Marshalling the Potential of Auger Electron Radiopharmaceutical Therapy
Auger electron (AE) radiopharmaceutical therapy (RPT) may have the same therapeutic efficacy as α-particles for oncologic small disease, with lower risks of normal-tissue toxicity. The seeds of using AE emitters for RPT were planted several decades ago. Much knowledge has been gathered about the potency of the biologic effects caused by the intense shower of these low-energy AEs. Given their short range, AEs deposit much of their energy in the immediate vicinity of their site of decay. However, the promise of AE RPT has not yet been realized, with few agents evaluated in clinical trials and none becoming part of rout...
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Bolcaen, J., Gizawy, M. A., Terry, S. Y. A., Paulo, A., Cornelissen, B., Korde, A., Engle, J., Radchenko, V., Howell, R. W. Tags: Focus on Molecular Imaging Source Type: research
New Developments in Myeloma Treatment and Response Assessment
Recent innovative strategies have dramatically redefined the therapeutic landscape for treating multiple myeloma patients. In particular, the development and application of immunotherapy and high-dose therapy have demonstrated high response rates and have prolonged remission duration. Over the past decade, new morphologic or hybrid imaging techniques have gradually replaced conventional skeletal surveys. PET/CT using 18F-FDG is a powerful imaging tool for the workup at diagnosis and for therapeutic evaluation allowing medullary and extramedullary assessment. The independent negative prognostic value for progression-free an...
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Kraeber-Bodere, F., Jamet, B., Bezzi, D., Zamagni, E., Moreau, P., Nanni, C. Tags: Continuing Education Source Type: research
The Future of Nuclear Medicine
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Mankoff, D. Tags: Editor ' s Page Source Type: research
This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research
Reply: PSMA Is Not Specific to Prostate Cancer
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Notohamiprodjo, S., Eiber, M., Lohrmann, C., Weber, W. A. Tags: Letters Source Type: research
PSMA Is Not Specific to Prostate Cancer
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Ah-Thiane, L., Ferrer, L., Rousseau, C. Tags: Letters Source Type: research
Reply: Radiopharmaceutical Extravasations CanHave Consequences
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Parihar, A. S., Raymond-Schmidt, L., Crandall, J. P., Dehdashti, F., Wahl, R. L. Tags: Letters Source Type: research
Radiopharmaceutical Extravasations Can Have Consequences
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Bailey, D. L. Tags: Letters Source Type: research
161Tb-PSMA Radioligand Therapy: First-in-Humans SPECT/CT Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Al-Ibraheem, A., Doudeen, R. M., Juaidi, D., Abufara, A., Maus, S. Tags: Illustrated Post Source Type: research
Comparative Evaluation of [18F]5-Fluoroaminosuberic Acid and (4S)-4-3-[18F]fluoropropyl)-L-Glutamate as System Formula-Targeting Radiopharmaceuticals
Conclusion: [18F]FSPG had greater in vitro uptake than [18F]FASu in all cell lines tested; however, our results indicate that residual uptake differences exist between [18F]FSPG and [18F]FASu, suggesting alternative transporter activity in the cell lines tested. In vivo studies demonstrated the ability of both [18F]FASu and [18F]FSPG to image glioblastoma (U-87) and non–small cell lung cancer (A549) xenografts. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Colovic, M., Yang, H., Southcott, L., Merkens, H., Colpo, N., Benard, F., Schaffer, P. Tags: Basic Science Investigations Source Type: research
Endogenous Opioid Release After Orgasm in Man: A Combined PET/Functional MRI Study
Conclusion: Our data show that endogenous opioidergic activation in the medial temporal lobe is centrally involved in sexual arousal, and this circuit may be implicated in orgasmic disorders. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Jern, P., Chen, J., Tuisku, J., Saanijoki, T., Hirvonen, J., Lukkarinen, L., Manninen, S., Helin, S., Putkinen, V., Nummenmaa, L. Tags: Brief Communications Source Type: research
Facial Anonymization and Privacy Concerns in Total-Body PET/CT
Conclusion: We believe that the proposed method provides a baseline of anonymity and discretion when sharing image data online or between institutions and will help to facilitate collaboration and future regulatory compliance. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Selfridge, A. R., Spencer, B. A., Abdelhafez, Y. G., Nakagawa, K., Tupin, J. D., Badawi, R. D. Tags: Clinical Investigations Source Type: research
MIRD Pamphlet No. 28, Part 2: Comparative Evaluation of MIRDcalc Dosimetry Software Across a Compendium of Diagnostic Radiopharmaceuticals
Radiopharmaceutical dosimetry is usually estimated via organ-level MIRD schema-style formalisms, which form the computational basis for commonly used clinical and research dosimetry software. Recently, MIRDcalc internal dosimetry software was developed to provide a freely available organ-level dosimetry solution that incorporates up-to-date models of human anatomy, addresses uncertainty in radiopharmaceutical biokinetics and patient organ masses, and offers a 1-screen user interface as well as quality assurance tools. The present work describes the validation of MIRDcalc and, secondarily, provides a compendium of radiophar...
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Carter, L. M., Ocampo Ramos, J. C., Olguin, E. A., Brown, J. L., Lafontaine, D., Jokisch, D. W., Bolch, W. E., Kesner, A. L. Tags: Special Contributions Source Type: research
Importance of Blood Glucose Management Before 18F-FDG PET/CT in 322 Patients with Bacteremia of Unknown Origin
Conclusion: In patients with moderate to severe hyperglycemia, 18F-FDG PET/CT was much less likely to identify the focus of infection than in normoglycemic patients. Although current guidelines recommend postponing 18F-FDG PET/CT only in cases of severe hyperglycemia with glucose levels greater than 11 mmol/L (200 mg/dL), a lower blood glucose threshold seems to be more appropriate in patients with bacteremia of unknown origin and other infectious diseases. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Pijl, J. P., Glaudemans, A. W. J. M., Gheysens, O., Slart, R. H. J. A., Kwee, T. C. Tags: Clinical Investigations Source Type: research
Molecular Imaging of Myocardial Fibroblast Activation in Patients with Advanced Aortic Stenosis Before Transcatheter Aortic Valve Replacement: A Pilot Study
Conclusion: FAP-targeted PET identifies varying degrees of left ventricular fibroblast activation in TAVR candidates with advanced AS. 68Ga-FAPI signal does not match other imaging parameters, generating the hypothesis that it may become useful as a tool for personalized selection of optimal TAVR candidates. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Diekmann, J., Neuser, J., Rohrich, M., Derlin, T., Zwadlo, C., Koenig, T., Weiberg, D., Jackle, F., Kempf, T., Ross, T. L., Tillmanns, J., Thackeray, J. T., Widder, J., Haberkorn, U., Bauersachs, J., Bengel, F. M. Tags: FEATURED ARTICLE OF THE MONTH Source Type: research
