mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy
Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neuronal cell... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 26, 2021 Category: Molecular Biology Authors: Sanjar Batirovich Madrakhimov, Jin Young Yang, Jin Ha Kim, Jung Woo Han and Tae Kwann Park Tags: Research Source Type: research

Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity
Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique chara... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 26, 2021 Category: Molecular Biology Authors: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell and Edouard I. Azzam Tags: Research Source Type: research

Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysio... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2021 Category: Molecular Biology Authors: Zhu Liang, Andreas Damianou, Elena Di Daniel and Benedikt M. Kessler Tags: Review Source Type: research

Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis
The oncogenic transcript factor c-Maf is stabilized by the deubiquitinase Otub1 and promotes myeloma cell proliferation and confers to chemoresistance. Inhibition of the Otub1/c-Maf axis is a promising therape... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2021 Category: Molecular Biology Authors: Tong Sun, Yujia Xu, Zhuan Xu, Biyin Cao, Zubin Zhang, Qi Wang, Yan Kong and Xinliang Mao Tags: Research Source Type: research

Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid
Over the past years, Human Amnion Epithelial Cells (hAECs), a placental stem cell, are gaining higher attention from the scientific community as they showed several advantages over other types of stem cells, i... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2021 Category: Molecular Biology Authors: Meriem Bejaoui, Farhana Ferdousi, Yun-Wen Zheng, Tatsuya Oda and Hiroko Isoda Tags: Short report Source Type: research

Abelson kinase ’s intrinsically disordered region plays essential roles in protein function and protein stability
The non-receptor tyrosine kinase Abelson (Abl) is a key player in oncogenesis, with kinase inhibitors serving as paradigms of targeted therapy. Abl also is a critical regulator of normal development, playing c... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2021 Category: Molecular Biology Authors: Edward M. Rogers, S. Colby Allred and Mark Peifer Tags: Research Source Type: research

Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer ’s disease
Alzheimer ’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathologica... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 24, 2021 Category: Molecular Biology Authors: Smita Eknath Desale and Subashchandrabose Chinnathambi Tags: Review Source Type: research

Cancer-derived exosomal miR-7641 promotes breast cancer progression and metastasis
Intercellular communication is crucial for breast cancer progression and metastasis. However, the role of cancer-derived exosomes and their crucial microRNA (miRNA) cargoes mediating intercellular communicatio... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2021 Category: Molecular Biology Authors: Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou and Qiang Sun Tags: Research Source Type: research

FZD5 prevents epithelial-mesenchymal transition in gastric cancer
Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2021 Category: Molecular Biology Authors: Dan Dong, Lei Na, Kailing Zhou, Zhuo Wang, Yu Sun, Qianqian Zheng, Jian Gao, Chenghai Zhao and Wei Wang Tags: Research Source Type: research

L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
Metastasis is the predominant cause for cancer morbidity and mortality accounting for approximatively 90% of cancer deaths. The actin-bundling protein L-plastin has been proposed as a metastatic marker and pho... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 22, 2021 Category: Molecular Biology Authors: Raquel A. C. Machado, Dunja Stojevski, S ébastien De Landtsheer, Philippe Lucarelli, Alexandre Baron, Thomas Sauter and Elisabeth Schaffner-Reckinger Tags: Research Source Type: research

S-1-propenylcysteine improves TNF- α-induced vascular endothelial barrier dysfunction by suppressing the GEF-H1/RhoA/Rac pathway
Vascular endothelial barrier function is maintained by cell-to-cell junctional proteins and contributes to vascular homeostasis. Various risk factors such as inflammation disrupt barrier function through down-... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2021 Category: Molecular Biology Authors: Kayo Kunimura, Satomi Miki, Miyuki Takashima and Jun-ichiro Suzuki Tags: Research Source Type: research

Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression
Our previous studies have shown that the E3 ubiquitin ligase of HMG-CoA reductase degradation 1 (HRD1) functions as a tumor suppressor, as overexpression of HRD1 suppressed breast cancer proliferation and inva... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2021 Category: Molecular Biology Authors: Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin and Dongming Su Tags: Research Source Type: research

