Interesting Epidemiological Results for Time Restricted Feeding
In this study, researchers investigated the potential long-term health impact of following an 8-hour time-restricted eating plan. They reviewed information about dietary patterns for participants in the annual 2003-2018 National Health and Nutrition Examination Surveys (NHANES) in comparison to data about people who died in the U.S., from 2003 through December 2019, from the Centers for Disease Control and Prevention's National Death Index database. The analysis found: (a) people who followed a pattern of eating all of their food across less than 8 hours per day had a 91% higher risk of death due to cardiovascular d...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Estrogen-Related Receptor Agonists as Exercise Mimetic Drugs
Just as the research community is interested in finding pharmaceutical ways to provoke some the beneficial reactions to calorie restriction, there is also considerable effort devoted to the search for drug candidates that can mimic some of the benefits of exercise. If the history of calorie restriction mimetic drug development is any guide, this will be a slow process, and the resulting compounds will produce lesser benefits than actual exercise, as they will only touch on a small subset of the processes involved. Still, there is no shortage of programs in this space, and here is one example. Exercise benefits bot...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology. « Back to Top Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ret-He: Reticulocyte hemoglobin equivalent – Marker for iron deficiency in ADHF
It is well known that iron deficiency is associated with poor outcome in acute decompensated heart failure. Different criteria like serum ferritin less than 100 ng/mL or 100-299 ng/mL with transferrin saturation less than 20% have been used to define iron deficiency. Inflammation which is common in heart failure may hinder serum ferritin values [1]. Another marker which has been proposed is reticulocyte hemoglobin equivalent (Ret-He) which is thought to reflect the iron content in reticulocytes. In a study of 225 patients with ADHF from Japan, median left ventricular ejection fraction was 37%. Median hemoglobin level was ...
Source: Cardiophile MD - March 22, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs

Transforming Clinical Quality & Value in Rehabilitation with Neurocognitive Technology
The following is a guest article by Jared Gillespie, Senior Director of Clinical Solutions at Academy Medtech Ventures (AMV) In the landscape of rehabilitative care, the integration of neurocognitive technology stands as a beacon of innovation, charting a course toward improved clinical quality and patient outcomes. This journey into the brain’s potential within rehabilitation not only elevates the standard of care but also underscores the role of advanced technologies in shaping the future of healthcare. Traditional rehabilitative care has predominantly focused on physical recovery, often overlooking the brain’...
Source: EMR and HIPAA - March 22, 2024 Category: Information Technology Authors: Guest Author Tags: Clinical Communication and Patient Experience Health IT Company Healthcare IT Hospital - Health System Academy Medtech Ventures AMV Clinical Quality Healthcare Transformation Jared Gillespie Neurocognitive Technology rehabilitative c Source Type: blogs

Aspects of Skin Aging Encourage Metastasis in Melanoma
There are many ways in which the aging of tissue makes cancer both more likely to occur and more aggressive once it does occur. Here researchers focus in on specific changes in aged skin tissue that make melanoma cancers more likely to become metastatic and spread to other organs. Interestingly, it is an indirect effect on cell signaling that is mediated by increased stiffness of the skin extracellular matrix, an issue in many aging tissues that has many root causes, not just the one noted here. Nonetheless, if metastasis could be shut down, then cancer would become a much more tractable problem, particularly if control of...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
This study provides some insight into how these relationships play out in practice by sabotaging telomerase and p53, and observing the results. Telomerase activity is restricted in humans and telomere attrition occurs in several tissues accompanying natural aging. Critically short telomeres trigger DNA damage responses and activate p53 which leads to apoptosis or replicative senescence. These processes reduce cell proliferation and disrupt tissue homeostasis, thus contributing to systemic aging. Similarly, zebrafish have restricted telomerase expression, and telomeres shorten to critical length during their lifesp...
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Inside the cancer waiting room where hope hangs in the balance
I sat there, frozen in time, full of fear, full of anxiety. Waiting for my time to “face the music,” but this wasn’t a dance party. My fellow patients, complete strangers, were seated about me, and each of us kept a safe distance apart from each other—a carry-over from the pandemic, I guess. All of Read more… Inside the cancer waiting room where hope hangs in the balance originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 17, 2024 Category: General Medicine Authors: Tags: Conditions Oncology/Hematology Source Type: blogs

