First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding

Conclusion: 18F-SynVesT-2 has fast kinetics, high specific uptake, and low nonspecific uptake in the brain. Consistent with the nonhuman primate results, the kinetics of 18F-SynVesT-2 is faster than the kinetics of 11C-UCB-J and 18F-SynVesT-1 in the human brain and enables a shorter dynamic scan to derive physiologic information on cerebral blood flow and synapse density.

Source: Journal of Nuclear Medicine - March 1, 2024 Category: Nuclear Medicine Authors: Drake, L. R., Wu, Y., Naganawa, M., Asch, R., Zheng, C., Najafzadeh, S., Pracitto, R., Lindemann, M., Li, S., Ropchan, J., Labaree, D., Emery, P. R., Dias, M., Henry, S., Nabulsi, N., Matuskey, D., Hillmer, A. T., Gallezot, J.-D., Carson, R. E., Cai, Z., Tags: Clinical Investigations Source Type: research