Hormonal Contraception Use in Younger Women Linked to Glioma Risk (FREE)
By Kelly Young Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM Use of hormonal contraceptives is associated with elevated risk for brain glioma in … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 22, 2015 Category: Primary Care Source Type: news

Overturning dogma to open the black box of DIPG
We report and comment on medical innovations and advances – from bench to bedside – touching on scientific, business and policy issues. Our ranks include science writers, physicians, lab researchers, market analysts and others inside and outside the hospital. By Tom Ulrich You can't advance the care of a disease that you can't study. And for 40 years, that was the case with a rare, uniformly fatal pediatric brain tumor called diffuse intrinsic pontine glioma, or DIPG. Boston Children's HospitalNews Well, Vector Blog, Big Data, Blogread more (Source: Mass Device)
Source: Mass Device - January 16, 2015 Category: Medical Equipment Authors: MassDevice Tags: Vector Blog Source Type: news

Laser Interstitial Thermal Therapy for Recurrent HG Glioma?Laser Interstitial Thermal Therapy for Recurrent HG Glioma?
While promising in some cases, this commentary questions whether there is sufficient evidence to support laser interstitial thermal therapy as a general alternative to resection for high-grade glioma. Neurosurgical Focus (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 16, 2015 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Gene Therapy Approaches Using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
Animal models have proven invaluable for progress toward greater understanding of the etiology, pathogenesis, and genetics of a wide range of human diseases. The development of relevant brain tumor animal models is a critical resource for building our understanding of cancers that arise within the brain and for the development of novel therapies. The central role of these models is particularly apparent for gliomas, which are common and devastating primary brain tumors. Effective models accurately demonstrate pathological features and behavior that are analogous to the human disease. Models aim to develop tumors with high ...
Source: Springer protocols feed by Neuroscience - January 10, 2015 Category: Neuroscience Source Type: news

Seminars in Oncology: "Genomic Characterization of Disease Evolution in Glioma"
Guest Speaker: Roeland Verhaak, MD, PhD The University of Texas MD Anderson Cancer Center Houston, TX Tuesday, January 13, 2015, 4PM Jimmy Fund Auditorium (35 Binney Street) (Source: DF/HCC: Latest News)
Source: DF/HCC: Latest News - January 7, 2015 Category: Cancer & Oncology Tags: Announcements Source Type: news

Important gene interaction defined that drives aggressive brain cancer
Targeted therapies are a growing and groundbreaking field in cancer care in which drugs or other substances are designed to interfere with genes or molecules that control the growth and survival of cancer cells. Now, scientists have identified a novel interaction between a microRNA and a gene that could lead to new therapies for the most common and deadly form of brain tumor, malignant glioma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 11, 2014 Category: Science Source Type: news

Scientists define important gene interaction that drives aggressive brain cancer
(Virginia Commonwealth University) Targeted therapies are a growing and groundbreaking field in cancer care in which drugs or other substances are designed to interfere with genes or molecules that control the growth and survival of cancer cells. Now, scientists at Virginia Commonwealth University Massey Cancer Center have identified a novel interaction between a microRNA and a gene that could lead to new therapies for the most common and deadly form of brain tumor, malignant glioma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 11, 2014 Category: Global & Universal Source Type: news

New study identifies first gene associated with familial glioma
(Baylor College of Medicine) An international consortium of researchers led by Baylor College of Medicine has identified for the first time a gene associated with familial glioma -- brain tumors that appear in two or more members of the same family -- providing new support that certain people may be genetically predisposed to the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 7, 2014 Category: Global & Universal Source Type: news

Reader Poll: Are You Concerned About Cell Phone/Glioma Link?Reader Poll: Are You Concerned About Cell Phone/Glioma Link?
More information on the subject shows that frequent and long-term use of wireless phones triples the risk for brain cancer. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 26, 2014 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

ANH-Intl News Alerts: Week 47, 2014
No to fluoride, family meals, GM, Saatchi’s Medical Innovation Bill, cell phones and brain tumours, omega-3 levels in farmed fish, and EC chief scientific advisor role is scrapped (Source: Alliance for Natural Health)
Source: Alliance for Natural Health - November 19, 2014 Category: Complementary Medicine Authors: Yvonne Tags: Anne Glover Brain tumour cell phone chief scientist. EMR europe fluoride gliomas GM GMO international meals Medical Innovation Bill mobile phone omega-3 Saatchi salmon Source Type: news

Potential therapy found for incurable pediatric brain tumor
(Northwestern University) scientists have discovered a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer.By inhibiting the tumor-forming consequences of the mutation using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with pediatric brainstem glioma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 17, 2014 Category: Cancer & Oncology Source Type: news

