Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation
Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bo... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 15, 2020 Category: Molecular Biology Authors: Aihua Xu, Yang Yang, Yang Shao, Meng Wu and Yongxin Sun Tags: Research Source Type: research

Apoptotic mimicry as a strategy for the establishment of parasitic infections: parasite- and host-derived phosphatidylserine as key molecule
The establishment of parasitic infection is dependent on the development of efficient strategies to evade the host defense mechanisms. Phosphatidylserine (PS) molecules are pivotal for apoptotic cell recogniti... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 15, 2020 Category: Molecular Biology Authors: Jo ão Luiz Mendes Wanderley, Renato Augusto DaMatta and Marcello André Barcinski Tags: Review Source Type: research

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy
NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 14, 2020 Category: Molecular Biology Authors: Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter and Gottfried Baier Tags: Research Source Type: research

SapC-DOPS – a Phosphatidylserine-targeted Nanovesicle for selective Cancer therapy
Phosphatidylserine (PS) is normally located in the inner leaflet of the membrane bilayer of healthy cells, however it is expressed at high levels on the surface of cancer cells. This has allowed for the develo... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 9, 2020 Category: Molecular Biology Authors: Kombo F. N ’Guessan, Priyankaben H. Patel and Xiaoyang Qi Tags: Review Source Type: research

FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer
Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 9, 2020 Category: Molecular Biology Authors: Weixing Dai, Xianke Meng, Shaobo Mo, Wenqiang Xiang, Ye Xu, Long Zhang, Renjie Wang, Qingguo Li and Guoxiang Cai Tags: Research Source Type: research

Correction to: The balance of Bmp6 and Wnt10b regulates the telogen-anagen transition of hair follicles
Following publication of the original article [1], the authors reported that they would like to correct the second last sentence of “Authors’ information” section as PW is an undergraduate, but was incorrectly... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 7, 2020 Category: Molecular Biology Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li Tags: Correction Source Type: research

Comprehensive profiling identifies a novel signature with robust predictive value and reveals the potential drug resistance mechanism in glioma
Gliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance i... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 6, 2020 Category: Molecular Biology Authors: Fan Zeng, Kuanyu Wang, Xiu Liu and Zheng Zhao Tags: Research Source Type: research

Ras isoforms: signaling specificities in CD40 pathway
Ras are small cellular GTPases which regulate diverse cellular processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1 –165 residues) sequence homology these isoforms were thought ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 6, 2020 Category: Molecular Biology Authors: Arathi Nair, Sushmita Chakraborty, Late Anirban Banerji, Ankita Srivastava, Charudutta Navare and Bhaskar Saha Tags: Research Source Type: research

RNA sequencing reveals an additional Crz1-binding motif in promoters of its target genes in the human fungal pathogen Candida albicans
The calcium/calcineurin signaling pathway is mediated by the transcription factors NFAT (nuclear factor of activated T cells) in mammals and Crz1 (calcineurin-responsive zinc finger 1) in yeasts and other lowe... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 3, 2020 Category: Molecular Biology Authors: Huihui Xu, Tianshu Fang, Raha Parvizi Omran, Malcolm Whiteway and Linghuo Jiang Tags: Research Source Type: research

The let-7 family of microRNAs suppresses immune evasion in head and neck squamous cell carcinoma by promoting PD-L1 degradation
Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signa... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 27, 2019 Category: Molecular Biology Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu and Lianji Wen Tags: Research Source Type: research

Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37
LRP5/6 are co-receptors in Wnt/ β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 27, 2019 Category: Molecular Biology Authors: Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang and Dan-ni Ren Tags: Research Source Type: research

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling
Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the de... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 26, 2019 Category: Molecular Biology Authors: Magdalena Banach-Or łowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb and Marta Miączyńska Tags: Research Source Type: research

Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metast... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 26, 2019 Category: Molecular Biology Authors: Sandra Grund-Gr öschke, Georg Stockmaier and Fritz Aberger Tags: Review Source Type: research

Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs
Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 23, 2019 Category: Molecular Biology Authors: Kate řina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal and Vítězslav Bry Tags: Research Source Type: research

Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment
Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlyin... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 17, 2019 Category: Molecular Biology Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida and Kyoko Hida Tags: Research Source Type: research

N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis
In vitro chondrogenesis depends on the concerted action of numerous signalling pathways, many of which are sensitive to the changes of intracellular Ca2+ concentration. N-methyl-D-aspartate (NMDA) glutamate recep... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 16, 2019 Category: Molecular Biology Authors: Csaba Matta, Tam ás Juhász, János Fodor, Tibor Hajdú, Éva Katona, Csilla Szűcs-Somogyi, Roland Takács, Judit Vágó, Tamás Oláh, Ádám Bartók, Zoltan Varga, Gyorgy Panyi, László Csernoch and Róza Zákány Tags: Research Source Type: research

Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 16, 2019 Category: Molecular Biology Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia and Dan J. Raz Tags: Research Source Type: research

NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma
Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, th... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 16, 2019 Category: Molecular Biology Authors: Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang and Juan Chen Tags: Research Source Type: research

Bystander effects of ionizing radiation: conditioned media from X-ray irradiated MCF-7 cells increases the angiogenic ability of endothelial cells
Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy. Radiotherapy also affects non-tumoral cells present in the tumor mic... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 16, 2019 Category: Molecular Biology Authors: Nasrollah Jabbari, Muhammad Nawaz and Jafar Rezaie Tags: Research Source Type: research

Expression of E-cadherin and specific CXCR3 isoforms impact each other in prostate cancer
Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progres... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 12, 2019 Category: Molecular Biology Authors: Bo Ma, Ahmad Khazali, Hanshuang Shao, Yuhan Jiang and Alan Wells Tags: Research Source Type: research

TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination
Interleukin-22 (IL-22) belongs to the IL-10 cytokine family and is mainly produced by activated Th1 cells. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression c... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 10, 2019 Category: Molecular Biology Authors: Wei Li, Fen Li, Weiwei Lei and Zezhang Tao Tags: Research Source Type: research

1,25-(OH)2D3/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27
Recent evidence has suggested that the 1,25(OH)2D3/Vitamin D receptor (VDR) acts to suppress the immune response associated with systemic lupus erythematosus (SLE), a serious multisystem autoimmune disease. Hence... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 10, 2019 Category: Molecular Biology Authors: Dan Liu, Yu-Xuan Fang, Xia Wu, Wei Tan, Wei Zhou, Yu Zhang, Yan-Qing Liu and Guo-Qing Li Tags: Research Source Type: research

Dimerization of MORC2 through its C-terminal coiled-coil domain enhances chromatin dynamics and promotes DNA repair
Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finge... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 3, 2019 Category: Molecular Biology Authors: Hong-Yan Xie, Tai-Mei Zhang, Shu-Yuan Hu, Zhi-Ming Shao and Da-Qiang Li Tags: Research Source Type: research

Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions
Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicob... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 3, 2019 Category: Molecular Biology Authors: Urszula Zarzecka, Aileen Harrer, Anna Zawilak-Pawlik, Joanna Skorko-Glonek and Steffen Backert Tags: Research Source Type: research

Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer
Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of kar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 29, 2019 Category: Molecular Biology Authors: Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn and Stephan Singer Tags: Research Source Type: research

Correction to: MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin
Following publication of the original article [1], the authors reported that Figs. 3 and 6 are incorrect. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 28, 2019 Category: Molecular Biology Authors: Jinsoo Song, Dongkyun Kim, Churl-Hong Chun and Eun-Jung Jin Tags: Correction Source Type: research

TAM receptors, Phosphatidylserine, inflammation, and Cancer
The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK – compr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 27, 2019 Category: Molecular Biology Authors: Tal Burstyn-Cohen and Avi Maimon Tags: Review Source Type: research

