The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework
Conclusion: Refinements in this staging system are necessary to incorporate atypical variants and Braak-nonconformant cases. Further studies are needed to understand the possible applications of PET-based Braak staging to clinical practice and research. Furthermore, there is a need for standardization in the topographic definitions of Braak stage regions of interest to guarantee reproducibility and methodologic homogeneity across studies. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Macedo, A. C., Tissot, C., Therriault, J., Servaes, S., Wang, Y.-T., Fernandez-Arias, J., Rahmouni, N., Lussier, F. Z., Vermeiren, M., Bezgin, G., Vitali, P., Ng, K. P., Zimmer, E. R., Guiot, M.-C., Pascoal, T. A., Gauthier, S., Rosa-Neto, P. Tags: State of the Art Source Type: research
A Life Study in Academic Leadership: A Conversation Between Carolyn C. Meltzer and Hossein Jadvar
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Meltzer, C. C., Jadvar, H. Tags: Discussions with Leaders Source Type: research
This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research
Clinical Potential of HER2 PET as a Predictive Biomarker to Guide the Use of Trastuzumab Deruxtecan in Breast Cancer Patients
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Seban, R.-D., Champion, L., Bellesoeur, A., Vincent-Salomon, A., Bidard, F.-C. Tags: Letters Source Type: research
Incidental Detection of a Tenosynovial Giant Cell Tumor of the Thigh on [68Ga]Ga-FAPI PET/CT: Presentation of an Unusual Case
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Sellmann, T., Staak, F., Maurer, C., Rott, G., Witzke, O., Fendler, W., Schildhaus, H.-U., Podleska, L. E., Herrmann, K., Rischpler, C. Tags: Illustrated Post Source Type: research
High-Temporal-Resolution Lung Kinetic Modeling Using Total-Body Dynamic PET with Time-Delay and Dispersion Corrections
Conclusion: Corrections to the input function are important for accurate lung kinetic analysis of HTR dynamic PET data. The modeling of both delay and dispersion can improve model fitting and significantly impact quantification of $${K}_{1}$$, $${K}_{\hbox{ i }}$$, and $${v}_{\hbox{ b }}$$. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Wang, Y., Spencer, B. A., Schmall, J., Li, E., Badawi, R. D., Jones, T., Cherry, S. R., Wang, G. Tags: Clinical Investigations Source Type: research
Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies
Conclusion: FALCON allows fast and accurate correction of rigid and nonrigid WB motion artifacts while being insensitive to scanner hardware or tracer distribution, making it applicable to a wide range of PET imaging scenarios. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Shiyam Sundar, L. K., Lassen, M. L., Gutschmayer, S., Ferrara, D., Calabro, A., Yu, J., Kluge, K., Wang, Y., Nardo, L., Hasbak, P., Kjaer, A., Abdelhafez, Y. G., Wang, G., Cherry, S. R., Spencer, B. A., Badawi, R. D., Beyer, T., Muzik, O. Tags: Clinical Investigations Source Type: research
161Tb-DOTATOC Production Using a Fully Automated Disposable Cassette System: A First Step Toward the Introduction of 161Tb into the Clinic
Conclusion: The current study demonstrated that 161Tb has appropriate features for clinical use. The developed synthesis protocol guarantees high yields and safe preparation of injectable 161Tb-DOTATOC. The investigated approach could be translated to other DOTA-derivatized peptides; thus, 161Tb could be successfully applied in clinical practice for radionuclide therapy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Favaretto, C., Grundler, P. V., Talip, Z., Landolt, S., Sepini, L., Koster, U., Muller, C., Schibli, R., Geistlich, S., van der Meulen, N. P. Tags: Clinical Investigations Source Type: research
Optimized SPECT Imaging of 224Ra {alpha}-Particle Therapy by 212Pb Photon Emissions
Conclusion: SPECT/CT imaging of 224Ra in equilibrium with daughters is possible, with sufficient image quality to provide clinical utility for the current trial of intraperitoneally administrated activity. A systematic scheme for optimization was designed to select acquisition and reconstruction settings. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Mikalsen, L. T. G., Kvassheim, M., Stokke, C. Tags: Clinical Investigations Source Type: research
