[New Approach to Promoting Healthy Life-span with Pharmacies and Pharmaceutical Distributors-To Support the Maintenance and Promotion of Independent Health by Local Residents].
PMID: 30930378 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Yoshikawa Y, Takegami S, Inoue M Tags: Yakugaku Zasshi Source Type: research

[Promoting the "Revitalization of Healthy Life Expectancy" with the Town of Anamizu].
[Promoting the "Revitalization of Healthy Life Expectancy" with the Town of Anamizu]. Yakugaku Zasshi. 2019;139(4):513-517 Authors: Miyamoto K, Ozaki T, Onishi K, Takehana H, Tonoda K, Hara M Abstract The town of Anamizu in Housu District, Ishikawa Prefecture, in the northern part of the Noto Peninsula, has 8600 residents of whom 45.4% are 65 years or older, making it a region with an aging population. A project was launched to "make Anamizu a town known for the good health and long life" of its citizens. The project involved, among other things, health classes run by health outrea...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Miyamoto K, Ozaki T, Onishi K, Takehana H, Tonoda K, Hara M Tags: Yakugaku Zasshi Source Type: research

[Local Contributions and Regional Alliances by Pharmaceutical Wholesalers].
Abstract Recently, we considered the term 'integrated community care system' and aimed to play a role in the process by joining various healthcare occupations as part of this new integrated system. Given our company's ties with people involved in a range of occupations, we are poised to play a liaison role. We called a "face-to-face meeting" with local healthcare practitioners to begin exploring this cooperation. We believe that as meetings such as these become more widespread across the Kinki Region, they can serve as part of an integrated community care system. Through the formation of a number of alli...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Sugimoto T, Ogawa M, Soma M, Sakamoto K, Taniai A Tags: Yakugaku Zasshi Source Type: research

[Think about a Pharmacist/Pharmacy in the Insurance Pharmacy-Things to Consider in the Field].
Abstract About two years have passed since the formal establishment of the category "family pharmacist" in Japan's revision of dispensing fees. In the pharmacy vision for patients, many problems were raised among the category of "family pharmacists" or "family pharmacies". Furthermore, in the future restructuring of pharmacy practices, by 2025 all pharmacies are to serve as "family pharmacies", and by 2035 they will exercise their family pharmacy function in daily living areas. In order to demonstrate the "family function", home medical care and outreach type healt...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Omori M Tags: Yakugaku Zasshi Source Type: research

[The Pharmacy Combining Convenience Store with Care Consulting Services].
Abstract The primary pharmacy system and health support pharmacy system were established in 2016. However, local pharmacies need to get closer to the community. To this end, each pharmacy is making efforts to contribute locally. Here, we introduce various initiatives in our region. Akakabe Pharmacy has 66 stores in Osaka Prefecture, mainly in the northeastern part of Osaka, where the elderly population is growing. We are implementing a dominant strategy: cooperation with the city and administration is strong, and we hold many related events directed towards the public. For example, two thousand participants gather...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Kuriyama T, Shiromukai K, Masui R, Kitakoshi W, Matsuyama N Tags: Yakugaku Zasshi Source Type: research

[The Project to Extend Healthy Life Expectancy by Having Fun, in Collaboration with Kobe Women's University (KWU)].
Abstract We have conducted health promotion workshops in Kobe City, beginning in June 2016, to promote the view of pharmacies as community health centers that provide not only medicine but also offer support for maintaining and enhancing a person's health. To this end, we collaborated with Kobe Women's University (KWU). Our health promotion workshops included: 1. Activities of daily living (ADL) exercises led by a KWU professional; 2. Lectures on various diseases by dietitians and pharmacists; 3. Nutritional guidance from a dietitian; 4. Health counseling by a pharmacist; and 5. Measurements of bone density, vascu...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Sanda K, Itoi A, Shigefuku K, Yoshikawa Y, Tsuchiya K Tags: Yakugaku Zasshi Source Type: research

