Inefficient neural system stabilization: a theory of spontaneous resolutions and recurrent relapses in psychosis
Authors: Palaniyappan L Abstract A striking feature of psychosis is its heterogeneity. Presentations of psychosis vary from transient symptoms with no functional consequence in the general population to a tenacious illness at the other extreme, with a wide range of variable trajectories in between. Even among patients with schizophrenia, who are diagnosed on the basis of persistent deterioration, marked variation is seen in response to treatment, frequency of relapses and degree of eventual recovery. Existing theoretical accounts of psychosis focus almost exclusively on how symptoms are initially formed, with much ...
Source: Journal of Psychiatry and Neuroscience - June 29, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Cannabis involvement and neuropsychological performance: findings from the Human Connectome Project
Authors: Petker T, Owens MM, Amlung MT, Oshri A, Sweet LH, MacKillop J Abstract Background: There is evidence that heavy cannabis use is associated with decrements in cognitive performance, but findings are mixed and studies are often limited by small sample sizes and narrow adjustment for potential confounding variables. In a comparatively large sample, the current study examined associations between multiple indicators of cannabis use in relation to performance on a variety of neuropsychological tasks. Methods: Participants were 1121 adults (54% female) enrolled in the Human Connectome Project. Cannabis invol...
Source: Journal of Psychiatry and Neuroscience - June 29, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The microbiome and mental health: Hope or hype?
Authors: Taylor VH PMID: 31245969 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 29, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Management of sexual adverse effects induced by atypical antipsychotic medication
Authors: Downing L, Kim DD, Procyshyn RM`, Tibbo P PMID: 31245972 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 29, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Magnetic resonance imaging texture predicts progression to dementia due to Alzheimer disease earlier than hippocampal volume
Conclusion: Textures of the hippocampus, precuneus and posterior cingulate cortex predicted conversion from MCI to Alzheimer disease at an earlier time point and with higher accuracy than hippocampal volume. PMID: 31228173 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 24, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Dorsolateral prefrontal γ-aminobutyric acid in patients with treatment-resistant depression after transcranial magnetic stimulation measured with magnetic resonance spectroscopy
Conclusion: Treatment using rTMS was associated with increases in GABA levels at the stimulation site in the left DLPFC, and the degree of GABA change was related to clinical improvement. Participants receiving concomitant treatment with a GABA agonist were less likely to respond to rTMS. These findings were consistent with earlier studies showing the effects of rTMS on GABA levels and support a GABAergic model of depression. PMID: 31199104 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 15, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

5-HT1A receptor, 5-HT2A receptor and serotonin transporter binding in the human auditory cortex in depression
Conclusion: Depression may be associated with altered serotonergic function in the auditory cortex involving the 5-HT2A receptor and is part of a wider view of the pathophysiology of mood disorders extending beyond psychopathology. PMID: 31120232 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 25, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Truncating variant burden in high-functioning autism and pleiotropic effects of LRP1 across psychiatric phenotypes
Conclusion: Previous studies and ours suggest an effect of truncating mutations restricted to severe autism-spectrum disorder phenotypes that are associated with intellectual disability. We provide evidence for pleiotropic effects of common and rare variants in the LRP1 gene across psychiatric phenotypes. PMID: 31094488 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 18, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Time heals all wounds? A 2-year longitudinal diffusion tensor imaging study in major depressive disorder
Conclusion: This study reports follow-up diffusion tensor imaging data in patients with major depressive disorder after an acute depressive episode. We demonstrated impaired prefrontal white matter microstructure (higher mean diffusivity) at baseline in patients with major depressive disorder, which normalized at follow-up after 2 years, irrespective of disease course. This might have been due to a general treatment effect and might have reflected recovery of white matter integrity. PMID: 31094489 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 18, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Adult neuroplasticity: A new “cure” for major depression?
Adult neuroplasticity: A new “cure” for major depression? J Psychiatry Neurosci. 2019 Mar 01;44(3):147-150 Authors: Albert PR PMID: 31038297 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 2, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Canadian College of Neuropsychopharmacology 2019 award winners
Authors: PMID: 31038299 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 2, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

N-Acetylcysteine augmentation in refractory obsessive –compulsive disorder
N-Acetylcysteine augmentation in refractory obsessive–compulsive disorder J Psychiatry Neurosci. 2019 May 01;44(3):215-216 Authors: Bhaskara S PMID: 31038300 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 2, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Adult patients with ADHD differ from healthy controls in implicit, but not explicit, emotion regulation
Conclusion: Although emotion dysregulation is regarded as a core symptom of ADHD, explicit reappraisal does not seem to be impaired in adult patients. However, increased activation of the ACC implies stronger implicit emotion regulation induced by negative stimuli. This might be explained by emotional hyperresponsivity in patients with ADHD compared with controls. PMID: 31025560 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 28, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion –symptom mapping study
Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study J Psychiatry Neurosci. 2019 Apr 25;44(3):1-10 Authors: Leeuwis AE, Weaver NA, Biesbroek JM, Exalto LG, Kuijf HJ, Hooghiemstra AM, Prins ND, Scheltens P, Barkhof F, van der Flier WM, Biessels GJ, TRACE-VCI study group Abstract Background: We investigated the association between white matter hyperintensity location and depressive symptoms in a memoryclinic population using lesion–symptom mapping. Methods: We included 680 patients with vascular brain injury from t...
