Antitumor necrosis factor- α antibodies as a noveltherapy for hepatocellular carcinoma.
Antitumor necrosis factor-α antibodies as a noveltherapy for hepatocellular carcinoma. Exp Ther Med. 2018 Aug;16(2):529-536 Authors: Li W, Jian YB Abstract Hepatocellular carcinoma (HCC) accounts for many cases of cancer-associated mortality. Tumor necrosis factor (TNF)-α is a key mediator of tumor-promoting inflammation. It has been demonstrated that anti-TNF-α treatments have preclinical benefits for multiple types of cancer, however their potential for treating HCC remains unclear. Through fluorescence-activated cell sorter analysis and enzyme-linked immunosorbent assay, the result...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Anti-neuropilin-1 monoclonal antibody suppresses the migration and invasion of human gastric cancer cells via Akt dephosphorylation.
Authors: Ding Y, Zhou J, Wang S, Li Y, Mi Y, Gao S, Xu Y, Chen Y, Yan J Abstract Neuropilin-1 (NRP-1) is involved in a range of physiological and pathological processes, including neuronal cell guidance, cardiovascular development, immunity, angiogenesis and the pathogenesis of cancer. Targeting of NRP-1 is considered to be a potential cancer therapy and a number of approaches have been investigated, including the use of small interfering RNA, peptides, soluble NRP antagonists and monoclonal antibodies. The present study used a novel anti-neuropilin-1 monoclonal antibody (anti-NRP-1 mAb) to investigate its potentia...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