The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer
Conclusion: The variation in outcomes from RAI therapy of DTC may be explained, among other factors, by the range of absorbed doses delivered. The ability to assess the effect of treatments that modulate RAI uptake, and to estimate the absorbed doses at therapy, introduces the potential for patient stratification using a theranostic approach. Patient-specific absorbed dose planning might be the key to more successful treatment of advanced DTC. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Taprogge, J., Abreu, C., Yusuf, S., Ainsworth, G., Phillip, R. H., Gear, J. I., Gregory, R., Leek, F., Murray, I., Coulson, A. B., Brown, S. R., Du, Y., Newbold, K., Wadsley, J., Flux, G. D. Tags: Clinical Investigations Source Type: research
MIRD Pamphlet No. 28, Part 1: MIRDcalc--A Software Tool for Medical Internal Radiation Dosimetry
Medical internal radiation dosimetry constitutes a fundamental aspect of diagnosis, treatment, optimization, and safety in nuclear medicine. The MIRD committee of the Society of Nuclear Medicine and Medical Imaging developed a new computational tool to support organ-level and suborgan tissue dosimetry (MIRDcalc, version 1). Based on a standard Excel spreadsheet platform, MIRDcalc provides enhanced capabilities to facilitate radiopharmaceutical internal dosimetry. This new computational tool implements the well-established MIRD schema for internal dosimetry. The spreadsheet incorporates a significantly enhanced database com...
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Kesner, A. L., Carter, L. M., Ramos, J. C. O., Lafontaine, D., Olguin, E. A., Brown, J. L., President, B., Jokisch, D. W., Fisher, D. R., Bolch, W. E., SNMMI MIRD Committee Tags: Special Contributions Source Type: research
An International Study of Factors Affecting Variability of Dosimetry Calculations, Part 2: Overall Variabilities in Absorbed Dose
Conclusion: Variability in ADs was reduced as segmentation and time-integration data were provided to participants. Our results suggest that SPECT/CT-based imaging protocols generate more consistent and less variable results than planar imaging methods. Effort at standardizing segmentation and fitting should be made, as this may substantially reduce variability in ADs. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Brosch-Lenz, J., Ke, S., Wang, H., Frey, E., Dewaraja, Y. K., Sunderland, J., Uribe, C. Tags: Clinical Investigations Source Type: research
Voxel-Based Dosimetry Predicts Hepatotoxicity in Hepatocellular Carcinoma Patients Undergoing Radioembolization with 90Y Glass Microspheres
Conclusion: Voxel-based dosimetry may more accurately predict hepatotoxicity than multicompartment dosimetry in HCC patients undergoing radioembolization, which could enable dose escalation or deescalation with the intent to optimize treatment response. Our results indicate that a V40 of 72% may be particularly useful in whole-liver treatment. However, further research is warranted to validate these results. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Watanabe, M., Grafe, H., Theysohn, J., Schaarschmidt, B., Ludwig, J., Jochheim, L., Jeschke, M., Schmidt, H., Fendler, W. P., Moraitis, A., Herrmann, K., Pomykala, K. L., Weber, M. Tags: Clinical Investigations Source Type: research
Multicenter Evaluation of Frequency and Impact of Activity Infiltration in PET Imaging, Including Microscale Modeling of Skin-Absorbed Dose
Conclusion: When quantitative activity measurement criteria are used rather than visual, the frequency of PET infiltration appears substantially below frequencies previously published. Shallow doses to the epidermis from infiltration events are also likely substantially lower than previously reported because of absorption of β-particles in the dermis. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Sunderland, J. J., Graves, S. A., York, D. M., Mundt, C. A., Bartel, T. B. Tags: Clinical Investigations Source Type: research
Hybrid 18F-FET PET and Perfusion MRI to Differentiate Disease Progression from Treatment-Related Changes in Malignant Brain Tumors
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - June 30, 2023 Category: Nuclear Medicine Authors: Galldiks, N., Langen, K.-J. Tags: INVITED PERSPECTIVE Source Type: research
