[Research Article] Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas
Secretion of pleiotrophin by aggressive gliomas triggers the formation of abnormal blood vessels by endothelial cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - December 9, 2015 Category: Science Authors: Lei Zhang, Soumi Kundu, Tjerk Feenstra, Xiujuan Li, Chuan Jin, Liisi Laaniste, Tamador Elsir Abu El Hassan, K. Elisabet Ohlin, Di Yu, Tommie Olofsson, Anna-Karin Olsson, Fredrik Pontén, Peetra U. Magnusson, Karin Forsberg Nilsson, Magnus Essand, Anja Smi Source Type: news

[Editors' Choice] Repurposing drugs for glioblastoma
Antidepressants plus anticoagulants trigger self-destruction in glioma cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - November 4, 2015 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

DIPG: Searching for a Cure
NEW YORK. (Ivanhoe Newswire) -- Diffuse intrinsic pontine glioma or DIPG, is an invasive pediatric brain cancer…a tumor in the brain stem that is impossible to safely remove. Radiation and traditional chemotherapy may buy a patient some time, but ultimately, can’t save a child’s life. Luckily, researchers are testing a new way to deliver cancer-fighting drugs that may someday soon lead to a cure. (Source: Medical Headlines From Ivanhoe.com)
Source: Medical Headlines From Ivanhoe.com - November 3, 2015 Category: Consumer Health News Source Type: news

Histone deacetylase 6 inhibition enhances oncolytic viral therapy
(Journal of Clinical Investigation) A new study in the Journal of Clinical Investigation indicates that inhibition of histone deaceteylase 6 improves the ability of oncolytic herpes simplex virus type 1 to kill glioma cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 20, 2015 Category: Cancer & Oncology Source Type: news

Major study finds 5 new genetic variants linked to brain cancer
(Institute of Cancer Research) The biggest ever study of DNA from people with glioma -- the most common form of brain cancer -- has discovered five new genetic variants associated with the disease. Researchers said their findings provided important new evidence for an inherited susceptibility to glioma, and offered potential clues for how to treat or prevent the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 1, 2015 Category: Cancer & Oncology Source Type: news

The Peptide Microarray-Based Resonance Light Scattering Assay for Sensitively Detecting Intracellular Kinase Activity
The peptide microarray technology is a robust, reliable, and efficient technique for large-scale determination of enzyme activities, and high-throughput profiling of substrate/inhibitor specificities of enzymes. Here, the activities of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) in different cell lysates have been detected by a peptide microarray-based resonance light scattering (RLS) assay with gold nanoparticle (GNP) probes. Highly sensitive detection of PKA activity in 0.1 μg total cell proteins of SHG-44 (human glioma cell) cell lysate (corresponding to 200 cells) is achieved by a selected...
Source: Springer protocols feed by Immunology - September 29, 2015 Category: Allergy & Immunology Source Type: news

Triphase gets Health Canada nod to begin Phase I trial of marizomib to treat glioma
Drug development firm Triphase Accelerator has received approval from Health Canada to begin its Phase I trial of marizomib in combination with bevacizumab (Avastin) to treat patients with recurrent malignant glioma in Canada. (Source: Drug Development Technology)
Source: Drug Development Technology - September 28, 2015 Category: Pharmaceuticals Source Type: news

Daughter's tragedy that may lead to cure for a childhood killer
Parents raise money to find cure for rare form of childhood brain cancer (Source: Telegraph Health)
Source: Telegraph Health - September 27, 2015 Category: Consumer Health News Tags: cure Abbie's Army childhood no Diffuse Intrinsic Pontine Glioma (DIPG) cancer Source Type: news

Antidepressants plus blood-thinners slow down brain cancer
(Ecole Polytechnique Fédérale de Lausanne) Tricyclic antidepressants combined with anticoagulant drugs can slow down gliomas brain tumors by causing the cancer cells to eat themselves. The study is published in Cancer Cell. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2015 Category: Cancer & Oncology Source Type: news

