Colorectal carcinoma peritoneal metastases-derived organoids: results and perspective of a model for tailoring hyperthermic intraperitoneal chemotherapy from bench-to-bedside
Peritoneal metastases from colorectal cancer (CRCPM) are related to poor prognosis. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been reported to improve survival, but... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - May 2, 2024 Category: Cancer & Oncology Authors: Luca Varinelli, Davide Battistessa, Marcello Guaglio, Susanna Zanutto, Oscar Illescas, Ewelina J. Lorenc, Federica Pisati, Shigeki Kusamura, Laura Cattaneo, Giovanna Sabella, Massimo Milione, Alessia Perbellini, Sara Noci, Cinzia Paolino, Elisabetta Khun, Tags: Research Source Type: research
Correction: High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 2, 2024 Category: Molecular Biology Authors: Geriolda Topi, Shakti Ranjan Satapathy, Souvik Ghatak, Karin Hellman, Fredrik Ek, Roger Olsson, Roy Ehrnstr öm, Marie-Louise Lydrup and Anita Sjölander Tags: Correction Source Type: research
Cholesterol and Immune Microenvironment: Path Towards Tumorigenesis
AbstractPurpose of ReviewSince obesity is a major risk factor for many different types of cancer, examining one of the most closely associated comorbidities, such as hypercholesterolemia, is crucial to understanding how obesity causes cancer. Hypercholesterolemia is usually associated with many cardiovascular complications such as hypertension, angina, and atherosclerosis. In addition, cholesterol may be a major factor in increasing cancer risk. Cancer patients who received statins, an anti-hypercholesteremic medicine, demonstrated improved prognosis possibly through its effect on tumor proliferation, apoptosis, and oxidat...
Source: Current Nutrition Reports - May 2, 2024 Category: Nutrition Source Type: research
The transcriptional landscape of coding and non-coding RNAs in recurrent and non-recurrent colon cancer
A considerable number of colon cancer patients with local or local advanced disease suffer from recurrence and there is an urgent need for better prognostic biomarkers in this setting. Here, the transcriptomic landscape of messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), small nuclear RNAs (snRNAs), small nucleolar RNAs (snoRNAs), small Cajal body-specific RNAs (scaRNAs), pseudogenes and circular RNAs (circRNAs), as well as RNAs denoted as miscellaneous RNAs, was profiled by total RNA sequencing. (Source: American Journal of Pathology)
Source: American Journal of Pathology - May 2, 2024 Category: Pathology Authors: Ulrik Korsgaard, Juan L. Garc ía-Rodríguez, Theresa Jakobsen, Ulvi Ahmadov, Kim-Gwendolyn Dietrich, Stine Mary Vissing, Thea Petersen Paasch, Jan Lindebjerg, Jørgen Kjems, Henrik Hager, Lasse Sommer Kristensen Tags: Regular Article Source Type: research
An isolated vaginal metastasis from rectal cancer: a case report
ConclusionVaginal metastases from colorectal cancer are extremely rare. A vigilant gynecological examination is recommended during the follow-up of colorectal cancer patients. Diagnosis can be challenging, especially if the metastatic lesion is small and asymptomatic, even after standard radiological examination. Surgical resection followed by chemotherapy is a valid option for patients with early isolated metastases. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 2, 2024 Category: General Medicine Source Type: research
Molecules, Vol. 29, Pages 2110: Metabolic Rewiring in Cancer: Small Molecule Inhibitors in Colorectal Cancer Therapy
Regina
Alterations in cellular metabolism, such as dysregulation in glycolysis, lipid metabolism, and glutaminolysis in response to hypoxic and low-nutrient conditions within the tumor microenvironment, are well-recognized hallmarks of cancer. Therefore, understanding the interplay between aerobic glycolysis, lipid metabolism, and glutaminolysis is crucial for developing effective metabolism-based therapies for cancer, particularly in the context of colorectal cancer (CRC). In this regard, the present review explores the complex field of metabolic reprogramming in tumorigenesis and progression, providing insights into...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Domiziana Masci Michela Puxeddu Romano Silvestri Giuseppe La Regina Tags: Review Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | PMC:PMC11068426 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Effect of Orem's self-care model on discharge readiness of patients undergoing enterostomy: A randomized controlled trial
CONCLUSIONS: The designed discharge readiness program based on Orem's self-care could promote effective patient discharge readiness, self-care knowledge, self-care skills, and QoL.TRIAL REGISTRATION: The trial number ChiCTR2200056302 registered on ClinicalTrials.gov.PMID:38692158 | DOI:10.1016/j.ejon.2024.102549 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 1, 2024 Category: Nursing Authors: Si-Qing Li Cui-Lian Luo Hong Qiu Yu-Xia Liu Jian-Min Chen Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: J Psychiatry Neurosc...)