Source: Journal of Psychiatry and Neuroscience - April 26, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Altered thalamo –cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa: a systematic review of diffusion tensor imaging studies
Conclusion: White matter microstructure appears to be affected in anorexia nervosa, and these alterations may play a role in the pathophysiology of this eating disorder. Although we found white matter alterations in bulimia nervosa that were similar to those in anorexia nervosa, white matter changes in bulimia nervosa remain poorly investigated, and these findings were less conclusive. Further studies with longitudinal designs and multi-approach analyses are needed to better understand the role of white matter changes in eating disorders. PMID: 30994310 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 19, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Nonacceptance of negative emotions in women with borderline personality disorder: association with neuroactivity of the dorsal striatum
Conclusion: Data indicate that striatal hyperactivation during the processing of negative stimuli in women with BPD is related to their decreased disposition to accept unpleasant emotional states. Thus, individuals with BPD may benefit from therapy approaches that focus on emotion acceptance in order to normalize emotional reactions. PMID: 30964611 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 11, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Resting-state connectivity of the bed nucleus of the stria terminalis and the central nucleus of the amygdala in clinical anxiety
Conclusion: This study provides functional MRI proxies of the functional dissociation of the bed nucleus of the stria terminalis and central nucleus of the amygdala, and suggests that resting-state functional connectivity of key structures in the processing of defensive responses do not recapitulate changes related to induced state anxiety. Future work needs to replicate and further probe the clinical significance of these findings. PMID: 30964612 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 11, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Altered white matter connectivity in young people exposed to childhood abuse: a tract-based spatial statistics (TBSS) and tractography study
Conclusion: Childhood abuse is associated with altered structure of neural pathways connecting the frontal, temporal and occipital cortices that are known to mediate affect and cognitive control. The abuse-specific deficits in the ILF and IFoF suggest that fibre tracts presumably involved in conveying and processing the adverse abusive experience are specifically compromised in this population. PMID: 30964614 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 11, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Altered reward-related effective connectivity in obsessive-compulsive disorder: an fMRI study
Conclusion: This disrupted connectivity in parts of the default mode network and the frontostriatal network may indicate increased rumination and self-related processing impairing the responsiveness toward external rewards. This, in turn, may underlie the general urge for reinforcement accompanying compulsive behaviours. PMID: 30964615 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 11, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neural response to emotional faces in monozygotic twins: association with familial risk of affective disorders
Conclusion: Greater recruitment of the medial and superior prefrontal cortex during implicit emotion processing in high-risk versus affected twins may represent a compensatory or resilience mechanism. In contrast, aberrant neural response to emotional faces does not seem to be a risk endophenotype for affective disorders. PMID: 30942564 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 5, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Randomized controlled trial of a gluten-free diet in patients with schizophrenia positive for antigliadin antibodies (AGA IgG): a pilot feasibility study
Conclusion: This feasibility study suggests that removal of gluten from the diet is associated with improvement in psychiatric and gastrointestinal symptoms in people with schizophrenia or schizoaffective disorder. PMID: 30938127 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 3, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols
Authors: MacQueen GM, Hassel S, Arnott SR, Jean A, Bowie CR, Bray SL, Davis AD, Downar J, Foster JA, Frey BN, Goldstein BI, Hall GB, Harkness KL, Harris J, Lam RW, Lebel C, Milev R, Müller DJ, Parikh SV, Rizvi S, Rotzinger S, Sharma GB, Soares CN, Turecki G, Vila-Rodriguez F, Yu J, Zamyadi M, Strother SC, Kennedy SH, CAN-BIND Investigator Team Abstract Studies of clinical populations that combine MRI data generated at multiple sites are increasingly common. The Canadian Biomarker Integration Network in Depression (CAN-BIND; www.canbind.ca) is a national depression research program that includes multimodal neur...
Source: Journal of Psychiatry and Neuroscience - March 7, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Cannabis: A potential efficacious intervention for PTSD or simply snake oil?
