Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Dissemination of Information from Basic Research on Aging: Species, Strain, Substrain and Sex Differences
Yakugaku Zasshi. 2024;144(4):389-395. doi: 10.1248/yakushi.23-00165-1.ABSTRACTVarious organisms with different lifespans such as yeast, nematodes, fruit fly, mice, and rats are used for basic research on mechanisms of aging and anti-aging. These organisms are often genetically engineered and used to elucidate the contribution of certain genes to aging. For example, genetic recombination techniques revealed that the lifespan of superoxide dismutase (SOD) transgenic flies extended up to approximately 30%. This result suggests that increasing antioxidant capacity extends lifespan possibly by reducing oxidative damage. However...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Ryoya Takahashi Keiko Odera Source Type: research

Aging-associated Cyst Formation and Fibrosis
Yakugaku Zasshi. 2024;144(4):397-402. doi: 10.1248/yakushi.23-00165-2.ABSTRACTCysts are abnormal fluid-filled sacs found in various human organs, including the liver. Liver cysts can be associated with known causes such as parasite infections and gene mutations, or simply aging. Among these causes, simple liver cysts are often found in elderly people. While they are generally benign, they may occasionally grow but rarely shrink with age, indicating their clear association with aging. However, the mechanism behind the formation of simple liver cysts has not been thoroughly investigated. Recently, we have generated transgeni...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yuichi Tsuchiya Takao Seki Hiroyasu Nakano Minoru Tanaka Ryoya Takahashi Source Type: research

Regulation of Aging Processes: A Perspective of Dietary Restriction Models
Yakugaku Zasshi. 2024;144(4):403-409. doi: 10.1248/yakushi.23-00165-3.ABSTRACTThe moderate restriction of dietary energy intake (dietary restriction: DR) extends the lifespan and health span of various laboratory animals, suggesting that it delays the aging process inherent in many animal species. Attenuated growth hormone and insulin-like growth factor-1 (IGF-1) signaling caused by mutations also increases the lifespan of mice, even those allowed to feed freely. In nematodes, the Daf16, mammalian Forkhead box O (FoxO) transcription factor, was shown to be required for lifespan extension in response to reduced IGF-1 signal...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Isao Shimokawa Source Type: research

Regulation of Aging and Lifespan by White Adipose Tissue
Yakugaku Zasshi. 2024;144(4):411-417. doi: 10.1248/yakushi.23-00165-4.ABSTRACTLong-term caloric restriction (CR) is an effective intervention that improves whole-body metabolism, suppresses age-related pathophysiology, and extends lifespan. Although the beneficial effects of caloric restriction mediated by growth hormone/insulin-like growth factor-1 (GH/IGF-1) have been extensively studied, the mechanisms independent of GH/IGF-1 remain largely unknown. In this review, we focus on these GH/IGF-1-independent mechanisms, with a particular emphasis on the role of sterol regulatory element-binding protein 1c (SREBP-1c). CR incr...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Tomoyoshi Fukuoh Yuka Nozaki Yuhei Mizunoe Yoshikazu Higami Source Type: research

Is Biological Aging a Treatable Disease? A Consideration Based on Proposed Mechanisms of Aging
Yakugaku Zasshi. 2024;144(4):419-429. doi: 10.1248/yakushi.23-00165-5.ABSTRACTIn view of the current claim by many researchers that biological aging is a treatable disease, the possibility is discussed whether the claim is realistic, based on several proposed mechanisms of aging. The definition of biological aging is stated referring to physiological aging and pathological aging, since biological aging must be defined for the discussion of whether it can be cured. Aging in animal model is compared with that in humans in terms of common age-associated phenotypes. Major proposed mechanisms of aging are next examined includin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Sataro Goto Source Type: research

Evaluation of the Simple Suspension Method for Oral Anticancer Drugs
Yakugaku Zasshi. 2024;144(4):441-445. doi: 10.1248/yakushi.23-00194.ABSTRACTThe simple suspension method (SSM) involves administering tablets or capsules using a tube after disintegration and suspension in hot water without crushing or opening the capsule. Particularly, for anticancer drugs, it is an excellent method of administration that reduces the risk of exposure during dispensing. In contrast, information on SSM for individual drugs is insufficient. Anticancer drugs present a therapeutic challenge because their information is limited. We investigated whether SSM is possible with 36 anticancer drugs. Furthermore, we e...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Tomoya Abe Sanae Kusakabe Miho Naoi Takayuki Suzuki Atsunobu Sagara Makoto Hiraide Motohiko Sano Toshiaki Nakayama Source Type: research

Examination of Analytical Method for Tris(2,3-dibromopropyl)phosphate and Bis(2,3-dibromopropyl)phosphate to Revise the Official Methods Based on "Act on the Control of Household Products Containing Harmful Substances"
In this study, the validity of the developed test method is evaluated at six laboratories using two types of textile samples spiked with TDBPP and BDBPP at three concentrations (4, 8, and 20 µg/g). TDBPP and BDBPP are extracted under reflux using methanol containing hydrochloric acid. TDBPP is analyzed using GC-MS, and BDBPP is also analyzed using GC-MS after methylation with trimethylsilyl diazomethane. Although the accuracy (70-120%), repeatability (<10%), and reproducibility (<15%) of a few samples, mainly low concentration samples, are out of range, overall, the concentration level of detection limits of TDBPP a...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Tsuyoshi Kawakami Tomoko Ooshima Masayuki Ohyama Naeko Sugaya Iwaki Nishi Taichi Yoshitomi Hisayoshi Takai Takanari Wakayama Hiroyuki Ohno Maiko Tahara Yoshiaki Ikarashi Source Type: research

