Log in to search using one of your social media accounts:

 

Peptide ligand ‐mediated endocytosis of nanoparticles to cancer cells: cell receptor‐binding‐ vs. cell membrane‐penetrating peptides
This article is protected by copyright. All rights reserved (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - February 20, 2018 Category: Biomedical Science Authors: Eunji Jo, June Seok Heo, Ja ‐Yun Lim, Bo‐Ram Lee, Chul Joo Yoon, Jinkwan Kim, Jeewon Lee Tags: Article Source Type: research

Nano-graphene oxide-UCNP-Ce6 covalently constructed nanocomposites for NIR-mediated bioimaging and PTT/PDT combinatorial therapy
Dalton Trans., 2018, Advance Article DOI: 10.1039/C7DT04141A, PaperArif Gulzar, Jiating Xu, Dan Yang, Liangge Xu, Fei He, Shili Gai, Piaoping Yang NIR light-induced imaging-guided cancer therapy is an encouraging route in the cancer theranostic field. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Dalton Trans. latest articles)
Source: RSC - Dalton Trans. latest articles - February 20, 2018 Category: Chemistry Authors: Arif Gulzar Source Type: research

The mortality-incidence ratio as an indicator of five-year cancer survival in metropolitan Lima.
Conclusion: The Mortality-Incidence Ratio complement [1 - MIR] is an appropriate tool for approximating observed five-year survival for the ten types of cancers studied. This study demonstrates the validity of this model for predicting five-year survival in cancer patients in metropolitan Lima. PMID: 29456616 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

A systematic review of the literature exploring the interplay between prostate cancer and type two diabetes mellitus.
Authors: Crawley D, Chamberlain F, Garmo H, Rudman S, Zethelius B, Holmberg L, Adolfsson J, Stattin P, Carroll P, Van Hemelrijck M Abstract Prostate cancer (PCa) and type two diabetes mellitus (T2DM) are both increasing prevalent conditions and often occur concurrently. However, the relationship between the two is more complex than just two prevalent conditions co-existing. This review systematically explores the literature around the interplay between the two conditions. It covers the impact of pre-existing T2DM on PCa incidence, grade and stage, as well as exploring the impact of T2DM on PCa outcomes and mortalit...
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Endometriosis and endometriosis-associated cancers: new insights into the molecular mechanisms of ovarian cancer development.
Authors: Dawson A, Fernandez ML, Anglesio M, Yong PJ, Carey MS Abstract Endometriosis is a fascinating disease that we strive to better understand. Molecular techniques are shedding new light on many important aspects of this disease: from pathogenesis to the recognition of distinct disease variants like deep infiltrating endometriosis. The observation that endometriosis is a cancer precursor has now been strengthened with the knowledge that mutations that are present in endometriosis-associated cancers can be found in adjacent endometriosis lesions. Recent genomic studies, placed in context, suggest that deep infi...
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Men seeking counselling in a Breast Cancer Risk Evaluation Clinic.
Conclusion: We observed a high adherence to counselling, genetic testing and active surveillance by men belonging to hereditary BC families. Male carriers of pathogenic DNA variants are at risk for several cancers and should be included in prospective follow-up studies. PMID: 29456621 [PubMed] (Source: Ecancermedicalscience)
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Does the oncology community have a rejection bias when it comes to repurposed drugs?
Authors: Gyawali B, Pantziarka P, Crispino S, Bouche G Abstract Among the various measures proposed to combat the challenge of financial toxicity in cancer care, an important strategy is the use of lower-priced drugs instead of expensive alternatives. However, the oncology community seems to either ignore or more readily reject cheaper drugs in cancer care compared to more expensive alternatives. In this commentary, we present three examples of lower-priced drugs rejected or ignored by the oncology community and contrast this with three expensive drugs where persistent optimism remained despite negative clinical tr...
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Osteonecrosis of the jaw (ONJ) in patients who receive Bone Targeting Agents (BTAs): the power of e-learning.
Authors: Nicolatou-Galitis O, Migliorati C Abstract The definition, pathobiology and risk factors of ONJ in cancer patients who receive BTAs are discussed in the recent ecancer module for osteonecrosis of the jaw (http://ecancer.org/education/module/276-osteonecrosis-of-the-jaw.php). ONJ prevention, early diagnosis and management are presented. The critical question of the performance of dental extraction, during BTA therapy, as indicated with the recent studies, is supported. The importance of the collaboration between dental and oncology professionals and the patients is highlighted and can be achieved through ap...
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

