Predicts the onset of Alzheimer's Disease (AD) using deep learning-based Splice-AI
This study reported for the first time, which identified the gene mutations and abnormal splicing of PLCg1 gene in AD using both high-throughput screening data and a deep learning-based prediction (Splice-AI) (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 27, 2021 Category: International Medicine & Public Health Source Type: news

Advanced practice nurses reduce hospitalizations from nursing home residents
(University of Missouri-Columbia) Marilyn Rantz still remembers the day she got the call that her mother, whose health had been declining, had fallen and fractured her shoulder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Early PDA closure may improve outcomes in preterm infants
(Le Bonheur Children's Hospital) Extremely low birth weight (ELBW) infants with moderate to large patent ductus arteriosus (PDA) may benefit from transcatheter PDA closure (TCPC) in the first four weeks of life, according to research published by Le Bonheur Cardiologist Ranjit Philip, MD, and Medical Director of Interventional Cardiac Imaging and Interventional Catheterization Laboratory Shyam Sathanandam, MD. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

How housing discrimination affects environmental inequality
(University of Illinois College of Agricultural, Consumer and Environmental Sciences) Economists and urban planners generally agree that local pollution sources disproportionally impact racial minorities in the U.S. The reasons for this are largely unclear, but a University of Illinois study provides new insights into the issue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Blood tests offer early indicator of severe COVID-19, study says
(Yale University) When patients with COVID-19 arrive in emergency rooms, there are relatively few ways for doctors to predict which ones are more likely to become critically ill and require intensive care and which ones are more likely to enjoy a quick recovery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

New research finds exercise may help slow memory loss for people living with Alzheimer's dementia
(IOS Press) Promising new research shows aerobic exercise may help slow memory loss for older adults living with Alzheimer's dementia. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Exposure to diverse career paths can help fill labor market 'skills gap'
(University of Missouri-Columbia) When Patrick Rottinghaus began college, he had no idea what he wanted to do with his career. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

New journal launched, The International Journal of Gastroenterology & Hepatology Diseases
(Bentham Science Publishers) Bentham Science is pleased to announce the launch of new subscription-based journal, The International Journal of Gastroenterology and Hepatology Diseases. The first issue of the journal will be available online by the start of the year, 2021. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Bentham Science launches new journal, < i > Current Cosmetic Science < /i >
(Bentham Science Publishers) Bentham Science is pleased to announce the launch of a new subscription-based journal,Current Cosmetic Science. The first issue of the journal will be available online by the start of the year, 2021. The journal is edited by Dr. Syed A.A. Rizvi. Dr. Syed Rizvi is currently associated with Hampton University, Hampton, VA, USA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

C-Path and Global Partners launch Ataxia Consortium
(Critical Path Institute (C-Path)) Critical Path Institute today announced the launch of the Critical Path to Therapeutics for the Ataxias Consortium, a public-private partnership focused on optimizing clinical trials for inherited ataxias. CPTA is a collaborative effort between C-Path, Ataxia Global Initiative, the National Ataxia Foundation, Ataxia UK and key partners in the industry and academic research communities, including Biohaven Pharmaceuticals, Ionis Pharmaceuticals, Roche Pharmaceuticals, Servier Group, Triplet Therapeutics, uniQure, and Vico Therapeutics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Cerium sidelines silver to make drug precursor
(Rice University) Rice University scientists have developed a greatly simplified method to make fluoroketones, a precursor for drug design and manufacture that typically requires an expensive silver catalyst. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Researchers identify characteristics of highest utilizers for mental health hospital services
(University of Texas Health Science Center at Houston) Dropping out of high school, having schizophrenia, or being diagnosed with a co-occurring personality disorder increases the likelihood of someone becoming a 'high utilizer' of inpatient psychiatric hospital services, according to a new study by researchers at UTHealth. A high utilizer is someone who has been admitted three or more times within one year. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Sensing robot healthcare helpers being developed at SFU
(Simon Fraser University) Robots that could take on basic healthcare tasks to support the work of doctors and nurses may be the way of the future. Who knows, maybe a medical robot can prescribe your medicine someday? That's the idea behind 3D structural-sensing robots being developed and tested at Simon Fraser University by Woo Soo Kim, associate professor in the School of Mechatronic Systems Engineering. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Deep brain stimulation and exercise restore movement in ataxia
(Baylor College of Medicine) New research from Baylor College of Medicine scientists shows that a combination of deep brain stimulation (DBS) and exercise has potential benefits for treating ataxia, a rare genetic neurodegenerative disease characterized by progressive irreversible problems with movement. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Atherosclerosis can accelerate the development of clonal hematopoiesis, study finds
(Massachusetts General Hospital) Studies have shown that clonal hematopoiesis often goes hand in hand with atherosclerosis and cardiovascular disease. Since its discovery, this surprising association has been the subject of intense interest from clinicians and researchers alike. Patients with atherosclerosis suffer from hyperlipidemia and inflammation, two conditions that are known to chronically boost hematopoietic stem cell division rates. In the new study, the researchers now demonstrate that this increased division accelerates the development of clonal hematopoiesis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