Mechanistic Analysis of Oxidative Stress-related Diseases Using Nitroxyl Radicals and Electron Spin Resonance
Yakugaku Zasshi. 2024;144(4):339-344. doi: 10.1248/yakushi.23-00141.ABSTRACTExcessive production of reactive oxygen species (ROS) causes oxidative stress and is involved in the development and progression of a wide variety of diseases. Therefore, techniques for measuring oxidative stress are indispensable for analysis of the mechanisms of various diseases. The method involving ESR and the durable nitroxyl radical (ESR/spin probe method) is useful for this purpose, because the ESR signal intensity of the spin probe changes on reacting with ROS and other unstable radicals. In this review, the author's research applying the E...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Shoko Okazaki Source Type: research

Implementation and Future of Quantitative NMR in the Pharmaceutical and Food Fields
Yakugaku Zasshi. 2024;144(4):345-346. doi: 10.1248/yakushi.23-00151-F.NO ABSTRACTPMID:38556305 | DOI:10.1248/yakushi.23-00151-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Nahoko Uchiyama Naoki Sugimoto Source Type: research

Route to the Adoption of Quantitative NMR in the Japanese Pharmacopoeia
This report outlines how and why qNMR has been adopted as an official method in the JP and introduces its progression from JP16 to JP18. The results of a survey of companies in the Japan Pharmaceutical Manufacturers' Association regarding how and when to use qNMR from development to manufacturing stages are introduced. The issues involved in the expansion of the use of qNMR in the field of chemical pharmaceuticals in 2017 are discussed and how these were resolved.PMID:38556306 | DOI:10.1248/yakushi.23-00151-1 (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yukihiro Goda Source Type: research

Standardization and Practical Application of Quantitative NMR (qNMR)
Yakugaku Zasshi. 2024;144(4):353-357. doi: 10.1248/yakushi.23-00151-2.ABSTRACTIn Japan, quantitative NMR (qNMR) has already been recognized as a standard method for determining the purity of quantitative samples not only in the Japanese Pharmacopoeia and the Japanese Standards and Specifications for Food Additives but also in the Japanese Industrial Standard (JIS K 0138: 2018). However, since there was no consensus on the establishment of a standard method, the international standardization of qNMR was initiated based on a proposal from Japan. After three years of discussion among experts, International Organization for St...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Naoki Sugimoto Source Type: research

Quantitative < sup > 31 < /sup > P-NMR for Purity Determination of Organophosphorus Compounds (Pharmaceuticals)
Yakugaku Zasshi. 2024;144(4):359-365. doi: 10.1248/yakushi.23-00151-3.ABSTRACTQuantitative NMR (qNMR), particularly 1H-qNMR, is useful for determining the absolute purity of organic molecules. However, identifying the target signal(s) for quantification is difficult, because of the overlap and complexity of organic molecules. Therefore, we focused on the 31P nucleus, owing to the simplicity of its signals, and investigated the 31P-qNMR absolute determination method by using organophosphorus drugs, water-soluble cyclophosphamide hydrate (CP), and water-insoluble sofosbuvir (SOF). The optimized and reproducible 31P-qNMR cond...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Nahoko Uchiyama Source Type: research

High Purity Solvents for qNMR Measurement
In this study, we investigated the influence of solvent quality on qNMR accuracy focusing on organic impurities, water content, and deuteration ratio. If signals from organic impurities and signals from the analyte overlap, the duplication of signal integration will directly affect the qNMR analytical result. To examine overlapping, we performed blank solvent tests. Additionally, a high water content and low deuteration ratio affect the detection sensitivity, thus reducing the signal-to-noise (S/N) ratio of the target. Thus, these factors must be considered to obtain accurate qNMR results.PMID:38556309 | DOI:10.1248/yakush...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Yasuhiro Muto Toru Miura Yoshiaki Iwamoto Source Type: research

Application of qNMR in Standard Materials Used for the Crude Drugs
Yakugaku Zasshi. 2024;144(4):373-380. doi: 10.1248/yakushi.23-00151-5.ABSTRACTCrude drugs and Kampo formulations derived from natural materials such as plants, animals, and minerals are multicomponent medicines that contain numerous chemical constituents. Quantitative determination of characteristic constituents for quality control is crucial for the standardization and quality assurance of natural medicines. Quantitative assays to determine marker compound contents are commonly performed using HPLC systems. In order to achieve accurate quantitative determination, it is essential to use standard materials with well-defined...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Azusa Suzuki Source Type: research

The Applications of qNMR in Drug Quality Control
Yakugaku Zasshi. 2024;144(4):381-385. doi: 10.1248/yakushi.23-00151-6.ABSTRACTNMR is well known as one of the most important methods for elucidating the structure of organic compounds. Furthermore, it has recently been recognized as a powerful tool for quantitative analysis. The quantitative NMR (qNMR) has become an official analytical method described in detail in the Japanese Pharmacopoeia. And today, it is widely applied in drug development. The qNMR method offers many new advantages over traditional and conventional quantitative analysis methods. For example, this method requires only a few milligrams of the analyte an...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 31, 2024 Category: Drugs & Pharmacology Authors: Eri Ena Yumi Asai Takashi Hasebe Hiroshi Oe Shuichi Hirose Yoshimasa Takahashi Source Type: research