The case for a regional approach to publication impact.
Authors: Bruijns S, Lamanna C Abstract Healthcare-related research is largely regional. Put simply, this is because disease burdens differ between world regions. Even global burdens, such as ischaemic heart disease and cancer, display distinctive characteristics in certain regions that are not seen in others. Regional differences in infrastructure, resources and human capital further compound the differences seen, as they affect the way in which the local scientific community can interact with the local disease burden. As such, it seems fair to assume that healthcare-related research ought to be regionally distribu...
Source: Ecancermedicalscience - February 20, 2018 Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research

Estrogen receptor- α promoter methylation is a biomarker for outcome prediction of cisplatin resistance in triple-negative breast cancer.
Estrogen receptor-α promoter methylation is a biomarker for outcome prediction of cisplatin resistance in triple-negative breast cancer. Oncol Lett. 2018 Mar;15(3):2855-2862 Authors: Xu J, Sun T, Guo X, Wang Y, Jing M Abstract A number of previous studies have indicated the presence of a link between estrogen receptor-α (ERα) methylation and triple-negative breast cancer (TNBC). However, the association between ERα methylation and drug resistance during the treatment of TNBC remains unclear. Methylation-specific polymerase chain reaction was used to investigate the methylation o...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-494 inhibits cervical cancer cell proliferation through upregulation of SOCS6 expression.
Authors: Cheng L, Kong B, Zhao Y, Jiang J Abstract It is unclear how microRNA (miR)-494 inhibits the proliferation of cervical cancer cells by altering the expression of SOCS6. Therefore, the present study aimed to investigate the molecular mechanism underlying miR-494 regulation of suppressor of cytokine signaling 6 (SOCS6) in human cervical cancer samples and the human cervical cancer HeLa cell line. The expression of miR-494 was determined using reverse transcription-quantitative polymerase chain reaction. In addition, TargetScan was used to predict miR-494 target genes and the luciferase reporter assay was used...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Combined treatment with D-allose, docetaxel and radiation inhibits the tumor growth in an in vivo model of head and neck cancer.
Authors: Hoshikawa H, Kamitori K, Indo K, Mori T, Kamata M, Takahashi T, Tokuda M Abstract The present study was designed to evaluate the effect of one rare sugar, D-allose, on normal human cells and cutaneous tissue, and to investigate the radiosensitizing and chemosensitizing potential of D-allose in an in vivo model of head and neck cancer. Results indicated that D-allose did not inhibit the growth of normal human fibroblasts TIG-1 cells, and no apoptotic changes were observed after D-allose and D-glucose treatment. The mRNA expression levels of thioredoxin interacting protein (TXNIP) in TIG-1 cells after D-allo...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Fucosterol exhibits selective antitumor anticancer activity against HeLa human cervical cell line by inducing mitochondrial mediated apoptosis, cell cycle migration inhibition and downregulation of m-TOR/PI3K/Akt signalling pathway.
Authors: Jiang H, Li J, Chen A, Li Y, Xia M, Guo P, Yao S, Chen S Abstract Cervical cancer greatly contributes to cancer-associated mortalities worldwide. The growing incidence of cervical cancer is of primary concern, and has signaled the need for multiple treatment options. Despite preliminary responses to chemotherapy and/or surgical interventions, the tumors consistently relapse. Previously, natural products gained attention for their diverse bioactivities, which include however are not limited to, neuroprotective, antimicrobial and anticancer effects. The present study evaluated the anticancer activity of fuco...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR-96 promotes breast cancer metastasis by suppressing MTSS1.
In conclusion, it was identified that miR-96 exhibited an increased level in serum samples of patients with malignant breast cancer in comparison with benign breast tumor types and health controls and may be substantially reduced by chemotherapy treatment, implying that it may be used as a prognostic marker in breast cancer. miR-96 overexpression may inhibit migration of breast cancer cells by downregulating MTSS1 expression. PMID: 29456723 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long noncoding RNA BLACAT1 promotes cell proliferation and invasion in human cervical cancer.
Authors: Shan D, Shang Y, Hu T Abstract Cervical cancer is one of the leading causes of mortality in females worldwide. Predisposition to distant metastasis has reduced the prognosis of this malignancy, thus the identification of a novel agent for metastatic cervical cancer is required. Long noncoding RNAs (LncRNAs) have been reported to serve significant roles in human tumorigenesis. The present study aimed to investigate the effects of a newly discovered LncRNA bladder cancer associated transcript 1 (non-protein coding) (BLACAT1) on cell proliferation and metastasis in cervical cancer. A total of 100 patients wit...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Application of deep learning to the classification of images from colposcopy.
The objective of the present study was to investigate whether deep learning could be applied successfully to the classification of images from colposcopy. For this purpose, a total of 158 patients who underwent conization were enrolled, and medical records and data from the gynecological oncology database were retrospectively reviewed. Deep learning was performed with the Keras neural network and TensorFlow libraries. Using preoperative images from colposcopy as the input data and deep learning technology, the patients were classified into three groups [severe dysplasia, carcinoma in situ (CIS) and invasive cancer (IC)]. A...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Association of histone deacetylase expression with histology and prognosis of ovarian cancer.
Authors: Yano M, Yasuda M, Sakaki M, Nagata K, Fujino T, Arai E, Hasebe T, Miyazawa M, Miyazawa M, Ogane N, Hasegawa K, Narahara H Abstract Histone deacetylase (HDAC) inhibitor is known to have a cytotoxic effect on ovarian cancer cell lines. The present study analyzed the association between immunohistochemical HDAC expression and clinicopathological findings, in particular, the association with histological type and effect of chemotherapy. The histology of the 201 ovarian cancers addressed was as follows: Serous carcinoma (SEC), 100 cases; clear cell carcinoma (CCC), 56 cases; endometrioid carcinoma (EMC), 36 cas...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Values of miR-34a and miR-218 expression in the diagnosis of cervical cancer and the prediction of prognosis.
Authors: Wang P, Zhai G, Bai Y Abstract The expression levels of microribonucleic acid 34a (miR-34a) and miR-218 in the serum and tumor tissues of patients with cervical cancer were investigated to explore their relationship with the diagnosis of cervical cancer. Fifty patients with cervical cancer were selected, and 30 normal patients were selected as the control group. The expression levels of miR-34a and miR-218 were detected by quantitative real-time polymerase chain reaction. The relationship between the expression of miR-34a and miR-218 was analyzed using Pearson's correlation coefficient, and the receiver op...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