Drug resistance and Cancer stem cells
Therapy resistance is a major problem when treating cancer patients as cancer cells develop mechanisms that counteract the effect of therapeutic compounds, leading to fit and more aggressive clones that contri... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 15, 2021 Category: Molecular Biology Authors: Yuan Li, Zhenning Wang, Jaffer A. Ajani and Shumei Song Tags: Review Source Type: research

Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin
Colorectal familial adenomatous polyposis (FAP) adenomas exhibit a uniform pathogenetic basis caused by a germline mutation in the adenomatous polyposis gene (APC), but the molecular changes leading to their deve... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 12, 2021 Category: Molecular Biology Authors: Christoph Roser, Csaba T óth, Marcus Renner, Esther Herpel and Peter Schirmacher Tags: Research Source Type: research

Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
Amyloid aggregate deposition is the key feature of Alzheimer ’s disease. The proteinaceous aggregates found in the afflicted brain are the intra-neuronal neurofibrillary tangles formed by the microtubule-associ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 12, 2021 Category: Molecular Biology Authors: Shweta Kishor Sonawane, Vladimir N. Uversky and Subashchandrabose Chinnathambi Tags: Research Source Type: research

Icariside I specifically facilitates ATP or nigericin-induced NLRP3 inflammasome activation and causes idiosyncratic hepatotoxicity
Epimedii Folium (EF) is commonly used for treating bone fractures and joint diseases, but the potential hepatotoxicity of EF limits its clinical application. Our previous study confirms that EF could lead to i... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 11, 2021 Category: Molecular Biology Authors: Yuan Gao, Guang Xu, Li Ma, Wei Shi, Zhilei Wang, Xiaoyan Zhan, Nan Qin, Tingting He, Yuming Guo, Ming Niu, Jiabo Wang, Zhaofang Bai and Xiaohe Xiao Tags: Research Source Type: research

PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function
Abnormal neovascularization is the most common cause of blindness, and hypoxia alters tissue metabolism, function, and morphology. HIF-1 α, the transcriptional activator of VEGF, has intricate mechanisms of nuc... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 11, 2021 Category: Molecular Biology Authors: Lijie Dong, Wenbo Li, Tingting Lin, Boshi Liu, Yaru Hong, Xiaomin Zhang and Xiaorong Li Tags: Research Source Type: research

Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT
TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR. Blockade of TIGIT/PVR is considered as a pr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 8, 2021 Category: Molecular Biology Authors: Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao and Yanfeng Gao Tags: Research Source Type: research

Immuno-oncology: are TAM receptors in glioblastoma friends or foes?
Tyro3, Axl, and Mertk (TAM) receptors are a subfamily of receptor tyrosine kinases. TAM receptors have been implicated in mediating efferocytosis, regulation of immune cells, secretion of inflammatory factors,... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 28, 2021 Category: Molecular Biology Authors: Yunxiang Zhou, Yali Wang, Hailong Chen, Yanyan Xu, Yi Luo, Yongchuan Deng, Jianmin Zhang and Anwen Shao Tags: Review Source Type: research

Phosphatases in toll-like receptors signaling: the unfairly-forgotten
Over the past 2 decades, pattern recognition receptors (PRRs) have been shown to be on the front line of many illnesses such as autoimmune, inflammatory, and neurodegenerative diseases as well as allergies and... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 25, 2021 Category: Molecular Biology Authors: Val érie Lannoy, Anthony Côté-Biron, Claude Asselin and Nathalie Rivard Tags: Review Source Type: research

Slit/Robo signaling regulates Leydig cell steroidogenesis
First identified as a regulator of neuronal axon guidance, Slit/Robo signaling has since been implicated in additional physiologic and pathologic processes, such as angiogenesis, organogenesis and cancer progr... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 21, 2021 Category: Molecular Biology Authors: Emmanuelle Martinot and Derek Boerboom Tags: Research Source Type: research

Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer
To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 21, 2021 Category: Molecular Biology Authors: Jin Qian, Zi-chen Gong, Yi-na Zhang, Hong-hua Wu, Jing Zhao, Li-ting Wang, Li-juan Ye, Da Liu, Wei Wang, Xia Kang, Jun Sheng, Wei Xu, Xi-lin Liu, Juan Wu and Wei Zheng Tags: Research Source Type: research

