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25% of high-grade glioma patients alive 3 years post trial
Patients with recurrent high-grade glioma were treated by the University of Minnesota Medical School. Median survival was 14.4 months, compared with the typical 8 months. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2017 Category: Consumer Health News Source Type: news

Onalespib could be an effective treatment for glioblastoma, preclinical studies show
This study showed that the targeted drug onalespib reduced the expression of cell-survival proteins such as AKT and endothelial growth factor receptor in glioma cell lines and glioma stem cells from patient tumors. This, in turn, reduced the survival, proliferation, invasion and migration of the cells. In animal models of glioblastoma the agent crossed the blood-brain barrier and showed effectiveness as a single agent and greater effectiveness in combination with temozolomide. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2017 Category: International Medicine & Public Health Source Type: news

25% of high-grade glioma patients live 3 years after trail
Patients with recurrent high-grade glioma were treated by the University of Minnesota Medical School. Median survival was 14.4 months, compared with the typical 8 months. (Source: the Mail online | Health)
Source: the Mail online | Health - November 1, 2017 Category: Consumer Health News Source Type: news

Gene Therapy May Fight Brain Cancer's Return
FRIDAY, Oct. 27, 2017 -- A new form of gene therapy shows promise in battling recurrent brain cancer. The phase 1 clinical trial included 56 patients with recurrent high-grade glioma brain cancer. Three years after the gene therapy treatment, more... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 27, 2017 Category: General Medicine Source Type: news

An experimental model might shed new light on the development of brain cancer in children
(DZNE - German Center for Neurodegenerative Diseases) Researchers of the German Center for Neurodegenerative Diseases (DZNE) present in the journal Cancer Cell a novel laboratory model that replicates key hallmarks of pediatric high-grade glioma. Results might pave the way for a better understanding of processes, relevant for both cancer and neurodegeneration. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 27, 2017 Category: International Medicine & Public Health Source Type: news

Cancer trial led by University of Minnesota Medical School's Dr. Clark Chen shows promise
(University of Minnesota Medical School) New data from a Phase I clinical trial led by Clark Chen, M.D., Ph.D., Lyle French Chair in Neurosurgery and Head of the University of Minnesota Medical School Department of Neurosurgery shows more than a quarter of patients with recurrent high-grade glioma, a form of brain cancer, were alive more than three years after treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 27, 2017 Category: Cancer & Oncology Source Type: news

Biology of childhood brain tumor subtypes offers clues to precision treatments
(Children's Hospital of Philadelphia) Researchers investigating pediatric low-grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer. By shedding light on subtle distinctions in tumor biology, these findings offer clues to designing more effective anticancer treatments to precisely target tumors in individual patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 16, 2017 Category: Cancer & Oncology Source Type: news

Areas of glioblastoma tumors correlate with separate subtypes of glioma stem cells
(University Hospitals Cleveland Medical Center) Study demonstrates, for the first time, that glioblastoma (GBM) is driven by two distinct subsets of cancer stem cells. Moreover, each subtype of glioma stem cells is driven by distinct transcriptional programs for growth and treatment resistance. The subsets also responded better to combination treatment in the mouse model. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 9, 2017 Category: Cancer & Oncology Source Type: news

Papers of note in Nature 549 (7673)
This week’s articles highlight the role of vitamin C in hematopoietic cells; a source of maternal inflammation that contributes to neurodevelopmental defects; the blocking of a niche factor that promotes the growth of gliomas; and a protein that influences DNA repair pathway choice. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - October 3, 2017 Category: Science Authors: VanHook, A. M. Tags: STKE Editors ' Choice Source Type: news