TTB2 induces apoptosis in Ewing sarcoma cells.
Authors: Zou X, Huang W Abstract A steroidal saponin named pennogenin 3-O-α-L-rhamnopyranosyl-(1→2) [α-L-rhamnopyranosyl-(1→4)]-β-D-glucoyranoside(TTB2) has been successfully separated from the n-BuOH extracts of Trillium tschonoskii Maxim and is able to induce cytotoxicity to some types cancer cells. The present study aimed to investigate how this novel saponinin duces cytotoxicity in malignant sarcoma cells and to clarify its molecular mechanisms of action. It was determined this steroidal saponin induced the apoptosis in Rh1 cells and activated caspase-3 and caspase-9. Additionally, it...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-302 inhibits cell migration and invasion in cervical cancer by targeting DCUN1D1.
Authors: Jiang Y, Hou R, Li S, Li S, Dang G Abstract MicroRNA serve crucial roles in a variety of human cancer types. The miR-302-367 cluster has been reported to suppress the proliferation of cervical carcinoma cells through the novel target AKT1; however, the molecular mechanism of miR-302 in cervical cancer metastasis remains unclear. The present study aimed to investigate the clinical significance of miR-302-3p expression in cervical cancer, and to examine the regulatory mechanism of miR-302-3p in the malignant phenotypes of cervical cancer cells. The present data indicated that miR-302-3p was significantly dow...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Natural killer cells inhibit metastasis of ovarian carcinoma cells and show therapeutic effects in a murine model of ovarian cancer.
In conclusion, the present study suggested that NK cell immunotherapy inhibited systemic metastasis of ovarian cancer cells and improved the survival rate of mice. Sufficient supplementation of NK cells may serve as a promising immunotherapeutic strategy for ovarian cancer. PMID: 30116358 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Antitumor effects of carbon nanotube-drug complex against human breast cancer cells.
Authors: Yu S, Zhang Y, Chen L, Li Q, Du J, Gao Y, Zhang L, Yang Y Abstract To improve the bio-solubility and sustained-release properties of a carbon nanotube (CNT)-drug complex, the present study used a hydrophilic polymer, polyethylene glycol (PEG), and β-estradiol (E2), which targets the estrogen receptor in human breast cancer cells (HBCCs), to modify CNTs carrying lobaplatin (LBP) to form E2-PEG-CNT-LBP. The in vitro inhibitory effects against HBCCs and the in vivo pharmacological effect of the complex on heart, liver and kidney tissues were also evaluated. The results indicated that the inhibitory effec...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effects of CoCl2-simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells.
Authors: Zhang X, Chen L Abstract Renal cell carcinoma (RCC) and chronic kidney disease (CKD) are associated with hypoxia, but the effects of hypoxia on the process of angiogenesis in the two diseases are dramatically different. Some of matrix metalloproteinases (MMPs), such as MMP2 and MMP9, may have a role because they represent the most prominent family of proteinases associated with angiogenesis. In the present study, the differential response of human renal cell cancer cells (786-0), human renal tubular epithelial cells (HK-2) and human microvascular endothelial cells (HMEC-1) to hypoxia with regards to the ex...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Insulin-like growth factor 1/insulin-like growth factor 1 receptor signaling protects against cell apoptosis through the PI3K/AKT pathway in glioblastoma cells.
Authors: Zhang M, Liu J, Li M, Zhang S, Lu Y, Liang Y, Zhao K, Li Y Abstract Glioblastoma multiforme (GBM) is a malignant tumor caused by complex pathological mechanisms, and is characterized by a high rate of cancer-related mortality and poor patient prognosis. Overgrowth of cancer cells, which results from the inhibition of cell apoptosis and/or the promotion of cell proliferation, leads to the progression of GBM. Therefore, studies into the regulatory mechanisms of cancer cell growth in GBM are required to identify potential therapeutic targets and improve treatment for GBM. In the present study, the role of ins...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Paeoniflorin inhibits IL-1 β-induced MMP secretion via the NF-κB pathway in chondrocytes.
Paeoniflorin inhibits IL-1β-induced MMP secretion via the NF-κB pathway in chondrocytes. Exp Ther Med. 2018 Aug;16(2):1513-1519 Authors: Hu PF, Sun FF, Jiang LF, Bao JP, Wu LD Abstract Paeoniflorin serves important cellular roles, exerting anti-cancer, anti-inflammatory and anti-pulmonary fibrosis effects and possesses immune-modulatory properties. However, the exact role of paeoniflorin in the pathogenesis of osteoarthritis (OA) remains unclear. The aim of the present study was to investigate the effects of paeoniflorin on articular surfaces in vitro. Rat chondrocytes were cultured in vitro...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Personalized genomic analysis based on circulating tumor cells of extra-skeletal Ewing sarcoma of the uterus: A case report of a 16-year-old Korean female.
Authors: Lee SY, Lim S, Cho DH Abstract A 16-year-old female with Ewing sarcoma, a very rare disease with poor prognosis in women, was admitted to the hospital with abdominal pain. Diagnostic laparotomy revealed the Ewing sarcoma originating from the extramural uterus. Histological examination yielded positive test results for CD99, vimentin, S-100, eosin 5-maleimide and periodic acid-Shiff. EWS-FLI1 type 1 translocation was confirmed. Fibroblast growth factor receptor (FGFR) 4 (c.1162G> A) and HRas proto-oncogene (HRAS; c.182A> G) mutations were also detected. At eight months following complete remission, pe...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells.
In conclusion, curcumin inhibited the proliferation of breast cancer cells and induced G2/M phase cell cycle arrest and apoptosis, which may be associated with the decrease of CDC25 and CDC2 and increase of P21 protein levels, as well as inhibition of the phosphorylation of Akt/mTOR and induction of the mitochondrial apoptotic pathway. The findings of the present study may provide a basis for the further study of curcumin in the treatment of breast cancer. PMID: 30116377 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death.
Authors: Chira S, Raduly L, Braicu C, Jurj A, Cojocneanu-Petric R, Pop L, Pileczki V, Ionescu C, Berindan-Neagoe I Abstract Cancer, and particularly colon cancer, is associated with an increasing number of cases resistant to chemotherapy. One approach to overcome this, and to improve the prognosis and outcome of patients, is the use of adjuvant therapy alongside the standard chemotherapy regiment. In the present study, the effect of deuterium-depleted water (DDW) as a potential modulator of adjuvant therapy on DLD-1 colorectal cancer models was assessed. A number of functionality assays were performed, including MT...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-423-5p inhibits colon cancer growth by promoting caspase-dependent apoptosis.
Authors: Jia W, Yu T, An Q, Cao X, Pan H Abstract Plasma microRNA (miR)-423-5p is a potential biomarker for the detection of colon cancer. However, the expression and biological role of miR-423-5p in colon tumorigenesis remains unclear. In the current study, reverse transcription-quantitative polymerase chain reaction was used to determine miR-423-5p expression in malignant colon tissues and plasma from patients with colon cancer. Cell viability, colony formation and apoptosis assays, as well as western blotting, were performed to investigate the biological role and regulatory mechanisms of miR-423-5p in colon canc...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effect of lanthanum chloride on tumor growth and apoptosis in human ovarian cancer cells and xenograft animal models.
Authors: Wang F, Zhu Y, Fang S, Li S, Liu S Abstract Ovarian cancer is the leading cause of mortality resulting from gynecologic cancer. A common anti-ovarian tumor drug is cisplatin; however, repeated use of cisplatin causes severe resistance and leads to poor long-term survival rate in ovarian cancer patients. Recently, it was reported that lanthanum chloride (LaCl3) may inhibit tumor growth and induce apoptosis in certain cancer cells. In the present study, the effect of LaCl3 on ovarian cancer was determined in vivo and in vitro. A cisplatin-sensitive human ovarian cancer cell line, COC1, was used in the curren...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