Three Ways AI, If Trusted, Can Transform the Healthcare Landscape
The following is a guest article by Jeanne Greathouse, Healthcare Development Director, AI Regulatory Services at BSI 77% of Healthcare Workers Say They May Be Ready to Let AI Take on Administrative Work Few industries have been stress-tested as thoroughly as the healthcare system during COVID-19 when, at the worst moments, 22% of US hospitals were reporting staff shortages. Even three years on, the World Health Organization found that 84% of countries were still experiencing some disruption. Amid a period of tremendous medical uncertainty and service disruption, health workers and first responders functioned like a life v...
Source: EMR and HIPAA - March 15, 2024 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning C-Suite Leadership Health IT Company Healthcare IT Hospital - Health System Artificial Intelligence BSI Healthcare Efficiency Healthcare Transformation Improving Patient Care Jeanne Greathouse Medical Innovation Source Type: blogs

SOX17 Allows Early Stage Colon Cancer to Evade the Immune System
Researchers here report on work that identifies SOX17 inhibition as a potential way to attack colon cancer in its early stages. Any successful cancer must have adopted one or more ways to suppress the immune system in order to grow past the earliest stages of a few cancerous cells. Interfering in those suppression mechanisms is a potential basis for therapy, as the researchers demonstrated here. Whether or not this line of work will make much further depends on whether an economically viable approach to SOX17 inhibition can be found, and whether or not it is a good target for many other forms of cancer. Colon canc...
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Science Snippet: Examining Enzymes
Structure of a pyruvate kinase, an enzyme that adds a phosphate group to adenosine diphosphate (ADP) to make adenosine triphosphate (ATP). Credit: PDB 7UEH. Every day, our cells must produce all the various molecules they need to stay alive. But the chemical reactions to create these molecules can’t occur without help—which is where enzymes come in. Enzymes are biological catalysts, meaning they speed up the rate of specific chemical reactions by reducing the amount of energy needed for the reaction to occur. Most enzymes are proteins, but some RNA molecules can also act as enzymes. Thousands of different enzymes ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 13, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes Proteins Science Snippet Source Type: blogs

Optimism on the Timeline for Extending Human Lifespans by 20 Years or More
In the interview noted here, Aubrey de Grey of the Longevity Escape Velocity (LEV) Foundation makes a bold prediction of 12-15 years as to when we might see the advent of the first therapies capable of extending the healthy human life span by a few decades, allowing older people to live long enough to benefit from following improvements to further extend their healthy life spans. It is worth bearing in mind that the creation of novel therapies doesn't mean widespread use or even easy availability of those therapies. Further, it is unlikely that we'll know the effects on human life span of any given combination of novel rej...
Source: Fight Aging! - March 11, 2024 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Bonus Features – March 10, 2024 – Only 36% of CEOs have assessed how to govern the risks of AI, Emory Healthcare is deploying Epic on MacBook Air, plus 27 more stories
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News The Biden Cancer Moonshot is advancing a recommended minimum set of key cancer-related data elements under USCDI+ Cancer, a subset of United States Core Data for Interoperability. Atlanta’s Emory Healthcare is deploy...
Source: EMR and HIPAA - March 10, 2024 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Alayacare Amwell Apple Vision Pro Cancer Moonshot CCS CHG Healthcare ClearDATA Dr. Geeta Nayyar Emory Healthcare Epic Hyperspace Ernst & Young eXeX Experis FDB FertilAI Google Cloud Healthcare IT Today Bonus Source Type: blogs