New vulnerability found in lung squamous cancer may facilitate drug targeting
(UNC Lineberger Comprehensive Cancer Center) New cancer research by scientists at UNC Lineberger Comprehensive Cancer Center, and colleagues, shows the potential for targeting a specific circular RNA, known as CDR1as, to attack lung squamous cell cancer. Lung squamous cell cancers comprise up to 30% of all lung cancers and are responsible for about 70,000 new cases and approximately 40,000 deaths each year in the U.S. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 25, 2020 Category: Cancer & Oncology Source Type: news

Well-known molecule not found in cancer cells after all
(Aarhus University) A new research result from Aarhus University shows that a so-called circular RNA molecule, which has been designated as carcinogenic, is actually not found in the cancer cells. The results have just been published in Nature Communications. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

New analytical model detects mutations in breast cancer
(Lund University) Researchers at Lund University in Sweden have developed a computational model which is effective in detecting and identifying genetic mutations in breast tumours. The study, the largest of its kind in the world, includes results from over 3 200 patients with breast cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

St. Jude immunologist Thirumala-Devi Kanneganti, Ph.D., receives NCI award
(St. Jude Children's Research Hospital) The National Cancer Institute award provides extended support for researchers to pursue projects with groundbreaking cancer research potential. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

MD Anderson and Taiho Pharmaceutical announce collaboration to accelerate development of novel therapies for brain metastasis and other unmet medical needs
(University of Texas M. D. Anderson Cancer Center) The University of Texas MD Anderson Cancer Center and Taiho Pharmaceutical Co., Ltd., today announced a three-year strategic collaboration to accelerate the development of treatments for significant unmet medical needs in oncology, including patients with brain metastases and those with cancers refractory to available therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

Next-gen bioinformatics tool enables big data analysis without programming expertise
(University of Texas M. D. Anderson Cancer Center) A new data analysis tool developed by MD Anderson researchers incorporates a user-friendly, natural-language interface to aid biomedical researchers without bioinformatics or programming expertise to conduct intuitive data. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

UNH receives $1.8 million for biomolecular research in diabetes and cancer
(University of New Hampshire) The University of New Hampshire will receive $1.8 million from the National Institutes of Health (NIH) that will further molecular research to better understand drug interactions at the cellular level and help lead to the development of new targeted drugs to treat wide-spread metabolic, growth, neurological and visual disorders including diabetes and cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

UK cancer research could see £ 167 million drop in funding as a result of charity income loss
(National Cancer Research Institute) Due to the impact of the Covid-19 pandemic, cancer research charities are predicting their spending on research could drop by 46%, equating to £ 167m. Charities play a vital role in UK cancer research. Data collected by the National Cancer Research Institute (NCRI) shows that in the year 2018/19, charities accounted for over 50% of publicly funded cancer research, a total of £ 362m. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 24, 2020 Category: Cancer & Oncology Source Type: news

Scientists identify dozens of genes allowing cancer cells to evade the immune system
(University of Toronto) Cancer immunotherapy can be extremely successful but so far has only worked in a fraction of patients and tumour types. To make it more widely available, more knowledge is needed about the genes involved in the interaction between cancer and immune cells. In the most comprehensive study to date, Toronto scientists have mapped 182 genes that make cancer cells more susceptible or resistant to T cell killing that could be harnessed to boost immunotherapy success. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 23, 2020 Category: Cancer & Oncology Source Type: news

New NCCN resource for understanding childhood leukemia
(National Comprehensive Cancer Network) NCCN publishes a new patient and caregiver resource focused on a childhood cancer type. Free NCCN Guidelines for Patients: Pediatric Acute Lymphoblastic Leukemia (ALL) shares the latest expert advice for treating infants, children, and adolescents with the most common pediatric malignancy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 23, 2020 Category: Cancer & Oncology Source Type: news

NTU Singapore scientists devise 'Trojan horse' approach to kill cancer cells without using drugs
(Nanyang Technological University) Cancer cells are killed in lab experiments and tumour growth reduced in mice, using a new approach that turns a nanoparticle into a 'Trojan horse' that causes cancer cells to self-destruct, a research team at the Nanyang Technological University, Singapore (NTU Singapore) has found. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 23, 2020 Category: Cancer & Oncology Source Type: news