The regulation and function of microRNA-377/RASSF8 signaling axis in gastric cancer.
Authors: Bo X, Chen Y, Sheng W, Gong Y, Wang H, Gao W, Zhang B Abstract Gastric cancer is a major cause of cancer-associated mortality worldwide. The aberrant expression of microRNA (miRNA) is involved in tumorigenesis. Ras proteins transfer information from the extracellular environment to internal cellular compartments and are essential in numerous signal transduction pathways. To investigate the regulation, function and clinical significance of the miRNA377/Ras association domain family (RASSF) 8 signaling axis in gastric cancer, reverse transcription-quantitative polymerase chain reaction, immunohistochemistry,...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Analysis of middle- and long-term efficacy of thoracoscope-assisted segmental resection of the lung on non-small cell lung cancer in the early stage.
Authors: Ding N, Zhou N, Li Q, Ren G, Zhou M Abstract We investigated the short- and long-term efficacy of thoracoscope-assisted segmental resection of lung of non-small cell lung cancer (NSCLC). We selected a total of 94 patients with lung cancer in the early stage who were admitted to The First People's Hospital of Xuzhou for treatment between March 2011 and February 2012. Patients were divided randomly into either the control group (n=47) or the observation group (n=47). In the observation group, patients received thoracoscope-assisted segmental resection of lung, while in the control group, the conventional tho...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Two protein-coding genes act as a novel clinical signature to predict prognosis in patients with ovarian serous cystadenocarcinoma.
In conclusion, the expression of the two genes in the two-gene model was associated with the prognostic outcomes of patients with ovarian serous cystadenocarcinoma; the model demonstrated potential as a novel prognostic indicator, which may have important clinical significance. PMID: 29456732 [PubMed] (Source: Oncology Letters)
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Overexpression of flavin-containing monooxygenase 5 predicts poor prognosis in patients with colorectal cancer.
Authors: Zhang T, Yang P, Wei J, Li W, Zhong J, Chen H, Cao J Abstract The present study investigated the expression and clinical significance of flavin-containing monooxygenase 5 (FMO5) in colorectal cancer (CRC). The expression of FMO5 was detected by immunohistochemistry in 208 colon cancer tissues and 8 normal colon tissues. Then, the correlations of FMO5 expression with several clinicopathological features were evaluated. FMO5 mRNA expression from The Cancer Genome Atlas dataset was assessed for further validation. In addition, the association of the expression of FMO5 with prognosis was further evaluated by K...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

