NHS staff say ‘ #OneTeam2K ’ as they call for a pay rise
Health workers deserve more than applause for their efforts – not least during the coronavirus pandemic. That’s why, yesterday and today, staff in UNISON branches based in NHS hospitals, ambulance stations and clinics are holding socially distanced events and using social media to call for a proper pay rise. UNISON’s pay claim, which was delivered to Downing Street last month, would see every NHS employee receive an increase of at least £2,000 by the end of the year. This early wage increase – equivalent to around £1 an hour extra for all staff – could give ailing local economies a...
Source: UNISON Health care news - September 18, 2020 Category: UK Health Authors: Janey Starling Tags: Article News #OneTeam2K Covid-19 health care nhs pay Source Type: news

Expanded Medicaid tied to more thyroid cancer diagnoses
Expanded Medicaid coverage was linked to the diagnosis of more thyroid cancer...Read more on AuntMinnie.comRelated Reading: Some cancers found earlier after Medicaid expansion Medicaid expansion tied to early breast cancer diagnosis Medicaid expansion under ACA linked to fewer cancer deaths Is thyroid cancer overdiagnosed for 9/11 first responders? Medicaid expansion boosted cancer screening rates (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 18, 2020 Category: Radiology Source Type: news

Novel Calculator Predicts Cancer Risk in Patients With CVD Novel Calculator Predicts Cancer Risk in Patients With CVD
An easy-to-use predictive model can estimate 10-year and lifetime risk for cancer in patients with established cardiovascular disease (CVD), new research shows.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - September 18, 2020 Category: Cancer & Oncology Tags: Cardiology News Source Type: news

Immunotherapy improves survival in advanced bladder cancer patients
(Queen Mary University of London) An immunotherapy drug called 'avelumab' has been shown to significantly improve survival in patients with the most common type of bladder cancer, according to results from a phase III clinical trial led by Queen Mary University of London and Barts Cancer Centre, UK. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 18, 2020 Category: International Medicine & Public Health Source Type: news

Increasing the effectiveness of cancer treatments: Anti-PD-L1 immunotherapy
(Tokyo Medical and Dental University) Researh teams of Tokyo Medical and Dental University (TMDU) and Harvard Medical School (HMS) have uncovered how to increase the efficacy of anti-PD-L1 immunotherapy. Using a combination of molecular, biochemical, and bioinformatics approaches, they discovered that the nuclear localization of PD-L1 is controlled by acetylation at a single, specific, Lys site. In the nucleus, PD-L1 controls the expression of immune related genes. Therefore, targeting PD-L1 nuclear localization could enhance the efficacy of PD-1/PD-L1 blockade based immunotherapies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 18, 2020 Category: Biology Source Type: news

New way to halt leukemia relapse shown promising in mice
(Hiroshima University) Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. But drug resistance can occur, leading to relapses. Targeting the lipids involved in regulating part of a leukemia stem cell's life span offers a potential second route to defeat the disease--and solid tumorous cancers as well. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 18, 2020 Category: Biology Source Type: news

Embattled biotech CEO touts potential HIV, Covid treatment as losses and accusations swirl
Nader Pourhassan is a relentless promoter of what he believes will be a game-changing therapy for HIV, cancer, Covid and more. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 18, 2020 Category: Biotechnology Authors: Elizabeth Hayes Source Type: news

Coffee May Slow Spread of Colon Cancer
Of the nearly 1,200 patients in the study, those who drank four or more cups of java on a daily basis had 36% higher odds of surviving during the 13-year study period. (Source: WebMD Health)
Source: WebMD Health - September 17, 2020 Category: Consumer Health News Source Type: news

PET/MRI boosts cancer detection
PET/MRI helps clinicians stage cancer treatment as well as PET/CT -- and finds...Read more on AuntMinnie.comRelated Reading: PET/MRI ups lesion detection by 15% for some cancers SNMMI 2020: PET/MRI finds location of chronic pain in patients SNMMI 2020: PET/MRI combo tracks osteoarthritis progression PET, MRI uncover women's predisposition to Alzheimer's PET/MRI shows inflammation link to mitral valve prolapse (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2020 Category: Radiology Source Type: news