[Fostering Mixed-skill Pharmacists for Careers in Health Support Pharmacies-Education to Overcome the Barrier of Limited Occupational Expertise].
Abstract For becoming a talented pharmacist at a health support pharmacy, the practitioner must obtain ability in two significant skill sets: "Technical skill" and "Non-technical skill". Technical skills are that required for a pharmacist's specialty/expertise, such as a wide variety of specialized knowledge and techniques. Non-technical skills are those required for effective communication and cooperation with patients, as well as with professionals from multiple fields, and also leadership/problem-solving ability within a team. Therefore, technical skill and non-technical skill go hand-in-han...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Yamada M, Sakaguchi T, Tokuda K, Ouchi K, Sekine H, Murakami A, Takada N, Ijitsu T, Kogure K Tags: Yakugaku Zasshi Source Type: research

[Choosing Wisely and Shared Decision Making-An Expected Role for Pharmacists].
PMID: 30930385 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Yamamoto M, Terada T Tags: Yakugaku Zasshi Source Type: research

[Toward a "Choosing Wisely" Future in Medicine].
[Toward a "Choosing Wisely" Future in Medicine]. Yakugaku Zasshi. 2019;139(4):547-550 Authors: Kaji Y Abstract The "Choosing Wisely" campaign is an activity to promote conversations between patients and doctors about unnecessary examinations, treatments, or procedures. A "Top five list" published by a number of specialty societies consists of five evidence-based recommendations in their own fields. Choosing Wisely Japan was launched in 2016; the campaign soon became widespread among primary care physicians. To make wiser choices in prescriptions of any medicine, it is nec...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Kaji Y Tags: Yakugaku Zasshi Source Type: research

[Activities of Choosing Wisely and Role of Pharmacists].
Abstract Choosing Wisely (CW) is a pharmaceutical campaign activity that is spreading rapidly internationally. Briefly, it is an activity "aiming for appropriate medical care by reviewing the medical practice that is practiced despite lack of evidence from the viewpoint of evidence based medicine (EBM)". Here, healthcare workers and patients, through dialogue, are aiming to be able to carry out medical practices (examinations, treatment) that are scientifically validated, truly necessary, and have few side effects. In 2012, the American Institute of Internal Medicine listed five topics (Top Five Lists) a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Yamamoto M Tags: Yakugaku Zasshi Source Type: research

[The Role of Pharmacists in Antimicrobial Stewardship].
Abstract Antimicrobial resistance (AMR) has been declared a global public health emergency, necessitating the involvement of the whole of society to address this increasingly serious threat. AMR causes prolonged illness, greater risk of infection spread, increased morbidity, and higher mortality rates, which result in increased expenses to the government, healthcare services, and individuals. Inappropriate use of antimicrobials has been indicated as the primary cause for the global expansion of AMR. Under these circumstances, various countries have formulated suitable national action plans to curb AMR. In Japan, t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Muraki Y Tags: Yakugaku Zasshi Source Type: research

[Establishing Evidence for Appropriate Drug Use during Pregnancy and Lactation].
Abstract When considering the use of pharmaceutical drugs during pregnancy and lactation, two concerns must be weighed against each other: the potential deleterious effects on the fetus and the possibility that treatment necessary for the woman but risky for the fetus either cannot be administered or else the woman must give up the pregnancy or give up nursing. The main roadblock to weighing these two concerns is a lack of evidence about what drugs are harmful to the fetus. Establishing this evidence is important to implementing the "Choosing Wisely" policy. In 2005, Japan established the Japan Drug Info...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Nakajima K Tags: Yakugaku Zasshi Source Type: research

[Appropriate Use of Medicine and Polypharmacy in Older Patients].
Abstract In Japan, the population aged 65 years and older exceeds 28% of the total population. Since the birth rate is also declining, aging of the population is likely to continue. According to a patient survey conducted by the Ministry of Health, Labour and Welfare in 2014, the number of outpatients aged ≥65 years was higher by approximately 1.8 million since the previous survey in 2011. Drug therapy for the elderly is, thus, a matter of rapidly growing importance. The older generation has poorer physiological functions than younger adults. Therefore they are more likely to experience variable efficacy of dru...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Ooi K Tags: Yakugaku Zasshi Source Type: research

