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Texas boy, 7, dies after scan revealed rare brain tumor
Brock Fleming was diagnosed with diffuse intrinsic pontine glioma (DIPG) in May 2016. He he died in December at age seven due to the inoperable brain tumor. (Source: the Mail online | Health)
Source: the Mail online | Health - May 11, 2017 Category: Consumer Health News Source Type: news

Novel epigenetic changes in leukemia
Researchers have discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow. The mutations also play a role in a large majority of low-grade gliomas, which are among the most-treatable brain tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 10, 2017 Category: Science Source Type: news

Team uncovers novel epigenetic changes in leukemia
(University of Texas Health Science Center at San Antonio) UT Health San Antonio researchers discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow. The mutations also play a role in a large majority of low-grade gliomas, which are among the most-treatable brain tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 10, 2017 Category: Cancer & Oncology Source Type: news

NovoCure launches 2 pediatric trials of TTFields
NovoCure (NSDQ:NVCR) said today it is launching 2 pilot trials exploring the use of tumor treating fields to treat pediatric patients with high grade gliomas. The St. Helier, N.J.-based company produces the Optune, a mobile device that delivers low-intensity, intermediate frequency, alternating electric fields, referred to as “tumor treating fields” to inhibit cancer cell replication and cause cancer cell death. The 1st trial is being sponsored by the Pediatric Brain Tumor Consortium in collaboration with the National Cancer Institute and will study the feasibility of using TTFields on children w...
Source: Mass Device - May 4, 2017 Category: Medical Equipment Authors: Fink Densford Tags: Clinical Trials Oncology NovoCure Source Type: news

Medical News Today: Brain cancer: Study sheds light on unexpected link between glioma and blood sugar
A new study begins to explain why glioma - a cancer that arises in the brain - is surprisingly less common in people with high blood sugar and diabetes. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 4, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Studies help shed light on aggressive brain cancer
Mutations affect how cancer starts in glial cells -- brain cells that provide support and insulation for neurons -- and how those mutations affect the way cancer evolves from low-grade gliomas to full-blown high-grade glioblastomas, the most common and deadly of primary brain cancer, shows a new study. A second study shows how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 3, 2017 Category: Science Source Type: news

Infographic: What are gliomas?
  Learn more about brain tumor/ gliamos. Other health tip infographics: mayohealthhighlights.startribune.com? (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 3, 2017 Category: Databases & Libraries Source Type: news

PET/CT helps predict therapy effectiveness in pediatric brain tumors
(Society of Nuclear Medicine) In this first ever molecular drug-imaging study in children, researchers in The Netherlands used whole-body positron emission tomography/computed tomography (PET/CT) scans to determine whether bevacizumab (Avastin) treatment of diffuse intrinsic pontine glioma (DIPG) in children is likely to be effective. The study is featured in the May 2017 issue of The Journal of Nuclear Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 2, 2017 Category: Global & Universal Source Type: news

TGen and UNC Lineberger studies help shed light on aggressive brain cancer
(The Translational Genomics Research Institute) One study showed that mutations affect how cancer starts in glial cells -- brain cells that provide support and insulation for neurons -- and how those mutations affect the way cancer evolves from low-grade gliomas to full-blown high-grade glioblastomas, the most common and deadly of primary brain cancer.The other study showed how using a combination of drugs at increased potency could prove an effective therapy against glioblastoma by inhibiting the PI3K and MAPK cellular pathways. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 2, 2017 Category: Cancer & Oncology Source Type: news

Vaccines to Prevent High-Grade Glioma
This video examines current research on the use of vaccines in low-grade glioma for the prevention of high-grade disease. (Source: CancerNetwork)
Source: CancerNetwork - April 17, 2017 Category: Cancer & Oncology Authors: Hideho Okada, MD, PhD Tags: Conferences/AACR 2017 Brain Tumors Source Type: news

Early Promise with CMV-Targeted Vaccine for Glioma
(MedPage Today) -- Survival was more than double historical rates in small study (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 16, 2017 Category: Hematology Source Type: news

