[Inhibitory Effects of Dabigatran on Airway Inflammation Induced by Lipopolysaccharide in Mice].
In this study, we investigated the effects of anti-coagulants on lipopolysaccharide (LPS)-induced airway inflammation in mice. A/J mice were exposed to LPS, a bacterial endotoxin, intranasally and accumulation of inflammatory cells, TNF-α, C-X-C motif chemokine (CXCL) 1, and osteopontin in bronchoalveolar lavage fluid (BALF) was monitored by flow cytometry and an enzyme-linked immunosorbent assay. LPS exposure induced airway neutrophilia and accumulation of TNF-α, CXCL1, and osteopontin in BALF. This LPS-induced airway inflammation was not relieved using a corticosteroid, fluticasone propionate (FP), or a direc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 14, 2020 Category: Drugs & Pharmacology Authors: Kimura G, Takahashi R, Nagamoto A, Yoshino K, Ueda K, Nishimoto Y, Kizawa Y Tags: Yakugaku Zasshi Source Type: research

[Synthesis of Cyclic Compounds Containing Aminobenzenesulfonamide].
Abstract This review, based on my research work, introduces and summarizes the synthesis and characterization of novel cyclic compounds containing aminobenzenesulfonamide. The review discusses the (1) development of sequential Nicholas and Pauson-Khand reactions for the synthesis of unique polyheterocyclic compounds, (2) production of 2-aminobenzenesulfonamide-containing cyclononyne (ABSACN) as a multifunctional click cycloalkyne agent, and (3) improvement of the intramolecular Pauson-Khand reaction of the nitroarene-enyne substrate for the synthesis of cyclopenta[c]piperidine alkaloids. This research work will fa...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Kaneda K Tags: Yakugaku Zasshi Source Type: research

[Study of the Mechanisms of Maintaining the Transparency of the Lens and Treatment of Its Related Diseases for Making Anti-cataract and/or Anti-presbyopia Drugs].
Abstract The lens of the eye is an avascular and anuclear tissue that serves to focus objects on the retina. Cataract is opacity within the clear lens that changes the transparency and refractive index of the lens causing significant visual impairments. These impairments can severely restrict the ability to carry out daily activities. Cataracts is common among elderly person occurring in more than 80% of patients aged 80 or older. Notably, we have recently identified key compounds that are effective against cataract formation. Presbyopia is also an ocular disease that typically develops in people over the age of 4...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Nakazawa Y Tags: Yakugaku Zasshi Source Type: research

[Development of a General Synthetic Method for Organoselenium Compounds Utilizing Copper Catalyzed Cross Coupling and C-H Bond Activation].
This article reviews our studies to develop of copper-catalyzed C-Se bond formation reactions via cross coupling and C-H activation. A number of unsymmetrical and symmetrical diaryl selenides were synthesized via Se-arylation of diaryl diselenides or selenium powder with triarylbismuthanes under aerobic conditions, achieving moderate to excellent yields. When the reaction of triphenylbismuthane with elemental Se was monitored with gas chromatography, diphenyl diselenide and diphenyl selenide formation was confirmed. Subsequently, 1-pot 2-step reactions were performed under mild conditions to obtain 3-selanyl imidazo[1,2-a]...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Matsumura M Tags: Yakugaku Zasshi Source Type: research

[Pharmaceutical Research and Education].
Abstract The true central aim of pharmaceutical research and education is to strive for the patient's satisfaction, i.e., "for the sake of the patient". Our research focuses to bridge the gap between the ideal and current situation in pharmaceutical science. We also investigated/questioned the united roles of pharmacists and pharmacies, with the ambition of changing the work culture of pharmacists. This paper reviews the history of our research and discusses the future of pharmaceutical research and education. PMID: 32879243 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceuti...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Arai K Tags: Yakugaku Zasshi Source Type: research