New insights into colorectal cancer: Growth factor R-spondin suppresses tumor growth
(University of Helsinki) R-spondin, which enhances the growth of healthy cells in the gut, suppresses the growth of intestinal adenoma cells, thus reducing the formation of intestinal tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 23, 2020 Category: Cancer & Oncology Source Type: news

Why some cancers may respond poorly to key drugs discovered
(University of Texas at Austin) Scientists have identified a driver of drug resistance in breast, ovarian and prostate cancers that may help doctors predict which patients will become resistant to a class of drugs frequently used to treat BRCA 1/2-deficient tumors. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 22, 2020 Category: Cancer & Oncology Source Type: news

The co-occurrence of cancer driver genes, key to precision medicine
(Institute for Research in Biomedicine (IRB Barcelona)) Researchers from the Structural Bioinformatics and Network Biology Laboratory at IRB Barcelona develop a system to predict tumour response to different treatments.Called Targeted Cancer Therapy for You (TCT4U), this system has allowed them to identify a set of complex biomarkers that are available to the medical-scientific community.The work has been published in the journal Genome Medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 22, 2020 Category: Cancer & Oncology Source Type: news

Cancer survivors urgently need better nutritional support
(University of Sheffield) New research from the University of Sheffield reveals an urgent need to improve clinical practice to help colorectal cancer patients overcome nutritional difficulties throughout diagnosis, treatment and post-treatment (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Fred Hutch-led clinical trial shows new smartphone app helps smokers quit
(Fred Hutchinson Cancer Research Center) Scientists at Fred Hutchinson Cancer Research Center believe they've found a better of use of mobile technology to help adult cigarette smokers quit. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Study: Black women with breast cancer experience delayed, longer treatment than whites
(UNC Lineberger Comprehensive Cancer Center) One in seven black women with breast cancer had delays in starting treatment, and black women also had extended duration of treatment, according to a study led by UNC Lineberger Comprehensive Cancer Center researchers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Immunotherapy is beneficial in gastric and oesophageal cancers, studies show
(European Society for Medical Oncology) New data presented at ESMO 2020 have shown that immunotherapy is beneficial for patients with gastric and oesophageal cancers who currently have poor survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Penn researchers discover potential cause of immunotherapy-related neurotoxicity
(University of Pennsylvania School of Medicine) New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB). This discovery may potentially be the cause for neurotoxicity in patients undergoing CD19 directed CAR T cell immunotherapy, according to the research team led by Avery Posey, PhD, an assistant professor of Systems Pharmacology and Translational Therapeutics at the University of Pennsylvania. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Making sense of diabetes
(University of Missouri-Columbia) Throughout her 38-year nursing career, Laurel Despins has progressed from a bedside nurse to a clinical nurse specialist and has worked in medical, surgical and cardiac intensive care units. She noticed diabetes is rarely referred to as a primary cause of death in itself, yet the disease is a leading contributor to deaths involving heart disease, stroke and cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Cellular processes and social behaviors and... zombies?
(Arizona State University) The Zombie Apocalypse Medicine Meeting will happen online October 15-18, 2020. The meeting spans the sciences, the arts and the scary while bringing scientists, artists and journalists together with the general public. This year's meeting has been reanimated into a livestream broadcast on Channel Zed. Registrants will have access to programming on topics like how birth control, race relations, the pandemic, sex, literature and social media can all be thought of as zombification processes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

Black women may be less likely to receive timely treatment for breast cancer
(Wiley) New research suggests that Black women experience longer waits for treatment initiation than white women after a breast cancer diagnosis, and their duration of treatment is prolonged. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS). (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 21, 2020 Category: Cancer & Oncology Source Type: news

KRAS inhibitor sotorasib appears safe, achieves durable clinical benefit in early trial
(University of Texas M. D. Anderson Cancer Center) For patients with advanced solid cancers and KRAS G12C mutations, the targeted therapy sotorasib, a KRAS G12C inhibitor, resulted in manageable toxicities and durable clinical benefits, particularly in lung and colorectal cancer, in Phase I study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 20, 2020 Category: Cancer & Oncology Source Type: news