["Choosing Wisely" Improves Shared Decision Making].
["Choosing Wisely" Improves Shared Decision Making]. Yakugaku Zasshi. 2019;139(4):575-578 Authors: Kitazawa K Abstract "Choosing Wisely" is a campaign activity promoting awareness of the dangers of providing medical tests, drugs, and procedures that are not supported by firm scientific evidence and that may harm patients. The American Society of Health-System Pharmacists has released a recommendation on polypharmacy. Stakeholders such as patients, health professionals, hospital executives, industry, and mass media may all contribute to treatment decision making. The patient-centric...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Kitazawa K Tags: Yakugaku Zasshi Source Type: research

[Foldamer: Design, Conformation, and Function].
PMID: 30930392 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Oba M, Umezawa N, Demizu Y Tags: Yakugaku Zasshi Source Type: research

[Novel Helical Foldamers Based on the Conformational Properties of Aromatic Amides].
Abstract In this review, we focus on our recent work on the development of novel helical foldamers based on the cis conformational properties of aromatic amide bonds. First, we describe the conformational properties of N-alkylated pyrroleamides and their oligomers. The conformation of the amide bond on the pyrrole ring is altered by N-alkylation, and the ratio of the cis conformer is lower in N-methylated amides with an N-pyrrole ring compared with that in N-methylbenzanilide. Pyrrole-containing oligomers, in which benzene and pyrrole rings are linked alternately by amide bonds with chiral N-substituents, show sig...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Tanatani A Tags: Yakugaku Zasshi Source Type: research

[Aromatic Foldamers Recognizing Saccharides to Form Chiral Helices].
Abstract New meta-arylene ethynylene foldamers were developed by employing pyridine and phenol units. These demonstrated interesting properties related to the hydrogen-bonding behavior of the arylene units. Pyridine-acetylene-phenol foldamers showed improved saccharide recognition abilities compared with pyridine-acetylene foldamers with no phenol units. Solid-liquid extraction could be achieved due to the strong binding. Hydrocarbon stapling by alkene metathesis under templation was attempted, and the helical structure was efficiently stabilized. Phenol-acetylene oligomers spontaneously formed helical structures ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Abe H Tags: Yakugaku Zasshi Source Type: research

[Peptide Foldamers: Structural Control and Cell-penetrating Ability].
Abstract α,α-Disubstituted α-amino acids (dAAs), in which the α-hydrogen of the α-amino acid is replaced with an alkyl substituent, stabilize peptide secondary structures and have been utilized as a tool for building blocks of peptide foldamers. Peptides composed of acyclic dAAs with two bulky substituents equal to or larger than ethyl groups are more likely to form an extended planar conformation, whereas peptides with cyclic dAAs are more likely to adopt a helical structure. Based on these conformational properties of dAA-containing peptides, we developed a novel methodology using c...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Oba M Tags: Yakugaku Zasshi Source Type: research

[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism].
Abstract Diseases of the motor-conducting system that cause moving disability affect socio-economic activity as well as human dignity. Neurolathyrism, konzo, and amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC) have attracted researchers to study the pathology of motor neuron (MN) diseases such as ALS. I have been studying neurolathyrism, which is caused by overconsumption of a legume grass pea (Lathyrys sativus L.). Among people who consume the legume as a food staple, many developed life-long paraparesis in their legs. β-N-oxalyl-l-α,β- diaminopropionic (l-β-ODAP; BOAA),...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Kusama-Eguchi K Tags: Yakugaku Zasshi Source Type: research

[Interaction of Salmonella with Macrophages-Critical Roles of Salmonella SEp22, a Pathogenicity-related Protein, and Macrophage Reactive-Oxygen Intermediate Species (ROIs) on the Infection and Survival of Salmonella].
In this study, I found a novel pathogenicity-related protein of Salmonella, SEp22, an iron-chelating protein of MW 18.7 kDa, to cope with reactive-oxygen intermediates (ROIs) generated by activated macrophages pre-treated with lipopolysaccharides (LPS), one of the major components of Salmonella outer membrane. We also showed that Salmonella attacks macrophages by a novel mechanism through the induction of apoptosis with large amounts of LPS and protein synthesis inhibition, in addition to the well-known mechanisms of type-three secretion system (TTSS)-induced cell damage, including InvA, an attacking, virulent factor of Sa...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Amano F Tags: Yakugaku Zasshi Source Type: research

