Researchers to study brain cancer with Department of Defense funding
(Henry Ford Health System) Henry Ford Health System's Department of Neurosurgery was awarded a $600,000 grant by the Department of Defense to study the genetic makeup of gliomas, a type of brain cancer, in hope of identifying new therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 18, 2018 Category: Cancer & Oncology Source Type: news

The boy whose clumsiness turned out to be cancer
Atticus Feduchin-Pate, from Whitchurch in Hampshire, has been diagnosed with a terminal high-grade cancer called diffuse intrinsic potine glioma which cannot be operated on. (Source: the Mail online | Health)
Source: the Mail online | Health - September 6, 2018 Category: Consumer Health News Source Type: news

Non-Hispanic White Patients Have Higher Glioma Incidence Non-Hispanic White Patients Have Higher Glioma Incidence
Dr Laurie Barclay comments on a study that aimed to quantify the differences in incidence and survival in adults with glioma by race or ethnicity.Medscape Neurology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 23, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Viewpoint Source Type: news

Georgetown releases cache of brain cancer data
Georgetown Lombardi Comprehensive Cancer Center has released a set of brain...Read more on AuntMinnie.comRelated Reading: FLT-PET points toward survival for glioblastoma patients SNMMI: FET-PET could have answers for brainstem glioma PET/CT helps assess pediatric brain tumor therapy Brain MRI surprises with incidental findings SNMMI: FDOPA-PET/MRI monitors pediatric brain tumors (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - August 15, 2018 Category: Radiology Source Type: news

Researchers use microparticles for targeted delivery of brain cancer therapy
Credit: Christine Daniloff/MIT A team of researchers from Brigham & Women’s Hospital, Mass. Institute of Technology and Mass. General Hospital demonstrated that localizing the delivery of NAMPT inhibitors can extend survival in a mouse model of glioma, according to a paper published this week in the Proceedings of the National Academy of Sciences. The scientists created a test to check for a mutation linked to glioma and implanted microparticles that slowly elute drug over the course of several days or even weeks to treat the brain cancer. Get the full story at our sister site, ...
Source: Mass Device - August 7, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Oncology Pharmaceuticals Research & Development Brigham & Women's Hospital Massachusetts General Hospital Massachusetts Institute of Technology Source Type: news

A targeted approach to treating glioma
(Massachusetts Institute of Technology) Researchers from MIT, Brigham and Women's Hospital, and Massachusetts General Hospital have developed a new way to treat low-grade glioma. They devised a test that can rapidly check for the IDH mutation during brain surgery, and if the mutation is present, they can implant microparticles that gradually release an IDH-targeted drug over several days or weeks. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 6, 2018 Category: Biology Source Type: news

Rapid diagnostic coupled with local therapy developed for brain tumors
(Brigham and Women's Hospital) Working together, researchers from Brigham and Women's Hospital (BWH) and neurosurgeons from Massachusetts General Hospital (MGH), along with colleagues at MIT, are designing a new, rapid molecular diagnostic and sustained release therapeutic that could be deployed during brain surgery to treat gliomas and prevent their return. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 6, 2018 Category: Cancer & Oncology Source Type: news

Rapid Diagnostic Coupled with Local Therapy Developed for Brain Tumors
Interdisciplinary team develops rapid molecular diagnostic coupled to sustained release therapeutic to treat gliomas during surgery (Source: BWH News)
Source: BWH News - August 6, 2018 Category: Hospital Management Source Type: news

Chinese goldthread might offer the ideal treatment for people with brain cancer
(Natural News) Roughly sixty percent of all brain cancer are gliomas, a tumor that starts in the glial cells of the brain or the spine. There are many different grades of gliomas; each describing a variance in growth potential and aggressiveness. Regardless, conventional therapies involving radiation and chemotherapy drugs have been shown to be inconsistent... (Source: NaturalNews.com)
Source: NaturalNews.com - July 31, 2018 Category: Consumer Health News Source Type: news

