A zwitterionic salt –cocrystal: in vitro insights from niraparib tosylate, an anti-cancer drug
CrystEngComm, 2024, Advance Article DOI: 10.1039/D4CE00114A, PaperRamesh Reddy Mudda, Ramesh Devarapalli, Arijit Das, Pulla Reddy Lakkireddy, C. Malla Reddy, Ramanaiah Chennuru Schematic representation showing nomenclature of different cocrystals. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - March 28, 2024 Category: Chemistry Authors: Ramesh Reddy Mudda Source Type: research

Amplifying Immune Responses: Microparticulate Vaccine Approach Against Breast Cancer
(Source: Vascular Health and Risk Management)
Source: Vascular Health and Risk Management - March 28, 2024 Category: Cardiology Tags: Breast Cancer: Targets and Therapy Source Type: research

Second-Order Effects of Chemotherapy Pharmacodynamics and Pharmacokinetics on Tumor Regression and Cachexia
Bull Math Biol. 2024 Mar 28;86(5):47. doi: 10.1007/s11538-024-01278-0.ABSTRACTDrug dose response curves are ubiquitous in cancer biology, but these curves are often used to measure differential response in first-order effects: the effectiveness of increasing the cumulative dose delivered. In contrast, second-order effects (the variance of drug dose) are often ignored. Knowledge of second-order effects may improve the design of chemotherapy scheduling protocols, leading to improvements in tumor response without changing the total dose delivered. By considering treatment schedules with identical cumulative dose delivered, we...
Source: Bulletin of Mathematical Biology - March 28, 2024 Category: Bioinformatics Authors: Luke Pierik Patricia McDonald Alexander R A Anderson Jeffrey West Source Type: research

Meta-DHGNN: method for CRS-related cytokines analysis in CAR-T therapy based on meta-learning directed heterogeneous graph neural network
In this study, we propose Meta-DHGNN, a directed and heterogeneous graph neural network analysis method based on meta-learning. The proposed method integrates both directed and heterogeneous algorithms, while the meta-learning module effectively addresses the issue of limited data availability. This approach enables comprehensive analysis of the cytokine network and accurate prediction of CRS-related cytokines. Firstly, to tackle the challenge posed by small datasets, a pre-training phase is conducted using the meta-learning module. Consequently, the directed algorithm constructs an adjacency matrix that accurately capture...
Source: Briefings in Bioinformatics - March 28, 2024 Category: Bioinformatics Authors: Zhenyu Wei Chengkui Zhao Min Zhang Jiayu Xu Nan Xu Shiwei Wu Xiaohui Xin Lei Yu Weixing Feng Source Type: research

Review and meta-analysis of the genetic Minimal Cut Set approach for gene essentiality prediction in cancer metabolism
Brief Bioinform. 2024 Mar 27;25(3):bbae115. doi: 10.1093/bib/bbae115.ABSTRACTCancer metabolism is a marvellously complex topic, in part, due to the reprogramming of its pathways to self-sustain the malignant phenotype in the disease, to the detriment of its healthy counterpart. Understanding these adjustments can provide novel targeted therapies that could disrupt and impair proliferation of cancerous cells. For this very purpose, genome-scale metabolic models (GEMs) have been developed, with Human1 being the most recent reconstruction of the human metabolism. Based on GEMs, we introduced the genetic Minimal Cut Set (gMCS)...
Source: Briefings in Bioinformatics - March 28, 2024 Category: Bioinformatics Authors: Danel Olaverri-Mendizabal Luis V Valc árcel Naroa Barrena Carlos J Rodr íguez Francisco J Planes Source Type: research

Exploring the diversity of vaginal microbiota between healthy women and cervical cancer patients in India
Conclusion. Differences in the vaginal microbiome between healthy and ICC women could help in the early prediction of cervical cancer risk and thus in designing prevention strategies.PMID:38546452 | DOI:10.1099/jmm.0.001819 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 28, 2024 Category: Microbiology Authors: Ashwini Kamble Shilpa Naik Manju Talathi Deepali Jadhav Meena Sakharkar Jian Yang Om Prakash Ruchika Kaul-Ghanekar Source Type: research

Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis
CONCLUSIONS: Collectively, these findings show that miR-1287-5p/PFN2 signaling was associated with downregulation of circ-SLC16A1 and reduced invasion and proliferation of NSCLC cells. So, circ-SLC16A1 is identified as a mediator of multiple pro-oncogenic signaling pathways in NSCLC and can be targeted to suppress tumor progression.PMID:38539084 | DOI:10.1186/s11658-024-00549-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 28, 2024 Category: Biochemistry Authors: Mingming Jin Tailei Yuan Kaisai Tian Jingjing Li Qingqing Huang Yongbin Chi Gang Huang Source Type: research