[Comparison of Pegfilgrastim and Filgrastim for the Primary Prophylactic Effect for Preventing Febrile Neutropenia in Patients Undergoing Rituximab with Dose-adjusted EPOCH Chemotherapy].
In this study, we retrospectively compared the efficacy of pegfilgrastim with that of filgrastim in patients receiving DA-EPOCH-R in Hiroshima University Hospital. Efficacy assessment was based on incidence of FN and serious neutropenia (neutrophil count
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Kataoka T, Sakurashita H, Taogoshi T, Nishigakiuchi R, Murase T, Izumitani S, Saeki Y, Matsuo H Tags: Yakugaku Zasshi Source Type: research

[Prediction of Wettability and Adhesion of Lotion to Skin Based on the OWRK Method].
In this study, we propose a new technique for evaluating wetting and adhesion of lotions to skin using surface tension measurements, contact angle measurements and calculations based on the Owens-Wendt-Rabel-Kaelble (OWRK) method. Three prescription lotions (Napageln® Lotion 3%, Sumilu® Lotion 3% and Felbinac Lotion 3% 「Rakool」) and two over-the-counter lotions (Feitas® Lotion and Salomethyl® FB Lotion α) were used. Based on the dispersive and polar components of the surface free energy of Yucatan micro pig (YMP) skin, isograms of contact angle (wetting envelope) and adhesion work of the YMP ski...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Hashizaki K, Sunaga K, Oda Y, Bashuda M, Imai M, Goto Y, Taguchi H, Saito Y, Fujii M Tags: Yakugaku Zasshi Source Type: research

[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B].
Abstract We herein present the case of a 66-year-old Japanese man with Fanconi's syndrome. He had been receiving adefovir dipivoxil (ADV) for the treatment of entecavir (ETV)-resistant chronic hepatitis B (CHB) for four years in his 8-year treatment of hepatocellular carcinoma (HCC), but was referred to our hospital after increased levels of bone pain in his ribs, knees, and ankles. Renal dysfunction, hypophosphatemia, and increased levels of bone alkaline phosphatase were found by a hematology test after admission for treatment of HCC. Radiography and 99m Tc-labeled hydroxymethylene diphosphonate (HMDP) scintigra...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Makita T, Kanzaki H, Onishi H, Ikeda A, Takaki A, Wada N, Takeuchi Y, Yasunaka T, Ikeda F, Shiraha H, Tanaka Y, Nishihara S, Murakawa K, Kitamura Y, Okada H, Sendo T Tags: Yakugaku Zasshi Source Type: research

[Effectiveness of Steroid Rotation in a Japanese Patient with Hiccups Caused by Dexamethasone: a Case Report].
We report a case of the effectiveness of steroid rotation in a Japanese patient with hiccups caused by dexamethasone for antiemetic chemotherapy. A 74-year-old man was diagnosed as having stage IV gastric cancer. Chemotherapy was initiated using S-1 (80 mg/d on Days 1-21) and cisplatin (80 mg on Day 8), with dexamethasone (8 mg/d on Day 8 intravenously and on Days 9-11 orally) as antiemetic. Severe hiccups developed on Day 10 and resolved on Day 11 by the 1st cycle of chemotherapy. Subcutaneous injection of atropine by the 5th cycle and ingestion of Syakuyakukanzouto (Glycyrrhiza extract) by the 6th cycle did not effective...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 2, 2019 Category: Drugs & Pharmacology Authors: Hosokawa H, Shimoda H, Ishii T Tags: Yakugaku Zasshi Source Type: research

[Study of Formulation Development Based on the Pharmacokinetic Properties of Functional Food Components].
In this report, as examples, we describe the enhancement of the absorption of coenzyme Q10 (CoQ10) and lutein. To improve the absorption of CoQ10, we focused on the component of emulsion. We found that a higher plasma concentration of CoQ10 could be obtained by creating an emulsion containing a surfactant with a higher hydrophile-lipophile balance (HLB) value. For the improvement of lutein absorption, we prepared a solid dispersion and self-emulsifying drug delivery system. It was shown that the plasma concentrations of lutein in these two formulation groups were increased compared with that in the powder group. The absorp...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Sato Y Tags: Yakugaku Zasshi Source Type: research