miR302a inhibits the proliferation of esophageal cancer cells through the MAPK and PI3K/Akt signaling pathways.
Authors: Xia D, Tian S, Chen Z, Qin W, Liu Q Abstract MicroRNAs (miRNAs/miRs) are involved in the regulation of various types of cancer, either as oncogenes or tumor suppressors. miR302a has been reported that it could suppress tumor cell proliferation by inhibiting Akt in prostate cancer. The present study examined the effect of miR302a on proliferation and invasion in esophageal cancer cell lines. The expression levels of miR302a in esophageal cancer cell lines was determined by reverse transcription-polymerase chain reaction. Subsequently, miR302a mimics were transfected into esophageal cancer cells, and cell vi...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

IL-10 in the microenvironment of HNSCC inhibits the CpG ODN induced IFN- α secretion of pDCs.
IL-10 in the microenvironment of HNSCC inhibits the CpG ODN induced IFN-α secretion of pDCs. Oncol Lett. 2018 Mar;15(3):3985-3990 Authors: Bruchhage KL, Heinrichs S, Wollenberg B, Pries R Abstract It has been shown that head and neck squamous cell carcinoma (HNSCC) are infiltrated by plasmacytoid dendritic cells (pDCs). The HNSCC TH2 biased microenvironment leads to strong alterations of the cellular functions of pDC and thus impairs the initiation and function of adequate immune responses. In this work we comprehensively analyzed the capacity of CpG-oligonucleotides to activate interferon (IFN)-...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Cardamonin enhances the anti-proliferative effect of cisplatin on ovarian cancer.
Authors: Niu P, Shi D, Zhang S, Zhu Y, Zhou J Abstract The mammalian target of rapamycin (mTOR) is well-known as a promising therapeutic target in various cancer cells. mTOR activation decreases the sensitivity of ovarian cancer to cisplatin. Cardamonin inhibits the proliferation of various cancer cells by mTOR suppression. The present study examined whether cardamonin combined with cisplatin is efficacious for the anti-proliferation of ovarian cancer cells. The anti-proliferative effect was determined by MTT and cell cycle assays. Activation of the mTOR signal pathway and the expression of anti-apoptotic proteins ...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

