[Effect of Digital Labels on Electronic Medical Records for Reducing the Use of Benzodiazepine Receptor Agonists].
This study aimed to verify the effectiveness of reducing the use of BZDs via the implementation of digital labels. Patients in the surgical ward were retrospectively assessed for changes in medication orders and prescription ratios of BZDs before and after the implementation of digital labels. The ratio of the number of digital labels implemented to the number of confirmations of medication orders and prescriptions of BZDs was 15.0% at the start of implementation; however, the ratio gradually and significantly decreased to 3.6%. The medication order ratio of BZDs was 52.2% before the implementation of digital labels; howev...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Shin K, Kobayashi D, Kawashiri T, Ikari K, Mitsuyasu H, Murakami T, Tsutsumi K, Kanazawa Y, Kamimura H, Shimazoe T Tags: Yakugaku Zasshi Source Type: research

[Chronic Effects on Kidney Function by "Triple Whammy" (Combination of Renin and Angiotensin Type Inhibitor, Diuretic Drug and Nonsteroidal Anti-inflammatory Drug)].
In this study, we investigated the chronic effects of the "Triple Whammy" on kidney function. There were 203 outpatients who were prescribed this combination in our hospital for 5 years. We excluded patients who could also confirm the combination in the previous year and patients for whom laboratory data were unavailable, thus, leaving a target patient group of 95 patients. The average estimated glomerular filtration rate (eGFR) decreased significantly from 62.6 to 58.9 mL/min/1.73 m2 immediately after administering the combination (p
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Kunitsu Y, Isono T, Hira D, Terada T Tags: Yakugaku Zasshi Source Type: research

[Attitude Survey Data on Interaction between Dietary Supplements and Medicines].
In conclusion, the understanding of the interaction between health foods and medication among consumers is still limited and most of them do not consult with specialized physicians. It has been revealed that efforts to expanding the consumers understanding on the risk of interaction between supplements and medicines are necessary. It was suggested that the "Database for guiding the interaction between medicines and health foods" could be a useful tool for providing this type of information. PMID: 31685743 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Ikuta T, Miura T, Shinozuka K Tags: Yakugaku Zasshi Source Type: research

[Simultaneous Quantitative Analysis of Berberine and Other Alkaloids in Powdered Phellodendron Bark].
In this study, we compared the contents of the three constituents obtained from the extracts of Japanese and Chinese phellodendron bark and found remarkable difference. PMID: 31685744 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Kamimura S, Nishihara M, Osumi Y, Shiota H Tags: Yakugaku Zasshi Source Type: research

[Risk of Euglycemic Diabetic Ketoacidosis Due to Low-carbohydrate Diet While Taking Empagliflozin: a Case Report].
Abstract Empagliflozin reduces blood glucose levels independently of insulin secretion by reducing glucose reabsorption in the proximal renal tubules through inhibition of sodium-glucose cotransporter 2 (SGLT2). Because SGLT2 inhibitors have a different mechanism of action to conventional antidiabetic drugs, recommendations have been issued about the management of specific side effect such as ketoacidosis, urinary tract infection, and genital infection. There have been some reports of SGLT2 inhibitor-associated euglycemic diabetic ketoacidosis (euDKA), but there have been few reports about euDKA in patients with t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 8, 2019 Category: Drugs & Pharmacology Authors: Yamamoto M, Ide N, Kitajima S, Obayashi M, Asada K, Matsushima S, Ito M Tags: Yakugaku Zasshi Source Type: research

[The Analgesic Effect of Aspirin on Inflammatory Pain in Rats is Affected by Pain Intensity and Administration Timing].
This study aimed to elucidate whether the analgesic effect of NSAIDs changes depending on the situation in which they are taken and we focused on the NSAID, aspirin (ASP). In a rat model of brewer's yeast-induced inflammation, pain caused by 20% w/v brewer's yeast-treatment was defined as "strong pain" and that caused by 2.5% w/v was defined as "weak pain." The analgesic effect of ASP (low-dose; 44 mg/kg or high-dose; 66 mg/kg) against strong pain was dose-dependent, but that against weak pain was the same. Furthermore, we defined drug administration after 3 h of brewer's yeast-treatment as "late a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 25, 2019 Category: Drugs & Pharmacology Authors: Kitahara M, Seki K, Midorikawa T, Arita J, Uchiyama A Tags: Yakugaku Zasshi Source Type: research

