Its a Trap! Aldolase-Prescribed C4 Deoxyradiofluorination Affords Intracellular Trapping and the Tracing of Fructose Metabolism by PET

Conclusion: Our study highlights the significance of aldolase-guided C4 radiodeoxyfluorination of fructose in enabling effective radiotracer trapping, overcoming limitations of C1 and C6 radioanalogs toward a clinically viable tool for imaging fructolysis in highly glycolytic tissues.

Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Kirby, A., Graf, D., Suchy, M., Calvert, N. D., Charlton, T. A., Ben, R. N., Addison, C. L., Shuhendler, A. Tags: Featured Basic Science Article Source Type: research