The Hierarchy of SUVs: From Diagnostics to Therapeutics and the Pathway to Effective Theranostics
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - December 1, 2023 Category: Nuclear Medicine Authors: Hofman, M. S. Tags: Editor ' s Page Source Type: research
A Strategic Approach to Advancing Nuclear Medicine and Molecular Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - December 1, 2023 Category: Nuclear Medicine Authors: Nadel, H. R. Tags: President ' s Message Source Type: research
This Month in JNM
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - December 1, 2023 Category: Nuclear Medicine Tags: This Month in JNM Source Type: research
Infection Imaging: Focus on New Tracers?
Infections account for relevant morbidity and mortality, especially if the cardiovascular system is affected. Clinical manifestations are often unspecific, resulting in a challenging diagnostic work-up. The use of molecular imaging methods, namely [18F]FDG PET and leukocyte scintigraphy, is increasingly recognized in recently published international guidelines. However, these 2 established methods focus on the host’s immune response to the pathogen and are therefore virtually unable to differentiate infection from inflammation. Targeting the microorganism responsible for the infection directly with novel imaging agen...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Roll, W., Faust, A., Hermann, S., Schafers, M. Tags: Clinical Investigations Source Type: research
Myocardial Fibrosis: Emerging Target for Cardiac Molecular Imaging and Opportunity for Image-Guided Therapy
Myocardial fibrosis is a major contributor to the development and progression of heart failure. Significant progress in the understanding of its pathobiology has led to the introduction and preclinical testing of multiple highly specific antifibrotic therapies. Because the mechanisms of fibrosis are highly dynamic, and because the involved cell populations are heterogeneous and plastic, there is increasing emphasis that any therapy directed specifically against myocardial fibrosis will require personalization and guidance by equally specific diagnostic testing for successful clinical translation. Noninvasive imaging techni...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Bengel, F. M., Diekmann, J., Hess, A., Jerosch-Herold, M. Tags: Basic Science Investigations Source Type: research
Imaging Inflammation Past, Present, and Future: Focus on Cardioimmunology
Growing evidence implicates the immune system as a critical mediator of cardiovascular disease progression and a viable therapeutic target. Increased inflammatory cell activity is seen in the full spectrum of disorders from early-stage atherosclerosis through myocardial infarction, cardiomyopathy, and chronic heart failure. Although therapeutic strategies to modulate inflammation have shown promise in preclinical animal models, efficacy in patients has been modest owing in part to the variable severity of inflammation across individuals. The diverse leukocyte subpopulations involved in different aspects of heart disease po...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Thackeray, J. T., Lavine, K. J., Liu, Y. Tags: Basic Science Investigations Source Type: research
Molecular Imaging Biomarkers in Cardiooncology: A View on Established Technologies and Future Perspectives
Novel therapeutic options have significantly improved survival and long-term outcomes in many cancer entities. Unfortunately, this improvement in outcome is often accompanied by new and increasingly relevant therapy-related cardiovascular toxicity. In this context, cardiooncology has emerged as a new field of interdisciplinary individual patient care. Important tasks are pretherapeutic risk stratification and early detection and treatment of cardiotoxicity, which comprises cardiac damage in relation to cardiovascular comorbidities, the tumor disease, and cancer treatment. Clinical manifestations can cover a broad spectrum,...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Kersting, D., Mavroeidi, I.-A., Settelmeier, S., Seifert, R., Schuler, M., Herrmann, K., Rassaf, T., Rischpler, C. Tags: Clinical Investigations Source Type: research
Molecular Imaging of Systemic and Cardiac Amyloidosis: Recent Advances and Focus on the Future
Myocardial infiltration by amyloid fibrils causes a severe and progressive form of heart failure. Until recently, this was not treatable. Several novel therapies have recently become available, increasing the urgency to make an accurate diagnosis, evaluate risk, and determine treatment response. Molecular imaging with positron-emitting amyloid tracers has a key emerging role in the evaluation and management of cardiac amyloidosis. In this review, we discuss molecular imaging of cardiac amyloidosis using amyloid PET tracers, including recent advances with a focus on the future. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Dorbala, S., Kijewski, M. F. Tags: Clinical Investigations Source Type: research
Quantitative Perfusion Imaging with Total-Body PET
Recently, PET systems with a long axial field of view have become the current state of the art. Total-body PET scanners enable unique possibilities for scientific research and clinical diagnostics, but this new technology also raises numerous challenges. A key advantage of total-body imaging is that having all the organs in the field of view allows studying biologic interaction of all organs simultaneously. One of the new, promising imaging techniques is total-body quantitative perfusion imaging. Currently, 15O-labeled water provides a feasible option for quantitation of tissue perfusion at the total-body level. This revie...
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Knuuti, J., Tuisku, J., Karpijoki, H., Iida, H., Maaniitty, T., Latva-Rasku, A., Oikonen, V., Nesterov, S. V., Teuho, J., Jaakkola, M. K., Klen, R., Louhi, H., Saunavaara, V., Nuutila, P., Saraste, A., Rinne, J., Nummenmaa, L. Tags: Clinical Investigations Source Type: research
Future of Radionuclide Myocardial Perfusion Imaging: Transitioning from SPECT to PET
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Di Carli, M. F. Tags: Clinical Investigations Source Type: research
The Evolution of Cardiac Nuclear Imaging
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Bengel, F. M., Di Carli, M. F. Tags: Clinical Investigations Source Type: research
Reply to: HER2-Low Breast Cancer Can Be Visualized by HER2 PET
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Seban, R.-D. Tags: Letters Source Type: research
HER2-Low Breast Cancer Can Be Visualized by HER2 PET
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Altena, R., af Buren, S., Tran, T., Axelsson, R. Tags: Letters Source Type: research
Obstructive Sialadenitis from Oral Squamous Cell Carcinoma: [68Ga]Ga-FAPI-46 PET-Positive and [18F]FDG PET-Negative
(Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Maliha, P. G., Mendelsohn, A. H., Czernin, J., Howard, T., Calais, J., Hotta, M. Tags: Illustrated Post Source Type: research
Total-Body Perfusion Imaging with [11C]-Butanol
Conclusion: This pilot study demonstrates the ability to obtain reproducible measurements of total-body perfusion using [11C]-butanol. The methods are sensitive to local perturbations in flow because of physiologic stressors and disease. (Source: Journal of Nuclear Medicine)
Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Li, E. J., Lopez, J. E., Spencer, B. A., Abdelhafez, Y., Badawi, R. D., Wang, G., Cherry, S. R. Tags: Clinical Investigations Source Type: research