Brainlab wins FDA nod for Elements Spine, Cranial SRS radiosurgery planning software
Brainlab said today it won FDA clearance for its Elements Spine SRS and Elements Cranial SRS radiosurgery surgical planning software applications. The Munich, Germany-based company said that the Elements Cranial SRS is designed to allow physicians to create radiosurgery plans in less than 15 minutes, supporting plans for numerous cranial indications including arteriovenous malformations, pituitary adenoma, vestibular schwannoma, glioma, meningioma and large brain metastases. “We are highly impressed with the dosimetric results and the speed of plan optimization. We ran a few plan comparisons between our other plannin...
Source: Mass Device - September 21, 2017 Category: Medical Devices Authors: Fink Densford Tags: Food & Drug Administration (FDA) Radiosurgery Regulatory/Compliance Software / IT Brainlab Source Type: news

Stanford researchers halt brain cancer growth with absence of protein
Research at Stanford University suggests the growth of specific brain tumors -- high-grade gliomas -- can be stopped by cutting off access to a signaling molecule. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 21, 2017 Category: Consumer Health News Source Type: news

Researchers hit the brakes on lethal brain cancers in mice
(NIH/National Institute of Neurological Disorders and Stroke) New research conducted in mice provides evidence that highly lethal brain tumors, called high-grade gliomas, stop growing when deprived of a specific molecule naturally produced when brain cells fire. The experiments, led by a group of scientists from Stanford University, Palo Alto, California, suggest that targeting a protein called neuroligin-3 may prove beneficial in patients with these diseases. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 20, 2017 Category: Cancer & Oncology Source Type: news

New study shows that genomic profiling can help improve treatment of brain tumors in children
(Wiley) The largest genomic profiling study ever conducted into a type of brain tumor known as glioma in children has identified genetic alterations in 96% of cases. As reported in The Oncologist, this genetic information could help to identify the most effective treatments for specific cases of glioma, hopefully improving the prognosis for what is currently the leading cause of death for children with cancer in the US. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 14, 2017 Category: Cancer & Oncology Source Type: news

Zika virus may be useful in treating brain tumours
Conclusion This is an interesting piece of research that shows how knowledge in one field of medicine can sometimes be applied to another field with surprising results. But it's important to be realistic about the stage of research. This is very much a "proof of concept" study, and tests on cells, tissues and mice don't necessarily translate into a safe and effective treatment for humans. The study has several limitations, but the fact the treatment so far hasn't been tested on humans is the most important. For one thing, Zika virus doesn't naturally infect mice, so researchers had to use a specially engineered v...
Source: NHS News Feed - September 6, 2017 Category: Consumer Health News Tags: Cancer Source Type: news

New connections: Pleiotrophin and glioma
The cytokine pleiotrophin promotes the invasion and vascularization of glioma. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - September 5, 2017 Category: Science Authors: Wong, W. Tags: STKE Editors ' Choice Source Type: news

Oncolytic virotherapy offers new approach in treating brain tumors
For Jennifer Amsley and daughter Xia Martinez of Maryland, an oncolytic virotherapy study at Children ’s of Alabama has strengthened their resolve to fight and their desire for a sense of normalcy. Xia, 14, has an aggressive glioma brain tumor and an MRI showed new growth. That’s when doctors in Maryland informed Xia and her family of a clinical trial conducted by Dr. Gregory Friedman, associat e professor of pediatrics at the University of Alabama at Birmingham (UAB) and Children’s, and scientist… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 1, 2017 Category: Biotechnology Authors: Content provided by Children ’s of Alabama Source Type: news

Childhood Brain Stem Glioma Treatment
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - August 31, 2017 Category: General Medicine Source Type: news

Nanotech derived from amniotic stem cells could help treat brain cancer
Creative Medical Technology Holdings (OTC:CELZ) touted its exosome technology today, reporting that it demonstrated an ability to regenerate healthy brain cells while selectively halting the growth of glioma brain cancer cells in a preclinical model. The company’s exosomes are vesicles harvested from amniotic stem cell technology, which it licensed from the University of California San Diego in an exclusive deal for the AmnioStem platform. Get the full story at our sister site, Drug Delivery Business News. The post Nanotech derived from amniotic stem cells could help treat brain cancer appeared first o...
Source: Mass Device - July 26, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Neurological Oncology Research & Development Stent Grafts Wall Street Beat creativemedicaltechnologyholdings University of California at San Diego Source Type: news

