Implanted Ultrasound Lets Chemo Access Brain
Researchers at Northwestern University have trailed an implanted ultrasound device in patients, which is used in combination with microbubbles to transiently open pores in the blood brain barrier, allowing chemo drugs to enter. We have reported on this technique before as a lab-based concept (see flashbacks below), but this is the first time that it has actually been trialed in human patients, in this case patients with glioblastoma, a difficult to treat brain cancer. The approach successfully led to a four- to six-fold increase in chemo concentrations in the brain, using drugs that are not otherwise able to cross the bloo...
Source: Medgadget - May 12, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Neurology Neurosurgery Oncology Radiology glioblastoma northwestern Source Type: blogs

Fight Aging! Newsletter, January 30th 2023
In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes. Communication Between Blood and Brain in Aging and Rejuvenation https://www.fightaging.org/archives/2023/01/communication-between-blood-and-brain-in-aging-and-rejuvenation/ As noted here, joining the circulatory systems of an old and young mouse results in some degree of rejuvenation in the old mouse. Where brain function is improved, researchers are inte...
Source: Fight Aging! - January 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senotherapeutics Will Reduce the Side-Effects of Cancer Radiotherapy
Treatment with radiation to kill cancerous cells results in an increased burden of senescent cells, both in and around the tumor. This is a fair trade-off; a senescent cancerous cell may be harmful in and of itself, but it is a good deal less harmful in the long run than an active cancer cell. Unfortunately senescent cells produce pro-growth, pro-inflammatory signaling that is disruptive of tissue function, raises the risk of suffering a range of age-related conditions, and increases the risk of both reoccurrence of the treated cancer and the development of later unrelated cancers. Thus given the work taking place o...
Source: Fight Aging! - January 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Calorie Restriction as an Adjuvant Cancer Treatment
Calorie restriction and intermittent fasting have been extensively studied in the context of aging, and most of the age-slowing interventions so far tested in animal studies are derived in some way from a knowledge of the stress response mechanisms triggered by a lowered calorie intake. The long term effects of calorie restriction and fasting in short-lived species are quite different from those in long-lived species: only the short-lived species exhibit a meaningful extension of life span, as much as 40% in mice. Yet the short-term effects on metabolism and cellular mechanisms are very similar. The beneficial response to ...
Source: Fight Aging! - April 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

PhD Student position at the BCBL- Basque Center on Cognition Brain and Language (San Sebasti án, Basque Country, Spain)
 PhD Student position at the BCBL- Basque Center on Cognition Brain and Language (San Sebasti án, Basque Country, Spain) www.bcbl.euINFORMATION ABOUT THE POSITION Position: PhD studentResearcher Profile: First Stage Researcher (R1- up to the point of PhD)Number of vacancies: 1Project: Spanish Ministry of Economy and Competitiveness through the Plan Nacional RTI2018 093547 B I00 (LANGCONN)Location:  Spain> Donostia-San SebastianResearch Field: Neuroscience> Cognition and LanguageType of contract/Duration of Contract : Temporary>  4 yearsJob Stat...
Source: Talking Brains - April 16, 2021 Category: Neuroscience Authors: Greg Hickok Source Type: blogs

Glioma diagnostics and research in JoVE
I recently received an email from Chun-Chieh (Paul) Lin and George Zanazzi at Dartmouth-Hitchcock Medical Center. They were invited as editors for a new Methods Collection in JoVE focusing on "Glioma diagnostics and research" . Dr. Lin and Zanazzi write: " We intend to highlight techniques used in the diagnostic classification of glial neoplasms and also in vivo or in vitro glioma research models. We welcome a variety of submissions covering these challenging but interesting neoplasms. " Please feel free to contact Paul (Chun-Chieh.Lin@hitchcock.org) and George (George.J.Zanazzi@hitchcock.org) for details!Dr. Paul LinDr. G...
Source: neuropathology blog - March 15, 2021 Category: Radiology Tags: neuropathologists Source Type: blogs

Diffuse Midline Glioma, H3 K27M Mutation
is not a phrase you want to hear from a doctor. It’s a type of tumour that most commonly affects people under about the age of 25 years but over 3 years. It’s very rare – 100 people in the UK annually – but always lethal, sadly. The tumour grows rapidly within the Central Nervous System and has a devastating effect on the spinal cord or the brain depending on precisely where it grows. I must admit I’d heard of spinal tumours, but don’t think I’d heard this full phrase until a friend posted about it on social media as their daughter had started a fundraiser to raise funds for rese...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 15, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs

