Immunotherapy alone extended life for metastatic lung cancer patients with KRAS mutation
(University of Pennsylvania School of Medicine) Real-word evidence is suggesting, for the first time, the most beneficial treatment courses that could help extend the lives of patients with metastatic non-small cell lung cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2021 Category: Cancer & Oncology Source Type: news

Lung cancer screening predicts risk of death from heart disease
(Radiological Society of North America) A deep learning algorithm accurately predicts the risk of death from cardiovascular disease using information from low-dose CT exams performed for lung cancer screening, according to a new study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2021 Category: Cancer & Oncology Source Type: news

Potential ways to improve survival for cancer patients who receive fragmented care
(American College of Surgeons) New research reveals that 28 percent of patients who are readmitted to the hospital with complications after surgical removal of pancreatic, liver, or stomach cancer go to a different hospital for follow-up care. This fragmentation of health care is associated with a 50 percent increased odds of dying, according to a study published online by the Journal of the American College of Surgeons ahead of print. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2021 Category: Cancer & Oncology Source Type: news

McMaster scientists discover trained immune cells are highly effective against cancer
(McMaster University) McMaster University researchers Ali Ashkar and Sophie Poznanski have uncovered that changing the metabolism of natural killer (NK) immune cells allows these cells to overcome the hostile conditions found inside tumours and destroy advanced ovarian and lung cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2021 Category: Cancer & Oncology Source Type: news

Cellular " hotspots " in the brain may signify the earliest signs of cancer
(King's College London) Researchers at King's College London Institute of Psychiatry, Psychology,& Neuroscience, in collaboration with King's College Hospital NHS Foundation Trust, have found small clusters of cells in the brain that identify locations where tumours could become malignant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

DDT exposure in grandmothers linked to obesity, earlier periods in granddaughters
(Public Health Institute) In the first study showing health effects from a toxic environmental chemical over three generations of people, researchers from the Public Health Institute's Child Health and Development Studies (CHDS) program found that young women today may face increased health risks linked to breast cancer due to their grandmothers' exposure to the banned pesticide DDT. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Researchers establish intracellular interaction network in breast cancer
(National Research University Higher School of Economics) Researchers at HSE University have identified the genes that play a crucial role in breast cancer metastasis. The results of the study were published in the journal PLOS ONE (https://doi.org/10.1371/journal.pone.0249424). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Protein can release trapped histones in the cell
(University of Copenhagen - The Faculty of Health and Medical Sciences) The heat-shock protein DNAJC9 has a surprising dual histone chaperone functionality a new study in Molecular Cell shows. The protein is the first shown to actively release histones that are trapped in non-specific interactions with DNA, directing them back to their job of organizing chromatin in the cell. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

MD Anderson and Boehringer Ingelheim expand collaboration to accelerate development of KRAS and TRAILR2 compounds in lung cancer
(University of Texas M. D. Anderson Cancer Center) MD Anderson and Boehringer Ingelheim have expanded their joint Virtual Research and Development Center to accelerate the development of new targeted therapies against KRAS and TRAILR2 in lung cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Triple combination therapy shows promise against a rare deadly asbestos cancer
(University Health Network) Combining immune-boosting drugs with radiation and surgery increased the survival and anticancer immune response in mouse models of mesothelioma in preclinical research by Princess Margaret Cancer Centre researchers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Australian researchers find new way to target deadly childhood cancer
(Children's Cancer Institute Australia) Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Increased risk of liver cancer in patients with non-alcoholic fatty liver
(Karolinska Institutet) Non-alcoholic fatty liver, NAFLD, is associated with several health risks. According to a new registry study led by researchers at Karolinska Institutet in Sweden, NAFLD is linked to a 17-fold increased risk of liver cancer. The findings, published in Hepatology, underscore the need for improved follow-up of NAFLD patients with the goal of reducing the risk of cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Innovative technique developed to destroy cancerous kidney cells
(University of Surrey) An innovative new technique that encourages cancer cells in the kidneys to self-destruct could revolutionise the treatment of the disease, a new study in the journal Pharmaceutics reports. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Diabetes drug shows potential in fighting cancer
(Massachusetts General Hospital) Phenformin, in combination with immunotherapies like PD-1 immune checkpoint inhibitors, shows greater promise than phenformin or metformin alone. A clinical trial is under way at MGH to evaluate the use of phenformin with an inhibitor of the BRAF-mutated gene, present in roughly half of all melanomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Protein found to control drivers of normal growth and cancer
(NYU Langone Health / NYU Grossman School of Medicine) Researchers have found a long-sought enzyme that prevents cancer by enabling the breakdown of proteins that drive cell growth, and that causes cancer when disabled. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Telling sunbathers what they don't want to hear: Tanning is bad
(Ohio State University) Most young women already know that tanning is dangerous and sunbathe anyway, so a campaign informing them of the risk should take into account their potential resistance to the message, according to a new study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Scientists identify potential drug candidates for deadly pediatric leukemia
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two existing drug candidates--JAK inhibitors and Mepron--hold potential as treatments for a deadly acute myeloid leukemia (AML) subtype that is more common in children. The foundational study, published in the journal Blood, is a first step toward finding effective treatments for the hard-to-treat blood cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