“Potential Therapy Found for Incurable Pediatric Brain Tumor,” Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Northwestern Medicine scientists have discovered a new potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation found in children with the cancer. By inhibiting the tumor-forming consequences of the mutation using an experimental drug called GSKJ4, they delayed tumor growth and prolonged survival in mice with pediatric brainstem glioma. Robert H. Lurie Comprehensive Cancer Center at Northwestern University is one of the 25 NCCN Member Institutions.... (Source: National Comprehensive Cancer Network)
Source: National Comprehensive Cancer Network - November 17, 2014 Category: Cancer & Oncology Source Type: news

Chemotherapy following radiation treatment slows disease progress
(Mayo Clinic) A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone. The findings were part of the results of a Phase III clinical trial presented today at the Society for Neuro-Oncology's 19th Annual Meeting in Miami by the study's primary author Jan Buckner, M.D., deputy director, practice, at Mayo Clinic Cancer Center. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2014 Category: Global & Universal Source Type: news

Chemotherapy Following Radiation Treatment Slows Disease Progress and Improves Overall Survival in Adults with Low-Grade Brain Cancer
http://www.youtube.com/watch?v=pdi8vCwvfA4   MIAMI — A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine (PCV) administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone. The findings were part of the results of a Phase III clinical trial presented today at the Society for Neuro-Oncology’s 19th Annual Meeting [...] (Source: Mayo Clinic Rochester News)
Source: Mayo Clinic Rochester News - November 15, 2014 Category: Hospital Management Source Type: news

Long-Term Cell Phone Use Linked to Brain Tumor Risk Long-Term Cell Phone Use Linked to Brain Tumor Risk
The most recent study results show that the risk for glioma triples with long-term exposure to radiofrequency electromagnetic fields emitted by wireless phones. Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - November 14, 2014 Category: Internal Medicine Tags: Neurology & Neurosurgery News Source Type: news

Long-term mobile phone use and brain cancer
Conclusion This case-control study found mobile phone use is associated with an increased risk of the commonest type of brain tumour, glioma. But this type of study cannot prove that mobile phone use caused the brain tumours, as it cannot account for confounding factors. Indeed, despite collecting data on variables such as exposure to chemicals and occupation, this information was not taken into account during the statistical analyses. A further limitation of the study was that the extent of mobile phone use was estimated retrospectively up to a 25-year time period. It is highly unlikely these estimates would be accurate...
Source: NHS News Feed - November 13, 2014 Category: Consumer Health News Tags: Cancer Source Type: news

A Little Boy with Big Impact
This story was produced in partnership with Facebook Stories. Submit your own Facebook story here. --- Last month, our lives changed forever just a few days before my son Chad's fourth birthday. Chad was diagnosed with an inoperable brain tumor known as diffuse intrinsic pontine glioma or DIPG. There are very few treatment options and an extremely low survival rate. That night after we got the news, I couldn't sleep. I was up all night thinking of Chad and our family, and praying for the best. By the time the sun came up, God had put it on my heart to spread Chad's story. The more people we had praying for Chad, the bet...
Source: Healthy Living - The Huffington Post - November 12, 2014 Category: Consumer Health News Source Type: news

Do mobile and cordless phones raise the risk of brain cancer?
The odds of developing glioma, an often deadly brain cancer, rose with years and hours of use, researchers reported in the journal Pathophysiology. (Source: the Mail online | Health)
Source: the Mail online | Health - November 12, 2014 Category: Consumer Health News Source Type: news

Common chemotherapeutic agent reduces resistance to virus therapy in brain tumor patients
The common chemotherapeutic agent cyclophosphamide can help improve the success of oncolytic virus therapy in patients with malignant gliomas, a common type of brain tumor, researchers have found. Oncolytic virus therapy is an innovative therapeutic approach that uses viruses to target and kill cancer cells. The viruses can be modified to allow them to target specific cancer cells or to deliver therapy-modifying genes. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 12, 2014 Category: Science Source Type: news

Polio - Rhinovirus Promising for Malignant Glioma Patients
Intratumoral infusion appears to be safe, improve survival in those with grade IV malignant glioma (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 11, 2014 Category: Cancer & Oncology Tags: Infections, Neurology, Oncology, Journal, Source Type: news

Merrimack begins Phase I trial of MM-398 to treat brain cancer
Merrimack Pharmaceuticals has started enrolling patients in its Phase I clinical trial of MM-398 (nanoliposomal irinotecan injection) in a highly concentrated formulation to treat recurrent high grade glioma, a type of aggressive brain tumor with poo… (Source: Drug Development Technology)
Source: Drug Development Technology - November 7, 2014 Category: Pharmaceuticals Source Type: news