Overweight and Lack of Exercise Linked to Meningioma Overweight and Lack of Exercise Linked to Meningioma
High body mass index and physical inactivity were linked to meningioma, but not glioma, in a new meta-analysis. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 22, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

This Type Of Brain Tumor Is More Likely To Strike Obese People
By: Christopher Wanjek Published: 09/18/2015 10:27 AM EDT on LiveScience Being obese may raise your risk of developing a type of brain tumor called a meningioma by more than 50 percent, according to a new study. The scientists said their study, a meta-analysis of 13 previous studies that included more than 6,000 people with brain tumors, does not prove that obesity causes brain tumors. But they say they have uncovered a striking correlation between an increased risk of brain tumor and body mass index. Overweight patients were 21 percent more likely to develop a meningioma tumor compared with normal-weight individuals, but ...
Source: Healthy Living - The Huffington Post - September 20, 2015 Category: Consumer Health News Source Type: news

Signs of Brain Tumor May Show in Blood Years Before Diagnosis
Glioma patients appear to have early immune response, study suggests (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - September 19, 2015 Category: Cancer & Oncology Source Type: news

Signs of Brain Tumor May Show in Blood Years Before Diagnosis
Glioma patients appear to have early immune response, study suggests (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 19, 2015 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Research, News, Source Type: news

Excess Fat Tied to Risk of Some Brain Cancers (CME/CE)
(MedPage Today) -- Meningioma, but not glioma, seen more commonly in the overweight (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - September 18, 2015 Category: Hematology Source Type: news

Signs of Brain Tumor May Show in Blood Years Before Diagnosis
Glioma patients appear to have early immune response, study suggests Source: HealthDay Related MedlinePlus Pages: Brain Tumors, Laboratory Tests (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - September 18, 2015 Category: Consumer Health News Source Type: news

Meningioma Risk May Be Associated with BMI, Physical Activity (FREE)
By Christine Sadlowski Edited by Susan Sadoughi, MD, and Richard Saitz, MD, MPH, FACP, FASAM High body-mass index and low physical activity were associated with increased likelihood of meningioma, but not glioma, in a meta-analysis published … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 17, 2015 Category: Primary Care Source Type: news

What a Cancer Patient's Hair Taught Me About Medicine
"Promise you won't be an ass." Sudesna, my classmate, first told me about Sarah Walsh over a dinner of Thai green curry. Sarah, a 23-year-old girl, was hospitalized due to worsening difficulty with swallowing and moving her fingers. Sudesna knew I'd be interested in Sarah's case, but feared my tactlessness. As a third year medical student, I had learned some of the science and ignored most of the art. "Fine...I'll try." When Sudesna and I visited Sarah the following morning, she was lounging in cozy-looking plaid PJs and glasses that reminded me of Liz Lemon from 30 Rock. I couldn't decide if her should...
Source: Healthy Living - The Huffington Post - September 10, 2015 Category: Consumer Health News Source Type: news

Child brain cancer charity receives £300,000 anonymous donation
The Glasgow-based organisation helps to treat children with diffuse intrinsic pontine glioma (DIPG) brain tumours (Source: Telegraph Health)
Source: Telegraph Health - September 7, 2015 Category: Consumer Health News Tags: Funding Neuro brain tumour steven gill child diffuse intrinsic pontine glioma cancer DIPG Source Type: news

Child brain cancer charity recieves £300,000 anonymous donation
The Glasgow-based organisation helps to treat children with diffuse intrinsic pontine glioma (DIPG) brain tumours (Source: Telegraph Health)
Source: Telegraph Health - September 7, 2015 Category: Consumer Health News Tags: Funding Neuro brain tumour steven gill child diffuse intrinsic pontine glioma cancer DIPG Source Type: news

