Factors Associated with Decision to Undergo Contralateral Prophylactic Mastectomy versus Unilateral Mastectomy
ConclusionsBoth UM and CPM patients reported high satisfaction with their surgical decisions, despite differing reasons for their respective surgeries. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - December 9, 2018 Category: Surgery Source Type: research

Four hundred fifty-three consecutive pancreaticoduodenectomies with pancreaticogastrostomy
ConclusionsThis series of patients undergoing PD with PG shows that the operation can be performed safely with excellent outcomes for a variety of malignant and benign conditions. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - December 9, 2018 Category: Surgery Source Type: research

Off-clamp vs on-clamp robotic partial nephrectomy: Perioperative, functional and oncological outcomes from a propensity-score matching between two high-volume centers
ConclusionWe confirm no significant differences in the perioperative and oncological outcomes between off-clamp and on-clamp RPN. Avoided ischemia benefits renal function within 1-year follow-up after surgery. At longer follow-up, difference with on-clamp is softened. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - December 9, 2018 Category: Surgery Source Type: research

Invitation to Screening Colonoscopy in the Population at Familial Risk for Colorectal Cancer.
CONCLUSION: Additional counseling by nurses over the telephone does not increase the participation rate. Approaching patients who have CRC is an opportunity to increase the participation of their first-degree relatives in screening colonoscopy. The frequency of neoplasia that was found in this study underscores the need to screen relatives even before they reach the usual age threshold for screening. PMID: 30518470 [PubMed - in process] (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - December 9, 2018 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Image-Enhanced Endoscopy in Lower Gastrointestinal Diseases: Present and Future.
Authors: Lee HH, Lee BI Abstract From dye-assisted conventional chromoendoscopy to novel virtual chromoendoscopy, image-enhanced endoscopy (IEE) is continuously evolving to meet clinical needs and improve the quality of colonoscopy. Dye-assisted chromoendoscopy using indigo carmine or crystal violet, although slightly old-fashioned, is still useful to emphasize the pit patterns of the colonic mucosa and predict the histological structures of relevant lesions. Equipment-based virtual chromoendoscopy has the advantage of being relatively easy to use. There are several types of virtual chromoendoscopy that vary depend...
Source: Clinical Endoscopy - December 9, 2018 Category: Gastroenterology Tags: Clin Endosc Source Type: research

Gastric sub-epithelial tumors: identification of gastrointestinal stromal tumors using CT with a practical scoring method
AbstractObjectivesTo determine CT features that can identify gastrointestinal stromal tumors (GISTs) among gastric sub-epithelial tumors (SETs) and to explore a practical scoring method.MethodsSixty-four patients with gastric SETs (51 GISTs and 13 non-GISTs) from hospital I were included for primary analyses, and 92 (67 GISTs and 25 non-GISTs) from hospital II constituted a validation cohort. Pre-operative CT images were reviewed for imaging features: lesion location, growth pattern, lesion margin, enhancement pattern, dynamic pattern, attenuation at each phasic images and presence of necrosis, superficial ulcer, calcifica...
Source: Gastric Cancer - December 9, 2018 Category: Gastroenterology Source Type: research

Cancers, Vol. 10, Pages 500: Mitochondrial RNA Expression and Single Nucleotide Variants in Association with Clinical Parameters in Primary Breast Cancers
. Martens The human mitochondrial DNA (mtDNA) encodes 37 genes, including thirteen proteins essential for the respiratory chain, and RNAs functioning in the mitochondrial translation apparatus. The total number of mtDNA molecules per cell (mtDNA content) is variable between tissue types and also between tumors and their normal counterparts. For breast cancer, tumors tend to be depleted in their mtDNA content compared to adjacent normal mammary tissue. Various studies have shown that primary breast tumors harbor somatic mtDNA variants. A decrease in mtDNA content or the presence of somatic variants could indicate a redu...
Source: Cancers - December 9, 2018 Category: Cancer & Oncology Authors: Marjolein J. A. Weerts Marcel Smid John A. Foekens Stefan Sleijfer John W. M. Martens Tags: Article Source Type: research

