GI societies issue updated colorectal cancer screening recommendations
(American Gastroenterological Association) These evidence-based recommendations support closer follow-up after colonoscopy screenings for some groups, less intense follow-up for others, and provide guidance for removing colorectal polyps. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 18, 2020 Category: Cancer & Oncology Source Type: news

NUS researchers identify novel protein to prevent neuropathy from chemotherapy
(National University of Singapore, Yong Loo Lin School of Medicine) A team of researchers from the NUS Yong Loo Lin School of Medicine has identified a novel protein that would prevent the development of neuropathy, a major side effect of chemotherapy, in cancer patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

New computational tools identify alternative splicing changes in aggressive cancers
(Children's Hospital of Philadelphia) A multi-institutional group of researchers led by Children's Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at the University of California, Los Angeles (UCLA), was published today in the Proceedings of the National Academy of Sciences. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

Intratumoral heterogeneity may be responsible for chemotherapy resistance in patients with small cell lung cancer
(University of Texas M. D. Anderson Cancer Center) A study at The University of Texas MD Anderson Cancer Center found that chemotherapy results in increased heterogeneity within small cell lung cancer, leading to the evolution of multiple resistance mechanisms. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

Study identifies states with highest rates of melanoma due to ultraviolet radiation
(American Cancer Society) A new study finds a wide state-by-state variation in rates of melanoma caused by ultraviolet (UV) exposure with highest rates in several states on the East and West Coast including Hawaii, but also a few landlocked states, including Utah, Vermont, and Minnesota. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

Test measures immune response to improve ovarian cancer diagnosis
(RMIT University) About 300,000 new cases of ovarian cancer are diagnosed globally each year, with about 60% of women dying within five years after diagnosis. A clinical trial has shown testing for a specific immune biomarker could improve diagnosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 17, 2020 Category: Cancer & Oncology Source Type: news

The Lancet Oncology: Young cancer survivors face higher risk of severe health problems in later life than the general population, study suggests
(The Lancet) Cancer survivors who are diagnosed during adolescence or early adulthood (age 15-20 years) are at increased risk of premature death compared to the general population. They have an elevated risk of severe or life-threatening conditions compared to a sibling control group, according to an observational study of more than 10,000 cancer patients from 27 academic institutions in the USA and Canada, published in The Lancet Oncology journal on International Childhood Cancer Day (15 February). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

Scientists have identified protein involved in progression of lung cancer and melanoma
(Far Eastern Federal University) Scientists from Far Eastern Federal University (FEFU, Russia), University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression. During the research, the artificially gained WDR74 function brought about a high activity in cancer cells. However, when the function had been dropped cells failed to metastasize becoming more vulnerable to chemotherapy. Related articles are published in Cancer Letters and Oncogene. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

CDI laboratory explores pathway to open up blood cancer treatments
(Hackensack Meridian Health) The CDI team's findings could ultimately improve cancer treatments for people of advanced age, like that of adult acute myeloid leukemia (AML). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

New CRISPR-based tool can probe and control several genetic circuits at once
(Stanford School of Engineering) Stanford researchers have devised a biological tool that can not only detect faulty genetic circuits but also " debug " them - like running a patch cord around a computer hardware glitch. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

Bile duct cancer treatment potential boost from tailored medication -- study
(University of Birmingham) Treatment of patients suffering from bile duct cancer could be improved by tailoring medication to the levels of a key protein in people with the disease, according to new research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 14, 2020 Category: Cancer & Oncology Source Type: news

Researchers validate link between genetic variant and poor outcomes in advanced prostate cancer
(Cleveland Clinic) In a new Cleveland Clinic-led study published in JAMA Oncology, researchers show that a testosterone-related genetic variant -- HSD3B1(1245C) -- is associated with more aggressive disease and shorter survival in men with metastatic prostate cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Research pinpoints rogue cells at root of autoimmune disease
(Garvan Institute of Medical Research) Breakthrough cellular genomics technology has allowed Garvan and UNSW Sydney researchers to reveal genetic mutations causing rogue behaviour in the cells that cause autoimmune disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