On the role of bacterial metalloproteases in COVID-19 associated cytokine storm
The cytokine release syndrome or cytokine storm, which is the hyper-induction of inflammatory responses has a central role in the mortality rate of COVID-19 and some other viral infections. Interleukin-6 (IL-6... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 13, 2021 Category: Molecular Biology Authors: L ászló Földvári-Nagy, Tamás Schnabel, Gabriella Dörnyei, Tamás Korcsmáros and Katalin Lenti Tags: Hypothesis Source Type: research

Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling
Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 12, 2021 Category: Molecular Biology Authors: Shivangi Pande, Xuehui Yang and Robert Friesel Tags: Review Source Type: research

Effects of therapeutic probiotics on modulation of microRNAs
Probiotics are beneficial bacteria that exist within the human gut, and which are also present in different food products and supplements. They have been investigated for some decades, due to their potential b... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 11, 2021 Category: Molecular Biology Authors: Amirhossein Davoodvandi, Havva Marzban, Pouya Goleij, Amirhossein Sahebkar, Korosh Morshedi, Samaneh Rezaei, Maryam Mahjoubin-Tehran, Hossein Tarrahimofrad, Michael R. Hamblin and Hamed Mirzaei Tags: Review Source Type: research

PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors
Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpres... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 11, 2021 Category: Molecular Biology Authors: Alexandre Videira, Felipe C. Beckedorff, Lucas F. daSilva and Sergio Verjovski-Almeida Tags: Research Source Type: research

FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that is overexpressed or activated in several advanced-stage solid cancers. It is known to play both kinase-dependent and -independent roles in pro... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 7, 2021 Category: Molecular Biology Authors: Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou and Paris A. Skourides Tags: Research Source Type: research

Connecting the αα-hubs: same fold, disordered ligands, new functions
Signal fidelity depends on protein –protein interaction–‘hubs’ integrating cues from large interactomes. Recently, and based on a common secondary structure motif, the αα-hubs were defined, which are small α-h... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 6, 2021 Category: Molecular Biology Authors: Lasse Staby, Katrine Bugge, Rasmus Greve Falbe-Hansen, Edoardo Salladini, Karen Skriver and Birthe B. Kragelund Tags: Commentary Source Type: research

TNF α priming through its interaction with TNFR2 enhances endothelial progenitor cell immunosuppressive effect: new hope for their widespread clinical application
Bone marrow derived endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) involved in neo-angiogenesis and endothelial homeostasis and are considered as a circulating reservoir for endotheli... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 4, 2021 Category: Molecular Biology Authors: Mahsa Nouri Barkestani, Sara Shamdani, Mazdak Afshar Bakshloo, Nassim Arouche, Bijan Bambai, Georges Uzan and Sina Naserian Tags: Research Source Type: research

Calcium mediated functional interplay between myocardial cells upon laser-induced single-cell injury: an in vitro study of cardiac cell death signaling mechanisms
The electromechanical function of myocardial tissue depends on the intercellular communication between cardiomyocytes (CMs) as well as their crosstalk with other cell types. Cell injury, and subsequent death t... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 28, 2020 Category: Molecular Biology Authors: Krishna Chander Sridhar, Nils Hersch, Georg Dreissen, Rudolf Merkel and Bernd Hoffmann Tags: Research Source Type: research

Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19
The rapid ability of SARS-CoV-2 to spread among humans, along with the clinical complications of coronavirus disease 2019 —COVID-19, have represented a significant challenge to the health management systems wor... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 27, 2020 Category: Molecular Biology Authors: Gustavo A. Arga ñaraz, Julys da Fonseca Palmeira and Enrique R. Argañaraz Tags: Review Source Type: research

The G αi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane
G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins plays an important role in the cellular regulation of responses to external stimuli. Despite intensive structural research, the mechani... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - December 11, 2020 Category: Molecular Biology Authors: Agnieszka Polit, Beata Rysiewicz, Pawe ł Mystek, Ewa Błasiak and Marta Dziedzicka-Wasylewska Tags: Research Source Type: research