[Redox Signaling and Reactive Sulfur Species to Regulate Electrophilic Stress].
Abstract Humans are exposed to various xenobiotic electrophiles on a daily basis. Electrophiles form covalent adducts with nucleophilic residues of proteins. Redox signaling, which consists of effector molecules (e.g., kinases and transcription factors) and redox sensor proteins with low pKa cysteine residues, is involved in cell survival, cell proliferation, quality control of cellular proteins and oxidative stress response. Herein, we showed that at a low dose, xenobiotic electrophiles selectively modified redox sensor proteins through covalent modification of their reactive thiols, resulting in activation of a ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Kanda H, Kumagai Y Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Capturing Accurate HbA1c Value Using Medical Information and Communication Technology by Pharmacist].
In this study, we investigated the usefulness of acquisition and utilization of precise medical information from diabetic patients using Kibitan Health Net. The subjects of this study were 18 patients having type 2 diabetes mellitus with a mean HbA1c level of 7.4±1.0 (%). We compared the HbA1c level captured by the pharmacists from the patients (total 72 times) with that updated on Kibitan Health Net (41 times correctly captured by the pharmacists). We next compared the HbA1c levels between the "group that could listen to accurate laboratory data" and the "group that could not listen to accurate labor...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Sugawara H, Ohara H, Hamada M, Shimanuki E, Machino S Tags: Yakugaku Zasshi Source Type: research

[Residual Property of SI-613, a Novel Drug for Osteoarthritis, in Knee Joint].
In this study, we evaluated the properties of residual SI-613 in the knee joint after an intra-articular (IA) administration. After IA administration of fluorescent labeled SI-613 (FA-SI-613) or fluorescent labeled hyaluronic acid (FA-HA) to rabbits, fluorescence intensities in the synovial membrane and cartilage were higher in the FA-SI-613 group until 7 d after administration than in the FA-HA group. After IA administration of radiolabeled SI-613 (14C-SI-613) to rabbits, the radioactivity remained in the joint cavity and the joint tissues such as synovial membrane and cartilage until 84 d after administration. This resid...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Ishii S, Yoshioka K, Morita D Tags: Yakugaku Zasshi Source Type: research

[Multivariate and Bayesian Network Analyses of the Factors Causing Belief Conflicts That Deteriorate Teamwork and Cause Stress among Pharmacists during Proposals and Inquiries of Prescription].
Abstract Pharmacists working in collaboration with doctors are mainly involved in proposals and inquiries of prescription. At such times, belief conflicts are expected to deteriorate teamwork and induce stress. However, there is no strong evidence for this. To clarify factors resulting in belief conflicts, we conducted a survey among 594 pharmacists working at medical institutions in Gifu City and belonging to Gifu Pharmaceutical Association or Gifu Prefectural Society of Hospital Pharmacists between January 2019 and April 2019. The items of the survey were gender, place of employment, pharmacist working experienc...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Hayashi T, Tachi T, Takaoka M, Noguchi Y, Teramachi H Tags: Yakugaku Zasshi Source Type: research

[Adsorption Behavior of Water on Virgin and Modified Cyclodextrin].
Abstract Relationship between water molecules and parent and hydroxypropylated cyclodextrins (denoted as CD and HP-CD) was assessed in this paper. The trends in ad-desorption isotherms of CD for water molecule were quite different compared to those of HP-CD. Ad-desorption isotherms of CD showed the hysteresis under our experimental conditions. The molar ratio of hydration (R-value) using α-CD, β-CD, γ-CD, HP-α-CD, HP-β-CD, and HP-γ-CD was 7.1, 11.4, 13.5, 12.5, 14.0, and 16.7, respectively. These results indicated that the adsorption capability of water molecule of HP-CD was great...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Ogata F, Hayabuchi R, Saenjum C, Nakamura T, Kawasaki N Tags: Yakugaku Zasshi Source Type: research

[Pharmaceutical Properties of Anti-inflammatory Analgesic Patches Using Acrylic Polymer].
Abstract The mock patches were prepared with novel acrylic polymers as adhesive layer where biphenyl-4-ylacetic acid (BAA) or 2-(2-fluorobiphenyl-4-yl) propanoic acid (FPA) was used as model active pharmaceutical ingredients (APIs). In addition, the mock patches were formulated with typical ester ingredients for transdermal dosage forms. The molecular state of the model APIs in the adhesive layer was observed by polarized microscope and microscopic Raman spectroscopy, which contains both conventional and low frequency (LF) region. Crystallization behavior would be depended on the interaction between API and polyme...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Gato K, Shikaku R, Kato S, Yoshimura-Fujii M, Koide T, Fukami T Tags: Yakugaku Zasshi Source Type: research

