Targeted drug combination shows unprecedented activity in some highly aggressive brain tumors
A combination of two targeted cancer drugs showed unprecedented, "clinically meaningful" activity in patients with highly malignant brain tumors that carried a rare genetic mutation, according to a clinical trial report by investigators from Dana-Farber Cancer Institute. The drug combination, which blocked an overactive cell-growth signaling pathway, shrank tumors by 50% or more in one-third of 45 patients with hard-to-treat high-grade gliomas, including glioblastomas, the most aggressive brain tumor. (Source: World Pharma News)
Source: World Pharma News - November 25, 2021 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Alpheus Medical Closes $16M In Series A Financing For Novel Glioma Brain Cancer Treatment
Funds to support first-in-human (FIH) clinical trial of the company's proprietary, non-invasive sonodynamic drug-device therapy system for recurrent high-grade gliomas OAKDALE, Minn., Nov. 17, 2021 -- (Healthcare Sales & Marketing Network) -- Alpheus™ ... Devices, Oncology, Venture Capital Alpheus Medical, sonodynamic therapy, glioblastoma multiforme (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 17, 2021 Category: Pharmaceuticals Source Type: news

Dual-drug treatment offers hope to children with rare brain cancer
Scientists make ‘promising’ breakthrough on fast-growing DIPG type of tumourScientists have successfully combined two existing cancer drugs to create a treatment for children diagnosed with deadly brain tumours.Diffuse intrinsic pontine glioma (DIPG), a rare and fast-growing type of brain tumour in children, can mutate and evolve to resist treatment with a single drug. There is currently no cure and many children found to have the disease die within months.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - November 5, 2021 Category: Science Authors: Andrew Gregory Health editor Tags: Medical research Cancer Children's health UK news Science Source Type: news

Novel Virus Targeting Deadly Brain Tumors Shows Early Promise Novel Virus Targeting Deadly Brain Tumors Shows Early Promise
Early evidence suggests that an oncolytic virus engineered to kill malignant gliomas may improve survival.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 22, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Upstate Foundation awards $50,000 for brain cancer research
Funding supports research program to develop novel treatments for patients with malignant gliomas, the most aggressive form of brain cancer (Source: SUNY Upstate Medical)
Source: SUNY Upstate Medical - September 1, 2021 Category: Universities & Medical Training Tags: News Source Type: news

The promoting effect of traumatic brain injury on the incidence and progression of glioma: a review of clinical and experimental research - Lan YL, Zhu Y, Chen G, Zhang J.
The role of traumatic brain injury in the development of glioma is highly controversial since first presented. This is not unexpected because traumatic brain injuries are overwhelmingly more common than glioma. However, the causes of post-traumatic glioma ... (Source: SafetyLit)
Source: SafetyLit - August 13, 2021 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

MRI, histopathologic features boost glioma survival prediction accuracy
Combining MRI and digital histopathologic imaging features boosts the accurac...Read more on AuntMinnie.comRelated Reading: AI can identify sarcopenia in glioblastoma patients Structured reporting enhances brain tumor MRI How cost-effective is intraoperative MRI for gliomas? Gadolinium in gliomas, adjacent tissue raises questions Blue Earth study reports Axumin can aid glioma diagnosis (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 27, 2021 Category: Radiology Source Type: news

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas
(Impact Journals LLC) This Oncotarget study confirms the upregulation of TERT in primary glioblastomas while all GABP proteins rise with the malignancy of the gliomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 26, 2021 Category: Cancer & Oncology Source Type: news

Geneticists reveal how mutation causes childhood cancer; use drug to reverse its effects
(Trinity College Dublin) Geneticists from Trinity College Dublin have discovered how a specific genetic mutation (H3K27M) causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and - in lab studies working with model cell types - successfully reverse its effects to slow cancer cell growth with a targeted drug. Their landmark work - just published in leading international journal, Nature Genetics - translates crucial new understanding of the genetics of DMG progression into a highly promising, targeted therapeutic approach and offers significant hope of improved treatments in the future. (S...
Source: EurekAlert! - Cancer - July 22, 2021 Category: Cancer & Oncology Source Type: news

