Mouse study shows how advancing glioma cells scramble brain function, blood flow
(The Zuckerman Institute at Columbia University) The first sign of trouble for a patient with a growing brain tumor is often a seizure. Such seizures have long been considered a side effect of the tumor. But now a joint team of Columbia engineers and cancer researchers studying brain tumors has found evidence that the seizures caused by an enlarging tumor could spur its deadly progression. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 14, 2020 Category: Biology Source Type: news
New findings shed light on selective therapeutics for IDH1-mutated glioma
(Chinese Academy of Sciences Headquarters) Findings of a new study led by Prof. XU Guowang from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences and Prof. YANG Chunzhang from the National Cancer Institute shed light on the selective therapeutics for IDH1-mutated glioma by targeting glutathione synthesis pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2020 Category: Cancer & Oncology Source Type: news
Virginia Tech scientists reveal brain tumors impact normally helpful cells
(Virginia Tech) Unprovoked recurrent seizures are a serious problem affecting most patients who suffer from glioma, a primary brain tumor composed of malignant glial cells. Fralin Biomedical Research Institute researchers tested the hypothesis that glioma-induces processes that renders a type of brain cells dysfunctional, perpetuating the imbalance between excitation and inhibition in tumor-associated epilepsy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 6, 2020 Category: International Medicine & Public Health Source Type: news
Babies with brain tumors could benefit from targeted treatment
(Institute of Cancer Research) Brain cancer in infants is biologically distinct from other childhood brain tumors and could be successfully treated with targeted drugs, a new study has shown. In the largest and most comprehensive study of infant gliomas to date, scientists found that these tumors are molecularly different from those in older children, helping explain why they tend to be less aggressive. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2020 Category: Cancer & Oncology Source Type: news
Good news for NF patients with low grade glioma (LGG)
(Children's Tumor Foundation) A paper published in the academic journal Neuro-Oncology by NF experts has demonstrated an increased understanding of low grade gliomas (LGG) occurring in children and adults with NF1. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 31, 2020 Category: Biology Source Type: news
Combination drug therapy for childhood brain tumors shows promise in laboratory models
(Johns Hopkins Medicine) In experiments with human cells and mice, researchers at the Johns Hopkins Kimmel Cancer Center report evidence that combining the experimental cancer medication TAK228 (also called sapanisertib) with an existing anti-cancer drug called trametinib may be more effective than either drug alone in decreasing the growth of pediatric low-grade gliomas. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 17, 2020 Category: International Medicine & Public Health Source Type: news
Glioma Trials Should Track Living Well, Not Just Longer Glioma Trials Should Track Living Well, Not Just Longer
Neuro-oncology working group backs focus on how patients feel, function.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 11, 2020 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
Finding a cure for Fido's brain cancer may help us find a cure for ourselves
(Jackson Laboratory) For cancers such as glioma, preclinical research models have failed to provide sufficient insight for medical progress. A team led by Jackson Laboratory's Roel Verhaak thoroughly analyzed sporadic canine gliomas and found that their molecular characteristics, including gene mutations and duplications, resemble those of humans. The results indicate that dogs provide an effective model for human gliomas, and learning how to more effectively treat our pets will likely inform better prognoses for human patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news
Poliovirus therapy shows potential as cancer vaccine in lab studies
A modified form of poliovirus, pioneered at Duke Cancer Institute as a therapy for glioblastoma brain tumors, appears in laboratory studies to also have applicability for pediatric brain tumors when used as part of a cancer vaccine. In preclinical studies using mice and human cancer cells, an injection of the modified poliovirus vector instigated an immune response that homed in on mutated cancer cells that predominate in diffuse midline glioma (DMG) tumors. The cancer strikes children and is universally deadly. (Source: World Pharma News)
Source: World Pharma News - January 30, 2020 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
Brain tumors remodel neuronal synapses to promote growth
(Baylor College of Medicine) Scientists discovered that glioma, a lethal form of brain cancer, alters the activity of neighboring neurons, accelerating a vicious cycle that drives tumor-associated epilepsy and tumor progression. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 29, 2020 Category: Cancer & Oncology Source Type: news
Study uncovers unexpected connection between gliomas, neurodegenerative diseases
(Michigan Medicine - University of Michigan) New basic science and clinical research identifies TAU, the same protein studied in the development of Alzheimer's, as a biomarker for glioma development. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 22, 2020 Category: Cancer & Oncology Source Type: news
Surgery May Add Years for Patients With Deadly Brain Cancer: Study
WEDNESDAY, Jan. 20, 2020 -- Surgical removal of the entire tumor may extend the lives of patients with a rare and deadly type of brain cancer called brainstem high-grade gliomas, a new study suggests.
Researchers analyzed data from 103 patients in... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - January 15, 2020 Category: General Medicine Source Type: news
Peering into the genome of brain tumor
(Osaka University) Scientists at Osaka University have created a machine learning method for classifying the mutations of glioma brain tumors based on MR images alone. Thus far, classification has only been possible by tissue sampling during surgery. The new method is noninvasive, may remove the need for a tissue sample and help accelerate delivery of treatment for patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 9, 2020 Category: Cancer & Oncology Source Type: news
Connecticut boy, seven, with fatal brain tumor spends last Christmas home
Trenton O'Brien, seven, of East Haven, Connecticut, was diagnosed with a brain tumor called Diffuse Intrinsic Pontine Glioma in June 2019. He's been home, in hospice care, since Christmas Eve. (Source: the Mail online | Health)
Source: the Mail online | Health - January 6, 2020 Category: Consumer Health News Source Type: news
New Mom With Brain Tumor Turns To Boston Hospital For Keyhole Brain Surgery
BOSTON (CBS) — Imagine giving birth to a premature baby and then being told you have a brain tumor. That’s what happened to a woman from Holden. But thanks to a new approach at Brigham and Women’s Hospital, this new mom was able to have brain surgery and quickly return to her newborn son.
At 27 weeks pregnant, Bethany Shea was diagnosed with preeclampsia and had an emergency C-section. Then she went blind.
“It was a pregnancy complication due to my high blood pressure,” Bethany explained.
Bethany regained her vision, but worried she had had a stroke, doctors ordered an MRI. But instead of a stroke, it reveale...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 30, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Brigham and Women's Hospital Dr. Mallika Marshall Source Type: news