An obligatory anaerobic Salmonella typhimurium strain redirects M2 macrophages to the M1 phenotype.
Authors: Yang M, Xu J, Wang Q, Zhang AQ, Wang K Abstract A genetically engineered Salmonella typhimurium strain that may be applied in the medically useful therapeutic strategy of using bacterial agents to target breast cancer in a tumor-bearing nude mouse model has been previously reported. Furthermore, immune cell accumulation in breast tumor types has been observed, particularly distributed in regions surrounding the bacteria. M2 macrophages are associated with breast cancer aggressiveness, whereas M1 macrophages are prone to devouring bacteria and killing cancer cells. Therefore, this engineered tumor-targeting...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAFV600E mutations.
Authors: Zhi J, Li Z, Lv J, Feng B, Yang D, Xue L, Zhao Z, Zhang Y, Wu J, Jv Y, Jia Y Abstract It remains unknown whether blockade of B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E signaling and MET proto-oncogene, receptor tyrosine kinase (c-Met) signaling is effective in suppressing the growth of human colorectal cancer (CRC) cells. The present study investigated the effects of the vemurafenib alone and in combination with c-Met inhibitor PHA-665752 on the growth of human CRC cells in vitro and in mouse xenografts. HT-29 and RKO CRC cell lines with BRAFV600E mutations and mice bearing HT-29 xenografts ...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Distinctive profiles of tumor-infiltrating immune cells and association with intensity of infiltration in colorectal cancer.
Authors: Wu Y, Yuan L, Lu Q, Xu H, He X Abstract Tumor-infiltrating immune cells are heterogeneous and consist of characteristic compartments, including T helper (Th)1 and regulatory T (Treg) cells that exhibit distinctive biological functions. The present study investigated the profile of infiltrating immune cells from surgically removed tumor tissues from patients with colorectal cancer. The characteristic transcription factors of Th1 and Th2 cells, Treg cells, Th17 cells and T follicular helper (Tfh) cells were analyzed. The results demonstrated that a marked increased number of Treg cells presented in tumor inf...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Sp5 negatively regulates the proliferation of HCT116 cells by upregulating the transcription of p27.
Authors: Miyamoto M, Hayashi T, Kawasaki Y, Akiyama T Abstract The Wnt signaling pathway is aberrantly activated in the majority of human colorectal tumors. β-catenin, a key component of the Wnt signaling pathway, interacts with the T-cell factor/lymphoid enhancer-binding factor family of transcription factors and activates transcription of Wnt target genes. Sp5 is one of the Wnt target genes, and its expression is commonly upregulated in colon cancer cells. The present study demonstrates that the expression of Sp5 is not upregulated in the colon cancer cell line HCT116, in which Wnt signaling is constitutivel...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Brucea javanica seed oil enhances the radiosensitivity of esophageal cancer by inhibiting hypoxia-inducible factor 1 α, in vitro and in vivo.
Brucea javanica seed oil enhances the radiosensitivity of esophageal cancer by inhibiting hypoxia-inducible factor 1α, in vitro and in vivo. Oncol Lett. 2018 Mar;15(3):3870-3875 Authors: Pan P, Yang BX, Ge XL Abstract Brucea javanica oil emulsion (BJOE) has been used clinically to treat esophageal cancer combined with radiotherapy for numerous years in China. However, the detailed mechanism remains unclear. Thus, the effects of BJOE on the radiosensitivity of esophageal squamous cell carcinoma (ESCC) were evaluated in vitro and in vivo. The growth inhibitory effects of different BJOE concentratio...
Source: Oncology Letters - February 20, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Population based testing of non ‐mucinous epithelial ovarian cancer in Scotland
Abstract Rust and colleagues provide strong support for the extension of BRCA1/2 germline testing to all high grade serous ovarian cancer (HGSOC) cases regardless of family history (Rust et al, BJOG 2018). The reflex testing of all consenting cases uncovered the deficiencies of the previous system whereby many women with a family history in the prevalent population of previous ovarian cancer were not tested despite having a Manchester score of ≥15, equivalent to a 10% detection rate or greater of a BRCA1/2 pathogenic variant (Evans et al, J Med Genet 2017;54:674‐681). Although all HGSOC
Source: BJOG: An International Journal of Obstetrics and Gynaecology - February 20, 2018 Category: OBGYN Authors: D.G Evans, R Edmondson, E.J Crosbie Tags: Mini ‐commentary Source Type: research

Metformin and aspirin treatment could lead to an improved survival rate for Type 2 diabetic patients with stage II and III colorectal adenocarcinoma relative to non-diabetic patients.
Abstract Metformin, the drug of choice in the treatment of type 2 diabetes mellitus (DM2), in addition to aspirin (ASA), the drug prescribed for cardioprotection of diabetic and non-diabetic patients, have an inhibitory effect on cancer cell survival. The present population-based study conducted in the province of Trieste (Italy), aimed to investigate the prevalence of DM2 in patients with colorectal adenocarcinoma (CRC) and survival for CRC in diabetic and nondiabetic patients. All permanent residents diagnosed with a CRC between 2004 and 2007 were ascertained through the regional health information system. CRC-s...
Source: Clinical Colorectal Cancer - February 20, 2018 Category: Cancer & Oncology Authors: De Monte A, Brunetti D, Cattin L, Lavanda F, Naibo E, Malagoli M, Stanta G, Bonin S Tags: Mol Clin Oncol Source Type: research

Crizotinib-associated toxic epidermal necrolysis in an ALK-positive advanced NSCLC patient.
Abstract Crizotinib is an oral small-molecule inhibitor of anaplastic lymphoma kinase (ALK) tyrosine-kinase that has been approved for treating patients with advanced echinoderm microtubule associated protein like 4-ALK rearranged non-small-cell lung cancer (NSCLC). Toxic epidermal necrolysis (TEN) is a rare adverse event associated with crizotinib. The present study reported a case of a 75-year-old Chinese male patient with advanced NSCLC with ALK fusion, who developed TEN after 56 days of crizotinib treatment and demised due to this dermatological adverse event. The occurrence of severe cutaneous necrolysis that...
Source: Clinical Lung Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Yang S, Wu L, Li X, Huang J, Zhong J, Chen X Tags: Mol Clin Oncol Source Type: research