17.09.20: ESMO Virtual Congress 2020:
New data reinforce strong clinical profile of Vitrakvi™ for patients of all ages with TRK Fusion Cancer including lung and thyroid tumors78% overall response rate (ORR) and median progression-free survival (PFS) of more than 3 years (36.8 months) demonstrate extended benefit in updated data set of 175 adults and children / Majority of adverse events were grade 1 or 2; no new safety signals identified / Consistently high ORRs shown in lung and thyroid data subsets (71 and 75%, respectively) as well as long durability (estimated duration of response at 12 months of 88% and 95%, respectively) / Among patients from integ...
Source: Bayer IR Newsfeed: Events - September 17, 2020 Category: Pharmaceuticals Source Type: news

Coffee Linked to Reduced Disease Progression, Death in CRC
THURSDAY, Sept. 17, 2020 -- For patients with advanced or metastatic colorectal cancer (CRC), coffee consumption is associated with reduced risk of disease progression and death, according to a study published online Sept. 17 in JAMA... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2020 Category: Pharmaceuticals Source Type: news

iCAD touts ProFound AI Risk clinical data
Computer-aided detection (CAD) software developer iCAD is highlighting research...Read more on AuntMinnie.comRelated Reading: iCAD reports Xoft Axxent milestone iCAD features AI software for breast imaging at RSNA iCAD features Xoft Axxent upgrades at ASTRO 2019 iCAD partners with Swedish team on AI for breast cancer iCAD to highlight AI for tomosynthesis at ECR (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2020 Category: Radiology Source Type: news

Ovarian cancer symptoms: The ‘patchy’ rash on your skin you should never ignore
OVARIAN CANCER symptoms may be difficult to spot in its early stages, but can include stomach bloating and passing more urine than normal. You could also be at risk of ovarian cancer if you develop this unusual rash on your skin. Should you consider speaking to a doctor? (Source: Daily Express - Health)
Source: Daily Express - Health - September 17, 2020 Category: Consumer Health News Source Type: news

Coffee May Slow Spread of Colon Cancer
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 17, 2020 Category: Cancer & Oncology Tags: Family Medicine, Gastroenterology, Oncology, News, Source Type: news

Cancer Incidence Up for Adolescents and Young Adults
2007 to 2016 saw increase in overall cancer incidence in all age groups, mainly driven by thyroid cancer (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 17, 2020 Category: Cancer & Oncology Tags: Dermatology, Endocrinology, Family Medicine, Gastroenterology, Gynecology, Internal Medicine, Nephrology, Nursing, Oncology, Pediatrics, Journal, Source Type: news

Cancers Associated with Human Papillomavirus in American Indian and Alaska Native Populations - United States, 2013-2017
This report describes incidence of human papillomavirus--associated cancers in American Indian and Alaska Native populations in the United States during 2013-2017. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - September 17, 2020 Category: American Health Tags: American Indian - Alaska Native Health Cancer HPV Infection (Human Papillomavirus) MMWR Morbidity & Mortality Weekly Report Source Type: news

Britain's top surgeon admits 'we've never had to deal with anything like this' with NHS waiting list
Ben Challacombe, a consultant urological surgeon at Guy's and St Thomas', said a 'surge' of cancer cases will come in the wake of the pandemic. (Source: the Mail online | Health)
Source: the Mail online | Health - September 17, 2020 Category: Consumer Health News Source Type: news

Veliparib-Chemo Combo New Option for BRCA-Mutated Breast Cancer? Veliparib-Chemo Combo New Option for BRCA-Mutated Breast Cancer?
AbbVie reports that upfront veliparib maintains carboplatin-paclitaxel response, with manageable side effects.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - September 17, 2020 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Donald Trump Is Losing On An Issue Voters Care A Lot About. Here ’s How He’s Trying to Change That
With nearly 200,000 Americans dead from COVID-19 and millions more who lost their health insurance when they lost their jobs this year, President Donald Trump tried this week—as he has done throughout his presidency—to change the conversation. On Sunday, the President issued a new executive order aimed at lowering prescription drug prices, an issue dear to many voters, and boasted on Twitter that “prices are coming down FAST.” The reality is more complicated. Trump’s new executive order, which revokes and replaces a different executive order on drug prices that he signed in July, directs the...
Source: TIME: Health - September 17, 2020 Category: Consumer Health News Authors: Abigail Abrams Tags: Uncategorized 2020 Election COVID-19 Explainer News Source Type: news