Comprehensive genetic alteration profiling in primary and recurrent glioblastoma
ConclusionsCGP revealed that GA identified in GBM changed over time and with treatment. Mutations inTERT, CDKN2A/CDKN2B, EGFR, and PI3K pathway were commonly observed in both primary and recurrent GBM revealing their prognostic and therapeutic potential. This may have important implications for individualized therapies and needs further evaluation. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - December 9, 2018 Category: Cancer & Oncology Source Type: research

The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice
In this study, we have generated and characterised congenic mice that contain the BALB/c SuprMam1 (susceptibility) locus on a C57BL/6 (resistant) background and discovered a subtle impairment in the vitamin D/ calcium/ parathyroid hormone (PTH) pathway. This was evident as altered gene expression in the mammary glands of key players in this pathway. Further functional analysis of the mice revealed elevated PTH levels, reduced Cyp27b1 expression in kidneys, and reduced trabecular bone volume/ tissue volume percentage. Plasma 25(OH)D and serum calcium were unchanged. This impairment was a result of genetic differences and oc...
Source: The Journal of Steroid Biochemistry and Molecular Biology - December 8, 2018 Category: Biochemistry Source Type: research

Synthesis and anticancer property of Zn(II) compounds nanoparticles based on tetrazole carboxylate ligands
Publication date: 1 March 2019Source: Inorganica Chimica Acta, Volume 487Author(s): Ting Zhu, Tian Yu Wu, Jing Ao Ren, Su Jian Qian, Yan Li, Wan Ting Su, Deng Feng Zou, Qiao Yun Li, Jie YangAbstractTwo new coordination compounds, [Zn(pytzipa)2(H2O)4]·2H2O (1) and [Zn2(dtzpda)(H2O)5]·3H2O (2) have been synthesized by solvothermal reactions of Zn(NO3)2·6H2O with Hpytzipa or H4dtzpda, respectively (Hpytzipa = 5-(3-pyridyl)tetrazole-2-isoproponaic acid, H4dtzpda = 3,3-di(1H-tetrazol-5-yl)pentanedioic acid). The X-ray diffraction results reveal that compound 1 is a linear chain in which pytzipa acts...
Source: Inorganica Chimica Acta - December 8, 2018 Category: Chemistry Source Type: research

DNA damage checkpoint response to aflatoxin B1
Publication date: Available online 7 December 2018Source: Environmental Toxicology and PharmacologyAuthor(s): Ayse Basak Engin, Atilla EnginAbstractAlthough most countries regulate the aflatoxin levels in food by legislations, high amounts of aflatoxin B1 (AFB1)-DNA adducts can still be detected in normal and tumorous tissue obtained from cancer patients. AFB1 cannot directly interact with DNA unless it is biotransformed to AFB1-8, 9-epoxide via cytochrome p450 enzymes. This metabolite spontaneously and irreversibly attaches to guanine residues to generate highly mutagenic DNA adducts. AFB1-induced mutation of ATM kinase r...
Source: Environmental Toxicology and Pharmacology - December 8, 2018 Category: Environmental Health Source Type: research

Mesoporous silica nanoparticles: a versatile platform for biomedical applications.
CONCLUSION: The future success of MSNs is widened because of their valuable characteristic which easily combines with various functionalities which would display enormous potential translational possibilities. PMID: 30501606 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 8, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Trends in the clinical presentation, treatment, and survival for pancreatic adenocarcinoma
ConclusionsThere have been significant improvements in pancreatic cancer care over the last decade, as evidenced by earlier diagnosis, increased utilization of surgery, and improvement in overall survival for both resected and un-resected patients. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - December 8, 2018 Category: Surgery Source Type: research

Inflammatory breast cancer: Activation of the aryl hydrocarbon receptor and its target CYP1B1 correlates closely with Wnt5a/b-β-catenin signalling, the stem cell phenotype and disease progression
Publication date: Available online 8 December 2018Source: Journal of Advanced ResearchAuthor(s): Hossam T. Mohamed, Ramy Gadalla, Noura El-Husseiny, Hebatallah Hassan, Zhongyan Wang, Sherif A. Ibrahim, Mohamed El-Shinawi, David H. Sherr, Mona M. MohamedAbstractThe aim of the present study was to evaluate the expression levels of the aryl hydrocarbon receptor (AHR) and its target gene CYP1B1 and to correlate their expression with Wnt5a/b-β-catenin, the CD44+/CD24(-/low) cancer stem cell (CSC) subset and factors associated with poor prognosis in inflammatory breast cancer (IBC) and non-IBC patients. The methods of analy...
Source: Journal of Advanced Research - December 8, 2018 Category: Research Source Type: research