New, detailed molecular roadmap boosts fight against endometrial cancer
(DOE/Pacific Northwest National Laboratory) Scientists have taken an unprecedented look at the proteins involved in endometrial cancer, commonly known as uterine cancer. The study offers insights about how physicians might be able to better identify which patients will need aggressive treatment and which won't, and offers clues about why a common cancer treatment is not effective with some patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

One's internal clock could be targeted to prevent or slow the progression of breast cancer
(City of Hope) City of Hope scientists have identified an unlikely way to potentially prevent or slow the progression of aggressive breast cancer: target one's internal clock. Studies have shown that women who take frequent night shifts have disrupted internal clocks and increased risk of developing breast cancer. Now, City of Hope's David K. Ann, Ph.D., has linked the 'clock gene' to triple-negative breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Better sleep may help pediatric cancer patients
(Rutgers University) Pediatric cancer patients may soon get a better night's sleep and experience improved comfort levels, thanks to a new grant-funded project led by a Rutgers University-Camden researcher. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Mathematical model reveals behavior of cellular enzymes
(Princeton University) Mathematical modeling helps researchers to understand how enzymes in the body work to ensure normal functioning. The models also can show how genetic mutations alter the enzymes' behavior in ways that cause disease, including cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Research calls for graphic warning labels to be added to cigarette packages
(MediaSource) Experts at the Center for Tobacco Research and The Ohio State University Comprehensive Cancer Center are making a case for why the U.S. Food and Drug Administration's (FDA) proposed rule to add 13 new graphic warnings for cigarette packages and advertisements should be allowed to go into effect. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Novel targeted drug shows promise in advanced kidney cancer
(Dana-Farber Cancer Institute) Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma (ccRCC) in patients with metastatic disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Rush earns National Center of Excellence for Pancreatic Cancer designation
(Rush University Medical Center) The National Pancreatic Foundation's National Center of Excellence for Pancreatic Cancer designation is earned by hospitals that demonstrate the multi-disciplinary approach, social support and advanced research resources needed to treat this devastating disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Autophagy genes act as tumor suppressors in ovarian cancer
(Medical University of South Carolina) Researchers at the Medical University of South Carolina and University of California at San Diego report in PLOS Genetics that the loss of BECN1 promoted early ovarian cancer formation and genomic instability. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Study surveys molecular landscape of endometrial cancer
(NYU Langone Health / NYU School of Medicine) The most comprehensive molecular study of endometrial cancer to date has further defined the contributions of key genes and proteins to the disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

New book on The PTEN Family from Cold Spring Harbor Laboratory Press
(Cold Spring Harbor Laboratory Press) 'The PTEN Family', from CSHLPress, covers all aspects of PTEN biology and its roles in human diseases. The contributors discuss the structural characteristics of PTEN; its functions at the plasma membrane as well as in the cytoplasm and nucleus; the mutations, interacting partners, and posttranslational modifications that affect its expression levels, subcellular localization, and enzymatic activity; and how this activity ultimately leads to changes in cell growth, migration, and morphology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Much shorter radiation treatment found to be safe, effective for people with soft tissue sarcoma
(University of California - Los Angeles Health Sciences) A new study led by researchers at UCLA found that treating soft tissue sarcoma with radiation over a significantly shorter period of time is safe, and likely just as effective, as a much longer conventional course of treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 13, 2020 Category: Cancer & Oncology Source Type: news

