Classifying glioma via liquid biopsy--progress towards an unmet clinical need
Clin Cancer Res. 2024 Apr 23. doi: 10.1158/1078-0432.CCR-24-0423. Online ahead of print.ABSTRACTThe diagnosis and classification of glioma by liquid biopsy represents a critical unmet need in neuro oncology. A recent study demonstrates targeted next generation sequencing (NGS) of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) as an evolving option for liquid biopsy in patients with glioma.PMID:38652677 | DOI:10.1158/1078-0432.CCR-24-0423 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Kalil G Abdullah Source Type: research
Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with comple... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Katerina Dvorakova, Veronika Skarkova, Barbora Vitovcova, Jiri Soukup, Hana Vosmikova, Zuzana Pleskacova, Adam Skarka, Michael Christian Bartos, Petr Krupa, Petra Kasparova, Jiri Petera and Emil Rudolf Tags: Research Source Type: research
Suberanilohydroxamic acid (SAHA), a HDAC inhibitor, suppresses the effect of Treg cells by targeting the c-Myc/CCL1 pathway in glioma stem cells and improves PD-L1 blockade therapy
ConclusionSAHA inhibited the binding of c-Myc with the CCL1 promoter and then suppressed the transcription of CCL1.Additionally, it effectively blocked the interplay of CCL1-CCR8, resulting in reduced activity of Tregs and alleviation of tumor immunosuppression. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Mesenchymal stem cells as therapeutic vehicles for glioma
Cancer Gene Therapy, Published online: 23 April 2024; doi:10.1038/s41417-024-00775-7Mesenchymal stem cells as therapeutic vehicles for glioma (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Tomoya Oishi Shinichiro Koizumi Kazuhiko Kurozumi Source Type: research
Anti-cancer potential of zerumbone in cancer and glioma: current trends and future perspectives
AbstractPlant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component ofZingiber zerumbet rhizomes, has been examined for its wide-spectrum in the treatment of multi-targeted diseases. The rhizomes have been used as food flavoring agents in numerous cuisines and in flora medication. Numerous in vivo and in vitro experiments have prepared confirmation of ZER as a potent immunomodulator as well as a potential...
Source: Medical Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1594: Endovascular Applications for the Management of High-Grade Gliomas in the Modern Era
Aziz-Sultan
Joshua D. Bernstock
High-grade gliomas (HGGs) have a poor prognosis and are difficult to treat. This review examines the evolving landscape of endovascular therapies for HGGs. Recent advances in endovascular catheter technology and delivery methods allow for super-selective intra-arterial cerebral infusion (SSIACI) with increasing precision. This treatment modality may offer the ability to deliver anti-tumoral therapies directly to tumor regions while minimizing systemic toxicity. However, challenges persist, including blood–brain barrier (BBB) penetration, hemodynamic complexities, and drug...
Source: Cancers - April 22, 2024 Category: Cancer & Oncology Authors: Ari D. Kappel Rohan Jha Saibaba Guggilapu William J. Smith Abdullah H. Feroze Adam A. Dmytriw Juan Vicenty-Padilla Rodolfo E. Alcedo Guardia Florian A. Gessler Nirav J. Patel Rose Du Alfred P. See Pier Paolo Peruzzi Mohammad A. Aziz-Sultan Joshua D. Berns Tags: Review Source Type: research
A comparison study of dynamic [18F]Alfatide II imaging and [11C]MET in orthotopic rat models of glioblastoma
Conclusion[18F]Alfatide II demonstrates potential in imaging tumor-associated neovascularization in the context of glioblastoma multiforme (GBM), suggesting its utility as a tool for further exploration in neovascular characterization. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
Dosimetric comparison of advanced radiation techniques for scalp-sparing in low-grade gliomas
ConclusionOur study provides evidence that the SO approach is a feasible technique for reducing scalp radiation dose. However, it is imperative to conduct prospective trials to assess the benefits associated with this approach. (Source: Strahlentherapie und Onkologie)
Source: Strahlentherapie und Onkologie - April 22, 2024 Category: Cancer & Oncology Source Type: research
Identifying key factors for predicting O6-Methylguanine-DNA methyltransferase status in adult patients with diffuse glioma: a multimodal analysis of demographics, radiomics, and MRI by variable Vision Transformer
ConclusionThe vViT is a competent deep learning model in predicting MGMT status. The ED radiomic features of the T2-weighted image demonstrated the most dominant contribution. (Source: Neuroradiology)
Source: Neuroradiology - April 20, 2024 Category: Radiology Source Type: research
Cancers, Vol. 16, Pages 1579: High-Grade Glioma Recurrence Is Delayed in Hispanic Patients despite Severe Social Vulnerability: A Retrospective Cohort Study
Agarwal
High-grade gliomas (HGGs; WHO grade III or IV) are the most common and lethal brain malignancy. Patients of Hispanic ethnicity are diagnosed with HGGs earlier than non-Hispanic patients, but they exhibit improved HGG survival following diagnosis. Either environmental or biological factors could explain this survival benefit. We aimed to determine if post-diagnosis advantages would still be present in Hispanic patients with high social vulnerability, an environmental condition predisposing patients to poor oncologic outcomes. HGG outcomes were retrospectively assessed in a cohort of 22 Hispanic patients and 33 n...