How transcription factors work together in cancer formation
(University of Colorado Anschutz Medical Campus) A new study co-authored by University of Colorado Cancer Center researcher Srinivas Ramachandran, PhD, shows how enhancers function in cells. Enhancers are DNA sequences that drive gene expression, developmental transitions, and cellular responses to external stimuli. They have multiple binding sites for transcription factors. Ramachandran wanted to find out what the role of those multiple binding sites was, and if transcription factors were binding to the multiple enhancer sites randomly or in a coordinated fashion. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Alliance for Cancer Gene Therapy Summit 2021 features world renowned cancer researchers advancing so
(Alliance for Cancer Gene Therapy) James P. Allison, PhD, Carl H. June, MD and Siddhartha Mukherjee, MD Keynote April 29 Summit on Advancing Solid Tumor Breakthroughs: Eight additional panels on developing the next generation cancer cell and gene therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Dannielle Engle awarded prestigious pancreatic cancer research grant
(Salk Institute) Salk Assistant Professor Dannielle Engle was selected as the first recipient of the Lustgarten Foundation-AACR Career Development Award for Pancreatic Cancer Research in Honor of Ruth Bader Ginsburg, the late Supreme Court Justice and women's rights pioneer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 14, 2021 Category: Cancer & Oncology Source Type: news

Inflammation a key to targeting pregnancy-associated breast cancer
(Garvan Institute of Medical Research) Targeting the tumour environment may help improve treatments for breast cancers affecting pregnant women and young mothers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

First patient-derived organoid model for cervical cancer
(Hubrecht Institute) Researchers from the group of Hans Clevers developed the first patient-derived organoid model for cervical cancer. They also modelled the healthy human cervix using organoids. The researchers used the platform to study sexually transmitted infections for a herpes virus. The model can potentially also be used to study human papillomavirus (HPV), which is one of the main causes of cervical cancer. The results will be published in Cell Stem Cell on the 13th of April, 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Aged bone marrow niche impedes function of rejuvenated hematopoietic stem cells
(AlphaMed Press) A new study released in STEM CELLS focuses on rejuvenating hematopoietic stem cells as a way to treat leukemia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

DNA structure itself is involved in genome regulation
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) When genes must be accessed for transcription, the DNA double helix unwinds and the strands separate from each other so that all the elements needed for gene expression can access. This process results in the accumulation of DNA supercoiling that needs to be resolved. A study published in Cell Reports reveals that DNA supercoiling is involved in regulating gene expression rather than just being collateral damage that must be fixed, as was previously believed. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

UK cancer patients more likely to die following COVID-19 than European cancer patients
(Imperial College London) Cancer patients from the UK were 1.5 times more likely to die following a diagnosis with COVID-19 than cancer patients from European countries. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Study suggests common drug could be used to prevent certain skin cancers
(Ohio State University Wexner Medical Center) New data published by researchers at The OSUCCC - James suggests that an oral drug currently used in the clinical setting to treat neuromuscular diseases could also help prevent a common form of skin cancer caused by damage from ultraviolet-B radiation from the sun. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