[Examination of extraction conditions of chlorogenic acid and its content in domestic Phellodendron amurense leaves].
Abstract Phellodendron amurense is a broad-leaved tree; its outer bark and cork layers are removed and used as a crude medicinal agent known as Phellodendri Cortex. These trees are cultivated for approximately 15 to 20 years, harvested by felling, and processed by separating the outer and inner bark. Conventionally, parts other than the inner bark (i.e., fruit, leaves, and heartwood) remain unused. However, the revenue earned from by-products could contribute to continued cultivation of Phellodendron amurense. Herein, we examined the extraction condition and investigated the content of chlorogenic acid in the leav...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 15, 2019 Category: Drugs & Pharmacology Authors: Nishihara M, Osumi Y, Tanaka H Tags: Yakugaku Zasshi Source Type: research

[Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].
Abstract The liver is a major organ responsible for maintaining the body's homeostasis and xenobiotic metabolism. Liver transplantation is essential for the alleviation of many severe liver diseases. However, there are many patients who cannot receive liver transplants because of donor shortage. Therefore development of effective therapeutic drugs that can replace the need for liver transplantation is desired. To this end, model cells that faithfully reproduce hepatic functions are essential. It is expected that human induced pluripotent stem cell (iPS)-derived hepatocyte-like cells, which faithfully reproduce hep...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Takayama K Tags: Yakugaku Zasshi Source Type: research

[Clinical Pharmacometrics for Rational Drug Treatment].
In conclusion, pharmacometrics is a useful methodology for individualized and optimized drug therapy. PMID: 31582605 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Yano I Tags: Yakugaku Zasshi Source Type: research

[Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles].
Abstract Reactive oxygen species (ROS) are highly reactive molecules generated during mitochondrial respiration and under various environmental stresses, and cause damage to DNA, proteins, and lipids, which is linked to a wide variety of pathologies. However, recent studies have revealed the physiological importance of ROS as signaling molecules, which play crucial roles in the maintenance of cellular functions and homeostasis. According to the extent and duration of ROS generation, ROS-mediated oxidation-reduction (redox) signaling (ROS signaling) is tightly regulated by various molecules and post-translational m...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Hirata Y Tags: Yakugaku Zasshi Source Type: research

[C-H Functionalization by Transition-metal-catalyst or in Situ Generated Base].
Abstract Direct functionalization of the C-H bond is a highly attractive method because it does not require any pre-functionalized starting materials. Therefore this method can be adopted to attain the atom- and step-economic synthesis of organic compounds. We recently developed novel C-H functionalization reactions using two strategies. The first strategy is transition-metal catalyzed C-H functionalization, which comprises the copper-catalyzed oxidative C(sp3)-H functionalization of 2-alkyl-N-arylbenzamides for the synthesis of N-aryl-isoindolinones. This method can be applied to various substituted substrates an...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Nozawa-Kumada K Tags: Yakugaku Zasshi Source Type: research

[Development of Stratified and Personalized Medicine Based on Pharmacogenomic and Pharmacokinetic Analyses].
In this study, we elucidated the effect of CYP4F2 polymorphisms associated with vitamin K metabolism by measuring the blood concentrations of warfarin and vitamin K. Then, to develop precision medicine for asthma and chronic obstructive pulmonary disease (COPD), we analyzed not only clinical symptoms but also pathological biomarkers and genes associated with inflammation. The findings may contribute toward better understanding of the pathological conditions of asthma, COPD, and asthma-COPD overlap. PMID: 31582608 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Hirai K Tags: Yakugaku Zasshi Source Type: research

[Construction of All-cis-substituted Cyclopropane and Total Synthesis of Avenaol].
Abstract The first total synthesis of avenaol was achieved using a new robust strategy involving all-cis-substituted cyclopropane formation via an alkylidene cyclopropane. The keys to success for the total synthesis were (i) Rh-catalyzed intramolecular cyclopropanation of an allene; (ii) Ir-catalyzed stereoselective double-bond isomerization to form an all-cis cyclopropane; and (iii) differentiation of two hydroxymethyl groups via regioselective cyclization and oxidation of tetrahydropyran based on the reactivity of cyclopropyl group. This strategy effectively avoids cyclopropane ring opening and undesired formati...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Yasui M Tags: Yakugaku Zasshi Source Type: research