The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective
Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway pl... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 27, 2019 Category: Molecular Biology Authors: Yan Xu, Shumei Song, Zhenning Wang and Jaffer A. Ajani Tags: Review Source Type: research

S100P is a molecular determinant of E-cadherin function in gastric cancer
In this study, we aimed to identify molecular interactors that influence the expression and func... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 25, 2019 Category: Molecular Biology Authors: Patr ícia Carneiro, Ana Margarida Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira, Maria Sofia Fernandes, Anabela Ferro, Raquel Almeida, Carla Oliveira, Fátima Carneiro, Fernando Schmitt, Joana Paredes, Sérgia Velho and Raquel Seruca Tags: Research Source Type: research

Distinct functions of AKT isoforms in breast cancer: a comprehensive review
AKT, also known as protein kinase B, is a key element of the PI3K/AKT signaling pathway. Moreover, AKT regulates the hallmarks of cancer, e.g. tumor growth, survival and invasiveness of tumor cells. After AKT ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 21, 2019 Category: Molecular Biology Authors: Nico Hinz and Manfred J ücker Tags: Review Source Type: research

ΗΙF1α, EGR1 and SP1 co-regulate the erythropoietin receptor expression under hypoxia: an essential role in the growth of non-small cell lung cancer cells
Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent EPO inducer, is a major stimulating factor in the g... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 21, 2019 Category: Molecular Biology Authors: Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum and Qiuyang Zhang Tags: Research Source Type: research

SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability
Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its functi... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 21, 2019 Category: Molecular Biology Authors: Nanyang Yang, Sitong Liu, Tian Qin, Xintong Liu, Nobumoto Watanabe, Kevin H. Mayo, Jiang Li and Xiaomeng Li Tags: Research Source Type: research

Correction to: Inhibition of the key metabolic pathways, glycolysis and lipogenesis, of oral cancer by bitter melon extract
Following publication of the original article [1], it was reported that Fig. 1c was not entirely readable due to overlapping Fig. 1d. The publishers apologise for this error. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 19, 2019 Category: Molecular Biology Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray Tags: Correction Source Type: research

TPP-related mitochondrial targeting copper (II) complex induces p53-dependent apoptosis in hepatoma cells through ROS-mediated activation of Drp1
In this study, a novel mitochondrion-targeting copper (... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 19, 2019 Category: Molecular Biology Authors: Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng and Xiaoyong Wang Tags: Research Source Type: research

Targeting bone morphogenetic protein receptor 2 sensitizes lung cancer cells to TRAIL by increasing cytosolic Smac/DIABLO and the downregulation of X-linked inhibitor of apoptosis protein
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 19, 2019 Category: Molecular Biology Authors: Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J. Augeri, Youyi Peng, Salma K. Jabbour and John Langenfeld Tags: Research Source Type: research

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion
Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 15, 2019 Category: Molecular Biology Authors: Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi and P äivi J. Koskinen Tags: Research Source Type: research

Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk
Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we teste... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 14, 2019 Category: Molecular Biology Authors: Masoumeh Es-Haghi, Kasun Godakumara, Annika H äling, Freddy Lättekivi, Arina Lavrits, Janeli Viil, Aneta Andronowska, Tamer Nafee, Victoria James, Ülle Jaakma, Andres Salumets and Alireza Fazeli Tags: Research Source Type: research

The regulatory roles of neutrophils in adaptive immunity
Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of ne... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 14, 2019 Category: Molecular Biology Authors: Yang Li, Wei Wang, Fan Yang, Yanan Xu, Chang Feng and Yong Zhao Tags: Review Source Type: research