Tocagen Receives European Medicines Agency Priority Medicines (PRIME) Designation for Toca 511 in High Grade Glioma
SAN DIEGO, July 24, 2017 -- (Healthcare Sales & Marketing Network) -- Tocagen Inc. (Nasdaq: TOCA), a clinical-stage, cancer-selective gene therapy company, today announced the European Medicines Agency (EMA) has granted Toca 511 (vocimagene amiretrorepvec... Biopharmaceuticals, Oncology, Regulatory Tocagen, Toca 511, glioma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - July 24, 2017 Category: Pharmaceuticals Source Type: news

Anti-cancer chemotherapeutic agent inhibits glioblastoma growth and radiation resistance
(University of Alabama at Birmingham) A collaborative team of neuro-oncology surgeon/scientists -- led by Ichiro Nakano, M.D., Ph.D., University of Alabama at Birmingham, and Maode Wang, M.D., Xi'an Jiaotong University, Xi'an, China -- has discovered a unique and previously unidentified molecular mechanism that maintains glioma stem cells, and they have tested it as a potential therapeutic target in glioblastoma, using a novel small molecule inhibitor they designed and synthesized (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 24, 2017 Category: Cancer & Oncology Source Type: news

Addy Sooter headed to Mexico for treatment for brain tumor
Addy Sooter, who lives in Rogers, Arkansas, was diagnosed with a diffuse intrinsic pontine glioma (DIPG) brain tumor in November 2016. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Girl headed to Mexico for at treatment for brain tumor
Addy Sooter, who lives in Rogers, Arkansas, was diagnosed with a diffuse intrinsic pontine glioma (DIPG) brain tumor in November 2016. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

FDA Approves Fluorescing Agent for Glioma Surgery
The US Food and Drug Administration has approved the optical imaging agent aminolevulinic acid hydrochloride to enhance visualization of malignant tissue during surgery for gliomas. (Source: CancerNetwork)
Source: CancerNetwork - June 28, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Brain Tumors News Source Type: news

Concussion researcher nets $25M for CTE program
Noted concussion researcher Dr. Julian Bailes has been awarded new grant...Read more on AuntMinnie.comRelated Reading: SNMMI: FET-PET could have answers for brainstem glioma SNMMI: PET can detect which plaques are at risk of rupture SNMMI partners with NDSC on appropriate use criteria SNMMI offers appropriate use criteria for 2 cancers SNMMI to Trump: Rescind travel ban (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 12, 2017 Category: Radiology Source Type: news

SNMMI: FET-PET could have answers for brainstem glioma
DENVER - Researchers in Switzerland are setting their sights on fluoroethyl-tyrosine...Read more on AuntMinnie.comRelated Reading: PET identifies cell mutations in NSCLC patients Novel PET tracer aids recurrent prostate cancer patients PET/CT CAD finds common spinal metastases PiB-PET could open window on common meningiomas ASTRO: PET predicts outcomes in vulvar cancer patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 12, 2017 Category: Radiology Source Type: news

Parents share video of their daughter's dying moments
Katie King, from California, died in June 2016 from Diffuse Intrinsic Pontic Glioma. Her mother Jaime has shared this video to make people understand the true horror of the hopeless disease. (Source: the Mail online | Health)
Source: the Mail online | Health - June 8, 2017 Category: Consumer Health News Source Type: news

FDA OKs Gleolan, First Fluorescing Agent for Glioma Surgery FDA OKs Gleolan, First Fluorescing Agent for Glioma Surgery
Gleolan oral solution (aminolevulinic acid hydrochloride) enhances the visualization of malignant tissue during glioma surgery.FDA Approvals (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 8, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