FLT-PET points toward survival for glioblastoma patients
PET scans with the radiotracer F-18 fluorothymidine (FLT) can help determine...Read more on AuntMinnie.comRelated Reading: SNMMI: PET, MRI may predict pediatric brain tumor outcomes FDG-PET/CT beats FLT-PET/CT for differentiated thyroid cancer FLT-PET could help predict outcome in head and neck cancer JNM: FLT-PET aids prognosis of glioma patients FLT-PET helps predicts cancer therapy results (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - July 26, 2018 Category: Radiology Source Type: news

TGen opens DIPG tissue donation portal to accelerate research
(The Translational Genomics Research Institute) A tissue donation portal opened today at TGen, which will advance research towards new treatments for an aggressive brain cancer that mostly strikes young children. This new portal will accelerate the ability of families of children with DIPG -- or Diffuse Intrinsic Pontine Glioma -- to help TGen build a tissue bank that will aid researchers in their investigations of this rare and currently incurable disease that strikes about 350 children in the US each year. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 17, 2018 Category: Cancer & Oncology Source Type: news

Glioma Incidence, Survival in US Adults Vary by Ethnicity Glioma Incidence, Survival in US Adults Vary by Ethnicity
The incidence and survival rates of glioma in U.S. adults vary greatly by race or ethnicity, new research suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 13, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Treating Gliomas Via Preoperative nTMS and Tractography Treating Gliomas Via Preoperative nTMS and Tractography
The authors present a novel multimodal approach to awake surgery for language-eloquent gliomas using preoperative nTMS and nTMS-based diffusion tensor imaging fiber tracking.Neurosurgical Focus (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 13, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Polio-Rhinovirus Promising for Malignant Glioma Patients
THURSDAY, July 12, 2018 -- Intratumoral infusion of recombinant nonpathogenic polio-rhinovirus chimera (PVSRIPO) can be delivered safely and is tied to higher survival rates than those of historical controls, according to a study published in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 12, 2018 Category: Pharmaceuticals Source Type: news

MGMT promoter methylation associated with improved survival for patients with WHO Grade II Gliomas
(NRG Oncology) Further exploration into the endpoints of the NRGOncology/RTOG 0424 trial resulted in the discovery that MGMT promoter methylation is an independent prognostic biomarker of high-risk, low-grade glioma treated with temozolomide and radiation. This is the first study of its kind to validate the prognostic significance of MGMT promoter methylation in this patient population and treatment regimen. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 5, 2018 Category: Cancer & Oncology Source Type: news

A first look at interstitial fluid flow in the brain
(American Institute of Physics) Past research has shown a link between interstitial fluid flow and an increased invasion rate of glioblastoma cells, and biomedical researchers and electrical engineers recently developed a new method to measure and reconstruct interstitial fluid flow velocities in the brain. This method gives a first look at interstitial fluid flow dynamics in glioma models, and the technique can readily translate to clinical models already using contrast-enhanced MRI. The team describes their method in APL Bioengineering. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 3, 2018 Category: International Medicine & Public Health Source Type: news

MGMT Methylation a Survival Biomarker in High-Risk Low-Grade Gliomas?
These are the first data to highlight the prognostic value ofMGMTmethylation beyond theIDH1/2 mutation status test currently used to help predict glioma patient survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - June 29, 2018 Category: Cancer & Oncology Authors: John Schieszer Source Type: news

Delivery Device Sends'Chemosurgery' to Brainstem Tumor Delivery Device Sends'Chemosurgery' to Brainstem Tumor
Convection-enhanced drug infusion achieves high local concentrations with little or no systemic exposure in children with inoperable pontine glioma.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 29, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Living With Cancer: Understanding glioma
Glioma? Glioma is one of the most common types of primary brain tumors and can occur in the brain and spinal cord. Gliomas begin in the glial cells ? the gluey supportive cells that surround nerve cells and help them function. A glioma can affect your brain function and be life-threatening, depending on its location [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 29, 2018 Category: Databases & Libraries Source Type: news

Men and women have different genetic risk factors for developing brain cancer
(Case Western Reserve University) A team from Case Western Reserve University School of Medicine, together with an international consortium of researchers, have discovered that men and women have different genetic risk factors for developing glioma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 28, 2018 Category: Cancer & Oncology Source Type: news