Midline Glioma – research fundraiser
UPDATE: Since posting, the fundraiser has gone from 57% to 62% target reached! Thank you! Keep those donations coming in. Diffuse Midline Glioma, H3 K27M Mutation is not a phrase you want to hear from a doctor. It’s a type of tumour that most commonly affects people under about the age of 25 years but over 3 years. It’s very rare – 100 people in the UK annually – but always lethal, sadly. The tumour grows rapidly within the Central Nervous System and has a devastating effect on the spinal cord or the brain depending on precisely where it grows. I must admit I’d heard of spinal tumours, but do...
Source: David Bradley Sciencebase - Songs, Snaps, Science - December 15, 2020 Category: Science Authors: David Bradley Tags: Cancer Source Type: blogs

PhD Opportunities in San Sebastian, Spain--BCBL
The Spanish Ministry of Science, Innovation and Universities has published the call for PhD Students 2019. The application period is from 17/10/19 to 07/11/19 at 14:00h.The call offers:1 PHD STUDENT POSITION (4-YEAR CONTRACT)  TO JOIN PROJECT PGC2018-093408-B-I0- THALANG – FUNCTIONAL AND STRUCTURAL CONTRIBUTIONS OF THE HUMAN THALAMUS TO LANGUAGE SYSTEMS ACROSS DEVELOPMENT TO BE SUPERVISED BY PEDRO M. PAZ-ALONSOKey words: Thalamus, Language Systems, Reading, Vision, Functional Connectivity, Structural Connectivity, Lateral Geniculate Nucleus, Medial Geniculate Nucleus, PulvinarSummary of...
Source: Talking Brains - October 22, 2019 Category: Neuroscience Authors: Greg Hickok Source Type: blogs

New Biomaterial Improves Brain Cancer Survival in Rats
Researchers from the University of Nottingham have developed a new biomaterial that delivers chemotherapies to treat brain cancer. Their work demonstrates that their biodegradable paste led to increased survival compared to controls, and that half of all rats in a study were clear of any cancer as confirmed by laboratory tests. This exciting development may one day improve treatment options for glioblastoma patients, as well as those with other cancers. Surgery is commonly performed to try to fight glioblastoma. Yet, one of the major challenges is that despite careful surgical removal of the tumor, some cancer cells may...
Source: Medgadget - July 24, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Medicine Neurosurgery Oncology Source Type: blogs

Scorpion Protein Used to Help Visualize Brain Tumors
Clinicians at the Cedars-Sinai Medical Institute, along with scientists at Blaze Bioscience, Inc., have developed a new way to visualize brain tumors. The new imaging technique utilizes a special, high-sensitivity near-infrared camera developed at Cedars-Sinai, along with tozuleristide, or BLZ-100, the tumor-cell binding imaging agent developed by Blaze. The imaging agent contains a synthetic version of an amino acid compound found in scorpion venom. This combination can help clinicians visualize the boundaries between tumors and non-tumors more effectively, allowing them to remove tumor cells while sparing normal brain ti...
Source: Medgadget - May 13, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Materials Neurosurgery Pathology Source Type: blogs

Looking to the Future of Neuro Devices: Exclusive Interview with Alcyone Lifesciences CEO PJ Anand
Alcyone Lifesciences is a medical technology company based out of Lowell, MA, which specializes in central nervous system (CNS) drug delivery platforms for targeted infusions of the brain or spinal cord. Their Thecaflex DRx System was recently awarded Breakthrough Device designation by the FDA, for spinal infusion of therapeutic medications. Medgadget had the opportunity to speak with Alcyone Lifesciences CEO, PJ Anand, about his inspiration for cutting edge medical technology and the future direction of neurological devices.   Kurt Yaeger, Medgadget: Great to talk to you, PJ. Please first give us a sense of your back...
Source: Medgadget - May 7, 2019 Category: Medical Devices Authors: Kurt Yaeger Tags: Exclusive Neurology Neurosurgery Pain Management Psychiatry Source Type: blogs