[Fascination of Cyanobacterium Aphanothece sacrum and Sacran as Functional Materials].
PMID: 30828010 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Arima H, Kaneko T Tags: Yakugaku Zasshi Source Type: research

[Optical Second-harmonic Observation of Stimulated Sacran Aggregates].
Abstract Second-order nonlinear optical images of aggregates of the ampholytic megamolecular polysaccharide sacran under various stimuli were observed by optical second-harmonic generation (SHG) microscopy. SHG intensity microspots of several tens of micrometers in size are seen for sacran cotton-like lumps and fibers and they have very clear incident polarization dependence. In these microspots, the sacran molecules are oriented in concentric multilayers. We also observed SHG images of sacran prepared in a needle-ring electrode with applied voltage, where SHG was enhanced near the negatively biased needle electro...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Mizutani G, Zhao Y, Khuat HTT, Okajima M, Kaneko T Tags: Yakugaku Zasshi Source Type: research

[Industrial and Medical Material Applications of a Mega-polysaccharide Derived from Cyanobacteria].
This article introduces various applications of sacran in the industrial and medical fields. PMID: 30828012 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Okajima M, Kaneko T Tags: Yakugaku Zasshi Source Type: research

[Function of Sacran as an Artificial Skin Barrier and the Development of Skincare Products].
Abstract Sacran, a large molecular-weight polysaccharide isolated from algae, is composed of 11 types of saccharides, including sulfate and carboxylic acid groups. Because of its unique structure, sacran can form a gel-like sheet in the presence of polyols such as 1,3-butanediol. In addition, those sacran gel-like sheets prevent the evaporation of water and the penetration of chemicals. The results of our previous study suggested that sacran can work as an artificial barrier against external stimuli such as air pollutants which increase the stress on humans. Topically applied sacran was localized at the surface of...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Masaki H, Doi M Tags: Yakugaku Zasshi Source Type: research

[Preventive Effects of Aphanothece sacrum on Diabetic Cataracts].
In this study, the inhibitory effects of Asa on the pathogenesis of diabetic cataracts were evaluated. Furthermore, the inhibitory effects of Asa on the formation of Nε-(carboxymethyl) lysine (CML), an oxidation-dependent advanced glycation end-product, were also measured. After 3-month administration, the CML contents in the lens were measured by liquid chromatography tandem mass spectrometry using an internal standard of CML or lysine. Asa significantly inhibited the progression of cataractogenesis and accumulation of CML in diabetic lens compared with the normal diet group. These results suggested that daily int...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Sugawa H, Matsuda S, Shirakawa JI, Kabata K, Nagai R Tags: Yakugaku Zasshi Source Type: research

[Potential Use of Sacran for Dermal and Oral Preparations].
Abstract Sacran, a new polysaccharide isolated from cyanobacterium Aphanothece sacrum (Sur.) Okada, is known to have potential as an active pharmaceutical ingredient (API) for the treatment of atopic dermatitis, various types of dermatitis, skin wound, hemorrhoids and corneal epithelium disorder. In the present studies, the effects of sacran on skin injury and skin pain induced by stratum corneum tape-stripping and gastric ulcer induced by indomethacin, a non-steroidal anti-inflammatory drug (NSAID), and hydrochloride/ethanol (HCl/EtOH) in mice were investigated. Sacran solution 0.05% (w/v) showed greater reductio...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Arima H, Motoyama K, Higashi T Tags: Yakugaku Zasshi Source Type: research

[The Report: Promotion of Social Contributions of Research on Clinical Pharmacy and Pharmaceutical Sciences].
This report was prepared based on the analysis of current situation of the four-year doctoral course in the graduate school of pharmacy and the contents of the symposium of 137th annual meeting of the Pharmaceutical Society of Japan (PSJ), "Pharmaceutical Sciences in the Future: The Bridge Linking between Basic and Clinical Research". The goal of the 4-year doctoral program is to nurture the pharmacist-scientist who has both researcher mind and professionalism as a clinical pharmacist. Research on clinical pharmacy and pharmaceutical sciences is a core research area of the 4-year doctoral course, therefore its pr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Mochizuki M Tags: Yakugaku Zasshi Source Type: research

