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Development of Biologically Active Compounds on the Basis of Phosphonic and Phosphinic Acid Functionalities.
Abstract  Phosphonic and phosphinic acids, especially α-heteroatom-substituted ones, possess unique structural and physical features which enable them to act as hydrotically stable analogs to biological phosphates in biological processes. They also act as mimetics in the transition state of the protease-induced hydrolysis of dipeptides. The first half of this review focuses on selected new synthetic methods developed by our research group for the stereoselective synthesis of α-heteroatom-substituted phosphonic and phosphinic acid derivatives, including modified nucleotide analogs and phosphinyl di...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Yokomatsu T Tags: Yakugaku Zasshi Source Type: research

Development of a Prodrug of Levofloxacin to Avoid Chelation with Al(3+) and of Pemetrexed Dimedoxomil Esters for Oral Administration.
Abstract  An ethoxycarbonyl 1-ethyl hemiacetal ester of levofloxacin (LVFX-EHE) avoids insoluble chelate formation with metal-containing drugs in the intestinal tract and is rapidly hydrolyzed to the parent drug. Furthermore, the minimum inhibitory concentration confirms that LVFX-EHE is less likely to cause pseudomembranous colitis because of less susceptibility to normal intestinal bacteria flora. Pemetrexed dimedoxomil, the prodrug of pemetrexed, was synthesized via reaction with medoxomil bromide after modification of L-glutamate with the tert-butyloxycarbonyl protecting group (BOC), followed by hydrolysi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Matsuyama K Tags: Yakugaku Zasshi Source Type: research

Convergent Synthesis of Fused Ring Systems in Large Polycyclic Ethers.
This article reviews our studies on the oxiranyl anion-based, [X+2+Y]-type convergent strategy for the synthesis of polycyclic ether natural products. The strategy is noteworthy for its flexibility, which allows for the generation of different-sized fused ring systems based on a ring expansion reaction. For a precise understanding of this key ring expansion, we first focused on the reaction mechanism, in which an equatorial attack of TMS-diazomethane was determined to be the crucial step. In the later part of this review, the application of our oxiranyl anion-based strategy to large fused ring systems is described. The adv...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Sakai T Tags: Yakugaku Zasshi Source Type: research

Studies of Neuronal Gene Regulation Controlling the Molecular Mechanisms Underlying Neural Plasticity.
Abstract  The regulation of the development and function of the nervous system is not preprogramed but responds to environmental stimuli to change neural development and function flexibly. This neural plasticity is a characteristic property of the nervous system. For example, strong synaptic activation evoked by environmental stimuli leads to changes in synaptic functions (known as synaptic plasticity). Long-lasting synaptic plasticity is one of the molecular mechanisms underlying long-term learning and memory. Since discovering the role of the transcription factor cAMP-response element-binding protein in lea...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Fukuchi M Tags: Yakugaku Zasshi Source Type: research

Meta-analysis on the Influence of Antifungal Spectrum on Effectiveness of Empirical Antifungal Therapy for Febrile Neutropenia.
Abstract  We conducted a meta-analysis to investigate the influence of antifungal spectrum on the effectiveness and adverse events of empirical antifungal therapy for febrile neutropenia. We searched PubMed and Cochrane Central Register of Controlled Trials (Central), and identified randomized controlled trials reporting mortality, efficacy, adverse events, and hepatic and renal dysfunction. Five trials assessed the efficacy and adverse events of agents with antifungal spectrum covering and those not covering Aspergillus. There were no differences in mortality [risk ratio (RR); 0.79, 95% confidence interval (...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Irikuchi J, Imai T, Tanaka M, Tanuma M, Orii T, Kato T Tags: Yakugaku Zasshi Source Type: research

Frequency of Acute Kidney Injury Caused by Tazobactam/Piperacillin in Patients with Pneumonia and Chronic Kidney Disease: A Retrospective Observational Study.
We examined the effect of these different dosing regimens on renal function. We studied a cohort of 57 patients with impaired renal function hospitalized with pneumonia and treated with TAZ/PIPC between January 2015 and November 2016. Patients were classified into four groups according to TAZ/PIPC dose: 2.25 g three times daily (Group A); 2.25 g four times daily (B); 4.5 g twice daily (C) and 4.5 g three times daily (D). We examined the frequency of acute kidney injury (AKI) and treatment effectiveness. In Groups A, B, C and D, AKI occurred in 5.6%, 0.0%, 25.0% and 38.5% of patient. In groups C and D, hydration and dose re...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Morimoto T, Nagashima H, Morimoto Y, Tokuyama S Tags: Yakugaku Zasshi Source Type: research