Follow-up Confirms Apalutamide Survival Benefits in Some Men With Prostate Cancer Follow-up Confirms Apalutamide Survival Benefits in Some Men With Prostate Cancer
Apalutamide markedly extends overall survival in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC), according to a final analysis of data from the phase-3 SPARTAN study.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 17, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Accuray Radixact(R) System with Synchrony(R) Technology Delivers Advanced Cancer Treatments at Multiple Hospitals in Japan
First lung case in ASIA, and the first liver case in the world, were treated at Takarazuka City Hospital, Hyogo, Japan Japanese Red Cross Nagoya Daini Hospital, Aichi, and Kishiwada Tokushukai Hospital, Osaka, Japan, have started treating lung cases ... Devices, Oncology Accuray, Radixact System, Synchrony, radiosurgery (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 17, 2020 Category: Pharmaceuticals Source Type: news

Three-drug combo reduces risk for lung cancer by 17%, study finds
Taking aspirin, statins and the drug metformin together reduces the risk for lung cancer by 17%, a study published Thursday by the Journal of Thoracic Oncology found. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 17, 2020 Category: Consumer Health News Source Type: news

Novo Ventures co-leads US $83m series C financing in Lava Therapeutics
New investment to support advancement of powerful bispecific Gamma-Delta T cell engager programs for the treatment of a broad range of cancers Leading global life sciences venture has invested approx US$1 billion in last two years COPENHAGEN, Denmark... Biopharmaceuticals, Oncology, Venture Capital Novo Ventures, LAVA Therapeutics, gamma-delta T cells (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 17, 2020 Category: Pharmaceuticals Source Type: news

Coffee May Slow Spread of Colon Cancer
THURSDAY, Sept. 17, 2020 -- Just a few cups of coffee a day may help slow down the deadly progression of advanced colon cancer, new research finds. Of the nearly 1,200 patients in the study, those who drank four or more cups of java on a daily... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 17, 2020 Category: General Medicine Source Type: news

Cancer Incidence Up for Adolescents and Young Adults
THURSDAY, Sept. 17, 2020 -- Among adolescents and young adults (AYAs), cancer incidence increased during 2007 to 2016, according to a report published online Sept. 17 in CA: A Cancer Journal for Clinicians. Kimberly D. Miller, M.P.H., from the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 17, 2020 Category: Pharmaceuticals Source Type: news

Mother and Son Draw Hope, Healing From Shared Cancer Treatment
THURSDAY, Sept. 17, 2020 -- Families bond over lots of shared experiences -- but one Leslie Seigel and her adult son, Josh, never expected to share was battling cancer. Soon after Leslie finished chemotherapy for an aggressive form of breast... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 17, 2020 Category: General Medicine Source Type: news

A New Approach To A Deadly Breast Cancer Offers Hope To The Black Women It Affects Most
Dr. Karmella Haynes is tackling resistant triple-negative breast cancer through chromatin engineering. As this cancer type disproportionately affects Black women, Haynes seeks not only to advance chromatin science but to improve health outcomes for medically underserved patients. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - September 17, 2020 Category: Pharmaceuticals Authors: John Cumbers, Senior Contributor Tags: Manufacturing /manufacturing Business /business Innovation /innovation Healthcare /healthcare Source Type: news

The effects in the upper airway of heat and exposure to combustion byproducts of burning materials on larynx of firefighters - Korn GP, Alvarenga EHL, Dall'Oglio GP, Azevedo RR, Chamun W, Cordeiro TG, Boggi AC, Pezato R.
INTRODUCTION: High exposure to heat and combustion byproducts is associated with health problems and an increased risk of cancer. OBJECTIVE: To study the effects of heat and smoke derived from burning on the upper airway of firefighters. METHODS: T... (Source: SafetyLit)
Source: SafetyLit - September 17, 2020 Category: International Medicine & Public Health Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