[PDCA Cycle for the Development of Clinical Formulation Thinking in Actual Example].
PMID: 31582610 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Hanawa T, Momo K Tags: Yakugaku Zasshi Source Type: research

[Clinical Preparations: Status Quo and Challenges in the Future].
Abstract Dispensing clinical preparations requires the professional ability of pharmacists as specialists who understand the physicochemical properties of drugs. Clinical preparations contribute to the support of drug therapy and to commercialization by pharmaceutical companies. The Japanese Society of Hospital Pharmacists published the Guidelines on Hospital Preparations and Use in 2012. Those guidelines were designed to improve the safety and utility of hospital preparations, indicate the standard procedures for treatment in hospitals, and show how to ensure the quality of hospital preparations. The expiration d...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Kawata K, Ozawa C, Shohji T, Terada K, Suzuki M Tags: Yakugaku Zasshi Source Type: research

[Development of Hospital Formulations Based on Medical Need].
In this study, we prepared and evaluated a mouthwash for stomatitis taking into consideration the solubilization of RB. RB nanoparticles were prepared by the wet-milling technique using various forms of hydroxypropyl cellulose (HPC-L, -SL, and -SSL) and sodium lauryl sulfate (SLS). RB nanoparticles sized between 126.6 and 286.8 nm were obtained under various conditions. From the results of zeta potential measurement and evaluation of their dispersibility, it appeared that the prepared nanosuspensions were stable. Furthermore, adhesion of the nanoparticles to the mucous membrane in the oral cavity was evaluated using quartz...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Kawano Y, Hanawa T Tags: Yakugaku Zasshi Source Type: research

[Development of a Breathable Protective Ointment for Moisture-associated Skin Damage].
Abstract In this symposium, we present a novel breathable protective ointment (BPO) formulation developed at the University of Shizuoka for the prevention of moisture-associated skin damage (MASD) intended for use in healthcare settings. MASD occurs when moisture is in constant contact with the skin for prolonged periods of time, causing degradation of the skin barrier. Exposure to physical or chemical stimuli in addition to moisture may lead to different types of moisture-associated dermatitis such as incontinence-associated or periwound dermatitis. Another type of moisture-associated dermatitis, diaper dermatiti...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Miyazaki Y, Asano M, Uchino T, Kagawa Y Tags: Yakugaku Zasshi Source Type: research

[Examples of Clinical Formulation Design at a University and Response to Clinical Need].
Abstract In the healthcare setting, the handling of clinical preparations is essential for the development of tailor-made pharmaceutical agents. However, during the design and development of new clinical formulations, pharmacists may encounter various questions and problems related to handling the formulations, such as a lack of knowledge of and experience in prescription design. In addition, if pharmacists require assistance to solve problems, it is rare to find a person with sufficient knowledge of and experience with the formulation in their facilities, and there are few connections among facilities; therefore,...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Yonemochi E Tags: Yakugaku Zasshi Source Type: research

[Translational Research Focused on Hospital-prepared Drugs in Japan: Developing and Accessing an Approach Using an Evidence Database].
In this study, we show our recent approach to developing hospital preparations into commercially available drugs. Our first endpoint was to start phase 2 clinical trials of hospital-prepared drugs. The second endpoint was to determine whether the drugs could continue to phase 3 trials. We have developed an evidence database on 107 hospital-prepared drugs by performing a literature survey on each drug for references to the words "stability", "efficacy", and "safety". If evidence is lacking, in vitro study results are compiled in the database, which will be needed when initiating clinical trials...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Momo K, Kanezaki Y, Kawano Y, Hanawa T Tags: Yakugaku Zasshi Source Type: research

[The Current State and Future Prospects of Population Pharmacokinetic Research in Post-marketing Clinical Studies in Japan].
Abstract Population pharmacokinetics (PPK) is a useful approach to the evaluation of drug pharmacokinetics in patients and is a widely used method for the evaluation of pharmacokinetics in clinical trials. PPK uses a statistical model to calculate population parameters, their variance, and covariates from sparse and unbalanced data in a large target population. Population parameters can subsequently be used to establish individual prescribing regimens for specific patients. Post-marketing clinical studies using PPK analysis have been reported by medical and academic institutions in order to complement the poor pha...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Watanabe-Uchida M, Watanabe T, Narukawa M Tags: Yakugaku Zasshi Source Type: research