Consumer Health: Understanding glioblastoma
Glioblastoma Awareness Day will be observed on Wednesday, July 21, which makes this a good time to learn more about one of the most complex, deadly and treatment-resistant cancers. Glioblastoma, a type of glioma, is an aggressive cancer that can occur in the brain or spinal cord. It can occur at any age, but it tends to occur more often in older adults. Approximately 13,000 people in the U.S. will be diagnosed with glioblastoma in… (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 21, 2021 Category: Databases & Libraries Source Type: news

Sleeper cells: Newly discovered stem cell resting phase could put brain tumors to sleep
(Arizona State University) Arizona State University biomedical engineering researchers developed a new cell classifier tool that takes a higher-resolution look at the life cycle of neuroepithelial stem cells, which led to the discovery and exploration of a new resting phase called Neural G0. This knowledge could help scientists to better understand glioma brain tumors and develop new methods of treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 25, 2021 Category: International Medicine & Public Health Source Type: news

MRI shows gadolinium-based contrast elimination is greater after sleep
Brain MRI shows that gadolinium-based contrast clears from patients' glymphati...Read more on AuntMinnie.comRelated Reading: Macrocyclic gadolinium contrast not to blame for brain deposits DTI-MRI shows effects of anesthesia on brain's white matter Gadolinium breast MRI screening OK for healthy women Gadolinium in gliomas, adjacent tissue raises questions MRI shows side sleeping may prevent neurological disease (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - June 23, 2021 Category: Radiology Source Type: news

' Remarkable' Results for Targeted Therapy of Rare CNS Tumors'Remarkable' Results for Targeted Therapy of Rare CNS Tumors
The results come from three small studies of targeted therapy for papillary craniopharyngiomas (PCPs), gliomas and neuroblastomas.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - June 16, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

POT1 gene mutation predisposes to glioma and affects survival in a sex-specific manner
(Baylor College of Medicine) Researchers have discovered that POT1, a gene known to be associated with risk of glioma, the most common type of malignant brain tumor, mediates its effects in a sex-specific manner. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 19, 2021 Category: International Medicine & Public Health Source Type: news

Australian researchers find new way to target deadly childhood cancer
(Children's Cancer Institute Australia) Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Deadly Brain Tumor: Survival Extended by Oncolytic Virus Product Deadly Brain Tumor: Survival Extended by Oncolytic Virus Product
Improved survival was seen in a small trial in which a genetically engineered version of herpes simplex virus was infused directly into high-grade gliomas.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - April 12, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

MD Anderson researchers highlight advances in clinical studies at the AACR Annual Meeting 2021
(University of Texas M. D. Anderson Cancer Center) Researchers at The University of Texas MD Anderson Cancer Center conducted early phase clinical trials that showed promising results for patients with RET fusion-positive cancers, high-grade and low-grade glioma and ovarian cancer. The results for these studies will be presented at the AACR Annual Meeting 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

New anti-cancer therapy: Converting glioma cells into neurons
(Guangdong-Hongkong-Macau Institute of CNS Regeneration,Jinan University) Glioma is a fatal neurological disorder that has limited interventional treatment, despite extensive research over the past several decades. A research team led by Dr. Gong Chen,has developed a novel gene therapy to reprogram glioma cells into functional neurons, shedding new light on glioma treatment. The work has been published in Cancer Biology& Medicine on March 22, 2021 (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 23, 2021 Category: Cancer & Oncology Source Type: news

Combination treatment for common glioma type shows promise in mice
NIH-funded preclinical study suggests new approach to treat a type of brain tumor (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - February 16, 2021 Category: American Health Source Type: news

Combination treatment for common glioma type shows promise in mice
(NIH/National Institute of Neurological Disorders and Stroke) Gliomas are common brain tumors that comprise about one third of all cancers of the nervous system. In a study funded by the National Institutes of Health (NIH), researchers tested a novel combination treatment approach on mice with tumors with characteristics similar to human astrocytomas and found tumor regression in 60 percent of the mice treated. These encouraging results could be the first step toward developing a treatment for this type of brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 16, 2021 Category: Cancer & Oncology Source Type: news