[Relevance between Methods of Obtaining Drug Information and the Utilization of the Information in Community Pharmacies -Research on Awareness of Drug Information of "Increased Risk of Developing Diabetes in Patients Treated with HMG-CoA Reductase Inhibitors" in Community Pharmacies].
[Relevance between Methods of Obtaining Drug Information and the Utilization of the Information in Community Pharmacies -Research on Awareness of Drug Information of "Increased Risk of Developing Diabetes in Patients Treated with HMG-CoA Reductase Inhibitors" in Community Pharmacies]. Yakugaku Zasshi. 2020;140(9):1185-1193 Authors: Doi H, Yamato M, Ohsawa M, Nakagawa N, Chonan KI Abstract Lipid lowering therapy using statins prevents the risk of cardiovascular events. However, since the year 2000, there have been some reports that statins increased the risk of developing diabetes (SIRDD). It...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Doi H, Yamato M, Ohsawa M, Nakagawa N, Chonan KI Tags: Yakugaku Zasshi Source Type: research

[Survey on the Pharmacists Perceptions of Clinical Trial Literature Accessibility].
Abstract The purpose of this study is to understand the reading habits of Japanese pharmacists regarding clinical trial literature in 2014. Questionnaires were mailed to 1997 pharmacists in Miyagi Prefecture. Six hundreds and five [342 (56.5%) hospital pharmacists and 254 (42.0%) community pharmacists] responded to questionnaires (Response rate: 30.3%). Regarding the question, "Do you habitually read clinical trial literature?", 19.5% of hospital and 8.3% community pharmacists responded "yes", respectively, which showed both pharmacists are not habitual readers of clinical trial literature. Tha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 5, 2020 Category: Drugs & Pharmacology Authors: Ishii Y, Nakagawa N, Obara T, Ohara H, Kurita S, Murai Y Tags: Yakugaku Zasshi Source Type: research

[Conjugation to Branched Glycerol Oligomers, a Novel Strategy for Extremely Hydrophobic Agents].
Abstract Ascertaining the absorption, distribution, metabolism, and excretion (ADME) profile of drugs is one of the most crucial factors in the process of drug discovery. Since it is important to combine water solubility and cell permeability within the compound to achieve the desired ADME properties, an appropriate balance between lipophilicity and hydrophilicity is required. It is often necessary to facilitate hydrophilicity of very hydrophobic candidates, because quite lipophobic molecules are rarely hit as positive in molecular-targeted or cell-based screenings. For that purpose, it has been popular to conjuga...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Miyamoto L, Abe S, Nemoto H, Tsuchiya K Tags: Yakugaku Zasshi Source Type: research

[Development of DDS Actively to Overcome the Blood-brain Barrier in the Region of Ischemic Stroke].
Abstract We previously showed that increased permeability of the blood-brain barrier (BBB) after ischemic stroke enables extravasation of nano-sized liposomes and accumulation in the ischemic region, and that delivery of neuroprotective agents using liposomal drug delivery systems (DDS) is applicable for treating cerebral ischemia/reperfusion (I/R) injury. However, entry of liposomes into the brain parenchyma was limited in the early stages after I/R possibly due to microvascular dysfunction induced by pathological progression. As such, new approaches to overcome the BBB are needed. Leukocytes can pass through inf...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Fukuta T, Kogure K Tags: Yakugaku Zasshi Source Type: research

[Particle Design Strategies for Developing Patient Centric Dosage Form Preparations].
Abstract Novel dosage form designs aiming at patient centric drug therapy are summarized here based on my carrier research in this field. The common key word for this research is particle design. The topics will be divided into two parts, based on the type of particle: coarse particles (powder) and colloidal particles. The former includes the preparation and characterization of functional particles prepared using a spray dryer. Solid dispersions, solvent deposition particles and dry emulsion systems are described. Polymer coated liposomes are described as a useful drug delivery carrier in several administration ro...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Takeuchi H Tags: Yakugaku Zasshi Source Type: research

[Need for Prescription Suggestions for Long-term Inpatients in the Psychiatric Ward].
In conclusion, our findings show that ward pharmacists' services were necessary not only for the inpatients hospitalized for 8 weeks. PMID: 32741860 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Shin K, Kobayashi D, Kawashiri T, Ushijima Y, Moritaka K, Yanai H, Ichiki Y, Murakami A, Kanazawa Y, Kamimura H, Shimazoe T Tags: Yakugaku Zasshi Source Type: research