PET shows promise for detecting NSCLC recurrence
F-18 FDG PET/CT shows promise for detecting recurrence of disease in non-small...Read more on AuntMinnie.comRelated Reading: PET radiomics tailor head/neck cancer treatment Nuclear medicine volume plummets due to COVID-19 Dual-phase technique improves PET/CT brain tumor imaging PET/CT could be useful for diagnosing fever PET/MRI ups lesion detection by 15% for some cancers (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2020 Category: Radiology Source Type: news

Women with DCIS have 3x the risk of breast cancer death
A new study adds weight to the belief that ductal carcinoma in situ (DCIS)...Read more on AuntMinnie.comRelated Reading: Delayed breast cancer surgery not tied to worse outcomes Preop MRI finds 11% more cancer in women with DCIS Years later, DCIS tied to more imaging but not anxiety Black women still at higher risk of breast cancer death Does imaging modality influence DCIS recurrence? (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 17, 2020 Category: Radiology Source Type: news

GAVRETO (pralsetinib), FDA Approved for Treatment of Metastatic RET Fusion-Positive Non-Small Cell Lung Cancer, Available at Biologics by McKesson
CARY, N.C., Sept. 17, 2020 —Biologics by McKesson, an independent specialty pharmacy specializing in oncology and rare disease areas, has been selected by Blueprint Medicines as a specialty pharmacy provider for GAVRETOTM (pralsetinib) for the treatment of adult patients with metastatic RET fusion-p... (Source: McKesson News)
Source: McKesson News - September 17, 2020 Category: Information Technology Source Type: news

Roche to present a broad range of data across multiple cancer types at the ESMO Virtual Congress 2020
Basel, 17 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that results from a number of studies across its broad oncology portfolio will be presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020, which will be held 19-21 September, 2020. Results include data from three phase III studies across the Tecentriq® (atezolizumab) triple-negative breast cancer (TNBC) programme. Central nervous system (CNS) efficacy data from integrated analyses of the pivotal phase II Rozlytrek® STARTRK-2, phase I STARTRK-1, and phase I ALKA-372-001 trials will be presented in addition to re...
Source: Roche Investor Update - September 17, 2020 Category: Pharmaceuticals Source Type: news

Roche to present a broad range of data across multiple cancer types at the ESMO Virtual Congress 2020
Basel, 17 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that results from a number of studies across its broad oncology portfolio will be presented at the European Society for Medical Oncology (ESMO) Virtual Congress 2020, which will be held 19-21 September, 2020. Results include data from three phase III studies across the Tecentriq® (atezolizumab) triple-negative breast cancer (TNBC) programme. Central nervous system (CNS) efficacy data from integrated analyses of the pivotal phase II Rozlytrek® STARTRK-2, phase I STARTRK-1, and phase I ALKA-372-001 trials will be presented in addition to re...
Source: Roche Media News - September 17, 2020 Category: Pharmaceuticals Source Type: news

Spotting breast cancer's spread to the brain before symptoms start could improve survival
(European Organisation for Research and Treatment of Cancer) Breast cancer patients whose disease has spread to their brains fare better if their metastases are picked up before they begin to cause symptoms, according to a study presented at the 12th European Breast Cancer Conference. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Pattern of gut bacteria linked to effectiveness of chemotherapy in breast cancer patients
(European Organisation for Research and Treatment of Cancer) Researchers studying the activity of gut bacteria in breast cancer patients have found a possible link with how well their chemotherapy works. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Access to cancer medicines and clinical trials show stark variations across Europe
(European Society for Medical Oncology) Access to cancer medicines is highly unequal across Europe both for new drugs in development because of uneven access to clinical trials and for currently approved drugs due to huge disparities in healthcare spending by different countries, according to results from studies presented at ESMO 2020. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

New study estimates nearly 90,000 cancer cases diagnosed in adolescents and young adults
(American Cancer Society) A new report examining cancer in adolescents and young adults (AYAs), defined as diagnoses occurring during ages 15 to 39, provides updated estimates of the contemporary cancer burden in this age group, predicting that 89,500 cases and 9,270 deaths will occur in 2020 in the United States. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Algorithms uncover cancers' hidden genetic losses and gains
(Princeton University, Engineering School) Limitations in DNA sequencing technology make it difficult to detect some major mutations often linked to cancer, such as the loss or duplication of parts of chromosomes. Now, methods developed by Princeton computer scientists will allow researchers to more accurately identify these mutations in cancerous tissue, yielding a clearer picture of the evolution and spread of tumors than was previously possible. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news