JNCCN Study: Important potential role for routine brain imaging in advanced kidney cancer
(National Comprehensive Cancer Network) The April 2021 issue of JNCCN--Journal of the National Comprehensive Cancer Network publishes new research from Memorial Sloan Kettering Cancer Center (MSK) and Gustave Roussy Institute, which suggests that baseline brain imaging should be considered in most patients with metastatic kidney cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Closer to human -- Mouse model more accurately reproduces fatty liver disease
(Baylor College of Medicine) Researchers have developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 13, 2021 Category: Cancer & Oncology Source Type: news

Researchers identify surface protein as a new osteosarcoma therapeutic target for antibody-drug conjugates
(University of Texas M. D. Anderson Cancer Center) A preclinical study shows an antibody-drug conjugate (ADC) targeting surface protein MT1-MMP can act as a guided missile in eradicating osteosarcoma tumor cells without damaging normal tissues. This technology, using precision therapy targeting of cell-surface proteins through a Bicycle toxin conjugate (BTC), shows encouraging results for the treatment of osteosarcoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Estimation of colorectal cancer screening, outcomes during COVID-19 pandemic
(JAMA Network) What The Study Did:   This modeling study estimates COVID-19-related changes in rates of colorectal cancer screenings and associated outcomes and estimates the degree to which expanded fecal immunochemical testing could potentially mitigate these outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Cancer DNA blood tests validated by international research team
(Garvan Institute of Medical Research) Researchers have independently validated industry-leading blood tests that can detect the DNA released by tumours. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Better treatment for aggressive prostate cancer
(University of Colorado Anschutz Medical Campus) Published this week in the journal Molecular Cancer Research, Cramer's study specifically looks at how the loss of two specific prostate tumor-suppressing genes -- MAP3K7 and CHD1 --increases androgen receptor signaling and makes the patient more resistant to the anti-androgen therapy that is typically administered to reduce testosterone levels in prostate cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Drug testing approach uncovers effective combination for treating small cell lung cancer
(NIH/National Center for Advancing Translational Sciences (NCATS)) NIH researchers have identified and tested a drug combination that exploits a weakness in small cell lung cancer, an aggressive cancer. They targeted a vulnerability in cancer cell reproduction, increasing replication stress ¬ ¬ -- a hallmark of out-of-control cell growth in many cancers that damages DNA and forces cancer cells to constantly repair themselves. In a small trial, the drug duo shrank tumors in SCLC patients. The team's findings appear April 12 in Cancer Cell. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

E-cigarettes with a cigarette-like level of nicotine are effective in reducing smoking
(Virginia Commonwealth University) E-cigarettes that deliver a cigarette-like amount of nicotine are associated with reduced smoking and reduced exposure to the major tobacco-related pulmonary carcinogen, NNAL, even with concurrent smoking, according to a new study led by researchers at Virginia Commonwealth University and Penn State College of Medicine in Hershey, Pennsylvania (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Weight linked to risk of second cancer after breast cancer
(Kaiser Permanente) Breast cancer survivors who are overweight have a statistically significant increased risk of developing second primary cancers, according to results from a study conducted by Kaiser Permanente researchers and published in the Journal of the National Cancer Institute. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Study finds medical financial hardship common in adult survivors of AYA cancers
(American Cancer Society) New study finds higher medical financial hardship in adult survivors of adolescent and young adult (AYA) cancers than in adults without a history of cancer in the United States. The study appears in JNCI: The Journal of the National Cancer Institute. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

