Glia-derived exosomes: Promising therapeutic targets
Publication date: Available online 15 October 2019Source: Life SciencesAuthor(s): He Li, Yin Luo, Luojiang Zhu, Weilong Hua, Yongxin Zhang, Hongjian Zhang, Lei Zhang, Zifu Li, Pengfei Xing, Yongwei Zhang, Bo Hong, Pengfei Yang, Jianmin LiuAbstractGlia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste,...
Source: Life Sciences - October 16, 2019 Category: Biology Source Type: research

Observation after surgery for low grade glioma: long-term outcome in the light of the 2016 WHO classification
ConclusionThe strongest determinant of the patients ’ course after initial watchful waiting was the molecular tumor status. Extensive resection may increase time to progression and malignant transformation. Observation may be justified in selected patients. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 16, 2019 Category: Cancer & Oncology Source Type: research

Association between extent of resection on survival in adult brainstem high-grade glioma patients
This study aimed to clarify the survival in adult patients.MethodsWe utilized the SEER database (1973 –2015) to analyze the association between survival and demographic data, tumor characteristics, and treatment factors in adult patients with brainstem HGGs. Patients without surgical intervention were excluded. Overall survival (OS) was analyzed using univariable and multivariable Cox regression.ResultsOur dataset included a total of 502 brainstem HGG patients of which only those who had undergone surgical intervention were included in the analysis, totaling 103. Mean age was 42.4  ± 14.1 years w...
Source: Journal of Neuro-Oncology - October 16, 2019 Category: Cancer & Oncology Source Type: research

Intraoperative radiotherapy for glioblastoma: an international pooled analysis
Glioblastoma (GB) represents the most frequent primary malignancy of the brain in adults, accounting for more than half of all gliomas [1]. Survival times are still narrow and range between 1 and 3  years [2–6]. Even patients with favorable risk factors, such as young age, high Karnofsky performance status (KPS) and hypermethylation of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter suffer from tumor recurrence, usually occurring 14–17 months after therapy [2,6]. (Source: Radiotherapy and Oncology)
Source: Radiotherapy and Oncology - October 16, 2019 Category: Radiology Authors: Gustavo R. Sarria, Elena Sperk, Xiaodi Han, Gustavo J. Sarria, Frederik Wenz, Stefanie Brehmer, Bing Fu, Siming Min, Hongjun Zhang, Shusen Qin, Xiaoguang Qiu, Daniel H änggi, Yasser Abo-Madyan, David Martinez, Carla Cabrera, Frank A. Giordano Tags: Original Article Source Type: research

Repurposing Antipsychotics of the Diphenylbutylpiperidine Class for Cancer Therapy
Publication date: Available online 13 October 2019Source: Seminars in Cancer BiologyAuthor(s): Vikram Shaw, Suyash Srivastava, Sanjay K. SrivastavaAbstractThe recent development of high throughput compound screening has allowed drug repurposing to emerge as an effective avenue for discovering novel treatments for cancer. FDA-approved antipsychotic drugs fluspirilene, penfluridol, and pimozide are clinically used for the treatment of psychotic disorders, primarily schizophrenia. These compounds, belong to diphenylbutylpiperidine class of antipsychotic drugs, are the potent inhibitors of dopamine D2 receptor and calcium chan...
Source: Seminars in Cancer Biology - October 15, 2019 Category: Cancer & Oncology Source Type: research

Identification of a Five-Pseudogene Signature for Predicting Survival and Its ceRNA Network in Glioma
Conclusions: In this study, a risk signature with five pseudogenes was constructed and shown to accurately predict 1-, 3-, and 5-year survival for glioma patient. The risk signature may serve as a potential target against glioma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - October 15, 2019 Category: Cancer & Oncology Source Type: research

MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings
Glioma is the most malignant brain tumors in the world, the function and molecular mechanism of microRNA-199a (miR-199a) in glioma is not fully understood. Our research aims to investigate miR-199a/K-RAS axis in regulation of glioma tumor growth and chemoresistance. The function of miR-199a in glioma was investigated through in vitro and in vivo assays. We found that miR-199a in tumor tissues of glioma patients was significantly downregulated in this study. Kinase suppressor of ras 1 (K-RAS), was indicated as a direct target of miR-199a, as well as expression levels of K-RAS were inversely correlated with expression levels...
Source: Frontiers in Oncology - October 15, 2019 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 11, Pages 1564: Genetic and Lineage Classification of Glioma-Initiating Cells Identifies a Clinically Relevant Glioblastoma Model
ai Satoshi Iwabuchi The Cancer Genome Atlas (TCGA) project described a robust gene expression-based molecular classification of glioblastoma (GBM), but the functional and biological significance of the subclasses has not been determined. The present comprehensive analysis of 25 glioma-initiating cell (GIC) lines classifies GIC lines into four subtypes (classical, mesenchymal, proneural, and neural) that are closely related to the TCGA GBM subclasses and display distinct lineage characteristics and differentiation behavior that recapitulate neural development. More importantly, the GIC subtypes exhibit distinct biolog...
Source: Cancers - October 15, 2019 Category: Cancer & Oncology Authors: Norihiko Saito Nozomi Hirai Kazuya Aoki Sho Sato Ryo Suzuki Yu Hiramoto Satoshi Fujita Haruo Nakayama Morito Hayashi Takatoshi Sakurai Satoshi Iwabuchi Tags: Article Source Type: research

Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells
ConclusionThis is the first study reporting the regulation ofEGFR transcription by EVI1 in GBM cells. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 15, 2019 Category: Cancer & Oncology Source Type: research

Pediatric High Grade Glioma Resources from the Children's Brain Tumor Tissue Consortium (Cbttc).
, Cole KA, Children’s Brain Tumor Tissue Consortium PMID: 31613963 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - October 15, 2019 Category: Cancer & Oncology Authors: Ijaz H, Koptyra M, Gaonkar KS, Rokita JL, Baubet VP, Tauhid L, Zhu Y, Brown M, Lopez G, Zhang B, Diskin SJ, Vaksman Z, Mason JL, Appert E, Lilly J, Lulla R, De Raedt T, Heath AP, Felmeister A, Raman P, Nazarian J, Santi MR, Storm PB, Resnick A, Waanders A Tags: Neuro Oncol Source Type: research

Prediction of Hypoxia in Brain Tumors Using a Multivariate Model Built from MR Imaging and 18F-Fluorodeoxyglucose Accumulation Data.
CONCLUSION: A multivariate prediction model created using blood flow, vascular permeability, and glycometabolism parameters can predict the extent of hypoxia in FMISO-positive areas in patients with brain tumors. PMID: 31611541 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medical Sciences : MRMS)
Source: Magnetic Resonance in Medical Sciences : MRMS - October 15, 2019 Category: Radiology Authors: Shimizu Y, Kudo K, Kameda H, Harada T, Fujima N, Toyonaga T, Tha KK, Shirato H Tags: Magn Reson Med Sci Source Type: research

Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor- β/SMAD signaling pathway.
This study aimed to disclose the effect of retinol dehydrogenase 10 (RDH10) on the migration and invasion of glioma cells, and to explore the potential mechanism. METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used to determine the expression levels of RDH10 in healthy glial cells and glioma cells. Human glioma cell strains, U87 and U251, were infected with negative control or RDH10-interfering lentiviruses. RT-PCR and Western blotting were performed to determine the knockdown efficiency. Scratch and transwell assays were used to assess cell migration and invasion after RDH10 knockdown. Finally,...
Source: Chinese Medical Journal - October 14, 2019 Category: General Medicine Authors: Guan F, Kang Z, Wang L, Wang K, Mao BB, Peng WC, Zhang BL, Lin ZY, Zhang JT, Hu ZQ Tags: Chin Med J (Engl) Source Type: research

