Pioneering Research on Cancer Quality of Life and Outcomes: Johannes Czernin Discusses a Half-Century of Whole-Patient Focus with Patricia A. Ganz
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Authors: Ganz, P. A., Czernin, J. Tags: Discussions with Leaders Source Type: research
A Tribute to Our JNM Associate Editors
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Authors: Czernin, J. Tags: Editor ' s Page Source Type: research
This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - October 3, 2023 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research
Erratum
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Tags: Erratum Source Type: research
PSMA-Negative Lesion Progression Under 177Lu-PSMA Radioligand Therapy
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Murthy, V., Allen-Auerbach, M., Lam, R., Owen, D., Czernin, J., Calais, J. Tags: Illustrated Post Source Type: research
Preclinical Characterization of the Tau PET Tracer [18F]SNFT-1: Comparison of Tau PET Tracers
Conclusion: These preclinical data suggest that [18F]SNFT-1 is a promising and selective tau radiotracer candidate that allows the quantitative monitoring of age-related accumulation of tau aggregates in the human brain. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Harada, R., Lerdsirisuk, P., Shimizu, Y., Yokoyama, Y., Du, Y., Kudo, K., Ezura, M., Ishikawa, Y., Iwata, R., Shidahara, M., Ishiki, A., Kikuchi, A., Hatano, Y., Ishihara, T., Onodera, O., Iwasaki, Y., Yoshida, M., Taki, Y., Arai, H., Kudo, Y., Yanai, K., Tags: FEATURED BASIC SCIENCE ARTICLE Source Type: research
Multimodality Imaging of Aortic Valve Calcification and Function in a Murine Model of Calcific Aortic Valve Disease and Bicuspid Aortic Valve
Conclusion: 18F-NaF PET/CT links valvular calcification to BAV and aging in Dcbld2–/– mice and suggests that AS may promote calcification. In addition to addressing the pathobiology of valvular calcification, 18F-NaF PET/CT may be a valuable tool for evaluation of emerging therapeutic interventions in CAVD. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Ahmad, A. A., Ghim, M., Toczek, J., Neishabouri, A., Ojha, D., Zhang, Z., Gona, K., Raza, M. Z., Jung, J.-J., Kukreja, G., Zhang, J., Guerrera, N., Liu, C., Sadeghi, M. M. Tags: Basic Science Investigations Source Type: research
Temporal Changes in Coronary 18F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis
Conclusion: Coronary 18F-fluoride uptake is associated with the severity and progression of coronary artery disease but does not undergo a rapid dynamic change in patients with chronic or unstable coronary artery disease. This finding suggests that coronary 18F-fluoride uptake is a temporally stable marker of established and progressive disease. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Daghem, M., Adamson, P. D., Wang, K.-L., Doris, M., Bing, R., van Beek, E. J. R., Forsyth, L., Williams, M. C., Tzolos, E., Dey, D., Slomka, P. J., Dweck, M. R., Newby, D. E., Moss, A. J. Tags: Clinical Investigations Source Type: research
Monte Carlo Simulations Corroborate PET-Measured Discrepancies in Activity Assessments of Commercial 90Y Vials
Conclusion: The MC simulations performed in this study indicate that the discrepancies recently found between PET/CT-measured activity and vendor-calibrated activity for 90Y glass and resin microspheres can be attributed to differences in the geometry of the respective commercial vials and to the metrologic approach adopted for activity meter calibration with a 90Y-chloride liquid source. Furthermore, IB photons were shown to play a relevant role in determining the electric current in the activity meter. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Auditore, L., Pistone, D., Italiano, A., Amato, E., Gnesin, S. Tags: Clinical Investigations Source Type: research
Single-Time-Point Imaging for Dosimetry After [177Lu]Lu-DOTATATE: Accuracy of Existing Methods and Novel Data-Driven Models for Reducing Sensitivity to Time-Point Selection
Conclusion: The performance of the Madsen method and proposed data-driven models is less sensitive to TP selection than is the Hänscheid method. At the earliest TP, which is the most practical, the model incorporating baseline biomarkers outperforms other methods that rely only on the single activity measurement. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Wang, C., Peterson, A. B., Wong, K. K., Roseland, M. E., Schipper, M. J., Dewaraja, Y. K. Tags: Clinical Investigations Source Type: research
Specific Uptake in the Bone Marrow Causes High Absorbed Red Marrow Doses During [177Lu]Lu-DOTATATE Treatment
Conclusion: Our results suggest that specific red marrow uptake of [177Lu]Lu-DOTATATE is in line with observations of somatostatin receptor type 2–expressing hematopoietic progenitor cells within the bone marrow. Blood-based dosimetry methods fail to account for the prolonged elimination of specific uptake and underestimate the absorbed dose to red marrow. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Hemmingsson, J., Svensson, J., Hallqvist, A., Smits, K., Johanson, V., Bernhardt, P. Tags: Clinical Investigations Source Type: research
Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy
Conclusion: The satisfactory FAP-binding affinity and specificity, as well as the favorable in vivo pharmacokinetics of the FAPI tetramer, make it a promising radiopharmaceutical for theranostic applications. Improved tumor uptake and prolonged retention of the 177Lu-FAPI tetramer resulted in excellent characteristics for FAPI imaging and radioligand therapy. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Pang, Y., Zhao, L., Fang, J., Chen, J., Meng, L., Sun, L., Wu, H., Guo, Z., Lin, Q., Chen, H. Tags: Basic Science Investigations Source Type: research
Pretargeted Radioimmunotherapy of Ovarian Cancer with 225Ac and an Internalizing Antibody
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Li, X., Lan, X., Cai, W. Tags: INVITED PERSPECTIVE Source Type: research
Efficacy of HER2-Targeted Intraperitoneal 225Ac {alpha}-Pretargeted Radioimmunotherapy for Small-Volume Ovarian Peritoneal Carcinomatosis
Conclusion: Treatment of EOC PC-tumor–bearing mice with anti-HER2 225Ac-PRIT resulted in histologic cures and prolonged survival with minimal toxicity. Targeted α-therapy using the anti-HER2 225Ac-PRIT system is a potential treatment for otherwise incurable EOC. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Chung, S. K., Vargas, D. B., Chandler, C. S., Katugampola, S., Veach, D. R., McDevitt, M. R., Seo, S. H., Vaughn, B. A., Rinne, S. S., Punzalan, B., Patel, M., Xu, H., Guo, H.-F., Zanzonico, P. B., Monette, S., Yang, G., Ouerfelli, O., Nash, G. M., Cercek Tags: Basic Science Investigations Source Type: research
Dual-Time-Point Posttherapy 177Lu-PSMA-617 SPECT/CT Describes the Uptake Kinetics of mCRPC Lesions and Prognosticates Patients Outcome
Conclusion: The 177Lu-PSMA-617 clearance rate from mCRPC metastases appears to be a relevant prognosticator of response and survival, with faster clearing possibly signaling a shorter radiopharmaceutical residence time and absorbed dose. Dual-time-point analysis appears to be a feasible and readily available approach to estimate the likelihood of response and patients’ survival. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - September 1, 2023 Category: Nuclear Medicine Authors: Straub, M., Kupferschlager, J., Serna Higuita, L. M., Weissinger, M., Dittmann, H., la Fougere, C., Fiz, F. Tags: Clinical Investigations Source Type: research
