The Role of Incomplete Pregnancies in Ovarian Cancer Risk The Role of Incomplete Pregnancies in Ovarian Cancer Risk
A new analysis examines the potential role incomplete pregnancies may have in the risk for developing ovarian cancer. Is there a link?Journal of the National Cancer Institute (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 13, 2021 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Ovarian Cancer Diagnosis Can Take Big Toll on Women ’ s Mental Health
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 12, 2021 Category: Cancer & Oncology Tags: Oncology, Psychiatry, News, Source Type: news

Latest KCIC Report Finds Decline in Mesothelioma Lawsuits
The number of mesothelioma lawsuits filed in 2020 dropped significantly, while cases involving lung cancer continued to increase, according to a recent study reflecting the changing face of asbestos litigation. KCIC, a well-respected consulting firm in Washington, D.C., that manages asbestos product liabilities, released its industry report Thursday. Asbestos legal filings, covering both malignant and nonmalignant disease in the United States, dropped 11% from 2019 to 2020, from 4,137 to 3,685 cases, respectively. Most prominently, there was a 9% increase in asbestos-related lung cancer filings, but a 14% decrease...
Source: Asbestos and Mesothelioma News - April 12, 2021 Category: Environmental Health Authors: Amy Edel Source Type: news

Ovarian Cancer Diagnosis Can Take Big Toll on Women's Mental Health
MONDAY, April 12, 2021 -- Ovarian cancer is a tough diagnosis to cope with, and now a new study finds these patients face a much higher risk of depression and other mental health issues. And the emotional anguish exacted a significant toll: The... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 12, 2021 Category: General Medicine Source Type: news

Urinary Incontinence Surgery Won't Raise a Woman's Cancer Risk
NDAY, April 12, 2021 -- Women face no increased risk of pelvic cancer -- tumors of the bladder, cervix and ovaries -- if they have surgery to treat stress urinary incontinence (SUI), a new study finds. Concerns about possible complications and... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 12, 2021 Category: General Medicine Source Type: news

Ovarian Cancer Diagnosis Can Take Big Toll on Women's Mental Health
Title: Ovarian Cancer Diagnosis Can Take Big Toll on Women's Mental HealthCategory: Health NewsCreated: 4/12/2021 12:00:00 AMLast Editorial Review: 4/12/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 12, 2021 Category: Cancer & Oncology Source Type: news

MD Anderson researchers highlight advances in clinical studies at the AACR Annual Meeting 2021
(University of Texas M. D. Anderson Cancer Center) Researchers at The University of Texas MD Anderson Cancer Center conducted early phase clinical trials that showed promising results for patients with RET fusion-positive cancers, high-grade and low-grade glioma and ovarian cancer. The results for these studies will be presented at the AACR Annual Meeting 2021. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2021 Category: Cancer & Oncology Source Type: news

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors
Mutations in the BRCA1 or BRCA2 tumor suppressor genes predispose individuals to breast and ovarian cancer. In the clinic, these cancers are treated with inhibitors that target poly(ADP-ribose) polymerase (PARP). We show that inhibition of DNPH1, a protein that eliminates cytotoxic nucleotide 5-hydroxymethyl-deoxyuridine (hmdU) monophosphate, potentiates the sensitivity of BRCA-deficient cells to PARP inhibitors (PARPi). Synthetic lethality was mediated by the action of SMUG1 glycosylase on genomic hmdU, leading to PARP trapping, replication fork collapse, DNA break formation, and apoptosis. BRCA1-deficient cells that acqu...
Source: ScienceNOW - April 8, 2021 Category: Science Authors: Fugger, K., Bajrami, I., Silva Dos Santos, M., Young, S. J., Kunzelmann, S., Kelly, G., Hewitt, G., Patel, H., Goldstone, R., Carell, T., Boulton, S. J., MacRae, J., Taylor, I. A., West, S. C. Tags: Medicine, Diseases, Molecular Biology r-articles Source Type: news

Cancer discovery could revive failed treatments for solid tumors
(University of Virginia Health System) New research could rescue once-promising immunotherapies for treating solid cancer tumors, such as ovarian, colon and triple-negative breast cancer, that ultimately failed in human clinical trials. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 6, 2021 Category: Cancer & Oncology Source Type: news

End-of-life care remains aggressive for people with ovarian cancer
(Michigan Medicine - University of Michigan) People with ovarian cancer frequently receive aggressive end-of-life care despite industry guidelines that emphasize quality of life for those with advanced disease, according to a recent study. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 5, 2021 Category: Cancer & Oncology Source Type: news