[Pharmacological Effects of Yokukansankachimpihange on Urinary Catecholamine in Restraint-stressed Mice].
Abstract Herbal medicines, acupuncture and moxibustion are often used for unidentified complaints. It is well known that catecholamine secreted by the sympatho-adrenal medullary system primarily functions to increase cardiac output and raise glucose levels in the blood during acute stress. In the present study, the effects of yokukansankachimpihange (YKSKCH, a Kampo medicine) on urinary catecholamine in mice that were repeatedly stressed by restraining were examined. Restraint stress (240 min/d×3 d×3 cycles, daytime: 12:00-16:00) induced a marked increase in noradrenaline (NA) and adrenaline (A) levels...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Michihara S, Han LK, Fujita N, Shibahara N, Takahashi R Tags: Yakugaku Zasshi Source Type: research

[Effects of Renal Function Evaluation with or without Serum Creatinine Adjustment on Cisplatin/Fluorouracil Therapy for Cervical Cancer].
Abstract The dosage of cisplatin is adjusted according to creatinine clearance (Ccr) estimated by the Cockcroft-Gault formula, which is commonly used as a marker for renal function. It is known that different serum creatinine (Scr) levels are reported depending on the analytical methods utilized such as the Scr level by the enzyme method being lower than that by the Jaffe method. Although the enzyme method is used in Japan, most drug dosages, including cisplatin, are adjusted according to the estimated Ccr using the Jaffe method-based Scr level. The purpose of this study was to investigate whether assessment of re...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Takagi M, Sagara A, Ishizawa A, Ito A, Miyazaki M, Senzaki K, Nagai T, Yamada K Tags: Yakugaku Zasshi Source Type: research

[Systematic Review of Case Reports on the Adverse Events Due to Health Food Intake by Cancer Patients].
Abstract Cancer patients use health foods (HFs) as complementary and alternative medicine, although the details of their adverse events (AEs) are unclear. We searched three databases [PubMed, "Igaku Chuo Zasshi", and Information System on Safety and Effectiveness for Health Foods website (https://hfnet.nibiohn.go.jp/)] for case reports on AEs related to HF intake in cancer patients published before October 2018. Of the matched reports, 76 studies and 92 patients (31 in Japan, 61 overseas) that met the selection criteria were included in this review. Thus, the severity of AEs and outcomes were not related...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Kojima A, Sato Y, Nishijima C, Umegaki K, Chiba T Tags: Yakugaku Zasshi Source Type: research

[Suggestion of Approached Method and the Personal Prescription Notebook Proposed for Pharmacotherapeutic Management of Patients with a Memory Disorder].
Abstract Patients with cognitive dysfunction caused by dysmnesia face difficulties in memorizing and learning general concepts; therefore, they encounter trouble in taking medications. Recently, a prescription notebook has been shown to be useful for patients receiving pharmacotherapy; however, it is not yet clear whether a common prescription notebook is useful for patients with a memory disorder. In our study, using a questionnaire for 61 patients, we first determined the benefits of and improvement in the drug administration guidance provided by a pharmacist to patients with a memory disorder compared with thos...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Goto-Torii A, Toyoyoshi Y, Yoshikawa M, Yasuda K, Hino T, Hayashi T Tags: Yakugaku Zasshi Source Type: research

[Development of an Immune Regulation Technology Targeting the Skin and Promotion of the Practical Applications of Transcutaneous Vaccination/Immunotherapy].
Abstract In the premise of vaccination and allergen-specific immunotherapy, transcutaneous formulations have an advantage over conventional subcutaneous injections in terms of convenience, simplicity of delivery, and painless administration into the skin. Additionally, since transcutaneous formulations can be rendered cold-chain free, they do not require expert handling during transportation, storage, and stockpiling, which enables reductions in costs and distribution to distant areas. Furthermore, transcutaneous formulations are effective for improving adherence in children with phobias toward injection needles a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Okada N Tags: Yakugaku Zasshi Source Type: research