Can Brain Stem Glioma Be Cured
? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 20, 2021 Category: General Medicine Source Type: news

Toxoplasma Gondii Infection May Be Tied to Higher Risk of Brain Cancer Toxoplasma Gondii Infection May Be Tied to Higher Risk of Brain Cancer
Data from two prospective studies point to an association between Toxoplasma gondii infection and the risk of glioma in adults, suggesting that reducing exposure could provide an avenue to modify glioma risk, the researchers say.Reuters Health Information (Source: Medscape Hiv-Aids Headlines)
Source: Medscape Hiv-Aids Headlines - January 14, 2021 Category: Infectious Diseases Tags: Hematology-Oncology News Source Type: news

Link Between T. gondii Infection, Glioma Risk Examined
Significant increase in glioma risk seen for those with higher antibody titers to the sag - 1 antigen (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 12, 2021 Category: Cancer & Oncology Tags: Infections, Neurology, Oncology, Pathology, Journal, Source Type: news

Toxin in Undercooked Meat Shows Links to Rare Brain Tumors
TUESDAY, Jan. 12, 2021 -- A foodborne pathogen may be linked to a type of rare brain cancer in adults, a new study suggests. Researchers found that people who have glioma are more likely to have antibodies to toxoplasma gondii than a similar group... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 12, 2021 Category: General Medicine Source Type: news

Link Between T. gondii Infection, Glioma Risk Examined
TUESDAY, Jan. 12, 2021 -- Some evidence suggests that there is an increased risk for glioma among individuals who have had Toxoplasma gondii infection, according to a study published online Jan. 11 in the International Journal of Cancer. James M.... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 12, 2021 Category: Pharmaceuticals Source Type: news

Study identifies exposure to common food-borne pathogen linked to rare brain cancer
(American Cancer Society) A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 11, 2021 Category: Cancer & Oncology Source Type: news

Philadelphia biotech firm acquired for $78M by North Carolina company with eye on cancer treatment
The North Carolina biopharmaceutical firm is aiming to boost its pipeline of drugs designed to combat recurrent glioma – a form of brain cancer. (Source: bizjournals.com Health Care News Headlines)
Source: bizjournals.com Health Care News Headlines - January 8, 2021 Category: Health Management Authors: Cameron Snipes Source Type: news

Durham biotech makes $78M deal for Philly firm to boost platform for cancer treatment
The Durham-based biopharmaceutical firm is aiming to boost its pipeline of drugs designed to combat recurrent glioma – a form of brain cancer. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - January 8, 2021 Category: Pharmaceuticals Authors: Cameron Snipes Source Type: news

Durham biotech makes $78M deal for Philly firm to boost platform for cancer treatment
The Durham-based biopharmaceutical firm is aiming to boost its pipeline of drugs designed to combat recurrent glioma – a form of brain cancer. (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - January 8, 2021 Category: American Health Authors: Cameron Snipes Source Type: news

Combination Treatment Fails to Improve Survival in Recurrent Glioma Combination Treatment Fails to Improve Survival in Recurrent Glioma
Following tumor resection in patients with recurrent glioblastoma and anaplastic astrocytoma, treatment with vocimagene amiretrorepvec and with flucytosine provides no improvement in overall survival, according to an open-label phase 2/3 trial.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 5, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Tumor DNA in spinal fluid could help doctors better monitor childhood brain cancer
(Michigan Medicine - University of Michigan) Researchers have demonstrated that a new liquid biopsy approach overcomes traditional barriers to quickly and efficiently diagnose and monitor high-grade pediatric gliomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 21, 2020 Category: Cancer & Oncology Source Type: news