[Significant Changes Associated with the Transition from Outsourcing to In-hospital Therapeutic Drug Monitoring of Novel Antiepileptics].
Abstract For many of the novel antiepileptics, immunoassays, used for routine therapeutic drug monitoring (TDM), cannot be used. We could monitor eight novel antiepileptics using an LC/MS method since July 2017. The purpose of this study was to evaluate the significant changes associated with the transition from outsourcing to in-hospital monitoring of novel antiepileptics. The number of measurements of novel antiepileptics was significantly increased during the first (p
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Suetsugu K, Yamamoto N, Shigematsu T, Kobayashi D, Tsuchiya Y, Nakayama Y, Tsuji T, Watanabe H, Kanaya A, Masuda S, Egashira N Tags: Yakugaku Zasshi Source Type: research

[Association Suvorexant and Ramelteon Use with the Risk of Falling: A Retrospective Case-control Study].
Abstract Sedative hypnotics are among the classes of drugs reported to influence falls. However, the effects of the sedative hypnotic drugs, suvorexant and ramelteon, on falls are not well known. Therefore, we conducted this retrospective case-control study to examine the association of the use of these two sedative hypnotics with the risk of falls. Conducted at the Sapporo Medical University Hospital in Japan, our study included 360 patients with fall incidents and 819 randomly selected control patients. Patients in the fall group were significantly older with a lower body mass index, and had a history of falls, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Ishigo T, Takada R, Kondo F, Ibe Y, Nakano K, Tateishi R, Fujii S, Katano S, Kitagawa M, Kimyo T, Nakata H, Hashimoto A, Miyamoto A Tags: Yakugaku Zasshi Source Type: research

[Effects of Medium Chain Triglycerides Intake on Lipid Metabolism and Intestinal Disaccharidase Activities in Rats].
Abstract It has been reported that medium-chain triglyceride (MCT) have various physiological functions, such as anti-obesity and hypolipidemic effects. They can also elicit increased disaccharidase activity and intestinal cell proliferation. However, a meta-analysis of randomized controlled trials, comparing the effects of MCT on weight loss and body composition, detected commercial bias. Additional research on the physiological functions is needed in order to have conclusive evidence. Thus, we sought to evaluate the various functions of MCT by conducting a feeding study in rats. Rats fed a diet containing 15% (w...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Suzuki E, Oshima M, Sonotsuka M, Hayashitani H, Ohtani S, Kishida K Tags: Yakugaku Zasshi Source Type: research

[Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 1)].
In this study, we investigated that the hygroscopicity of reagents could cause the changes in the compounds' purity depending on increasing their water content. Twenty-one standard products used for the crude-drug test in JP were examined by water sorption-desorption analysis, and ginsenosides and saikosaponins were found to be hygroscopic. To prepare a sample solution of saikosaponin b2 for qNMR analysis, samples need to be maintained for 18 h at 25°C and 76% relative humidity; further, samples need to be weighed at the same humidity for the qNMR analysis. PMID: 32741864 [PubMed - in process] (Source: Yakugaku Za...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Uchiyama N, Hosoe J, Miura T, Sugimoto N, Ishizuki K, Yamada Y, Iwamoto Y, Suematsu T, Komatsu T, Maruyama T, Igarashi Y, Higano T, Shimada N, Goda Y Tags: Yakugaku Zasshi Source Type: research

[Establishment of a Novel Method to Evaluate Water Permeation Rates by Combining the Dynamic Contact Angle and Thermographic Approach: Significance of Disintegration Properties of Orally Disintegrating Tablets].
Abstract The purpose of the present study was to establish a novel method to evaluate water penetration rates by combining the local dynamic contact angle and thermographic approach to characterize water conduction properties in orally disintegrating (OD) tablets. The OD tablet tester OD-mate was used to measure the disintegration times of OD tablets. Other formulation characteristics, such as tablet hardness and friability, were evaluated. By examining three formulation characteristics, such as the disintegration time, tablet hardness, and friability, of 33 OD tablets for generic drugs, four characteristic OD tab...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Suzuki T, Kurano T, Kanazawa T, Suzuki N Tags: Yakugaku Zasshi Source Type: research