Alcohol consumption and risk of hematological malignancies: A meta ‐analysis of prospective studies
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Theodora Psaltopoulou, Theodoros N. Sergentanis, Ioannis Ntanasis ‐Stathopoulos, Ioannis‐Georgios Tzanninis, Diamantis I. Tsilimigras, Meletios A. Dimopoulos Tags: Research Article Source Type: research

Centralization errors in comparative genomic hybridization array analysis of pituitary tumor samples
This article is protected by copyright. All rights reserved. (Source: Genes, Chromosomes and Cancer)
Source: Genes, Chromosomes and Cancer - February 20, 2018 Category: Cancer & Oncology Authors: H élène Lasolle, Eudeline Alix, Clémentt Bonnefille, Mad‐Hélénie. Elsensohn, Jessica Michel, Damien Sanlaville, Pascal Roy, Gérald Raverot, Claire Bardel Tags: Research Article Source Type: research

Checkpoint Inhibitors in Breast Cancer - Current Status and Future Directions
Breast Care (Source: Breast Care)
Source: Breast Care - February 20, 2018 Category: Cancer & Oncology Source Type: research

Extracorporeal Stimulation of Sacral Nerve Roots for Observation of Pelvic Autonomic Nerve Integrity: Description of a Novel Methodological Setup
Conclusion: The system delivered stable electric current, which was proved by built-in impedance and current level measurements. Intra-anal sEMG confirmed the ability to target the branches of the autonomous nervous system originating from the sacral nerve roots. Significance: Stimulation outside of t- e operative field during rectal cancer surgery is feasible and may improve the practicality of pelvic intraoperative neuromonitoring. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - February 20, 2018 Category: Biomedical Engineering Source Type: research

Extent of lymph node dissection improves survival in prostate cancer patients treated with radical prostatectomy without lymph node invasion
ConclusionMore extensive PLND at RP provides improved staging information and consequently is associated with lower CSM in D'Amico intermediate‐ and high‐risk PCa patients without evidence of LNI. Hence, more extensive PLND should be recommended in such individuals. (Source: The Prostate)
Source: The Prostate - February 20, 2018 Category: Urology & Nephrology Authors: Felix Preisser, Marco Bandini, Michele Marchioni, Sebastiano Nazzani, Zhe Tian, Raisa S. Pompe, Nicola Fossati, Alberto Briganti, Fred Saad, Shahrokh F. Shariat, Hans Heinzer, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I. Karakiewicz Tags: ORIGINAL ARTICLE Source Type: research

miRNA ‐124‐3p/neuropilin‐1(NRP‐1) axis plays an important role in mediating glioblastoma growth and angiogenesis
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Guilong Zhang, Lukui Chen, Ahsan Ali Khan, Bingqian Li, Bin Gu, Fan Lin, Xinhui Su, Jianghua Yan Tags: Research Article Source Type: research

Tumor Targeting via Sialic Acid: [ 68 Ga]DOTA-en-pba as a New Tool for Molecular Imaging of Cancer with PET
ConclusionsOur work is the first attempt forin vivo imaging of cancer by targeting overexpression of sialic acid on cancer cells with a radiotracer in PET. (Source: Molecular Imaging and Biology)
Source: Molecular Imaging and Biology - February 20, 2018 Category: Molecular Biology Source Type: research

Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway
5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2018 Category: Molecular Biology Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu and John C. Schmitz Tags: Research Source Type: research

HMGB2 is associated with malignancy and regulates Warburg effect by targeting LDHB and FBP1 in breast cancer
High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2018 Category: Molecular Biology Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren Tags: Research Source Type: research

Night shift work and breast cancer: a pooled analysis of population-based case –control studies with complete work history
AbstractNight shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment of exposure to night work. To overcome this limitation, we pooled data of five population-based case –control studies from Australia, Canada, France, Germany, and Spain into a single harmonized dataset using a common definition of night work including 6093 breast cancer cases and 6933 population controls. The odds ratio for breast cancer in women who ever worked at night for at least 3 h between midnight and 5 a.m. as compared to never night workers was 1.12 (95...
Source: European Journal of Epidemiology - February 20, 2018 Category: Epidemiology Source Type: research

Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis
ConclusionThese findings of the meta-analysis suggest that HOTAIR polymorphism may contribute to cancer susceptibility. (Source: Environmental Health and Preventive Medicine)
Source: Environmental Health and Preventive Medicine - February 20, 2018 Category: Environmental Health Source Type: research

