, J. P. Tags: Basic Source Type: research

Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Tags: Erratum Source Type: research

Targeted Optical Imaging of the Glucagonlike Peptide 1 Receptor Using Exendin-4-IRDye 800CW
Conclusion: These data provide the first in vivo evidence of the feasibility of targeted fluorescence imaging of GLP-1R–positive lesions. Intraoperative lesion delineation using exendin-4-IRDye 800CW could benefit open as well as laparoscopic surgical procedures for removal of insulinomas and focal lesions in CHI. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Boss, M., Bos, D., Frielink, C., Sandker, G., Ekim, S., Marciniak, C., Pattou, F., van Dam, G., van Lith, S., Brom, M., Gotthardt, M., Buitinga, M. Tags: Basic Source Type: research

212Pb {alpha}-Radioimmunotherapy Targeting CD38 in Multiple Myeloma: A Preclinical Study
Conclusion: These results showed 212Pb-daratumumab to have efficacy in xenografted mice, with significant tumor regression and increased survival. This study highlights the potency of α-RIT in MM treatment. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Quelven, I., Monteil, J., Sage, M., Saidi, A., Mounier, J., Bayout, A., Garrier, J., Cogne, M., Durand-Panteix, S. Tags: Basic Source Type: research

Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a {beta}-Amyloidosis Mouse Model with 11C-Metoclopramide PET
Conclusion: 11C-metoclopramide can measure ABCB1 induction in the mouse brain without the need to consider an arterial input function and may find potential application in Alzheimer disease patients to noninvasively evaluate strategies to enhance the clearance properties of the BBB. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Zoufal, V., Mairinger, S., Brackhan, M., Krohn, M., Filip, T., Sauberer, M., Stanek, J., Wanek, T., Tournier, N., Bauer, M., Pahnke, J., Langer, O. Tags: Basic Source Type: research

Individual Mapping of Innate Immune Cell Activation Is a Candidate Marker of Patient-Specific Trajectories of Worsening Disability in Multiple Sclerosis
Our objective was to develop a novel approach to generate individual maps of white matter (WM) innate immune cell activation using 18F-DPA-714 translocator protein PET and to explore the relationship between these maps and individual trajectories of worsening disability in patients with multiple sclerosis (MS). Methods: Patients with MS (n = 37), whose trajectories of worsening disability over the 2 y preceding study entry were calculated, and healthy controls (n = 19) underwent MRI and 18F-DPA-714 PET. A threshold for significant activation of 18F-DPA-714 binding was calculated with a voxelwise randomized permutation-base...
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Bodini, B., Poirion, E., Tonietto, M., Benoit, C., Palladino, R., Maillart, E., Portera, E., Battaglini, M., Bera, G., Kuhnast, B., Louapre, C., Bottlaender, M., Stankoff, B. Tags: Clinical Source Type: research

Mapping Prostate Cancer Lesions Before and After Unsuccessful Salvage Lymph Node Dissection Using Repeat PSMA PET
Conclusion: SLND of pelvic nodal metastases was often not complete according to PSMA PET. About two thirds of patients had PET-positive nodal disease after SLND already seen on pre-SLND PSMA PET. Notably, about one quarter of patients had new lesions, not detected by presurgical PSMA PET. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Farolfi, A., Ilhan, H., Gafita, A., Calais, J., Barbato, F., Weber, M., Afshar-Oromieh, A., Spohn, F., Wetter, A., Rischpler, C., Hadaschik, B., Pianori, D., Fanti, S., Haberkorn, U., Eiber, M., Herrmann, K., Fendler, W. P. Tags: Clinical Source Type: research

Radiation Dosimetry in 177Lu-PSMA-617 Therapy Using a Single Posttreatment SPECT/CT Scan: A Novel Methodology to Generate Time- and Tissue-Specific Dose Factors
Conclusion: This work demonstrates a means for efficient dose estimation in 177Lu-PSMA-617 therapy. By providing methods to simplify and potentially automate radiation dosimetry, we hope to accelerate the understanding of radiobiology and development of dose–response models in this unique therapeutic context. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Jackson, P. A., Hofman, M. S., Hicks, R. J., Scalzo, M., Violet, J. Tags: Clinical Source Type: research

Will SPECT/CT Cameras Soon Be Able to Display Absorbed Doses? Dosimetry from Single-Activity-Concentration Measurements
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - July 1, 2020 Category: Nuclear Medicine Authors: Hanscheid, H., Lassmann, M. Tags: Clinical Source Type: research