miR-6852 serves as a prognostic biomarker in colorectal cancer and inhibits tumor growth and metastasis by targeting TCF7.
In this study, it was demonstrated that miR-6852 was underexpressed in CRC tissues compared with adjacent normal tissues. Moreover, the expression of miR-6852 was negatively correlated with CRC metastasis, whereas positively correlated with patient prognosis. It was revealed that the overexpression of miR-6852 significantly inhibited the proliferation and invasion of CRC cells. miR-6852 overexpression reduced CRC cells in the S phase. TCF7 was identified to be a direct target of miR-6852 in CRC cells. Overexpression of miR-6852 significantly inhibited the mRNA and protein levels of TCF7 in CRC cells. Furthermore, TCF7 was ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Triptolide inhibits vascular endothelial growth factor-mediated angiogenesis in human breast cancer cells.
Authors: Liu H, Tang L, Li X, Li H Abstract Triptolide has been demonstrated to induce tumor cell apoptosis. However, the role of triptolide in breast cancer angiogenesis remains unclear. The present study aimed to investigate the function of triptolide in breast cancer and the molecular mechanisms underlying this. The results revealed that triptolide could significantly decrease the expression of vascular endothelial growth factor A (VEGFA) in Hs578T and MDAMB231 breast cancer cells. Furthermore, human umbilical vein endothelial cells were used to perform tube formation and bromodeoxyuridine incorporation assays, ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma.
Authors: Ou X, Guan J, Chen JS, Ying JC, Liu XP, Tian PK, Liu JK, Nie LP, Zhao Y, Yu GY Abstract The purpose of the present study was to investigate the role of latency-associated peptide (LAP)+CD4+T cells in hepatocellular carcinoma (HCC) immunity. Flow cytometric analysis was performed to detect the proportion of LAP+CD4+ T cells among the peripheral blood mononuclear cells (PBMCs) of 30 HBV-infected HCC patients at the pre-operative and post-operative stages, as well as 30 hepatitis B virus (HBV)-infected volunteers as a control group. Furthermore, tumor tissues and peri-tumor tissues from 28 patients with HCC, ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Leptin promotes the growth of breast cancer by upregulating the Wnt/ β-catenin pathway.
Leptin promotes the growth of breast cancer by upregulating the Wnt/β-catenin pathway. Exp Ther Med. 2018 Aug;16(2):767-771 Authors: Liang X, Wang S, Wang X, Zhang L, Zhao H, Zhang L Abstract The present study aimed to investigate the role of leptin in the growth of breast cancer. In the present study, expression of leptin in tumor tissues and adjacent tissues was detected by reverse transcription-quantitative polymerase chain reaction. Serum leptin in patients with breast cancer and normal healthy controls was detected by ELISA. Different concentrations of leptin were used to treat breast cancer ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Targeting cysteine-rich angiogenic inducer-61 by antibody immunotherapy suppresses growth and migration of non-small cell lung cancer.
Authors: Li X, Yuan N, Lin L, Yin L, Qu Y Abstract Non-small cell lung cancer (NSCLC) is the most frequent type of human lung cancer; lung cancer is responsible for the highest rates of cancer-associated mortality in the world. Cysteine-rich angiogenic inducer-61 (CYR-61) has been identified as a tumorigenesis-, development- and metastasis-related gene, and is reported to enhance proliferation, migration and invasion through hepatocyte growth factor (HGF)-induced scattering and the metastasis-inducing HGF/Met signaling pathway in tumor cells and xenograft models. CYR-61 is a protein that promotes human lung cancer ...
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Attitudes and Experiences of Men with Prostate Cancer on Risk in the Context of Injuries Related to Community-based Football - A Qualitative Study.
Authors: Rørth M, Tjørnhøj-Thomsen T, Cormie P, Oliffe JL, Midtgaard J Abstract While football training may be a potent strategy for health promotion in older men, the considerable risk of injuries may constitute a barrier for referral of clinical populations. The current study explored the attitudes of men with prostate cancer on risk in the context of injuries related to participating in a community-based football program. Four videotaped focus group interviews, and three individual in-depth telephone interviews were carried out with men with prostate cancer (n=35; mean age 68.8). Thematic ne...
Source: Journal of Aging and Physical Activity - August 19, 2018 Category: Geriatrics Tags: J Aging Phys Act Source Type: research