[Regulation of Extracellular Redox Homeostasis in Tumor Microenvironment].
Abstract Excessive generation of reactive oxygen species (ROS) has been implicated in the progression of tumors. Superoxide dismutase 3 (SOD3) is a copper-containing secretory antioxidative enzyme that plays a critical role in redox homeostasis, particularly in extracellular spaces. Considerable evidence suggests that SOD3 protein expression is significantly decreased or lost in several tumor tissues, and this loss results in tumor metastasis. On the other hand, epigenetic disturbances, including DNA hyper-/hypomethylation, histone de/acetylation, and histone de/methylation, may be involved in tumorigenesis and th...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kamiya T Tags: Yakugaku Zasshi Source Type: research

[The Front Line of the NAFLD/NASH Study Reported from the Pharmaceutical Field-Feedback from Basic Research to Medical Treatment and Pharmacist Activity].
PMID: 31474629 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Tokuyama S, Ih Kim K Tags: Yakugaku Zasshi Source Type: research

[Overview of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis Management].
Abstract The number of patients with chronic liver diseases is expected to decline due to progress in antivirus therapy, including direct-acting antivirals for hepatitis C and nucleot(s)ide analogues for hepatitis B. On the other hand, the number of patients with nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) in the setting of metabolic syndrome has been increasing worldwide. Hepatocellular carcinoma (HCC) arises in the setting of chronic hepatic inflammation and liver cirrhosis associated with NAFLD/NASH. However, the detailed clinical features of NAFLD/NASH and NAFLD/NASH-derived HCC ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kim SK, Kim KI, Kim SR Tags: Yakugaku Zasshi Source Type: research

[Inhibition of Group IVA Phospholipase A2 as a Novel Therapeutic Strategy for Nonalcoholic Steatohepatitis].
Abstract Nonalcoholic steatohepatitis (NASH) is a lifestyle-related disease characterized by hepatic fibrosis with the accumulation of fat and inflammation and can progress to cirrhosis or hepatocellular carcinoma. However, effective pharmacotherapeutic strategies for hepatic fibrosis in NASH remain to be established. Among the initiators of inflammation, we have been investigating the possible involvement of group IVA phospholipase A2 (IVA-PLA2), which catalyzes the initial step in the generation of lipid mediators, including eicosanoids and lysophospholipids, in the progression of hepatic fibrosis. We have recen...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Akiba S, Kawashita E, Ishihara K Tags: Yakugaku Zasshi Source Type: research

[Role of Angiogenesis and Chronic Inflammation in Fat Hypertrophy in NASH Pathology].
Abstract Tissue expansion and chronic inflammation in adipose tissue (AT) are closely related to nonalcoholic steatohepatitis (NASH) pathology. Angiogenesis is initiated by the detachment of pericytes (PCs) from vessels in AT. This process is necessary for the development of AT in obesity. The detachment is caused by excessive platelet-derived growth factor B (PDGF-B) derived from M1-macrophages (Mφ) infiltrating obese AT. On the other hand, AT of tamoxifen-induced systemic PDGF receptor-β knockout mice showed decreased detachment of PCs from vessels in obesity, thereby attenuating hypertrophy of AT media...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Wada T, Tsuneki H, Sasaoka T Tags: Yakugaku Zasshi Source Type: research

[Involvement of the Free Fatty Acid Receptor GPR120/FFAR4 in the Development of Nonalcoholic Steatohepatitis].
In this study, we investigated the involvement of the G-protein-coupled receptor 120/free fatty acid receptor 4 (GPR120/FFAR4) in the pathogenesis of NASH. Mice fed a 0.1% methionine- and choline-deficient l-amino acid-defined, high-fat (CDAHF) diet showed a significant increase in plasma aspartate aminotransferase and alanine aminotransferase levels, fatty deposition, inflammatory cell infiltration, and slight fibrosis. Docosahexanoic acid (DHA, a GPR120/FFAR4 agonist) suppressed the inflammatory cytokines in hepatic tissues and prevented liver fibrosis. On the other hand, GPR120/FFAR4-deficient CDAHF-fed mice showed incr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Nakamoto K, Tokuyama S Tags: Yakugaku Zasshi Source Type: research