Nuclear factor I A promotes temozolomide resistance in glioblastoma via activation of nuclear factor κB pathway
Publication date: Available online 12 October 2019Source: Life SciencesAuthor(s): Xiao Yu, Maode Wang, Jie Zuo, Alafate Wahafu, Ping Mao, Ruichun Li, Wei Wu, Wanfu Xie, Jia WangAbstractAimsTo investigate the underlying mechanism by which glioblastoma (GBM) cells gain temozolomide (TMZ) resistance and to clarify novel therapeutic targets and new prognostic biomarkers for GBM.Main methodsA genome-wide hierarchical bi-clustering based on previously published microarray databases identified Nuclear Factor I A (NFIA) as one of the most significantly upregulated genes correlated to TMZ resistance in GBM. Then, the potential biol...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research

Beyond its antioxidant properties: Quercetin targets multiple signalling pathways in hepatocellular carcinoma in rats
This study was carried out to elucidate the antineoplastic effect of quercetin through regulating both Notch and Hh pathways, apoptosis, cell proliferation and CK2α activity.Main methodsHepatocellular carcinoma was induced in male Sprague Dawley rats by thioacetamide. Quercetin was administered in both protective and curative doses. Parameters of liver function and oxidative stress were assessed. CK2α, Notch and Hh pathways were evaluated using RT-PCR and ELISA. Apoptosis was investigated by detecting caspase-3, caspase-8 and p53. Proliferative and cell cycle markers as cyclin D1 and Ki-67 were detected immunoh...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research

11C-Methionine Integrated PET/MRI-Based Texture Analysis Features May Have a Potential Ability to Distinguish Oligodendroglioma (IDH-Mutant and 1p/19q-Codeleted) From Varied Gliomas
Conclusion11C-Methionine integrated PET/MRI based texture analysis and conventional features may be a promising noninvasive predictor for differentiating the varied gliomas. (Source: Academic Radiology)
Source: Academic Radiology - October 12, 2019 Category: Radiology Source Type: research

GSE138794 A single cell atlas of human glioma
This study sheds light on a long-standing debate regarding lineage relationships among GSCs and presents a paradigm by which personalized combination therapies can be derived from single-cell RNA signatures, to overcome intra-tumor heterogeneity. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 12, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research

GSE138764 miRNA profiling by array of astrocytic tumors
Contributors : Chen-Xue Mao ; Zhao-Qian LiuSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensAstrocytoma is a common pathologic type of glioma, its survival and prognosis remain poor. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - October 12, 2019 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research

Cancers, Vol. 11, Pages 1546: Cerebrospinal Fluid MicroRNA Signatures as Diagnostic Biomarkers in Brain Tumors
In conclusion, we performed the largest study so far focused on CSF miRNA profiling in patients with brain tumors, and we believe that this new class of biomarkers have a strong potential as a diagnostic and prognostic tool in these patients. (Source: Cancers)
Source: Cancers - October 12, 2019 Category: Cancer & Oncology Authors: Alena Kopkova Jiri Sana Tana Machackova Marek Vecera Lenka Radova Karolina Trachtova Vaclav Vybihal Martin Smrcka Tomas Kazda Ondrej Slaby Pavel Fadrus Tags: Article Source Type: research

CXCL13 Is A Biomarker Of Anti-Leucine-Rich Glioma-Inactivated Protein 1 Encephalitis Patients
(Source: Neuropsychiatric Disease and Treatment)
Source: Neuropsychiatric Disease and Treatment - October 11, 2019 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Functional Roles of Long Non-Coding RNAs (LncRNAs) in Glioma Stem Cells.
Authors: Wang L, He Z Abstract Glioma, the most common and aggressive type of brain tumor, has a poor prognosis. Glioma stem cells (GSCs) are thought to be responsible for glioma genesis, proliferation, resistance to chemoradiotherapy, and recurrence. Long non-coding RNAs (lncRNAs) have been viewed as a prospective novel target in glioma therapy in recent years due to their functional roles in GSC biological processes. However, how lncRNAs interact with GSCs and the underlining mechanisms associated with these interactions are not yet clear. In this review, we briefly illustrate recent advancements in the functiona...
Source: Medical Science Monitor - October 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Cancers, Vol. 11, Pages 1537: PATZ1 Is Overexpressed in Pediatric Glial Tumors and Correlates with Worse Event-Free Survival in High-grade Gliomas
o Monica Fedele Glial tumors are the leading cause of cancer-related death and morbidity in children. Their diagnosis, mainly based on clinical and histopathological factors, is particularly challenging because of their high molecular heterogeneity. Thus, tumors with identical histotypes could result in variable biological behaviors and prognoses. The PATZ1 gene has been recently shown to be expressed in adult gliomas, including glioblastomas, where it correlates with the proneural subtype and with a better prognosis. Here, we analyzed the expression of PATZ1 in pediatric gliomas, first at mRNA level in a public data...
Source: Cancers - October 11, 2019 Category: Cancer & Oncology Authors: Annalisa Passariello Maria Elena Errico Vittoria Donofrio Manuela Maestrini Alia Zerbato Laura Cerchia Maria Capasso Mario Capasso Monica Fedele Tags: Article Source Type: research