[Effectiveness of Topical NSAIDs in a Gastric Cancer Patient with Bone Metastasis Pain during Therapy with Opioids and Oral NSAIDs].
Abstract Cancer patients often suffer from severe pain related to bone metastasis. We encountered a patient in whom the addition of topical non-steroidal anti-inflammatory drugs (NSAIDs) for persistent pain related to bone metastasis during therapy with opioids and oral NSAIDs reduced pain, improving activities of daily living (ADL). Fentanyl patches, celecoxib, denosumab, and topical NSAIDs (loxoprofen tape, felbinac) were administered to a 72-year-old patient with gastric cancer and pain related to bone metastasis. Pain control was favorable, with a numerical rating scale (NRS) score of 2 and Japanese version Su...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Terayama K, Hamana M, Tsuchiya M, Watanabe T, Enomoto H, Yasuno N, Miura K, Ohta K, Watanabe S Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Interaction between Phosphate Ion and Metal Complex-layered Hydroxide].
Abstract A nickel-aluminium-zirconium complex-layered hydroxide (NAZ), which was synthesized using each inorganic sulfate mixing ratio of 0.9 : 1.0 : 0.1, was prepared and calcined at different temperatures. The physicochemical properties of the NAZ were analyzed by scanning electron microscopy, specific surface area, number of hydroxyl groups, and pore volume. The specific surface area, number of hydroxyl groups, and pore volume of NAZ was 51.9 m2/g, 1.08 mmol/g, and 0.27 μL/g, respectively. The amount of phosphate ion adsorbed onto NAZ was higher than that onto calcined NAZ at different temperatures. Therefor...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Ogata F Tags: Yakugaku Zasshi Source Type: research

[State-of-the-art Technologies Innovative to the World of Pharmaceutical Sciences].
PMID: 32741868 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Miyamoto L, Sato H Tags: Yakugaku Zasshi Source Type: research

[Linkage of Drug Resistance and Metabolome Shift in Renal Cell Carcinoma Cells].
Abstract Metabolome analysis is an approach to investigate cell characteristics from the metabolites that are constantly produced and changed by those cells. We conducted a metabolome analysis of the response of 786-O renal cell carcinoma (RCC) cells to histone deacetylase (HDAC) inhibitors, which are expected to increase anticancer drug sensitivity, and compared the response with that of drug-resistant cells. Trichostatin A (TSA), an HDAC inhibitor, increased the sensitivity of 786-O cells to sunitinib. Moreover, TCA cycle and nucleotide metabolism of the cells were promoted. The findings that acetylated p53 (act...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Sato H Tags: Yakugaku Zasshi Source Type: research

[Novel Technology for Studying Insulin Secretion: Imaging and Quantitative Analysis by a Bioluminescence Method].
Abstract We developed a method of video-rate bioluminescence imaging to visualize proteins secreted from living cells. A protein of interest was fused to Gaussia luciferase (GLase), and the luminescence signals of secreted GLase with coelenterazine (luciferin) were visualized at a video-rate of 30-500 ms/frame by using a water-cooled EM-CCD camera. We established a subclonal rat INS-1E cell line, named iGL cells, stably expressing the fusion protein of insulin and GLase (Insulin-GLase). By stimulation with high glucose, 3D-cultured iGL cells showed synchronized oscillatory secretion of insulin for over 1 h, as sim...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Suzuki T, Kanamori T, Inouye S Tags: Yakugaku Zasshi Source Type: research

[Monoamine Mapping Using Mass Spectrometry Identified New Monoamine-rich Brain Nuclei].
Abstract Monoamine neurotransmitters are released by specialized neurons that regulate behavioral and cognitive functions. Although localization of monoaminergic neurons in the brain is well known, the distribution, concentration, and kinetics of monoamines remain unclear. We used mass spectrometry imaging (MSI) for simultaneous and quantitative imaging of endogenous monoamines to generate a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels. We observed several nuclei rich in both 5-HT and a catecholamine (DA or NE). Additionally, we analyzed de novo monoamine synthesis or fluct...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Sugiyama E, Sugiura Y Tags: Yakugaku Zasshi Source Type: research

[Use of Transsynaptic Viral Tracers for Observing Neural Circuit Control of Physiological Responses].
Abstract Central neural circuits in the brain receive and integrate environmental and internal information to enable the animals to execute appropriate behaviors and physiological responses. Communication between the brain and peripheral organs via peripheral neural circuits maintains energy homeostasis in the body. Therefore it is important to investigate the anatomical organization of central and peripheral neural circuits for elucidating the mechanisms of energy homeostasis. Transsynaptic viral tracers can travel through connected neurons via synaptic connections and have been used to delineate the anatomical o...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Kondoh K Tags: Yakugaku Zasshi Source Type: research