Pathogenic effects of inhibition of mTORC1/STAT3 axis facilitates Staphylococcus aureus-induced pyroptosis in human macrophages
Pyroptosis is a recently identified pathway of caspase-mediated cell death in response to microbes, lipopolysaccharide, or chemotherapy in certain types of cells. However, the mechanism of how pyroptosis is re... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 30, 2020 Category: Molecular Biology Authors: Ruiyuan Yao, Yuhao Chen, Huifang Hao, Zhixin Guo, Xiaoou Cheng, Yuze Ma, Qiang Ji, Xiaoru Yang, Yanfeng Wang, Xihe Li and Zhigang Wang Tags: Research Source Type: research

Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions
Macrophages adapt to microenvironments, and change metabolic status and functions to regulate inflammation and/or maintain homeostasis. In joint cavities, synovial macrophages (SM) and synovial fibroblasts (SF... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 30, 2020 Category: Molecular Biology Authors: Noritaka Saeki and Yuuki Imai Tags: Research Source Type: research

The role of mitophagy in innate immune responses triggered by mitochondrial stress
Mitochondria are important cellular organelles involved in many different functions, from energy generation and fatty acid oxidation to cell death regulation and immune responses. Accumulating evidence indicat... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 25, 2020 Category: Molecular Biology Authors: Yinjuan Song, Yang Zhou and Xiangmei Zhou Tags: Review Source Type: research

The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling
The matrix metalloproteinase-9 (MMP-9) is up-regulated by several proinflammatory mediators in the central nervous system (CNS) diseases. Increasing reports show that MMP-9 expression is an inflammatory biomar... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 23, 2020 Category: Molecular Biology Authors: Tsong-Hai Lee, Pei-Shan Liu, Ming-Ming Tsai, Jiun-Liang Chen, Su-Jane Wang and Hsi-Lung Hsieh Tags: Research Source Type: research

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56Lck regulates T-cell activation independently of Lck/CD45 interactions
Upon engagement of the T-cell receptor (TCR), the Src-family protein tyrosine kinase p56Lck phosphorylates components of the TCR (e.g. the TCR ζ chains), thereby initiating T-cell activation. The enzymatic acti... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 23, 2020 Category: Molecular Biology Authors: Matthias K ästle, Camilla Merten, Roland Hartig, Thilo Kaehne, Ardiyanto Liaunardy-Jopeace, Nadine M. Woessner, Wolfgang W. Schamel, John James, Susana Minguet, Luca Simeoni and Burkhart Schraven Tags: Research Source Type: research

Synergistic effects of EMPs and PMPs on pulmonary vascular leakage and lung injury after ischemia/reperfusion
Vascular leakage is an important pathophysiological process of critical conditions such as shock and ischemia –reperfusion (I/R)-induced lung injury. Microparticles (MPs), including endothelial cell-derived mic... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 23, 2020 Category: Molecular Biology Authors: Jie Zhang, Yu Zhu, Yue Wu, Qing-Guang Yan, Xiao-Yong Peng, Xin-Ming Xiang, Ming-Ying Xue, Qing-Hui Li, Liang-Ming Liu and Tao Li Tags: Research Source Type: research

The tail of cryptochromes: an intrinsically disordered cog within the mammalian circadian clock
Cryptochrome (CRY) proteins play an essential role in regulating mammalian circadian rhythms. CRY is composed of a structured N-terminal domain known as the photolyase homology region (PHR), which is tethered ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 16, 2020 Category: Molecular Biology Authors: Gian Carlo G. Parico and Carrie L. Partch Tags: Commentary Source Type: research

Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
The circadian circuit, a roughly 24  h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycl... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 11, 2020 Category: Molecular Biology Authors: Jacqueline F. Pelham, Jay C. Dunlap and Jennifer M. Hurley Tags: Review Source Type: research

Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors
Phase three clinical trial evidence suggests that colorectal cancers with the KRAS G13D mutation may benefit from EGFR inhibitors, like cetuximab, in contrast to the other most common KRAS mutations. A mechani... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 5, 2020 Category: Molecular Biology Authors: Thomas McFall, Noah K. Schomburg, Kent L. Rossman and Edward C. Stites Tags: Short report Source Type: research