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks
(Impact Journals LLC) The cover for issue 6 of Oncotarget features Figure 3, 'The effect of NCs treatments on routine lab results during disease and recovery progress,' by Ben-Nun-Shaul, et al. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Evaluating skin cancer history by sexual orientation, gender identity
(JAMA Network) These two related studies and editorial examined the association of sexual orientation and gender identity with a history of self-reported skin cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Designer probiotic treatment for cancer immunotherapy
(Columbia University School of Engineering and Applied Science) Columbia Engineers have engineered probiotics to safely deliver immunotherapies within tumors, including nanobodies against two proven therapeutic targets -- PD-L1 and CTLA-4. Continuously released by bacteria, the drugs continue to attack the tumor after just one dose, facilitating an immune response resulting in tumor regression. The versatile probiotic platform can also be used to deliver multiple immunotherapies simultaneously, enabling the release of effective therapeutic combinations within the tumor for more difficult-to-treat cancers like colorectal ca...
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Gay and bisexual men have higher rate of skin cancer
(Brigham and Women's Hospital) In the largest study of skin cancer rates among gay, lesbian or bisexual individuals, investigators from Brigham and Women's Hospital report important differences in skin cancer prevalence among sexual minorities. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Absent p53, oral cancers recruit and reprogram nerves to fuel tumor growth
(University of Texas M. D. Anderson Cancer Center) Loss of an important tumor-suppressing gene allows head and neck cancer to spin off signals to nearby nerves, changing their function and recruiting them to the tumor, where they fuel growth and cancer progress. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Thyroid cancer, genetic variations, cell phones linked in YSPH study
(Yale School of Public Health) Radiation from cell phones is associated with higher rates of thyroid cancer among people with genetic variations in specific genes, a new study led by the Yale School of Public Health finds. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

NETRF funds $3.5 million in research to advance neuroendocrine tumor treatment
(Neuroendocrine Tumor Research Foundation) The Neuroendocrine Tumor Research Foundation (NETRF), Boston, MA, today announced $3.5 million in neuroendocrine tumor (NET) research grants to fund 12 projects around the world in pursuit of more precise treatments for this uncommon cancer affecting an estimated 171,000 Americans. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Cancer cells alter protein production machinery to hasten metastasis
(Massachusetts General Hospital) An increase in ribosomes, the protein-making machinery found in every living cell, increases their potential to form metastatic tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Researchers describe new condition involving numerous GI polyps in cancer survivors
(Dana-Farber Cancer Institute) Dana-Farber Cancer Institute researchers report newly discovered condition known as therapy-associated polyposis, or TAP in which childhood cancer survivors develop numerous colorectal growths called polyps. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 12, 2020 Category: Cancer & Oncology Source Type: news

Prebiotics help mice fight melanoma by activating anti-tumor immunity
(Sanford Burnham Prebys Medical Discovery Institute) Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that two prebiotics, mucin and inulin, slowed the growth of melanoma in mice by boosting the immune system's ability to fight cancer. The study, published today in Cell Reports, provides further evidence that gut microbes have a role in shaping the immune response to cancer, and supports efforts to target the gut microbiome to enhance the efficacy of cancer therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Foot-and-mouth-disease virus could help target the deadliest cancer
(Pancreatic Cancer Research Fund) The foot-and-mouth-disease virus is helping scientists to tackle a common cancer with the worst survival rate -- pancreatic cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Social control among immune cells improves defense against infections
(University of Freiburg) After infection, a simple mechanism ensures the balance between rapid expansion of immune cells and an excessive self-damaging reaction. This has now been deciphered by scientists at the University of Freiburg -- Medical Center (Germany) and international colleagues. The team has shown that activated T-cells are able to perceive each other and regulate their proliferation -- based on their density. The mechanism could help to improve cancer immunotherapies and was published in Immunity on Feb. 11. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

'Genetic rewiring' drives cancer's drug resistance
(Institute of Cancer Research) Tiny RNA molecule rewires signalling network in bile duct cancer. Drugs to block RNA could overcome cancer's drug resistance. Findings announced to coincide with Bile Duct Cancer Awareness Day. Results could be applicable in other cancer types and have wider benefit. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Utah researchers discover key protein in endometrial cancer growth
(Huntsman Cancer Institute) New research, published today in the journal Cancer Research, outlines findings scientists hope will advance our understanding of endometrial cancer and lead to more effective treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Replacing animal testing with synthetic cell scaffolds
(Michigan Technological University) Electrospun synthetic cell scaffolds are not only more consistent than animal cells for cancer research, they hold the potential to replace animal testing. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