[Summary of a Report from the Science Council of Japan].
Abstract The Subcommittee of Clinical Pharmacy and Pharmaceutical Sciences, Committee of Pharmaceutical Sciences, Science Council of Japan, released the report "Promotion of Social Contributions of Research on Clinical Pharmacy and Pharmaceutical Sciences" in September 2017, after analyzing the current status of the doctoral course in the 4-year system and extensive discussion. The analysis demonstrated that most of the themes of the doctoral course were related to research. However, most of the students in the general selection were involved in basic research, while the students in the adult selection w...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Takakura Y Tags: Yakugaku Zasshi Source Type: research

[The Role of the Pharmaceutical Society of Japan in Advancing of Clinical Pharmacy Research].
Abstract Since the start of the 6-year program in pharmacy education, outcome-based education has progressed, and students' experience of onsite pharmacy practice has increased their awareness of their roles as pharmacists. This progress has been confirmed by student reports submitted at the end of onsite practice. In addition, the results of undergraduate students' graduation research as well as those of clinical research carried out in graduate schools are presented at the annual meetings of the Pharmaceutical Society of Japan (PSJ) and its local branches. Research activity is also promoted by the various divisi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Oku N Tags: Yakugaku Zasshi Source Type: research

[Promotion of Pharmaceutical Care and Sciences: Focus of the Japanese Society of Pharmaceutical Health Care and Sciences].
Abstract The 6-year education system for pharmacists was introduced in Japanese schools of pharmacy in 2006, after which a 4-year doctoral course system was established for advancing clinical pharmaceutical research. The roles of hospital pharmacists and community pharmacists have been expanded from drug dispensing to patient care. Clinical pharmacists practice patient care daily using evidence-based medicine and shared decision making. Clinical pharmacists also carry out research proactively for resolving clinical questions encountered in practice. The Japanese Society of Pharmaceutical Health Care and Sciences (...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Sasaki H Tags: Yakugaku Zasshi Source Type: research

[Introducing the Academy of Pharmaceutical Science and Technology, Japan].
Abstract The Academy of Pharmaceutical Science and Technology, Japan (APSTJ) has contributed to advances in pharmaceutical sciences and progress in formulation technologies. The APSTJ has some 2000 individual members including pharmacists, researchers, technologists, and representatives of regulatory authorities. Remarkably, more than 800 individual members are from the industry. The APSTJ holds an annual meeting and several conferences or seminars on pharmaceutical technologies and skills. It has also set up 13 focus groups (FGs), including some working energetically on medical pharmacy research. For example, the...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Imai T Tags: Yakugaku Zasshi Source Type: research

[Message from the President of the Japanese Society for the Study of Xenobiotics].
Abstract The Japanese Society for the Study of Xenobiotics has focused on drug development and clinical pharmacotherapy by applying cutting-edge technology and reviewing drugs. One specific area of focus has been the reverse-translational approach. This approach uses data from the investigation of clinical problems and from the detailed revisiting of preclinical studies to discover new pharmacotherapies and new methods to prevent drug-induced side effects. In 2017, the U.S. Food and Drug Administration restricted the use of prescription codeine cough-and-cold medicines in children. This decision was based on conce...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Yamazaki H Tags: Yakugaku Zasshi Source Type: research

[Development of Novel Functional Formulations Based on Pharmaceutical Technologies].
Abstract After 32 years as a researcher in a pharmaceutical company, the author has served as a professor in the Development of Pharmaceutical Engineering and Drug Delivery Science at University of Shizuoka for the past 11 years. The research I was involved in can be categorized into four main items. First, the crystal transformation of clarithromycin (CAM) was focused on to develop the CAM high-loaded sustained release and gastro-floating formulations. Furthermore, the stabilization mechanism of CAM in the gastro-intestinal tract was clarified to elucidate gel formation under conditions of low pH. Second, the dev...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Itai S Tags: Yakugaku Zasshi Source Type: research