Cytoreduction in Advanced Ovarian Cancer:'Keep the Status Quo'Cytoreduction in Advanced Ovarian Cancer:'Keep the Status Quo '
A retrospective case-control study showed that optimal cytoreductive surgery is an independent predictor of overall survival, even when controlling for response to chemotherapy.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 30, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Drug Boosts Survival for Women With Advanced Ovarian Cancer
Title: Drug Boosts Survival for Women With Advanced Ovarian CancerCategory: Health NewsCreated: 3/25/2021 12:00:00 AMLast Editorial Review: 3/26/2021 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - March 26, 2021 Category: Cancer & Oncology Source Type: news

Drug Boosts Survival for Women With Advanced Ovarian Cancer
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - March 25, 2021 Category: Cancer & Oncology Tags: Oncology, News, Source Type: news

Drug Boosts Survival for Women With Advanced Ovarian Cancer
THURSDAY, March 25, 2021 -- Women with advanced ovarian cancer often face grim statistics, with less than half surviving for five years after their diagnosis. However, a new study suggests that so-called " maintenance therapy " with a targeted cancer... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 25, 2021 Category: General Medicine Source Type: news

Olaparib Boosts Survival for Women With Advanced Ovarian Cancer
THURSDAY, March 25, 2021 -- Women with advanced ovarian cancer often face grim statistics, with less than half surviving for five years after their diagnosis. However, a new study suggests that so-called " maintenance therapy " with a targeted cancer... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - March 25, 2021 Category: General Medicine Source Type: news

Potential COVID-19 treatment identified in UCLA-led lab study
This study identified a new potential therapy that could help the global fight against COVID-19 and support populations that have been disproportionately affected by this deadly disease.”Drugs are categorized as small molecules when their individual molecules are tiny enough that they can penetrate to where they are needed. The researchers screened 430 drugs from among the approximately 200,000 compounds in CNSI ’sMolecular Screening Shared Resource libraries. They identified 34  that demonstrated at least some ability to halt the coronavirus, and eight that did so at relatively lower doses, before zeroing...
Source: UCLA Newsroom: Health Sciences - March 24, 2021 Category: Universities & Medical Training Source Type: news

Why 2020 was the year of marvellous medicine
A vaccine that could treat multiple types of tumours and stop the cancer from returning has been created in Australia. It could be used against breast, lung, ovarian, kidney and pancreatic cancers. (Source: the Mail online | Health)
Source: the Mail online | Health - March 23, 2021 Category: Consumer Health News Source Type: news

Rock Musician Turned Med Student Takes Aim at Ovarian Cancer Rock Musician Turned Med Student Takes Aim at Ovarian Cancer
Tragedy, luck, and perseverance took Stephen Harris from world tours with The Cult and Guns N'Roses to becoming a climbing instructor, going to medical school, and now helping those with ovarian cancer.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 22, 2021 Category: Consumer Health News Tags: Med Students News Source Type: news

A leap forward in research on CAR T cell therapy
(University of Helsinki) A study recently published in the journal Science looked into how CAR T immunotherapy could be used to treat solid tumours in addition to leukaemias. The programming of CAR T cells opens avenues for applying cell therapies to, for example, breast cancer or ovarian cancer in the future. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 18, 2021 Category: Cancer & Oncology Source Type: news

Cancer symptoms: Persistent bloating could be a sign of ovarian cancer
CANCER is a scary word, no matter which body part it affects. Women are at real risk of a tumour growing in their ovaries and fallopian tubes. If this disease isn't caught early, there's a real possibility it could go elsewhere. (Source: Daily Express - Health)
Source: Daily Express - Health - March 14, 2021 Category: Consumer Health News Source Type: news

Are women over 70 dying from ovarian cancer... as a tragic result of ageism?
The over-70s face an average delay of five months before being referred to specialists, according to data collected by Ovarian Cancer Action - twice as long as the wait faced by younger women. (Source: the Mail online | Health)
Source: the Mail online | Health - March 13, 2021 Category: Consumer Health News Source Type: news

Genetic Testing for Breast and Ovarian Cancer Genetic Testing for Breast and Ovarian Cancer
A large, retrospective study shows how germline genetic testing has evolved over time in women with breast cancer or ovarian cancer -- reveals a path forward for testing these patients.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - March 9, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Oncotarget: Sensitivity testing on ovarian cancer cells isolated from malignant ascites
(Impact Journals LLC) The aim of this @Oncotarget study is to determine whether tumor cells isolated from ascites of EOC patients can be used to determine chemotherapy sensitivity by using in vitro proliferation assays (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 8, 2021 Category: Cancer & Oncology Source Type: news

