Contribution to Pharmacy/pharmacist Education through Writing
Yakugaku Zasshi. 2024;144(3):243-247. doi: 10.1248/yakushi.23-00182.ABSTRACTThe Education Award of the Pharmaceutical Society of Japan (PSJ) was conferred for "Contribution to pharmacy/pharmacist education through writing on organic chemistry." The award-winning activities were described in three parts section 1-3. Section 1 Importance of Research and Education in Organic Chemistry: In this section, it is explained that organic chemistry serves as the fundamental basis for a wide range of natural science disciplines studied in pharmaceutical departments. It emphasizes that having a solid foundation in organic chemistry is ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hideaki Natsugari Source Type: research

Comprehensive Assessment of Cardiovascular Toxicity~From Basic to Clinic~
Yakugaku Zasshi. 2024;144(3):249-250. doi: 10.1248/yakushi.23-00164-F.NO ABSTRACTPMID:38432932 | DOI:10.1248/yakushi.23-00164-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Yasunari Kanda Junko Kurokawa Source Type: research

Evaluation of Contractile Function Using Human iPS Cell-derived Cardiomyocytes
Yakugaku Zasshi. 2024;144(3):251-255. doi: 10.1248/yakushi.23-00164-1.ABSTRACTCardiotoxicity induced by anti-cancer drugs is a significant concern for patients undergoing cancer treatment. Some anti-cancer drugs can damage cardiac muscle cells directly or indirectly, potentially leading to severe heart failure. Various risk factors, including the type and dosage of chemotherapy agents as well as patient background, contribute to the development of cardiotoxicity. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), which enable patient-specific toxicity prediction, hold great promise in this regard. Howe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Junko Kurokawa Satoshi Shimizu Kazuho Sakamoto Source Type: research

Development of Preventive Methods for Drug-induced Cardiotoxicity Using a Large-scale Medical Information Database
Yakugaku Zasshi. 2024;144(3):257-264. doi: 10.1248/yakushi.23-00164-2.ABSTRACTCancer therapies have evolved considerably thereby substantially improving the survival of patients with cancer. However, cardiotoxicity, such as myocarditis and heart failure, induced by anticancer drugs, including immune checkpoint inhibitor(ICI)s and doxorubicin, present serious challenges. Numerous observations have indicated increased risks of cardiotoxicity- and cancer-related mortality in patients with drug-induced cardiotoxicity. Therefore, the prevention and management of drug-induced cardiotoxicity should be prioritized to enable sustai...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hirofumi Hamano Yoshito Zamami Soichiro Ushio Takahiro Niimura Mitsuhiro Goda Yuki Izawa-Ishizawa Keisuke Ishizawa Source Type: research

Prediction of Cardiac Toxicity by Anti-cancer Drugs Using iPSC Cardiomyocytes
Yakugaku Zasshi. 2024;144(3):265-271. doi: 10.1248/yakushi.23-00164-3.ABSTRACTRecent advances in cancer therapy have significantly improved the survival rate of patients with cancer. In contrast, anti-cancer drug-induced adverse effects, especially cardiotoxicity, have come to affect patients' prognosis and quality of life. Therefore, there is a growing need to understand the anti-cancer drug-induced cardiotoxicity. Human induced pluripotent stem (iPS) cell-derived cardiomyocytes (hiPSC-CMs) have been used to assess drug-induced cardiotoxicity by improving the predictability of clinical cardiotoxicity and the principles of...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Shota Yanagida Yasunari Kanda Source Type: research

Life-oriented Chemistry in Pharmaceutical Sciences: Frontiers of Functional Molecule Development for Advanced Molecular Imaging
Yakugaku Zasshi. 2024;144(3):273-274. doi: 10.1248/yakushi.23-00168-F.NO ABSTRACTPMID:38432936 | DOI:10.1248/yakushi.23-00168-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Yuta Fujikawa Daisuke Asanuma Source Type: research

Imaging of In Vivo Oxygen Tension Based on Phosphorescence Lifetime Microscopy
Yakugaku Zasshi. 2024;144(3):275-283. doi: 10.1248/yakushi.23-00168-1.ABSTRACTMolecular oxygen plays essential roles in aerobic organisms as a terminal electron acceptor in the electron transport chain in mitochondria. The intracellular oxygen concentration of the entire body is strictly regulated by a balance between the supply of oxygen from blood vessels and the consumption of oxygen in mitochondria. The disruption of oxygen homeostasis in the body often results in serious pathologies such as cancer, cerebral infarction, and chronic kidney disease, and thus considerable effort has been devoted to the development of suit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Toshitada Yoshihara Source Type: research

Chemical Design of Radiohalogenated Agents Using Neopentyl Structure
Yakugaku Zasshi. 2024;144(3):285-290. doi: 10.1248/yakushi.23-00168-2.ABSTRACTMany useful radionuclides exist among the halogen elements. Fluorine-18 (18F) is used for positron emission tomography (PET) diagnosis, iodine-123 and iodine-131 (131I) for single photon emission computed tomography (SPECT) diagnosis, 131I for nuclear medicine therapy, and iodine-125 (125I) for research. Astatine-211 (211At), which can be produced by a cyclotron and is attracting attention as a versatile α-ray emitting radionuclide, also belongs to the halogen family. Therefore, if a labeling agent that can stably hold radio-halogens can be deve...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Tomoya Uehara Source Type: research