Researchers develop a likely new combo treatment for the deadliest form of brain cancer
Scientists have developed a potentially promising new combination therapy for glioblastoma, the deadliest form of brain cancer. Glioblastoma, also known as grade IV glioma, is the most aggressive primary brain tumor in humans. Approximately 23,000 people in the U.S. are diagnosed with glioblastoma (GBM) every year. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 1, 2015 Category: Science Source Type: news

UCLA researchers create a promising new treatment for the deadliest form of brain cancer
UCLA scientists have developed a potentially promising new combination therapy for glioblastoma, the most common and deadliest form of brain cancer. Glioblastoma, also known as grade IV glioma, is an aggressive primary brain tumor in humans. Approximately 23,000 people in the U.S. are diagnosed with glioblastoma every year. Patients usually receive surgery, chemotherapy and radiation, but these treatments are not very effective as an estimated 50 percent of GBM patients die within one year, and 90 percent die within three years. A study led by Dr. Robert Prins and Dr. Linda Liau, both members of the UCLA Jonsson Comprehens...
Source: UCLA Newsroom: Health Sciences - September 1, 2015 Category: Universities & Medical Training Source Type: news

Impact of Molecular Pathology on Classifying Diffuse GliomasImpact of Molecular Pathology on Classifying Diffuse Gliomas
Learn how molecular pathology has improved pricision in defing and grouping gliomas. Cancer Control: Journal of the Moffitt Cancer Center (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 28, 2015 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Survival Varies by Sex in Pediatric High-Grade Glioma Survival Varies by Sex in Pediatric High-Grade Glioma
New research shows a greater survival benefit for girls who had total resection of their tumor compared with boys who underwent the same procedure. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 25, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Clinical Trials OK for High-Grade Glioma Patients (CME/CE)
(MedPage Today) -- Automatic exclusions are unjustified, review concludes (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - August 22, 2015 Category: Hematology Source Type: news

Complete resection of high-grade brain cancer yields better survival in children -- especially girls
(Wolters Kluwer Health) For children with aggressive brain cancers called high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer, reports a study in the September issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The journal is published by Wolters Kluwer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 18, 2015 Category: Global & Universal Source Type: news

Brain Tumors vs. California Stem Cell Program: Disease-a-Week Challenge #8
When Vice President Joe Biden stood beside the coffin of his son Beau, it seemed the whole world took a breath. Every parent knew what he must be feeling: one of the most powerful men on Earth, and yet he could not save his son. Beau Biden was diagnosed with a malignant brain cancer, possibly a glioma: the same malady which took the lives of Ted Kennedy, Gene Siskel, Susan Hayward, George Gershwin and too many others. Brain cancers like Beau Biden's kill about 15,000 adults each year. This is a deadly condition. Even with the best treatment available--surgery, radiation, chemotherapy--survival averages only about 15 month...
Source: Science - The Huffington Post - July 17, 2015 Category: Science Source Type: news

New classification system for brain tumors
Despite modern chemoradiation therapy it is still very difficult to give reliable prognoses for malignant gliomas. Surgical removal of the glioma is still the preferred method of treatment. Doctors have now developed a new procedure for analyzing radiological imaging scans which makes it possible to predict the course of a disease relatively precisely. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 14, 2015 Category: Science Source Type: news

New classification system for brain tumors
(University of Erlangen-Nuremberg) Despite modern chemoradiation therapy it is still very difficult to give reliable prognoses for malignant gliomas. Surgical removal of the glioma is still the preferred method of treatment. Doctors at Universitätsklinikum Erlangen's Department of Neurosurgery have now developed a new procedure for analyzing radiological imaging scans which makes it possible to predict the course of a disease relatively precisely. Their findings have now been published in the journal Scientific Reports. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 14, 2015 Category: Cancer & Oncology Source Type: news

Gene therapy advance thwarts brain cancer in rats
A nanoparticle gene delivery system has been developed by scientists that destroys brain gliomas in a rat model, significantly extending the lives of the treated animals. The nanoparticles are filled with genes for an enzyme that converts a prodrug called ganciclovir into a potent destroyer of the glioma cells. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - July 11, 2015 Category: Science Source Type: news