TRIM44 is indispensable for glioma cell proliferation and cell cycle progression through AKT/p21/p27 signaling pathway
ConclusionTRIM44 was associated with oncogenic potential of glioma. Targeting TRIM44 might be beneficial for glioma therapy. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - October 11, 2019 Category: Cancer & Oncology Source Type: research

The Pan-Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA.
Stephens PJ, Zhu VW, Ou SI, Lovly CM, Gounder M, Schrock AB, Ross JS, Miller VA, Klempner SJ, Ali SM Abstract PURPOSE: Amplifications of receptor tyrosine kinases (RTKS) are therapeutic targets in multiple tumor types (e.g. HER2 in breast cancer), and amplification of the chromosome 4 segment harboring the three RTKs KIT, PDGFRA, and KDR (4q12amp) may be similarly targetable. The presence of 4q12amp has been sporadically reported in small tumor specific series but a large-scale analysis is lacking. We assess the pan-cancer landscape of 4q12amp and provide early clinical support for the feasibility of targeting th...
Source: The Oncologist - October 11, 2019 Category: Cancer & Oncology Authors: Disel U, Madison R, Abhishek K, Chung JH, Trabucco SE, Matos AO, Frampton GM, Albacker LA, Reddy V, Karadurmus N, Benson A, Webster J, Paydas S, Cabanillas R, Nangia C, Ozturk MA, Millis SZ, Pal SK, Wilky B, Sokol ES, Gay LM, Soman S, Ganesan S, Janeway K Tags: Oncologist Source Type: research

Development and validation of single field multi-ion particle therapy treatments.
i A Abstract PURPOSE: To develop and validate combined ion-beam with constant RBE (CICR) particle therapy in single field arrangements for improved treatment efficacy, robustness and normal tissue sparing. METHODS: The PRECISE (PaRticle thErapy using single and Combined Ion optimization StratEgies) treatment planning system (TPS) was developed to investigate clinical viability of CICR treatments. Single-field uniform dose (SFUD) with a single ion (p, He, or C) and CICR (C-p and C-He) treatments were generated for three patient cases with a clinically prescribed dose of 3 Gy(RBE) per fraction. Spread-out Bragg...
Source: Physics in Medicine and Biology - October 11, 2019 Category: Physics Authors: Kopp B, Mein S, Dokic I, Harrabi S, Böhlen TT, Haberer T, Debus J, Abdollahi A, Mairani A Tags: Int J Radiat Oncol Biol Phys Source Type: research

Diffuse intrinsic pontine glioma: molecular landscape and emerging therapeutic targets
Purpose of review Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brainstem malignancy. Despite advances in understanding of the molecular underpinnings of the tumor in the past decade, the dismal prognosis of DIPG has thus far remained unchanged. This review seeks to highlight promising therapeutic targets within three arenas: DIPG cell-intrinsic vulnerabilities, immunotherapeutic approaches to tumor clearance, and microenvironmental dependencies that promote tumor growth. Recent findings Promising therapeutic strategies from recent studies include epigenetic modifying agents such as histone deacetylase ...
Source: Current Opinion in Oncology - October 10, 2019 Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