A Reduction-sensitive Thermo-responsive Polymer: Synthesis, Characterization, and Application in Controlled Drug Release
Publication date: Available online 20 February 2018 Source:European Polymer Journal Author(s): Li Song, Bao Zhang, E Jin, Chunsheng Xiao, Gao Li, Xuesi Chen Herein, a novel kind of reduction and thermal dual-responsive polymer was synthesized by direct condensation polymerization of poly(ethylene glycol) (PEG) and 3,3'-dithiodipropanoic acid (DTPA). The resulting PEG-DTPA copolymers were soluble in water at room temperature and exhibited reversible thermal-responsive behaviors. The cloud point temperatures of PEG-DTPA copolymers were highly tunable dependent on the polymer concentration and the length of PEG segment. Addi...
Source: European Polymer Journal - February 20, 2018 Category: Chemistry Source Type: research

Protocol of thermal aging against the swelling of poly(dimethylsiloxane) and physical insight in swelling regimes
This study: i) provides practical guidelines for performing optimal thermal aging treatments of PDMS against swelling (for example, in microfluidic platforms to synthesize cancer tracers), and ii) contributes to the fundamental understanding of the swelling process of soft matter systems. An interpretative model has been developed of the observed swelling regimes based on heating-promoted crosslinking and chain reorganization (inter-chain mobility) at short-lasting heating timescales and conformational changes (intra-chains transitions) at long-lasting heating timescales. Graphical abstract (Source: Polymer)
Source: Polymer - February 20, 2018 Category: Chemistry Source Type: research

Significant influence of GSTP1 Gene Ile105Val polymorphic sequence variation for elevated risk in predisposition to malignant glioma
Conclusion Our study shows that both allelic and genotypic variants of GSTP1 Ile105Val is strongly associated with higher risk to glioma in our population and further valine-related variant allele is connected with higher susceptibility to the disease in smokers. (Source: Meta Gene)
Source: Meta Gene - February 20, 2018 Category: Genetics & Stem Cells Source Type: research

The BRCA2 c.68 ‐7T  >  A variant is not pathogenic: A model for clinical calibration of spliceogenicity
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - February 20, 2018 Category: Genetics & Stem Cells Authors: Mara Colombo, Irene L òpez‐Perolio, Huong D. Meeks, Laura Caleca, Michael Parsons, Hongyan Li, Giovanna Vecchi, Emma Tudini, Claudia Foglia, Patrizia Mondini, Siranoush Manoukian, Raquel Behar, Encarna B. Gomez Garcia, Alfons Meindl, Marco Montagna, Di Tags: RESEARCH ARTICLE Source Type: research

GRK5 functions as an oncogenic factor in non-small-cell lung cancer
GRK5 functions as an oncogenic factor in non-small-cell lung cancer, Published online: 20 February 2018; doi:10.1038/s41419-018-0299-1GRK5 functions as an oncogenic factor in non-small-cell lung cancer (Source: Cell death and disease)
Source: Cell death and disease - February 20, 2018 Category: Internal Medicine Authors: Li-Ping Jiang Song-Qing Fan Qiu-Xia Xiong Yong-Chun Zhou Zuo-Zhang Yang Gao-Feng Li Yun-Chao Huang Meng-Ge Wu Qiu-Shuo Shen Kun Liu Cui-Ping Yang Yong-Bin Chen Source Type: research

Barrier to autointegration factor 1, procollagen ‐lysine, 2‐oxoglutarate 5‐dioxygenase 3, and splicing factor 3b subunit 4 as early‐stage cancer decision markers and drivers of hepatocellular carcinoma
Conclusion: The findings suggest molecular markers of BANF1, PLOD3, and SF3B4 indicating early‐stage HCC in precancerous lesion, and also suggest drivers for understanding the development of hepatocarcinogenesis. (Hepatology 2017). (Source: Hepatology)
Source: Hepatology - February 20, 2018 Category: Internal Medicine Authors: Qingyu Shen, Jung Woo Eun, Kyungbun Lee, Hyung Seok Kim, Hee Doo Yang, Sang Yean Kim, Eun Kyung Lee, Taemook Kim, Keunsoo Kang, Seongchan Kim, Dal ‐Hee Min, Soon‐Nam Oh, Young‐Joon Lee, Hyuk Moon, Simon Weonsang Ro, Won Sang Park, Jung Young Lee, Su Tags: Hepatobiliary Malignancies Source Type: research