Adult Glioma Survival Improved Significantly in Past DecadeAdult Glioma Survival Improved Significantly in Past Decade
Survival for adult gliomas improved significantly over the last decade in the US point to improvements in neuro-oncology standard of care. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Improved survival in adult patients with low-grade brain tumors
(University of California - San Diego) Using clinical data collected over the past decade through a US cancer registry, researchers at the University of California, San Diego School of Medicine demonstrated that significant strides have been made in improving the survival of adult patients with low-grade gliomas, a slow-growing yet deadly form of primary brain cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 1, 2015 Category: Cancer & Oncology Source Type: news

New Ways to Evaluate Gliomas Will Enhance Practice New Ways to Evaluate Gliomas Will Enhance Practice
Genetic sequencing can identify tumor groupings that seem to share closer prognostic and clinical features than those defined by histopathological evaluation. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 25, 2015 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Study discovers new method of classifying low-grade brain tumors
(University Hospitals Case Medical Center) Scientists and physicians from federally designated cancer centers used molecular and genetic analysis to develop a new method of classifying brain tumors known as low and intermediate grade gliomas. The approach reduces the role of individual observers' assessments of the tumors' appearance. This should improve diagnosis and treatment, and identifies biological targets for future therapies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 10, 2015 Category: Biology Source Type: news

Molecular classification may improve method physicians use to diagnose and treat gliomas
(Mayo Clinic) The molecular makeup of brain tumors can be used to sort patients with gliomas into five categories, each with different clinical features and outcomes, researchers at Mayo Clinic and the University of California San Francisco have shown. The finding could change the methods that physicians rely on to determine prognosis and treatment options. Previously, they relied on how patients' tumors look under the microscope. The study is published online in the New England Journal of Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2015 Category: Cancer & Oncology Source Type: news

Genetic markers provide better brain cancer classification
(University of California - San Francisco) A team of scientists from UC San Francisco and Mayo Clinic has shown that using just three molecular markers will help clinicians classify gliomas -- the most common type of malignant brain tumors -- more accurately than current methods. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2015 Category: Cancer & Oncology Source Type: news

Researchers take a major step in reclassifying brain tumors with precision
(Emory Health Sciences) A Cancer Genome Atlas study on diffuse gliomas finds genomic analysis predicts tumor behavior better than microscope appearance (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 10, 2015 Category: Cancer & Oncology Source Type: news

Researchers develop models for targeted cancer therapy
The results of a recent study on targeted therapy of a specific type of brain cancer show specific progress in cancer treatment. Diffuse intrinsic pontine glioma may be one of the lesser-known forms of cancer, yet may be one of the most diabolical. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 8, 2015 Category: Science Source Type: news

Molecular Classification May Improve Method Used to Diagnose and Treat Gliomas
ROCHESTER, Minn. — The molecular makeup of brain tumors can be used to sort patients with gliomas into five categories, each with different clinical features and outcomes, researchers at Mayo Clinic and the University of California San Francisco have shown. The finding could change the methods that physicians rely on to determine prognosis and treatment [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - June 8, 2015 Category: Databases & Libraries Source Type: news

Implantable micro-device to monitor oxygen in glioma to improve treatment outcomes
Monitoring oxygen levels in human tumors growing in a mouse brain using EPR oximetry with implantable resonators provides opportunities to evaluate and optimize various strategies being developed to improve oxygen levels in the glioma. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 21, 2015 Category: Science Source Type: news

[Editors' Choice] Neurons promote glioma growth
Active neurons release neuroligin-3, which stimulates glioma proliferation. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - May 20, 2015 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