[A Retrospective Evaluation of the Impact of Multi-disciplinary Approach for Improving the Quality of Anticoagulation Therapy in Ambulatory Patients with Non-valvular Atrial Fibrillation Receiving Warfarin].
Abstract While percent time within therapeutic range (%TTR) of international normalized ratio of prothrombin time (PT-INR) represents the quality of anticoagulation therapy with warfarin, it is often maintained less than 50% in patients with non-valvular atrial fibrillation (NVAF). We aimed to study if implementation of a multi-disciplinary ambulatory anticoagulation service (MAAS) may improve %TTR. Collaborating with cardiologists at Kanto Rosai Hospital, we conducted a MAAS for NVAF patients receiving warfarin from April 2013 to December 2015. Patients who agreed to utilize the service in addition to their appoi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Ohgushi A, Nakayama N, Namiki A, Nagashima A, Ogawa R, Akazawa M, Echizen H Tags: Yakugaku Zasshi Source Type: research

[Improvement of the Non-aqueous Titration Method in the Japanese Pharmacopoeia for a Purpose of Advancement in Experimental Safety Using Alternative Solvents].
In this study, we attempted to improve the non-aqueous titration method using N,N-dimethylformamide (DMF) in the Japanese Pharmacopoeia seventeenth edition (JP XVII) for advancement in experimental safety. As an alternative solvent for DMF, we demonstrate titrations using dimethyl sulfoxide (DMSO), which has similar properties as and much higher safety than DMF. Five drugs (i.e., acetohexamide, glibenclamide, sulfamethoxazole, tranilast, and furosemide) listed in JP XVII use DMF as a solvent for titrations with sodium hydroxide standard solution. For these drugs, we examined whether DMF can be replaced with DMSO in quantit...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Okumura N, Kawanami K, Taniguchi M, Tomabechi A, Takeuchi T, Kitamura Y, Uno B Tags: Yakugaku Zasshi Source Type: research

[Educational Effect of Practical Training on Students' Robust Acquisition and Reconstruction of Expertise on Pharmaceutical Sciences They Had Learned before Practical Training].
Abstract Long-term practical training in the 6-year course of pharmaceutical education is a program for students after acquiring basic knowledge on pharmaceutical sciences and preclinical training. However, it remains unproved whether practical training affects students' robust acquisition and reconstruction of pharmaceutical expertise which they had learned before starting practical training. To address this issue, we administered survey questionnaires to 5th-year students (n=149) of Keio University in 2016 both before and after practical training. From the viewpoint of self-efficacy, psychological approach was a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 3, 2019 Category: Drugs & Pharmacology Authors: Kikuyama F, Suzuki S, Nakamura T Tags: Yakugaku Zasshi Source Type: research

[Development of High-resolution Methods for the Analysis of Drug Distribution in Biological Tissue Samples and Their Applications].
Abstract The abuse of drugs has become a serious social problem worldwide. Amphetamine-type stimulants such as methamphetamine are recreationally abused and can cause toxic effects in the body. Unfortunately, death from drug poisoning can occur due to careless intake. In postmortem examinations, the distribution of drugs in an entire organ gives valuable information for evaluating their toxicity. We developed methods to measure the distribution of drugs in organs using LC/MS and matrix-assisted laser desorption/ionization-imaging mass spectrometry (MALDI-IMS). The complementary use of the two methods provides more...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Kuwayama K Tags: Yakugaku Zasshi Source Type: research

[Academic Detailing Leading to Optimal Prescription: Supporting Prescription with Basic Pharmaceutical Sciences and Evidence].
PMID: 31366840 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Komoda M, Yamamoto M Tags: Yakugaku Zasshi Source Type: research

[Significance and Role of Academic Detailing for Optimal Medication].
Abstract "Academic detailing" is used to clearly explain scientific issues. In the field of clinical practice, "academic detailing" is a form of interactive educational outreach to physicians in order to provide unbiased, non-commercial, evidence-based information about medications and other therapeutic modalities, with the goal of improving patient care. It is necessary to provide proper information about prescription drugs for their appropriate use in clinical practice. However, this requires of physicians significant time and labor to comprehensively collect and summarize all necessary infor...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Yamamoto M, Hirosawa I, Doi H Tags: Yakugaku Zasshi Source Type: research