Antiparasitic drug may be new treatment for brain tumors
A new study shows that a common antiparasitic medication could be effective at treating certain brain cancers including low-grade glioma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 11, 2017 Category: Consumer Health News Source Type: news

Electronic Device Adds to Glioma Survival (CME/CE)
(MedPage Today) -- Tumor-treating fields device upped median survival (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - April 3, 2017 Category: Hematology Source Type: news

[Research Article] Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these influences in isocitrate dehydrogenase (IDH)–mutant gliomas by combining 14,226 single-cell RNA sequencing (RNA-seq) profiles from 16 patient samples with bulk RNA-seq profiles from 165 patient samples. Differences in bulk profiles between IDH-mutant astrocytoma and oligodendroglioma can be primarily explained by distinct TME and signature genetic events, whereas both tumor types share similar developmental hierarchies and lineages of glial differentia...
Source: ScienceNOW - March 31, 2017 Category: Science Authors: Andrew S. Venteicher Source Type: news

Case comprehensive cancer center analyzes brain tumor data, doubles known risk factors for glioma
(Case Western Reserve University) A massive new study involving blood samples from over 30,000 individuals has identified 13 new genetic risk factors for glioma, the most common type of malignant brain tumor in adults. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 29, 2017 Category: Cancer & Oncology Source Type: news

Medical News Today: Large-scale study finds genetic errors associated with brain cancer
A new genomic study identifies 13 new genetic loci associated with an increased risk of glioma - the most common form of brain cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 28, 2017 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Scientists identify risk factors for glioma subtypes
A team of international researchers have identified genetic markers for two subtypes of glioma, an aggressive form of brain cancer. (Source: Health News - UPI.com)
Source: Health News - UPI.com - March 27, 2017 Category: Consumer Health News Source Type: news

New genetic risk factors identify two distinct glioma subtypes
An international consortium of researchers has conducted the largest study to date of malignant brain tumors looking for genetic markers of glioma, a highly aggressive form of brain cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 27, 2017 Category: Science Source Type: news

New genetic risk factors identify 2 distinct glioma subtypes
(Baylor College of Medicine) An international consortium of researchers led by Dr. Melissa Bondy, professor of medicine at Baylor College of Medicine, has conducted the largest study to date of malignant brain tumors looking for genetic markers of glioma, a highly aggressive form of brain cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 27, 2017 Category: Global & Universal Source Type: news

Genetic mutations help brain tumors evade targeting by immunotherapy treatments
(JCI Journals) In a study published this week in the JCI, Hideho Okada's lab at UCSF investigated whether acquired mutations in the enzyme isocitrate dehydrogenase (IDH), which are common in low-grade gliomas, help these tumors become resistant to immunotherapy. In both human astrocytes and mouse models of glioma, the IDH mutations impaired immune responses in the tumor environment by reducing the recruitment of T cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 20, 2017 Category: Cancer & Oncology Source Type: news

Promising new strategy to attack the most lethal brain tumor in children
Researchers have revealed new insight into how the most deadly pediatric brain tumor, diffuse intrinsic pontine glioma (DIPG), may develop. They also have identified a compound that targets the " on " switch for cancer-promoting genes, which resulted in shrinking tumor size and increased survival in an animal model of DIPG. Preparations for a clinical trial are now under way. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 7, 2017 Category: Science Source Type: news

Molecule stops fatal pediatric brain tumor
The scientists have found a molecule that stops the growth of an aggressive pediatric brain tumor. The tumor is always fatal and primarily strikes children under 10 years old. Every year, about 300 children under the age of 10 years old in the U.S. develop a tumor referred to as diffuse intrinsic pontine glioma (DIPG). (Source: World Pharma News)
Source: World Pharma News - February 28, 2017 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Study shows molecule may stop pediatric brain tumor
Researchers at Northwestern University have found a molecule that can kill an aggressive pediatric brain tumor called diffuse intrinsic pontine glioma, or DIPG. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 27, 2017 Category: Consumer Health News Source Type: news

Make the Diagnosis: Cerebrospinal Fluid Color Challenge
(MedPage Today) -- Case Findings: A 3-year-old boy with a brain stem glioma develops hydrocephalus and is treated with a ventriculoperitoneal shunt. He presents with green cerebrospinal fluid. What is your diagnosis? (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 19, 2016 Category: American Health Source Type: news