Learner’s perception, knowledge and behaviour assessment within a breast imaging eLearning course for radiographers
ConclusionThese global results show that e-learning can provide statistically relevant knowledge gains in Radiographers. This course is an important contribution to the improvement of mammography education, impacting on the development of students' and radiographers’ skills. (Source: European Journal of Radiology)
Source: European Journal of Radiology - December 8, 2018 Category: Radiology Source Type: research

Minimally Invasive Surgery for Resection of Diaphragm Metastases in Ovarian Cancer
ConclusionsResection of diaphragm metastases by MIS appears to be feasible and safe for selected patients, with similar recurrence as other abdominal sites. (Source: Journal of Minimally Invasive Gynecology)
Source: Journal of Minimally Invasive Gynecology - December 8, 2018 Category: OBGYN Source Type: research

Peripherally inserted central catheter, midline, and "short" midline in palliative care: Patient-reported outcome measures to assess impact on quality of care.
Peripherally inserted central catheter, midline, and "short" midline in palliative care: Patient-reported outcome measures to assess impact on quality of care. J Vasc Access. 2018 Dec 03;:1129729818814732 Authors: Magnani C, Calvieri A, Giannarelli D, Espino M, Casale G Abstract OBJECTIVES:: A prospective, observational study was conducted in our palliative care unit to assess the impact of peripherally inserted central catheters (PICCs), midline, and "short" midline catheters on the quality of care in cancer and non-cancer patients. The secondary objective was to assess pain and di...
Source: The Journal of Vascular Access - December 8, 2018 Category: Surgery Tags: J Vasc Access Source Type: research

A Simple Guideline to Assess the Characteristics of RNA-Seq Data.
In this study, we provide a simple method that can intuitively evaluate RNA-seq data using two different principal component analysis (PCA) plots. The gene expression PCA plot provides insights into the association between samples, while the transcript integrity number (TIN) score plot provides a quality map of given RNA-seq data. With this approach, we found that RNA-seq datasets deposited in public repositories often contain a few low-quality RNA-seq data that can lead to misinterpretations. The effect of sampling errors for differentially expressed gene (DEG) analysis was evaluated with ten RNA-seq data from invasive du...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Son K, Yu S, Shin W, Han K, Kang K Tags: Biomed Res Int Source Type: research

Derivation and Validation of the Potential Core Genes in Pancreatic Cancer for Tumor-Stroma Crosstalk.
Conclusions: These results identified the potential core genes and pathways in pancreatic cancer for tumor-stroma crosstalk, which could provide potential targets for the treatment of pancreatic cancer. PMID: 30519576 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Xue R, Hua L, Xu W, Gao Y, Pang Y, Hao J Tags: Biomed Res Int Source Type: research

Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial.
Abstract Background: Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer. Methods: Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014. The included patients were randomly assigned to either receive CO2-LS (n=65) or LTP-RFA (n=66). We conducted the following multidimensional vocal assessments...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Zhang Y, Wang B, Sun G, Zhang G, Lu L, Liang G Tags: Biomed Res Int Source Type: research

CX-3543 Promotes Cell Apoptosis through Downregulation of CCAT1 in Colon Cancer Cells.
Conclusion: Our study demonstrated that CX3543 could inhibit the progression of colon cancer by downregulating CCAT1 expression and might be a potential drug for the treatment of colon cancer. PMID: 30519593 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Yao YX, Xu BH, Zhang Y Tags: Biomed Res Int Source Type: research