Missed Lauren Hill’s first college basketball game? Here’s how to catch it on TV
If you didn't get a chance to watch the heart-rending performance of Lauren Hill on Sunday playing one college basketball game for Mount St. Joseph University, you can catch the rebroadcast. Fox Sports Ohio, which televised the sold-out game on Sunday afternoon, said it will rebroadcast the Mount St. Joseph game against Hiram College on Thursday at 8 p.m. Hill is a college freshman from Lawrenceburg, Ind., who was diagnosed late last year with Diffuse Intrinsic Pontine Glioma (DIPG), a rare form… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - November 4, 2014 Category: American Health Authors: Steve Watkins Source Type: news

Characterization and Analysis of Extracellular Matrix in Malignant Brain Tumors and Their Cellular Derivatives
The neural extracellular matrix (ECM) is a key regulator of cellular phenotype in normal and diseased states. Analytical approaches have helped uncover the myriad of roles the ECM plays in a variety of diseases including malignant gliomas, the most prevalent and deadly primary brain tumors. Major components of the glioma ECM include secreted proteoglycans as well as basal lamina proteins such as laminins. Characterization of secreted proteoglycans by protein blotting is an invaluable tool to understand their molecular complexity. To provide complete characterization of these molecules, tissue specimens must be first proces...
Source: Springer protocols feed by Neuroscience - November 4, 2014 Category: Neuroscience Source Type: news

New findings show that different brain tumors have the same origin
(Uppsala University) Glioma is a common name for serious brain tumors. Different types of glioma are usually diagnosed as separate diseases and have been considered to arise from different cell types in the brain. Now researchers at Uppsala University have shown that one and the same cell of origin can give rise to different types of glioma. This is important for the basic understanding of how these tumors are formed and can contribute to the development of more efficient and specific glioma therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 28, 2014 Category: Global & Universal Source Type: news

Case Western researchers awarded $250,000 to develop an effective treatment for childhood brain tumors
(Case Western Reserve University) Prayers from Maria Children's Glioma Cancer Foundation announced today that it will award its $250,000 Melana Matson Memorial Grant -- its third major research grant since 2010 -- to Case Western Reserve University, Case Comprehensive Cancer Center researchers James Basilion, Ph.D., Efstathis Karathanasis, Ph.D., and John Letterio, M.D., who are studying the use of nanotechnology to more effectively treat pediatric glioma brain tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 27, 2014 Category: Cancer & Oncology Source Type: news

Agios begins Phase I/II trial of AG-221 to treat advanced solid tumours
Agios Pharmaceuticals has started a Phase I/II multicentre trial of AG-221 in patients with advanced solid tumours, including gliomas, as well as angioimmunoblastic T-cell lymphoma (AITL) that carry an isocitrate dehydrogenase-2 (IDH2) mutation. (Source: Drug Development Technology)
Source: Drug Development Technology - October 22, 2014 Category: Pharmaceuticals Source Type: news

Overexpression of Notch1 in temporal lobe epilepsy
(Neural Regeneration Research) Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 21, 2014 Category: Global & Universal Source Type: news

Markey researchers develop web-based app to predict glioma mutations
(University of Kentucky) A new web-based program developed by University of Kentucky Markey Cancer Center researchers will provide a simple, free way for healthcare providers to determine which brain tumor cases require testing for a genetic mutation. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 19, 2014 Category: Biology Source Type: news

A Diphtheria Toxin Negative Selection in RNA Interference Screening
RNA interference (RNAi) screening is a powerful technique for understanding the molecular biology of cancer and searching drug targets. Genes and their upstream activators that are essential for the survival of cancer cells often dictate cancer formation/progression. Hence, they are preferable therapeutic targets. Identifying these genes using RNAi is, however, problematic because knocking them down leads to cell death. Here we describe a diphtheria toxin (DT) negative selection method to circumvent the problem of cell death in RNAi screening. DT fails to kill mouse cells due to the lack of functional DT receptor (DTR). Th...
Source: Springer protocols feed by Cancer Research - July 17, 2014 Category: Cancer & Oncology Source Type: news

'Profound Extension of Survival' in Glioma Study'Profound Extension of Survival' in Glioma Study
Mature data from a phase 3 study confirm longer overall and progression-free survival in low-grade glioma treated with radiation plus chemotherapy. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 11, 2014 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Longer Telomeres, Considered Sign of Good Health, Linked to Brain Cancer Risk
Research conducted by Mayo Clinic investigators has found that two common gene variants that lead to longer telomeres — the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging — also significantly increase the risk of developing gliomas, a deadly form of brain cancer. The genetic variants, in [...] (Source: Mayo Clinic Rochester News)
Source: Mayo Clinic Rochester News - June 10, 2014 Category: Hospital Management Source Type: news

Longer telomeres linked to risk of brain cancer: Double-edged sword, gene variants may promote overall health while increasing risk of gliomas
New genomic research reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 8, 2014 Category: Science Source Type: news