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis
Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 12, 2019 Category: Molecular Biology Authors: Weilong Hong, Ge Zhang, Hong Lu, Yangyang Guo, Shizhang Zheng, Hengyue Zhu, Yanyi Xiao, Akuetteh Percy David Papa, Cunzao Wu, Linxiao Sun, Bicheng Chen and Yongheng Bai Tags: Research Source Type: research

Extracellular vesicle cross-talk between pulmonary artery smooth muscle cells and endothelium during excessive TGF- β signalling: implications for PAH vascular remodelling
Excessive TGF- β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and signific... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 8, 2019 Category: Molecular Biology Authors: Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby and Andrew H. Baker Tags: Research Source Type: research

ATM controls DNA repair and mitochondria transfer between neighboring cells
Intercellular communication is essential for multicellular tissue vitality and homeostasis. We show that healthy cells message protective signals through direct cell –cell connections to adjacent DNA–damaged ce... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 8, 2019 Category: Molecular Biology Authors: Sha Jin and Nils Cordes Tags: Short report Source Type: research

Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway
Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breas... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 7, 2019 Category: Molecular Biology Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi Tags: Research Source Type: research

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients
In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 6, 2019 Category: Molecular Biology Authors: Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bj ørkøy, Peter ten Dijke and Toril Holien Tags: Research Source Type: research

Loss-of-function phenotype of a PKC θT219A knockin mouse strain
Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 6, 2019 Category: Molecular Biology Authors: Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Sch örgenhuber, Sarah Danklmaier, Michael Leitges and Gottfried Baier Tags: Research Source Type: research

Correction to: Transcriptional activation of CBF β by CDK11p110 is necessary to promote osteosarcoma cell proliferation
Following publication of the original article [1], it was reported that Figs. 4 and 5 were not updated during the production process. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 29, 2019 Category: Molecular Biology Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan Tags: Correction Source Type: research

Flipping the dogma – phosphatidylserine in non-apoptotic cell death
The exposure of phosphatidylserine (PS) on the outer plasma membrane has long been considered a unique feature of apoptotic cells. Together with other “eat me” signals, it enables the recognition and phagocyto... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 29, 2019 Category: Molecular Biology Authors: Inbar Shlomovitz, Mary Speir and Motti Gerlic Tags: Review Source Type: research

Targeting PKC ι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma
p21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKC ι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the pres... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 28, 2019 Category: Molecular Biology Authors: Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, David Llig é, Imane Chaib, Xiaoyan Sun, Jing Miao, Rongwei Sun, Xueting Cai, Alberto Verlicchi, Morihito Okada, Miguel Angel Molina-Vila, Niki Karachaliou, Peng Cao and Rafael Rosell Tags: Research Source Type: research

The PPAR- γ antagonist T007 inhibits RANKL-induced osteoclastogenesis and counteracts OVX-induced bone loss in mice
Osteoclasts are key determinant cellular components implicated in the development and progression of disorders driven by bone damage. Herein, we studied the upshot of T007, an antagonist of peroxisome prolifer... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 26, 2019 Category: Molecular Biology Authors: Xiang Li, Lei Ning, Jianjun Ma, Ziang Xie, Xiangde Zhao, Gangliang Wang, Xinyu Wan, Pengcheng Qiu, Teng Yao, Haoming Wang, Shunwu Fan and Shuanglin Wan Tags: Research Source Type: research

The multi-site docking protein Grb2-associated binder 1 (Gab1) enhances interleukin-6-induced MAPK-pathway activation in an SHP2-, Grb2-, and time-dependent manner
Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signa... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 24, 2019 Category: Molecular Biology Authors: Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller and Fred Schaper Tags: Research Source Type: research

Notch pathway: a bistable inducer of biological noise?
Notch signalling pathway is central to development of metazoans. The pathway codes a binary fate switch. Upon activation, downstream signals contribute to resolution of fate dichotomies such as proliferation/d... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 22, 2019 Category: Molecular Biology Authors: Filip Vujovic, Neil Hunter and Ramin M. Farahani Tags: Hypothesis Source Type: research