[Expectation for Academic Detailing by Pharmacists].
Abstract These days, the necessity of a multidisciplinary approach to cancer patients is well known. However, not all cancer patients are satisfied with their medical care. One reason for this is the difficulty integrating all the specialties required in order to provide individualized care that considers the needs of each patient. To achieve the best medical care, each specialist in any multidisciplinary teams needs to be a leader when it comes to his or her own specialty, to communicate with each other to share all the information available, and to apply evidence-based medicine considering each patient's physica...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Saito M Tags: Yakugaku Zasshi Source Type: research

[Practice Examples of Academic Detailing -Prescription Support Based on Basic Pharmaceutical Science and Evidence].
Abstract Better prescription assistance can be provided by applying basic pharmaceutical science concepts, and by considering evidence from clinical trials. For example, several drugs are currently used to treat ulcerative colitis (UC), a form of inflammatory bowel disease. In general, after a drug is administered, it is first absorbed into the upper part of the small intestine and then enters the bloodstream. However, 5-aminosalicylic acid (5-ASA), which is commonly used to treat UC, acts locally on the colonic mucosa; its absorption must be prevented in the upper gastrointestinal tract so that it can be delivere...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Sato M, Hirata J, Shibahara Y Tags: Yakugaku Zasshi Source Type: research

[What Is Medical Science Liaison?]
Abstract Currently, the role of medical representative (MR) is responsible for providing information to medical doctors from pharmaceutical/medical equipment companies. In recent years, however, the newer role of medical science liaison (MSL) has been established to construct evidence and provide advanced medical and scientific information to health care professionals. This position, independent from the sales division of a pharmaceutical or medical equipment company, has already been established in Europe and the U.S. The MSL helps to combat concerns of conflicts of interest (COI) concerning the sophistication of...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Sasaki M Tags: Yakugaku Zasshi Source Type: research

[Expectations of an Academic Detailer from a Pharmaceutical Industry Perspective].
Abstract In the pharmaceutical industry, a Medical Affairs ("MA") professional collects, organizes and transmits information about a health care product based on the judgment of science, medicine and ethical values, thereby optimizing the product's value, improving corporate value, and assuring quality medical care. The role of the MA is to construct a "medical strategy" through the process of collecting, analyzing and evaluating information. On the other hand, Academic Detailing is "a new approach to drug information that actively disseminates drug comparison information from a pharmacolo...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Taruno H Tags: Yakugaku Zasshi Source Type: research

[Academic Detailing from the Viewpoint of Chemical Structural Formulas].
Abstract In order to implement academic detailing, it is extremely important to understand the pharmacological activity of drugs based on their chemical structures. To construct a database for academic detailing, a viewpoint for clinically utilizing the fundamental pharmacological features of a drug is required. These fundamental pharmacological features include chemical characteristics such as chemical structures, physical characteristics such as pharmaceutical formulations for efficient drug delivery to target organs, and a pharmacological viewpoint, which is a mechanism by which a drug is determined to be effec...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Wada T Tags: Yakugaku Zasshi Source Type: research

[What Is Involved in the Training Program for a Japanese Academic Detailer?]
Abstract 'Academic Detailing' is an approach to providing doctors with information about medicines based on the latest non-commercial evidence-based data for proper prescription. Overseas, pharmacists have been active as academic detailers. Academic Detailing in Japan, as a new approach to disseminating comparative drug information based on basic pharmaceutical sciences and clinical evidence, will influence clinical decision making by doctors, and contribute to better patient-centered medical care. Pharmacists have been participating in ensuring the proper use of drugs by their patients by entering their homes or ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Komoda M, Negishi K, Mano Y, Ozeki R, Goto K Tags: Yakugaku Zasshi Source Type: research

[Development of Novel Genotyping Protocol and Its Application for Genotyping of Alcohol Metabolism-related Genes].
Abstract A new single nucleotide polymorphisms (SNP) genotyping method has been developed and validated using biological specimens directly as templates for TaqMan PCR without general DNA extraction and purification procedure from dried saliva samples attached on water-soluble papers. This new method can set up at ease and complete PCR analysis including data interpretation in under two hours with additional advantages of application for large-scale clinical research, diagnostics, and epidemiological studies at low cost. Specifically, SNP genotyping of alcohol metabolism-related genes ADH1B (rs1229984) and ALDH2 (...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Imai M, Kisoi M, Sakaguchi Y, Yamamura M, Kawai S, Murata S, Ichikawa A, Kinoshita K Tags: Yakugaku Zasshi Source Type: research