Significance of Preoperative Systemic Immune Score for Stage I Gastric Cancer Patients.
Conclusions: Patients with SIS = 2 may benefit from AC and thus may be considered candidates for adjuvant treatment. However, to confirm our findings, future prospective studies are warranted. PMID: 30116261 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - August 19, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Analysis of Prognostic Factors for Resected Synchronous and Metachronous Liver Metastases from Colorectal Cancer.
Authors: Bartolini I, Ringressi MN, Melli F, Risaliti M, Brugia M, Mini E, Batignani G, Bechi P, Boni L, Taddei A Abstract Background: Surgical treatment is the cornerstone in the management of colorectal cancer (CRC) liver metastases. The aim of this study is to identify clinicopathological factors affecting disease-free (DFS) and overall survival (OS) in patients undergoing potentially curative liver resection for CRC metastasis. Methods: All consecutive patients undergoing liver resection for first recurrence of CRC from February 2006 to February 2018 were included. Prognostic impact of factors related to th...
Source: Gastroenterology Research and Practice - August 19, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Label-free FTIR spectroscopy detects and visualizes the early stage of pulmonary micrometastasis seeded from breast carcinoma
Publication date: Available online 18 August 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Karolina Chrabaszcz, Agnieszka Jasztal, Marta Smęda, Bartosz Zieliński, Aneta Blat, Max Diem, Stefan Chlopicki, Kamilla Malek, Katarzyna M. MarzecAbstractAn application of FTIR spectroscopic imaging for the identification and visualization of early micrometastasis from breast cancer to lungs in a murine model is shown. Spectroscopic and histological examination is focused on lung cross-sections derived from animals at the early phase of metastasis (early micrometastasis, EM) as compared to h...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - August 19, 2018 Category: Molecular Biology Source Type: research

Ectopic expression of OX1R in ulcerative colitis mediates anti-inflammatory effect of orexin-A
Publication date: Available online 18 August 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): N. Messal, N. Fernandez, S. Dayot, V. Gratio, P. Nicole, C. Prochasson, I. Chantret, G. LeGuilloux, A. Jarry, A. Couvelard, X. Tréton, T. Voisin, E. Ogier-Denis, A. CouvineauAbstractOrexins (orexin-A and orexin-B) are hypothalamic peptides that are produced by the same precursor and are involved in sleep/wake control, which is mediated by two G protein-coupled receptor subtypes, OX1R and OX2R. Ulcerative colitis (UC) is an inflammatory bowel disease, (IBD) which is characterized by long...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - August 19, 2018 Category: Molecular Biology Source Type: research

Probing the antigen-antibody interaction towards ultrasensitive recognition of cancer biomarker in adenocarcinoma cell lysates using layer-by-layer assembled silver nano-cubics with porous structure on cysteamine caped GQDs
Publication date: Available online 18 August 2018Source: Microchemical JournalAuthor(s): Mohammad Hasanzadeh, Samira Rahimi, Elham Solhi, Ahad Mokhtarzadeh, Nasrin Shadjou, Jafar Soleymani, Soltanali MahboobAbstractThe incidence of breast cancer has been increasing over the years. To control and monitor this disease several tumor biomarkers have been proposed for early diagnosis, patient follow-up and/or treatment guidance. The only serum breast cancer biomarker in current use is the cancer antigen 15-3 (CA 15-3). Highly sensitive and label-free detection of the biomarker carbohydrate antigen 15-3 (CA 15-3) remains a chall...
Source: Microchemical Journal - August 19, 2018 Category: Chemistry Source Type: research