Palliative care in glioma management
Purpose of review The concept of palliative care is becoming increasingly important in the management of glioma patients. However, the right time for implementation, as well as the individual degree of integration of palliative care aspects, are still a matter of debate. This review updates recent evidence of palliative care in glioma and raises questions for future developments. Recent findings According to the disease-specific aspects of palliative care in glioma management, there is an increasing need for a specialized ‘neurooncological’ palliative care approach. The implementation of palliative care f...
Source: Current Opinion in Oncology - October 10, 2019 Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

Neurological malignancies in neurofibromatosis type 1
Purpose of review The current review summarizes recent advances on three important issues in neurofibromatosis type 1 (NF1) management: the identification of specific NF1 gene mutations predicting the risk for developing neurological malignancies; the molecular features of NF1-associated tumors and their differences from sporadic neoplasms; genetic, epigenetic, or microenviromental factors leading benign tumors to a malignant transformation in NF1. Recent findings The association between the risk of developing optic pathway glioma and specific germiline NF1 mutations is still debated and further studies are needed wit...
Source: Current Opinion in Oncology - October 10, 2019 Category: Cancer & Oncology Tags: BRAIN AND NERVOUS SYSTEM: Edited by Marc Sanson Source Type: research

Efficient separation of tumor cells from untreated whole blood using a novel multistage hydrodynamic focusing microfluidics.
Abstract Significant progress on circulating tumor cells (CTCs) has profound impact for noninvasive tumor profiling including early diagnosis, treatment monitoring, and metastasis recognition. Therefore, CTCs based liquid biopsy technology is taking a rapid growth in the field of precision oncology. The label-free approaches relied on microfluidic chip stand out from a crowd of methods that suffer from time consuming, extensive blood samples, lost target cells and labor-intensive operation. In this paper, a label-free separation microfluidic device was developed using multistage channel, which took full advantage ...
Source: Talanta - October 10, 2019 Category: Chemistry Authors: Gao R, Cheng L, Wang S, Bi X, Wang X, Wang R, Chen X, Zha Z, Wang F, Xu X, Zhao G, Yu L Tags: Talanta Source Type: research

Prognostic Implications of the Complement Protein C1q in Gliomas
The contribution of the complement system in the pathophysiology of brain cancers has been recently considered in light of its well-known involvement in carcinogenesis. Complement system represents an important component of the inflammatory response, which acts as a functional bridge between the innate and adaptive immune response. C1q, the first recognition subcomponent of the complement classical pathway, has recently been shown to be involved in a range of pathophysiological functions that are not dependent on complement activation. C1q is expressed in the microenvironment of various types of human tumors, including mel...
Source: Frontiers in Immunology - October 10, 2019 Category: Allergy & Immunology Source Type: research

13 N-NH 3 PET/CT in oncological disease
Abstract13N-Ammonia (13N-NH3) is widely used positron emission tomography/computed tomography (PET/CT) radiotracer for the measurement of myocardial blood perfusion; the possible role of13N-NH3 PET or PET/CT in oncological disease is not yet clear. Aim of this review is to evaluate the diagnostic performances of13N-NH3 PET in this field. A comprehensive computer literature search of the PubMed/MEDLINE, Scopus, and Embase databases was conducted including articles up to June 2019. Eighteen articles were finally included in the review. From the analyses of the selected studies, the following main findings could be drawn: (1)...
Source: Japanese Journal of Radiology - October 10, 2019 Category: Radiology Source Type: research

Patient Involvement in the Design of a Randomised Trial of Proton Beam Radiotherapy Versus Standard Radiotherapy for Good Prognosis Glioma
UK neuro-oncologists and multidisciplinary colleagues are developing a trial for patients with good prognosis glioma comparing quality of life (QOL) and the long-term effects of radiotherapy between patients treated with proton beam therapy (PBT) and modern, state of the art image-guided intensity-modulated photon radiotherapy (IMRT). Patients with glioma differ in important ways from other oncology patients and this may have important implications for this and other studies. Patients frequently report symptoms including headaches, seizures, personality and memory changes and often have complex neurological deficits affect...
Source: Clinical Oncology - October 10, 2019 Category: Radiology Authors: J.R. Powell, L. Murray, N.G. Burnet, S. Fernandez, Z. Lingard, L. McParland, D.J. O'Hara, G.A. Whitfield, S.C. Short Tags: Editorial Source Type: research