Longer telomeres linked to risk of brain cancer
(University of California - San Francisco) New genomic research led by UC San Francisco scientists reveals that two common gene variants that lead to longer telomeres, the caps on chromosome ends thought by many scientists to confer health by protecting cells from aging, also significantly increase the risk of developing the deadly brain cancers known as gliomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 8, 2014 Category: Global & Universal Source Type: news

Newly identified brain cancer mutation will aid drug development
New genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma has been identified by an international team of researchers. The researchers identified a genetic mutation in the tumor cells that plays a role in both the growth and the death of a cell. Additionally, the mutation to the newly identified gene may also contribute to the tumor’s resistance to radiation. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 1, 2014 Category: Science Source Type: news

Chemotherapy following radiation treatment improves progression-free survival
(Mayo Clinic) A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone. The findings were part of the results of a Phase III clinical trial presented today at the 2014 American Society of Clinical Oncology Annual Meeting by the study's primary author Jan Buckner, M.D., deputy director, Cancer Practice, at Mayo Clinic Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2014 Category: Cancer & Oncology Source Type: news

Newly identified brain cancer mutation will aid drug development
(Duke University Medical Center) A collaborative effort between Duke Medicine researchers and neurosurgeons and scientists in China has produced new genetic insights into a rare and deadly form of childhood and young adult brain cancer called brainstem glioma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 1, 2014 Category: Cancer & Oncology Source Type: news

Chemotherapy following radiation treatment improves progression-free survival and overall survival in adults with low-grade brain cancer
http://www.youtube.com/watch?v=pdi8vCwvfA4 CHICAGO — A chemotherapy regimen consisting of procarbazine, CCNU, and vincristine (PCV) administered following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas, a form of brain cancer, when compared to radiation therapy alone. The findings were part of the results of a Phase III clinical trial presented today at [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - May 29, 2014 Category: Databases & Libraries Source Type: news

Study linking brain cancer and mobiles inconclusive
Conclusion This French case-control study finds no association between regular mobile phone use (defined as phoning at least once a week for six months or more) and risk of the most common types of brain tumour. However, it does find increased risk with the heaviest use (cumulative lifetime call duration above 896 hours). There are important considerations to bear in mind: This study is only representative of people diagnosed with brain tumour in these four regions of France between 2004 and 2006, and their matched controls. They may not be representative of all mobile phone users in France or elsewhere. The average ag...
Source: NHS News Feed - May 14, 2014 Category: Consumer Health News Tags: Cancer Source Type: news

Overexpression of Notch1 in temporal lobe epilepsy
(Neural Regeneration Research) Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 9, 2014 Category: Biology Source Type: news

Hope for children with previously incurable brain cancer
Potential treatment targets for a previously incurable form of pediatric brain cancer called Diffuse Intrinsic Pontine Glioma has been revealed by scientists. The researchers believe that this discovery could lead to better treatment. "We're hoping that by having a better genetic characterization of these cancers we can try to better target these tumors and provide a personalized approach to treatment," one expert noted. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 7, 2014 Category: Science Source Type: news

Gene sequencing project discovers mutations tied to deadly brain tumors in young children
New mutations in pediatric brain tumors known as high-grade gliomas, which most often occur in the youngest patients, have been discovered by researchers. The discoveries stem from the most comprehensive effort yet to identify the genetic missteps driving these deadly tumors. The results provide desperately needed drug development leads, particularly for agents that target the underlying mutations. This and other studies show these mutations often differ based on patient age. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 7, 2014 Category: Science Source Type: news

Nature Genetics online: April 6, 2014
Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations Pawel Buczkowicz, Christine Hoeman, Patricia Rakopoulos, Sanja Pajovic, Louis Letourneau, Misko Dzamba, Andrew Morrison, Peter Lewis, Eric Bouffet, … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - April 6, 2014 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Gene sequencing project discovers mutations tied to deadly brain tumors in young children
(St. Jude Children's Research Hospital) The St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project has identified new mutations in pediatric brain tumors known as high-grade gliomas, which most often occur in the youngest patients. The research appears today as an advance online publication in the scientific journal Nature Genetics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 6, 2014 Category: Cancer & Oncology Source Type: news

Gene sequencing project discovers mutations tied to deadly brain tumors in young children
St. Jude Children’s Research Hospital-Washington University Pediatric Cancer Genome Project offers new leads to improved outcomes for children with high-grade glioma brain tumors; particularly youngest patients. (Suzanne Baker, PhD, and Jinghui Zhang, PhD) (Source: St. Jude Children's Research Hospital)
Source: St. Jude Children's Research Hospital - April 6, 2014 Category: Pediatrics Source Type: news