PIONEER milestone - First two datasets uploaded into the PIONEER Big Data platform
(European Association of Urology) In an important step forward the first datasets have been transferred into the PIONEER Big Data platform by PIONEER partner Erasmus University Medical Centre (MC). Through the application of Big Data and the analyses of real-world evidence PIONEER aims to change the prostate cancer landscape to improve the health and social care received by all prostate cancer patients and their families. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2020 Category: Cancer & Oncology Source Type: news

Skin cancer diagnosis apps are unreliable and poorly regulated, study shows
(University of Birmingham) Smartphone apps used as 'early warning systems' for skin cancer are poorly regulated and frequently cannot be relied upon to produce accurate results, according to new analysis by experts at the University of Birmingham. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Cervical cancer elimination possible within two decades in the US
(Harvard T.H. Chan School of Public Health) At current levels of screening and HPV vaccination, cervical cancer incidence in the US is projected to fall below the threshold of elimination by 2038-2046. Scaling up screening coverage to 90% could expedite elimination timing by 10-13 years and avert an average of 1,400-2,088 additional cases per year. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Patient-partnered research finds clues about a rare cancer's genetic roots
(Broad Institute of MIT and Harvard) Working in close partnership with patients, scientists have identified new causes of a rare cancer of blood vessel walls called angiosarcoma. The research also points to possible therapeutic options for patients with this aggressive disease, who often have a poor prognosis. The study is a result of the Angiosarcoma Project, a unique partnership between patients and scientists that empowers patients to contribute their medical records, biological samples, and voices to accelerate research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Scientists closer to finding the cell of origin for ovarian cancer
(University of Oxford) Researchers have used a new technique to identify six previously unknown cell types in human Fallopian tubes, paving the way for faster identification and treatment of ovarian cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Human gut-in-a-dish model helps define 'leaky gut,' and outline a pathway to treatment
(University of California - San Diego) UC San Diego researchers use 3D human gut organoids to reveal the molecular system that keeps intestinal linings sealed, demonstrate how the system breaks down and how it can be strengthened with the diabetes drug metformin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Summary report on small cell lung cancer research points to progress and challenges
(International Association for the Study of Lung Cancer) In 2017, a group of lung cancer experts posed the question: 'Can recent advances in tumor biology that have led to progress treating non-small cell lung cancer translate into improved outcomes for small cell lung cancer?'According to an article " New Approaches to Small Cell Lung Cancer Therapy : From the Laboratory to the Clinic, " published in the February issue of the Journal of Thoracic Oncology, the answer is " yes. " (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Mass spectrometry for precision medicine -- Berlin's research leaders pool their expertise
(Charit é - Universit ä tsmedizin Berlin) Joint press release by Charit é and the MDCResearch groups from Charit é - Universit ä tsmedizin Berlin and the Max Delbr ü ck Center for Molecular Medicine (MDC) are pooling their expertise in the field of mass spectrometry, forming a new 'research core'. The aim of the MSTARS consortium is to further develop current technology for clinical application. The Federal Ministry of Education and Research (BMBF) will provide approximately € 5.7 million in funding for a minimum of three years. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Statins may lower mortality in high-risk prostate cancer patients
(Thomas Jefferson University) Statin use alone or with metformin is associated with lower prostate cancer mortality from all causes, among high-risk patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

Protocols used in Molecular Biology is now live
(Bentham Science Publishers) A compilation of various techniques in molecular biology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news

It's Iron, Man: ITMO scientists found a way to treat cancer with iron oxide nanoparticles
(ITMO University) Particles previously loaded with the antitumor drug are injected in vivo and further accumulate at the tumor areas. In order to release the drug non-invasively, the carrier particles have to be light-sensitive. For this purpose, the polymer containers (capsules) can be modified with iron oxide resonant semiconductor nanoparticles. When irradiated with light, they get heated and induce drug release. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2020 Category: Cancer & Oncology Source Type: news