MR Imaging of Rectal Cancer.
This article aims to review current concepts in the management of patients with rectal cancer, including the most common surgical techniques, anatomic landmarks with MR imaging correlation, and the role of each imaging modality in local staging, focusing on MR imaging technique and its importance in primary staging, restaging, and local recurrence. PMID: 30119772 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - August 19, 2018 Category: Radiology Authors: Horvat N, Petkovska I, Gollub MJ Tags: Radiol Clin North Am Source Type: research

Current Status of Magnetic Resonance Colonography for Screening and Diagnosis of Colorectal Cancer.
This article provides an overview on the status and potential of magnetic resonance colonography in the setting of detection and screening of colorectal cancer and its precursors. PMID: 30119771 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - August 19, 2018 Category: Radiology Authors: van der Paardt MP, Stoker J Tags: Radiol Clin North Am Source Type: research

Low-Dose Computed Tomography Colonography Technique.
This article will discuss various strategies that may be utilized to reduce radiation dose and mitigate any increase in image noise that may occur. PMID: 30119769 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - August 19, 2018 Category: Radiology Authors: Chang KJ, Yee J Tags: Radiol Clin North Am Source Type: research

Low Vitamin D Deficiency Associated With Thyroid Disease Among Type 2 Diabetic Mellitus Patients.
Abstract Background: The aim of this study was to investigate the relationship between vitamin D deficiency and thyroid diseases among type 2 diabetes mellitus (T2DM) patients. Methods: This was a cohort case and control study, 546 T2DM patients and 546 control study participants were enrolled, aged between 25 and 65 years. The subjects were also investigated for fasting blood glucose levels (FBG), post prandial glucose (PPG,) glycosylated hemoglobin (HbA1c), thyroid stimulating hormone (TSH), T3, T4, and presence of other comorbid conditions. Thyroid fine needle aspiration biopsy was suggested to patients wh...
Source: Clin Med Res - August 19, 2018 Category: Research Authors: Bener A, Ozdenkaya Y, Al-Hamaq AOAA, Barisik CC, Ozturk M Tags: J Clin Med Res Source Type: research

Attachment Orientation and Relationships With Physicians and Nurses Among Israeli Patients With Advanced Cancer.
Abstract OBJECTIVES: To examine the association between attachment orientation and relationships with physicians and nurses among Israeli patients with advanced cancer. SAMPLE & SETTING: 52 patients with advanced cancer during active oncologic treatment. METHODS & VARIABLES: Eligible patients who agreed to participate in the study completed the Experience in Close Relationships Scale, Working Alliance Inventory-Short Revised, and a list of topics, which were defined by the research team as central and common to patients' coping. RESULTS: A correlation was found between avoidant attac...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Bar-Sela G, Gruber R, Mitnik I, Lulav-Grinwald D, Koren D Tags: Oncol Nurs Forum Source Type: research

Symptoms, Mobility and Function, and Quality of Life in Adults With Acute Leukemia During Initial Hospitalization.
Abstract OBJECTIVES: To examine longitudinal symptoms, mobility and function, and quality of life (QOL) in adults newly diagnosed with acute leukemia. SAMPLE & SETTING: 55 adults undergoing induction chemotherapy at the University of North Carolina Lineberger Comprehensive Cancer Center and the Duke Cancer Institute. METHODS & VARIABLES: A prospective, longitudinal study with measures of mobility and function, global physical and mental health, cancer-related fatigue, anxiety, depression, sleep disturbance, pain intensity, and leukemia-specific QOL was conducted. Data were analyzed using ...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Leak Bryant A, Coffman EM, Phillips B, Gray TF, Knafl GJ, Klepin HD, Wood WA, Muss H, Reeve BB Tags: Oncol Nurs Forum Source Type: research