FDA Approves Gleolan (aminolevulinic acid hydrochloride) as an Optical Imaging Agent in Patients with Gliomas
June 6, 2017 - The U.S. Food and Drug Administration (FDA) has approved Gleolan [aminolevulinic acid hydrochloride (ALA HCl)] as an optical imaging agent indicated in patients with gliomas (suspected World Health Organization Grades III or IV on... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - June 6, 2017 Category: Drugs & Pharmacology Source Type: news

New target found to attack an incurable brain tumor in children
(Ann& Robert H. Lurie Children's Hospital of Chicago) Research shows that a tumor suppressor gene p16 is turned off by a histone mutation (H3.3K27M), which is found in up to 70 percent of childhood brain tumors called diffuse intrinsic pontine glioma (DIPG). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 6, 2017 Category: International Medicine & Public Health Source Type: news

Texas girl died five days after brain cancer diagnosis
Jade Bridier, from Bryan, Texas, was diagnosed with a rare brain tumor, called diffuse intrinsic pontine glioma (DIPG) in August. She died just five days after her diagnosis at four years old. (Source: the Mail online | Health)
Source: the Mail online | Health - May 30, 2017 Category: Consumer Health News Source Type: news

Northwestern Medicine initiates Phase I trial of stem cells + cold virus for glioma
US-based advanced healthcare solutions provider Northwestern Medicine has initiated the Phase I trial of a new neural stem-cell therapy in combination with a common cold virus to detect and destroy brain cancer in patients with malignant glioma. (Source: Drug Development Technology)
Source: Drug Development Technology - May 24, 2017 Category: Pharmaceuticals Source Type: news

Keeping up with Amanda: Life after brain surgery
In most ways, Amanda LePage is just like any other rambunctious fourth grader. She loves school, dance class, playing basketball and keeping up with her twin sister Macy and older brother Nathan. Sometimes it just takes her a little longer to do these everyday things. That’s because Amanda has been through a lot in her short nine years. Amanda was just 5 months old when she was brought by helicopter to Boston Children’s Hospital for a hemorrhage in her brain from an intracranial aneurysm, a type of vascular malformation. Despite long odds, Amanda survived two life-saving brain surgeries and a massive strok...
Source: Thrive, Children's Hospital Boston - May 22, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories brain aneurysm Dr. Caroline Robson Dr. Craig McClain Dr. Edward Smith Dr. Peter Manley Hydrocephalus low-grade glioma pediatric stroke Source Type: news

Texas boy, 7, dies after scan revealed rare brain tumor
Brock Fleming was diagnosed with diffuse intrinsic pontine glioma (DIPG) in May 2016. He he died in December at age seven due to the inoperable brain tumor. (Source: the Mail online | Health)
Source: the Mail online | Health - May 11, 2017 Category: Consumer Health News Source Type: news

Novel epigenetic changes in leukemia
Researchers have discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow. The mutations also play a role in a large majority of low-grade gliomas, which are among the most-treatable brain tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 10, 2017 Category: Science Source Type: news

Team uncovers novel epigenetic changes in leukemia
(University of Texas Health Science Center at San Antonio) UT Health San Antonio researchers discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow. The mutations also play a role in a large majority of low-grade gliomas, which are among the most-treatable brain tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 10, 2017 Category: Cancer & Oncology Source Type: news

NovoCure launches 2 pediatric trials of TTFields
NovoCure (NSDQ:NVCR) said today it is launching 2 pilot trials exploring the use of tumor treating fields to treat pediatric patients with high grade gliomas. The St. Helier, N.J.-based company produces the Optune, a mobile device that delivers low-intensity, intermediate frequency, alternating electric fields, referred to as “tumor treating fields” to inhibit cancer cell replication and cause cancer cell death. The 1st trial is being sponsored by the Pediatric Brain Tumor Consortium in collaboration with the National Cancer Institute and will study the feasibility of using TTFields on children w...
Source: Mass Device - May 4, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Clinical Trials Oncology NovoCure Source Type: news