Attractive drug candidate identified to target glioma brain tumors
(University of Alabama at Birmingham) In a paper published in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed. The inhibitor, GA11, retains a core structure that resembles natural inhibitors of the biomarker enzyme; but it has been modified to help it pass through the blood-brain barrier. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 15, 2016 Category: Cancer & Oncology Source Type: news

The antibody that normalizes tumor vessels
Scientists have discovered that their antisepsis antibody also reduces glioma, lung and breast cancer progression in mice, outlines a new report. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 12, 2016 Category: Science Source Type: news

The antibody that normalizes tumor vessels
(Institute for Basic Science) IBS scientists discover that their antisepsis antibody also reduces glioma, lung and breast cancer progression in mice. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 12, 2016 Category: Cancer & Oncology Source Type: news

Medical News Today: Brain cancer: New biomarker could improve diagnosis of glioma
After analyzing data from many genetic studies, researchers find that a high expression of SHOX2 gene predicts poor survival in intermediate-grade gliomas. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - December 7, 2016 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Researchers find new biomarker for brain cancer prognosis
(UT Southwestern Medical Center) Researchers at UT Southwestern Medical Center have found a new biomarker for glioma, a common type of brain cancer, that can help doctors determine how aggressive a cancer is and that could eventually help determine the best course of treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 6, 2016 Category: Cancer & Oncology Source Type: news

IDH1 Mutations Might Underlie Glioma-Associated Epilepsy
IDH1-mutant gliomas can affect adjacent, nonmalignant cells in ways that trigger seizures, according to research reported at the 21st Annual Scientific Meeting of the Society for Neuro-Oncology. (Source: CancerNetwork)
Source: CancerNetwork - November 22, 2016 Category: Cancer & Oncology Authors: Bryant Furlow Tags: Brain Tumors Conference Report Conferences/SNO 2016 Source Type: news

Cell of origin in childhood brain tumors affects susceptibility to therapy
Children that are diagnosed with the severe the brain tumor malignant glioma often have a very poor prognosis. Knowledge about how pediatric malignant glioma arises and develops is still limited. New findings show that in mice glioma development and glioma cell properties are affected by both age and the cell type from which the tumor has arisen. The tumor cell of origin was also important for the susceptibility of the tumor cells towards cancer drugs. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 17, 2016 Category: Science Source Type: news

Glioma-Associated Fatigue and Cognitive Dysfunction
As part of our coverage of the 21st Annual Scientific Meeting of the Society for Neuro-Oncology, we discuss fatigue and cognitive dysfunction in patients with glioma. (Source: CancerNetwork)
Source: CancerNetwork - November 17, 2016 Category: Cancer & Oncology Authors: David Cachia, MD, MRCP Tags: Brain Tumors Q & Conferences/SNO 2016 Source Type: news

The cell of origin in childhood brain tumors affects susceptibility to therapy
(Uppsala University) Children that are diagnosed with the severe the brain tumor malignant glioma often have a very poor prognosis. New findings from Uppsala University show that in mice glioma development and glioma cell properties are affected by both age and the cell type from which the tumor has arisen. The tumor cell of origin was also important for the susceptibility of the tumor cells towards cancer drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 17, 2016 Category: Cancer & Oncology Source Type: news

Superheroes, super kids in super costumes don ’t let cancer stop Halloween
Children from the Jimmy Fund Clinic and their families trick or treat through Dana Farber. Photo courtesy of Sydney Altschuler. Abby Roxo likes to be unique on Halloween, and today she had unique totally covered. The 9-year-old from Shrewsbury, Massachusetts, arrived at the outpatient clinic of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center ready for the annual Halloween parade. Wearing a feathery white halo, white shirt and white pants with large black spots, Abby, who made her costume with the help of her sisters, also drew black spots on her cheeks and wore brigh...
Source: Thrive, Children's Hospital Boston - October 31, 2016 Category: Pediatrics Authors: Irene Sege Tags: Our Patients’ Stories Dana-Farber/Boston Children's Cancer and Blood Disorders Center Halloween leukemia low-grade glioma Source Type: news