Ovarian Cancer Prevention: How Patients Decide on Surgery Ovarian Cancer Prevention: How Patients Decide on Surgery
Patients consider the risk of cancer and menopause, as well as other factors, when making decisions about ovarian cancer prevention surgery, according to a small study.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - March 5, 2021 Category: Surgery Tags: Hematology-Oncology News Source Type: news

Biocon Biologics, Viatris Inc. get CHMP nod for Abevmy, a biosimilar to Avastin
Abevmy is abiosimilar to Roche's Avastin, prescribed for all indications including metastatic colorectal carcinoma, metastatic breast cancer, non-small-cell lung carcinoma, glioblastoma, ovarian, cervical and renal cancer as part of a specific regimen, it said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - March 1, 2021 Category: Pharmaceuticals Source Type: news

UAMS Professor Awarded $900K Ovarian Cancer Research Grant
UAMS Professor Martin Cannon has been awarded a $900,000 Ovarian Cancer Research Alliance grant to study dendritic cell vaccination against ovarian cancer. (Source: Arkansas Business - Health Care)
Source: Arkansas Business - Health Care - February 25, 2021 Category: American Health Source Type: news

Johnson & Johnson Preparing $3.9 Billion for Talc Settlements
Pharmaceutical giant Johnson & Johnson has set aside $3.9 billion for talc-related litigation, according to a regulatory filing this week with the Securities and Exchange Commission in Washington D.C. The company said it’s now facing more than 25,000 lawsuits related to various talc products that have allegedly caused cancers, primarily from asbestos fiber contamination. The $3.9 billion is almost double the amount that Johnson & Johnson reported being set aside for litigation expenses in its 2020 fiscal year-end results. A Missouri Court of Appeals earlier last year upheld a lower-court ruling, but reduced t...
Source: Asbestos and Mesothelioma News - February 24, 2021 Category: Environmental Health Authors: Amy Edel Source Type: news

Pap Test/Cervical Swab Samples Reveal Ovarian Cancer Biomarkers Pap Test/Cervical Swab Samples Reveal Ovarian Cancer Biomarkers
Residual fixatives from liquid-based Pap tests and cervical swabs contain tumor-specific biomarkers for ovarian cancer, according to an analysis of proteins found in matched biospecimens.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 24, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Mayo Clinic researchers develop test to measure effect of breast cancer gene variants
(Mayo Clinic) Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were published today in a study in theAmerican Journal of Human Genetics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 19, 2021 Category: Cancer & Oncology Source Type: news

Mayo Clinic researchers develop test to measure effect of breast cancer gene variants
ROCHESTER, Minn. ? Researchers at Mayo Clinic have combined results from a functional test measuring the effect of inherited variants in the BRCA2 breast and ovarian cancer gene with clinical information from women who received genetic testing to determine the clinical importance of many BRCA2 variants of uncertain significance (VUS). The findings were published today [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - February 19, 2021 Category: Databases & Libraries Source Type: news

Study identifies never-before-seen dual function in enzyme critical for cancer growth
(Larner College of Medicine at the University of Vermont) In developing therapies for hard-to-treat breast and ovarian cancers in patients with BRCA gene mutations, scientists aim to identify ways to keep cancer cells from using DNA break repair pathways. New findings demonstrate a previously-unknown capability for polymerase theta (pol theta) - a key enzyme in this repair function - that shows promise as a new avenue for treatment development. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2021 Category: Cancer & Oncology Source Type: news

How women make choices about surgery to prevent ovarian cancer
(Queen Mary University of London) A study by researchers at Queen Mary University in London has investigated how women who are at high risk of ovarian cancer make choices about possible preventive surgery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 10, 2021 Category: Cancer & Oncology Source Type: news

New study discovers possible early detection method for elusive ovarian cancer
(University of Minnesota Medical School) A study led by researchers at the University of Minnesota Medical School found a way to detect the presence of ovarian cancer in patients using Pap test samples, normally used to detect cervical cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 9, 2021 Category: Cancer & Oncology Source Type: news

Oral Contraceptives May Reduce Cancer Risk
Oral Contraceptives May Reduce Ovarian and Endometrial Cancer Risk (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - February 5, 2021 Category: General Medicine Source Type: news

Oral Contraceptives Reduce Ovarian and Endometrial Cancer Risk Oral Contraceptives Reduce Ovarian and Endometrial Cancer Risk
Oral contraceptive use is associated with a decreased risk of ovarian and endometrial cancer 3 decades after discontinuation, according to an analysis of data from more than 250,000 women.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - February 5, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