[Manipulating Living Systems by Light].
Abstract The human genome consists of more than 20000 genes and is essential for all biological phenomena. To understand these biological phenomena, including diseases, and to be able to modify them, approaches that enable optical control of the genome may be useful. Recently, we developed an optogenetic tool, named photoactivatable Cas9 (PA-Cas9). We divided Cas9 nuclease from the CRISPR-Cas9 system into two fragments and connected photo-inducible dimerization proteins, named Magnet system, to the fragments, leading to the development of PA-Cas9 of which nuclease activity is switchable with light. PA-Cas9 allows ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 5, 2020 Category: Drugs & Pharmacology Authors: Sato M Tags: Yakugaku Zasshi Source Type: research

The Effect of Increased Free Concentrations of Warfarin Due to Protein-binding Substitution in a Combination of Tolvaptan on the PT-INR.
In this study, we investigated the drug-drug interactions between warfarin and tolvaptan by measuring warfarin blood concentrations in 18 patients who received warfarin therapy and in 24 who received warfarin + tolvaptan therapy. The free warfarin concentrations significantly increased in patients who were also receiving oral tolvaptan (p = 0.04). In vitro albumin-binding experiments showed that the free warfarin concentrations significantly increased with the addition of tolvaptan, in a dose-dependent manner, through albumin-binding substitution (approximately 2.5 times). Both clinical and in vitro data showed that tolvap...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 20, 2020 Category: Drugs & Pharmacology Authors: Saito M, Maeda T, Ichihara T, Iwao T, Suzuki T Tags: Yakugaku Zasshi Source Type: research

[One Function of Advanced Pharmaceutical Management at Family Pharmacies: Proposals from a Home Pharmaceutical Care Pharmacy].
PMID: 32612044 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Hirohara M, Ijuin K Tags: Yakugaku Zasshi Source Type: research

[Consideration of Advanced Pharmaceutical Control Functions through Pharmacy-provided Home Pharmaceutical Care].
Abstract In October 2015, the Ministry of Health, Labour and Welfare of Japan newly included "health support functions" and "advanced pharmaceutical control functions" as part of "primary-care pharmacy" in the pharmacy vision for patients. "Health support functions" were defined as recommending that patients seek medical consultations, introducing them to relevant medical institutions, and contributing to disease prevention and health support among local residents, apart from health counseling and the consolidation of a framework for the appropriate selection and supply of a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kimura M Tags: Yakugaku Zasshi Source Type: research

[At-home Palliative Care Supported by Interprofessional Work].
We report the current situation and challenges with respect to interprofessional work and the roles of community pharmacists in a home-care setting. PMID: 32612046 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Shiraishi T Tags: Yakugaku Zasshi Source Type: research

[Support for Children with Difficulties in Living at Home: The Role of Community Pharmacies in Pediatric Home-care Systems].
Abstract Our pharmacy is a support center for home-care dispensing with a sterile dispensary, actively participating in a regional collaboration among medical treatment, nursing, and social care. We have supported hundreds of home-care patients, most of whom were elderly people living at home but a dozen or so were pediatric patients. Although the primary diseases of the children varied, what they had in common was a high degree of medical dependence and it was difficult to move them. At the same time, a caregiver had to be in constant attendance because medical care was intermittent. At the pharmacy, they faced l...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kawana M Tags: Yakugaku Zasshi Source Type: research

[The Role of Pharmacists in Home Medical Care of Patients with Heart Failure].
Abstract In recent years, home medical care has been strongly promoted. As a consequence, the conditions managed in home medical care have become increasingly diverse. Heart failure is one of the most common disorders after malignant diseases. Patients with chronic heart failure (CHF) are often forced into hospitalization because of the inability to control symptoms with oral medications, even though they hope to stay at home. Recently, we have experienced a case where the patient required continuous administration of dobutamine at home. In order to carry out CHF care at home successfully, it is necessary to adjus...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Sakuma E, Kawauchi J, Gyoda Y, Oikawa Y, Watanabe J Tags: Yakugaku Zasshi Source Type: research

[Advanced Pharmaceutical Management Functions in Home Pharmaceutical Care].
Abstract In 1994, community pharmacists first started patient-visiting services under health insurance coverage. There are a wide variety of home-care patients for whom pharmacists provide care. They include elderly patients with chronic disease, pediatric home-care patients with or without special needs, patients with dementia, cancer patients receiving palliative care, and others. Pharmacies engaging in home pharmaceutical care should establish an adequate system in terms of the following aspects: 1) number of pharmacists; 2) availability of a sterile dispensing room; 3) stock of medical narcotics; and 4) stock ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kushida K, Hirohara M Tags: Yakugaku Zasshi Source Type: research