Source: J Psychiatry Neurosc... - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Disproportionate neuroanatomical effects of < em > DCC < /em > haploinsufficiency in adolescence compared with adulthood: links to dopamine, connectivity, covariance, and gene expression brain maps in mice
CONCLUSION: The neuroanatomical phenotype of DCC haploinsufficiency described in mice parallels that observed in DCC-haploinsufficient humans. It is critical to understand the DCC-haploinsufficient mouse as a clinically relevant model system.PMID:38692693 | DOI:10.1503/jpn.230106 (Source: Journal of Psychiatry and Neuroscience)
Source: Journal of Psychiatry and Neuroscience - May 1, 2024 Category: Psychiatry Authors: Daniel Hoops Yohan Yee Christopher Hammill Sammi Wong Colleen Manitt Barry J Bedell Lindsay Cahill Jason P Lerch Cecilia Flores John G Sled Source Type: research
Effect of Orem's self-care model on discharge readiness of patients undergoing enterostomy: A randomized controlled trial
CONCLUSIONS: The designed discharge readiness program based on Orem's self-care could promote effective patient discharge readiness, self-care knowledge, self-care skills, and QoL.TRIAL REGISTRATION: The trial number ChiCTR2200056302 registered on ClinicalTrials.gov.PMID:38692158 | DOI:10.1016/j.ejon.2024.102549 (Source: European Journal of Oncology Nursing)
Source: European Journal of Oncology Nursing - May 1, 2024 Category: Nursing Authors: Si-Qing Li Cui-Lian Luo Hong Qiu Yu-Xia Liu Jian-Min Chen Source Type: research
Zinc Suppresses Colorectal Cancer Development through Cell-mediated Immunity
Yakugaku Zasshi. 2024;144(5):475-481. doi: 10.1248/yakushi.23-00154-1.ABSTRACTZinc is one of the essential trace elements, and is involved in various functions in the body. Zinc deficiency is known to cause immune abnormalities, but the mechanism is not fully understood. Therefore, we focused our research on tumor immunity to elucidate the effect of zinc on colorectal cancer and its mechanisms. Mice were treated with azoxymethane (AOM) and dextran sodium sulfate (DSS) to develop colorectal cancer, then the relationship between zinc content in the diet and the number and area of tumors in the colon was observed. The number ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 1, 2024 Category: Drugs & Pharmacology Authors: Keigo Nishida Naoya Nakagawa Source Type: research
Molecular targets and mechanisms of different aberrant alternative splicing in metastatic liver cancer
World J Clin Oncol. 2024 Apr 24;15(4):531-539. doi: 10.5306/wjco.v15.i4.531.ABSTRACTMetastasis remains a major challenge in the successful management of malignant diseases. The liver is a major site of metastatic disease and a leading cause of death from gastrointestinal malignancies such as colon, stomach, and pancreatic cancers, as well as melanoma, breast cancer, and sarcoma. As an important factor that influences the development of metastatic liver cancer, alternative splicing drives the diversity of RNA transcripts and protein subtypes, which may provide potential to broaden the target space. In particular, the dysfun...
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: De-Yi Geng Qing-Shan Chen Wan-Xian Chen Lin-Sa Zhou Xiao-Sha Han Qi-Hu Xie Geng-Hong Guo Xue-Fen Chen Jia-Sheng Chen Xiao-Ping Zhong Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