PET/MRI improves lesion detection, reduces radiation exposure
(Society of Nuclear Medicine and Molecular Imaging) A single-center observational study of more than 1,000 oncological examinations has demonstrated that positron emission tomography/magnetic resonance imaging (PET/MRI) facilitates cancer staging as well as PET/computed tomography (PET/CT) and improves lesion detectability in select cancers, potentially helping to promote fast, efficient local and whole-body staging in one step. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news

Morris Animal Foundation awards nearly $1M in grants for new studies for equine health
(Morris Animal Foundation) Morris Animal Foundation, a leader in advancing animal health, has awarded nearly $1 million in large animal health research grants, supporting 14 projects. The studies will help veterinary scientists improve the well-being of horses through improved prevention and treatment of numerous health challenges, including eye cancer, heart arrhythmias and risks for injury from air transport. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news

Three common medications lower risk and mortality for lung cancer
(International Association for the Study of Lung Cancer) Combined use of aspirin, statins, and metformin is associated with decreased lung cancerincidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Examining association of coffee consumption, survival in patients with colorectal cancer
(JAMA Network) Researchers in this observational study investigated the association between the number of cups of coffee consumed per day and survival in patients with advanced or metastatic colorectal cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Changes in lung cancer treatment during COVID-19 pandemic
(JAMA Network) Changes in   lung cancer treatment during the COVID-19 pandemic were evaluated in this study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Coffee associated with improved survival in metastatic colorectal cancer patients
(Dana-Farber Cancer Institute) In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers at Dana-Farber Cancer Institute and other organizations report in a new study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

The Mark Foundation launches Inaugural Industry Advisory Committee
(The Mark Foundation for Cancer Research) What's especially interesting here is that we developed a new playbook for the how foundations can play a transformational role in bridging the gap between great academic ideas and marketed products - getting past the " valley of death. " (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

New partnership to build advanced predictive testing for blood cancer multiple myeloma
(RCSI) By combining genomic testing and next generation sequencing technology, a new partnership led by RCSI researchers aims to advance predictive tests for multiple myeloma (MM), the second most common blood cancer in Ireland. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Kang finds keys to control the 'driver of cancer's aggressiveness'
(Princeton University) A dangerous protein named SNAI2 helps cancers metastasize and shields cancer from both the immune system and chemotherapy. Worse, SNAI2 is in a family of proteins that are notoriously hard to fight with drugs. But now Princeton University's Yibin Kang and his colleagues have found a way to use the cell's recycling system to control SNAI2, providing a new possibility for treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

NIH funds research into differences in glioblastoma between males and females
(Cleveland Clinic) A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females. The researchers will delve into the genetics, epigenetics and cell biology of glioblastoma - the most common and deadliest brain tumor in adults - to better understand the physiologic processes which may lead to more personalized therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

PPIs may affect responses to atezolizumab in patients with urothelial cancer
(American Association for Cancer Research) Proton pump inhibitor (PPI) use was associated with worse outcomes in patients with urothelial cancer treated with the immunotherapeutic atezolizumab (Tecentriq), compared with patients who did not use PPIs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
In this study, we isolated three bacterial species—Bifidobacterium pseudolongum, Lactobacillus johnsonii, and Olsenella species—that significantly enhanced efficacy of immune checkpoint inhibitors in four mouse models of cancer. We found that intestinal B. pseudolongum modulated enhanced immunotherapy response through production of the metabolite inosine. Decreased gut barrier function induced by immunotherapy increased systemic translocation of inosine and activated antitumor T cells. The effect of inosine was dependent on T cell expression of the adenosine A2A receptor and required costimulation. Collectively...
Source: ScienceNOW - September 17, 2020 Category: Science Authors: Mager, L. F., Burkhard, R., Pett, N., Cooke, N. C. A., Brown, K., Ramay, H., Paik, S., Stagg, J., Groves, R. A., Gallo, M., Lewis, I. A., Geuking, M. B., McCoy, K. D. Tags: Immunology, Medicine, Diseases reports Source Type: news