[Current Status of and Countermeasures against Infectious Diseases].
PMID: 32612050 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kuroda T, Matsuzawa A, Kuge S Tags: Yakugaku Zasshi Source Type: research

[Development of Medicines for Infectious Diseases -Malaria].
Abstract In developed countries, it is said that "threats of infectious diseases are already thought as things of the past". However, as you can see in the case of Ebola hemorrhagic fever that occurred in West Africa, this is a big mistake. Among infectious diseases, only smallpox has been successfully eradicated worldwide. In addition to the three major infectious diseases of HIV/AIDS, tuberculosis, and malaria, there is another group called emerging and reemerging infectious diseases. Recently, neglected tropical diseases (NTDs) have been listed as threats by the WHO, as have drug-resistant bacteria. T...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kita K Tags: Yakugaku Zasshi Source Type: research

[Emerging and Re-emerging Virus Infections in Japan: Dengue Fever, Zika Virus Disease, and SFTS].
Abstract A sporadic but autochthonous dengue fever outbreak occurred in Tokyo in 2014, although the dengue virus is not in general circulation in Japan. Another lethal infectious disease, known as severe fever with thrombocytopenia syndrome (SFTS), was discovered to be endemic to Japan in January 2013. More than 400 patients with SFTS have been reported so far. The fatality rate of SFTS is approximately 30%. Also in 2014, a large outbreak of mosquito-borne Zika virus infections occurred in the South and Central parts of the American continent. Transplacental infection of a fetus with Zika virus occurs when pregnan...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Saijo M Tags: Yakugaku Zasshi Source Type: research

[Re-emerging Rubella Epidemic and Public Health Measures in Japan].
Abstract Although rubella is usually a mild, febrile illness, and up to 50% of rubella infections are asymptomatic, congenital rubella syndrome (CRS) can occur in the developing fetus of a pregnant woman infected with rubella virus (RV) in early pregnancy. After a rubella outbreak from early 2012 to late 2013 in Japan, another outbreak re-emerged from mid-2018 in the Tokyo metropolitan area and other large cities. In 2018, and up to epidemiological week (EW) 25 in 2019, more than 4000 rubella cases had been reported. Three CRS cases were also reported up to EW 24. Seroepidemiological surveys among Japanese residen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Oishi K, Satoh H, Tanaka-Taya K Tags: Yakugaku Zasshi Source Type: research

[Initiatives to Combat Infectious Diseases through Regional Cooperation].
Abstract The rate of detection of various resistant bacteria has recently increased, though the development of antimicrobial agents has been delayed. In the hospital setting, an antimicrobial stewardship team (AST) works to assure that resistant bacteria do not appear, while an infection control team (ICT) works to assure these resistant bacteria do not spread. Additionally, ICT and AST work together on the appropriate use of antimicrobial agents. In order to combat infectious diseases regionally, it will be important for hospitals and pharmacies to share such information as infection control, consumption trends o...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Nakai H Tags: Yakugaku Zasshi Source Type: research

[Infection Control Standards Expected in the Primary Care Pharmacy].
Abstract In medical care, qualified physicians, nurses, and pharmacists have come to be recognized as a team integral to a patient's success, and this team approach to medical care has become popular. In the infectious disease field, more hospitals are practicing antimicrobial stewardship as a team, in addition to the conventional infection control team (ICT). As a result, infectious disease chemotherapy pharmacists are in demand. However, this specific qualification is hard to acquire for pharmacists working in a primary care pharmacy. The problem of multidrug-resistant bacteria is of vital interest today. The Na...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Fujimura S Tags: Yakugaku Zasshi Source Type: research

[Prediction of the Crystal Growth Mechanism of Aspirin Using Molecular Simulations].
In this study, we used aspirin as a model compound. By performing simulations based on known crystal structure data, we trained the simulation algorithm to produce the cubic and plate-like morphologies of crystals actually obtained. By these methods, we showed that the crystal plane of the crystal form actually obtained coincides with the characteristic crystal plane obtained by simulation. Furthermore, to consider the influence of the crystallization solvent on crystal growth, we simulated adsorption of solvent molecules on characteristic crystal planes. The difference in adsorption energy of the solvent molecules prevent...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Hatanaka T, Yoshihashi Y, Ito M, Terada K, Yonemochi E Tags: Yakugaku Zasshi Source Type: research