Increase of Anti-oxidative Capacity during Differentiation of 3T3-L1 Preadipocytes into Adipocytes.
Abstract  Cells have developed ingenious defense mechanisms in response to oxidative stress. Here, we evaluated changes in anti-oxidative capacity during differentiation of 3T3-L1 preadipocytes into adipocytes. When 3T3-L1 preadipocytes were treated with H2O2 (0.10-2.0 mM) for 21 h, cell viability decreased in response to H2O2 concentration, with an LD50 of approximately 0.35 mM H2O2. In the cells undergoing differentiation at 2 and 6 d, LD50 increased to 1.0 and>2.0 mM H2O2, respectively. These results indicate that resistance to oxidative stress dramatically increased with progression of differentiation ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Muraoka S, Nitta Y, Yamada T, Sakuma Y, Ichimura A, Sakurai K Tags: Yakugaku Zasshi Source Type: research

A Metabolic Study on the Biochemical Effects of Chiral Illegal Drugs in Rats Using (1)H-NMR Spectroscopy.
Abstract  Considering the pharmacological effects of chiral drugs, enantiopure drugs may differ from their racemic mixture formulation in efficacy, potency, or adverse effects. Levomethorphan (LVM) and Dextromethorphan (DXM) act on the central nervous system and exhibit different pharmacological features. LVM, the l-stereoisomer of methorphan, shows many similarities to opiates such as heroin, morphine and codeine, including the potential for addiction, while the d-stereoisomer, DXM, does not have the same opioid effect. In the present study, NMR-based metabolomics were performed on the urine of rats treated ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Fukuhara K, Ohno A, Kikura-Hanajiri R Tags: Yakugaku Zasshi Source Type: research

Relationship between Hydrogen-bond Conditions of Surface Adsorbed Water and Interparticle Binding Force on Pharmaceutical Tablets.
In this study, the hydrogen bonds states of the surface adsorbed waters on the excipient particles of the tablets were focused upon, and the relationship to the interparticle binding force determined by the Rumpf equation was discussed using a near-infrared spectroscopy (NIR). As for the results, NIR peaks of OH groups of surface water were shifted by a humidity change, and the degrees of the peak shifts correlated to interparticle binding force. PMID: 28867702 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Ito T, Kamiya H Tags: Yakugaku Zasshi Source Type: research

Patient Preference for Aggressive Medication Therapies with Potentially Stronger Adverse Drug Reactions Revealed Using a Scenario-based Survey.
Abstract  Some patients do not inform healthcare professionals of adverse drug reactions (ADRs) because they fear termination of aggressive medication therapies. Preferences for aggressive medication therapies may differ between patients and pharmacists. The goal of this study was to estimate whether pharmacists were able to accurately assess patient preference for aggressive medication therapies with potentially stronger ADRs. A cross-sectional study was conducted of hospitalized patients (35 to 74 years of age) receiving oral medications for a chronic disease or systemic chemotherapy at three hospitals in J...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Iihara N, Ohara E, Nishio T, Muguruma H, Matsuoka E, Houchi H, Kirino Y Tags: Yakugaku Zasshi Source Type: research

Evaluation of Retinal Function in Streptozotocin-induced Diabetic Rats by Using the Electroretinography and Immunohistochemistry Methods.
In conclusion, we showed that the enhanced thickening in retina was caused by the injection of excessive STZ. The thickening in retina of STZ rats may lead to the dysfunction of retina, resulting in the decrease in ERG. These findings provide significant information that can be used in the design of a model of diabetic retinopathy. PMID: 28867704 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Hiramatsu N, Deguchi S, Yoshioka C, Otake H, Yamamoto N, Nagai N Tags: Yakugaku Zasshi Source Type: research