The intrinsically disordered region of GCE protein adopts a more fixed structure by interacting with the LBD of the nuclear receptor FTZ-F1
The Drosophila melanogaster Germ cell-expressed protein (GCE) is a paralog of the juvenile hormone (JH) receptor - Methoprene tolerant protein (MET). Both proteins mediate JH function, preventing precocious diffe... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 5, 2020 Category: Molecular Biology Authors: Marta Kolonko, Dominika Bystranowska, Micha ł Taube, Maciej Kozak, Mark Bostock, Grzegorz Popowicz, Andrzej Ożyhar and Beata Greb-Markiewicz Tags: Research Source Type: research

Eukaryotic translation initiation factors as promising targets in cancer therapy
The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for gene expression, and occurs principally at the initiation phase which is mainly regulated by eukaryotic initiation ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 4, 2020 Category: Molecular Biology Authors: Peiqi Hao, Jiaojiao Yu, Richard Ward, Yin Liu, Qiao Hao, Su An and Tianrui Xu Tags: Review Source Type: research

Clathrin- and dynamin-dependent endocytosis limits canonical NF- κB signaling triggered by lymphotoxin β receptor
Lymphotoxin β receptor (LTβR) is a member of tumor necrosis factor receptor (TNFR) superfamily which regulates the immune response. At the cellular level, upon ligand binding, the receptor activates the pro-in... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 4, 2020 Category: Molecular Biology Authors: Ma łgorzata Maksymowicz, Marta Miączyńska and Magdalena Banach-Orłowska Tags: Research Source Type: research

Proteomics identifies differences in fibrotic potential of extracellular vesicles from human tendon and muscle fibroblasts
Fibroblasts are the powerhouses responsible for the production and assembly of extracellular matrix (ECM). Their activity needs to be tightly controlled especially within the musculoskeletal system, where chan... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 4, 2020 Category: Molecular Biology Authors: Ching-Yan Chlo é Yeung, Erwin M. Schoof, Michal Tamáš, Abigail L. Mackey and Michael Kjaer Tags: Research Source Type: research

The biology of tardigrade disordered proteins in extreme stress tolerance
Disordered proteins have long been known to help mediate tolerance to different abiotic stresses including freezing, osmotic stress, high temperatures, and desiccation in a diverse set of organisms. Recently, ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 4, 2020 Category: Molecular Biology Authors: Cherie Hesgrove and Thomas C. Boothby Tags: Review Source Type: research

Correction to: Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells
An amendment to this paper has been published and can be accessed via the original article. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 28, 2020 Category: Molecular Biology Authors: Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin and Lilach O. Lerman Tags: Correction Source Type: research

Mitochondrial DNA drives noncanonical inflammation activation via cGAS –STING signaling pathway in retinal microvascular endothelial cells
Pathological stimuli cause mitochondrial damage and leakage of mitochondrial DNA (mtDNA) into the cytosol, as demonstrated in many cell types. The cytosolic mtDNA then drives the activation of noninfectious in... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 28, 2020 Category: Molecular Biology Authors: Yue Guo, Ruiping Gu, Dekang Gan, Fangyuan Hu, Gang Li and Gezhi Xu Tags: Research Source Type: research

LncRNAH19 improves insulin resistance in skeletal muscle by regulating heterogeneous nuclear ribonucleoprotein A1
This study aimed to investigate the function of LncRNA H1... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 28, 2020 Category: Molecular Biology Authors: Weiwei Gui, Wei Fen Zhu, Yiyi Zhu, Shengjie Tang, Fenping Zheng, Xueyao Yin, Xihua Lin and Hong Li Tags: Research Source Type: research

The ferroptosis and iron-metabolism signature robustly predicts clinical diagnosis, prognosis and immune microenvironment for hepatocellular carcinoma
In this study, we comprehensively analyzed genes related to ferroptosis and iron metabolism to construct diagnostic and prognostic models and explore the relationship with the immune microenvironment in HCC. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 28, 2020 Category: Molecular Biology Authors: Bufu Tang, Jinyu Zhu, Jie Li, Kai Fan, Yang Gao, Shimiao Cheng, Chunli Kong, Liyun Zheng, Fazong Wu, Qiaoyou Weng, Chenying Lu and Jiansong Ji Tags: Research Source Type: research