[Liver Injury Risk Factors in Amyotrophic Lateral Sclerosis Patients Treated with Riluzole].
In conclusion, treatment of ALS patients with riluzole, smoking habits, and concurrent use of CYP1A2 inhibitors are independent liver injury risk factors. Further studies on liver injury are warranted in ALS patients treated with riluzole to comprehensively understand the underlying mechanisms of riluzole-associated liver toxicity. PMID: 32612057 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Kawano C, Isozaki Y, Nakagawa A, Hirayama T, Nishiyama K, Kuroyama M Tags: Yakugaku Zasshi Source Type: research

[Evaluation of the Tolerability of Gemcitabine and Cisplatin Combination Chemotherapy with a Small Quantity of Replacement Fluid for Biliary Tract Cancer].
This study suggests that GC with a small amount of replacement fluid could be performed tolerability. But we need to be careful about choosing patients such as patients who can drink 1 L orally and patients who can be treated as outpatients. PMID: 32612058 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Ichimura T, Nawata S, Ichikura D, Murakami K, Usuda M, Kawashima W, Minemura A, Sasaki T Tags: Yakugaku Zasshi Source Type: research

[Efficacy of Saxagliptin for Blood Glucose Control in Hemodialysis Patients with Diabetes].
Abstract Studies on the drug saxagliptin (marketed in Japan since 2013) suggest favorable efficacy in hemodialysis patients, but included small sample sizes. Noting that some hemodialysis patients at our medical institution had been switched to saxagliptin 2.5 mg from treatment with other dipeptidyl peptidase-4 inhibitors, we decided to evaluate the effects of switching to saxagliptin on blood glucose control in these patients. The study included 11 patients. Before switching drugs, six of the patients used teneligliptin 20 mg and five used linagliptin 5 mg. Mean glycated albumin (GA) from before to 4 months after...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Sakurai J, Satoh S, Hase M, Takahashi T, Ojima F, Andou S, Kishikawa Y, Ishizawa F, Satoh J Tags: Yakugaku Zasshi Source Type: research

[Is Concomitant Therapy with Acetaminophen and Low-dose Aspirin a Risk Factor for CKD Progression? A 6-Year Cohort Study].
Abstract Concomitant therapy with acetaminophen (APAP) and low-dose aspirin is often used in clinical settings; however, it is unclear whether this combination is involved in the progression of chronic kidney disease (CKD). We hypothesized that concomitant therapy with APAP and low-dose aspirin may cause CKD progression. We carried out a retrospective 6-year cohort study that included all patients who received low-dose aspirin from January 2011 to December 2016 at Kaetsu Hospital. Primary outcome was defined as CKD progression at the end of the study compared with baseline. Among the 441 patients treated during th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Mitsuboshi S, Yamada H, Yamazaki S, Kobayashi M, Ueno K, Nagai K Tags: Yakugaku Zasshi Source Type: research

[Analysis of Learner Characteristics Affecting Learning Outcomes in the Field of Pharmaceutical Law].
Abstract To contribute to research on the effective practice of pharmaceutical law, we analyzed the learner characteristics that influence learning outcomes in this field at Kitasato University School of Pharmacy. Specifically, we conducted a forced entry multiple regression analysis. The explanatory variables were the learner's gender, course, university entrance examination format, course year progression, completion of related subjects, and submission of class quizzes, while examination performance in pharmaceutical law was the response variable. The learners' course of study and submission of class quizzes wer...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2020 Category: Drugs & Pharmacology Authors: Yamamoto D, Itoh T, Suzuki J Tags: Yakugaku Zasshi Source Type: research

[Survey on the Attitudes and Concerns of Nursing Home Staff Regarding Assistance of Medication Administrations in Japan: A Questionnaire Survey].
Abstract Care workers at care facilities play an important role in providing medication-administration assistance, and in medication risk management. Nevertheless, research has not made clear the specific concerns that care workers have at work sites, as well as the extent of their burdens. Thus, we conducted a questionnaire survey from October 1 through October 31, 2014 for staff who provide medication-administration assistance at for-pay elderly person homes about the concrete concerns and burdens with regards to the assistance. A total of 1,677 respondents were analyzed: 228 nurses and 1,449 care workers. Resul...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 2, 2020 Category: Drugs & Pharmacology Authors: Maki H, Park H, Miki A, Satoh H, Konishi Y, Sawada Y Tags: Yakugaku Zasshi Source Type: research