Authors: Abizaid A, Merali Z, Anisman H PMID: 30810022 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 28, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
Conclusion: The extent of the commonalities we observed further support the concept of core neurobiological disruptions shared among the 3 disorders; ALFF signal balance could be an important neuroimaging marker for the diagnosis and treatment of schizophrenia, bipolar disorder and major depressive disorder. PMID: 30810024 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 28, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Treating resistant depression with 2 forms of convulsive therapy: a clinical case study
Authors: Daskalakis AA, Daskalakis ZJ PMID: 30810025 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 28, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm –compulsive disorder
Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm–compulsive disorder J Psychiatry Neurosci. 2019 Feb 26;44(3):1-13 Authors: Albert PR, Le François B, Vahid-Ansari F Abstract Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the ...
Source: Journal of Psychiatry and Neuroscience - February 27, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Changes of motor cortical excitability and response inhibition in patients with obsessive –compulsive disorder
Conclusion: These findings suggest abnormal cortical excitability in patients with OCD. The associations between cortical silent period and response inhibition and age of onset further indicate that altered cortical excitability may play an important role in the development of OCD. PMID: 30758161 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 14, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Unilateral and bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression: a meta-analysis of randomized controlled trials over 2 decades
Conclusion: This study suggests that rTMS has moderate antidepressant effects and appears to be promising in the short-term treatment of patients with unipolar TRD. PMID: 30720259 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 7, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

An artificial neural network model for clinical score prediction in Alzheimer disease using structural neuroimaging measures
Conclusion: The APANN provides a highly robust and scalable framework for predicting clinical severity at the individual level using high-dimensional, multimodal neuroimaging data. PMID: 30720260 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 7, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Adolescent depression and brain development: evidence from voxel-based morphometry
Conclusion: During adolescence, restructuring of the brain is characterized by marked decreases in prefrontal grey-matter volumes, interpreted as a correlate of brain maturation. Findings of greater volumes in the prefrontal cortex, particularly in younger adolescents with depression, may suggest that these participants were more prone to delayed brain maturation or increased neuroplasticity. This finding may represent a risk factor for depression or constitute an effect of developing depression. PMID: 30720261 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 7, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa: results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women
This study explored state-related tendencies in DNA methylation in people with anorexia nervosa. Methods: We measured genome-wide DNA methylation in 75 women with active anorexia nervosa (active), 31 women showing stable remission of anorexia nervosa (remitted) and 41 women with no eating disorder (NED). We also obtained post-intervention methylation data from 52 of the women from the active group. Results: Comparisons between members of the active and NED groups showed 58 differentially methylated sites (Q
Source: Journal of Psychiatry and Neuroscience - January 31, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Reduced parietofrontal effective connectivity during a working-memory task in people with high delusional ideation
Conclusion: These findings suggest that alterations in the working-memory network are also present in a nonclinical population with psychotic experiences who do not display cognitive deficits. They also suggest that alterations in working-memory-dependent connectivity show a putative continuity along the spectrum of psychotic symptoms. PMID: 30657658 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - January 20, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Spontaneous low-frequency fluctuations in the neural system for emotional perception in major psychiatric disorders: amplitude similarities and differences across frequency bands
Conclusion: We found subtle disturbances in body-ownership experiences in patients with schizophrenia, which were associated with delusions. We found no evidence for impairments in children/adolescents at increased familial risk of developing schizophrenia or a mood disorder. Longitudinal data might reveal whether impairments in body ownership are predictive of psychosis onset. PMID: 30525317 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - January 5, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Age-related deficits in intracortical myelination in young adults with bipolar disorder type I
In this study, we investigated whole-brain intracortical myelin (ICM) content in people with bipolar disorder type I and controls. Methods: Between Sept. 1, 2014, and Jan. 31, 2017, we used a 3 T General Electric scanner to collect T1-weighted images in 45 people with bipolar disorder type I and 60 controls aged 17 to 45 years using an optimized sequence that was sensitive to ICM content. We analyzed images using a surfacebased approach. We used general linear models with quadratic age terms to examine the signal trajectory of ICM across the age range. Results: In healthy controls, the T1-weighted signal followed a...
Source: Journal of Psychiatry and Neuroscience - January 5, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

From the neo-Kraepelinian framework to the new mechanical philosophy of psychiatry: regaining common sense
Authors: Joober R, Tabbane K PMID: 30565447 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

A review of functional neurological symptom disorder etiology and the integrated etiological summary model
Authors: Fobian AD, Elliott L Abstract Functional neurological symptom disorder (FNSD) is characterized by neurological symptoms that are unexplained by other traditional neurological or medical conditions. Both physicians and patients have limited understanding of FNSD, which is often explained as a physical manifestation of psychological distress. Recently, diagnostic criteria have shifted from requiring a preceding stressor to relying on positive symptoms. Given this shift, we have provided a review of the etiology of FNSD. Predisposing factors include trauma or psychiatric symptoms, somatic symptoms, illness ex...