A tummy invader: This bacterial molecule may be key to fighting stomach cancer
(Osaka University) Researchers from Osaka University found thatH. pylori bacterial strains with low expression of a small RNA molecule called HPnc4160 are more likely to adapt to living in the human stomach. Gastric cancer patients have lower levels of HPnc4160, as well as higher levels of pathogenic bacterial proteins, than individuals without cancer. This work provides crucial knowledge for the development of new treatments for chronicH. pylori infections and gastric cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Study reveals cancer immunotherapy patients at most risk of life-threatening side effects
(Massachusetts General Hospital) Immune checkpoint inhibitors boost a patient's immune response against cancer cells, but they can cause potentially life-threatening side effects in some individuals. New research may help clinicians determine which patients are most at risk. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Study reveals crucial details on skin-related side effects of cancer immune therapies
(Massachusetts General Hospital) Immune checkpoint inhibitors are life-saving therapies against advanced cancer, but they can cause side effects, most commonly involving the skin. New research provides insights on the extent of these side effects, when they tend to arise, and which patients may be most at risk of experiencing them. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Study shows tanning bed ban would reduce skin cancer rates in minors and cut healthcare costs
(Wiley) A recent study indicates that a US ban on the use of tanning beds among minors would prevent thousands of cases of melanoma in adolescents and would save millions of dollars in healthcare costs. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

CNIO scientists discovers a combination therapy for aggressive brain tumors
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) * The researchers conducted an in-depth study of resistance to temozolomide, the first-line treatment for glioblastoma, to which many patients cease to respond over time* The combination of temozolomide and dianhydrogalactitol acts synergistically, overcomes this resistance and increases survival in mice with brain tumours* Treatments for glioblastoma have not improved in the last 20 years. The authors argue for the need to translate these results into clinical trials to study whether this combination therapy is also effective in patients with this disease (S...
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Researchers discover new way to starve brain tumours
(Queen Mary University of London) Scientists from Queen Mary University of London, funded by the charity Brain Tumour Research, have found a new way to starve cancerous brain tumour cells of energy in order to prevent further growth. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 12, 2021 Category: Cancer & Oncology Source Type: news

Study provides new insights into resistance to immune checkpoint inhibitors
(Yale University) New research by Yale Cancer Center shows insights into modeling resistance to immune checkpoint inhibitors, a form of cancer immunotherapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

Activating the brain's immune system against cancer prevents it from spreading
(Tel-Aviv University) The researchers identified a failure in the brain's immune system, leading to the amplification of cell division and spread of Glioblastoma cancer cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

Study shows young early-onset colorectal cancer patients have increased survival
(Yale University) New research by Yale Cancer Center shows patients with early-onset colorectal cancer, age 50 and younger, have a better survival rate than patients diagnosed with the disease later in life. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

Yale Cancer Center study shows novel immunotherapy approach to fight melanoma
(Yale University) In a new study led by Yale Cancer Center, researchers have advanced a tumor-targeting and cell penetrating antibody that can deliver payloads to stimulate an immune response to help treat melanoma. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

MD Anderson researchers highlight advances in clinical studies at the AACR Annual Meeting 2021
(University of Texas M. D. Anderson Cancer Center) Researchers at The University of Texas MD Anderson Cancer Center conducted early phase clinical trials that showed promising results for patients with RET fusion-positive cancers, high-grade and low-grade glioma and ovarian cancer. The results for these studies will be presented at the AACR Annual Meeting 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

New CAR T approach minimizes resistance, helps avoid relapse in non-Hodgkin's B-cell lymphoma
(University of California - Los Angeles Health Sciences) Early results from a new, pioneering chimeric antigen receptor (CAR) T cell immunotherapy trial led by researchers at the UCLA found using a bilateral attack achieves a more robust defense and helps avoid relapse. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2021 Category: Cancer & Oncology Source Type: news

Personalized cancer vaccine is safe, shows potential benefit against cancer
(The Mount Sinai Hospital / Mount Sinai School of Medicine) A personalized cancer vaccine developed with the help of a Mount Sinai computational platform raised no safety concerns and showed potential benefit in patients with different cancers, including lung and bladder, that have a high risk of recurrence, according to results from an investigator-initiated phase I clinical trial presented during the virtual American Association for Cancer Research (AACR) Annual Meeting 2021, held April 10-15. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2021 Category: Cancer & Oncology Source Type: news

Mutant KRAS and p53 cooperate to drive pancreatic cancer metastasis
(University of Texas M. D. Anderson Cancer Center) MD Anderson researchers have discovered that mutant KRAS and p53, the most frequently mutated genes in pancreatic cancer, interact to promote metastasis and tumor growth. The findings point to a new therapeutic target for this deadly cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2021 Category: Cancer & Oncology Source Type: news