Validating the Effectiveness of Switching the Vancomycin TDM Analysis Software Based on the Predictive Accuracy.
Abstract  Based on the predictive performance in our previous study, we switched the therapeutic drug monitoring (TDM) analysis software for dose setting of vancomycin (VCM) from "Vancomycin MEEK TDM analysis software Ver2.0" (MEEK) to "SHIONOGI-VCM-TDM ver.2009" (VCM-TDM) in January 2015. In the present study, our aim was to validate the effectiveness of the changing VCM TDM analysis software in initial dose setting of VCM. The enrolled patients were divided into two groups, each having 162 patients in total, who received VCM with the initial dose set using MEEK (MEEK group) or VCM-TDM (V...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 6, 2017 Category: Drugs & Pharmacology Authors: Imai S, Yamada T, Ishiguro N, Miyamoto T, Kagami K, Tomiyama N, Niinuma Y, Nagasaki D, Suzuki K, Yamagami A, Kasashi K, Kobayashi M, Iseki K Tags: Yakugaku Zasshi Source Type: research

Inhalation Exposure Method for Illegal Drugs.
Abstract  We developed a new inhalation exposure method to evaluate effects of synthetic cannabimimetics that are being distributed as new, unregulated drugs in the Tokyo area. We selected the commercial product "SOUTOU" containing AB-CHMINACA and 5F-AMB as the test drug and dried marshmallow (Althaea officinalis) leaves as the negative control. A half cigarette packed with dried marshmallow leaves or SOUTOU was ignited, then mainstream smoke from each was delivered to five mice in an exposure box. After the cigarettes were fully consumed, neurobehavioral observations and a catalepsy test were perfo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Inomata A, Ogata A, Tada Y, Nagasawa A, Yuzawa K, Ando H, Kubo Y, Takahashi H, Kaihoko F, Tanaka K, Nakajima J, Suzuki A, Uemura N, Moriyasu T, Watanabe D, Ishihara K, Usami T, Kamei S, Kohno Y Tags: Yakugaku Zasshi Source Type: research

A Method for Decreasing the Amount of the Drug Remaining on the Surfaces of the Mortar and Pestle after Grinding Small Amount of Tablets.
Abstract  The aim of the present study was to develop a method for grinding tablets with a mortar and pestle while reducing drug loss because grinding tablets is known to be associated with reductions in tablet weight and loss of the active drug. Seven kinds of tablets were subjected to grinding. The proportion (%) of the amount of the active drug in the powder remaining on the surfaces of the mortar and pestle relative to the total amount of the drug recovered (the recovery percent) was calculated. The recovery percent of the 7 kinds of tablets ranged from 17.2-35.9%, and the tablets' recovery percent decrea...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Kawakami M, Kitada R, Kurita T, Tokumura T Tags: Yakugaku Zasshi Source Type: research

Relationship between Hay Fever and Mineral Concentration in the Hair, Lifestyle or Aging.
In this study, we investigated the relationship between hay fever and mineral concentrations in hair to obtain findings on the risk of developing pollen allergies. A questionnaire survey was conducted for 275 men and 977 women on their lifestyle habits and ten kinds of mineral concentrations present in their hair were measured with subsequent analysis using nominal logistic regression analysis. The results indicated that half the patients in each age group had hay fever, with no significant difference between hay fever and aging, exercise habits, sleep and dietary rhythms. On the other hand, there was a significant differe...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Yamashiro K, Ogata F, Kawasaki N Tags: Yakugaku Zasshi Source Type: research

What the Desirable Collaboration between Care Workers in Nursing Homes and Phamacists Should Be: An Approach for Security and Safe Medication for Residents in Nursing Homes.
Abstract  In our previous research, there was no collaboration between care workers and pharmacists, for the most part. As a result, it was discovered that in some cases, problems concerning medication of nursing home residents had not been resolved. To solve this issue, we brought together care workers and pharmacists for a workshop we conducted. We assigned 12 care workers with at least two years of experience and 12 pharmacists to four mixed groups and guided them in the management of in-home long-term medical care and conducted small group discussions (SGD) using the KJ method. In the pre-survey before th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Maki H, Shiraishi A, Miki A, Satoh H, Konishi Y, Asai K, Funahashi K, Usui Y, Sawada Y Tags: Yakugaku Zasshi Source Type: research

Establishing a Case-study Program for the Promotion of Home Medical Care of Pharmacists-Fusing Education and Clinical Support.
PMID: 28768944 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Yoshitake T, Ohsawa T Tags: Yakugaku Zasshi Source Type: research