Immunotherapy combination improves outcomes in advanced kidney cancer
(Dana-Farber Cancer Institute) An immunotherapy agent combined with a tyrosine kinase inhibitor drug significantly improved progression-free survival and reduced the risk of death compared to a single agent treatment in advanced kidney cancer patients, according to first results of a phase 3 clinical trial. The pivotal study could lead to a new treatment option for patients with metastatic kidney cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 19, 2020 Category: Cancer & Oncology Source Type: news

Unleashing Canada's radiopharmaceutical excellence
(PR Associates) The Centre for Probe Development and Commercialization (CPDC) and adMare BioInnovations (adMare) are pleased to announce they have formed a new collaboration, " The CPDC-adMare Radiopharmaceutical Initiative (CARI) " to bring their respective resources together to advance an area of tremendous therapeutic and commercial potential in which Canada can gain a considerable global competitive advantage: radiopharmaceuticals. This field revolutionized precision medicine by the use of theranostics where targeted therapies are combined with diagnosis, treatment planning, drug delivery, and response assess...
Source: EurekAlert! - Cancer - September 18, 2020 Category: Cancer & Oncology Source Type: news

Increasing the effectiveness of immunotherapy against skin cancer
(University of Bern) Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturation and activation of immune cells. In the fight against skin cancer, the results have the potential to help immunotherapies succeed, even in patients for whom they have so far been ineffective. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 18, 2020 Category: Cancer & Oncology Source Type: news

American Roentgen Ray Society planning all-virtual 2021 Annual Meeting: April 18-22
(American Roentgen Ray Society) The American Roentgen Ray Society (ARRS) will convene its 2021 Annual Meeting as an all-virtual event from April 18-22, 2021. The first imaging society to announce an all-virtual assembly for 2021, ARRS promises to deliver the same clinically relevant experience for which its Annual Meeting has long been heralded: world-class educational activities led by the field's foremost experts that span every subspecialty of radiology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 18, 2020 Category: Cancer & Oncology Source Type: news

Spotting breast cancer's spread to the brain before symptoms start could improve survival
(European Organisation for Research and Treatment of Cancer) Breast cancer patients whose disease has spread to their brains fare better if their metastases are picked up before they begin to cause symptoms, according to a study presented at the 12th European Breast Cancer Conference. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Pattern of gut bacteria linked to effectiveness of chemotherapy in breast cancer patients
(European Organisation for Research and Treatment of Cancer) Researchers studying the activity of gut bacteria in breast cancer patients have found a possible link with how well their chemotherapy works. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Access to cancer medicines and clinical trials show stark variations across Europe
(European Society for Medical Oncology) Access to cancer medicines is highly unequal across Europe both for new drugs in development because of uneven access to clinical trials and for currently approved drugs due to huge disparities in healthcare spending by different countries, according to results from studies presented at ESMO 2020. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

New study estimates nearly 90,000 cancer cases diagnosed in adolescents and young adults
(American Cancer Society) A new report examining cancer in adolescents and young adults (AYAs), defined as diagnoses occurring during ages 15 to 39, provides updated estimates of the contemporary cancer burden in this age group, predicting that 89,500 cases and 9,270 deaths will occur in 2020 in the United States. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Three common medications lower risk and mortality for lung cancer
(International Association for the Study of Lung Cancer) Combined use of aspirin, statins, and metformin is associated with decreased lung cancerincidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Examining association of coffee consumption, survival in patients with colorectal cancer
(JAMA Network) Researchers in this observational study investigated the association between the number of cups of coffee consumed per day and survival in patients with advanced or metastatic colorectal cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Changes in lung cancer treatment during COVID-19 pandemic
(JAMA Network) Changes in   lung cancer treatment during the COVID-19 pandemic were evaluated in this study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Coffee associated with improved survival in metastatic colorectal cancer patients
(Dana-Farber Cancer Institute) In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and a lower risk of the cancer worsening, researchers at Dana-Farber Cancer Institute and other organizations report in a new study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

The Mark Foundation launches Inaugural Industry Advisory Committee
(The Mark Foundation for Cancer Research) What's especially interesting here is that we developed a new playbook for the how foundations can play a transformational role in bridging the gap between great academic ideas and marketed products - getting past the " valley of death. " (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

