Adapting to the impact of COVID-19 on mental health: an international perspective.
Authors: Thomas RK, Suleman R, Mackay M, Hayer L, Singh M, Correll CU, Dursun S PMID: 32584526 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Clozapine and COVID-19.
Authors: Remington G, Powell V PMID: 32584527 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Clozapine and COVID-19: The authors respond.
Authors: Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, Verdoux H, Wheeler A, Freudenreich O PMID: 32584530 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Long-acting injectable antipsychotics: choosing the right dose.
Authors: Carlone D, Delva N PMID: 32584531 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.
Conclusion: Together, these results suggest that changes in mGlu5 availability are not part of the earliest neural adaptations in stimulant-induced behavioural sensitization, but low mGlu5 binding might identify a higher propensity for sensitization. PMID: 32559027 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 21, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Effectiveness and safety of neuroablation for severe and treatment-resistant obsessive-compulsive disorder: a systematic review and meta-analysis.
Conclusion: Ablative surgeries are safe and effective for a large proportion of patients with severe and treatment-resistant OCD. Among the available procedures, capsulotomy seemed to be the most effective. Further research is needed to improve clinical effectiveness and minimize risks. PMID: 32549057 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - June 19, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment.
Conclusion: These data support the concept that Yif1B plays a critical role in 5-HT1AR functioning and brain 5-HT homeostasis. The opposite changes in its expression observed in anxious or depressive states and after therapeutic fluoxetine treatment suggest that Yif1B might be involved in vulnerability to anxiety and depression, and fluoxetine efficacy. PMID: 32459080 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Association between functional and structural connectivity of the corticostriatal network in people with schizophrenia and unaffected first-degree relatives.
Conclusion: Our findings provide insight into the role of hypoconnectivity of the ventral corticostriatal system in people with schizophrenia. PMID: 32436671 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 22, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Seeing the bigger picture: multimodal neuroimaging to investigate neuropsychiatric illnesses.
Authors: Plitman E, Raihaan P, Chakravarty MM PMID: 32338856 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

In memoriam: Glenda MacQueen (1965-2020).
Authors: Bray SL, Taylor VH, Arnold P PMID: 32338857 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Canadian College of Neuropsychopharmacology 2020 award winners.
Authors: PMID: 32338858 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Transcranial magnetic stimulation over the right temporoparietal junction influences the sense of agency in healthy humans.
Conclusion: Our experiments showed that the network subserving the sense of agency was amenable to neuromodulation in healthy participants. This sets the ground for further research in patients with impaired sense of agency. Clinical trial identification: DRKS00012992 (German clinical trials registry). PMID: 32329986 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 25, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Consensus statement on the use of clozapine during the COVID-19 pandemic.
Authors: Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, Verdoux H, Wheeler A, Freudenreich O PMID: 32297722 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 18, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Trauma, treatment and Tetris: video gaming increases hippocampal volume in male patients with combat-related posttraumatic stress disorder.
Conclusion: Tetris may be useful as an adjunct therapeutic intervention for PTSD. Tetris-related increases in hippocampal volume may ensure that therapeutic gains are maintained after completion of therapy. PMID: 32293830 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 17, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Predicting response to psychiatric surgery: a systematic review of neuroimaging findings.
Conclusion: Although few studies have analyzed preoperative imaging for predictors of response to psychiatric surgery, we found consistency among the reported results: most studies implicated overactivity in the frontostriatal limbic network as being correlated with clinical response. Larger prospective studies are needed. Registration: www.crd.york.ac.uk/prospero/display_record.php?RecordID=131151. PMID: 32293838 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 17, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Sex-specific pathways among tri-allelic serotonin transporter polymorphism, trait neuroticism and generalized anxiety disorder.
Conclusion: These findings are the first to show that the triallelic 5-HTTLPR polymorphism is associated with elevated risk of GAD, and that this effect is mediated via increased trait neuroticism, a sex-dependent risk pathway. PMID: 32293839 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 17, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Anatomic alterations across amygdala subnuclei in medication-free patients with obsessive-compulsive disorder.
Authors: Zhang L, Hu X, Lu L, Li B, Hu X, Bu X, Li H, Tang S, Gao Y, Yang Y, Sweeney JA, Gong Q, Huang X Abstract Background: The amygdala has been implicated in obsessive-compulsive disorder (OCD), a common, disabling illness. However, the regional distribution of anatomic alterations in this structure and their association with the symptoms of OCD remains to be established. Methods: We collected high-resolution 3D T1-weighted images from 81 untreated patients with OCD and no lifetime history of comorbid psychotic, affective or anxiety disorders, and from 95 age- and sex-matched healthy controls. We extracted ...
Source: Journal of Psychiatry and Neuroscience - April 17, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Consensus statement on the use of clozapine during the COVID-19 pandemic
Authors: Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, Verdoux H, Wheeler A, Freudenreich O PMID: 32242646 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - April 5, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Frontoparietal and salience network alterations in obsessive –compulsive disorder: insights from independent component and sliding time window analyses
Conclusion: Disrupted modulation of these intrinsic brain networks may contribute to the pathophysiology of OCD. PMID: 32167267 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 15, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The orbitofrontal cortex, food intake and obesity
Authors: Seabrook LT, Borgland SL Abstract Obesity is a major health challenge facing many people throughout the world. Increased consumption of palatable, high-caloric foods is one of the major drivers of obesity. Both orexigenic and anorexic states have been thoroughly reviewed elsewhere; here, we focus on the cognitive control of feeding in the context of obesity, and how the orbitofrontal cortex (OFC) is implicated, based on data from preclinical and clinical research. The OFC is important in decision-making and has been heavily researched in neuropsychiatric illnesses such as addiction and obsessive–comp...
Source: Journal of Psychiatry and Neuroscience - March 15, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