Radiotheranostics Based on Chemical Control of Radioactivity Pharmacokinetics
Yakugaku Zasshi. 2024;144(3):291-297. doi: 10.1248/yakushi.23-00168-3.ABSTRACTRecently, radiotheranostics, which systematically combines diagnosis by nuclear medicine imaging and treatment by internal radiotherapy, constitutes a new modality in cancer treatment, with some clinical reports showing marked effects on cancer. We have been developing multifunctional chelates containing a target recognition unit, a radiation release unit, and a radioactivity pharmacokinetics control unit in the same molecule to develop efficient agents for cancer radiotheranostics based on chemical control of radioactivity pharmacokinetics. Usin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Masahiro Ono Source Type: research

Modulation of Aggregation and Immunogenicity of a Protein: Based on the Study of Hen Lysozyme
This study focuses on the modulation of protein aggregation and immunogenicity. As a starting point for investigating long-range interactions within a non-native protein, the effects of perturbing denatured protein states on their aggregation, including the formation of amyloid fibrils, were evaluated. The effects of adducts, sugar modifications, and stabilization on protein aggregation were then examined. We also investigated how protein immunogenicity was affected by enhancing protein conformational stability and other factors.PMID:38432940 | DOI:10.1248/yakushi.23-00192 (Source: Yakugaku Zasshi : Journal of the Pharmace...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Tadashi Ueda Source Type: research

Forty-three Years of Dedicated Efforts in Advancing Pharmacist Expertise: Aspiring to Become a Pharmacist and Cultivate Pharmacists Proficient in Recommending Prescription Medicines to Doctors
Yakugaku Zasshi. 2024;144(3):311-328. doi: 10.1248/yakushi.23-00193.ABSTRACTWhen I graduated from university, my aim was to become a pharmacist capable of recommending prescription medicines to doctors and teaching others to do the same. To achieve this goal, I developed comprehensive curricula incorporating progressive educational tools such as problem-based learning and small group discussions. Subsequently, the effectiveness of these tools and curricula was evaluated, and the findings of these assessments were published in various peer-reviewed journal articles. Consequently, a body of evidence on the most effective way...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hitomi Teramachi Source Type: research

Validation of the Qualitative Study Findings using Quantitative Analyses on the Current Status of Pharmacists in Home Health Care in Medium-Sized Areas
Yakugaku Zasshi. 2024;144(3):329-338. doi: 10.1248/yakushi.23-00126.ABSTRACTAlthough the issue of home medical care and pharmacists remains widespread, much of the discussion has concentrated on its state in urban areas. We believe that it is necessary to consider the state of home health care in medium-sized regions, that is separate from its urban form, with a population of approximately 100000. Thus, we conducted a qualitative study in Hikone City, Shiga Prefecture, to identify factors that impede pharmacists involved in home medical care. We conducted a questionnaire-based survey in an area of the same size to verify t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Kaori Yokomaku Tomohisa Yasuhara Misa Nagata Masahiro Ueda Taro Kushihata Tomomichi Sone Source Type: research

Contribution to Pharmacy/pharmacist Education through Writing
Yakugaku Zasshi. 2024;144(3):243-247. doi: 10.1248/yakushi.23-00182.ABSTRACTThe Education Award of the Pharmaceutical Society of Japan (PSJ) was conferred for "Contribution to pharmacy/pharmacist education through writing on organic chemistry." The award-winning activities were described in three parts section 1-3. Section 1 Importance of Research and Education in Organic Chemistry: In this section, it is explained that organic chemistry serves as the fundamental basis for a wide range of natural science disciplines studied in pharmaceutical departments. It emphasizes that having a solid foundation in organic chemistry is ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hideaki Natsugari Source Type: research

Comprehensive Assessment of Cardiovascular Toxicity~From Basic to Clinic~
Yakugaku Zasshi. 2024;144(3):249-250. doi: 10.1248/yakushi.23-00164-F.NO ABSTRACTPMID:38432932 | DOI:10.1248/yakushi.23-00164-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Yasunari Kanda Junko Kurokawa Source Type: research

Evaluation of Contractile Function Using Human iPS Cell-derived Cardiomyocytes
Yakugaku Zasshi. 2024;144(3):251-255. doi: 10.1248/yakushi.23-00164-1.ABSTRACTCardiotoxicity induced by anti-cancer drugs is a significant concern for patients undergoing cancer treatment. Some anti-cancer drugs can damage cardiac muscle cells directly or indirectly, potentially leading to severe heart failure. Various risk factors, including the type and dosage of chemotherapy agents as well as patient background, contribute to the development of cardiotoxicity. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), which enable patient-specific toxicity prediction, hold great promise in this regard. Howe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Junko Kurokawa Satoshi Shimizu Kazuho Sakamoto Source Type: research