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

ER β agonist alters RNA splicing factor expression and has a longer window of antidepressant effectiveness than estradiol after long-term ovariectomy
Conclusion: These findings suggest that ERβ alternative splicing and altered responses in the regulatory system for serotonin may mediate the antidepressant efficacy of ET associated with the timing of therapy initiation. It is likely that ERβ-specific ligands would be effective estrogen-based antidepressants late after the onset of menopause. PMID: 30565903 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Psychoradiologic abnormalities of white matter in patients with bipolar disorder: diffusion tensor imaging studies using tract-based spatial statistics
Conclusion: Our study consistently identified decreased FA in the genu and body of the corpus callosum, suggesting that interhemispheric communication may be the connectivity most affected in patients with bipolar disorder. PMID: 30565904 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Lifetime major depression and grey-matter volume
Conclusion: Major depressive disorder was associated with persistent volume reductions in the deep nuclei and insula and with enlargements in visual cortex subregions; alterations varied according to age of onset and genotype. PMID: 30565905 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Apathy alters emotional arousal in chronic schizophrenia
Conclusion: Taken together, these results suggest that apathy in schizophrenia could impair tonic activity during positive emotions. Treatments aimed at enhancing positive emotions may help alleviate apathy in schizophrenia. PMID: 30565906 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Head motion: the dirty little secret of neuroimaging in psychiatry
Authors: Makowski C, Lepage M, Evans AC Abstract Psychiatry is at a crossroads when choosing final samples for analysis of neuroimaging data. Many patient populations exhibit significantly increased motion in the scanner compared with healthy controls, suggesting that more patients would need to be excluded to obtain a clean sample. However, this need is often overshadowed by the extensive amount of time and effort required to recruit these valuable and uncommon samples. This commentary sheds light on the impact of motion on imaging studies, drawing examples from psychiatric patient samples to better understand how...
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Clozapine-induced obsessive –compulsive symptoms: mechanisms and treatment
Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatment J Psychiatry Neurosci. 2019 Jan 01;44(1):71-72 Authors: Kim DD, Barr AM, White RF, Honer WG, Procyshyn RM PMID: 30565908 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 21, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood
Conclusion: Our results suggest that threat generalization mechanisms may moderate the link between childhood maltreatment and subclinical psychopathology during emerging adulthood. Threat generalization could represent a vulnerability factor for developing later psychopathology in individuals being exposed to childhood maltreatment. PMID: 30540154 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 13, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Lateral orbitofrontal dysfunction in the Sapap3 knockout mouse model of obsessive –compulsive disorder
Conclusion: We provide, to our knowledge, the first direct in vivo electrophysiological evidence of detailed functional alterations in different neuronal types in the lateral OFC of an OCD mouse model. These findings may help in understanding the underlying neuropathophysiology and circuitry mechanisms for phenotypes relevant to OCD, and may help generate and refine hypotheses about potential biomarkers for further investigation. PMID: 30403026 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 9, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Performance monitoring and post-error adjustments in adults with attention-deficit/hyperactivity disorder: an EEG analysis
Conclusion: Based on previous reports of post-error behavioural alterations in childhood samples, we conclude that people with ADHD develop compensatory strategies across the lifespan that lead to inconspicuous post-error behaviour in adulthood. Neurophysiologically, however, subtle alterations remain, indicating a perseverance of at least some frontal lobe deficits in people with ADHD who are partially medicated, particularly with respect to action-monitoring and post-error adaptation. PMID: 30375834 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study
Conclusion: The results of the present study demonstrate changes during pharmacotherapy in the manifestation of affect, interpersonal behaviour and interpersonal perception in the daily lives of people with social anxiety disorder. Given the importance of interpersonal processes to social anxiety disorder, these results may guide future research seeking to clarify mechanisms of action for serotonergic medications. PMID: 30375835 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Psychoradiological patterns of small-world properties and a systematic review of connectome studies of patients with 6 major psychiatric disorders
Conclusion: Four psychoradiological patterns of altered small-world properties are proposed. The analysis of altered smallworld properties may provide novel insights into the pathophysiological mechanisms underlying psychiatric disorders from a connectomic perspective. In future connectome studies, the global network measures of both segregation and integration should be calculated to fully evaluate altered small-world properties in patients with a particular disease. PMID: 30375837 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Peter M. Milner, 1919 –2018
Peter M. Milner, 1919–2018 J Psychiatry Neurosci. 2018 Nov 01;43(6):428-429 Authors: White NMW PMID: 30375838 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Tic-related obsessive –compulsive disorder
Tic-related obsessive–compulsive disorder J Psychiatry Neurosci. 2018 Nov 01;43(6):431-432 Authors: Pringsheim TP, Piacentini JP PMID: 30375839 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 1, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The perils of being too stable: mood regulation in bipolar disorder
Authors: Ortiz A, Alda M PMID: 30371048 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2018 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research