Background on Establishing a Working Group to Create Home Clinical Cases for Education.
Abstract  In Japan there are concerns that there will be a surge in social insurance costs such as medical and nursing care expenses as a result of the baby boom generation reaching the late stages of old age (75 years old and beyond) around 2025 ("The 2025 Problem"). In 2012, the "Outline on Social Insurance and Tax Reform" was approved by the Japanese cabinet and government, including "construction of regional comprehensive care". To promote participation in home medical care by pharmacists, this article presents the roles demanded of pharmacists in regional comprehensive care ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Yoshitake T Tags: Yakugaku Zasshi Source Type: research

Present Conditions and Problems of Home Care Education in Pharmaceutical Education: Through the Activities of "the Working Group to Create Home Clinical Cases for Education".
Present Conditions and Problems of Home Care Education in Pharmaceutical Education: Through the Activities of "the Working Group to Create Home Clinical Cases for Education". Yakugaku Zasshi. 2017;137(8):935-940 Authors: Kobuke Y Abstract  In the pharmaceutical education model core curriculums revision, "basic qualities required as a pharmacist" are clearly shown, and "the method based on learning outcomes" has been adopted. One of the 10 qualities (No. 7) is "Practical ability of the health and medical care in the community". In the large item "F. Pha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Kobuke Y Tags: Yakugaku Zasshi Source Type: research

Present Activities and Problems of Home Medical Care by Pharmacists.
Abstract  The rapidly aging population in Japan led to the revision of the dispensing fees, with reviews of the system for added fees on prescriptions for home-bound patients by one-pharmacist pharmacies. However, given the current situation, it is difficult for pharmacies to be engaged in home care, so there are few small pharmacies that are willing to do so. This situation led to a decrease in the number of pharmacists who are experienced in home care. Pharmacists are requesting that practical training in home care be included in the Model Core Curriculum. It is difficult for all students to receive Sample ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Koga S, Nishimura T Tags: Yakugaku Zasshi Source Type: research

Roles and Educational Effects of Clinical Case Studies in Home Medical Care.
Abstract  Due to the progression of aging in Japan, pharmacists need to participate in home medical care. To enable pharmacists with no previous experience to participate in home medical care of patients with various diseases in the home environment, it is necessary to adopt an approach of training them in advance. It is thought useful for such clinical training to include patient case studies, which may facilitate the training of pharmacists for home medical care through simulated experience. "The working group to create home clinical cases for education" was launched by a group of university facul...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Ohsawa T, Shimazoe T Tags: Yakugaku Zasshi Source Type: research

Design and Synthesis of Peroxisome Proliferator-activated Receptor (PPAR) Gamma Antagonists Based on the Principle of Operation of Nuclear Receptor I.
Abstract  Peroxisome proliferator-activated receptor γ (PPARγ) antagonist is a molecular target to create drug for the treatment of not only type 2 diabetes and obesity, but also cancer. However, few rational drug design strategies and concepts are available. Here, we utilized the nuclear receptor helix12-folding inhibition hypothesis, in combination with structural biology data of our PPARγ agonist (5) complexed with the PPARγ ligand-binding domain. We found a potent phenylalkynyl amide-type PPARγ antagonist 18i, based on pinpoint structural modification of the acidic head part ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Ohashi M, Miyachi H Tags: Yakugaku Zasshi Source Type: research

Investigation of Oral Preparation That Is Expected to Improve Medication Administration: Preparation and Evaluation of Oral Gelling Tablet Using Sodium Alginate.
Abstract  We investigated the preparation of a gelling tablet that swells and forms a gel upon absorbing water, and hence would be easy for patients to swallow. We prepared naked tablets and compressed coated tablets by the direct tableting or wet granule-compression methods, using the commonly prescribed drug acetaminophen (AA) and sodium alginate (AG) as a thickening agent. The tablets quickly absorbed water, had favorable gelling properties, low adhesiveness, appropriate drug dissolution profile, and at the same time, were easy to swallow. In the case of naked tablets, water absorption increased upon granu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Ito I, Ito A, Unezaki S Tags: Yakugaku Zasshi Source Type: research