ALA Fluorescence Intensifies With Glioma Tumor CellularityALA Fluorescence Intensifies With Glioma Tumor Cellularity
ALA (5-aminolevulinic acid) shows a high positive predictive value for high-grade gliomas, but the test shows poor probability for absence of tumor cells. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 13, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Study points to possible treatment for lethal pediatric brain cancer
(NIH/National Institute of Neurological Disorders and Stroke) Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas, an aggressive and lethal form of pediatric cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 4, 2015 Category: Cancer & Oncology Source Type: news

Study points to possible treatment for lethal pediatric brain cancer
Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer. (Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke)
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - May 4, 2015 Category: Neurology Source Type: news

Thinking Can Fuel The Growth Of Brain Tumors, Study Finds
Thinking helps fuel the growth of deadly brain tumors, according to a surprising new study from Stanford University School of Medicine. The study, which was recently published in the journal Cell, found that tumors actually use nerve activity in the cerebral cortex -- i.e., thinking -- to promote their own growth. The researchers observed high-grade gliomas, a deadly form of tumor that starts in the brain or spinal cord, and makes up roughly 80 percent of malignant brain tumors. Currently, treatment options for high-grade gliomas are very limited. "Understanding that brain activity fuels glioma growth opens new ...
Source: Science - The Huffington Post - April 27, 2015 Category: Science Source Type: news

Thoughts Can Fuel Some Deadly Brain Cancers
A doctor-scientist's long quest to help children with a rare form of brain cancer has led to the discovery that high levels of brain activity can make glioma tumors grow faster.» E-Mail This (Source: NPR Health and Science)
Source: NPR Health and Science - April 23, 2015 Category: Consumer Health News Authors: Jon Hamilton Source Type: news

Brain tumor growth stimulated by nerve activity in the cortex, Stanford study finds
(Stanford University Medical Center) Deadly brain tumors called high-grade gliomas grow with the help of nerve activity in the cerebral cortex, according to a new study by researchers at the Stanford University School of Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 23, 2015 Category: Cancer & Oncology Source Type: news

Cancer Research Progress Spotlights Cruel Irony
To hear the words "cancer" and "cure" in the same sentence from experienced cancer researchers is both breathtaking and unexpected. Researchers and top oncologists are usually cautious to a fault. To hear that Congress is again trying to squeeze cancer research budgets is breathtaking but predictable. They've become frugal, also to a fault. Such is the cruel irony facing cancer patients and researchers today. Building on over 50 years of scientific progress, research leaders from cancer centers across the country are achieving stunning results that have led even the most guarded of them to use such ...
Source: Healthy Living - The Huffington Post - April 8, 2015 Category: Consumer Health News Source Type: news

'Sophisticated Evaluation of Serious Research' at the New York Times?
On March 19, Nick Bilton, technology columnist at The New York Times, wrote an article in the newspaper entitled "New Gadgets, New Health Worries." Approximately half of the piece was about the possible health hazards posed by the new Apple Watch and other smart watches; the other half concerned the health hazards associated with the use of cellphones. "We have long suspected that cellphones, which give off low levels of radiation, could lead to brain tumors, cancer, disturbed blood rhythms, and other health problems if held too close to the body for extended periods," Bilton wrote. Later in his column...
Source: Science - The Huffington Post - March 28, 2015 Category: Science Source Type: news

Together, nanotechnology, genetic interference may tackle 'untreatable/ brain tumors
There are no effective available treatments for sufferers of Glioblastoma multiforme, the most aggressive and devastating form of brain tumor. Now a study may offer hope to the tens of thousands diagnosed with gliomas every year, using a nanomedical treatment first engineered to tackle ovarian cancer tumors. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 24, 2015 Category: Science Source Type: news

Together, nanotechnology and genetic interference may tackle 'untreatable' brain tumors
(American Friends of Tel Aviv University) There are no effective available treatments for sufferers of Glioblastoma multiforme, the most aggressive and devastating form of brain tumor. Now a new Tel Aviv University study may offer hope to the tens of thousands diagnosed with gliomas every year, using a nanomedical treatment first engineered to tackle ovarian cancer tumors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 24, 2015 Category: Global & Universal Source Type: news