[Evaluation of Rheological Properties of Cohesive Ophthalmic Viscosurgical Devices Composed of Sodium Hyaluronate with High Molecular Weight-2019].
In conclusion, we demonstrated that each OVD has particular rheological properties within the range of the product specification defined by the intrinsic viscosity. The results might provide useful information for surgeons in their selection of OVDs based on their experience. PMID: 31366849 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - August 3, 2019 Category: Drugs & Pharmacology Authors: Watanabe I, Mirumachi H, Konno H, Suzuki K Tags: Yakugaku Zasshi Source Type: research

[Prion-like Propagation of Pathological α-Synuclein in Vivo].
[Prion-like Propagation of Pathological α-Synuclein in Vivo]. Yakugaku Zasshi. 2019;139(7):1007-1013 Authors: Masuda-Suzukake M, Hasegawa M Abstract α-Synuclein (αS) is the major component of the filamentous inclusions that constitute the defining characteristic of neurodegenerative synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. αS is deposited in a hyperphosphorylated and ubiquitinated form with a β-sheet-rich fibrillar structure in diseased brains. In 2008, some researchers reported that embryonic neurons transpl...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Masuda-Suzukake M, Hasegawa M Tags: Yakugaku Zasshi Source Type: research

[Prion-like Properties of Misfolded Cu/Zn-superoxide Dismutase in Amyotrophic Lateral Sclerosis: Update and Perspectives].
Abstract Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease that is characterized by the loss of motor neurons, which results in progressive muscle atrophy. The pathology spreads from the initial site of onset to contiguous anatomic regions. Mutations in the gene encoding Cu/Zn-superoxide dismutase (SOD1) have been identified in a dominantly inherited form of ALS (ALS-SOD1). A major hallmark of ALS-SOD1 is the abnormal accumulation of conformationally aberrant SOD1 protein (i.e., misfolded SOD1) within motor neurons. Emerging experimental evidence has suggested that misfolded proteins associ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Tokuda E, Marklund SL, Furukawa Y Tags: Yakugaku Zasshi Source Type: research

[Prion-like Propagation Model of Tau].
Abstract Abnormal proteins such as tau or α-synuclein that accumulate in brains with dementia have been shown to propagate like prion proteins. However, the expression patterns of tau in the mouse brain are different from those in humans, and the pathogenesis in the animal model of abnormal tau propagation remains incompletely understood. To overcome this problem, a novel mouse showing tau expression patterns similar to those of humans was developed using genome editing techniques. We inoculated the brain of this mouse with a sarkosyl-insoluble fraction containing abnormal tau derived from tauopathy patients...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Hosokawa M, Hasegawa M Tags: Yakugaku Zasshi Source Type: research

[Complementary and Alternative Medicine for Breast Cancer Patients: An Overview of Systematic Reviews].
In conclusion, since most SRs were at moderate or high quality levels, CAM could be helpful for treating specific symptoms related to breast cancer. PMID: 31257250 [PubMed - in process] (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Sasaki Y, Cheon C, Motoo Y, Jang S, Park S, Ko SG, Jang BH, Hwang DS Tags: Yakugaku Zasshi Source Type: research

[Improvements in Lifestyle from a Lifestyle Consecutive Self-Review at a Pharmacy].
This study tests such a service at a pharmacy. We prepared a lifestyle self-review test. From September 2015 to February 2016, pharmacists interviewed members of the community using the test, and pharmacists at 50 pharmacies in Aichi prefecture, Japan, set goals for lifestyle improvement. We analyzed 289 tests. The number of people who had a dietary goal concerning snacking was reduced from 19 people who snacked every day to 11. The number of people who had a goal to reduce their drinking was reduced from 7 people who drank every day to 4. The number of people who had an exercise goal was reduced from 17 people who did not...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - July 3, 2019 Category: Drugs & Pharmacology Authors: Suzuki R, Suzuki T, Kikuchi C Tags: Yakugaku Zasshi Source Type: research