Effect of Comorbidity on Lung Cancer Diagnosis Timing and Mortality: A Nationwide Population-Based Cohort Study in Taiwan.
This study collected various comorbidity patients and analyzed data regarding the lung cancer diagnosis and survival during a 16-year follow-up period (1995-2010). In total, 101,776 lung cancer patients were included, comprising 44,770 with and 57,006 without comorbidity. The Kaplan-Meier analyses were used to compare overall survival between lung cancer patients with and without comorbidity. In our cohort, chronic bronchitis patients who developed lung cancer had the lowest overall survival in one (45%), five (28.6%), and ten years (26.2%) since lung cancer diagnosis. Among lung cancer patients with nonpulmonary comorbidi...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Dima S, Chen KH, Wang KJ, Wang KM, Teng NC Tags: Biomed Res Int Source Type: research

Impact of Health Information Prescription on Self-care of Women with Breast Cancer.
Abstract Background: Women with breast cancer experience various challenges. Prescription of health information provides appropriate information at appropriate time to the appropriate person and plays a role in empowering self-care and improving health. The current research aims to evaluate the effect of health information prescription on self-care power of women with breast cancer. Materials and Methods: This semi-experimental quantitative study was done using pretest and posttest method in one group of 61 women with breast cancer selected from the Women's Cancer Center of Khatamolanbia Hospital using purpos...
Source: Biomed Res - December 8, 2018 Category: Research Authors: Latifi M, Alishan Karami N, Beiraghdar M, Maraki F, Allahbakhshian Farsani L Tags: Adv Biomed Res Source Type: research

Osteoradionecrosis of the hyoid bone complicated by pharyngocutaneous fistula: A case report and literature review
ConclusionsHyoid ORN should remain in the differential during diagnostic workup of previously irradiated head and neck cancer patients. The presentation of a pharyngocutaneous fistula should prompt workup to rule out malignancy before assigning a diagnosis of ORN. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - December 8, 2018 Category: Endocrinology Source Type: research

Pharmacokinetic evaluation, molecular docking and in vitro biological evaluation of 1, 3, 4-oxadiazole derivatives as potent antioxidants and STAT3 inhibitors
Publication date: Available online 7 December 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Rashmin khanam, Iram I. Hejazi, Syed Shahabuddin, Abdul R. Bhat, Fareeda AtharAbstract1, 3, 4-Oxadiazole derivatives (4a-5f) were previously synthesized to investigate their anticancer properties. However, studies relating to their antioxidant potential and signal transducer and activator of transcription (STAT) inhibition have not been performed. We investigated previously synthesized 1, 3, 4-oxadiazole derivatives (4a-5f) for various radical scavenging properties using several in vitro antioxidant assays and also for di...
Source: Journal of Pharmaceutical Analysis - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-let-7e inhibits invasion and magration and regulates HMGB1 expression in papillary thyroid carcinoma
In this study, we showed that the overexpression of miR-let-7e or knockdown of high mobility group box 1 (HMGB1) inhibited cell migration and invasion. MiR-let-7e downregulates HMGB1 expression by directly targeting the HMGB1 3′-UTR. Furthermore, HMGB1 reintroduction reversed the anti-proliferation, anti-migration, and anti-invasion roles of miR-let-7e. miR-let-7e might function as a tumor suppressor in papillary thyroid carcinoma through HMGB1. Therefore, our study demonstrates that miR-let-7e plays an important role in papillary thyroid carcinoma progression and might represent a new potential therapeutic target fo...
Source: Biomedicine and Pharmacotherapy - December 8, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Tumor Location and Dosimetric Predictors for Chest Wall Toxicity in Single Fraction SBRT for Stage I Non-Small Cell Lung Cancer
ConclusionRate of CWT with SF-SBRT is similar to rates published for fractionated SBRT, with most CWT being low grade. Tumor location relative to CW is not a contraindication to SF-SBRT, though rates rise significantly with abutment. Rib D1cc and CW D1cc and D5cc may be used as predictors of CWT. (Source: Practical Radiation Oncology)
Source: Practical Radiation Oncology - December 8, 2018 Category: Cancer & Oncology Source Type: research

Outcomes and characteristics of patients treated with emergent palliative radiotherapy
This study is a cross-sectional retrospective analysis of all emergent palliative radiotherapy courses at a single academic tertiary institution across one year.Results214 patients received a total of 238 treatment courses. The most common indications were bone (39%) and brain (14%) metastases. Compared to outpatients, inpatients had lower mean survival (2 months vs 6 months, p
Source: Practical Radiation Oncology - December 8, 2018 Category: Cancer & Oncology Source Type: research