Source: Cancers - April 20, 2024 Category: Cancer & Oncology Authors: Joshua A. Reynolds Isabella L. Pecorari Alexander Ledet Vijay Agarwal Tags: Article Source Type: research
A novel network-based method identifies a cuproplasia-related pan-cancer gene signature to predict patient outcome
AbstractCopper is a vital micronutrient involved in many biological processes and is an essential component of tumour cell growth and migration. Copper influences tumour growth through a process called cuproplasia, defined as abnormal copper-dependent cell-growth and proliferation. Copper-chelation therapy targeting this process has demonstrated efficacy in several clinical trials against cancer. While the molecular pathways associated with cuproplasia are partially known, genetic heterogeneity across different cancer types has limited the understanding of how cuproplasia impacts patient survival. Utilising RNA-sequencing ...
Source: Human Genetics - April 20, 2024 Category: Genetics & Stem Cells Source Type: research
GLI1+ Cells Contribute to Vascular Remodeling in Pulmonary Hypertension
CONCLUSIONS: Our data highlight GLI1+ cells as an alternative cellular source of VSMCs in pulmonary hypertension and suggest that these cells and the associated signaling pathways represent an important therapeutic target for further studies.PMID:38639105 | DOI:10.1161/CIRCRESAHA.123.323736 (Source: Cell Research)
Source: Cell Research - April 19, 2024 Category: Cytology Authors: Xuran Chu Vahid Kheirollahi Arun Lingampally Prakash Chelladurai Chanil Valasarajan Ana Ivonne Vazquez-Armendariz Stefan Hadzic Ali Khadim Oleg Pak Stefano Rivetti Jochen Wilhelm Marek Bartkuhn Slaven Crnkovic Alena Moiseenko Monika Heiner Simone Kraut Le Source Type: research
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis
CONCLUSION: The prognostic risk model can effectively classify patients with glioblastoma into high-risk and low-risk groups in terms of overall survival rate, which may help select high-risk patients with glioblastoma for more intensive treatment.PMID:38639614 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Jieying Wen Haojie Zheng Xi Yuan Cuilan Huang Xiaogang Yang Zhiying Lin Guanglong Huang Source Type: research
Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner
Transl Oncol. 2024 Apr 18;45:101956. doi: 10.1016/j.tranon.2024.101956. Online ahead of print.ABSTRACTTumor Treating Fields (TTFields) extend the survival of glioblastoma (GBM) patients by interfering with a broad range of tumor cellular processes. Among these, TTFields disrupt primary cilia stability on GBM cells. Here we asked if concomitant treatment of TTFields with other agents that interfere with GBM ciliogenesis further suppress GBM cell proliferation in vitro. Aurora kinase A (AURKA) promotes both cilia disassembly and GBM growth. Inhibitors of AURKA, such as Alisertib, inhibit cilia disassembly and increase ciliar...
Source: Translational Oncology - April 19, 2024 Category: Cancer & Oncology Authors: Jia Tian Julianne C Mallinger Ping Shi Dahao Ling Loic P Deleyrolle Min Lin Habibeh Khoshbouei Matthew R Sarkisian Source Type: research
Identification of Prognostic Markers of Glioblastoma through Bioinformatics Analysis
CONCLUSION: The prognostic risk model can effectively classify patients with glioblastoma into high-risk and low-risk groups in terms of overall survival rate, which may help select high-risk patients with glioblastoma for more intensive treatment.PMID:38639614 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 19, 2024 Category: Complementary Medicine Authors: Jieying Wen Haojie Zheng Xi Yuan Cuilan Huang Xiaogang Yang Zhiying Lin Guanglong Huang Source Type: research