FET-PET offers more info on treatment of brain metastases
Using PET with the radiolabeled amino acid F-18 fluoroethyl-tyrosine (F-18-FET)...Read more on AuntMinnie.comRelated Reading: FET-PET can be useful for glioma evaluations FET-PET adds 'relevant' info to pediatric cancer cases SNMMI: FET-PET could have answers for brainstem glioma SNMMI: FET-PET aids pediatric brain cancer patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 14, 2020 Category: Radiology Source Type: news

The road to recovery: a pilot study of driving behaviors following antibody-mediated encephalitis - Day GS, Babulal GM, Rajasekar G, Stout S, Roe CM.
INTRODUCTION: Safe driving requires integration of higher-order cognitive and motor functions, which are commonly compromised in patients with antibody-mediated encephalitis (AME) associated with N-methyl-D-aspartate receptors or leucine-rich glioma-inacti... (Source: SafetyLit)
Source: SafetyLit - August 31, 2020 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Genomic analysis predicts survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in low-grade gliomas in NRG Oncology clinical trial
(NRG Oncology) A practice-changing study, NRG Oncology clinical trial NRG-RTOG 9802, has demonstrated, for the first time, a survival benefit of adjuvant chemotherapy following radiotherapy over radiotherapy alone in certain subgroups of patients with high-risk, low-grade glioma (WHO classification: LGG, grade II), a type of brain tumor that originates from glial cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 31, 2020 Category: Cancer & Oncology Source Type: news

FEFU scientists are developing genetic methods to understand malignant tumors
(Far Eastern Federal University) Scientists of Far Eastern Federal University (FEFU University) get started studying the formation and survival mechanisms of the brain malignant tumors cells, i.e. glioma, to reveal new ways for diagnosis and therapy for this fatal disease. This research was supported by the grant from Russian Science Foundation (RSF). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 31, 2020 Category: Cancer & Oncology Source Type: news

Drugs against alpha-ketoglutarate may combat deadly childhood brain tumor
(NIH/National Institute of Neurological Disorders and Stroke) Every year, 150 to 300 children in the United States are diagnosed with diffuse intrinsic pontine gliomas (DIPGs), aggressive and lethal tumors that grow deep inside the brain, for which there are no cures. In a study funded by the National Institutes of Health, researchers showed that experimental drugs designed to lower the body's natural production of alpha-ketoglutarate extended the lives of mice harboring DIPG tumors by slowing the growth of the cancer cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 18, 2020 Category: Cancer & Oncology Source Type: news

The structural basis of Focal Adhesion Kinase activation on lipid membranes unravelled
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) * Patients with glioma - a very common type of tumour originating in the brain - see improvement in survival rates with combined treatment of radiotherapy plus temozolomide* Researchers found a novel mechanism on how tumours evade chemotherapy through genomic rearrangements of the MGMT DNA repair gene* This finding is potentially relevant for updating the methods used to monitor temozolomide efficacy. Genomic rearrangement could be a marker to be detected in blood samples and help make therapeutic decisions (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 11, 2020 Category: Cancer & Oncology Source Type: news

A research team of the CNIO and the HKUST identifies how some gliomas develop chemoresistance
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) * Patients with glioma - a very common type of tumour originating in the brain - see improvement in survival rates with combined treatment of radiotherapy plus temozolomide* Researchers found a novel mechanism on how tumours evade chemotherapy through genomic rearrangements of the MGMT DNA repair gene* This finding is potentially relevant for updating the methods used to monitor temozolomide efficacy. Genomic rearrangement could be a marker to be detected in blood samples and help make therapeutic decisions (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 4, 2020 Category: Cancer & Oncology Source Type: news

New treatment strategy may benefit patients with brain cancer
(Massachusetts General Hospital) A team led by investigators at Massachusetts General Hospital has uncovered a potentially promising strategy to treat gliomas with mutations in the IDH genes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 30, 2020 Category: Cancer & Oncology Source Type: news