The Clinical and Prognostic Significance of FIS1, SPI1, PDCD7 and Ang2 Expression Levels in Acute Myeloid Leukemia
Publication date: Available online 7 December 2018Source: Cancer GeneticsAuthor(s): Reham Abo Elwafa, Marwa Gamaleldin, Omar GhallabAbstractObjectivesThe marked heterogeneity of acute myeloid leukemia (AML) renders precisely predicting patient prognosis extremely difficult. Genetic alterations, fusions and mutations, may result in misexpression of key genes in AML. We aimed to investigate the expression patterns of 4 novel genes; FIS1, SPI1, PDCD7 and Ang2 to determine their potential prognostic role in AML patients.MethodsBone marrow mononuclear cells were analyzed for of FIS1, SPI1, PDCD7 and Ang2 expression levels by re...
Source: Cancer Genetics - December 8, 2018 Category: Cancer & Oncology Source Type: research

Phycocyanin functionalized single-walled carbon nanohorns hybrid for near-infrared light-mediated cancer phototheranostics
Publication date: March 2019Source: Carbon, Volume 143Author(s): Zhaoxing Lin, Bang-Ping Jiang, Jinzhe Liang, Changchun Wen, Xing-Can ShenAbstractApplication of carbon nanomaterials to near-infrared light-mediated phototherapy has attracted great interest. However, their practical use in biological systems is severely limited by their poor water dispersibility, inevitable adsorption of plasma proteins, and their single therapeutic function. Herein, we prepared a phycocyanin (PC)-functionalized single-walled carbon nanohorns (PC@SWNHs) hybrid, where PC is used to preform a protein corona around the SWNHs through non-covalen...
Source: Carbon - December 8, 2018 Category: Materials Science Source Type: research

LINC01118 Modulates Paclitaxel Resistance of Epithelial Ovarian Cancer by Regulating miR-134/ABCC1.
CONCLUSIONS LINC01118 acted as an oncogene and modulated EOC paclitaxel sensitivity by regulating miR-134/ABCC1. PMID: 30521500 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Long Noncoding RNA Plasmacytoma Variant Translocation 1 (PVT1) Promotes Colon Cancer Progression via Endogenous Sponging miR-26b.
CONCLUSIONS Our results suggest that PVT1 could promote metastasis and proliferation of colon cancer via endogenous sponging and inhibiting the expression of miR-26b, which may highlight the significance of lncRNA PVT1 in colon cancer tumorigenesis. PMID: 30504754 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - December 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Molecular Staging of Patients with Colon Cancer. The C-Closer-II Study: A Multicentre Study in Portugal.
CONCLUSION: In our study, 28.8% of patients with histologically negative lymph nodes were found to have metastatic lymph nodes using OSNA - one step nucleic acid molecular assessment. OSNA - one step nucleic acid assay allows a more accurate staging of patients with colorectal cancer and standardizes lymph node assessment. PMID: 30521460 [PubMed - in process] (Source: Acta Medica Portuguesa)
Source: Acta Medica Portuguesa - December 8, 2018 Category: General Medicine Tags: Acta Med Port Source Type: research

RNA-seq Analysis of The SCN1A-KO Model Based on CRISPR/Cas9 Genome Editing Technology
In this study, we constructed an SCN1A gene knockout model using CRISPR/Cas9 genome editing technology to deprive the Nav1.1 function in vitro. With mRNA-seq analysis we found abundant gene changes after SCN1A knockout, which associated with various signaling pathways, such as cancer pathways, the PI3K-AKT signaling pathway, the MAPK signaling pathway, and pathways involved in HTLV-I infection. We also noticed changes in the spliceosome, decreased glycolytic capacity, disturbances in calcium signaling pathways, and changes in the potassium, sodium, chloride, and calcium plasma channels after SCN1A knockout. In this study, ...
Source: Neuroscience - December 8, 2018 Category: Neuroscience Source Type: research