Cancers, Vol. 11, Pages 1518: A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth
i Infante Di Marcotullio : Pharmacological Hedgehog (Hh) pathway inhibition has emerged as a valuable anticancer strategy. A number of small molecules able to block the pathway at the upstream receptor Smoothened (Smo) or the downstream effector glioma-associated oncogene 1 (Gli1) has been designed and developed. In a recent study, we exploited the high versatility of the natural isoflavone scaffold for targeting the Hh signaling pathway at multiple levels showing that the simultaneous targeting of Smo and Gli1 provided synergistic Hh pathway inhibition stronger than single administration. This approach seems to ...
Source: Cancers - October 9, 2019 Category: Cancer & Oncology Authors: Lospinoso Severini Quaglio Basili Ghirga Bufalieri Caimano Balducci Moretti Romeo Loricchio Maroder Botta Mori Infante Di Marcotullio Tags: Article Source Type: research

Immunotherapy Against Gliomas: is the Breakthrough Near?
AbstractImmunotherapeutic approaches have been, and continue to be, aggressively investigated in the treatment of infiltrating gliomas. While the results of late-phase clinical studies have been disappointing in this disease space thus far, the success of immunotherapies in other malignancies as well as the incremental gains in our understanding of immune-tumour interactions in gliomas has fuelled a strong continued interest of their evaluation in these tumours. We discuss a range of immunotherapeutic approaches including, but not limited to, vaccines, checkpoint inhibitors, oncolytic viruses, and gene therapies. Potential...
Source: Drugs - October 9, 2019 Category: Drugs & Pharmacology Source Type: research

Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta ‐analysis
ConclusionOur results indicate that increased circulating IL ‐6, IL‐8, IL‐17, TNF‐α, TGF ‐β, and CRP levels are significantly associated with increased glioma risk. Moreover, our meta ‐analysis suggests that circulating IL‐6 and CRP may serve as powerful biomarkers for a poor prognosis in glioma patients. (Source: Cancer Medicine)
Source: Cancer Medicine - October 9, 2019 Category: Cancer & Oncology Authors: Yuan Feng, Jia Wang, Dezhong Tan, Peng Cheng, Anhua Wu Tags: ORIGINAL RESEARCH Source Type: research

Novel small molecule protein kinase CK2 inhibitors exert potent antitumor effects on T98G and SEGA cells in vitro.
In conclusion, CK2 appears to play a role not only in malignant glioma cells but it can also sustain the viability and proliferation of benign astrocytoma cells. The obtained antitumor effects of CK2 inhibitors significantly exceeded their mild or no effect on normal astrocytes in control, which supports the therapeutic potential of these compounds against gliomas. PMID: 31588710 [PubMed - in process] (Source: Folia Neuropathologica)
Source: Folia Neuropathologica - October 8, 2019 Category: Neurology Tags: Folia Neuropathol Source Type: research

CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma
Cancer Gene Therapy, Published online: 08 October 2019; doi:10.1038/s41417-019-0140-8CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - October 8, 2019 Category: Cancer & Oncology Authors: Luqing Tong Jiabo Li John Choi Ayush Pant Yuanxuan Xia Christopher Jackson Peidong Liu Li Yi Elias Boussouf Michael Lim Xuejun Yang Source Type: research

A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration
(Source: Acta Neuropathologica)
Source: Acta Neuropathologica - October 8, 2019 Category: Neurology Source Type: research

Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making [FUNCTIONAL]
Background and Purpose Fractional tumor burden better correlates with histologic tumor volume fraction in treated glioblastoma than other perfusion metrics such as relative CBV. We defined fractional tumor burden classes with low and high blood volume to distinguish tumor from treatment effect and to determine whether fractional tumor burden can inform treatment-related decision-making. Materials and Methods Forty-seven patients with high-grade gliomas (primarily glioblastoma) with recurrent contrast-enhancing lesions on DSC-MR imaging were retrospectively evaluated after surgical sampling. Histopathologic examination def...
Source: American Journal of Neuroradiology - October 8, 2019 Category: Radiology Authors: Iv, M., Liu, X., Lavezo, J., Gentles, A. J., Ghanem, R., Lummus, S., Born, D. E., Soltys, S. G., Nagpal, S., Thomas, R., Recht, L., Fischbein, N. Tags: FUNCTIONAL Source Type: research

NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells
AbstractNa+/H+ exchanger 5 (NHE5) is enriched in neurons and cycles between recycling endosomes and plasma membranes and transports protons to the endosomal lumen as well as to the extracellular space. Although NHE5 expression is undetectable in normal astrocytes, C6 glioma cells express NHE5 at an elevated level. Using C6 cells as a model, here we demonstrate that NHE5 has an important role in tumor growth and tumor cell proliferation and invasion. Glioma xenografts originating fromNHE5-knockdown cells exhibited significantly slower growth than those fromNHE1-knockdown cells and control cells. Histological characterizatio...
Source: Clinical and Experimental Metastasis - October 8, 2019 Category: Cancer & Oncology Source Type: research

The polymorphisms (rs3213801 and rs5744533) of DNA polymerase kappa gene are not related with glioma risk and prognosis: A case ‐control study
In this study, we found DNA polymerase kappa variants rs3213801 and rs5744533 are not associated with glioma risk and prognosis, but they are likely to be associated with certain glioma characteristics, such as age and World Health Organization grade. Meanwhile, the age, surgery types, and chemotherapy could be independent prognostic factors in glioma. AbstractDNA polymerase kappa (POLK), one of the specialized Y family DNA polymerases, functions in translesion synthesis and is suggested to be related with cancers. Single nucleotide polymorphisms (SNPs) in specialized DNA polymerases have been demonstrated to be associated...
Source: Cancer Medicine - October 8, 2019 Category: Cancer & Oncology Authors: Ying Wu, Linghui Zhou, Yujiao Deng, Na Li, Pengtao Yang, Shanshan Dong, Si Yang, Yi Zheng, Li Yao, Ming Zhang, Zhen Zhai, Zhijun Dai, Yuan Wu Tags: ORIGINAL RESEARCH Source Type: research

The long non-coding RNA, urothelial carcinoma associated 1, promotes cell growth, invasion, migration, and chemo-resistance in glioma through Wnt/ β-catenin signaling pathway.
This study investigated the functional role of UCA1 in glioma and explored the underlying molecular mechanisms. UCA1 was found to be highly up-regulated in glioma cells, and knock-down of UCA1 inhibited cell growth, invasion and migration, and also induced apoptosis in glioma cells. On the other hand, overexpression of UCA1 promoted cell proliferation, cell invasion and migration in glioma cells. Knock-down of UCA1 suppressed the activity of Wnt/β-catenin signaling, and treatment with lithium chloride restored the inhibitory effect of UCA1 knock-down on cell invasion and migration. More importantly, the aberrant expre...
Source: Aging - October 8, 2019 Category: Biomedical Science Authors: Zhang B, Fang S, Cheng Y, Zhou C, Deng F Tags: Aging (Albany NY) Source Type: research

Association Between Genetic Polymorphisms In TYMS And Glioma Risk In Chinese Patients: A Case-Control Study
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - October 7, 2019 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research

ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma
Cell Death & Disease, Published online: 07 October 2019; doi:10.1038/s41419-019-1986-2ACT001, a novel PAI-1 inhibitor, exerts synergistic effects in combination with cisplatin by inhibiting PI3K/AKT pathway in glioma (Source: Cell death and disease)
Source: Cell death and disease - October 7, 2019 Category: Internal Medicine Authors: Xiaonan Xi Ning Liu Qianqian Wang Yahui Chu Zheng Yin Yahui Ding Yaxin Lu Source Type: research

MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway
Oncogene, Published online: 07 October 2019; doi:10.1038/s41388-019-1045-6MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway (Source: Oncogene)
Source: Oncogene - October 7, 2019 Category: Cancer & Oncology Authors: Wei Yang Yanyan Li Ruoling Gao Zenghe Xiu Ting Sun Source Type: research

Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation.
Abstract BACKGROUND: Tumor recurrence after orthotopic liver transplantation (OLT) remains a serious threat for long-term survival of the recipients with hepatocellular carcinoma (HCC), since very few factors or measures have shown impact on overcoming HCC recurrence after OLT. Postoperative infection suppresses tumor recurrence and improves patient survival in lung cancer and malignant glioma probably via stimulating the immune system. Post-transplant infection (PTI), a common complication, is deemed to be harmful for the liver transplant recipients from a short-term perspective. Nevertheless, whether PTI inhibit...
Source: World Journal of Gastroenterology : WJG - October 7, 2019 Category: Gastroenterology Authors: Chao JS, Zhao SL, Ou-Yang SW, Qian YB, Liu AQ, Tang HM, Zhong L, Peng ZH, Xu JM, Sun HC Tags: World J Gastroenterol Source Type: research

PCC0208017, a novel small-molecule inhibitor of MARK3/MARK4, suppresses glioma progression in vitro and in vivo
Publication date: Available online 18 September 2019Source: Acta Pharmaceutica Sinica BAuthor(s): Fangfang Li, Zongliang Liu, Heyuan Sun, Chunmei Li, Wenyan Wang, Liang Ye, Chunhong Yan, Jingwei Tian, Hongbo WangAbstractGliomas are the most common primary intracranial neoplasms among all brain malignancies, and the microtubule affinity regulating kinases (MARKs) have become potential drug targets for glioma. Here, we report a novel dual small-molecule inhibitor of MARK3 and MARK4, designated as PCC0208017. In vitro, PCC0208017 strongly inhibited kinase activity against MARK3 and MARK4, and strongly reduced proliferati...
Source: Acta Pharmaceutica Sinica B - October 6, 2019 Category: Cancer & Oncology Source Type: research

One-day protocol for 18F-FDG and 13N-ammonia PET/CT with uptake decoupling score in differentiating untreated low-grade glioma from inflammation
Conclusions18F-FDG/13N-ammonia uptake decoupling score can be used to discriminate between LGGs and BILs. Use of a decoupling map of these two tracers can improve visual analysis and diagnostic accuracy.ResumenPropósitoLa identificación precisa de los gliomas de bajo grado (LGGs; grados I y II de la Organización Mundial de la Salud) y su diferenciación de las lesiones por inflamación cerebral (BILs) sigue siendo difícil; sin embargo, es esencial para el tratamiento. Este estudio evaluó si un protocolo de un día para la TEP/TC con amoníaco 18F-FDG y 13Namon&iacu...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - October 6, 2019 Category: Nuclear Medicine Source Type: research

Are low-grade gliomas of mesial temporal area alone?
Conclusion: Mesial temporal LGGs are not alone and a high proportion of temporal neocortex appeared normal on preoperative MRI, may contain dual pathology. Thus, anterior temporal resection should be performed to have satisfactory seizure and oncological outcomes. PMID: 31583167 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - October 6, 2019 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma.
Conclusion: Although cases of concurrent glioma and MS remain rare, we present a case illustrating this phenomenon and explore a number of theories behind a potential causal relationship. PMID: 31583163 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - October 6, 2019 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
This article provides a brief discussion of the major 2016 updates to the WHO CNS classification scheme and reviews typical MR imaging findings of adult primary CNS neoplasms, including diffuse infiltrating gliomas, ependymal tumors, neuronal/glioneuronal tumors, pineal gland tumors, meningiomas, nerve sheath tumors, solitary fibrous tumors, and lymphoma. PMID: 31582041 [PubMed - in process] (Source: Radiologic Clinics of North America)
Source: Radiologic Clinics of North America - October 5, 2019 Category: Radiology Authors: Wang KY, Chen MM, Malayil Lincoln CM Tags: Radiol Clin North Am Source Type: research