High-frequency versus theta burst transcranial magnetic stimulation for the treatment of poststroke cognitive impairment in humans
Authors: Tsai PY, Lin WS, Tsai KT, Kuo CY, Lin PH Abstract Background: Because the reliability of repetitive transcranial magnetic stimulation (rTMS) in treating poststroke cognitive impairment has not been convincingly demonstrated, we systematically examined the effectiveness of this regimen with 2 protocols. Methods: We randomly allocated 41 patients with poststroke cognitive impairment to receive 5 Hz rTMS (n = 11), intermittent theta burst stimulation (iTBS; n = 15) or sham stimulation (n = 15). Each group received 10 stimulation sessions over the left dorsolateral prefrontal cortex. We performed the Repea...
Source: Journal of Psychiatry and Neuroscience - March 12, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Metabolic state and value-based decision-making in acute and recovered female patients with anorexia nervosa
Conclusion: The propensity for risk aversion as found in recovered patients with anorexia nervosa could help them successfully complete therapy, or it could reflect sequelae of the disorder. Conversely, ghrelin findings might be related to a mechanism contributing to disease maintenance; that is, in acutely underweight anorexia nervosa, a hungry state may facilitate the ability to forgo an immediate reward to achieve a (dysfunctional) long-term goal. PMID: 32129584 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - March 6, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Deficits of entropy modulation of the EEG: A biomarker for altered function in schizophrenia and bipolar disorder?
Conclusion: Spectral entropy modulation with task performance is decreased in patients with schizophrenia and bipolar disorder. This deficit was not an effect of psychopharmacological treatment or structural connectivity and might reflect a deficit in the synchronization of the neural assemblies that underlie cognitive activity. PMID: 32100521 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 28, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Are mental disorders orphan diseases?
Authors: Garel N, Joober R PMID: 32096614 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Melatonin suppression by melanopsin-weighted light in patients with bipolar I disorder compared to healthy controls
Conclusion: Despite using a large cohort and highly controlled laboratory conditions, we found no differences in melatonin suppression between euthymic patients with bipolar I disorder and healthy controls. These findings do not support the notion that supersensitivity is a valid endophenotype in bipolar I disorder. PMID: 32096617 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