Well-Being of Child and Family Participants in Phase 1 Pediatric Oncology Clinical Trials.
Abstract PROBLEM IDENTIFICATION: Pediatric oncology phase 1 clinical trials (P1Ts) are essential to developing new anticancer therapies; however, they raise complex ethical concerns about balancing the need for this research with the well-being of participating children. The purpose of this integrative review was to synthesize and appraise the evidence of how P1T participation, which begins with consent and ends with the transition off the P1T, can affect the well-being (either positively or negatively) of children with cancer. The Resilience in Individuals and Families Affected by Cancer Framework, which has an o...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Crane S, Haase JE, Hickman SE Tags: Oncol Nurs Forum Source Type: research

Food Safety Knowledge and Self-Reported Food-Handling Practices in Cancer Treatment.
Abstract OBJECTIVES: To explore awareness of foodborne infection risk during chemotherapy treatment, to assess knowledge of risk-reducing food safety practices in patients with cancer and their family caregivers, and to determine self-reported food-handling practices. SAMPLE & SETTING: A convenience sample of 121 patients receiving chemotherapy and 51 family caregivers of patients receiving chemotherapy in the United Kingdom recruited in the community and using online advertising. METHODS & VARIABLES: Participants completed a self-report questionnaire to determine food safety knowledge an...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Evans EW, Redmond EC Tags: Oncol Nurs Forum Source Type: research

Nurse-Delivered Symptom Assessment for Individuals With Advanced Lung Cancer.
Abstract OBJECTIVES: To assess an intervention derived from self-regulation theory (SRT) to promote well-being for individuals with advanced lung cancer. SAMPLE & SETTING: 45 adults with advanced lung cancer who were receiving chemotherapy at an ambulatory cancer center. METHODS & VARIABLES: Participants were randomized to the intervention group or usual care control group. Feasibility assessment focused on recruitment, retention, design, methods, and fidelity. Outcome measures of quality of life, symptoms, and distress were collected at four time points. The main research variables were ...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Flannery M, Stein KF, Dougherty DW, Mohile S, Guido J, Wells N Tags: Oncol Nurs Forum Source Type: research

Feelings of Disenfranchisement and Support Needs Among Patients With Thyroid Cancer.
Abstract PURPOSE: To offer a better understanding of the experiences, preferences, and needs of patients with thyroid cancer. PARTICIPANTS & SETTING: 17 patients with thyroid cancer receiving treatment at a university-affiliated hospital in Montreal, Québec, Canada. METHODOLOGIC APPROACH: Interviews were conducted with patients, and descriptive phenomenology was used to explore patients' lived experience. FINDINGS: Coping with uncertainty was a major theme that emerged from interviews, with some of the main concerns being difficult treatment decisions, long surgery wait times, and fea...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Henry M, Chang Y, Frenkiel S, Chartier G, Payne R, MacDonald C, Loiselle C, Black MJ, Mlynarek AM, Ehrler A, Rosberger Z, Tamilia M, Hier MP Tags: Oncol Nurs Forum Source Type: research

Response to "Taking Photos of Presentations: Dissemination or Distraction?"
Response to "Taking Photos of Presentations: Dissemination or Distraction?" Oncol Nurs Forum. 2018 Sep 01;45(5):565-566 Authors: Mahon SM Abstract I would like to thank Anne Katz, PhD, RN, FAAN, for her thoughtful editorial in the July 2018 issue of Oncology Nursing Forum. At least twice, that I am aware of, someone has used my slides without my permission. The first time happened about 10 years ago. I gave an educational program on the fundamentals of hereditary cancer syndromes at a regional conference for oncology nurses. I provided a detailed outline for note-taking and a list of referen...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Mahon SM Tags: Oncol Nurs Forum Source Type: research

Impact of Oral Anticancer Medication From a Family Caregiver Perspective.
Abstract PURPOSE: To describe how family caregivers of patients receiving oral anticancer medication (OAM) may affect family caregivers' lives and determine what support caregivers need to manage OAM in the home successfully. PARTICIPANTS & SETTING: Family caregivers of individuals with cancer prescribed OAM recruited from oncology clinics in the Midwest region of the United States. METHODOLOGIC APPROACH: Focus group methodology was used to elicit caregivers' perspectives. Sessions were audio recorded and transcribed verbatim. Qualitative analysis used a constant comparative approach. FINDIN...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Marshall VK, Vachon EA, Given BA, Lehto RH Tags: Oncol Nurs Forum Source Type: research