Medical News Today: Brain cancer: Study sheds light on unexpected link between glioma and blood sugar
A new study begins to explain why glioma - a cancer that arises in the brain - is surprisingly less common in people with high blood sugar and diabetes. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 4, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Studies help shed light on aggressive brain cancer
Mutations affect how cancer starts in glial cells -- brain cells that provide support and insulation for neurons -- and how those mutations affect the way cancer evolves from low-grade gliomas to full-blown high-grade glioblastomas, the most common and deadly of primary brain cancer, shows a new study. A second study shows how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 3, 2017 Category: Science Source Type: news

Infographic: What are gliomas?
  Learn more about brain tumor/ gliamos. Other health tip infographics: mayohealthhighlights.startribune.com? (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 3, 2017 Category: Databases & Libraries Source Type: news

PET/CT helps predict therapy effectiveness in pediatric brain tumors
(Society of Nuclear Medicine) In this first ever molecular drug-imaging study in children, researchers in The Netherlands used whole-body positron emission tomography/computed tomography (PET/CT) scans to determine whether bevacizumab (Avastin) treatment of diffuse intrinsic pontine glioma (DIPG) in children is likely to be effective. The study is featured in the May 2017 issue of The Journal of Nuclear Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2017 Category: Global & Universal Source Type: news

TGen and UNC Lineberger studies help shed light on aggressive brain cancer
(The Translational Genomics Research Institute) One study showed that mutations affect how cancer starts in glial cells -- brain cells that provide support and insulation for neurons -- and how those mutations affect the way cancer evolves from low-grade gliomas to full-blown high-grade glioblastomas, the most common and deadly of primary brain cancer.The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2017 Category: Cancer & Oncology Source Type: news

Vaccines to Prevent High-Grade Glioma
This video examines current research on the use of vaccines in low-grade glioma for the prevention of high-grade disease. (Source: CancerNetwork)
Source: CancerNetwork - April 17, 2017 Category: Cancer & Oncology Authors: Hideho Okada, MD, PhD Tags: Conferences/AACR 2017 Brain Tumors Source Type: news

Early Promise with CMV-Targeted Vaccine for Glioma
(MedPage Today) -- Survival was more than double historical rates in small study (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 16, 2017 Category: Hematology Source Type: news

Antiparasitic drug may be new treatment for brain tumors
A new study shows that a common antiparasitic medication could be effective at treating certain brain cancers including low-grade glioma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 11, 2017 Category: Consumer Health News Source Type: news

Electronic Device Adds to Glioma Survival (CME/CE)
(MedPage Today) -- Tumor-treating fields device upped median survival (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 3, 2017 Category: Hematology Source Type: news

[Research Article] Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)–mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between IDH-mutant astrocytoma and oligodendroglioma can be primarily explained by distinct TME and signature genetic events, whereas both tumor types share similar developmental hierarchies and lineages of glial differentia...
Source: ScienceNOW - March 31, 2017 Category: Science Authors: Andrew S. Venteicher Source Type: news

Case comprehensive cancer center analyzes brain tumor data, doubles known risk factors for glioma
(Case Western Reserve University) A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 29, 2017 Category: Cancer & Oncology Source Type: news

Medical News Today: Large-scale study finds genetic errors associated with brain cancer
A new genomic study identifies 13 new genetic loci associated with an increased risk of glioma - the most common form of brain cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 28, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Scientists identify risk factors for glioma subtypes
A team of international researchers have identified genetic markers for two subtypes of glioma, an aggressive form of brain cancer. (Source: Health News - UPI.com)
Source: Health News - UPI.com - March 27, 2017 Category: Consumer Health News Source Type: news

New genetic risk factors identify two distinct glioma subtypes
An international consortium of researchers has conducted the largest study to date of malignant brain tumors looking for genetic markers of glioma, a highly aggressive form of brain cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 27, 2017 Category: Science Source Type: news