Trends in the incidence and mortality of cancer in Saudi Arabia.
Conclusion: The increases in the incidence of different types of cancer in the past decade could be due to the revolutionary change in socioeconomic status that has occurred in Saudi Arabia; therefore, a national plan should be established for cancer prevention, screening and therapy. Concerning mortality, the decrease in its percentage among elderly people could be due to biological factors that should be investigated in the future. PMID: 30520511 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - December 8, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research

[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events].
Abstract Although many people (and patients) in Japan currently consume health foods such as supplements, few have proper knowledge of their usefulness and safety. In December 2015, the Food Safety Commission of Japan issued a report and 19 messages mainly on the safety of health foods to disseminate appropriate knowledge to consumers. The report divided health food risks into three categories: 1) risks as food (e.g., increased lung cancer risk in smokers consuming excess β-carotenoid); 2) risks as health foods (e.g., short consumption history, drug contamination, poor quality of active ingredients, and inter...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Saito Y Tags: Yakugaku Zasshi Source Type: research

[Application of Lectin from Catfish Eggs to Cancer Therapy: A Fundamental Study].
Abstract Silurus asotus egg lectin (SAL) is an α-galactoside-binding protein, isolated from the egg of catfish. It belongs to the rhamnose-binding lectin family that binds to Gb3 glycan (Galα1-4Galβ1-4Glc). SAL has resulted in the induction of early apoptosis in the Raji cell line, which is a Burkitt's lymphoma cell line expressing Gb3. The apoptosis was characterized by i) increased externalization of phosphatidylserin via multidrug resistance 1 P-glycoprotein (MDR1 P-gp), and ii) reduced cell size through the activation of voltage-gated potassium channel Kv1.3. Although the incorporation of prop...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Sugawara S Tags: Yakugaku Zasshi Source Type: research

[Development of a Nano DDS for Cancer Immunotherapy Based on Llipid Nanoparticles].
Abstract The appearance of immune checkpoint inhibitors has been a major turning point in cancer therapy. The success of immune checkpoint therapy has revolutionized the field of cancer therapy, and immunotherapy has joined the cancer treatment ranks as a pillar. To induce effective anti-tumor immune responses, it is necessary both to enhance the activity of immune cells and to block immune suppression by tumor cells. Carrier type drug delivery systems based on nanobiotechnology (nano DDS) represent a potentially useful technology for efficiently achieving both: enhancement of the activity of immune cells and bloc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - December 8, 2018 Category: Drugs & Pharmacology Authors: Nakamura T Tags: Yakugaku Zasshi Source Type: research

Effects of Ramelteon and Other Sleep-Promoting Drugs on Serum Low-Density Lipoprotein and Non-high-density Lipoprotein Cholesterol: A Retrospective Comparative Pilot Study.
In this study effects of ramelteon on serum lipid profiles were explored, comparing to those of other sleep-promoting drugs including benzodiazepines and non-benzodiazepines, in patients with insomnia. We retrospectively reviewed medical charts of outpatients who were treated with ramelteon (8 mg/d) or other sleep-promoting drugs for no less than 8 weeks during the period between October 1st, 2011 and September 30th, 2014, and compared the changes in serum lipid profiles between the two groups. Patients with regular dialysis or malignant diseases treated with cytotoxic anti-cancer drugs, or whose lipid-lowering drug...
Source: Biological and Pharmaceutical Bulletin - December 8, 2018 Category: Drugs & Pharmacology Authors: Torii H, Shimizu R, Tanizaki Y, Omiya Y, Yamamoto M, Kamiike S, Yasuda D, Hiraoka Y, Hashida T, Kume N Tags: Biol Pharm Bull Source Type: research

Administration of High-Dose Vitamin C and Irinotecan Ameliorates Colorectal Cancer Induced by Azoxymethane and Dextran Sodium Sulfate in Mice.
In this study, we investigated the antitumor effect of high-dose vitamin C in a mouse model of chronic inflammation-associated colorectal cancer induced by azoxymethane (AOM) and dextran sodium sulfate (DSS). After cancer induction, the mice were administered vitamin C and/or irinotecan. Because irinotecan is a key drug in colorectal cancer treatment, it was used for comparison in this study. We examined reactive oxygen species (ROS) and interleukin-6 (IL-6) levels in the plasma of mice, as well as collagen type I and caspase-1 expression and neutrophil and terminal deoxynucleotidyl transferase-mediated deoxyuridine tripho...
Source: Biological and Pharmaceutical Bulletin - December 8, 2018 Category: Drugs & Pharmacology Authors: Kondo K, Sano R, Goto K, Hiramoto K, Ooi K Tags: Biol Pharm Bull Source Type: research