Feasibility of a Telemedicine-Delivered Cognitive Behavioral Therapy for Insomnia in Rural Breast Cancer Survivors.
Abstract OBJECTIVES: To evaluate a nurse-led, telemedicine-delivered cognitive behavioral therapy for insomnia (CBTI) in rural breast cancer survivors (BCSs). SAMPLE & SETTING: 18 BCSs diagnosed with stage I-III breast cancer in the rural western United States. METHODS & VARIABLES: In this prospective, pre-/post-test, quasiexperimental feasibility pilot trial, BCSs attended six weekly sessions of CBTI via Internet videoconference. Feasibility was assessed using recruitment and acceptability of the intervention. Primary outcomes were diary-based sleep efficiency (SE), sleep latency (SL), t...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: McCarthy MS, Matthews EE, Battaglia C, Meek PM Tags: Oncol Nurs Forum Source Type: research

Support Needs of People With Head and Neck Cancer Regarding the Disease and Its Treatment.
Abstract OBJECTIVES: To provide insight into people's experiences in dealing with the consequences of head and neck cancer (HNC) in daily life and their needs for self-management support. SAMPLE & SETTING: 13 people with HNC who were successfully treated in the Department of Radiation Oncology at the Erasmus MC Cancer Institute in Rotterdam, the Netherlands. METHODS & VARIABLES: Two focus groups and six individual interviews; data were analyzed with directed content analysis. RESULTS: Most patients wished to receive professional support for dealing with post-treatment consequences. A...
Source: Oncology Nursing Forum - August 19, 2018 Category: Nursing Authors: Peeters MAC, Braat C, Been-Dahmen JMJ, Verduijn GM, Oldenmenger WH, van Staa A Tags: Oncol Nurs Forum Source Type: research

Increased Expression of CD81 in Breast Cancer Tissue is Associated with Reduced Patient Prognosis and Increased Cell Migration and Proliferation in MDA-MB-231 and MDA-MB-435S Human Breast Cancer Cell Lines In Vitro.
Authors: Zhang N, Zuo L, Zheng H, Li G, Hu X Abstract BACKGROUND CD81, a member of the tetraspanin family, is overexpressed in several tumor types, but its role in breast cancer remains unknown. The present study aimed to investigate the effects of increased CD81 expression on cell migration and proliferation in breast cancer cell lines, MDA-MB-231 and MDA-MB-435S in vitro, and the effects of increased CD81 expression in breast cancer tissue microarrays on patient prognosis. MATERIAL AND METHODS The expression of CD81 was evaluated using immunohistochemistry in a human breast cancer tissue microarray containing 140...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Integrative Bioinformatics Analysis Reveals Potential Long Non-Coding RNA Biomarkers and Analysis of Function in Non-Smoking Females with Lung Cancer.
Authors: Qiao F, Li N, Li W Abstract BACKGROUND Lung cancer is the most lethal cancer worldwide. The aim of this study was to identify the tumor-related lncRNAs and explore their functions in female non-smokers with lung cancer. MATERIAL AND METHODS The gene expression microarray datasets GSE19804, GSE31210, and GSE31548 were downloaded from the Gene Expression Omnibus database. The differentially-expressed lncRNAs between non-smoking female lung cancer samples and non-tumor lung tissues were identified using GEO2R. RESULTS In total, 25, 40, and 15 differentially-expressed lncRNAs were obtained from GSE19804, GSE31...
Source: Medical Science Monitor - August 19, 2018 Category: Research Tags: Med Sci Monit Source Type: research

International testicular cancer incidence rates in children, adolescents and young adults
ConclusionThese differences in incidence rate variations in pediatric and AYA testicular cancer are intriguing and may aid in understanding the different etiologies of testicular cancer by age group. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - August 19, 2018 Category: Cancer & Oncology Source Type: research