Novel nuclear medicine approach shows promise for treating wide array of cancerous tumors
(Society of Nuclear Medicine and Molecular Imaging) A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children. The research was presented today at the SNMMI 2018 Annual Meeting, June 23-26 in Philadelphia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: news

Girl, 3, with an inoperable brain tumour may now survive
Edie Molyneux, from Tranmere, Wirral, was expected to die young because of the rare mass on her brain, known as a diffuse intrinsic pontine glioma (DIPG). (Source: the Mail online | Health)
Source: the Mail online | Health - June 20, 2018 Category: Consumer Health News Source Type: news

New Fibrillarin Antibody
Potent Nucleoli MarkerGiven the importance ofNucleus and Related Markers to all branches of cell/molecular biology, we are dedicated to having the best.We have just added a newFibrillarin Antibody.Images: Immunofluorescent analysis of (A) C6 rat glioma cells and (B) Human embryonic kidney cells stained with mouse mAb to fibrillarin, MO22169, dilution 1:1,000 in red, in both cases costained with chicken pAb to vimentin, CPCA-Vim, dilution 1:10,000 in green. The blue is DAPI staining of nuclear DNA.Nop1p/Fibrillarin was originally identified as a nucleolar protein of bakers yeast, Saccharomyces cerevisiae (accession P15646)....
Source: Neuromics - June 4, 2018 Category: Neuroscience Tags: Fibrillarin Antibody Nuclear Staining Nucleoli Source Type: news

New study points to a potential 'Achilles heel' in brain cancer
(Virginia Commonwealth University) Scientists at Virginia Commonwealth University believe they have uncovered an 'Achilles heel' of glioblastoma multiforme (GBM), the most common and deadly form of brain cancer. Their study published this week in the Proceedings of the National Academy of Sciences details how a mechanism that protects glioma stem cells can potentially be exploited to develop new and more effective treatments for GBM. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 4, 2018 Category: Cancer & Oncology Source Type: news

MR spectroscopy imaging reveals effects of targeted treatment of mutant IDH1 gliomas
(Massachusetts General Hospital) Using a novel imaging method, a Massachusetts General Hospital research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 18, 2018 Category: International Medicine & Public Health Source Type: news

Operating on brain gliomas by detecting the 'glow'
(St. Joseph's Hospital and Medical Center) Research by Barrow Neurological Institute physicians and University of Washington scientists on novel imaging technology for malignant brain tumors was published in the April issue of World Neurosurgery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 9, 2018 Category: Cancer & Oncology Source Type: news

Persistence pays off in discovery that could lead to improved treatment and survivability of patient
(Huntsman Cancer Institute) Gliomas are the most common type of central nervous system cancer but how these tumors develop is not fully understood. Sheri Holmen, PhD a researcher at Huntsman Cancer Institute (HCI) and professor of surgery at the University of Utah just published the results of her research on gliomas in Cell Reports. The work is focused on a mutated gene that is a critical piece of the puzzle for glioma development, according to Holmen's work. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 1, 2018 Category: International Medicine & Public Health Source Type: news

Glioma subtypes determine how the dangerous tumors spread, evade anti-angiogenic treatment
(Massachusetts General Hospital) A multi-institutional research team led by investigators at Massachusetts General Hospital and the University of California San Francisco has identified a new mechanism by which the dangerous brain tumors called gliomas develop resistance to anti-angiogenic treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 27, 2018 Category: Cancer & Oncology Source Type: news

Tocagen and ApolloBio Enter License Agreement to Develop and Commercialize Toca 511 and Toca FC in the Greater China Region
Tocagen eligible to receive up to $127 million in upfront payment, development and commercial milestones, plus additional double-digit tiered sales royalties Upfront and near-term development milestones payments total up to $20 million SAN DIEGO and ... Biopharmaceuticals, Oncology, Licensing Tocagen, ApolloBio, immunotherapy, high grade glioma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 19, 2018 Category: Pharmaceuticals Source Type: news

