Comparative Evaluation of [18F]5-Fluoroaminosuberic Acid and (4S)-4-3-[18F]fluoropropyl)-L-Glutamate as System Formula-Targeting Radiopharmaceuticals

Conclusion: [18F]FSPG had greater in vitro uptake than [18F]FASu in all cell lines tested; however, our results indicate that residual uptake differences exist between [18F]FSPG and [18F]FASu, suggesting alternative transporter activity in the cell lines tested. In vivo studies demonstrated the ability of both [18F]FASu and [18F]FSPG to image glioblastoma (U-87) and non–small cell lung cancer (A549) xenografts.

Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Colovic, M., Yang, H., Southcott, L., Merkens, H., Colpo, N., Benard, F., Schaffer, P. Tags: Basic Science Investigations Source Type: research