[Verification of Pharmacokinetic Approaches in Prior Drug Development].
Abstract In this review, 9 compounds with insufficient absorption characteristics, safety or efficacy were selected from among the compounds for which the author was in charge of development between 2000 and 2005, in order to evaluate the pharmacokinetic (PK) approaches used to develop these compounds. Optimization of the PK characteristics of a compound at the early stage of chemical design was found to be the most important factor for successful development. For example, (i) selecting class I or II drugs in the biopharmaceutical classification system, while avoiding efflux transporters, and introducing an approp...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Iga K Tags: Yakugaku Zasshi Source Type: research

[Analysis of the Risk Factors Associated with Minor Bleeding in Patients with Venous Thromboembolism during Treatment with Direct Oral Anticoagulants].
Abstract Direct oral anticoagulants (DOACs) are safe and efficacious when compared to warfarin for patients with venous thromboembolism (VTE). However, bleeding is a major side effect of anticoagulant therapy in VTE patients. Discontinuation of the DOACs associated to adverse events such as bleeding. The HAS-BLED score predicts warfarin-associated hemorrhage. However, little is known about risk factors for DOAC-associated minor bleeding in VTE patients. We aimed to identify risk factors for minor bleeding in VTE patients that were treated with edoxaban, rivaroxaban, or apixaban. We retrospectively evaluated the da...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Sunaga T, Shimizu T, Nakamura S, Takahashi N, Higashino M, Matsui M, Hozumi T, Ebato M, Suzuki H, Kogo M, Watanabe T, Sasaki T Tags: Yakugaku Zasshi Source Type: research

[Adverse Events after the Introduction of Quadrivalent Influenza Vaccine in Comparison with AH1pdm Vaccine (2009) in Japan].
This study examined the safety of IIV4 in comparison with the AH1pdm monovalent vaccine used for novel influenza in 2009. Questionnaire surveillance associated with adverse events (AEs) was conducted at Chiba University Hospital, Japan. After being vaccinated, all health care workers (HCWs) were given a daily AEs check sheet on which they recorded solicited events, the same surveillance program used after AH1pdm vaccination in 2009. The frequency of injection site AEs with IIV4 was significantly higher than with the monovalent vaccine, but there was no significant difference with systemic AEs. Injection site and systemic A...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Yamazaki S, Fujiwara M, Inoue C, Watanabe M, Takayanagi S, Taniguchi T, Watanabe A, Ishiwada N, Igari H Tags: Yakugaku Zasshi Source Type: research

[A Survey of Health Food Use and Patient Satisfaction among Patients Undergoing Cancer Pharmacotherapy].
This study aimed to clarify the situation of use of health foods by patients and the level of satisfaction of patients in order to make use of information on cases where patients undergoing cancer medication therapy use health foods. Between May 7, 2018 and June 29, 2018, we conducted a questionnaire survey of patients with progressive cancer who were undergoing cancer chemotherapy at Ogaki Municipal Hospital. In addition, we conducted a multivariate analysis of patients who were using health foods and those who were not. The questionnaire items included the objectives of use, product effectiveness and satisfaction, and QO...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Kawaguchi M, Kimura M, Usami E, Kawachi S, Go M, Ikeda Y, Yoshimura T Tags: Yakugaku Zasshi Source Type: research

[Effectiveness of a Low-dose Corticosteroid in a Patient with Polymyalgia Rheumatica Associated with Nivolumab Treatment].
We report a case of an NSCLC patient who developed PMR during treatment with nivolumab and received corticosteroids. A 74-year-old man without a history of autoimmune diseases received nivolumab at a dosage of 3 mg/kg once every 2 weeks for the treatment of stage IIIB squamous cell carcinoma. After 12 cycles of nivolumab treatment, he developed grade 3 muscle pain and arthralgia, requiring hospitalization and discontinuation of nivolumab. A bone scintigraphy revealed no bone metastasis. Serological tests showed that although creatine phosphokinase did not increase, C-reactive protein and the erythrocyte sedimentation rate ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 6, 2019 Category: Drugs & Pharmacology Authors: Imai Y, Tanaka M, Fujii R, Uchitani K, Okazaki K Tags: Yakugaku Zasshi Source Type: research