Characterization and Evaluation of Skin Permeation of Tocopheryl Phosphoric Acid-loaded Phospholipid Nanoparticles.
Abstract  Tocopheryl phosphoric acid (TPA, a hydrophilic vitamin E derivative) loaded liposome and glycerin containing phospholipid nanoparticles (GPLNP) were prepared using the film rehydration and extrusion method. Nanoparticle formulations were evaluated for size, zeta potential, and in vitro permeation across hairless mouse skin, and (31)P NMR spectral analysis was performed. The prepared formulations were stable for 2 weeks, and their mean nanoparticle size varied between 90 and 140 nm. Although glycerin did not affect the particle size of the empty (no TPA) system, TPA-loading resulted in the reduction ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Uchino T, Miyazaki Y, Fujii A, Kagawa Y Tags: Yakugaku Zasshi Source Type: research

Evaluation of an Evidence-based Medicine Educational Program for Pharmacists and Pharmacy Students.
This study evaluated the effect of an evidence-based medicine (EBM) educational program on EBM-related knowledge and skills of pharmacists and pharmacy students. Our preliminary educational program included the following four sessions: 1) ice breaker, 2) formulation of answerable clinical questions from virtual clinical scenario using the PICO criteria, 3) critical appraisal of the literature using a checklist, and 4) critical appraisal of the results and integrating the evidence with experience and patients values. Change in knowledge and skills related to EBM were evaluated using pre- and post-seminar 4-point scale quest...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Shimizu T, Ueda M, Toyoyama M, Ohmori S, Takagaki N Tags: Yakugaku Zasshi Source Type: research

Effects of Tramadol Coadministration on Prothrombin Time-International Normalized Ratio in Patients Receiving Warfarin.
Abstract  Several case studies have reported a possible drug interaction between warfarin and tramadol where tramadol coadministration enhanced the antithrombotic effects of warfarin. To assess this drug interaction, changes in prothrombin time-international normalized ratio (PT-INR) before and after tramadol coadministration were investigated in patients receiving warfarin. For this study, we examined 54 patients (male/female: 22/32, 68.4±12.7 years) who were being treated with warfarin for deep vein thrombosis, atrial fibrillation, arteriosclerosis obliterans, congestive heart failure, and other vasc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 6, 2017 Category: Drugs & Pharmacology Authors: Hosono T, Kondo A, Kambayashi Y, Homma M Tags: Yakugaku Zasshi Source Type: research

Study of interaction between fluorinated coating glass and the medicines.
In this study, we investigate the adhesion of various syrups to MG made with uncoated glass or glass with a strongly hydrophobic silicone or fluorinated coating in terms of the following formulation parameters: viscosity, surface tension, contact angle, and surface free energy. The contact angles for syrups on the coated glass surfaces were significantly higher than those on the uncoated glass surface. In addition, the relationship between surface tension and contact angle was examined. We found that the contact angle was independent of surface tension for the uncoated glass, while it increased with increasing surface tens...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 25, 2017 Category: Drugs & Pharmacology Authors: Kawano Y, Otsu S, Bamba T, Hanawa T Tags: Yakugaku Zasshi Source Type: research

Chemical analysis of counterfeit hepatitis C drug found in Japan.
Abstract   In January 2017, counterfeits of the hepatitis C drug 'HARVONI(®) Combination Tablets' (HARVONI(®)) were found at a pharmacy chain through unlicensed suppliers in Japan. A total of five lots of counterfeit HARVONI(®) (samples 1-5) bottles were found, and the ingredients of the bottles were all in tablet form. Among them, two differently shaped tablets were present in two of the bottles (categorized as samples 2A, 2B, 4A, and 4B). We analyzed the total of seven samples by high-resolution LC-MS, GC-MS and NMR. In samples 2A, 3 and 4B, sofosbuvir, the active component of another hepat...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 19, 2017 Category: Drugs & Pharmacology Authors: Uchiyama N, Kamakura H, Masada S, Tsujimoto T, Hosoe J, Tokumoto H, Maruyama T, Goda Y, Hakamatsuka T Tags: Yakugaku Zasshi Source Type: research

Pathophysiology Derived from Down Syndrome Related Genes on the 21st Chromosome.
PMID: 28674288 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Minami T Tags: Yakugaku Zasshi Source Type: research