LY341495, an mGluR2/3 Antagonist, Regulates the Immunosuppressive Function of Myeloid-Derived Suppressor Cells and Inhibits Melanoma Tumor Growth.
In this study, we found that the metabotropic glutamate receptor (mGluR) 2/3 was expressed on MDSCs, and an mGluR2/3 antagonist LY341495 attenuated the immunosuppressive activity of MDSCs. Furthermore, we observed that LY341495 treatment inhibited B16-F10 melanoma growth in vivo. Taken together, our data suggest that glutamate signaling promotes tumor growth by increasing the potency of immune suppression. PMID: 30504687 [PubMed - in process] (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - December 8, 2018 Category: Drugs & Pharmacology Authors: Morikawa N, Tachibana M, Ago Y, Goda H, Sakurai F, Mizuguchi H Tags: Biol Pharm Bull Source Type: research

Enhancement of thermal imaging by iron oxide nanoparticle – preliminary study
Publication date: Available online 8 December 2018Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): S.P. Angeline Kirubha, Alankruti RajputAbstractMagnetic nanoparticles (MNP) have been developed in the recent years for various applications like cell separation, immunoassay, and drug delivery. The present study involves the synthesis of stable, biocompatible Iron oxide MNP by coprecipitation of ferric chloride and ferrous chloride with Polyethylene glycol (PEG) as a surfactant to coat the nanoparticles twice. Scanning electron microscopic (SEM) images confirm the formation of uniform MNPs of size 12–17&nb...
Source: Biocatalysis and Agricultural Biotechnology - December 8, 2018 Category: Biotechnology Source Type: research

Structural basis for renal cancer by the dynamics of pVHL-dependent JADE1 stabilization and β-catenin regulation
Publication date: Available online 7 December 2018Source: Progress in Biophysics and Molecular BiologyAuthor(s): Shagufta Shafique, Sajid RashidAbstractRenal cancer is the major cause of mortality due to abnormal functioning of von Hippel-Lindau (pVHL) and Jade Family PHD Finger 1 (JADE1) complex. E3 ubiquitin ligase JADE1 is stabilized by pVHL interaction through its plant homeodomains (PHDs). JADE1 acts as a renal tumor suppressor that promotes the ubiquitination and degradation of β-catenin by inhibiting canonical WNT signalling. Current study focuses on the structural characterization of reported missense mutation...
Source: Progress in Biophysics and Molecular Biology - December 8, 2018 Category: Molecular Biology Source Type: research

Metabolic syndrome and cancer risk: the role of xanthine oxidoreductase
Publication date: Available online 7 December 2018Source: Redox BiologyAuthor(s): Maria Giulia BATTELLI, Massimo BORTOLOTTI, Letizia POLITO, Andrea BOLOGNESIAbstractObesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders. XOR can play a role in the pathogenesis of both metabolic syndrome and cancer through the inflammatory response and the oxidative stress elicited by the products of its activity. The reactive oxygen and nitrogen species and the uric a...
Source: Redox Biology - December 8, 2018 Category: Biology Source Type: research

Redox-responsive Polymer Inhibits Macrophages Uptake for Effective Intracellular Gene Delivery and Enhanced Cancer Therapy
Publication date: Available online 7 December 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Lijuan Wen, Yingwen Hu, Tingting Meng, Yanan Tan, Mengdan Zhao, Suhuan Dai, Hong Yuan, Fuqiang HuAbstractThe development of advanced gene delivery carriers with stimuli-responsive release manner for tumor therapeutics is desirable, since they can exclusively release the therapeutic gene via their structural changes in response to the specific stimuli of the target site. Moreover, interactions between macrophages and drug delivery systems (DDSs) seriously impair the treatment efficiency of DDSs, thus macrophages uptake...
Source: Colloids and Surfaces B: Biointerfaces - December 8, 2018 Category: Biochemistry Source Type: research