University of Minnesota to host webinar - Is COVID-19 changing research ethics?
(University of Minnesota) On Wednesday, March 3, the University of Minnesota will host top national experts to debate how COVID-19 is changing the rules and conduct for research. This webinar on 'Conducting Research in the COVID-19 Pandemic: Ethics in an Emergency' will tackle huge issues. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Picture books can boost physical activity for youth with autism
(University of Missouri-Columbia) While physical activity is important for everyone, research has shown people with developmental disabilities do not exercise as often as their typically developed peers. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Oahu marine protected areas offer limited protection of coral reef herbivorous fishes
(University of Hawaii at Manoa) Marine protected areas around O?ahu do not adequately protect populations of herbivorous reef fishes that eat algae on coral reefs. That is the primary conclusion of a study published in Coral Reefs by researchers from the University of Hawai?i at Mānoa. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

UTA researcher explores effects of trauma at the cellular, tissue levels of the brain
(University of Texas at Arlington) Ashfaq Adnan, professor of mechanical and aerospace engineering, has received a three-year, $944,845 grant to study the potential link between blast-like trauma and cellular and tissue damage in the brain. By using ultra-high-speed cameras to capture dynamic events within a simulated brain, he will be able to look at rapid acceleration and deceleration to investigate what happens during such events. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Retroviruses are re-writing the koala genome and causing cancer
(Leibniz Institute for Zoo and Wildlife Research (IZW)) Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss - accelerated by last year's devastating bush fires - domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. An international team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) now demonstrate that a retrovirus invading the koala germline explains the high frequency of koala cancer. The results are reported in the journalNature Communications. (...
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

The key to proper muscle growth
(Max Delbr ü ck Center for Molecular Medicine in the Helmholtz Association) Three oscillating proteins cause new muscle cells to emerge from muscle stem cells in a balanced manner. In a paper being published in the journalNature Communications, a team led by MDC researcher Carmen Birchmeier explains in detail how this process works. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

MicroRNA testing of healthy kids could provide a window on future heart and kidney health
(The Mount Sinai Hospital / Mount Sinai School of Medicine) Molecules called microRNAs (miRNAs) that are measurable in urine have been identified by researchers at Mount Sinai as predictors of both heart and kidney health in children without disease. The epidemiological study of Mexican children was published in February in the journal Epigenomics. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Not all " good " cholesterol is healthy
(IMIM (Hospital del Mar Medical Research Institute)) A study led by IMIM examines whether all so-called good cholesterol (HDL) particles have a cardiovascular protective effect. Traditionally, HDL cholesterol has been associated with a reduced risk of heart disease, but there are doubts as to whether all the particles have a protective effect. The work shows that people with large HDL particles have an increased risk of myocardial infarction, while only small HDL particles are actually associated with decreased risk. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Curcumin for amyloidosis and lipid metabolism -- a novel insight
This study demonstrates that curcumin is a PPARα/γ dual activator and may affect expression levels of proteins involved in amyloid deposition and other metabolism functions in a complex manner. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