In memoriam: Chawki Benkelfat (1953 –2020)
In memoriam: Chawki Benkelfat (1953–2020) J Psychiatry Neurosci. 2020 Mar 01;45(2):142 Authors: Leyton M PMID: 32096618 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Mu-opioid antagonism in the treatment of cannabis use disorder
Authors: Kebir O, Laqueille X, Mouaffak F PMID: 32096619 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 27, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Hippocampal and parahippocampal volumes vary by sex and traumatic life events in children
Conclusion: Results revealed that psychological trauma affects brain development differently in girls and boys. These findings need to be followed longitudinally to elucidate how structural differences progress and contribute to well-known sex disparities in psychopathology. PMID: 32078279 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - February 22, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Indirect frontocingulate structural connectivity predicts clinical response to accelerated rTMS in major depressive disorder
Authors: Klooster DC, Vos IN, Caeyenberghs K, Leemans A, David S, Besseling RM, Aldenkamp AP, Baeken C Abstract Background: Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), but its clinical efficacy remains rather modest. One reason for this could be that the propagation of rTMS effects via structural connections from the stimulated area to deeper brain structures (such as the cingulate cortices) is suboptimal. Methods: We investigated whether structural connectivity — derived from diffusion MRI data — could serve as a biomarker to ...
Source: Journal of Psychiatry and Neuroscience - January 29, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Magnetic seizure therapy is efficacious and well tolerated for treatment-resistant bipolar depression: an open-label clinical trial
Conclusion: In treatment-resistant bipolar depression, magnetic seizure therapy produced significant improvements in depression symptoms with minimal effects on cognitive performance. These promising results warrant further investigation with larger randomized clinical trials comparing magnetic seizure therapy to electroconvulsive therapy. Clinical trial registration: NCT01596608; clinicaltrials.gov PMID: 31922372 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - January 12, 2020 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

We need an operational framework for heterogeneity in psychiatric research
Authors: Nunes A, Trappenberg T, Alda M PMID: 31845771 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 19, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Kleptomania treated with naltrexone in a patient with intellectual disability
Authors: Mouaffak F, Hamzaoui S, Kebir O, Laqueille X PMID: 31845772 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 19, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa
Conclusion: This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. PMID: 31823595 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 13, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

CACNA1C polymorphism and brain cortical structure in bipolar disorder
Conclusion: The CACNA1C polymorphism rs1006737 is associated with the mean thickness of cortical brain areas that have been shown to be altered in bipolar disorder. PMID: 31829002 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 13, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa
Conclusion: This study sheds light on the neurobiological process of how epigenetic variation in the SLC6A4 gene may relate to rsFC in the salience network that is linked to psychopathology in anorexia nervosa. PMID: 31804778 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - December 6, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial
This study investigated whether pretreatment left hippocampal volume, interhemisphere hippocampal asymmetry or both influenced EPO treatment response with respect to verbal learning. Methods: Data were available for 76 of 83 patients with mood disorders from our previous EPO trials (EPO = 37 patients; placebo = 39 patients). We performed cortical reconstruction and volumetric segmentation using FreeSurfer. We conducted multiple linear regression and logistic regression to assess the influence of left hippocampal volume and hippocampal asymmetry on EPO-related memory improvement, as reflected by change in Rey Auditory V...
Source: Journal of Psychiatry and Neuroscience - December 6, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Quantitative tractography reveals changes in the corticospinal tract in drug-na ïve children with attention-deficit/hyperactivity disorder
Conclusion: We demonstrated specific changes in the right corticospinal tract in children with ADHD. Correlations with measures of attention and response inhibition underscored the functional importance of corticospinal tract disturbance in ADHD. PMID: 31765114 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 26, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neural bases of the clinical and neurocognitive differences between earlyand late-onset obsessive –compulsive disorder
Conclusion: We provided the neural bases for clinical and neurocognitive differences to demonstrate that biological evidence underlies the distinctions between early- and late-onset OCD. This study suggests that different treatment options should be considered for the OCD subtypes, because their neurobiology differs and is related to distinct phenotypic profiles. PMID: 31765115 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 26, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic review
Conclusion: This study identified the important mediators of autonomic dysfunction and sudden death in patients with RTT. We proposed brainstem mechanisms and emphasized risk factors that increase brainstem vulnerability. We discussed clinical management to reduce sudden death and future directions for this vulnerable population. PMID: 31702122 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 10, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Psychotic symptoms are associated with lower cortical folding in youth at risk for mental illness
Conclusion: Psychotic symptoms in youth are associated with cortical folding deficits, even in the absence of psychotic illness. The current study helps clarify the neurodevelopmental basis of psychosis at an early stage, before medication, drug use and other confounds have had a persistent effect on the brain. PMID: 31674733 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - November 3, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