The cellular composition of H3K27M gliomas
(Source: ScienceNOW)
Source: ScienceNOW - April 19, 2018 Category: Science Authors: Zahn, L. M. Tags: Genetics, Medicine, Diseases twis Source Type: news

Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a cooperation between genetics and cellular context in tumorigenesis. Although the genetics of H3K27M-glioma are well characterized, their cellular architecture remains uncharted. We performed single-cell RNA sequencing in 3321 cells from six primary H3K27M-glioma and matched models. We found that H3K27M-glioma primarily contain cells that resemble oligodendrocyte precursor cells (OPC-like), whereas more differentiated malignant cells are a minority. OPC-like ce...
Source: ScienceNOW - April 19, 2018 Category: Science Authors: Filbin, M. G., Tirosh, I., Hovestadt, V., Shaw, M. L., Escalante, L. E., Mathewson, N. D., Neftel, C., Frank, N., Pelton, K., Hebert, C. M., Haberler, C., Yizhak, K., Gojo, J., Egervari, K., Mount, C., van Galen, P., Bonal, D. M., Nguyen, Q.-D., Beck, A., Tags: Genetics, Medicine, Diseases reports Source Type: news

Biomarkers may help predict brain tumor recurrence, study says
Specific biomarkers have been identified that could help assess the likelihood and severity of the recurrence of malignant glioma, a form of brain cancer. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 11, 2018 Category: Consumer Health News Source Type: news

Newly discovered biomarkers could be key to predicting severity of brain tumor recurrence
(Henry Ford Health System) Researchers have identified predictive biomarkers that could help assess the level of risk for recurrence in patients with malignant glioma. The study, led by Henry Ford Health System, was published today in Cell Reports. In an analysis of 200 tumor samples, the authors identified a set of epigenetic biomarkers that can predict, at a patient's initial diagnosis, which tumors are likely to recur with a more aggressive tumor type. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2018 Category: Cancer & Oncology Source Type: news

Biomarker panel can guide treatment of brain cancer
(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) Brazilian researchers have identified seven biomarkers that could be used at the time of the primary diagnosis to show which glioma patients will tend to progress to a more aggressive form of the disease (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 10, 2018 Category: International Medicine & Public Health Source Type: news

AI Beats Pathologists in Predicting Survival in Brain Cancer AI Beats Pathologists in Predicting Survival in Brain Cancer
A novel approach using artificial intelligence (AI) performed better than human pathologists when predicting overall survival for patients with gliomas.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 21, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Machines See the Future for Patients Diagnosed with Brain Tumors
For patients diagnosed with glioma, a deadly form of brain tumor, the future can be very uncertain. While gliomas are often fatal within two years of diagnosis, some patients can survive for 10 years or more. Predicting the course of a patient's disease at diagnosis is critical in selecting the right therapy and in helping patients and their families to plan their lives. (Source: eHealth News EU)
Source: eHealth News EU - March 14, 2018 Category: Information Technology Tags: Featured Research Research and Development Source Type: news

Machines see the future for patients diagnosed with brain tumors
(Emory Health Sciences) Researchers at Emory and Northwestern Universities have developed artificial intelligence (AI) software that can predict the survival of patients diagnosed with glioma by examining data from tissue biopsies. The approach is more accurate than the predictions of doctors who undergo years of highly-specialized training for the same purpose. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 13, 2018 Category: International Medicine & Public Health Source Type: news

Response of High-Grade Gliomas to Checkpoint Inhibitors Response of High-Grade Gliomas to Checkpoint Inhibitors
How should MRI findings be used to assess response of high-grade gliomas to immunotherapy?Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 13, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Scientists target glioma cancer stem cells, which could improve patient survival
(Dartmouth-Hitchcock Medical Center) Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers at Dartmouth's Norris Cotton Cancer Center have devised a strategy to treat these tumors by identifying a secretion-mediated pathway that's essential for maintaining glioma cancer stem cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 5, 2018 Category: International Medicine & Public Health Source Type: news