Regioselective synthesis, structural diversification and cytotoxic activity of (thiazol-4-yl)furoxans
Publication date: November–December 2018Source: Mendeleev Communications, Volume 28, Issue 6Author(s): Alexander S. Kulikov, Margarita A. Epishina, Artem I. Churakov, Lada V. Anikina, Leonid L. Fershtat, Nina N. MakhovaThe effective and regioselective synthesis of new (2-hydrazinylthiazol-4-yl)furoxan hydrobromides based on the condensation of (bromoacetyl)furoxans with thiosemicarbazide has been developed. The cytotoxic activity of their derivatives (with hydrazone, 4-thiazolo[2.3-c][1,2,4]triazole or pyrrole moieties) against two human cancer cell lines (A549, HCT116) was tested and several structures revealed mode...
Source: Mendeleev Communications - December 8, 2018 Category: Chemistry Source Type: research

Pyrrolopyrrole Aza-BODIPY Near-infrared Photosensitizer for Dual-mode Imaging-Guided Photothermal Cancer Therapy
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC07768A, CommunicationXiao-Chen Dong, Chaolong Wu, Xiaoyu Huang, Yunyun Tang, Wanyue Xiao, Liguo Sun, Jinjun Shao A NIR photosensitizer pyrrolopyrrole Aza-BODIPY (PPAB) was straightforwardly synthesized. Using PPAB nanoparticles as photothermal agent, photothermal imaging and NIR fluorescence imaging can be achieved in vivo. And photothermal ablation of... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - December 8, 2018 Category: Chemistry Authors: Xiao-Chen Dong Source Type: research

Dibutyltin(IV) Complexes Derived from L-DOPA: Synthesis, Molecular Docking, Cytotoxic and Antifungal Activity.
eto-Camacho A, Gómez E Abstract A series of organotin(IV) complexes was herein prepared and characterized. A one-pot synthetic strategy afforded reasonable to high yields, depending on the nature of the ligand. All new complexes were fully characterized by spectroscopic techniques, consisting of IR, MS and NMR (1H, 13C and 119Sn). The in vitro cytotoxicity tests demonstrated that the organotin complexes produced a greater inhibition, versus cisplatin (the positive control), of the growth of six human cancer cell lines: U-251 (glioblastoma), K-562 (chronic myelogenous leukemia), HCT-15 (colorectal), MCF-7 (b...
Source: Chemical and Pharmaceutical Bulletin - December 8, 2018 Category: Drugs & Pharmacology Authors: Rocha-Del Castillo E, Gómez-García O, Andrade-Pavón D, Villa-Tanaca L, Ramírez-Apan T, Nieto-Camacho A, Gómez E Tags: Chem Pharm Bull (Tokyo) Source Type: research

The Long Noncoding RNA TTTY15, Which Is Located on the Y Chromosome, Promotes Prostate Cancer Progression by Sponging let-7
ConclusionsThe Y-chromosomal lncRNA TTTY15 was upregulated in most PCa tissues and could promote PCa progression by sponging let-7.Patient summaryWe found that TTTY15 levels were frequently elevated in prostate cancer (PCa) tissues compared with those in paracancerous normal tissues in a large group of PCa patients, and we observed a tumour suppressive effect after TTTY15 knockout using CRISPR/Cas9. These results may have therapeutic implications for PCa patients. (Source: European Urology)
Source: European Urology - December 8, 2018 Category: Urology & Nephrology Source Type: research

Homeobox B13 G84E Mutation and Prostate Cancer Risk
Publication date: Available online 8 December 2018Source: European UrologyAuthor(s): Tommy Nyberg, Koveela Govindasami, Goska Leslie, Tokhir Dadaev, Elizabeth Bancroft, Holly Ni Raghallaigh, Mark N. Brook, Nafisa Hussain, Diana Keating, Andrew Lee, Romayne McMahon, Angela Morgan, Andrea Mullen, Andrea Osborne, Reshma Rageevakumar, The UK Genetic Prostate Cancer Study Collaborators, Zsofia Kote-Jarai, Rosalind Eeles, Antonis C. AntoniouAbstractBackgroundThe homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutati...
Source: European Urology - December 8, 2018 Category: Urology & Nephrology Source Type: research