The 42nd Annual Meeting of the Canadian College of Neuropsychopharmacology
Authors: Larosa A, Nath M, Srivastava LK PMID: 31657536 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Treatment of first-episode psychosis in patients with autism-spectrum disorder and intellectual deficiency
Authors: Garel N, Joober R PMID: 31657537 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Sex: a key consideration in understanding the etiology of psychiatric disorders and improving treatment
Authors: Tannenbaum C, Boksa P PMID: 31657538 [PubMed - in process] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 30, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Brain structural correlates of alexithymia in patients with major depressive disorder
Conclusion: Our results showed the fusiform gyrus as a correlate of alexithymia. We also found differences related to alexithymia between patients with MDD and healthy controls in the fusiform gyrus. Our study encourages research related to the transition from risk to MDD in people with alexithymia. PMID: 31603638 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 13, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Genetic and environmental influences on corticostriatal circuits in twins with autism
Conclusion: Genetic factors primarily contribute to structural variation in subcortical CSC regions, regardless of ASD, but environmental factors may exert a greater influence on the development of grey matter thickness in the OFC and ACC in children with ASD. The increased vulnerability of OFC grey matter to environmental influences may also mediate some heterogeneity in RRB severity in children with ASD. PMID: 31603639 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 13, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Intact value-based decision-making during intertemporal choice in women with remitted anorexia nervosa? An fMRI study
Conclusion: Although our results underlined previous demonstrations of divergent temporal reward discounting in acutely underweight patients with anorexia nervosa, we found no evidence of alteration in patients with weight-recovered anorexia nervosa. Together, these findings suggest that impaired valuebased decision-making may not constitute a defining trait variable or “scar” of the disorder. PMID: 31595737 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 10, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Abnormalities of intrinsic regional brain activity in first-episode and chronic schizophrenia: a meta-analysis of resting-state functional MRI
Conclusion: Our comprehensive meta-analysis suggests that findings of aberrant regional intrinsic brain activity during the initial stages of schizophrenia, and much more widespread damage with the progression of disease, may contribute to our understanding of the progressive pathophysiology of schizophrenia. PMID: 31580042 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - October 4, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Ketamine for chronic depression: two cautionary tales
Authors: Talbot J, Phillips JL, Blier P Abstract A growing body of literature has shown the effectiveness of ketamine for treating chronic depression. How long the beneficial effects of repeated ketamine last once infusions are stopped, however, remains largely unknown. Understanding the challenges that ensue after ketamine cessation can help clinicians optimally guide patients who opt for ketamine treatment and minimize the associated risks. In this commentary, we discuss some unexpected data gathered from participants of a pilot study on the effects of adjunctive ketamine infusion for resistant depression. PM...
Source: Journal of Psychiatry and Neuroscience - October 3, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Neuroanatomical predictors of response to subcallosal cingulate deep brain stimulation for treatment-resistant depression
Conclusion: There are structural brain differences between patients with treatment-resistant depression who respond to SCG DBS and those who do not. Specifically, the structural integrity of the subcallosal cingulate gyrus target region and its connected subcortical areas, and variations in cortical volume across the entire brain, appear to be important determinants of response. Structural MRI shows promise as a biomarker in deep brain stimulation for depression, and may play a role in refining patient selection for future trials. PMID: 31525860 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 20, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research

Altered response to risky decisions and reward in patients with obsessive –compulsive disorder
Conclusion: Obsessive–compulsive disorder is associated with abnormal brain activity patterns during risky decision-making in a set of brain regions that have been consistently implicated in the processing of reward prediction errors. Alterations in affective “hot” processes implicated in decision-making may contribute to increased indecisiveness and intolerance to uncertainty in patients with OCD. PMID: 31509362 [PubMed - as supplied by publisher] (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - September 13, 2019 Category: Psychiatry Tags: J Psychiatry Neurosci Source Type: research