Molecular Mechanism Underlying Abnormal Differentiation of Neural Progenitor Cells in the Developing Down Syndrome Brain.
Abstract  Down syndrome (DS) is caused by trisomy for human chromosome 21. Individuals with DS commonly exhibit mental retardation, which is associated with abnormal brain development. In the neocortex of the DS brain, the density of neurons is markedly reduced, whereas that of astrocytes is increased. Similar to abnormalities seen in DS brains, mouse models of DS show deficits in brain development, and neural progenitor cells that give rise to neurons and glia show dysregulation in their differentiation. These suggest that the dysregulation of progenitor fate choices contributes to alterations in the numbers...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Kurabayashi N, Sanada K Tags: Yakugaku Zasshi Source Type: research

Elucidating Pathogenic Mechanisms of Early-onset Alzheimer's Disease in Down Syndrome Patients.
Abstract  Down syndrome (DS) patients demonstrate the neuropathology of Alzheimer's disease (AD) characterized by the formation of senile plaques and neurofibrillary tangles by age 40-50 years. It has been considered for a number of years that 1.5-fold expression of the gene for the amyloid precursor protein (APP) located on chromosome 21 leading to overproduction of amyloid-β peptide (Aβ) results in the early onset of AD in adults with DS. However, the mean age of onset of familial AD with the Swedish mutation on APP which has high affinity for β-secretase associated with a dramatic increase i...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Asai M, Kawakubo T, Mori R, Iwata N Tags: Yakugaku Zasshi Source Type: research

Comprehensive Analyses of Molecules with Altered Expression in the Brain of a Mouse Model of Down Syndrome for Identification of Pharmacotherapeutic Targets.
Abstract  Down syndrome, caused by the triplication of human chromosome 21, is the most frequent genetic cause of mental retardation. Mice with a segmental trisomy for mouse chromosome 16, which is orthologous to human chromosome 21, exhibit abnormalities similar to those in individuals with Down syndrome and therefore offer the opportunity for a genotype-phenotype correlation. In the current review, I present several mouse lines with trisomic regions of various lengths and discuss their usefulness for elucidating the mechanisms underlying Down syndrome-associated developmental cognitive disabilities. In addi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Ishihara K Tags: Yakugaku Zasshi Source Type: research

Diverse Functions of a Disintegrin and Metalloproteinase with Thrombospondin Motif-1.
Abstract  A disintegrin and metalloproteinase with thrombospondin motif-1 (ADAMTS1) was initially cloned from a colon cachexia cell line. In the last 20 years, novel matrix metalloproteinase (MMP) genes were found, and in addition to their original members (MMPs and membrane-type MMPs), the current MMP family contains a disintegrin and metalloproteinases (ADAMs) and ADAMTS. ADAM and ADAMTS play essential roles in organogenesis as well as various diseases including osteoarthritis. ADAMTS has 19 members and can be divided into several groups according to their substrates. ADAMTS1, the first member of ADAMTS ide...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Hirohata S, Inagaki J, Ohtsuki T Tags: Yakugaku Zasshi Source Type: research

Insight in the Evolution of Therapeutic Monoclonal Antibodies-Fundamental Technologies for Creation and Evaluation of Next Generation mAbs.
PMID: 28674293 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Ishii-Watabe A, Tsumoto K Tags: Yakugaku Zasshi Source Type: research

Antibody Therapeutics: Bench to Bedside.
Abstract  Monoclonal antibodies have been considered promising therapeutic entities due to their highly specific binding to antigens. For oncology in particular, the tumor specific binding of an antibody, without affecting normal tissue, is considered an ideal cancer therapy. Although the proposed mechanism of action of antibody therapeutics varies by targets and indications, antibody-dependent cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), ligand neutralization and inhibition of the signaling pathway are commonly used. Recent advances in genomic information, genetic engineering, and transgenic...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Sakanaka C Tags: Yakugaku Zasshi Source Type: research

Development of a Rapid Identification Method for a Variety of Antibody Candidates Using High-throughput Sequencing.
Abstract  As an alternative to hybridoma technology, the antibody phage library system can also be used for antibody selection. This method enables the isolation of antigen-specific binders through an in vitro selection process known as biopanning. While it has several advantages, such as an avoidance of animal immunization, the phage cloning and screening steps of biopanning are time-consuming and problematic. Here, we introduce a novel biopanning method combined with high-throughput sequencing (HTS) using a next-generation sequencer (NGS) to save time and effort in antibody selection, and to increase the di...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Ito Y Tags: Yakugaku Zasshi Source Type: research

Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.
Abstract  Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Igawa T Tags: Yakugaku Zasshi Source Type: research

Characterization of Therapeutic Monoclonal Antibodies by Using Fc γR-expressing Reporter Cell Lines.
Characterization of Therapeutic Monoclonal Antibodies by Using FcγR-expressing Reporter Cell Lines. Yakugaku Zasshi. 2017;137(7):837-843 Authors: Tada M, Ishii-Watabe A Abstract  Fcγ receptors (FcγRs), which bind to the Fc regions of antibodies, play an important role in antibody effector functions. In humans, there are four types of activating FcγRs: FcγRI, FcγRIIa, FcγRIIIa, and FcγRIIIb. These are expressed on various effector cells such as natural killer (NK) cells, neutrophils and macrophages. FcγRIIIa expressed on NK cells is known to pl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Tada M, Ishii-Watabe A Tags: Yakugaku Zasshi Source Type: research

Thorough Discussion! What Does IPE Bring to Pharmaceutical Education?
Discussion! What Does IPE Bring to Pharmaceutical Education? Yakugaku Zasshi. 2017;137(7):845 Authors: Sugibayashi K, Ishii I PMID: 28674298 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Sugibayashi K, Ishii I Tags: Yakugaku Zasshi Source Type: research

Introduction: Interprofessional Education (IPE) and Pharmaceutical Education: Saitama Interprofessional Education Project.
Abstract  In 2002, the Centre for the Advancement of Interprofessional Education (CAIPE) defined interprofessional education (IPE) as: Interprofessional Education occurs when two or more professions learn with, from, and about each other to improve collaboration and the quality of care. Since 2005, also in Japan, IPE has been introduced within educational institutions to train professionals in healthcare and welfare. Within pharmaceutical education, to acquire the "10 qualities required for pharmacists" indicated by revised model core curricula for pharmaceutical education in 2015, IPE is thought qu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Hosoya O Tags: Yakugaku Zasshi Source Type: research

Systematic and Stepwise Interprofessional Education in Showa University.
Abstract  At Showa University, which consists of the schools of medicine, dentistry, pharmacy, nursing and rehabilitation sciences, systematic interprofessional education was introduced with the cooperation of all 4 schools and through all undergraduate grades with the purpose of training medical staff who can contribute positively to the medical team. In the lower grades, students study the basics of medical team care based on a 4-school joint curriculum of experience learning (such as early exposure) and problem-based learning (PBL) tutorial inside and outside of the university. In the upper grades, student...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Kiuchi Y Tags: Yakugaku Zasshi Source Type: research

The Development of a New IPE Program for Family Pharmacists.
Abstract  Due to the rapid aging of the population, it has become important to ensure the provision of primary health care services. To respond to this challenge, it will be insufficient to offer services only at medical institutions; indeed, there are extremely high expectations for pharmacists because they work in close contact with the population at drugstores and pharmacies. Moreover, the Japanese government intends to promote family pharmacies (pharmacists) that not only prepare drugs but also give advice on health issues. In this context, pharmacists are expected to play new roles that surpass those in ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Maeno T Tags: Yakugaku Zasshi Source Type: research

Effect of IPE on Medical Profession Education and Expectations of Pharmacists-From the Perspective of Nurses.
Abstract  On January 1, 2015, the Interprofessional Education Research Center (IPERC) was opened at the Graduate School of Nursing at Chiba University, while being positioned as one of the Inohana Campus High Functionality Initiatives by the university. As the result of the establishment of an education research center in the nursing graduate school, various changes are coming into view. In particular, the active participation of young instructors of the medical, nursing, and pharmacology departments and university hospital in interprofessional education (IPE) efforts deserve special mention. In addition, IPE...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Sakai I Tags: Yakugaku Zasshi Source Type: research

Global Practices of Interprofessional Education (IPE) and Relevant International Activities.
Abstract  Activities related to interprofessional education (IPE) vary between countries according to local and national health needs and systems. The International Pharmaceutical Federation (FIP) Education Initiative endeavors to provide a global vision in IPE by the sharing of experiences and gathering of evidence collaboratively to facilitate country-level initiatives. The purpose of this paper is to contribute to the further development of IPE activities in pharmacy in Japan through sharing global perspectives and activities related to IPE. FIP Education Initiative published the Interprofessional Educatio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Arakawa N Tags: Yakugaku Zasshi Source Type: research