New open-source platform accelerates research into the treatment of heart arrhythmia's
(King's College London) An open-source platform, OpenEP co-developed by researchers from the School of Biomedical Engineering& Imaging Sciences at King's College London has been made available to advance research on atrial fibrillation, a condition characterised by an irregular (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Using artificial intelligence to hunt for breast cancer
(BfR Federal Institute for Risk Assessment) Endocrine disruptors (EDs) are hormone-like substances that can have undesirable effects on health. For example, chemicals can increase the risk of breast cancer if they act in a manner similar to the female sex hormone oestrogen. Animal experiments are still required to detect the hormonal effects of chemical substances. A test has now been developed at the German Centre for the Protection of Laboratory Animals (Bf3R) that tests the effects of hormones on cultured human cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Advantageous preparation of movement via independent control of muscle sensors
(Umea University) A number of brain areas change their activity before we execute a planned voluntary movement. A new study by Ume å University identifies a novel function of this preparatory neural activity, highlighting another mechanism the nervous system can use to achieve its goals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Multiple aspects of Coronavirus disease
(Bentham Science Publishers) This book presents the basic and advanced knowledge about the COVID-19 pandemic, organized into simple and easy-to-read chapters. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Improving durability of dental structures
(Charit é - Universit ä tsmedizin Berlin) How can dental restorations - such as fillings and crowns - be made to last longer? A new research group centered at Charit é - Universit ä tsmedizin Berlin and Technische Universit ä t (TU) Berlin plans to address this topic by utilizing approaches from both materials science and dentistry. The aim is to gain a better understanding of the composition and structure of the material-tissue interfaces and the stresses exerted on them. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice
(University of the Witwatersrand) Furthermore, the targeted Indoor Residual Spraying (IRS) intervention was safe, less costly, and more cost-effective compared with standard 'blanket' IRS, meaning savings could potentially be reallocated to other malaria control and elimination activities. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

SARS-CoV-2 mutations in competition
(University of Bern) How dangerous are new mutations of the SARS-CoV-2 virus? An international team involving researchers from the Institute of Virology and Immunology (IVI) of the Federal Food Safety and Veterinary Office BLV and the University of Bern (Switzerland), the Centers for Disease Control and Prevention (USA), and the Friedrich-Loeffler Institute (Germany), has developed an approach that can accurately assess the transmissibility of new virus mutants. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

A missing protein promotes genetic instability in patients with Mulibrey syndrome
(University of Seville) The absence of the TRIM37 protein induces the formation of centrosomes in cells in turn favouring the development of tumours. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2021 Category: International Medicine & Public Health Source Type: news

Researcher identifies potential new measure for Alzheimer's risk
(University of Tennessee Health Science Center) Early diagnosis of Alzheimer's disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. A recent study, published in theJournal of Alzheimer's Disease, has found a novel way to identify a high potential for developing Alzheimer's disease before symptoms occur. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Diversity among study participants credited with identifying gene linked to asthma
(Henry Ford Health System) Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.The study is published in the print version of the American Journal of Respiratory and Critical Care Medicine. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Nanomedicine activation profile determines efficacy depending on tumor c-Myc expression
(Innovation Center of NanoMedicine) The half-life of a potent c-Myc inhibitor JQ1H was improved by encapsulating inside nanomicelles. Two types of nanomicelles were designed depending on the tumor acidity-driven activation; one is fast drug-releasing (FR-JQ1H/m), and another is slow releasing (SR-JQ1H/m). Anticancer activity study in mice revealed that FR-JQ1H/m was more effective in c-Myc high tumor, whereas SR-JQ1H/m was superior in c-Myc low tumor. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Development of an electroceutical to drastically reduce high-risk, preterm labor
(National Research Council of Science& Technology) The Korea Institute of Science and Technology (KIST) announced that in collaboration with the research team led by Ki Hoon Ahn, Professor at the Department of OB/GYN, Korea University Anam Hospital and Dr. Soo Hyun Lee, the team at KIST Brain Science Institute (BSI) developed a non-invasive electroceutical for the early detection and simultaneous treatment of preterm labor. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