Research progress of the netrins and their receptors in cancer
J Cell Mol Med. 2024 Apr;28(8):e18241. doi: 10.1111/jcmm.18241.ABSTRACTNetrins, a family of secreted and membrane-associated proteins, can regulate axonal guidance, morphogenesis, angiogenesis, cell migration, cell survival, and tumorigenesis. Four secreted netrins (netrin 1, 3, 4 and 5) and two glycosylphosphatidylinositols-anchored membrane proteins, netrin-G1 and G2, have been identified in mammals. Netrins and their receptors can serve as a biomarker and molecular therapeutic target for pathological differentiation, diagnosis and prognosis of malignant cancers. We review here the potential roles of the netrins family a...
Source: Molecular Medicine - March 28, 2024 Category: Molecular Biology Authors: Xing Gao Jiazhou Ye Xi Huang Shilin Huang Wenfeng Luo Dandan Zeng Shizhou Li Minchao Tang Rongyun Mai Yongqiang Li Yan Lin Rong Liang Source Type: research

A Novel Methylation-based Model for Prognostic Prediction in Lung Adenocarcinoma
CONCLUSION: This research successfully identified a novel eight-site methylation signature for predicting the overall survival of LUAD patients through bioinformatic integrated analysis of gene methylation markers used in the early diagnosis of lung cancer.PMID:38544827 | PMC:PMC10964088 | DOI:10.2174/0113892029277397231228062412 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Manyuan Li Xufeng Deng Dong Zhou Xiaoqing Liu Jigang Dai Quanxing Liu Source Type: research

Analysis of the Expression of < em > PRDX6 < /em > in Patients with Hepatocellular Carcinoma and its Effect on the Phenotype of Hepatocellular Carcinoma Cells
CONCLUSION: The expression of PRDX6 may be closely related to the prognosis of HCC. Lentivirus-mediated PRDX6 knockdown can inhibit the proliferation, migration and invasion of HCC cells, which may be related to its regulating the PI3K/Akt/mTOR and Notch1 signaling pathways. PRDX6 is expected to be a new target for the diagnosis and treatment of liver cancer.PMID:38544826 | PMC:PMC10964084 | DOI:10.2174/0113892029273682240111052317 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Runhong Mu Mingzhu Chang Chuanbo Feng Yunhe Cui Tingyu Li Chang Liu Yilin Wang Xiao Guo Source Type: research

Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of Exomes
CONCLUSION: Our work provides insights into the various alterations that might possibly lead to colorectal cancer and suggests the possibility of utilizing the most important genes identified for wet-lab experimentation.PMID:38544823 | PMC:PMC10964087 | DOI:10.2174/0113892029285310231227105503 (Source: Current Genomics)
Source: Current Genomics - March 28, 2024 Category: Genetics & Stem Cells Authors: Chandrashekar Karunakaran Vidya Niranjan Anagha S Setlur Dhanya Pradeep Jitendra Kumar Source Type: research

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research

The necroptosis-related signature and tumor microenvironment immune characteristics associated with clinical prognosis and drug sensitivity analysis in stomach adenocarcinoma
CONCLUSIONS: This investigation provides a robust methodological advance in prognosticating and personalizing immunotherapy for STAD, leveraging quantitatively derived tumor cluster risk scores. It posits the use of necroptosis-related lncRNAs as pivotal molecular beacons for guiding therapeutic strategies and enhancing clinical outcomes in STAD.PMID:38546403 | DOI:10.18632/aging.205690 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Biao Yang Yingnan Wang Tao Liu Meijing Zhang Tianhang Luo Source Type: research

Identification of a novel disulfideptosis-related gene signature for prognostic implication in lower-grade gliomas
In conclusion, we discovered a gene signature associated with disulfideptosis that can effectively predict OS in GBMLGG patients. As a result, treating disulfideptosis may be a viable alternative for GBMLGG patients.PMID:38546389 | DOI:10.18632/aging.205688 (Source: Aging)
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Fuqiang Zhang Meihong Lv Yi He Source Type: research

Associations of PD-1 and PD-L1 gene polymorphisms with cancer risk: a meta-analysis based on 50 studies
Aging (Albany NY). 2024 Mar 27;16. doi: 10.18632/aging.205689. Online ahead of print.ABSTRACTProgrammed death-1 and its ligand-1 (PD-1/PD-L1), immune checkpoints proteins, play a crucial role in anti-tumor responses. A large number of studies have evaluated the relationships of PD-1/PD-L1 polymorphisms with risk of cancer, but evidence for the associations remains inconsistent. Therefore, we performed a meta-analysis to examine the associations between PD-1/PD-L1 single nucleotide polymorphisms (SNPs) and cancer predisposition. Results showed that PD-1.3 and PD-L1 rs17718883 were significantly correlated with overall cance...
Source: Aging - March 28, 2024 Category: Biomedical Science Authors: Maoquan Yang Yan Liu Shuangshuang Zheng Peizhen Geng Tianhao He Linan Lu Yikuan Feng Qiqi Jiang Source Type: research