[Effect of Statins on Glycemic Status and Plasma Adiponectin Concentrations in Patients with Type 2 Diabetes Mellitus and Hypercholesterolemia].
Abstract It is reported that statins have inconsistent effects on glycemic status and adiponectin concentrations in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate the effect of statins on these variables in patients with T2DM and hypercholesterolemia. A control group comprising 24 patients with T2DM but without hypercholesterolemia was observed for more than 12 weeks, while 24 patients with T2DM and hypercholesterolemia were treated with statins for the same period (statin group). The percentage changes in the glycemic status (blood glucose and glycated hemoglobin [HbA1c]), and levels of pl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 15, 2019 Category: Drugs & Pharmacology Authors: Hori E, Kikuchi C, Imaeda K, Okayama N, Suzuki T, Matsunaga T Tags: Yakugaku Zasshi Source Type: research

[Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry].
PMID: 30713222 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Iohara D, Higashi T Tags: Yakugaku Zasshi Source Type: research

[Intracellularly Degradable Polyrotaxanes for Therapeutic Applications].
Abstract Recently, the application of β-cyclodextrins (β-CDs) as therapeutic agents has received considerable attention. β-CDs have been reported to have therapeutic effects on various diseases, such as Niemann-Pick type C (NPC) disease, a family of lysosomal storage disorders characterized by the lysosomal accumulation of cholesterol. To further improve the therapeutic efficacy of β-CDs, the use of β-CD-threaded polyrotaxanes (PRXs) has been proposed as a carrier of β-CDs for NPC disease. PRXs are supramolecular polymers composed of many CDs threaded onto a linear polymer chain and c...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Tamura A Tags: Yakugaku Zasshi Source Type: research

[Design Features in the Molecular-level Development of Solid Pharmaceutical Formulations Based on Supramolecular Structures].
Abstract We focused on the crystal structure of cyclodextrin (CD) to develop new solid CD complexes. There are two large spaces in the columnar structure of CD crystals: one inside a CD cavity and another between CD columns. New solid CD complexes can be designed by incorporating guest drugs between the CD columns. We succeeded in preparing a solid drug/[polyethylene glycol (PEG)/γ-CD-polypseudoraxane (PPRX)] complex by a sealed-heating method via the gas phase. A drug/(PEG/γ-CD-PPRX) complex has a structure in which PEGs are included in a γ-CD cavity, and guest drugs are incorporated between the...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Higashi K, Ueda K, Moribe K Tags: Yakugaku Zasshi Source Type: research

[Functionalization of Cyclodextrin Derivatives to Create Supramolecular Pharmaceutical Materials].
Abstract Molecular recognition is useful in creating functional supramolecular materials. Non-covalent bond formations, such as host-guest interactions, hydrogen bonding, and electrostatic interaction, are effective tools for introducing various functions and properties into materials. This review focuses on such macroscopic functions as selective molecular adhesion, self-healing, toughness, and the actuation of supramolecular polymeric materials-materials which have potential in pharmaceutical development. These functions have been achieved using reversible bonding between cyclodextrins (CDs; cyclic host molecule...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Osaki M Tags: Yakugaku Zasshi Source Type: research

[Supramolecular Pharmaceutical Sciences: A Novel Concept for Future Pharmaceutical Sciences].
Abstract Supramolecular chemistry is a useful and important domain for understanding pharmaceutical sciences, since various physiological reactions (e.g., protein association) and drug activities (e.g., the substrate/receptor reaction) are based on supramolecular chemistry. Biological components, such as DNA and cells, are also supermolecules. However, supramolecular chemistry to date has not been a major domain in the field of pharmaceutical study. In this article, we propose a new concept in pharmaceutical sciences termed "supramolecular pharmaceutical sciences" which combines pharmaceutical sciences a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Higashi T, Motoyama K, Arima H Tags: Yakugaku Zasshi Source Type: research

[Challenges of Young Chemists to Be Global].
PMID: 30713227 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2019 Category: Drugs & Pharmacology Authors: Komatsu T, Itoh Y Tags: Yakugaku Zasshi Source Type: research