Girl, 3, with brain tumour struggles to feed herself
Edie Molyneux, from Tranmere, will likely die young because of the rare mass on her brain, known as a diffuse intrinsic pontine glioma. (Source: the Mail online | Health)
Source: the Mail online | Health - January 25, 2018 Category: Consumer Health News Source Type: news

Tailoring cancer treatments to individual patients
(University of Texas at Austin, Texas Advanced Computing Center) The Center for Computational Oncology developed computer models to predict how cancer will progress in a specific individual, based on tissue, cellular and subcellular protein signaling responses. The models can predict how brain tumors (gliomas) will grow with much greater accuracy than previous models. Recently, the group began a clinical study to predict how an individual's cancer will progress after one cycle of therapy, and to use that prediction to plan the course of treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 3, 2018 Category: International Medicine & Public Health Source Type: news

Variation Seen in Hospice Use for Malignant Glioma
Differences by race, sex, age, level of education, urban versus rural residence identified (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - December 28, 2017 Category: Cancer & Oncology Tags: Family Medicine, Geriatrics, Internal Medicine, Neurology, Nursing, Oncology, Anesthesiology & amp; Pain, Journal, Source Type: news

Many brain tumor patients do not receive adequate end-of-life care
(Massachusetts General Hospital) While more than 60 percent of patients with the brain tumors called malignant gliomas enroll in hospice services, almost a quarter of them do so within a week of death, probably too late for patients and family members to benefit from hospice care. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - December 20, 2017 Category: Cancer & Oncology Source Type: news

UCLA grant program funds interdisciplinary brain cancer research
When a neurosurgeon looks at a glioblastoma, an aggressive form of brain cancer, she sees a dark mass bullying its way through the brain. When an oncologist talks to a patient with glioblastoma, he tempers expectations, talking in months rather than years. When a molecular biologist thinks about glioblastoma, she thinks about the tumor ’s sweet tooth — the sugar it consumes to fuel its frenetic growth. And when you put all these people together — you get a plan to fight cancer.Armed with new research tools and a grant from the David Geffen School of Medicine ’s newSeed Grant Program, a team of UCLA ...
Source: UCLA Newsroom: Health Sciences - December 18, 2017 Category: Universities & Medical Training Source Type: news

Novel mechanism that protects from glioblastoma identified
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) A group of researchers at the Spanish National Cancer Research Centre (CNIO) have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression. Moreover, reconstitution of RanBP6 in a mouse xenograft model leads to reduction in tumor growth. Authors state that these findings might have " important clinical implications " . (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - December 18, 2017 Category: Biology Source Type: news

25% of high-grade glioma patients alive 3 years post trial
Patients with recurrent high-grade glioma were treated by the University of Minnesota Medical School. Median survival was 14.4 months, compared with the typical 8 months. (Source: the Mail online | Health)
Source: the Mail online | Health - November 7, 2017 Category: Consumer Health News Source Type: news

Onalespib could be an effective treatment for glioblastoma, preclinical studies show
This study showed that the targeted drug onalespib reduced the expression of cell-survival proteins such as AKT and endothelial growth factor receptor in glioma cell lines and glioma stem cells from patient tumors. This, in turn, reduced the survival, proliferation, invasion and migration of the cells. In animal models of glioblastoma the agent crossed the blood-brain barrier and showed effectiveness as a single agent and greater effectiveness in combination with temozolomide. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 2, 2017 Category: International Medicine & Public Health Source Type: news

25% of high-grade glioma patients live 3 years after trail
Patients with recurrent high-grade glioma were treated by the University of Minnesota Medical School. Median survival was 14.4 months, compared with the typical 8 months. (Source: the Mail online | Health)
Source: the Mail online | Health - November 1, 2017 Category: Consumer Health News Source Type: news

Gene Therapy May Fight Brain Cancer's Return
FRIDAY, Oct. 27, 2017 -- A new form of gene therapy shows promise in battling recurrent brain cancer. The phase 1 clinical trial included 56 patients with recurrent high-grade glioma brain cancer. Three years after the gene therapy treatment, more... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 27, 2017 Category: General Medicine Source Type: news