New partnership to build advanced predictive testing for blood cancer multiple myeloma
(RCSI) By combining genomic testing and next generation sequencing technology, a new partnership led by RCSI researchers aims to advance predictive tests for multiple myeloma (MM), the second most common blood cancer in Ireland. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Kang finds keys to control the 'driver of cancer's aggressiveness'
(Princeton University) A dangerous protein named SNAI2 helps cancers metastasize and shields cancer from both the immune system and chemotherapy. Worse, SNAI2 is in a family of proteins that are notoriously hard to fight with drugs. But now Princeton University's Yibin Kang and his colleagues have found a way to use the cell's recycling system to control SNAI2, providing a new possibility for treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

NIH funds research into differences in glioblastoma between males and females
(Cleveland Clinic) A team led by researchers from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute has secured $10.4 million over five years from the National Institutes of Health/National Cancer Institute to explore at the molecular level the differences in glioblastoma between males and females. The researchers will delve into the genetics, epigenetics and cell biology of glioblastoma - the most common and deadliest brain tumor in adults - to better understand the physiologic processes which may lead to more personalized therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

PPIs may affect responses to atezolizumab in patients with urothelial cancer
(American Association for Cancer Research) Proton pump inhibitor (PPI) use was associated with worse outcomes in patients with urothelial cancer treated with the immunotherapeutic atezolizumab (Tecentriq), compared with patients who did not use PPIs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 17, 2020 Category: Cancer & Oncology Source Type: news

Building bridges: PARP enzymes bring broken DNA together
(St. Jude Children's Research Hospital) St. Jude researchers capture the structure of PARP enzymes at work, leading to a new understanding of DNA repair that may aid cancer treatments targeting the process. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Breast cancer surgery type, quality of life among younger women
(JAMA Network) Researchers investigated differences in quality of life and other outcomes (including physical functioning, body image, sexual health, anxiety and depressive symptoms) by type of breast cancer surgery (such as mastectomy or breast conserving surgery) in women 40 and younger. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Scientists updated genome editing technology
(Peter the Great Saint-Petersburg Polytechnic University) International scientific group compared their developed carriers for delivery of genome editing (GE) tools with other available analogues. The research of current studies were published in the in the journal Biomaterials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Stop Livin to make lymphoma cells stop living
(University of Tsukuba) Researchers at the University of Tsukuba have shown that the protein Livin, an inhibitor of apoptosis or programmed cell death, mediates resistance to immunotherapy in some lymphoma variants. Therapeutically targeting Livin with IAP inhibitors or BET inhibitors may provide a practical strategy for patients with Livin-positive and other refractory B-cell lymphomas. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Immune 'cloaking' in cancer cells and implications for immunotherapy
(Queen Mary University of London) Researchers at Queen Mary University of London, The Institute of Cancer Research, London, and the Moffitt Cancer Centre have created a mathematical model that can determine the impact of the immune system on tumour evolution. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Entrepreneurs to pitch new health-care innovations in virtual event
(University of Massachusetts Lowell) Entrepreneurs developing medical devices and technologies to improve health outcomes will pitch their innovations to a panel of expert judges for the chance to share in $200,000 in in-kind resources to advance their work during a virtual event to be held on Thursday, Sept. 17 at 5 p.m. ET (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Discoveries made in how immune system detects hidden intruders
(Texas A&M University) Research led by Dr. Wonmuk Hwang has led to better understanding on how components of the body's immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Reducing colorectal cancer disparities among African american men
(Huntsman Cancer Institute) Out of any other racial group, African American men have the lowest five-year survival rate for colorectal cancer (CRC). Yet, published research on effective strategies to increase screening for this group specifically are minimal. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Oncotarget: ATM inhibition overcomes resistance to histone deacetylase inhibitor
(Impact Journals LLC) The cover for issue 37 of Oncotarget features Figure 7, " The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL, " by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 16, 2020 Category: Cancer & Oncology Source Type: news

Researchers use soy to improve bone cancer treatment
(Washington State University) Researchers showed that the slow release of soy-based chemical compounds from a 3D-printed bone-like scaffold resulted in a reduction in bone cancer cells while building up healthy cells and reducing harmful inflammation. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 15, 2020 Category: Cancer & Oncology Source Type: news