Defining low-value PSA testing in a large retrospective cohort: Finding common ground between discordant guidelines
Publication date: October 2018Source: Cancer Epidemiology, Volume 56Author(s): Brock O’Neil, Christopher Martin, Ashley Kapron, Michael Flynn, Kensaku Kawamoto, Kathleen A. CooneyAbstractBackgroundReports of low-value prostate-specific antigen (PSA) testing (testing in which the harms outweigh the benefits) generally employ population level data sources. While such results may be generalizable, they often lack the detail necessary to understand provider clinical decision making and guideline concordance. Using a retrospective study of PSA testing at our institution we intend to characterize the frequency and patterns...
Source: Cancer Epidemiology - August 19, 2018 Category: Cancer & Oncology Source Type: research

[Search for the T790M mutation: The need to persevere].
We report 7 cases in which the identification of the T790M mutation required repeated analyses of cell free DNA and/or biopsies over a period of time. In some cases, a positive result was obtained a long time after progressive disease had been diagnosed during treatment with first or second generation EGFR-TKI. We discuss here the different modalities of screening for the T790M mutation and we encourage persevering in this search when no alternative mechanism of resistance has been identified. PMID: 30115389 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - August 19, 2018 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Update on small bowel surveillance in hereditary colorectal cancer syndromes.
Authors: Sanchez-Mete L, Stigliano V Abstract Despite its rarity in the general population, small bowel adenocarcinoma risk is increased in individuals with hereditary colorectal cancer syndromes (HCCS). In the last decade, the advent of capsule endoscopy and device-assisted balloon enteroscopy procedures in patients with HCCS have allowed to investigate the whole small bowel, increasing the diagnostic yield of small bowel tumor. Nonetheless, there is a significant variability in the international guideline recommendations. The aim of this review is to provide an update on surveillance of small bowel in HCCS and to...
Source: Tumori - August 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

"What shall I do when I grow up?" Adolescents with cancer on the Youth Project in Milan play with their imagination and photography.
CONCLUSION: By writing about their dreams, these patients gave their doctors a glimpse of their inner world. The project proved an important complement to more conventional forms of psychosocial support and interaction with young patients. PMID: 30117377 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Performance of tumor testing for Lynch syndrome identification in patients with colorectal cancer: A retrospective single-center study.
CONCLUSIONS: This study confirms the effectiveness of tumor testing to identify LS among patients with CRC. Although IHC and MSI analysis were similarly effective, IHC could be a better strategy for LS identification as it is less expensive and more feasible. PMID: 30117378 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in rectal cancer patients following neoadjuvant chemoradiotherapy.
Authors: Kim TG, Park W, Kim H, Choi DH, Park HC, Kim SH, Cho YB, Yun SH, Kim HC, Lee WY, Lee J, Kang KM Abstract PURPOSE: There is uncertainty over the effect of systemic inflammatory response on oncologic outcomes in patients who underwent neoadjuvant chemoradiotherapy and surgery for rectal cancer. We investigated the association between neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) as markers of systemic inflammation and tumor response and prognosis after treatment. METHODS: A total of 176 patients who underwent neoadjuvant chemoradiotherapy and curative surgery for rectal cancer wer...
Source: Tumori - August 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Cancer precision medicine today: Towards omic information in healthcare systems.
CONCLUSIONS: The proposed architecture could improve the potentialities of data routinely collected in many health information systems to form a real patient center information environment. PMID: 30117369 [PubMed - as supplied by publisher] (Source: Tumori)
Source: Tumori - August 19, 2018 Category: Cancer & Oncology Tags: Tumori Source Type: research

Synthesis of temperature/pH dual-sensitive supramolecular micelles from β-cyclodextrin-poly(N-isopropylacrylamide) star polymer for drug delivery
Publication date: Available online 18 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Zaishuai Zhou, Guiying Li, Nairong Wang, Feng Guo, Lei Guo, Xunyong LiuAbstractIn this paper, temperature and pH dual-sensitive supramolecular micelles were constructed from star polymer β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) and benzimidazole terminated poly(ε-caprolactone) (BM-PCL). The supramolecular micelles were formed based on the reversible host-guest recognition between β-CD and BM. The size of supramolecular micelles was about 50–100 nm and the LCST was abo...
Source: Colloids and Surfaces B: Biointerfaces - August 19, 2018 Category: Biochemistry Source Type: research