New device enables rapid identification of brain cancer type and tumor margin
(Nagoya University) Researchers centered at Nagoya University developed a device for rapidly determining whether a brain sample is positive for a mutation commonly associated with glioma, a type of brain cancer with poor prognosis. This device is accurate and quick to use, enabling diagnosis of tumor type and determination of tumor margins during an operation. This breakthrough should improve decision-making by surgeons and ultimately help reduce glioma-related mortality. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 4, 2016 Category: Cancer & Oncology Source Type: news

IDH and CIC mutations provide prognostic information for grade II and III gliomas
(NRG Oncology) NRG Oncology investigators have identified two biomarkers that are prognostic of overall and progression-free survival for patients with lower-grade gliomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 3, 2016 Category: Cancer & Oncology Source Type: news

These Parents Want You To Get 'Mad As Hell' About Pediatric Cancer
Like most 4-year-olds, Phoebe Dooley loves toys, animals and stories. She has a wild imagination, a great sense of humor and a wisdom beyond her years. Her favorite color is pink. Unlike most 4-year-olds, Phoebe is battling an aggressive brain cancer that is notoriously difficult to treat. With the help of an altruistic photographer, Phoebe’s parents want to shine a light on their daughter’s story and encourage people to donate to cancer research. On March 22, 2016, Phoebe was diagnosed with diffuse intrinsic pontine glioma (DIPG), a brain tumor that affects approximately 300 children in the U.S. eac...
Source: Science - The Huffington Post - September 29, 2016 Category: Science Source Type: news

These Parents Want You To Get 'Mad As Hell' About Pediatric Cancer
Like most 4-year-olds, Phoebe Dooley loves toys, animals and stories. She has a wild imagination, a great sense of humor and a wisdom beyond her years. Her favorite color is pink. Unlike most 4-year-olds, Phoebe is battling an aggressive brain cancer that is notoriously difficult to treat. With the help of an altruistic photographer, Phoebe’s parents want to shine a light on their daughter’s story and encourage people to donate to cancer research. On March 22, 2016, Phoebe was diagnosed with diffuse intrinsic pontine glioma (DIPG), a brain tumor that affects approximately 300 children in the U.S. eac...
Source: Healthy Living - The Huffington Post - September 29, 2016 Category: Consumer Health News Source Type: news

DelMar, Accurexa ink deal for chemotherapy combo
DelMar Pharmaceuticals and Accurexa  said today that they inked a deal to collaborate on a combination chemotherapy for local treatment of brain cancer. The agreement calls for DelMar to supply the drug dianhydrogalactitol (VAL-083) as part of a combination with another chemotherapeutic, either temozolomide or carmustine, for local delivery to the tumor via Accurexa’s ACX-31 implantable polymer wafer. DelMar said its drug proved successful in more than 40 clinical trials sponsored by the U.S. National Cancer Institute, winning orphan drug designation as a treatment for gliomas, medulloblastoma and ovarian c...
Source: Mass Device - September 7, 2016 Category: Medical Equipment Authors: Sarah Faulkner Tags: Drug-Device Combinations Neurological Oncology Pharmaceuticals Research & Development Accurexa Inc. DelMar Pharmaceuticals Source Type: news

Vinblastine First-Line Option for Pediatric Low-Grade Glioma
Vinblastine monotherapy produced outcomes similar to current therapies in children with treatment-naive pediatric low-grade glioma, and had favorable toxicity and quality-of-life profiles. (Source: CancerNetwork)
Source: CancerNetwork - September 3, 2016 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Brain Tumors News Source Type: news

Cancer spreading: Caught in the act
Scientists at the California NanoSystems Institute at UCLA have taken a major step toward confirming an unusual theory of how some cancer cells metastasize. Their findings may lead to new strategies for keeping melanoma from spreading.  A commonly held theory about how cancer spreads is that tumor cells break off from the primary tumor and travel through the bloodstream to reach other organs, where they attach and grow into new tumors. But questions about that process have remained because circulating tumor cells in the blood sometimes have a short lifespan, and because of a lack of knowledge about how the cells leave...
Source: UCLA Newsroom: Health Sciences - August 15, 2016 Category: Universities & Medical Training Source Type: news