Oral Contraceptives Reduces Ovarian and Endometrial Cancer Risk Oral Contraceptives Reduces Ovarian and Endometrial Cancer Risk
Oral contraceptive use is associated with a decreased risk of ovarian and endometrial cancer 3 decades after discontinuation, according to an analysis of data from more than 250,000 women.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - February 4, 2021 Category: Internal Medicine Tags: Hematology-Oncology News Source Type: news

DECIDER to improve diagnostics and treatment of ovarian cancer with the help of AI
(University of Helsinki) The goal of the 5-year research project is to discover novel diagnostic tools and effective drug combinations based on data from high-grade serous ovarian cancer patients. Partners in this international and multidisciplinary project come from 14 organisations in seven EU countries. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 4, 2021 Category: International Medicine & Public Health Source Type: news

Popular breast cancer drugs don't work the way we thought they did
(University of Colorado at Boulder) New research suggests that a class of drugs called PARP inhibitors, designed to treat hereditary forms of ovarian and breast cancer, don't work the way we thought they did. It also paints a fuller picture of how they work, opening the door to improvements in next-generation drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 3, 2021 Category: Cancer & Oncology Source Type: news

Moffitt researchers discover mechanism that regulates anti-tumor activity of immune cells
(H. Lee Moffitt Cancer Center& Research Institute) In a new article published in Nature, Moffitt Cancer Center researchers demonstrate why some ovarian cancer patients evolve better than others and suggest possible approaches to improve patient outcomes. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 3, 2021 Category: Cancer & Oncology Source Type: news

Janssen to Highlight Robust Solid Tumor Portfolio and Pipeline at 2021 ASCO GU
February 2, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today it will highlight the depth of its solid tumor portfolio at the American Society of Clinical Oncology Genitourinary (ASCO GU) Cancers Symposium with 12 data presentations, including three company-sponsored oral presentations from the ERLEADA® (apalutamide) clinical development program. The virtual meeting will take place February 11-13, 2021. “We are committed to the development of innovative therapies for patients with genitourinary cancers for whom there remains a high unmet need,” said C...
Source: Johnson and Johnson - February 2, 2021 Category: Pharmaceuticals Tags: Our Company Source Type: news

Doctors kept assuring Emily her bloating was IBS - but then she was diagnosed with cancer
Even now, two years after she was diagnosed with ovarian cancer at the age of 23, Emily Plane cannot remember any early symptoms that marked her out from her friends. (Source: the Mail online | Health)
Source: the Mail online | Health - February 1, 2021 Category: Consumer Health News Source Type: news

Oncotarget: The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer
The objective of this Oncotarget study was to elucidate the molecular mechanism of actions of 2MeOE2, a known microtubule disrupting agent, in inducing apoptosis in ovarian tumors (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2021 Category: International Medicine & Public Health Source Type: news

Oncotarget: Simvastatin is a potential candidate drug in ovarian clear cell carcinomas
(Impact Journals LLC) " Simvastatin efficiently controlled OCCC proliferation and migration, thus showing potential as a candidate drug for the treatment of OCCC. " (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 1, 2021 Category: International Medicine & Public Health Source Type: news

Laparoscopy cost effective in untreated advanced ovarian cancer
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news

High levels of cost-sharing during PARP inhibitor treatment for ovarian cancer in the US
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - February 1, 2021 Category: Drugs & Pharmacology Source Type: news

Cholesterol starvation kills lymphoma cells
(Northwestern University) Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 25, 2021 Category: Cancer & Oncology Source Type: news

An innate response to ovarian cancer
(Source: ScienceNOW)
Source: ScienceNOW - January 21, 2021 Category: Science Authors: Malo, C. S. Tags: twis Source Type: news

Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer
Women who receive ovarian stimulation for assisted reproductive technology (ART) procedures don't have an increased risk of developing ovarian cancer, according to a new study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 19, 2021 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer Nulliparity, Not ART, Likely Raises Risk of Ovarian Cancer
Women who receive ovarian stimulation for assisted reproductive technology (ART) procedures don't have an increased risk of developing ovarian cancer, according to a new study.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 19, 2021 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

'Breakthrough' drug that halts ovarian cancer gives a supermarket worker, 56, new life
Val Simcock, 56, ran out of options in 2017 when a second bout of chemotherapy failed to halt the growth of her tumour. But the daily pill quickly stopped the cancer in its tracks. (Source: the Mail online | Health)
Source: the Mail online | Health - January 16, 2021 Category: Consumer Health News Source Type: news