OHSU study advances field of precision medicine
(Oregon Health& Science University) Researchers at Oregon Health& Science University have demonstrated a new method of quickly mapping the genome of single cells, while also clarifying the spatial position of the cells within the body. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Early-warning for seizures could be a game-changer for epilepsy patients
(University of Southern California) A research team at USC Viterbi School of Engineering and Keck Medicine of USC has developed mathematical model to predict seizures that will give epilepsy patients an accurate warning five minutes to one hour before they are likely to experience a seizure. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Chip simplifies COVID-19 testing, delivers results on a phone
(Rice University) Programmed magnetic nanobeads paired with an off-the-shelf cellphone and plug-in diagnostic tool can diagnose COVID-19 in 55 minutes or less. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

New treatment location challenges thoughts on addiction
(Medical University of South Carolina) In a recent paper inDrug and Alcohol Dependence, researchers at MUSC evaluated two different strategies for relieving pain with TMS: applying TMS to the motor cortex and the DLPFC. As a pilot study, the paper kicks off a new area of research. It represents the first attempt at a randomized comparison of these two potential treatment targets, and it suggests that the motor cortex is an important and influential part of the addiction process. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Artificial 'brain' reveals why we can't always believe our eyes
(University of Cambridge) A computer network closely modelled on part of the human brain is enabling new insights into the way our brains process moving images - and explains some perplexing optical illusions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Salk Professors Satchin Panda and Tatyana Sharpee honored with endowed chairs
(Salk Institute) Professors Satchin Panda and Tatyana Sharpee have both been recognized for their contributions and dedication to advancing science through research by being named to endowed chairs at the Salk Institute. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Male lyrebirds create an " acoustic illusion " to snare potential mates
(Cornell University) Famous for their uncanny ability to imitate other birds and even mechanical devices, researchers find that Australia's Superb Lyrebird also uses that skill in a totally unexpected way. Lyrebirds imitate the panicked alarm calls of a mixed-species flock of birds while males are courting and even while mating with a female. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

New radiology research shows promising results for focused ultrasound treatment of Alzheimer's
(West Virginia University) West Virginia University scientists used MRI scans to show what happens when ultrasound waves target a specific area of Alzheimer's patient's brains. They concluded that this treatment may induce an immunological healing response, a potential breakthrough for a disease that accounts for up to 80% of all dementia cases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Study finds changes in gut microbiome connected to Alzheimer's-like behavior
(Oregon Health& Science University) New research in mice published today in the journal Scientific Reports strengthens the growing scientific consensus regarding the role of the gut microbiome in neurodegenerative disorders including Alzheimer's disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Market design to accelerate COVID-19 vaccine supply
(American Association for the Advancement of Science) Although the value of vaccines for COVID-19 may seem obvious, government action and investment in vaccines have not been commensurate with the enormous scale of benefits they offer, argue Juan Camilo Castillo and colleagues in this Policy Forum. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

UIC researchers find new biomarker for active sarcoidosis
(University of Illinois at Chicago) Low blood levels of immune cells called lymphocytes, in combination with higher levels of inflammation on PET/CT scans, are indicators of active sarcoidosis -- an inflammatory disease that attacks multiple organs, particularly the lungs and lymph nodes -- which disproportionately affects African Americans. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

A cat of all trades
(University of Copenhagen - Faculty of Science) The leopard stands out as an elusive, versatile, and adaptable animal. Researchers from the University of Copenhagen have just published the first genomic data for the African subspecies of the leopard in the acclaimed Cell Press journal Current Biology. The results showed an exceptionally high genetic diversity compared to other top predators, transforming our understanding of population dynamics in species at the top of the food chain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Just published: Compilation of research on PFAS in the environment
(Society of Environmental Toxicology and Chemistry) Recently, Environmental Toxicology and Chemistry (ET&C) published a special issue dedicated to PFAS with 32 articles, providing a valuable summarization of risk assessment approaches for PFAS, which are needed for environmental managers and regulatory bodies to set appropriate drinking water standards and health advisory guidelines. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news

Removing one barrier to opioid use disorder treatment
(Yale University) The Department of Health and Human Services (HHS) submitted notice to the Federal Register that it would issue practice guidelines that exempt physicians from the requirement to apply for a waiver to prescribe buprenorphine to treat opioid use disorder (OUD) in up to 30 patients at one time. This exemption has been placed on hold by the Biden administration and may require legislative change to implement. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 25, 2021 Category: International Medicine & Public Health Source Type: news