CNS Announces the FDA has Granted Orphan Drug Designation for Brain Cancer Drug Berubicin
HOUSTON, June 11, 2020 -- (Healthcare Sales & Marketing Network) -- CNS Pharmaceuticals, Inc., (Nasdaq: CNSP) ("CNS" or the "Company"), a biopharmaceutical company specializing in the development of novel treatments for primary and me... Biopharmaceuticals, Oncology, Neurology, FDA CNS Pharmaceuticals, Berubicin, glioma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 11, 2020 Category: Pharmaceuticals Source Type: news

Ludwig Lausanne study charts the immune landscape of multiple brain cancers
(Ludwig Institute for Cancer Research) A Ludwig Cancer Research study has profiled, in a sweeping comparative analysis, the distinct immune landscapes of tumors that arise in the brain, or gliomas, and those that metastasize to the organ from the lungs, breast and skin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 28, 2020 Category: Cancer & Oncology Source Type: news

Brain tumors respond well to combo of radiation, schizophrenia drug
Researchers at theUCLA Jonsson Comprehensive Cancer Center and colleagues have found that adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma, one of the deadliest and most difficult-to-treat brain tumors.The findings,published May 1 in Proceedings of the National Academy of Sciences, show that a combination of radiation and the drug trifluoperazine not only targets glioblastoma cells but also helps overcome the resistance to treatment so common to this aggressive form of cancer. The results could prove promising for patients wit...
Source: UCLA Newsroom: Health Sciences - May 2, 2020 Category: Universities & Medical Training Source Type: news

Could AI Help Doctors Map Out Treatments for Brain Cancers?
FRIDAY, April 24, 2020 -- Artificial intelligence may reduce the need for glioma brain cancer patients to have biopsies to determine the best treatment for their tumors, researchers report. Currently, it's common to remove glioma samples from... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 24, 2020 Category: General Medicine Source Type: news

Study reveals how 'hypermutated' malignant brain tumors escape chemotherapy and immunotherapy
(Dana-Farber Cancer Institute) An analysis of more than 10,000 gliomas and clinical outcomes reported in Nature by scientists in Boston and Paris found that glioma patients whose tumors were hypermutated actually had no significant benefit when treated with checkpoint blockers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 15, 2020 Category: International Medicine & Public Health Source Type: news

Mouse study shows how advancing glioma cells scramble brain function, blood flow
(The Zuckerman Institute at Columbia University) The first sign of trouble for a patient with a growing brain tumor is often a seizure. Such seizures have long been considered a side effect of the tumor. But now a joint team of Columbia engineers and cancer researchers studying brain tumors has found evidence that the seizures caused by an enlarging tumor could spur its deadly progression. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 14, 2020 Category: Biology Source Type: news

New findings shed light on selective therapeutics for IDH1-mutated glioma
(Chinese Academy of Sciences Headquarters) Findings of a new study led by Prof. XU Guowang from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences and Prof. YANG Chunzhang from the National Cancer Institute shed light on the selective therapeutics for IDH1-mutated glioma by targeting glutathione synthesis pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2020 Category: Cancer & Oncology Source Type: news

Virginia Tech scientists reveal brain tumors impact normally helpful cells
(Virginia Tech) Unprovoked recurrent seizures are a serious problem affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Fralin Biomedical Research Institute researchers tested the hypothesis that glioma-induces processes that renders a type of brain cells dysfunctional, perpetuating the imbalance between excitation and inhibition in tumor-associated epilepsy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 6, 2020 Category: International Medicine & Public Health Source Type: news

Babies with brain tumors could benefit from targeted treatment
(Institute of Cancer Research) Brain cancer in infants is biologically distinct from other childhood brain tumors and could be successfully treated with targeted drugs, a new study has shown. In the largest and most comprehensive study of infant gliomas to date, scientists found that these tumors are molecularly different from those in older children, helping explain why they tend to be less aggressive. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2020 Category: Cancer & Oncology Source Type: news

Good news for NF patients with low grade glioma (LGG)
(Children's Tumor Foundation) A paper published in the academic journal Neuro-Oncology by NF experts has demonstrated an increased understanding of low grade gliomas (LGG) occurring in children and adults with NF1. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 31, 2020 Category: Biology Source Type: news