Low oxygen, high risk: How tumors adapt to become more aggressive
Scientists have identified a novel mechanism that selectively operates in hypoxic tumors to enable tumor cells to thrive and continue to proliferate despite a low oxygen environment. The research team showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas – a type of brain tumor – and how the pathway could be a valuable therapeutic target in cancer. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 8, 2016 Category: Science Source Type: news

Low oxygen, high risk: How tumors adapt to become more aggressive
(The Wistar Institute) Wistar scientists have identified a novel mechanism that selectively operates in hypoxic tumors to enable tumor cells to thrive and continue to proliferate despite a low oxygen environment. Dario C. Altieri, M.D., Wistar's President and CEO and lead author of the study, and colleagues showed how the activation of this pathway leads to an unfavorable prognosis for patients with gliomas -- a type of brain tumor -- and how the pathway could be a valuable therapeutic target in cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 8, 2016 Category: Cancer & Oncology Source Type: news

Calgary girl passes torch to family after dying from brain tumour
Bill Gould said his daughter’s cancer specialist offered some words of wisdom when Natasha was diagnosed with diffuse intrinsic pontine glioma (DIPG) cancer in May of 2015. (Source: CBC | Health)
Source: CBC | Health - August 7, 2016 Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news

Calgary girl passes torch to family before dying from brain tumour
Bill Gould said his daughter’s cancer specialist offered some words of wisdom when Natasha was diagnosed with diffuse intrinsic pontine glioma (DIPG) cancer in May of 2015. (Source: CBC | Health)
Source: CBC | Health - August 7, 2016 Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news

Researchers may have found an 'antidepressant roadblock'
Conclusion This experimental study in rat brain cells investigated the delay in the action of antidepressants. This research hopes to aid the development of faster-acting treatments in the future. It is thought antidepressants work by increasing levels of neurotransmitters, such as serotonin, in the brain – chemicals that can improve mood and emotion. The researchers' experiments in rats found antidepressants seem to lead to a gradual redistribution of Gα proteins to the lipid membrane of the brain cells, which in turn affects signalling processes. However, this is a slow process that seems to depend on t...
Source: NHS News Feed - August 1, 2016 Category: Consumer Health News Tags: Mental health Medication Neurology Source Type: news

Radiotherapy for diffuse brainstem glioma in children and young adults
The authors conclude that they could make no definitive conclusions from this review based on the currently available evidence. Further research is needed to establish the role of radiotherapy in the management of newly diagnosed diffuse brainstem glioma in children and young adults. Future RCTs should be conducted with adequate power and all relevant outcomes should be taken into consideration. Moreover, international multicentre collaboration is encouraged. Considering the potential advantage of hypofractionated radiotherapy to decrease the treatment burden and increase the quality of remaining life, we suggest that more...
Source: Current Awareness Service for Health (CASH) - July 27, 2016 Category: Consumer Health News Source Type: news

Targeting Fatty Acid Oxidation Might Quell Brain Cancer CellsTargeting Fatty Acid Oxidation Might Quell Brain Cancer Cells
In vitro and murine studies suggest that inhibition of fatty acid oxidation could help disrupt metabolic processes in glioma cells, according to UK investigators. Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - July 15, 2016 Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news

Having A College Education Linked To This Serious Health Risk
People with higher levels of education may be more likely to develop certain types of brain tumors, a new study from Sweden suggests. Researchers found that women who completed at least three years of university courses were 23 percent more likely to develop a type of cancerous brain tumor called glioma, compared with women who only completed up to nine years of mandatory education and did not go to a university. And men who completed at least three years of university courses were 19 percent more likely to develop the same type of tumor, compared with men who did not go to a university. Though the reasons behind the link ...
Source: Healthy Living - The Huffington Post - June 23, 2016 Category: Consumer Health News Source Type: news

Medical News Today: Brain tumor risk linked to high education level
A new population-wide study shows gliomas are more common among people who studied at university for 3 years, compared with those who did not. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - June 21, 2016 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news