Current Status of Doping in Japan Based on Japan Anti-Doping Disciplinary Panels of the Japan Anti-Doping Agency (JADA): A Suggestion on Anti-Doping Activities by Pharmacists in Japan.
In conclusion, pharmacists in Japan should pay attention to class S1, S5, and S6 prohibited substances and to the sport events of bodybuilding. Based on this study, sports pharmacists as well as common pharmacists should suggest new anti-doping activities to prevent doping in the future. PMID: 28674304 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Imanishi T, Kawabata T, Takayama A Tags: Yakugaku Zasshi Source Type: research

The Survey of the Compliance Situation to the Antihypertensive Therapy Guideline by Analyzing Japanese National Claims Data.
This study provided a clinically important information and demonstrated the utility of NDB for compliance assessment for therapeutics guideline. PMID: 28674305 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Hagiwara H, Nishikawa R, Fukuzawa K, Tohkin M Tags: Yakugaku Zasshi Source Type: research

A Comparison of the Phosphorus Content in Prescription Medications for Hemodialysis Patients in Japan.
In this study, the phosphorus content of 22 of the most widely prescribed medications that are used in conjunction with HD therapy were examined and differences between branded and generic prescription medications were compared. All samples were selected from medications that are typically prescribed for HD patients. The samples were ground prior to analysis. Phosphorus was measured using the Wako L-Type Phosphate method. All instruments used in the study were calibrated according to the manufacturers' specifications. Amlodipine (15 mg/tablet) and paroxetine (30.0 mg/tablet) were found to contain higher contents of phospho...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Shimoishi K, Anraku M, Uto A, Iohara D, Hirayama F, Kadowaki D, Zingami S, Maruyama T, Otagiri M Tags: Yakugaku Zasshi Source Type: research

Effects of Teicoplanin on the PT-INR Controlled by Warfarin in Infection Patients.
Abstract  Warfarin (WF) shows a number of interactions with other drugs, which alter its anticoagulant effects. The albumin binding interaction is one such pharmacokinetic mechanism of drug interaction with WF, which induces a rise in the free WF concentration and thus increases the risk of WF toxicity. Teicoplanin (TEIC) is an anti-methicillin-resistant Staphylococcus aureus drug, which also binds strongly to albumin in the plasma. Therefore, co-administration of TEIC may displace WF from the albumin binding site, and possibly result in a toxicity. The present study was performed to investigate the drug-drug...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Nakano T, Nakamura T, Nakamura Y, Irie K, Sato K, Matsuo K, Imakyure O, Ogata K, Mishima K, Kamimura H Tags: Yakugaku Zasshi Source Type: research

Improved Clinical Outcomes in Patients with Positive Blood Culture by Proactive Intervention of Antimicrobial Use-Impact of Antimicrobial Stewardship Program Implementation on Clinical Practice.
Abstract  Bacteremia is one of the most serious infectious illness resulting from nosocomial infection. Therefore, appropriate antimicrobial chemotherapy should be provided as soon as possible to patients exhibiting symptoms of infectious disease and having positive blood culture results. Antimicrobial stewardship (AS) guidelines were recently released by the Infectious Diseases Society of America. The guidelines recommend "proactive intervention and feedback" as one of the core strategies for implementing optimal antimicrobial drug use to improve patient outcomes in clinical settings. We began usin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 5, 2017 Category: Drugs & Pharmacology Authors: Yamada T, Kagami K, Imai S, Akizawa K, Iwasaki S, Fukumoto T, Ishiguro N, Iseki K Tags: Yakugaku Zasshi Source Type: research

Study on Students' Impression Data in Practical Training Using Text Mining Method-Analysis of Considerable Communication.
In conclusion, it was suggested that students attempted active patient-centered communication in practical hospital training, while they were conscious of listening closely in patient counseling in practical pharmacy training. PMID: 28652513 [PubMed - as supplied by publisher] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 26, 2017 Category: Drugs & Pharmacology Authors: Teramachi H, Sugita I, Ino Y, Hayashi Y, Yoshida A, Otsubo M, Ueno A, Katsuno H, Noguchi Y, Iguchi K, Tachi T Tags: Yakugaku Zasshi Source Type: research